DT-Web: DB00819

Identification

Name

Acetazolamide

Accession Number

DB00819 (APRD00119, EXPT00604)

Type

small molecule

Description

One of the carbonic anhydrase inhibitors that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual cycle. However, its usefulness is transient often because of rapid development of tolerance. Its antiepileptic effect may be due to its inhibitory effect on brain carbonic anhydrase, which leads to an increased transneuronal chloride gradient, increased chloride current, and increased inhibition. (From Smith and Reynard, Textbook of Pharmacology, 1991, p337)

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

222.245

Groups

approved

Monoisotopic Weight

221.988131458

Pharmacology

Indication

For adjunctive treatment of: edema due to congestive heart failure; drug-induced edema; centrencephalic epilepsies; chronic simple (open-angle) glaucoma

Mechanism of action

The anticonvulsant activity of Acetazolamide may depend on a direct inhibition of carbonic anhydrase in the CNS, which decreases carbon dioxide tension in the pulmonary alveoli, thus increasing arterial oxygen tension. The diuretic effect depends on the inhibition of carbonic anhydrase, causing a reduction in the availability of hydrogen ions for active transport in the renal tubule lumen. This leads to alkaline urine and an increase in the excretion of bicarbonate, sodium, potassium, and water.

Absorption

Not Available

Protein binding

98%

Biotransformation

Not Available

Route of elimination

Not Available

Toxicity

Not Available

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Acetylsalicylic acid	Acetylsalicylic acid at high dose increases the effect of the carbonic anhydrase inhibitor, acetazolamide.
Bismuth Subsalicylate	The salicylate, bismuth subsalicylate, at high dose increases the effect of the carbonic anhydrase inhibitor, acetazolamide.
Brinzolamide	As both brinzolamide and acetazolamide are carbonic anhydrase inhibitors, there is an increased risk of adverse effects.The development of acid-base disorders with concurrent use of ophthalmic and oral carbonic anhydrase inhibitors has been reported. Avoid concurrent use of different carbonic anhydrase inhibitors when possible.
Cyclosporine	Acetazolamide may increase the effect and toxicity of cyclosporine.
Memantine	Possible increased levels of memantine
Tobramycin	Increased risk of nephrotoxicity
Topiramate	Additive renal carbonic anhydrase inhibition may occur increasing the risk of crystaluria and renal calculi. Increased risk of nephrolithiasis. Consider altnerate therapy.
Treprostinil	Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Triprolidine	The CNS depressants, Triprolidine and Acetazolamide, may increase adverse/toxic effects due to additivity. Monitor for increased CNS depressant effects during concomitant therapy.

Food Interactions

Drink plenty of liquids.
Take with food; at least 6 hours before bedtime.

Carbonic anhydrase 1
Name	Carbonic anhydrase 1
Gene Name	CA1
Pharmacological action	yes
Actions	inhibitor
References	Puscas I, Coltau M, Pasca R: Nonsteroidal anti-inflammatory drugs activate carbonic anhydrase by a direct mechanism of action. J Pharmacol Exp Ther. 1996 Jun;277(3):1464-6. - Pubmed Meierkord H, Grunig F, Gutschmidt U, Gutierrez R, Pfeiffer M, Draguhn A, Bruckner C, Heinemann U: Sodium bromide: effects on different patterns of epileptiform activity, extracellular pH changes and GABAergic inhibition. Naunyn Schmiedebergs Arch Pharmacol. 2000 Jan;361(1):25-32. - Pubmed Puscas I, Ifrim M, Maghiar T, Coltau M, Domuta G, Baican M, Hecht A: Indomethacin activates carbonic anhydrase and antagonizes the effect of the specific carbonic anhydrase inhibitor acetazolamide, by a direct mechanism of action. Int J Clin Pharmacol Ther. 2001 Jun;39(6):265-70. - Pubmed Puscas I, Coltau M, Baican M, Domuta G, Hecht A: Vasodilatory effect of diuretics is dependent on inhibition of vascular smooth muscle carbonic anhydrase by a direct mechanism of action. Drugs Exp Clin Res. 1999;25(6):271-9. - Pubmed Perez Velazquez JL: Bicarbonate-dependent depolarizing potentials in pyramidal cells and interneurons during epileptiform activity. Eur J Neurosci. 2003 Sep;18(5):1337-42. - Pubmed Mincione F, Scozzafava A, Supuran CT: The development of topically acting carbonic anhydrase inhibitors as antiglaucoma agents. Curr Pharm Des. 2008;14(7):649-54. - Pubmed
DTHybrid score	0.8959
Carbonic anhydrase 14
Name	Carbonic anhydrase 14
Gene Name	CA14
Pharmacological action	yes
Actions	inhibitor
References	Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score	0.4081
Carbonic anhydrase 2
Name	Carbonic anhydrase 2
Gene Name	CA2
Pharmacological action	yes
Actions	inhibitor
References	Avvaru BS, Wagner JM, Maresca A, Scozzafava A, Robbins AH, Supuran CT, McKenna R: Carbonic anhydrase inhibitors. The X-ray crystal structure of human isoform II in adduct with an adamantyl analogue of acetazolamide resides in a less utilized binding pocket than most hydrophobic inhibitors. Bioorg Med Chem Lett. 2010 Aug 1;20(15):4376-81. Epub 2010 Jun 17. - Pubmed Mincione F, Scozzafava A, Supuran CT: The development of topically acting carbonic anhydrase inhibitors as antiglaucoma agents. Curr Pharm Des. 2008;14(7):649-54. - Pubmed
DTHybrid score	1.909
Carbonic anhydrase 3
Name	Carbonic anhydrase 3
Gene Name	CA3
Pharmacological action	yes
Actions	inhibitor
References	Avvaru BS, Wagner JM, Maresca A, Scozzafava A, Robbins AH, Supuran CT, McKenna R: Carbonic anhydrase inhibitors. The X-ray crystal structure of human isoform II in adduct with an adamantyl analogue of acetazolamide resides in a less utilized binding pocket than most hydrophobic inhibitors. Bioorg Med Chem Lett. 2010 Aug 1;20(15):4376-81. Epub 2010 Jun 17. - Pubmed
DTHybrid score	0.371
Carbonic anhydrase 4
Name	Carbonic anhydrase 4
Gene Name	CA4
Pharmacological action	yes
Actions	inhibitor
References	Avvaru BS, Wagner JM, Maresca A, Scozzafava A, Robbins AH, Supuran CT, McKenna R: Carbonic anhydrase inhibitors. The X-ray crystal structure of human isoform II in adduct with an adamantyl analogue of acetazolamide resides in a less utilized binding pocket than most hydrophobic inhibitors. Bioorg Med Chem Lett. 2010 Aug 1;20(15):4376-81. Epub 2010 Jun 17. - Pubmed Mincione F, Scozzafava A, Supuran CT: The development of topically acting carbonic anhydrase inhibitors as antiglaucoma agents. Curr Pharm Des. 2008;14(7):649-54. - Pubmed
DTHybrid score	0.7132
Carbonic anhydrase 7
Name	Carbonic anhydrase 7
Gene Name	CA7
Pharmacological action	yes
Actions	inhibitor
References	Mincione F, Scozzafava A, Supuran CT: The development of topically acting carbonic anhydrase inhibitors as antiglaucoma agents. Curr Pharm Des. 2008;14(7):649-54. - Pubmed
DTHybrid score	0.5281
Aquaporin-1
Name	Aquaporin-1
Gene Name	AQP1
Pharmacological action	unknown
Actions	inhibitor
References	Xiang Y, Ma B, Li T, Yu HM, Li XJ: Acetazolamide suppresses tumor metastasis and related protein expression in mice bearing Lewis lung carcinoma. Acta Pharmacol Sin. 2002 Aug;23(8):745-51. - Pubmed Mu SM, Ji XH, Ma B, Yu HM, Li XJ: [Differential protein analysis in rat renal proximal tubule epithelial cells in response to acetazolamide and its relation with the inhibition of AQP1] Yao Xue Xue Bao. 2003 Mar;38(3):169-72. - Pubmed Ma B, Xiang Y, Mu SM, Li T, Yu HM, Li XJ: Effects of acetazolamide and anordiol on osmotic water permeability in AQP1-cRNA injected Xenopus oocyte. Acta Pharmacol Sin. 2004 Jan;25(1):90-7. - Pubmed Oshio K, Song Y, Verkman AS, Manley GT: Aquaporin-1 deletion reduces osmotic water permeability and cerebrospinal fluid production. Acta Neurochir Suppl. 2003;86:525-8. - Pubmed Xiang Y, Ma B, Li T, Gao JW, Yu HM, Li XJ: Acetazolamide inhibits aquaporin-1 protein expression and angiogenesis. Acta Pharmacol Sin. 2004 Jun;25(6):812-6. - Pubmed
DTHybrid score	0.3938

Cytochrome P450 3A4
Name	Cytochrome P450 3A4
Gene Name	CYP3A4
Actions	inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.3949

Solute carrier family 22 member 6
Name	Solute carrier family 22 member 6
Gene Name	SLC22A6
Actions	inhibitor
References	Uwai Y, Saito H, Hashimoto Y, Inui KI: Interaction and transport of thiazide diuretics, loop diuretics, and acetazolamide via rat renal organic anion transporter rOAT1. J Pharmacol Exp Ther. 2000 Oct;295(1):261-5. - Pubmed
DTHybrid score	0.4727

Id	Partner name	Gene Name	Score
3007	Carbonic anhydrase 12	CA12	0.166
4205	Carbonic anhydrase 9	CA9	0.1658
466	Solute carrier family 12 member 3	SLC12A3	0.146
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.1439
4757	Cytochrome P450 2C9	CYP2C9	0.1282
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.109
558	Solute carrier family 12 member 1	SLC12A1	0.1033
6016	Cytochrome P450 2C19	CYP2C19	0.0925
4119	Cytochrome P450 2D6	CYP2D6	0.0816
1024	Solute carrier family 22 member 11	SLC22A11	0.0788
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0782
6013	Cytochrome P450 2E1	CYP2E1	0.0754
1588	Multidrug resistance protein 1	ABCB1	0.066
6142	Solute carrier family 22 member 8	SLC22A8	0.0621
997	Protein kinase C beta type	PRKCB	0.0587
253	Sodium/potassium-transporting ATPase gamma chain	FXYD2	0.0571
1405	Thiopurine S-methyltransferase	TPMT	0.0561
4118	Cytochrome P450 3A5	CYP3A5	0.0555
634	Squalene monooxygenase	SQLE	0.0546
7196	Squalene monooxygenase	ERG1	0.0546
4200	Cytochrome P450 1A2	CYP1A2	0.0546
2408	Tyrosine-protein kinase SYK	SYK	0.0538
1970	Protein kinase C alpha type	PRKCA	0.0537
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0535
6024	Cytochrome P450 1A1	CYP1A1	0.0514
20	Prostaglandin G/H synthase 1	PTGS1	0.0494
4924	Cytochrome P450 2C8	CYP2C8	0.048
6127	Carbonic anhydrase-related protein	CA8	0.047
6129	Carbonic anhydrase-related protein 11	CA11	0.0469
6133	Sodium channel subunit beta-2	SCN2B	0.0469
6128	Carbonic anhydrase-related protein 10	CA10	0.0469
6135	Sodium channel subunit beta-4	SCN4B	0.0469
6132	Sodium channel subunit beta-1	SCN1B	0.0469
6134	Sodium channel subunit beta-3	SCN3B	0.0468
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0451
587	Serum albumin	ALB	0.0444
4784	Beta-mannosidase	manB	0.0432
6695	Beta-mannosidase	BT_0458	0.0432
2236	Casein kinase II subunit alpha	CSNK2A1	0.0417
6130	Carbonic anhydrase 13	CA13	0.0414
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0409
6107	Cytochrome P450 3A7	CYP3A7	0.039
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0384
6263	cAMP-dependent protein kinase catalytic subunit alpha	PRKACA	0.0364
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0356
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0352
2297	Genome polyprotein	Not Available	0.0337
2322	Genome polyprotein	Not Available	0.0337
2694	Genome polyprotein	Not Available	0.0337
2719	Genome polyprotein	Not Available	0.0337
2860	Genome polyprotein	Not Available	0.0337
2928	Genome polyprotein	Not Available	0.0337
3160	Genome polyprotein	Not Available	0.0337
3260	Genome polyprotein	Not Available	0.0337
4783	Genome polyprotein	Not Available	0.0337
5726	Genome polyprotein	Not Available	0.0337
5779	Genome polyprotein	Not Available	0.0337
5867	Genome polyprotein	Not Available	0.0337
6253	Genome polyprotein	Not Available	0.0337
6301	Genome polyprotein	Not Available	0.0337
6380	Genome polyprotein	Not Available	0.0337
6381	Genome polyprotein	Not Available	0.0337
6437	Genome polyprotein	Not Available	0.0337
6520	Genome polyprotein	Not Available	0.0337
6521	Genome polyprotein	Not Available	0.0337
6652	Genome polyprotein	Not Available	0.0337
6734	Genome polyprotein	Not Available	0.0337
6735	Genome polyprotein	Not Available	0.0337
6736	Genome polyprotein	Not Available	0.0337
6737	Genome polyprotein	Not Available	0.0337
6738	Genome polyprotein	Not Available	0.0337
6739	Genome polyprotein	Not Available	0.0337
6744	Genome polyprotein	Not Available	0.0337
6748	Genome polyprotein	Not Available	0.0337
6894	Genome polyprotein	Not Available	0.0337
6898	Genome polyprotein	Not Available	0.0337
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0336
2998	Sialic acid-binding Ig-like lectin 7	SIGLEC7	0.0325
6143	Solute carrier family 22 member 7	SLC22A7	0.032
6030	Cytochrome P450 2B6	CYP2B6	0.0311
290	Prostaglandin G/H synthase 2	PTGS2	0.031
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0307
3437	Eosinophil lysophospholipase	CLC	0.0303
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0297
4787	Envelope glycoprotein gp160	env	0.0295
4820	Envelope glycoprotein gp160	env	0.0295
5727	Envelope glycoprotein gp160	env	0.0295
6020	Aldehyde oxidase	AOX1	0.0283
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0282
3480	Mannan endo-1,4-beta-mannosidase	manA	0.0262
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0259
3941	Amine oxidase [flavin-containing] A	MAOA	0.025
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0242
3939	Amine oxidase [flavin-containing] B	MAOB	0.0226
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.0222
64	Neuraminidase	NA	0.022
641	Neuraminidase	NA	0.022
2676	Neuraminidase	NA	0.022
3026	Neuraminidase	NA	0.022
3519	Neuraminidase	NA	0.022
6007	Neuraminidase	NA	0.022
118	Organic cation/carnitine transporter 2	SLC22A5	0.0216
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0215
2207	Rhodopsin	RHO	0.0209
5718	Cytochrome P450 2A6	CYP2A6	0.0206
3623	Divalent-cation tolerance protein cutA	cutA	0.0206
310	Solute carrier family 12 member 2	SLC12A2	0.0206
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.0203
3923	Cholinesterase	BCHE	0.0191
862	Multidrug resistance-associated protein 1	ABCC1	0.0189
4785	Ig gamma-1 chain C region	IGHG1	0.0187
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.0186
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.018
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0177
2164	Multidrug resistance-associated protein 4	ABCC4	0.0177
633	Penicillin-binding proteins 1A/1B	pbpA	0.0169
871	Glucocorticoid receptor	NR3C1	0.0163
492	Histamine H1 receptor	HRH1	0.0158
404	DNA gyrase subunit A	gyrA	0.0158
6224	DNA gyrase subunit A	gyrA	0.0158
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0152
6012	Tryptophan 2,3-dioxygenase	TDO2	0.0145
6145	Solute carrier family 22 member 1	SLC22A1	0.0142
3426	Glutamine synthetase	glnA	0.0138
3987	Glutamine synthetase	GLUL	0.0138
3811	Cytochrome P450 19A1	CYP19A1	0.0135
3226	UPF0234 protein HI1034	HI_1034	0.0135
3384	Macrophage migration inhibitory factor	MIF	0.0132
776	Bile salt export pump	ABCB11	0.013
338	DNA polymerase	UL30	0.0128
379	DNA polymerase	UL54	0.0128
697	DNA polymerase	ORF28	0.0128
2482	DNA polymerase	43	0.0128
4104	DNA polymerase	BALF5	0.0128
6144	Solute carrier family 22 member 2	SLC22A2	0.0123
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0123
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0122
308	30S ribosomal protein S12	rpsL	0.0122
6704	30S ribosomal protein S12	rpsL	0.0122
1181	Alpha-1-acid glycoprotein 1	ORM1	0.012
6106	Cytochrome P450 2C18	CYP2C18	0.0116
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0112
723	Cytosolic phospholipase A2	PLA2G4A	0.0111
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.011
4790	Glycosyltransferase GtfA	gtfA	0.011
3105	M-phase inducer phosphatase 2	CDC25B	0.0108
645	Penicillin-binding protein 1A	mrcA	0.0107
5805	Penicillin-binding protein 1A	ponA	0.0107
6185	Penicillin-binding protein 1A	mrcA	0.0107
6799	Penicillin-binding protein 1A	pbpA	0.0107
136	Estrogen receptor	ESR1	0.0107
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0105
3639	Thymidine phosphorylase	deoA	0.0103
3936	Thymidine phosphorylase	TYMP	0.0103
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0101
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.01
140	30S ribosomal protein S9	rpsI	0.01
6719	30S ribosomal protein S9	rpsI	0.01
6725	30S ribosomal protein S9	rpsI	0.01
738	Monocarboxylate transporter 1	SLC16A1	0.0097
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0096
5849	cAMP-dependent protein kinase type I-alpha regulatory subunit	PRKAR1A	0.0092
556	Alpha-1A adrenergic receptor	ADRA1A	0.0091
1244	Low-density lipoprotein receptor-related protein 2	LRP2	0.009
824	Sodium-dependent serotonin transporter	SLC6A4	0.0088
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0088
731	HIV-1 protease	HIV-1 protease	0.0087
847	Mu-type opioid receptor	OPRM1	0.0084
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0083
833	Organic cation/carnitine transporter 1	SLC22A4	0.0083
477	DNA topoisomerase 4 subunit A	parC	0.0083
886	DNA topoisomerase 4 subunit A	parC	0.0083
6226	DNA topoisomerase 4 subunit A	parC	0.0083
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0082
2016	Dipeptidase 1	DPEP1	0.0082
22	30S ribosomal protein S4	rpsD	0.0081
6714	30S ribosomal protein S4	rpsD	0.0081
232	Corticosteroid-binding globulin	SERPINA6	0.008
817	DNA topoisomerase 2-alpha	TOP2A	0.008
318	Alpha-2A adrenergic receptor	ADRA2A	0.008
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0079
543	Penicillin-binding protein 1B	mrcB	0.0077
6186	Penicillin-binding protein 1B	ponB	0.0077
6822	Penicillin-binding protein 1b	pbp1b	0.0077
6844	Penicillin-binding protein 1b	pbp1b	0.0077
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0075
831	D(2) dopamine receptor	DRD2	0.0075
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0074
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0072
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.007
467	Delta-type opioid receptor	OPRD1	0.007
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0069
260	Cytochrome P450 51	ERG11	0.0069
761	Cytochrome P450 51	ERG11	0.0069
3163	Cytochrome P450 51	cyp51	0.0069
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0068
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0068
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0068
3627	UPF0190 protein yedY	yedY	0.0067
1392	Catenin beta-1	CTNNB1	0.0067
3352	Structural polyprotein	Not Available	0.0067
3628	Structural polyprotein	Not Available	0.0067
4892	Structural polyprotein	Not Available	0.0067
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0066
373	Transthyretin	TTR	0.0065
6136	Multidrug resistance-associated protein 5	ABCC5	0.0065
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0063
2320	Thymidine kinase, cytosolic	TK1	0.0062
614	Progesterone receptor	PGR	0.0062
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0062
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0061
6148	Multidrug resistance-associated protein 7	ABCC10	0.0061
5626	Nucleoside diphosphate kinase B	NME2	0.006
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.006
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.006
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0059
1898	Cytochrome P450 1B1	CYP1B1	0.0059
818	50S ribosomal protein L10	rplJ	0.0058
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0058
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0058
6043	Putative G-protein coupled receptor 44	GPR44	0.0058
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0058
6031	Cytochrome P450 3A43	CYP3A43	0.0058
632	Alpha-1B adrenergic receptor	ADRA1B	0.0057
6147	Solute carrier family 22 member 3	SLC22A3	0.0057
23	D(1A) dopamine receptor	DRD1	0.0057
696	Kappa-type opioid receptor	OPRK1	0.0055
6141	Sodium/bile acid cotransporter	SLC10A1	0.0055
275	Arachidonate 5-lipoxygenase	ALOX5	0.0055
3932	Glutathione S-transferase A2	GSTA2	0.0053
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0053
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.0053
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0053
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0052
146	Androgen receptor	AR	0.0052
438	Taste receptor type 1 member 2	TAS1R2	0.0051
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0051
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.005
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.005
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.005
277	Purine nucleoside phosphorylase	PNP	0.0049
2870	Purine nucleoside phosphorylase	punA	0.0049
2945	Purine nucleoside phosphorylase	punA	0.0049
4659	Purine nucleoside phosphorylase	TM_1596	0.0049
4825	Purine nucleoside phosphorylase	TTHA1435	0.0049
5294	Nucleoside diphosphate kinase A	NME1	0.0048
766	Beta-2 adrenergic receptor	ADRB2	0.0048
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0048
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0048
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0048
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0048
24	Thymidylate synthase	TMP1	0.0047
359	Thymidylate synthase	TYMS	0.0047
2626	Thymidylate synthase	thyA	0.0047
2729	Thymidylate synthase	thyA	0.0047
5352	Thymidylate synthase	THYA	0.0047
789	Alpha-1D adrenergic receptor	ADRA1D	0.0047
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0047
713	Sodium-dependent dopamine transporter	SLC6A3	0.0046
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0046
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0046
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0045
629	Alpha-2B adrenergic receptor	ADRA2B	0.0045
3686	Acyl-CoA thioesterase I precursor	tesA	0.0045
6339	Ig kappa chain V-II region RPMI 6410	Not Available	0.0044
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0043
5698	Riboflavin synthase alpha chain	ribE	0.0043
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0042
378	Alpha-2C adrenergic receptor	ADRA2C	0.0042
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0042
115	Penicillin-binding protein 2	mrdA	0.0041
6069	Penicillin-binding protein 2	mrdA	0.0041
6118	Penicillin-binding protein 2	penA	0.0041
6187	Penicillin-binding protein 2	pbpA	0.0041
6686	Penicillin-binding protein 2	pbp2	0.0041
6939	Penicillin-binding protein 2	mrdA	0.0041
7163	Penicillin-binding protein 2	pbpA	0.0041
887	DNA gyrase subunit B	gyrB	0.0041
4150	DNA gyrase subunit B	gyrB	0.0041
6225	DNA gyrase subunit B	gyrB	0.0041
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0041
408	Riboflavin kinase	RFK	0.0041
244	Angiotensin-converting enzyme	ACE	0.0041
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0041
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0041
638	D(3) dopamine receptor	DRD3	0.0041
29	Tubulin beta-1 chain	TUBB1	0.004
952	Dipeptidyl peptidase 4	DPP4	0.004
725	5-hydroxytryptamine 1D receptor	HTR1D	0.004
315	Arginase-1	ARG1	0.004
1558	Transient receptor potential cation channel subfamily V member 1	TRPV1	0.004
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0039
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0039
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0039
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0039
1129	C-C chemokine receptor type 5	CCR5	0.0039
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0039
1	Peptidoglycan synthetase ftsI	ftsI	0.0038
4155	Peptidoglycan synthetase ftsI	ftsI	0.0038
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0038
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0038
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0038
6014	Cytochrome P450 2A13	CYP2A13	0.0038
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0038
5353	Glutamate decarboxylase alpha	gadA	0.0037
6149	Solute carrier family 22 member 10	SLC22A10	0.0036
6182	Cytochrome P450 2J2	CYP2J2	0.0036
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0036
1867	Major prion protein	PRNP	0.0036
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0036
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0036
68	Cannabinoid receptor 1	CNR1	0.0036
122	P2Y purinoceptor 12	P2RY12	0.0035
856	Vitamin D3 receptor	VDR	0.0035
4237	50S ribosomal protein L22	rplV	0.0035
185	Vasopressin V1a receptor	AVPR1A	0.0035
4773	Deoxycytidine kinase	DCK	0.0035
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0035
1757	Myeloperoxidase	MPO	0.0035
889	3-oxoacyl-[acyl-carrier-protein] synthase 1	fabB	0.0035
6860	3-oxoacyl-[acyl-carrier-protein] synthase 1	kasA	0.0035
939	50S ribosomal protein L3	rplC	0.0035
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0035
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0035
811	Translocator protein	TSPO	0.0035
322	Vasopressin V2 receptor	AVPR2	0.0034
193	Beta-1 adrenergic receptor	ADRB1	0.0034
161	Tubulin beta chain	TUBB	0.0034
312	Tubulin beta chain	TUB2	0.0034
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0034
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0034
65	Matrix metalloproteinase-9	Not Available	0.0033
474	Acetylcholinesterase	ACHE	0.0033
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.0033
70	Type-1 angiotensin II receptor	AGTR1	0.0033
6137	Multidrug resistance-associated protein 6	ABCC6	0.0033
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0033
814	Ryanodine receptor 1	RYR1	0.0033
332	Beta-lactamase	blaZ	0.0033
2478	Beta-lactamase	ampC	0.0033
2613	Beta-lactamase	ampC	0.0033
2635	Beta-lactamase	ampC	0.0033
2700	Beta-lactamase	penP	0.0033
5445	Beta-lactamase	blaB	0.0033
6019	Beta-lactamase	SHV-7	0.0033
6701	Beta-lactamase	cphA	0.0033
468	Cytochrome P450 4A11	CYP4A11	0.0033
130	Prostacyclin synthase	PTGIS	0.0033
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0032
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0032
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0032
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0032
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0032
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0032
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0032
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0032
380	Cytochrome P450 17A1	CYP17A1	0.0032
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0031
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0031
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0031
6207	30S ribosomal protein S14	rpsN	0.0031
432	D(4) dopamine receptor	DRD4	0.0031
6209	30S ribosomal protein S19	rpsS	0.0031
6712	30S ribosomal protein S19	rpsS	0.0031
6726	30S ribosomal protein S19	rpsS	0.0031
342	P protein [Includes: DNA-directed DNA polymerase	P	0.0031
612	P protein [Includes: DNA-directed DNA polymerase	P	0.0031
2578	Tubulin beta-3 chain	TUBB3	0.003
2285	Streptogramin A acetyltransferase	vatD	0.003
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.003
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.003
4604	Liver carboxylesterase 1	CES1	0.003
716	5-hydroxytryptamine 7 receptor	HTR7	0.003
654	Flavin reductase	BLVRB	0.0029
756	Sex hormone-binding globulin	SHBG	0.0029
284	DNA-directed RNA polymerase beta chain	rpoB	0.0029
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0029
6167	Organic solute transporter subunit beta	OSTB	0.0028
3688	Branched-chain-amino-acid aminotransferase	ilvE	0.0028
6166	Organic solute transporter subunit alpha	OSTA	0.0028
4252	Penicillin-binding protein 5	dacA	0.0028
159	Penicillin-binding protein 2B	penA	0.0028
6121	Penicillin-binding protein 2B	penA	0.0028
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0028
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0028
6102	Arylamine N-acetyltransferase 2	NAT2	0.0028
1196	Complement decay-accelerating factor	CD55	0.0027
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0027
4173	Tyrosine-protein kinase JAK2	JAK2	0.0027
3685	Catabolite gene activator	crp	0.0027
4655	Adenylate cyclase	cyaC	0.0027
4759	Adenylate cyclase	cyaB2	0.0027
1050	Bile salt sulfotransferase	SULT2A1	0.0026
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0026
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0026
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0026
293	Gamma-glutamyl hydrolase	GGH	0.0026
49	Endothelin B receptor	EDNRB	0.0026
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0025
509	Thymidine kinase	TK	0.0025
570	Thymidine kinase	TK	0.0025
2559	Thymidine kinase	TK	0.0025
3430	Thymidine kinase	tdk	0.0025
3518	Thymidine kinase	TK	0.0025
5301	Thymidine kinase	tdk	0.0025
5771	Thymidine kinase	ORF36	0.0025
7009	Thymidine kinase	ORF36	0.0025
407	Vascular endothelial growth factor receptor 2	KDR	0.0025
3947	Xanthine dehydrogenase/oxidase	XDH	0.0025
459	Retinoic acid receptor RXR-alpha	RXRA	0.0025
707	72 kDa type IV collagenase	MMP2	0.0025
768	FK506-binding protein 1A	FKBP1A	0.0025
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0024
705	Glutamate receptor 1	GRIA1	0.0024
124	Histamine H2 receptor	HRH2	0.0024
578	Endothelin-1 receptor	EDNRA	0.0024
544	Potassium voltage-gated channel subfamily E member 1	KCNE1	0.0024
2808	Chloramphenicol acetyltransferase 3	cat3	0.0024
1714	Mitogen-activated protein kinase 3	MAPK3	0.0024
1483	Membrane copper amine oxidase	AOC3	0.0024
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0024
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0024
471	Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)	SLC6A14	0.0024
183	Vascular endothelial growth factor A	VEGFA	0.0024
5852	Type-2 angiotensin II receptor	AGTR2	0.0024
642	3-oxo-5-alpha-steroid 4-dehydrogenase 2	SRD5A2	0.0023
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0023
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0023
2249	Aspartate aminotransferase	aspC	0.0023
2671	Aspartate aminotransferase	aspC	0.0023
5490	Aspartate aminotransferase	Not Available	0.0023
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0023
844	Epidermal growth factor receptor	EGFR	0.0023
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0023
777	Tumor necrosis factor	TNF	0.0023
1650	Heme carrier protein 1	SLC46A1	0.0023
869	Estrogen receptor beta	ESR2	0.0023
4760	Mll3241 protein	mll3241	0.0023
737	Mineralocorticoid receptor	NR3C2	0.0022
504	Mast/stem cell growth factor receptor	KIT	0.0022
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0022
2417	Chloramphenicol acetyltransferase	cat	0.0022
3278	Chloramphenicol acetyltransferase	cat	0.0022
2810	Dr hemagglutinin structural subunit	draA	0.0022
6220	Aryl hydrocarbon receptor	AHR	0.0022
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0022
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0022
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0022
2449	Tubulin alpha-3 chain	TUBA1A	0.0021
298	Renin	REN	0.0021
6506	Stathmin-4	STMN4	0.0021
6033	High affinity interleukin-8 receptor A	CXCR1	0.0021
718	Folate receptor gamma	FOLR3	0.0021
299	Folate receptor beta	FOLR2	0.0021
804	Mitochondrial folate transporter/carrier	SLC25A32	0.0021
1656	CYP2B protein	CYP2B	0.0021
1198	Serum paraoxonase/arylesterase 1	PON1	0.0021
6223	Penicillin-binding protein 1C	pbpC	0.0021
163	D(1B) dopamine receptor	DRD5	0.0021
527	Prostacyclin receptor	PTGIR	0.0021
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.0021
2539	Tubulin alpha-1 chain	TUBA4A	0.0021
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0021
672	Prostaglandin F2-alpha receptor	PTGFR	0.002
465	Calmodulin	CALM1	0.002
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.002
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.002
867	Penicillin-binding protein 3	pbpC	0.0019
6119	Penicillin-binding protein 3	pbp3	0.0019
7154	Penicillin-binding protein 3	pbp3	0.0019
7157	Penicillin-binding protein 3	LMHCC_2184	0.0019
7162	Penicillin-binding protein 3	pbpB	0.0019
7172	Penicillin-binding protein 3	pbp3	0.0019
2499	Tubulin beta-2C chain	TUBB2C	0.0019
233	Potassium channel subfamily K member 2	KCNK2	0.0019
1654	Interleukin-1 beta	IL1B	0.0019
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0019
4120	NADPH--cytochrome P450 reductase	POR	0.0018
5998	Toll-like receptor 8	TLR8	0.0018
26	Vascular endothelial growth factor receptor 3	FLT4	0.0018
4238	50S ribosomal protein L4	rplD	0.0018
5578	50S ribosomal protein L4	rplD	0.0018
6173	50S ribosomal protein L4	rplD	0.0018
6219	50S ribosomal protein L4	rplD	0.0018
712	Tubulin alpha chain	TUB1	0.0018
1968	ATP-sensitive inward rectifier potassium channel 12	KCNJ12	0.0018
565	Extracellular calcium-sensing receptor	CASR	0.0018
4217	Telomerase reverse transcriptase	TERT	0.0018
683	Potassium transporter	GK0582	0.0018
53	Solute carrier family 12 member 5	SLC12A5	0.0018
663	Solute carrier family 12 member 4	SLC12A4	0.0018
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0018
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0017
613	Atrial natriuretic peptide receptor A	NPR1	0.0017
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0017
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0017
32	Vascular endothelial growth factor receptor 1	FLT1	0.0017
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0017
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0017
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0016
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0016
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0016
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0016
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0016
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0016
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0016
1852	Microtubule-associated protein 2	MAP2	0.0016
365	Dihydrofolate reductase	DHFR	0.0016
2381	Dihydrofolate reductase	DFR1	0.0016
2833	Dihydrofolate reductase	Not Available	0.0016
2931	Dihydrofolate reductase	folA	0.0016
3544	Dihydrofolate reductase	folA	0.0016
3682	Dihydrofolate reductase	folA	0.0016
6642	Dihydrofolate reductase	folA	0.0016
6756	Dihydrofolate reductase	dfrA	0.0016
173	Toll-like receptor 7	TLR7	0.0016
1192	Sulfotransferase 1A1	SULT1A1	0.0016
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0016
3233	Bile acid receptor	NR1H4	0.0015
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0015
494	Caspase-1	CASP1	0.0015
6138	Multidrug resistance protein 3	ABCB4	0.0015
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0015
1507	Cytochrome c	CYCS	0.0015
427	Substance-P receptor	TACR1	0.0015
1629	Transcription factor AP-1	JUN	0.0015
581	Cytochrome P450 2R1	CYP2R1	0.0015
1541	Metalloproteinase	mmp20	0.0014
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0014
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0014
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0014
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0014
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.0014
3760	Penicillin-binding protein 5 precursor	dacA	0.0014
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0014
1010	Cytochrome P450 51A1	CYP51A1	0.0014
273	Apoptosis regulator Bcl-2	BCL2	0.0014
822	Aldose reductase	AKR1B1	0.0014
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0013
677	Choline-phosphate cytidylyltransferase A	PCYT1A	0.0013
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0013
1353	DNA topoisomerase 1	TOP1	0.0013
3552	DNA topoisomerase 1	topA	0.0013
6085	Fatty acid-binding protein, intestinal	FABP2	0.0013
6184	D-alanyl-D-alanine carboxypeptidase dacC	dacC	0.0013
4122	Histone deacetylase 2	HDAC2	0.0013
2077	Caspase-3	CASP3	0.0013
1275	Estrogen sulfotransferase	SULT1E1	0.0013
891	Dihydropteroate synthase	folP	0.0013
5359	Dihydropteroate synthase	folP	0.0013
7175	Dihydropteroate synthase	sulI	0.0013
6116	Gastric triacylglycerol lipase	LIPF	0.0012
819	Penicillin-binding protein 4	dacB	0.0012
780	Retinoic acid receptor RXR-gamma	RXRG	0.0012
16	Adenosine A1 receptor	ADORA1	0.0012
6218	Pannexin-1	PANX1	0.0012
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0012
3823	Cytokine receptor common gamma chain	IL2RG	0.0012
85	Growth hormone receptor	GHR	0.0012
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0012
1039	Histone deacetylase 9	HDAC9	0.0012
2107	Microtubule-associated protein 1A	MAP1A	0.0012
571	Melatonin receptor type 1A	MTNR1A	0.0012
362	Melatonin receptor type 1B	MTNR1B	0.0012
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0012
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0012
1295	Fatty acid synthase	FASN	0.0012
904	Glutathione S-transferase P	GSTP1	0.0012
702	UMP-CMP kinase	CMPK1	0.0012
482	Glycine receptor subunit alpha-1	GLRA1	0.0012
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0012
1178	Adenosine A2a receptor	ADORA2A	0.0011
2021	Thrombomodulin	THBD	0.0011
239	Coagulation factor X	F10	0.0011
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0011
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0011
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0011
88	Retinoic acid receptor RXR-beta	RXRB	0.0011
2461	D-alanyl-D-alanine carboxypeptidase	Not Available	0.0011
5756	D-alanyl-D-alanine carboxypeptidase	dac	0.0011
921	Glutamate receptor 2	GRIA2	0.0011
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0011
754	Pancreatic triacylglycerol lipase	PNLIP	0.0011
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0011
5787	Angiopoietin-1 receptor	TEK	0.0011
3810	Catechol O-methyltransferase	COMT	0.0011
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0011
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0011
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0011
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0011
2178	Metabotropic glutamate receptor 5	GRM5	0.0011
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0011
724	Interleukin-2 receptor alpha chain	IL2RA	0.0011
717	Interleukin-2 receptor subunit beta	IL2RB	0.0011
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0011
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0011
54	Prothrombin	F2	0.001
1810	Protein S100-A1	S100A1	0.001
6097	Protein S100-A2	S100A2	0.001
4203	Histamine N-methyltransferase	HNMT	0.001
4116	Dihydropteroate synthetase	Not Available	0.001
4228	Keratin, type II cytoskeletal 7	KRT7	0.001
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.001
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.001
1144	Hepatocyte growth factor receptor	MET	0.001
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.001
493	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	0.001
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.001
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.001
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.001
512	DNA-directed RNA polymerase alpha chain	rpoA	0.001
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.001
5300	Antigen peptide transporter 1	TAP1	0.001
4041	Microsomal glutathione S-transferase 2	MGST2	0.001
6824	Tyrosine-protein kinase Lyn	LYN	0.001
33	Cystine/glutamate transporter	SLC7A11	0.001
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.001
605	Fumarate reductase flavoprotein subunit	frdA	0.001
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.001
3673	Fumarate reductase flavoprotein subunit	fccA	0.001
4912	Fumarate reductase flavoprotein subunit	ifcA	0.001
6549	Fumarate reductase flavoprotein subunit	frdA	0.001
2268	Cholesterol oxidase	choB	0.0009
2822	Cholesterol oxidase	choA	0.0009
1517	Beta-3 adrenergic receptor	ADRB3	0.0009
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0009
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0009
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0009
6105	3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	0.0009
3086	Plasmepsin-2	Not Available	0.0009
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0009
165	FL cytokine receptor	FLT3	0.0009
1048	Protein S100-A13	S100A13	0.0009
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0009
2226	Protein S100-A12	S100A12	0.0009
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0009
1770	Phospholipase C	PLCL1	0.0009
2841	Phospholipase C	plc	0.0009
1648	Elastin	ELN	0.0009
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0009
2283	Steroid Delta-isomerase	ksi	0.0009
2920	Steroid Delta-isomerase	ksi	0.0009
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.0009
153	Dopamine beta-hydroxylase	DBH	0.0009
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0009
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0009
390	Adenosine A3 receptor	ADORA3	0.0009
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0009
2132	Protein S100-B	S100B	0.0009
3404	Exotoxin A	eta	0.0008
5818	Folate receptor alpha	FOLR1	0.0008
6042	Prostaglandin reductase 2	PTGR2	0.0008
4037	Hypothetical protein	GPX1	0.0008
4297	Hypothetical protein	SP_1951	0.0008
4521	Hypothetical protein	BC_2969	0.0008
4540	Hypothetical protein	TM_1070	0.0008
4555	Hypothetical protein	MT1739	0.0008
4569	Hypothetical protein	mshD	0.0008
4578	Hypothetical protein	PA3270	0.0008
4747	Hypothetical protein	PA3967	0.0008
5177	Hypothetical protein	TM_0096	0.0008
5194	Hypothetical protein	PA1204	0.0008
5240	Hypothetical protein	Rv2991	0.0008
5370	Hypothetical protein	TM_1158	0.0008
5710	Hypothetical protein	Tb927.5.1360	0.0008
4527	Putative hydrolase ycdX	ycdX	0.0008
4536	Transcriptional regulator, IclR family	TM_0065	0.0008
2501	Protein ygbM	ygbM	0.0008
4545	Molybdopterin-converting factor subunit 2	moaE	0.0008
4522	Arginine N-succinyltransferase subunit alpha	astA	0.0008
4106	Guanylate kinase	GUK1	0.0008
4516	Guanylate kinase	gmk	0.0008
4538	Hypothetical protein VC1899	VC_1899	0.0008
4529	Oxalate decarboxylase oxdC	oxdC	0.0008
4514	Citrate lyase beta subunit-like protein	citE	0.0008
4781	Citrate lyase beta subunit-like protein	DR_1240	0.0008
4526	Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein	TM_1223	0.0008
4524	Mannose-6-phosphate isomerase	yvyI	0.0008
4535	Glutaconyl-CoA decarboxylase subunit alpha	gcdA	0.0008
4547	Iron binding protein FbpA	fbpA	0.0008
4548	Gyrase B	gyrB	0.0008
4546	Aminotransferase, putative	TM_1131	0.0008
658	Para-aminobenzoate synthase component 1	pabB	0.0008
4515	Peripheral plasma membrane protein CASK	CASK	0.0008
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0008
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0008
94	5-hydroxytryptamine 4 receptor	HTR4	0.0008
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.0008
3587	Gastrotropin	FABP6	0.0008
2232	Interleukin-5	IL5	0.0008
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0008
1593	Mucin-2	MUC2	0.0008
4031	Glutathione S-transferase A1	GSTA1	0.0008
1792	Tissue-type plasminogen activator	PLAT	0.0008
760	Fibroblast growth factor 1	FGF1	0.0008
6432	Transporter	snf	0.0008
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0008
489	Monocarboxylate transporter 2	SLC16A7	0.0008
1649	Small inducible cytokine A2	CCL2	0.0008
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0008
3856	Fibroblast growth factor receptor 3	FGFR3	0.0008
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0008
2091	Endoplasmin	HSP90B1	0.0008
4496	C-terminal-binding protein 1	CTBP1	0.0008
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.0007
896	Glutathione S-transferase Mu 1	GSTM1	0.0007
473	L-lactate dehydrogenase A chain	LDHA	0.0007
461	Glycine receptor subunit alpha-3	GLRA3	0.0007
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0007
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0007
6103	Arylamine N-acetyltransferase 1	NAT1	0.0007
4517	Probable butyrate kinase 2	buk2	0.0007
3261	Signal recognition particle protein	ffh	0.0007
4528	Phenazine biosynthesis protein PhzD	phzD1	0.0007
4533	Glyoxalase family protein	BC_1747	0.0007
56	Delta-aminolevulinic acid dehydratase	ALAD	0.0007
2356	Delta-aminolevulinic acid dehydratase	hemB	0.0007
3613	Delta-aminolevulinic acid dehydratase	hemB	0.0007
3674	Delta-aminolevulinic acid dehydratase	hemB	0.0007
3759	Glutathione S-transferase	gst	0.0007
4541	Glutathione S-transferase	GST	0.0007
4542	Glutaminase 1	glsA1	0.0007
4544	Glutaminase 1	glsA1	0.0007
2929	(S)-2-haloacid dehalogenase	dhlB	0.0007
2995	(S)-2-haloacid dehalogenase	Not Available	0.0007
3237	Beta-lactamase OXA-2	bla	0.0007
4532	Gephyrin	GPHN	0.0007
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.0007
2112	Toll-like receptor 9	TLR9	0.0007
469	Annexin A1	ANXA1	0.0007
5924	Microtubule-associated protein 4	MAP4	0.0007
5923	Microtubule-associated protein tau	MAPT	0.0007
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0007
2298	Cytochrome P450-cam	camC	0.0007
518	Peroxidase/catalase T	katG	0.0007
2290	ADP-ribosyl cyclase 2	BST1	0.0007
226	Gonadotropin-releasing hormone receptor	GNRHR	0.0007
1830	5'-nucleotidase	NT5E	0.0007
164	Histamine H4 receptor	HRH4	0.0007
125	DNA polymerase beta	POLB	0.0007
4531	Putative ketoacyl reductase	actIII	0.0007
2775	Dihydroorotate dehydrogenase	pyrD	0.0007
3467	Methylglyoxal synthase	mgsA	0.0007
3583	6-phosphogluconolactonase	pgl	0.0007
1618	High affinity nerve growth factor receptor	NTRK1	0.0007
4311	tRNA	TRDMT1	0.0007
4325	tRNA	trmD	0.0007
4328	tRNA	trmD	0.0007
131	Synaptic vesicular amine transporter	SLC18A2	0.0007
1123	Eosinophil cationic protein	RNASE3	0.0007
2599	Tyrosine-protein kinase HCK	HCK	0.0007
3937	Fatty-acid amide hydrolase	FAAH	0.0006
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0006
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0006
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0006
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0006
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0006
1313	Lactoylglutathione lyase	GLO1	0.0006
144	Hemoglobin subunit alpha	HBA1	0.0006
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0006
106	Cannabinoid receptor 2	CNR2	0.0006
2525	3-phosphoshikimate 1-carboxyvinyltransferase	aroA	0.0006
3201	3-phosphoshikimate 1-carboxyvinyltransferase	aroA	0.0006
6174	50S ribosomal protein L32	rpmF	0.0006
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0006
3809	Estrogen-related receptor gamma	ESRRG	0.0006
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0006
76	Nitric-oxide synthase, brain	NOS1	0.0006
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0006
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0006
2688	Peptide deformylase	def	0.0006
2708	Peptide deformylase	def	0.0006
3004	Peptide deformylase	def	0.0006
4337	Peptide deformylase	def	0.0006
4338	Peptide deformylase	def	0.0006
5368	Peptide deformylase	def	0.0006
5371	Peptide deformylase	def	0.0006
6375	Peptide deformylase	def	0.0006
6378	Peptide deformylase	def	0.0006
6379	Peptide deformylase	def	0.0006
6776	Peptide deformylase	def	0.0006
6900	Peptide deformylase	def	0.0006
4534	Cytohesin-2	CYTH2	0.0006
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0006
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0006
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0006
563	Thyroid peroxidase	TPO	0.0006
4192	DNA topoisomerase 2-beta	TOP2B	0.0006
2548	Subtilisin Carlsberg	apr	0.0006
4269	Hypoxanthine-guanine phosphoribosyltransferase, putative	HGPRTase	0.0006
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.0006
3611	Cytidine deaminase	cdd	0.0006
3707	Cytidine deaminase	cdd	0.0006
4211	Cytidine deaminase	CDA	0.0006
936	Ephrin type-A receptor 2	EPHA2	0.0006
1291	cAMP response element-binding protein	CREB1	0.0006
1569	G1/S-specific cyclin-D1	CCND1	0.0006
1525	Heparin-binding growth factor 2	FGF2	0.0006
4210	Toll-like receptor 4	TLR4	0.0005
810	Heme oxygenase 1	HMOX1	0.0005
3391	Heme oxygenase 1	pbsA1	0.0005
1341	Histamine H3 receptor	HRH3	0.0005
84	Nuclear receptor 0B1	NR0B1	0.0005
1760	Aminopeptidase N	ANPEP	0.0005
6843	Aminopeptidase N	pepN	0.0005
1262	Corticotropin-lipotropin	POMC	0.0005
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0005
117	Sterol O-acyltransferase 1	SOAT1	0.0005
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0005
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0005
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0005
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0005
6211	Tubulin epsilon chain	TUBE1	0.0005
6212	Tubulin gamma-1 chain	TUBG1	0.0005
6210	Tubulin delta chain	TUBD1	0.0005
823	Fibroblast growth factor receptor 2	FGFR2	0.0005
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0005
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0005
3027	Streptavidin	Not Available	0.0005
3601	Dihydropteroate synthase 1	folP1	0.0005
3807	Dihydropteroate synthase 1	folP1	0.0005
3808	Dihydropteroate synthase 2	folP2	0.0005
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0005
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0005
500	Monocarboxylate transporter 4	SLC16A3	0.0005
7	Nitric oxide synthase, inducible	NOS2	0.0005
3913	Glutamic acid decarboxylase	GAD65	0.0005
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0004
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0004
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0004
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0004
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0004
1992	Vitamin D-binding protein	GC	0.0004
319	Opioid receptor, sigma 1	OPRS1	0.0004
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0004
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0004
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0004
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0004
5682	Ribonuclease pancreatic	RNASE1	0.0004
4103	Proteasome subunit beta type 2	PSMB2	0.0004
4101	Proteasome subunit beta type 1	PSMB1	0.0004
4102	Proteasome subunit beta type 5	PSMB5	0.0004
1630	Integrin beta-2	ITGB2	0.0004
976	Platelet glycoprotein IX	GP9	0.0004
1374	Natriuretic peptides B	NPPB	0.0004
1827	Gap junction alpha-1 protein	GJA1	0.0004
1908	Vascular cell adhesion protein 1	VCAM1	0.0004
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0004
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0004
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0004
2216	Fibroblast growth factor receptor 4	FGFR4	0.0004
735	Alanine aminotransferase 1	GPT	0.0004
3904	Alanine aminotransferase 2	GPT2	0.0004
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0004
1176	Mitogen-activated protein kinase 1	MAPK1	0.0004
6146	High affinity copper uptake protein 1	SLC31A1	0.0004
251	Alcohol dehydrogenase 1A	ADH1A	0.0004
174	Sigma 1-type opioid receptor	SIGMAR1	0.0004
594	Thyroxine-binding globulin	SERPINA7	0.0004
6048	Troponin C, skeletal muscle	TNNC2	0.0004
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0004
719	Retinoic acid receptor responder protein 1	RARRES1	0.0003
770	Retinoic acid-induced protein 3	GPRC5A	0.0003
820	Glycine receptor subunit alpha-2	GLRA2	0.0003
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0003
268	Adenosine A2b receptor	ADORA2B	0.0003
828	Phenylalanine-4-hydroxylase	PAH	0.0003
3109	Phenylalanine-4-hydroxylase	phhA	0.0003
6044	Serum paraoxonase/lactonase 3	PON3	0.0003
758	Thyroid hormone receptor alpha	THRA	0.0003
444	Alcohol dehydrogenase 1B	ADH1B	0.0003
484	Tyrosine-protein kinase ABL2	ABL2	0.0003
2240	Cell division protein kinase 2	CDK2	0.0003
572	Integrin alpha-L	ITGAL	0.0003
5798	Mitogen-activated protein kinase 11	MAPK11	0.0003
199	Monocarboxylate transporter 8	SLC16A2	0.0003
291	Nitric-oxide synthase, endothelial	NOS3	0.0003
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0003
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0003
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0003
569	Retinal dehydrogenase 2	ALDH1A2	0.0003
267	Plasminogen activator inhibitor 1	SERPINE1	0.0003
1864	RET proto-oncogene	RET	0.0003
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0003
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0003
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0003
346	Thyroid hormone receptor beta-1	THRB	0.0003
611	Retinal dehydrogenase 1	ALDH1A1	0.0003
517	Alcohol dehydrogenase 1C	ADH1C	0.0003
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0003
1268	Neuropeptide S receptor	NPSR1	0.0003
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0003
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0003
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0003
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0003
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0003
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0003
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0003
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0003
6221	Steroid hormone receptor ERR1	ESRRA	0.0003
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0003
5934	Cytochrome P450 26A1	CYP26A1	0.0003
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0003
751	Potassium channel subfamily K member 6	KCNK6	0.0003
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0003
908	Glutathione S-transferase theta-1	GSTT1	0.0003
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0003
6073	Potassium channel subfamily K member 9	KCNK9	0.0003
6072	Potassium channel subfamily K member 3	KCNK3	0.0003
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0003
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0002
172	Potassium channel subfamily K member 1	KCNK1	0.0002
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0002
3957	Adenosine deaminase	ADA	0.0002
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0002
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0002
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0002
6168	Solute carrier family 22 member 16	SLC22A16	0.0002
162	Retinoic acid receptor gamma-1	RARG	0.0002
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0002
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0002
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0002
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0002
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0002
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0001
4936	Cytochrome c2 iso-2	Not Available	0.0001
4916	Cyanoglobin	glbN	0.0001
4994	Hemoglobin-like protein HbO	glbO	0.0001
4915	Cytochrome c-550	psbV	0.0001
4959	Cytochrome c-550	psbV	0.0001
5216	Cytochrome c-550	psbV	0.0001
4925	Cytochrome c-type protein SHP	shp	0.0001
4904	Cytochrome c family protein	GSU1996	0.0001
4943	Cytochrome c6	petJ	0.0001
3116	Bacterioferritin	bfr	0.0001
4906	Bacterioferritin	bfr	0.0001
4965	Bacterioferritin	bfr	0.0001
4954	Soluble cytochrome b558	Not Available	0.0001
4934	Cytochrome c-551	nirM	0.0001
5218	Cytochrome c-551	nirM	0.0001
4905	Cytochrome c2	Not Available	0.0001
4939	Cytochrome c2	cycA	0.0001
4964	Cytochrome c2	cycA	0.0001
4979	Cytochrome c2	cycA	0.0001
6673	Cytochrome c2	cycA	0.0001
4910	Cytoglobin	CYGB	0.0001
4984	Neuroglobin	NGB	0.0001
4981	Iron-starvation protein PigA	pigA	0.0001
4909	CooA protein	cooA	0.0001
4998	Hemoglobin-like protein yjbI	yjbI	0.0001
4935	Cytochrome c-554	cycA1	0.0001
4947	Bacterial hemoglobin	vhb	0.0001
4975	Cytochrome c-556	RPA3973	0.0001
4942	Diheme cytochrome c napB	napB	0.0001
4931	Cytochrome P450 167A1	CYP167A1	0.0001
5000	HemO	hemO	0.0001
4972	P450cin	cinA	0.0001
4960	Putative cytochrome P450-family protein	SCO7417	0.0001
4971	Nonaheme cytochrome c	hmcA	0.0001
4989	Cytochrome c551 peroxidase	ccp	0.0001
5222	Cytochrome c551 peroxidase	ccpA	0.0001
4961	Hemophore HasA	hasA	0.0001
4976	Apocytochrome f	petA	0.0001
6407	Apocytochrome f	petA	0.0001
4907	Cytochrome c-L	moxG	0.0001
6865	Cytochrome c-L	moxG	0.0001
4993	Hydroxylamine oxidoreductase	hao1	0.0001
4764	Cytochrome P450 165C4	CYP165C4	0.0001
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0001
644	Heme oxygenase 2	HMOX2	0.0001
4982	Heme oxygenase 2	pbsA2	0.0001
4952	Catalase/peroxidase	katA	0.0001
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0001
4937	Cytochrome oxidase subunit II	rcoxA	0.0001
4903	Methyl-accepting chemotaxis protein	Tar4	0.0001
4999	Cytochrome P450 165B3	CYP165B3	0.0001
3093	Catalase HPII	katE	0.0001
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0001
4922	Cytochrome c, putative	SO_4144	0.0001
4920	Peroxidase/catalase	katG	0.0001
4990	PpcA	ppcA	0.0001
4948	Cytochrome c-553	Not Available	0.0001
4923	Cytochrome c3	DvMF_2499	0.0001
4945	Cytochrome c3	Not Available	0.0001
4949	Cytochrome c3	DVU_3171	0.0001
4968	Cytochrome c3	cytc3	0.0001
4997	Cytochrome c3	SO_2727	0.0001
5219	Cytochrome c3	cyd	0.0001
2119	Cytochrome b5	CYB5A	0.0001
4902	Nine-heme cytochrome c	Ddes_2038	0.0001
3189	High-molecular-weight cytochrome c	hmcA	0.0001
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0001
3375	Acidic cytochrome c3	Not Available	0.0001
4988	Sulfite oxidase, mitochondrial	SUOX	0.0001
2915	Sensor protein fixL	fixL	0.0001
4944	Sensor protein fixL	fixL	0.0001
4813	Heme oxygenase	hmuO	0.0001
5769	Heme oxygenase	Not Available	0.0001
3570	Cytochrome P450 152A1	cypC	0.0001
4385	Cytochrome c'	Not Available	0.0001
4967	Cytochrome c'	cycA	0.0001
5038	Cytochrome c'	Not Available	0.0001
5223	Cytochrome c'	cycP	0.0001
4289	Cytochrome P450	TT_P0059	0.0001
6262	Cytochrome P450	staP	0.0001
4992	Cytochrome c peroxidase	Not Available	0.0001
2230	Catalase	CAT	0.0001
3249	Catalase	katA	0.0001
3625	Catalase	katA	0.0001
4539	Catalase	katA	0.0001
4941	Catalase	katB	0.0001
3670	Soluble cytochrome b562 precursor	cybC	0.0001
3411	Cytochrome P450 121	cyp121	0.0001
3291	Cytochrome c-552	cycA	0.0001
4927	Cytochrome c-552	nrfA	0.0001
4938	Cytochrome c-552	cycA	0.0001
4953	Cytochrome c-552	nrfA	0.0001
5217	Cytochrome c-552	cycM	0.0001
2617	Nitric oxide synthase oxygenase	nos	0.0001
2701	Nitric oxide synthase oxygenase	nos	0.0001
3102	Flavohemoprotein	hmp	0.0001
4969	Flavohemoprotein	hmp	0.0001
4386	Hemoglobin-like protein HbN	glbN	0.0001
3127	Nitrite reductase	nirS	0.0001
3284	Nitrite reductase	nirS	0.0001
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0001
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0001
3221	Cytochrome c4	cc4	0.0001
4608	Putative cytochrome P450	SCO1207	0.0001
4963	Putative cytochrome P450	SCO2884	0.0001
6254	Putative cytochrome P450	SCO6998	0.0001
358	Cystathionine beta-synthase	CBS	0
693	Hemoglobin subunit beta	HBB	0
6268	Hydroxyacid oxidase 1	HAO1	0

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB00819 - Acetazolamide

Targets

Enzymes

Transporters

Predictions