DT-Web

DB03959 - N,O6-Disulfo-Glucosamine


Identification
Name N,O6-Disulfo-Glucosamine
Accession Number DB03959 (EXPT02898)
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 339.298
Groups experimental
Monoisotopic Weight 338.993001643
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Heparin-binding growth factor 2
Name Heparin-binding growth factor 2
Gene Name FGF2
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.0745
Fibroblast growth factor 1
Name Fibroblast growth factor 1
Gene Name FGF1
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.4932
Heparan sulfate glucosamine 3-O-sulfotransferase 3A1
Name Heparan sulfate glucosamine 3-O-sulfotransferase 3A1
Gene Name HS3ST3A1
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.2284
Hepatocyte growth factor
Name Hepatocyte growth factor
Gene Name HGF
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.0754
Complement control protein
Name Complement control protein
Gene Name C3L
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.0479
Annexin A5
Name Annexin A5
Gene Name ANXA5
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score Not Available

Predictions


Id Partner name Gene Name Score
361 Fibroblast growth factor 4 FGF4 0.1647
4165 P2Y purinoceptor 2 P2RY2 0.0786
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.057
430 Follicle-stimulating hormone receptor FSHR 0.0569
5455 Arylsulfatase A ARSA 0.0537
138 Interleukin-3 IL3 0.0493
814 Ryanodine receptor 1 RYR1 0.046
2981 Phospholipase A2, membrane associated PLA2G2A 0.0438
3317 Holo-[acyl-carrier-protein] synthase acpS 0.0427
4381 Holo-[acyl-carrier-protein] synthase acpS 0.0427
4380 Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 NDST1 0.0427
4382 Sulfotransferase family cytosolic 1B member 1 SULT1B1 0.0427
2226 Protein S100-A12 S100A12 0.0415
1048 Protein S100-A13 S100A13 0.0415
3812 Fibrinogen beta chain [Contains: Fibrinopeptide B] FGB 0.0407
3813 Fibrinogen gamma chain FGG 0.0407
595 Fibrinogen alpha chain FGA 0.0385
1278 Pro-epidermal growth factor EGF 0.0378
723 Cytosolic phospholipase A2 PLA2G4A 0.037
2390 Nonsecretory ribonuclease RNASE2 0.0343
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0324
6231 Pepsin A PGA3 0.0319
54 Prothrombin F2 0.0308
1353 DNA topoisomerase 1 TOP1 0.0305
3552 DNA topoisomerase 1 topA 0.0305
1050 Bile salt sulfotransferase SULT2A1 0.0278
5682 Ribonuclease pancreatic RNASE1 0.0278
1275 Estrogen sulfotransferase SULT1E1 0.0259
1192 Sulfotransferase 1A1 SULT1A1 0.0258
4148 Serine/threonine-protein kinase mTOR MTOR 0.0243
768 FK506-binding protein 1A FKBP1A 0.0204
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0192
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0183
587 Serum albumin ALB 0.0143
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0138
1588 Multidrug resistance protein 1 ABCB1 0.0131
3856 Fibroblast growth factor receptor 3 FGFR3 0.0131
4512 Cytochrome P450 3A4 CYP3A4 0.0115
4533 Glyoxalase family protein BC_1747 0.0112
6107 Cytochrome P450 3A7 CYP3A7 0.0107
3583 6-phosphogluconolactonase pgl 0.0103
4118 Cytochrome P450 3A5 CYP3A5 0.0102
26 Vascular endothelial growth factor receptor 3 FLT4 0.0101
950 Alpha platelet-derived growth factor receptor PDGFRA 0.01
32 Vascular endothelial growth factor receptor 1 FLT1 0.01
228 Beta platelet-derived growth factor receptor PDGFRB 0.0088
504 Mast/stem cell growth factor receptor KIT 0.0087
407 Vascular endothelial growth factor receptor 2 KDR 0.0086
5587 Iron(III)-binding periplasmic protein fbpA 0.0074
5598 Glycerol uptake operon antiterminator-related protein TM_1436 0.0073
5577 N5-carboxyaminoimidazole ribonucleotide mutase purE 0.0073
2300 Lysozyme E 0.0073
3633 Lysozyme R 0.0073
5597 Lysozyme 17 0.0073
5600 Pyruvate decarboxylase pdc 0.0073
5591 Complement component C8 gamma chain C8G 0.0073
3792 KHG/KDPG aldolase [Includes: 4-hydroxy-2-oxoglutarate aldolase eda 0.0073
5582 Regulator of transcription; stringent starvation protein A sspA 0.0073
2838 Ribose-5-phosphate isomerase A rpiA 0.0073
2952 Ribose-5-phosphate isomerase A rpiA 0.0073
5595 Ribose-5-phosphate isomerase A rpiA 0.0073
4238 50S ribosomal protein L4 rplD 0.0073
5578 50S ribosomal protein L4 rplD 0.0073
6173 50S ribosomal protein L4 rplD 0.0073
6219 50S ribosomal protein L4 rplD 0.0073
4695 UPF0124 protein yfiH yfiH 0.0073
5590 N utilization substance protein B homolog nusB 0.0073
5593 Transferase Not Available 0.0073
5588 Cell division protein FtsY TM_0570 0.0073
5592 Ribonucleoside-diphosphate reductase subunit beta nrdF 0.0073
5583 RNA 3'-terminal phosphate cyclase rtcA 0.0073
5586 Pleckstrin homology domain-containing family A member 1 PLEKHA1 0.0073
5581 Beta-fructosidase bfrA 0.0073
5060 Intron-associated endonuclease 1 ITEVIR 0.0073
4375 Glutamine synthetase 1 glnA1 0.0073
5575 Short tail fiber protein 12 0.0073
5580 Hexon protein PII 0.0073
5574 Invasin YPTB1668 0.0073
3085 Molybdopterin-guanine dinucleotide biosynthesis protein A mobA 0.0064
5006 RNASE4 protein RNASE4 0.0064
3087 Nicotinate-nucleotide adenylyltransferase nadD 0.0064
4469 Nicotinate-nucleotide adenylyltransferase nadD 0.0064
355 GMP synthase [glutamine-hydrolyzing] GMPS 0.0064
4353 GMP synthase [glutamine-hydrolyzing] guaA 0.0064
3132 Tryptophan synthase alpha chain trpA 0.0064
6568 Tryptophan synthase alpha chain trpA 0.0064
3729 Citrate synthase gltA 0.0064
4575 Citrate synthase cit 0.0064
4580 Citrate synthase gltA 0.0064
5599 3-carboxy-cis,cis-muconate cycloisomerase pcaB 0.0064
5328 Prostaglandin F synthase Tb11.02.2310 0.0064
4992 Cytochrome c peroxidase Not Available 0.0064
2555 Pol polyprotein pol 0.0064
3242 Pol polyprotein gag-pol 0.0064
3471 Pol polyprotein gag-pro-pol 0.0064
5256 Pol polyprotein pol 0.0064
6469 Pol polyprotein gag-pol 0.0064
6565 Pol polyprotein Not Available 0.0064
2149 Angiogenin ANG 0.0059
2603 Beta-lactamase II blm 0.0059
1467 Tumor necrosis factor ligand superfamily member 13B TNFSF13B 0.0059
2521 Cell division protein ftsZ ftsZ 0.0059
3301 Cell division protein ftsZ ftsZ 0.0059
4373 Medium-chain-fatty-acid--CoA ligase Not Available 0.0059
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0058
2869 1-deoxy-D-xylulose 5-phosphate reductoisomerase dxr 0.0056
2286 Isocitrate dehydrogenase [NADP] icd 0.0056
2302 Isocitrate dehydrogenase [NADP] icd 0.0056
2771 Isocitrate dehydrogenase [NADP] icd 0.0056
3486 Fumarate hydratase class II fumC 0.0056
4366 Riboflavin kinase/FMN adenylyltransferase TM_0857 0.0056
2942 Sialidase nanH 0.0056
3546 Sialidase nedA 0.0056
4545 Molybdopterin-converting factor subunit 2 moaE 0.0055
4037 Hypothetical protein GPX1 0.0055
4297 Hypothetical protein SP_1951 0.0055
4521 Hypothetical protein BC_2969 0.0055
4540 Hypothetical protein TM_1070 0.0055
4555 Hypothetical protein MT1739 0.0055
4569 Hypothetical protein mshD 0.0055
4578 Hypothetical protein PA3270 0.0055
4747 Hypothetical protein PA3967 0.0055
5177 Hypothetical protein TM_0096 0.0055
5194 Hypothetical protein PA1204 0.0055
5240 Hypothetical protein Rv2991 0.0055
5370 Hypothetical protein TM_1158 0.0055
5710 Hypothetical protein Tb927.5.1360 0.0055
4106 Guanylate kinase GUK1 0.0055
4516 Guanylate kinase gmk 0.0055
4527 Putative hydrolase ycdX ycdX 0.0055
4536 Transcriptional regulator, IclR family TM_0065 0.0055
4546 Aminotransferase, putative TM_1131 0.0055
2501 Protein ygbM ygbM 0.0055
4514 Citrate lyase beta subunit-like protein citE 0.0055
4781 Citrate lyase beta subunit-like protein DR_1240 0.0055
4548 Gyrase B gyrB 0.0055
4526 Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein TM_1223 0.0055
4524 Mannose-6-phosphate isomerase yvyI 0.0055
4535 Glutaconyl-CoA decarboxylase subunit alpha gcdA 0.0055
4522 Arginine N-succinyltransferase subunit alpha astA 0.0055
4547 Iron binding protein FbpA fbpA 0.0055
4538 Hypothetical protein VC1899 VC_1899 0.0055
4529 Oxalate decarboxylase oxdC oxdC 0.0055
658 Para-aminobenzoate synthase component 1 pabB 0.0055
4515 Peripheral plasma membrane protein CASK CASK 0.0055
857 Malate dehydrogenase, mitochondrial MDH2 0.0053
941 Betaine--homocysteine S-methyltransferase 1 BHMT 0.0052
2697 Uridine-cytidine kinase 2 UCK2 0.0051
2936 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0051
5184 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0051
332 Beta-lactamase blaZ 0.0051
2478 Beta-lactamase ampC 0.0051
2613 Beta-lactamase ampC 0.0051
2635 Beta-lactamase ampC 0.0051
2700 Beta-lactamase penP 0.0051
5445 Beta-lactamase blaB 0.0051
6019 Beta-lactamase SHV-7 0.0051
6701 Beta-lactamase cphA 0.0051
1123 Eosinophil cationic protein RNASE3 0.0051
2452 Tryptophanyl-tRNA synthetase trpS 0.005
4496 C-terminal-binding protein 1 CTBP1 0.005
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0049
5579 Carboxypeptidase B CPB1 0.0048
3261 Signal recognition particle protein ffh 0.0048
4517 Probable butyrate kinase 2 buk2 0.0048
4528 Phenazine biosynthesis protein PhzD phzD1 0.0048
3759 Glutathione S-transferase gst 0.0048
4541 Glutathione S-transferase GST 0.0048
3237 Beta-lactamase OXA-2 bla 0.0048
56 Delta-aminolevulinic acid dehydratase ALAD 0.0048
2356 Delta-aminolevulinic acid dehydratase hemB 0.0048
3613 Delta-aminolevulinic acid dehydratase hemB 0.0048
3674 Delta-aminolevulinic acid dehydratase hemB 0.0048
4542 Glutaminase 1 glsA1 0.0048
4544 Glutaminase 1 glsA1 0.0048
2929 (S)-2-haloacid dehalogenase dhlB 0.0048
2995 (S)-2-haloacid dehalogenase Not Available 0.0048
4532 Gephyrin GPHN 0.0048
3478 Glucose-1-phosphate thymidylyltransferase rmlA 0.0047
4277 Glucose-1-phosphate thymidylyltransferase rmlA 0.0047
3384 Macrophage migration inhibitory factor MIF 0.0047
411 Glycine N-methyltransferase GNMT 0.0046
2230 Catalase CAT 0.0045
3249 Catalase katA 0.0045
3625 Catalase katA 0.0045
4539 Catalase katA 0.0045
4941 Catalase katB 0.0045
2775 Dihydroorotate dehydrogenase pyrD 0.0044
4531 Putative ketoacyl reductase actIII 0.0044
3467 Methylglyoxal synthase mgsA 0.0044
128 Adenine phosphoribosyltransferase APRT 0.0042
2525 3-phosphoshikimate 1-carboxyvinyltransferase aroA 0.0042
3201 3-phosphoshikimate 1-carboxyvinyltransferase aroA 0.0042
4924 Cytochrome P450 2C8 CYP2C8 0.004
2688 Peptide deformylase def 0.004
2708 Peptide deformylase def 0.004
3004 Peptide deformylase def 0.004
4337 Peptide deformylase def 0.004
4338 Peptide deformylase def 0.004
5368 Peptide deformylase def 0.004
5371 Peptide deformylase def 0.004
6375 Peptide deformylase def 0.004
6378 Peptide deformylase def 0.004
6379 Peptide deformylase def 0.004
6776 Peptide deformylase def 0.004
6900 Peptide deformylase def 0.004
4534 Cytohesin-2 CYTH2 0.004
4269 Hypoxanthine-guanine phosphoribosyltransferase, putative HGPRTase 0.0038
2548 Subtilisin Carlsberg apr 0.0038
4200 Cytochrome P450 1A2 CYP1A2 0.0038
822 Aldose reductase AKR1B1 0.0036
4119 Cytochrome P450 2D6 CYP2D6 0.0036
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0036
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0034
810 Heme oxygenase 1 HMOX1 0.0033
3391 Heme oxygenase 1 pbsA1 0.0033
3027 Streptavidin Not Available 0.0032
500 Monocarboxylate transporter 4 SLC16A3 0.0031
76 Nitric-oxide synthase, brain NOS1 0.0028
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0027
357 Carbonic anhydrase 2 CA2 0.0021
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