DT-Web

DB00527 - Dibucaine


Identification
Name Dibucaine
Accession Number DB00527 (APRD00915)
Type small molecule
Description A local anesthetic of the amide type now generally used for surface anesthesia. It is one of the most potent and toxic of the long-acting local anesthetics and its parenteral use is restricted to spinal anesthesia. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1006)
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 343.4632
Groups approved
Monoisotopic Weight 343.225977187
Pharmacology
Indication For production of local or regional anesthesia by infiltration techniques such as percutaneous injection and intravenous regional anesthesia by peripheral nerve block techniques such as brachial plexus and intercostal and by central neural techniques such as lumbar and caudal epidural blocks.
Mechanism of action Local anesthetics block both the initiation and conduction of nerve impulses by decreasing the neuronal membrane's permeability to sodium ions through sodium channel inhibition. This reversibly stabilizes the membrane and inhibits depolarization, resulting in the failure of a propagated action potential and subsequent conduction blockade.
Absorption In general, ionized forms (salts) of local anesthetics are not readily absorbed through intact skin. However, both nonionized (bases) and ionized forms of local anesthetics are readily absorbed through traumatized or abraded skin into the systemic circulation.
Protein binding Not Available
Biotransformation Primarily hepatic.
Route of elimination Not Available
Toxicity Subcutaneous LD50 in rat is 27 mg/kg. Symptoms of overdose include convulsions, hypoxia, acidosis, bradycardia, arrhythmias and cardiac arrest.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Sodium channel protein type 10 subunit alpha
Name Sodium channel protein type 10 subunit alpha
Gene Name SCN10A
Pharmacological action yes
Actions inhibitor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Louro SR, Anteneodo C, Wajnberg E: Carboxyl groups at the membrane interface as molecular targets for local anesthetics. Biophys Chem. 1998 Aug 4;74(1):35-43. - Pubmed
  • Ryan SE, Demers CN, Chew JP, Baenziger JE: Structural effects of neutral and anionic lipids on the nicotinic acetylcholine receptor. An infrared difference spectroscopy study. J Biol Chem. 1996 Oct 4;271(40):24590-7. - Pubmed
DTHybrid score 0.6744
Sodium channel protein type 5 subunit alpha
Name Sodium channel protein type 5 subunit alpha
Gene Name SCN5A
Pharmacological action yes
Actions inhibitor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Oka M, Itoh Y, Fujita T: Halothane attenuates the cerebroprotective action of several Na+ and Ca2+ channel blockers via reversal of their ion channel blockade. Eur J Pharmacol. 2002 Oct 4;452(2):175-81. - Pubmed
  • Louro SR, Anteneodo C, Wajnberg E: Carboxyl groups at the membrane interface as molecular targets for local anesthetics. Biophys Chem. 1998 Aug 4;74(1):35-43. - Pubmed
  • Ryan SE, Demers CN, Chew JP, Baenziger JE: Structural effects of neutral and anionic lipids on the nicotinic acetylcholine receptor. An infrared difference spectroscopy study. J Biol Chem. 1996 Oct 4;271(40):24590-7. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 0.5343
Calmodulin
Name Calmodulin
Gene Name CALM1
Pharmacological action unknown
Actions inhibitor
References
  • Muto Y, Kudo S, Nozawa Y: Effects of local anesthetics on calmodulin-dependent guanylate cyclase in the plasma membrane of Tetrahymena pyriformis. Biochem Pharmacol. 1983 Dec 1;32(23):3559-63. - Pubmed
  • Volpi M, Sha'afi RI, Epstein PM, Andrenyak DM, Feinstein MB: Local anesthetics, mepacrine, and propranolol are antagonists of calmodulin. Proc Natl Acad Sci U S A. 1981 Feb;78(2):795-9. - Pubmed
  • Liu SH, Fu WM, Lin-Shiau SY: Studies on the inhibition by chlorpromazine of myotonia induced by ion channel modulators in mouse skeletal muscle. Eur J Pharmacol. 1993 Jan 26;231(1):23-30. - Pubmed
  • Sambandam T, Gunasekaran M: Purification and properties of calmodulin from Phymatotrichum omnivorum. Microbios. 1993;73(294):61-74. - Pubmed
DTHybrid score 0.4106

Enzymes


Cholinesterase
Name Cholinesterase
Gene Name BCHE
Actions inhibitor
References
  • Elamin B: Dibucaine inhibition of serum cholinesterase. J Biochem Mol Biol. 2003 Mar 31;36(2):149-53. - Pubmed
DTHybrid score 0.6381

Predictions


Id Partner name Gene Name Score
4119 Cytochrome P450 2D6 CYP2D6 0.1145
474 Acetylcholinesterase ACHE 0.0937
4512 Cytochrome P450 3A4 CYP3A4 0.0911
4200 Cytochrome P450 1A2 CYP1A2 0.0886
1588 Multidrug resistance protein 1 ABCB1 0.067
6030 Cytochrome P450 2B6 CYP2B6 0.0617
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0582
6016 Cytochrome P450 2C19 CYP2C19 0.0489
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0464
4757 Cytochrome P450 2C9 CYP2C9 0.0444
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0436
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0432
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0423
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.04
1181 Alpha-1-acid glycoprotein 1 ORM1 0.039
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0374
4924 Cytochrome P450 2C8 CYP2C8 0.0356
1507 Cytochrome c CYCS 0.0356
722 Troponin I, cardiac muscle TNNI3 0.0347
713 Sodium-dependent dopamine transporter SLC6A3 0.034
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0333
341 5-hydroxytryptamine 3 receptor HTR3A 0.0302
587 Serum albumin ALB 0.0284
831 D(2) dopamine receptor DRD2 0.0283
766 Beta-2 adrenergic receptor ADRB2 0.0273
4118 Cytochrome P450 3A5 CYP3A5 0.027
6013 Cytochrome P450 2E1 CYP2E1 0.026
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0255
6144 Solute carrier family 22 member 2 SLC22A2 0.0243
4604 Liver carboxylesterase 1 CES1 0.0231
6107 Cytochrome P450 3A7 CYP3A7 0.0227
2433 Capsid protein P40 UL80 0.0213
3569 Capsid protein P40 BVRF2 0.0213
556 Alpha-1A adrenergic receptor ADRA1A 0.0203
2049 Gastrin/cholecystokinin type B receptor CCKBR 0.0191
6145 Solute carrier family 22 member 1 SLC22A1 0.019
3076 Antigen 85-C fbpC 0.0187
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0173
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0173
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0171
1089 Cartilage oligomeric matrix protein COMP 0.0168
1108 Calpastatin CAST 0.0168
6106 Cytochrome P450 2C18 CYP2C18 0.0167
6048 Troponin C, skeletal muscle TNNC2 0.0157
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0156
172 Potassium channel subfamily K member 1 KCNK1 0.0148
2796 Parathion hydrolase opd 0.0147
6539 Parathion hydrolase opd 0.0147
2392 Biphenyl-2,3-diol 1,2-dioxygenase bphC 0.0146
3032 Biphenyl-2,3-diol 1,2-dioxygenase bphC 0.0146
6024 Cytochrome P450 1A1 CYP1A1 0.0143
118 Organic cation/carnitine transporter 2 SLC22A5 0.0142
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0142
3454 Esterase estA 0.0141
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.014
23 D(1A) dopamine receptor DRD1 0.0135
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0134
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0132
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0132
6147 Solute carrier family 22 member 3 SLC22A3 0.013
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0129
2929 (S)-2-haloacid dehalogenase dhlB 0.0124
2995 (S)-2-haloacid dehalogenase Not Available 0.0124
2314 Triosephosphate isomerase TPI 0.0123
3417 Triosephosphate isomerase tpiA 0.0123
3443 Triosephosphate isomerase tpiA 0.0123
6346 Triosephosphate isomerase TPI1 0.0123
492 Histamine H1 receptor HRH1 0.0123
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0118
2795 Methionine aminopeptidase 2 METAP2 0.0117
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0108
638 D(3) dopamine receptor DRD3 0.0106
290 Prostaglandin G/H synthase 2 PTGS2 0.0105
5682 Ribonuclease pancreatic RNASE1 0.0104
5718 Cytochrome P450 2A6 CYP2A6 0.0104
244 Angiotensin-converting enzyme ACE 0.0101
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0101
833 Organic cation/carnitine transporter 1 SLC22A4 0.0099
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0098
4674 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase cumD 0.0097
33 Cystine/glutamate transporter SLC7A11 0.0097
2132 Protein S100-B S100B 0.0096
6859 Protein S100-A4 S100A4 0.0094
3947 Xanthine dehydrogenase/oxidase XDH 0.0093
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0092
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0091
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0087
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0086
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0086
844 Epidermal growth factor receptor EGFR 0.0085
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0085
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0085
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0084
318 Alpha-2A adrenergic receptor ADRA2A 0.0084
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0083
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0083
6220 Aryl hydrocarbon receptor AHR 0.0082
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0082
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0082
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.008
124 Histamine H2 receptor HRH2 0.008
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0079
275 Arachidonate 5-lipoxygenase ALOX5 0.0079
3811 Cytochrome P450 19A1 CYP19A1 0.0079
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0079
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0076
737 Mineralocorticoid receptor NR3C2 0.0075
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0072
824 Sodium-dependent serotonin transporter SLC6A4 0.0071
921 Glutamate receptor 2 GRIA2 0.007
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.007
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0069
20 Prostaglandin G/H synthase 1 PTGS1 0.0068
85 Growth hormone receptor GHR 0.0065
1262 Corticotropin-lipotropin POMC 0.0064
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0058
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0058
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0057
705 Glutamate receptor 1 GRIA1 0.0056
3830 Calreticulin CALR 0.0053
537 ATP synthase delta chain, mitochondrial ATP5D 0.0053
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0051
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0051
6035 Nuclear receptor ROR-beta RORB 0.005
6034 Hydroxyindole O-methyltransferase ASMT 0.005
482 Glycine receptor subunit alpha-1 GLRA1 0.005
6036 Eosinophil peroxidase EPX 0.005
131 Synaptic vesicular amine transporter SLC18A2 0.005
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0049
1656 CYP2B protein CYP2B 0.0047
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0047
378 Alpha-2C adrenergic receptor ADRA2C 0.0046
4784 Beta-mannosidase manB 0.0046
6695 Beta-mannosidase BT_0458 0.0046
6131 Carbonic anhydrase 14 CA14 0.0045
629 Alpha-2B adrenergic receptor ADRA2B 0.0045
765 Indoleamine 2,3-dioxygenase IDO1 0.0044
614 Progesterone receptor PGR 0.0043
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0043
232 Corticosteroid-binding globulin SERPINA6 0.0043
362 Melatonin receptor type 1B MTNR1B 0.0042
571 Melatonin receptor type 1A MTNR1A 0.0042
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0042
3480 Mannan endo-1,4-beta-mannosidase manA 0.0041
468 Cytochrome P450 4A11 CYP4A11 0.0041
467 Delta-type opioid receptor OPRD1 0.0041
696 Kappa-type opioid receptor OPRK1 0.0041
2998 Sialic acid-binding Ig-like lectin 7 SIGLEC7 0.004
146 Androgen receptor AR 0.0039
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0039
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0039
847 Mu-type opioid receptor OPRM1 0.0039
502 5-hydroxytryptamine 2A receptor HTR2A 0.0039
1757 Myeloperoxidase MPO 0.0037
871 Glucocorticoid receptor NR3C1 0.0036
776 Bile salt export pump ABCB11 0.0036
4787 Envelope glycoprotein gp160 env 0.0036
4820 Envelope glycoprotein gp160 env 0.0036
5727 Envelope glycoprotein gp160 env 0.0036
144 Hemoglobin subunit alpha HBA1 0.0036
2297 Genome polyprotein Not Available 0.0034
2322 Genome polyprotein Not Available 0.0034
2694 Genome polyprotein Not Available 0.0034
2719 Genome polyprotein Not Available 0.0034
2860 Genome polyprotein Not Available 0.0034
2928 Genome polyprotein Not Available 0.0034
3160 Genome polyprotein Not Available 0.0034
3260 Genome polyprotein Not Available 0.0034
4783 Genome polyprotein Not Available 0.0034
5726 Genome polyprotein Not Available 0.0034
5779 Genome polyprotein Not Available 0.0034
5867 Genome polyprotein Not Available 0.0034
6253 Genome polyprotein Not Available 0.0034
6301 Genome polyprotein Not Available 0.0034
6380 Genome polyprotein Not Available 0.0034
6381 Genome polyprotein Not Available 0.0034
6437 Genome polyprotein Not Available 0.0034
6520 Genome polyprotein Not Available 0.0034
6521 Genome polyprotein Not Available 0.0034
6652 Genome polyprotein Not Available 0.0034
6734 Genome polyprotein Not Available 0.0034
6735 Genome polyprotein Not Available 0.0034
6736 Genome polyprotein Not Available 0.0034
6737 Genome polyprotein Not Available 0.0034
6738 Genome polyprotein Not Available 0.0034
6739 Genome polyprotein Not Available 0.0034
6744 Genome polyprotein Not Available 0.0034
6748 Genome polyprotein Not Available 0.0034
6894 Genome polyprotein Not Available 0.0034
6898 Genome polyprotein Not Available 0.0034
6142 Solute carrier family 22 member 8 SLC22A8 0.0034
1517 Beta-3 adrenergic receptor ADRB3 0.0033
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0033
3426 Glutamine synthetase glnA 0.0033
3987 Glutamine synthetase GLUL 0.0033
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0032
1178 Adenosine A2a receptor ADORA2A 0.0031
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0031
436 5-hydroxytryptamine 2B receptor HTR2B 0.0031
3437 Eosinophil lysophospholipase CLC 0.003
632 Alpha-1B adrenergic receptor ADRA1B 0.0029
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0029
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0029
751 Potassium channel subfamily K member 6 KCNK6 0.0028
1898 Cytochrome P450 1B1 CYP1B1 0.0024
2207 Rhodopsin RHO 0.0024
6134 Sodium channel subunit beta-3 SCN3B 0.0024
6132 Sodium channel subunit beta-1 SCN1B 0.0024
6135 Sodium channel subunit beta-4 SCN4B 0.0024
6127 Carbonic anhydrase-related protein CA8 0.0024
6133 Sodium channel subunit beta-2 SCN2B 0.0024
6128 Carbonic anhydrase-related protein 10 CA10 0.0024
6129 Carbonic anhydrase-related protein 11 CA11 0.0024
136 Estrogen receptor ESR1 0.0023
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0023
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0023
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0023
394 Calcineurin subunit B isoform 1 PPP3R1 0.0022
6742 Recoverin RCVRN 0.0022
6752 Guanylyl cyclase-activating protein 1 GUCA1A 0.0022
2528 Fatty acid metabolism regulator protein fadR 0.0022
6740 Fatty acid metabolism regulator protein fadR 0.0022
6753 Apolipoprotein M APOM 0.0022
6747 Chalcone/stilbene synthase family protein MT1417 0.0022
6741 Peroxisomal 3,2-trans-enoyl-CoA isomerase PECI 0.0022
6743 Non-fluorescent flavoprotein luxF 0.0022
6751 Gag polyprotein gag 0.0022
6746 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform PPP3CA 0.0022
6522 Hepatocyte nuclear factor 4-alpha HNF4A 0.0022
6749 Polyprotein Not Available 0.0022
4785 Ig gamma-1 chain C region IGHG1 0.0022
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0022
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0021
6130 Carbonic anhydrase 13 CA13 0.002
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.002
789 Alpha-1D adrenergic receptor ADRA1D 0.002
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.002
102 DNA topoisomerase I, mitochondrial TOP1MT 0.002
5961 Insulin INS 0.002
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0019
6755 Poliovirus receptor PVR 0.0019
6527 Lymphocyte antigen 96 LY96 0.0019
862 Multidrug resistance-associated protein 1 ABCC1 0.0019
6122 Carbonic anhydrase 3 CA3 0.0018
6750 ADP-ribosylation factor 6 ARF6 0.0018
6524 Protein tonB tonB 0.0018
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0018
4373 Medium-chain-fatty-acid--CoA ligase Not Available 0.0018
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0017
3929 Phosphoethanolamine/phosphocholine phosphatase PHOSPHO1 0.0017
549 Choline-phosphate cytidylyltransferase B PCYT1B 0.0017
264 Choline/ethanolamine kinase [Includes: Choline kinase beta CHKB 0.0017
3927 Choline transporter-like protein 3 SLC44A3 0.0017
861 Choline kinase alpha CHKA 0.0017
3933 Choline/ethanolaminephosphotransferase CEPT1 0.0017
769 High-affinity choline transporter 1 SLC5A7 0.0017
700 Choline dehydrogenase, mitochondrial CHDH 0.0017
1686 Choline transporter-like protein 1 SLC44A1 0.0017
3926 Choline transporter-like protein 2 SLC44A2 0.0017
3925 Choline transporter-like protein 4 SLC44A4 0.0017
576 Choline O-acetyltransferase CHAT 0.0017
3922 Phospholipase D2 PLD2 0.0017
3924 Phospholipase D1 PLD1 0.0017
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0017
1353 DNA topoisomerase 1 TOP1 0.0017
3552 DNA topoisomerase 1 topA 0.0017
4210 Toll-like receptor 4 TLR4 0.0017
2616 Ganglioside GM2 activator GM2A 0.0017
3007 Carbonic anhydrase 12 CA12 0.0017
4205 Carbonic anhydrase 9 CA9 0.0017
2435 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase lpxC 0.0016
6613 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase lpxC 0.0016
904 Glutathione S-transferase P GSTP1 0.0016
6126 Carbonic anhydrase 7 CA7 0.0016
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0015
6316 ADP-ribosylation factor 1 ARF1 0.0015
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0014
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0014
6085 Fatty acid-binding protein, intestinal FABP2 0.0014
864 Gag-Pol polyprotein gag-pol 0.0014
2237 Gag-Pol polyprotein gag-pol 0.0014
2326 Gag-Pol polyprotein gag-pol 0.0014
2451 Gag-Pol polyprotein gag-pol 0.0014
2901 Gag-Pol polyprotein gag-pol 0.0014
3165 Gag-Pol polyprotein gag-pol 0.0014
3722 Gag-Pol polyprotein gag-pol 0.0014
6306 Gag-Pol polyprotein gag-pol 0.0014
6624 Gag-Pol polyprotein gag-pol 0.0014
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0014
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0014
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0014
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0013
6020 Aldehyde oxidase AOX1 0.0013
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0013
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0013
6163 Copper-transporting ATPase 2 ATP7B 0.0013
6165 Copper-transporting ATPase 1 ATP7A 0.0013
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0013
592 Carbonic anhydrase 4 CA4 0.0013
768 FK506-binding protein 1A FKBP1A 0.0012
4498 Ornithine cyclodeaminase PP3533 0.0012
6146 High affinity copper uptake protein 1 SLC31A1 0.0012
2427 Ferrichrome-iron receptor fhuA 0.0012
6228 Nuclear receptor coactivator 1 NCOA1 0.0012
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0012
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0012
295 Carbonic anhydrase 1 CA1 0.0012
5449 Hypothetical gliding protein mglB 0.0012
5443 UPF0189 protein ymdB ymdB 0.0012
5440 UPF0067 protein yebR yebR 0.0012
4705 Manganese catalase Not Available 0.0012
5439 33 kDa chaperonin hslO 0.0012
5446 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase HI_1679 0.0012
2720 Copper-containing nitrite reductase nirK 0.0012
5448 Ribonuclease Z rnz 0.0012
3781 Thiol:disulfide interchange protein dsbC precursor dsbC 0.0012
5447 Lethal(3)malignant brain tumor-like protein L3MBTL1 0.0012
5454 Internalin-A inlA 0.0012
332 Beta-lactamase blaZ 0.0012
2478 Beta-lactamase ampC 0.0012
2613 Beta-lactamase ampC 0.0012
2635 Beta-lactamase ampC 0.0012
2700 Beta-lactamase penP 0.0012
5445 Beta-lactamase blaB 0.0012
6019 Beta-lactamase SHV-7 0.0012
6701 Beta-lactamase cphA 0.0012
908 Glutathione S-transferase theta-1 GSTT1 0.0012
6264 cAMP-dependent protein kinase inhibitor alpha PKIA 0.0011
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0011
320 5-hydroxytryptamine 1A receptor HTR1A 0.0011
3941 Amine oxidase [flavin-containing] A MAOA 0.0011
3939 Amine oxidase [flavin-containing] B MAOB 0.0011
896 Glutathione S-transferase Mu 1 GSTM1 0.0011
6148 Multidrug resistance-associated protein 7 ABCC10 0.0011
3736 Glyceraldehyde-3-phosphate dehydrogenase A gapA 0.0011
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0011
5450 Prolyl endopeptidase Pep pep 0.0011
3356 Diaminopimelate decarboxylase lysA 0.001
6137 Multidrug resistance-associated protein 6 ABCC6 0.001
597 Dihydropteridine reductase QDPR 0.001
4771 Dissimilatory copper-containing nitrite reductase nir 0.001
3274 Hydroxylamine reductase hcp 0.001
4804 Hydroxylamine reductase hcp 0.001
2714 Chorismate mutase aroH 0.001
4611 Chorismate mutase aroG 0.001
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.001
3462 Tyrosine-protein kinase transforming protein Abl ABL 0.001
6136 Multidrug resistance-associated protein 5 ABCC5 0.001
3399 Limonene-1,2-epoxide hydrolase limA 0.001
3697 Bifunctional protein glmU [Includes: UDP-N-acetylglucosamine pyrophosphorylase glmU 0.001
4608 Putative cytochrome P450 SCO1207 0.0009
4963 Putative cytochrome P450 SCO2884 0.0009
6254 Putative cytochrome P450 SCO6998 0.0009
5180 L(+)-mandelate dehydrogenase mdlB 0.0009
577 Argininosuccinate lyase ASL 0.0009
357 Carbonic anhydrase 2 CA2 0.0009
3500 Putative family 31 glucosidase yicI yicI 0.0009
4878 Glycoprotein hormones alpha chain CGA 0.0009
1052 Cytotoxic T-lymphocyte protein 4 CTLA4 0.0009
1072 Granzyme B GZMB 0.0009
4889 Ig epsilon chain C region IGHE 0.0009
4877 Beta-mannanase man 0.0009
4871 Endo-beta-N-acetylglucosaminidase F3 endOF3 0.0009
4189 Alpha-galactosidase A GLA 0.0009
4850 Beta-2-glycoprotein 1 APOH 0.0009
4880 Membrane cofactor protein CD46 0.0009
4856 CD209 antigen CD209 0.0009
1354 Beta-glucuronidase GUSB 0.0009
757 Fusion glycoprotein F0 F 0.0009
4875 Fusion glycoprotein F0 F 0.0009
4869 Major capsid protein A430L 0.0009
4852 Reticulon-4 receptor RTN4R 0.0009
4845 ADAM 33 ADAM33 0.0009
1563 Platelet glycoprotein Ib alpha chain GP1BA 0.0009
442 Envelope glycoprotein gp41 0.0009
4859 Envelope glycoprotein env 0.0009
4882 Dipeptidyl aminopeptidase-like protein 6 DPP6 0.0009
4721 Beta-1,4-mannanase manA 0.0009
3352 Structural polyprotein Not Available 0.0009
3628 Structural polyprotein Not Available 0.0009
4892 Structural polyprotein Not Available 0.0009
2164 Multidrug resistance-associated protein 4 ABCC4 0.0009
1615 Chymase CMA1 0.0009
2597 Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] glmS 0.0008
365 Dihydrofolate reductase DHFR 0.0008
2381 Dihydrofolate reductase DFR1 0.0008
2833 Dihydrofolate reductase Not Available 0.0008
2931 Dihydrofolate reductase folA 0.0008
3544 Dihydrofolate reductase folA 0.0008
3682 Dihydrofolate reductase folA 0.0008
6642 Dihydrofolate reductase folA 0.0008
6756 Dihydrofolate reductase dfrA 0.0008
287 Beta-1,4-galactosyltransferase 1 B4GALT1 0.0008
4861 Interleukin-6 receptor alpha chain IL6R 0.0008
793 T-cell surface antigen CD2 CD2 0.0008
119 Carcinoembryonic antigen-related cell adhesion molecule 1 CEACAM1 0.0008
4193 Atrial natriuretic peptide clearance receptor NPR3 0.0008
3837 Cytokine receptor common beta chain CSF2RB 0.0008
4890 Hemagglutinin HA 0.0007
6566 Hemagglutinin Not Available 0.0007
1379 Interleukin-12 subunit beta IL12B 0.0007
4857 Zinc-alpha-2-glycoprotein AZGP1 0.0007
6858 Inactive carboxylesterase 4 CES1P1 0.0007
1184 Interferon beta IFNB1 0.0007
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0007
6120 Cation-independent mannose-6-phosphate receptor IGF2R 0.0007
18 High affinity immunoglobulin epsilon receptor subunit alpha FCER1A 0.0006
554 Low-density lipoprotein receptor LDLR 0.0006
852 Heparin cofactor 2 SERPIND1 0.0006
1859 Prostatic acid phosphatase ACPP 0.0006
3444 Cyanovirin-N Not Available 0.0006
3140 Hemagglutinin-neuraminidase HN 0.0006
3609 Hemagglutinin-neuraminidase HN 0.0006
595 Fibrinogen alpha chain FGA 0.0006
3258 Mannosyl-oligosaccharide alpha-1,2-mannosidase MSDC 0.0006
4666 Fucose-binding lectin PA-IIL lecB 0.0005
2372 Bifunctional tail protein 9 0.0005
958 Insulin-like growth factor 1 receptor IGF1R 0.0005
2577 Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase MAN1B1 0.0005
3814 Complement C1r subcomponent C1R 0.0005
64 Neuraminidase NA 0.0005
641 Neuraminidase NA 0.0005
2676 Neuraminidase NA 0.0005
3026 Neuraminidase NA 0.0005
3519 Neuraminidase NA 0.0005
6007 Neuraminidase NA 0.0005
1243 Cathepsin D CTSD 0.0005
1439 Lactotransferrin LTF 0.0005
1782 Neutrophil gelatinase-associated lipocalin LCN2 0.0005
309 Antithrombin-III SERPINC1 0.0005
2430 Chondroitinase B cslB 0.0004
6307 Ig gamma-2 chain C region IGHG2 0.0004
2581 Chondroitinase AC cslA 0.0004
6847 Lactase-phlorizin hydrolase LCT 0.0004
6500 Phospholipase A2 PLA2G1B 0.0004
76 Nitric-oxide synthase, brain NOS1 0.0003
952 Dipeptidyl peptidase 4 DPP4 0.0003
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