DT-Web

DB00686 - Pentosan Polysulfate


Identification
Name Pentosan Polysulfate
Accession Number DB00686 (APRD01175)
Type small molecule
Description A sulfated pentosyl polysaccharide with heparin-like properties. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 602.497
Groups approved
Monoisotopic Weight 601.922340398
Pharmacology
Indication For the relief of bladder pain or discomfort associated with interstitial cystitis.
Mechanism of action Pentosan polysulfate is a polymer of xylose hydrogen sulfate and contains two sulfate groups per carbohydrate monomer. It binds Fibroblast growth factors (FGFs) as well as other heparin-binding growth factors. It has been shown to interact also with the heparin-binding site of FGFR-1. It inhibits the growth of SW13 adrenocortical cells transfected with FGF-4 and tumorigenicity of MCF-7 breast carcinoma cells transfected with FGF-1 or FGF-4.
Absorption Slow
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions Not Available
Food Interactions
  • Take on an empty stomach, 1 hour before or 2 hours after meals.

Targets


Heparin-binding growth factor 2
Name Heparin-binding growth factor 2
Gene Name FGF2
Pharmacological action yes
Actions antagonist
References
  • Zugmaier G, Favoni R, Jaeger R, Rosen N, Knabbe C: Polysulfated heparinoids selectively inactivate heparin-binding angiogenesis factors. Ann N Y Acad Sci. 1999;886:243-8. - Pubmed
  • Mucha S, Melen-Mucha G, Stepien T, Godlewski A, Stepien H: Effects of pentosan polysulfate sodium on the estrogen-induced pituitary prolactinoma in Fischer 344 rats. Oncol Rep. 2002 Nov-Dec;9(6):1385-9. - Pubmed
  • Pluda JM, Shay LE, Foli A, Tannenbaum S, Cohen PJ, Goldspiel BR, Adamo D, Cooper MR, Broder S, Yarchoan R: Administration of pentosan polysulfate to patients with human immunodeficiency virus-associated Kaposi's sarcoma. J Natl Cancer Inst. 1993 Oct 6;85(19):1585-92. - Pubmed
  • McLeskey SW, Zhang L, Kharbanda S, Kurebayashi J, Lippman ME, Dickson RB, Kern FG: Fibroblast growth factor overexpressing breast carcinoma cells as models of angiogenesis and metastasis. Breast Cancer Res Treat. 1996;39(1):103-17. - Pubmed
  • Jerebtsova M, Wong E, Przygodzki R, Tang P, Ray PE: A novel role of fibroblast growth factor-2 and pentosan polysulfate in the pathogenesis of intestinal bleeding in mice. Am J Physiol Heart Circ Physiol. 2007 Feb;292(2):H743-50. Epub 2006 Oct 27. - Pubmed
DTHybrid score 0.9821
Fibroblast growth factor 1
Name Fibroblast growth factor 1
Gene Name FGF1
Pharmacological action yes
Actions antagonist
References
  • Pascu C, Ljungh A, Wadstrom T: Staphylococci bind heparin-binding host growth factors. Curr Microbiol. 1996 Apr;32(4):201-7. - Pubmed
  • Zenjari C, Boilly-Marer Y, Desbiens X, Oudghir M, Hondermarck H, Boilly B: Experimental evidence for FGF-1 control of blastema cell proliferation during limb regeneration of the amphibian Pleurodeles waltl. Int J Dev Biol. 1996 Oct;40(5):965-71. - Pubmed
  • Jerebtsova M, Wong E, Przygodzki R, Tang P, Ray PE: A novel role of fibroblast growth factor-2 and pentosan polysulfate in the pathogenesis of intestinal bleeding in mice. Am J Physiol Heart Circ Physiol. 2007 Feb;292(2):H743-50. Epub 2006 Oct 27. - Pubmed
DTHybrid score 1.165
Fibroblast growth factor 4
Name Fibroblast growth factor 4
Gene Name FGF4
Pharmacological action unknown
Actions inhibitor
References
  • Zugmaier G, Lippman ME, Wellstein A: Inhibition by pentosan polysulfate (PPS) of heparin-binding growth factors released from tumor cells and blockage by PPS of tumor growth in animals. J Natl Cancer Inst. 1992 Nov 18;84(22):1716-24. - Pubmed
  • McLeskey SW, Zhang L, Kharbanda S, Kurebayashi J, Lippman ME, Dickson RB, Kern FG: Fibroblast growth factor overexpressing breast carcinoma cells as models of angiogenesis and metastasis. Breast Cancer Res Treat. 1996;39(1):103-17. - Pubmed
  • Wellstein A, Zugmaier G, Califano JA 3rd, Kern F, Paik S, Lippman ME: Tumor growth dependent on Kaposi's sarcoma-derived fibroblast growth factor inhibited by pentosan polysulfate. J Natl Cancer Inst. 1991 May 15;83(10):716-20. - Pubmed
DTHybrid score 0.8313

Predictions


Id Partner name Gene Name Score
2805 Heparan sulfate glucosamine 3-O-sulfotransferase 3A1 HS3ST3A1 0.2562
1943 Hepatocyte growth factor HGF 0.1644
2654 Complement control protein C3L 0.1508
138 Interleukin-3 IL3 0.0493
2226 Protein S100-A12 S100A12 0.0415
1048 Protein S100-A13 S100A13 0.0415
3812 Fibrinogen beta chain [Contains: Fibrinopeptide B] FGB 0.0407
3813 Fibrinogen gamma chain FGG 0.0407
595 Fibrinogen alpha chain FGA 0.0385
1278 Pro-epidermal growth factor EGF 0.0378
6231 Pepsin A PGA3 0.0319
4148 Serine/threonine-protein kinase mTOR MTOR 0.0243
768 FK506-binding protein 1A FKBP1A 0.0204
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0192
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0183
587 Serum albumin ALB 0.0143
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0138
1588 Multidrug resistance protein 1 ABCB1 0.0131
3856 Fibroblast growth factor receptor 3 FGFR3 0.0131
4512 Cytochrome P450 3A4 CYP3A4 0.0115
6107 Cytochrome P450 3A7 CYP3A7 0.0107
4118 Cytochrome P450 3A5 CYP3A5 0.0102
26 Vascular endothelial growth factor receptor 3 FLT4 0.0101
950 Alpha platelet-derived growth factor receptor PDGFRA 0.01
32 Vascular endothelial growth factor receptor 1 FLT1 0.01
228 Beta platelet-derived growth factor receptor PDGFRB 0.0088
504 Mast/stem cell growth factor receptor KIT 0.0087
407 Vascular endothelial growth factor receptor 2 KDR 0.0086
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0058
4545 Molybdopterin-converting factor subunit 2 moaE 0.0055
4037 Hypothetical protein GPX1 0.0055
4297 Hypothetical protein SP_1951 0.0055
4521 Hypothetical protein BC_2969 0.0055
4540 Hypothetical protein TM_1070 0.0055
4555 Hypothetical protein MT1739 0.0055
4569 Hypothetical protein mshD 0.0055
4578 Hypothetical protein PA3270 0.0055
4747 Hypothetical protein PA3967 0.0055
5177 Hypothetical protein TM_0096 0.0055
5194 Hypothetical protein PA1204 0.0055
5240 Hypothetical protein Rv2991 0.0055
5370 Hypothetical protein TM_1158 0.0055
5710 Hypothetical protein Tb927.5.1360 0.0055
4106 Guanylate kinase GUK1 0.0055
4516 Guanylate kinase gmk 0.0055
4527 Putative hydrolase ycdX ycdX 0.0055
4536 Transcriptional regulator, IclR family TM_0065 0.0055
4546 Aminotransferase, putative TM_1131 0.0055
2501 Protein ygbM ygbM 0.0055
4514 Citrate lyase beta subunit-like protein citE 0.0055
4781 Citrate lyase beta subunit-like protein DR_1240 0.0055
4548 Gyrase B gyrB 0.0055
4526 Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein TM_1223 0.0055
4524 Mannose-6-phosphate isomerase yvyI 0.0055
4535 Glutaconyl-CoA decarboxylase subunit alpha gcdA 0.0055
4522 Arginine N-succinyltransferase subunit alpha astA 0.0055
4547 Iron binding protein FbpA fbpA 0.0055
4538 Hypothetical protein VC1899 VC_1899 0.0055
4529 Oxalate decarboxylase oxdC oxdC 0.0055
658 Para-aminobenzoate synthase component 1 pabB 0.0055
4515 Peripheral plasma membrane protein CASK CASK 0.0055
4496 C-terminal-binding protein 1 CTBP1 0.005
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0049
3261 Signal recognition particle protein ffh 0.0048
4517 Probable butyrate kinase 2 buk2 0.0048
4533 Glyoxalase family protein BC_1747 0.0048
4528 Phenazine biosynthesis protein PhzD phzD1 0.0048
3759 Glutathione S-transferase gst 0.0048
4541 Glutathione S-transferase GST 0.0048
3237 Beta-lactamase OXA-2 bla 0.0048
56 Delta-aminolevulinic acid dehydratase ALAD 0.0048
2356 Delta-aminolevulinic acid dehydratase hemB 0.0048
3613 Delta-aminolevulinic acid dehydratase hemB 0.0048
3674 Delta-aminolevulinic acid dehydratase hemB 0.0048
4542 Glutaminase 1 glsA1 0.0048
4544 Glutaminase 1 glsA1 0.0048
2929 (S)-2-haloacid dehalogenase dhlB 0.0048
2995 (S)-2-haloacid dehalogenase Not Available 0.0048
4532 Gephyrin GPHN 0.0048
2230 Catalase CAT 0.0045
3249 Catalase katA 0.0045
3625 Catalase katA 0.0045
4539 Catalase katA 0.0045
4941 Catalase katB 0.0045
2775 Dihydroorotate dehydrogenase pyrD 0.0044
4531 Putative ketoacyl reductase actIII 0.0044
3583 6-phosphogluconolactonase pgl 0.0044
3467 Methylglyoxal synthase mgsA 0.0044
2525 3-phosphoshikimate 1-carboxyvinyltransferase aroA 0.0042
3201 3-phosphoshikimate 1-carboxyvinyltransferase aroA 0.0042
4924 Cytochrome P450 2C8 CYP2C8 0.004
2688 Peptide deformylase def 0.004
2708 Peptide deformylase def 0.004
3004 Peptide deformylase def 0.004
4337 Peptide deformylase def 0.004
4338 Peptide deformylase def 0.004
5368 Peptide deformylase def 0.004
5371 Peptide deformylase def 0.004
6375 Peptide deformylase def 0.004
6378 Peptide deformylase def 0.004
6379 Peptide deformylase def 0.004
6776 Peptide deformylase def 0.004
6900 Peptide deformylase def 0.004
4534 Cytohesin-2 CYTH2 0.004
4269 Hypoxanthine-guanine phosphoribosyltransferase, putative HGPRTase 0.0038
2548 Subtilisin Carlsberg apr 0.0038
4200 Cytochrome P450 1A2 CYP1A2 0.0038
4119 Cytochrome P450 2D6 CYP2D6 0.0036
810 Heme oxygenase 1 HMOX1 0.0033
3391 Heme oxygenase 1 pbsA1 0.0033
3027 Streptavidin Not Available 0.0032
500 Monocarboxylate transporter 4 SLC16A3 0.0031
76 Nitric-oxide synthase, brain NOS1 0.0028
5682 Ribonuclease pancreatic RNASE1 0.0028
357 Carbonic anhydrase 2 CA2 0.0021
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