DT-Web

DB00711 - Diethylcarbamazine


Identification
Name Diethylcarbamazine
Accession Number DB00711 (APRD00918)
Type small molecule
Description An anthelmintic used primarily as the citrate in the treatment of filariasis, particularly infestations with Wucheria bancrofti or Loa loa. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 199.2932
Groups approved
Monoisotopic Weight 199.168462309
Pharmacology
Indication Used for the treatment of individual patients with certain filarial diseases including tropical pulmonary eosinophilia, loiasis, and lymphatic filariasis caused by infection with Wuchereria bancrofti, Brugia malayi, or Brugia timori.
Mechanism of action The mechanism of action of diethylcarbamazine is thought to involve sensitizing the microfilariae to phagocytosis. One study showed that diethylcarbamazine's activity against Brugia malayi microfilariae is dependent on inducible nitric-oxide synthase and the cyclooxygenase pathway. It confirmed the important role of the arachidonic acid metabolic pathway in diethylcarbamazine's mechanism of action in vivo and showes that in addition to its effects on the 5-lipoxygenase pathway, it targets the cyclooxygenase pathway and COX-1.
Absorption Readily absorbed following oral administration.
Protein binding Not Available
Biotransformation Partially metabolized to diethylcarbamazine N-oxide.
Route of elimination Not Available
Toxicity Oral LD50 in rat and mouse is 1400 mg/kg and 660 mg/kg, respectively.
Affected organisms
  • Humans and other mammals
  • Parasitic nematodes and other roundworms
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Arachidonate 5-lipoxygenase
Name Arachidonate 5-lipoxygenase
Gene Name ALOX5
Pharmacological action yes
Actions inhibitor
References
  • Bach MK, Brashler JR: Inhibition of the leukotriene synthetase of rat basophil leukemia cells by diethylcarbamazine, and synergism between diethylcarbamazine and piriprost, a 5-lipoxygenase inhibitor. Biochem Pharmacol. 1986 Feb 1;35(3):425-33. - Pubmed
  • Cernak I, Savic J, Malicevic Z, Zunic G, Radosevic P, Ivanovic I: Leukotrienes in the pathogenesis of pulmonary blast injury. J Trauma. 1996 Mar;40(3 Suppl):S148-51. - Pubmed
  • Gross NJ, Holloway NO, Narine KR: Effects of some nonsteroidal anti-inflammatory agents on experimental radiation pneumonitis. Radiat Res. 1991 Sep;127(3):317-24. - Pubmed
  • Zunic G, Cernak I, Malicevic Z, Savic J: Inhibition of leukotriene formation by diethylcarbamazine modifies the acid-base balance in the rabbits with blast injuries of the lungs. Vojnosanit Pregl. 1999 May-Jun;56(3):243-7. - Pubmed
  • Davidson D, Drafta D: Prolonged pulmonary hypertension caused by platelet-activating factor and leukotriene C4 in the rat lung. J Appl Physiol. 1992 Sep;73(3):955-61. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 0.284
Prostaglandin G/H synthase 1
Name Prostaglandin G/H synthase 1
Gene Name PTGS1
Pharmacological action unknown
Actions inhibitor
References
  • McGarry HF, Plant LD, Taylor MJ: Diethylcarbamazine activity against Brugia malayi microfilariae is dependent on inducible nitric-oxide synthase and the cyclooxygenase pathway. Filaria J. 2005 Jun 2;4:4. - Pubmed
DTHybrid score 0.4666

Enzymes


Cholinesterase
Name Cholinesterase
Gene Name BCHE
Actions inhibitor
References
  • Fujimaki Y, Sakamoto M, Shimada M, Kimura E, Aoki Y: Diethylcarbamazine: inhibitory effect on acetylcholinesterase of Dirofilaria immitis and Brugia pahangi. Southeast Asian J Trop Med Public Health. 1989 Jun;20(2):179-82. - Pubmed
DTHybrid score 0.5841

Predictions


Id Partner name Gene Name Score
290 Prostaglandin G/H synthase 2 PTGS2 0.1994
474 Acetylcholinesterase ACHE 0.0937
4757 Cytochrome P450 2C9 CYP2C9 0.0753
4512 Cytochrome P450 3A4 CYP3A4 0.0607
6182 Cytochrome P450 2J2 CYP2J2 0.0472
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0438
4200 Cytochrome P450 1A2 CYP1A2 0.0413
1729 Solute carrier family 22 member 6 SLC22A6 0.0404
1757 Myeloperoxidase MPO 0.0398
4924 Cytochrome P450 2C8 CYP2C8 0.0373
703 NADPH azoreductase azr 0.0352
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0328
1588 Multidrug resistance protein 1 ABCB1 0.0327
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0323
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.032
61 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0304
2644 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0304
2710 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0304
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0303
587 Serum albumin ALB 0.0301
6016 Cytochrome P450 2C19 CYP2C19 0.0298
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0253
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0252
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0246
4119 Cytochrome P450 2D6 CYP2D6 0.0243
766 Beta-2 adrenergic receptor ADRB2 0.0238
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0236
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0235
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0228
2433 Capsid protein P40 UL80 0.0213
3569 Capsid protein P40 BVRF2 0.0213
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0208
1507 Cytochrome c CYCS 0.0195
2049 Gastrin/cholecystokinin type B receptor CCKBR 0.0191
3076 Antigen 85-C fbpC 0.0187
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0182
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0182
6030 Cytochrome P450 2B6 CYP2B6 0.0178
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0172
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.017
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0169
5718 Cytochrome P450 2A6 CYP2A6 0.0162
6142 Solute carrier family 22 member 8 SLC22A8 0.016
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0158
6013 Cytochrome P450 2E1 CYP2E1 0.0152
2796 Parathion hydrolase opd 0.0147
6539 Parathion hydrolase opd 0.0147
1024 Solute carrier family 22 member 11 SLC22A11 0.0147
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0144
3454 Esterase estA 0.0141
4118 Cytochrome P450 3A5 CYP3A5 0.0136
2929 (S)-2-haloacid dehalogenase dhlB 0.0124
2995 (S)-2-haloacid dehalogenase Not Available 0.0124
6106 Cytochrome P450 2C18 CYP2C18 0.0122
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0121
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0121
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0117
1650 Heme carrier protein 1 SLC46A1 0.0116
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0112
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0106
2164 Multidrug resistance-associated protein 4 ABCC4 0.0105
831 D(2) dopamine receptor DRD2 0.0105
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0103
33 Cystine/glutamate transporter SLC7A11 0.0102
244 Angiotensin-converting enzyme ACE 0.0101
1654 Interleukin-1 beta IL1B 0.01
6024 Cytochrome P450 1A1 CYP1A1 0.01
4674 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase cumD 0.0097
556 Alpha-1A adrenergic receptor ADRA1A 0.0096
6143 Solute carrier family 22 member 7 SLC22A7 0.0095
373 Transthyretin TTR 0.0093
183 Vascular endothelial growth factor A VEGFA 0.0092
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.009
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0089
3312 Fatty acid-binding protein, brain FABP7 0.0086
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0084
494 Caspase-1 CASP1 0.0083
6145 Solute carrier family 22 member 1 SLC22A1 0.008
124 Histamine H2 receptor HRH2 0.008
6144 Solute carrier family 22 member 2 SLC22A2 0.0079
4784 Beta-mannosidase manB 0.0078
6695 Beta-mannosidase BT_0458 0.0078
22 30S ribosomal protein S4 rpsD 0.0076
6714 30S ribosomal protein S4 rpsD 0.0076
86 SEC14-like protein 4 SEC14L4 0.0075
4077 Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform PPP2CB 0.0075
375 SEC14-like protein 3 SEC14L3 0.0075
4076 Diacylglycerol kinase alpha DGKA 0.0075
341 5-hydroxytryptamine 3 receptor HTR3A 0.0073
140 30S ribosomal protein S9 rpsI 0.0072
6719 30S ribosomal protein S9 rpsI 0.0072
6725 30S ribosomal protein S9 rpsI 0.0072
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0071
2077 Caspase-3 CASP3 0.0069
3811 Cytochrome P450 19A1 CYP19A1 0.0069
65 Matrix metalloproteinase-9 Not Available 0.0068
2998 Sialic acid-binding Ig-like lectin 7 SIGLEC7 0.0068
638 D(3) dopamine receptor DRD3 0.0068
713 Sodium-dependent dopamine transporter SLC6A3 0.0065
708 Alpha-tocopherol transfer protein TTPA 0.0065
85 Growth hormone receptor GHR 0.0065
283 SEC14-like protein 2 SEC14L2 0.0064
904 Glutathione S-transferase P GSTP1 0.0064
905 Glutathione transferase omega-1 GSTO1 0.0063
899 Glutathione S-transferase Mu 3 GSTM3 0.0063
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0063
3480 Mannan endo-1,4-beta-mannosidase manA 0.0063
146 Androgen receptor AR 0.0062
6107 Cytochrome P450 3A7 CYP3A7 0.0062
4787 Envelope glycoprotein gp160 env 0.0061
4820 Envelope glycoprotein gp160 env 0.0061
5727 Envelope glycoprotein gp160 env 0.0061
4078 Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform PPP2CA 0.0061
997 Protein kinase C beta type PRKCB 0.0059
2297 Genome polyprotein Not Available 0.0058
2322 Genome polyprotein Not Available 0.0058
2694 Genome polyprotein Not Available 0.0058
2719 Genome polyprotein Not Available 0.0058
2860 Genome polyprotein Not Available 0.0058
2928 Genome polyprotein Not Available 0.0058
3160 Genome polyprotein Not Available 0.0058
3260 Genome polyprotein Not Available 0.0058
4783 Genome polyprotein Not Available 0.0058
5726 Genome polyprotein Not Available 0.0058
5779 Genome polyprotein Not Available 0.0058
5867 Genome polyprotein Not Available 0.0058
6253 Genome polyprotein Not Available 0.0058
6301 Genome polyprotein Not Available 0.0058
6380 Genome polyprotein Not Available 0.0058
6381 Genome polyprotein Not Available 0.0058
6437 Genome polyprotein Not Available 0.0058
6520 Genome polyprotein Not Available 0.0058
6521 Genome polyprotein Not Available 0.0058
6652 Genome polyprotein Not Available 0.0058
6734 Genome polyprotein Not Available 0.0058
6735 Genome polyprotein Not Available 0.0058
6736 Genome polyprotein Not Available 0.0058
6737 Genome polyprotein Not Available 0.0058
6738 Genome polyprotein Not Available 0.0058
6739 Genome polyprotein Not Available 0.0058
6744 Genome polyprotein Not Available 0.0058
6748 Genome polyprotein Not Available 0.0058
6894 Genome polyprotein Not Available 0.0058
6898 Genome polyprotein Not Available 0.0058
810 Heme oxygenase 1 HMOX1 0.0058
3391 Heme oxygenase 1 pbsA1 0.0058
186 Glutamate--cysteine ligase catalytic subunit GCLC 0.0057
1970 Protein kinase C alpha type PRKCA 0.0055
465 Calmodulin CALM1 0.0054
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0053
862 Multidrug resistance-associated protein 1 ABCC1 0.0053
850 Vasopressin V1b receptor AVPR1B 0.0053
3947 Xanthine dehydrogenase/oxidase XDH 0.0053
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0052
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0052
3437 Eosinophil lysophospholipase CLC 0.0052
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.005
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.005
131 Synaptic vesicular amine transporter SLC18A2 0.005
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0049
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0049
3932 Glutathione S-transferase A2 GSTA2 0.0049
737 Mineralocorticoid receptor NR3C2 0.0048
70 Type-1 angiotensin II receptor AGTR1 0.0048
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0047
1656 CYP2B protein CYP2B 0.0047
738 Monocarboxylate transporter 1 SLC16A1 0.0046
185 Vasopressin V1a receptor AVPR1A 0.0046
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0046
322 Vasopressin V2 receptor AVPR2 0.0046
6012 Tryptophan 2,3-dioxygenase TDO2 0.0045
6131 Carbonic anhydrase 14 CA14 0.0045
6102 Arylamine N-acetyltransferase 2 NAT2 0.0044
7 Nitric oxide synthase, inducible NOS2 0.0044
318 Alpha-2A adrenergic receptor ADRA2A 0.0044
2981 Phospholipase A2, membrane associated PLA2G2A 0.0044
118 Organic cation/carnitine transporter 2 SLC22A5 0.0044
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0044
614 Progesterone receptor PGR 0.0043
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0043
6147 Solute carrier family 22 member 3 SLC22A3 0.0043
232 Corticosteroid-binding globulin SERPINA6 0.0043
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0042
436 5-hydroxytryptamine 2B receptor HTR2B 0.0042
2207 Rhodopsin RHO 0.0041
468 Cytochrome P450 4A11 CYP4A11 0.0041
811 Translocator protein TSPO 0.004
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.004
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.004
274 Muscarinic acetylcholine receptor M5 CHRM5 0.004
4132 Chloride channel protein ClC-Ka CLCNKA 0.0039
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0039
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0039
2853 14 kDa fatty acid-binding protein Not Available 0.0037
23 D(1A) dopamine receptor DRD1 0.0037
6085 Fatty acid-binding protein, intestinal FABP2 0.0037
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0037
4785 Ig gamma-1 chain C region IGHG1 0.0037
871 Glucocorticoid receptor NR3C1 0.0036
144 Hemoglobin subunit alpha HBA1 0.0036
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0035
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0035
1648 Elastin ELN 0.0035
558 Solute carrier family 12 member 1 SLC12A1 0.0034
1517 Beta-3 adrenergic receptor ADRB3 0.0033
3426 Glutamine synthetase glnA 0.0033
3987 Glutamine synthetase GLUL 0.0033
6043 Putative G-protein coupled receptor 44 GPR44 0.0032
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0032
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0032
833 Organic cation/carnitine transporter 1 SLC22A4 0.0032
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0031
1178 Adenosine A2a receptor ADORA2A 0.0031
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0031
6500 Phospholipase A2 PLA2G1B 0.0031
6103 Arylamine N-acetyltransferase 1 NAT1 0.0028
130 Prostacyclin synthase PTGIS 0.0028
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0027
320 5-hydroxytryptamine 1A receptor HTR1A 0.0027
6146 High affinity copper uptake protein 1 SLC31A1 0.0026
492 Histamine H1 receptor HRH1 0.0026
2183 Fatty acid-binding protein, adipocyte FABP4 0.0026
6137 Multidrug resistance-associated protein 6 ABCC6 0.0026
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0025
427 Substance-P receptor TACR1 0.0025
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0025
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0025
4604 Liver carboxylesterase 1 CES1 0.0024
759 Free fatty acid receptor 1 FFAR1 0.0024
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0024
1818 Long-chain-fatty-acid--CoA ligase 3 ACSL3 0.0024
106 Cannabinoid receptor 2 CNR2 0.0024
6033 High affinity interleukin-8 receptor A CXCR1 0.0024
1629 Transcription factor AP-1 JUN 0.0024
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0023
489 Monocarboxylate transporter 2 SLC16A7 0.0023
68 Cannabinoid receptor 1 CNR1 0.0023
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0023
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0023
723 Cytosolic phospholipase A2 PLA2G4A 0.0023
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0023
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0023
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0023
634 Squalene monooxygenase SQLE 0.0022
7196 Squalene monooxygenase ERG1 0.0022
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0022
1714 Mitogen-activated protein kinase 3 MAPK3 0.0022
908 Glutathione S-transferase theta-1 GSTT1 0.0022
4943 Cytochrome c6 petJ 0.0022
4934 Cytochrome c-551 nirM 0.0022
5218 Cytochrome c-551 nirM 0.0022
4905 Cytochrome c2 Not Available 0.0022
4939 Cytochrome c2 cycA 0.0022
4964 Cytochrome c2 cycA 0.0022
4979 Cytochrome c2 cycA 0.0022
6673 Cytochrome c2 cycA 0.0022
4947 Bacterial hemoglobin vhb 0.0022
4916 Cyanoglobin glbN 0.0022
4994 Hemoglobin-like protein HbO glbO 0.0022
4975 Cytochrome c-556 RPA3973 0.0022
4942 Diheme cytochrome c napB napB 0.0022
4909 CooA protein cooA 0.0022
4954 Soluble cytochrome b558 Not Available 0.0022
3116 Bacterioferritin bfr 0.0022
4906 Bacterioferritin bfr 0.0022
4965 Bacterioferritin bfr 0.0022
4981 Iron-starvation protein PigA pigA 0.0022
4915 Cytochrome c-550 psbV 0.0022
4959 Cytochrome c-550 psbV 0.0022
5216 Cytochrome c-550 psbV 0.0022
4925 Cytochrome c-type protein SHP shp 0.0022
4907 Cytochrome c-L moxG 0.0022
6865 Cytochrome c-L moxG 0.0022
4936 Cytochrome c2 iso-2 Not Available 0.0022
4989 Cytochrome c551 peroxidase ccp 0.0022
5222 Cytochrome c551 peroxidase ccpA 0.0022
4998 Hemoglobin-like protein yjbI yjbI 0.0022
4984 Neuroglobin NGB 0.0022
5000 HemO hemO 0.0022
644 Heme oxygenase 2 HMOX2 0.0022
4982 Heme oxygenase 2 pbsA2 0.0022
4935 Cytochrome c-554 cycA1 0.0022
4999 Cytochrome P450 165B3 CYP165B3 0.0022
4764 Cytochrome P450 165C4 CYP165C4 0.0022
4961 Hemophore HasA hasA 0.0022
4976 Apocytochrome f petA 0.0022
6407 Apocytochrome f petA 0.0022
4937 Cytochrome oxidase subunit II rcoxA 0.0022
4971 Nonaheme cytochrome c hmcA 0.0022
4910 Cytoglobin CYGB 0.0022
4904 Cytochrome c family protein GSU1996 0.0022
4926 Heme-based aerotactic transducer hemAT hemAT 0.0022
4931 Cytochrome P450 167A1 CYP167A1 0.0022
4972 P450cin cinA 0.0022
4960 Putative cytochrome P450-family protein SCO7417 0.0022
4903 Methyl-accepting chemotaxis protein Tar4 0.0022
4952 Catalase/peroxidase katA 0.0022
4922 Cytochrome c, putative SO_4144 0.0022
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0022
4993 Hydroxylamine oxidoreductase hao1 0.0022
3093 Catalase HPII katE 0.0022
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0022
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0021
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0021
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0021
4608 Putative cytochrome P450 SCO1207 0.0021
4963 Putative cytochrome P450 SCO2884 0.0021
6254 Putative cytochrome P450 SCO6998 0.0021
1053 BC269730_2 FADS1 0.0021
1395 Sodium/calcium exchanger 1 SLC8A1 0.0021
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0021
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0021
823 Fibroblast growth factor receptor 2 FGFR2 0.002
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.002
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.002
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.002
1558 Transient receptor potential cation channel subfamily V member 1 TRPV1 0.002
102 DNA topoisomerase I, mitochondrial TOP1MT 0.002
6014 Cytochrome P450 2A13 CYP2A13 0.002
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0019
3601 Dihydropteroate synthase 1 folP1 0.0019
3807 Dihydropteroate synthase 1 folP1 0.0019
3808 Dihydropteroate synthase 2 folP2 0.0019
260 Cytochrome P450 51 ERG11 0.0019
761 Cytochrome P450 51 ERG11 0.0019
3163 Cytochrome P450 51 cyp51 0.0019
777 Tumor necrosis factor TNF 0.0019
891 Dihydropteroate synthase folP 0.0018
5359 Dihydropteroate synthase folP 0.0018
7175 Dihydropteroate synthase sulI 0.0018
2236 Casein kinase II subunit alpha CSNK2A1 0.0018
459 Retinoic acid receptor RXR-alpha RXRA 0.0018
6149 Solute carrier family 22 member 10 SLC22A10 0.0018
467 Delta-type opioid receptor OPRD1 0.0018
696 Kappa-type opioid receptor OPRK1 0.0017
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0017
3929 Phosphoethanolamine/phosphocholine phosphatase PHOSPHO1 0.0017
549 Choline-phosphate cytidylyltransferase B PCYT1B 0.0017
264 Choline/ethanolamine kinase [Includes: Choline kinase beta CHKB 0.0017
3927 Choline transporter-like protein 3 SLC44A3 0.0017
861 Choline kinase alpha CHKA 0.0017
3933 Choline/ethanolaminephosphotransferase CEPT1 0.0017
769 High-affinity choline transporter 1 SLC5A7 0.0017
700 Choline dehydrogenase, mitochondrial CHDH 0.0017
1686 Choline transporter-like protein 1 SLC44A1 0.0017
3926 Choline transporter-like protein 2 SLC44A2 0.0017
3925 Choline transporter-like protein 4 SLC44A4 0.0017
576 Choline O-acetyltransferase CHAT 0.0017
3922 Phospholipase D2 PLD2 0.0017
3924 Phospholipase D1 PLD1 0.0017
1353 DNA topoisomerase 1 TOP1 0.0017
3552 DNA topoisomerase 1 topA 0.0017
847 Mu-type opioid receptor OPRM1 0.0017
502 5-hydroxytryptamine 2A receptor HTR2A 0.0016
4920 Peroxidase/catalase katG 0.0016
4103 Proteasome subunit beta type 2 PSMB2 0.0016
4102 Proteasome subunit beta type 5 PSMB5 0.0016
4101 Proteasome subunit beta type 1 PSMB1 0.0016
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0016
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0016
4037 Hypothetical protein GPX1 0.0016
4297 Hypothetical protein SP_1951 0.0016
4521 Hypothetical protein BC_2969 0.0016
4540 Hypothetical protein TM_1070 0.0016
4555 Hypothetical protein MT1739 0.0016
4569 Hypothetical protein mshD 0.0016
4578 Hypothetical protein PA3270 0.0016
4747 Hypothetical protein PA3967 0.0016
5177 Hypothetical protein TM_0096 0.0016
5194 Hypothetical protein PA1204 0.0016
5240 Hypothetical protein Rv2991 0.0016
5370 Hypothetical protein TM_1158 0.0016
5710 Hypothetical protein Tb927.5.1360 0.0016
2119 Cytochrome b5 CYB5A 0.0016
4948 Cytochrome c-553 Not Available 0.0016
4990 PpcA ppcA 0.0016
4923 Cytochrome c3 DvMF_2499 0.0016
4945 Cytochrome c3 Not Available 0.0016
4949 Cytochrome c3 DVU_3171 0.0016
4968 Cytochrome c3 cytc3 0.0016
4997 Cytochrome c3 SO_2727 0.0016
5219 Cytochrome c3 cyd 0.0016
4902 Nine-heme cytochrome c Ddes_2038 0.0016
3189 High-molecular-weight cytochrome c hmcA 0.0016
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0016
4289 Cytochrome P450 TT_P0059 0.0016
6262 Cytochrome P450 staP 0.0016
3570 Cytochrome P450 152A1 cypC 0.0016
4992 Cytochrome c peroxidase Not Available 0.0016
4988 Sulfite oxidase, mitochondrial SUOX 0.0016
2915 Sensor protein fixL fixL 0.0016
4944 Sensor protein fixL fixL 0.0016
4385 Cytochrome c' Not Available 0.0016
4967 Cytochrome c' cycA 0.0016
5038 Cytochrome c' Not Available 0.0016
5223 Cytochrome c' cycP 0.0016
3375 Acidic cytochrome c3 Not Available 0.0016
4813 Heme oxygenase hmuO 0.0016
5769 Heme oxygenase Not Available 0.0016
822 Aldose reductase AKR1B1 0.0016
2230 Catalase CAT 0.0015
3249 Catalase katA 0.0015
3625 Catalase katA 0.0015
4539 Catalase katA 0.0015
4941 Catalase katB 0.0015
4878 Glycoprotein hormones alpha chain CGA 0.0015
1052 Cytotoxic T-lymphocyte protein 4 CTLA4 0.0015
1072 Granzyme B GZMB 0.0015
4871 Endo-beta-N-acetylglucosaminidase F3 endOF3 0.0015
4889 Ig epsilon chain C region IGHE 0.0015
4877 Beta-mannanase man 0.0015
4880 Membrane cofactor protein CD46 0.0015
4850 Beta-2-glycoprotein 1 APOH 0.0015
4189 Alpha-galactosidase A GLA 0.0015
4856 CD209 antigen CD209 0.0015
4869 Major capsid protein A430L 0.0015
1563 Platelet glycoprotein Ib alpha chain GP1BA 0.0015
757 Fusion glycoprotein F0 F 0.0015
4875 Fusion glycoprotein F0 F 0.0015
1354 Beta-glucuronidase GUSB 0.0015
4852 Reticulon-4 receptor RTN4R 0.0015
4845 ADAM 33 ADAM33 0.0015
442 Envelope glycoprotein gp41 0.0015
4859 Envelope glycoprotein env 0.0015
4882 Dipeptidyl aminopeptidase-like protein 6 DPP6 0.0015
4721 Beta-1,4-mannanase manA 0.0015
3352 Structural polyprotein Not Available 0.0015
3628 Structural polyprotein Not Available 0.0015
4892 Structural polyprotein Not Available 0.0015
1374 Natriuretic peptides B NPPB 0.0015
1898 Cytochrome P450 1B1 CYP1B1 0.0015
1827 Gap junction alpha-1 protein GJA1 0.0015
1908 Vascular cell adhesion protein 1 VCAM1 0.0015
1184 Interferon beta IFNB1 0.0015
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0015
511 5-hydroxytryptamine 1F receptor HTR1F 0.0015
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0014
76 Nitric-oxide synthase, brain NOS1 0.0014
3670 Soluble cytochrome b562 precursor cybC 0.0014
3411 Cytochrome P450 121 cyp121 0.0014
528 5-hydroxytryptamine 1E receptor HTR1E 0.0014
2617 Nitric oxide synthase oxygenase nos 0.0014
2701 Nitric oxide synthase oxygenase nos 0.0014
3291 Cytochrome c-552 cycA 0.0014
4927 Cytochrome c-552 nrfA 0.0014
4938 Cytochrome c-552 cycA 0.0014
4953 Cytochrome c-552 nrfA 0.0014
5217 Cytochrome c-552 cycM 0.0014
4386 Hemoglobin-like protein HbN glbN 0.0014
3102 Flavohemoprotein hmp 0.0014
4969 Flavohemoprotein hmp 0.0014
518 Peroxidase/catalase T katG 0.0013
4861 Interleukin-6 receptor alpha chain IL6R 0.0013
793 T-cell surface antigen CD2 CD2 0.0013
4193 Atrial natriuretic peptide clearance receptor NPR3 0.0013
119 Carcinoembryonic antigen-related cell adhesion molecule 1 CEACAM1 0.0013
3837 Cytokine receptor common beta chain CSF2RB 0.0013
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0013
6163 Copper-transporting ATPase 2 ATP7B 0.0013
6165 Copper-transporting ATPase 1 ATP7A 0.0013
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0012
4498 Ornithine cyclodeaminase PP3533 0.0012
605 Fumarate reductase flavoprotein subunit frdA 0.0012
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0012
3673 Fumarate reductase flavoprotein subunit fccA 0.0012
4912 Fumarate reductase flavoprotein subunit ifcA 0.0012
6549 Fumarate reductase flavoprotein subunit frdA 0.0012
2021 Thrombomodulin THBD 0.0012
3127 Nitrite reductase nirS 0.0012
3284 Nitrite reductase nirS 0.0012
2972 6-deoxyerythronolide B hydroxylase eryF 0.0012
3221 Cytochrome c4 cc4 0.0012
4666 Fucose-binding lectin PA-IIL lecB 0.0012
2372 Bifunctional tail protein 9 0.0012
716 5-hydroxytryptamine 7 receptor HTR7 0.0012
776 Bile salt export pump ABCB11 0.0012
5449 Hypothetical gliding protein mglB 0.0012
5443 UPF0189 protein ymdB ymdB 0.0012
5440 UPF0067 protein yebR yebR 0.0012
4705 Manganese catalase Not Available 0.0012
5439 33 kDa chaperonin hslO 0.0012
5446 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase HI_1679 0.0012
2720 Copper-containing nitrite reductase nirK 0.0012
5448 Ribonuclease Z rnz 0.0012
3781 Thiol:disulfide interchange protein dsbC precursor dsbC 0.0012
5447 Lethal(3)malignant brain tumor-like protein L3MBTL1 0.0012
5454 Internalin-A inlA 0.0012
332 Beta-lactamase blaZ 0.0012
2478 Beta-lactamase ampC 0.0012
2613 Beta-lactamase ampC 0.0012
2635 Beta-lactamase ampC 0.0012
2700 Beta-lactamase penP 0.0012
5445 Beta-lactamase blaB 0.0012
6019 Beta-lactamase SHV-7 0.0012
6701 Beta-lactamase cphA 0.0012
1192 Sulfotransferase 1A1 SULT1A1 0.0012
4890 Hemagglutinin HA 0.0012
6566 Hemagglutinin Not Available 0.0012
1379 Interleukin-12 subunit beta IL12B 0.0012
632 Alpha-1B adrenergic receptor ADRA1B 0.0012
4857 Zinc-alpha-2-glycoprotein AZGP1 0.0012
6858 Inactive carboxylesterase 4 CES1P1 0.0012
1864 RET proto-oncogene RET 0.0011
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0011
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0011
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0011
1275 Estrogen sulfotransferase SULT1E1 0.0011
358 Cystathionine beta-synthase CBS 0.0011
6120 Cation-independent mannose-6-phosphate receptor IGF2R 0.0011
18 High affinity immunoglobulin epsilon receptor subunit alpha FCER1A 0.0011
1050 Bile salt sulfotransferase SULT2A1 0.0011
554 Low-density lipoprotein receptor LDLR 0.0011
852 Heparin cofactor 2 SERPIND1 0.0011
896 Glutathione S-transferase Mu 1 GSTM1 0.0011
3736 Glyceraldehyde-3-phosphate dehydrogenase A gapA 0.0011
4192 DNA topoisomerase 2-beta TOP2B 0.0011
5450 Prolyl endopeptidase Pep pep 0.0011
693 Hemoglobin subunit beta HBB 0.001
725 5-hydroxytryptamine 1D receptor HTR1D 0.001
3356 Diaminopimelate decarboxylase lysA 0.001
597 Dihydropteridine reductase QDPR 0.001
4771 Dissimilatory copper-containing nitrite reductase nir 0.001
885 5-hydroxytryptamine 1B receptor HTR1B 0.001
3274 Hydroxylamine reductase hcp 0.001
4804 Hydroxylamine reductase hcp 0.001
1039 Histone deacetylase 9 HDAC9 0.001
2714 Chorismate mutase aroH 0.001
4611 Chorismate mutase aroG 0.001
1859 Prostatic acid phosphatase ACPP 0.001
595 Fibrinogen alpha chain FGA 0.001
3444 Cyanovirin-N Not Available 0.001
3140 Hemagglutinin-neuraminidase HN 0.001
3609 Hemagglutinin-neuraminidase HN 0.001
3258 Mannosyl-oligosaccharide alpha-1,2-mannosidase MSDC 0.001
6268 Hydroxyacid oxidase 1 HAO1 0.001
2430 Chondroitinase B cslB 0.001
3462 Tyrosine-protein kinase transforming protein Abl ABL 0.001
1618 High affinity nerve growth factor receptor NTRK1 0.001
6136 Multidrug resistance-associated protein 5 ABCC5 0.001
3399 Limonene-1,2-epoxide hydrolase limA 0.001
3697 Bifunctional protein glmU [Includes: UDP-N-acetylglucosamine pyrophosphorylase glmU 0.001
6042 Prostaglandin reductase 2 PTGR2 0.0009
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0009
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0009
5180 L(+)-mandelate dehydrogenase mdlB 0.0009
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0009
577 Argininosuccinate lyase ASL 0.0009
3500 Putative family 31 glucosidase yicI yicI 0.0009
958 Insulin-like growth factor 1 receptor IGF1R 0.0009
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0009
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0009
1615 Chymase CMA1 0.0009
1792 Tissue-type plasminogen activator PLAT 0.0009
921 Glutamate receptor 2 GRIA2 0.0009
2298 Cytochrome P450-cam camC 0.0009
228 Beta platelet-derived growth factor receptor PDGFRB 0.0009
2577 Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase MAN1B1 0.0009
3814 Complement C1r subcomponent C1R 0.0009
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0009
64 Neuraminidase NA 0.0008
641 Neuraminidase NA 0.0008
2676 Neuraminidase NA 0.0008
3026 Neuraminidase NA 0.0008
3519 Neuraminidase NA 0.0008
6007 Neuraminidase NA 0.0008
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0008
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0008
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0008
1243 Cathepsin D CTSD 0.0008
273 Apoptosis regulator Bcl-2 BCL2 0.0008
6148 Multidrug resistance-associated protein 7 ABCC10 0.0008
2597 Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] glmS 0.0008
365 Dihydrofolate reductase DHFR 0.0008
2381 Dihydrofolate reductase DFR1 0.0008
2833 Dihydrofolate reductase Not Available 0.0008
2931 Dihydrofolate reductase folA 0.0008
3544 Dihydrofolate reductase folA 0.0008
3682 Dihydrofolate reductase folA 0.0008
6642 Dihydrofolate reductase folA 0.0008
6756 Dihydrofolate reductase dfrA 0.0008
287 Beta-1,4-galactosyltransferase 1 B4GALT1 0.0008
1439 Lactotransferrin LTF 0.0008
504 Mast/stem cell growth factor receptor KIT 0.0008
1782 Neutrophil gelatinase-associated lipocalin LCN2 0.0008
309 Antithrombin-III SERPINC1 0.0008
817 DNA topoisomerase 2-alpha TOP2A 0.0008
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0008
193 Beta-1 adrenergic receptor ADRB1 0.0008
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0007
6307 Ig gamma-2 chain C region IGHG2 0.0007
1313 Lactoylglutathione lyase GLO1 0.0007
2581 Chondroitinase AC cslA 0.0007
6847 Lactase-phlorizin hydrolase LCT 0.0007
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0007
291 Nitric-oxide synthase, endothelial NOS3 0.0007
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0007
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0007
789 Alpha-1D adrenergic receptor ADRA1D 0.0007
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0007
824 Sodium-dependent serotonin transporter SLC6A4 0.0006
6141 Sodium/bile acid cotransporter SLC10A1 0.0006
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0005
952 Dipeptidyl peptidase 4 DPP4 0.0005
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0005
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0005
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0005
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0005
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0005
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0005
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0005
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0005
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0005
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0005
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0005
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0005
4509 Acetoin(diacetyl) reductase budC 0.0004
3689 Endoglucanase A celA 0.0004
3009 Beta-glucanase Not Available 0.0004
5411 Slt-IIvB stxB2e 0.0004
5565 Inorganic polyphosphate/ATP-glucomannokinase ppgmk 0.0004
5563 Galectin-2 LGALS2 0.0004
1875 Pulmonary surfactant-associated protein D SFTPD 0.0004
5569 Endo-1,4-beta glucanase EngF engF 0.0004
5046 Ecotin eco 0.0004
3793 Aspartate ammonia-lyase aspA 0.0004
5554 D-galactose-binding periplasmic protein mglB 0.0004
3741 D-galactose-binding periplasmic protein precursor mglB 0.0004
5568 Endoglucanase C307 celC307 0.0004
5553 Endoglucanase E1 Acel_0614 0.0004
5562 Hexokinase Not Available 0.0004
3744 Endoglucanase SS precursor celS 0.0004
5570 Endoglucanase E-4 celD 0.0004
5559 Neopullulanase nplT 0.0004
4670 Cellulase B celB 0.0004
4668 Laminarinase TM_0024 0.0004
4667 BH0236 protein BH0236 0.0004
4671 Endoglucanase C cenC 0.0004
5176 YtnJ moxC 0.0003
5416 Coat protein VP1 Not Available 0.0003
2705 Dimethyl sulfoxide reductase dmsA 0.0003
5247 Endo-1,4-beta-xylanase Not Available 0.0003
5248 Endo-1,4-beta-xylanase xlnA 0.0003
5250 Endo-1,4-beta-xylanase xyl 0.0003
4669 Endo-1,4-beta-xylanase A xynA 0.0003
4715 Endo-1,4-beta-xylanase A xlnA 0.0003
5560 Endo-1,4-beta-xylanase A xynA 0.0003
1503 Galectin-7 LGALS7 0.0003
5498 Maltoporin lamB 0.0003
5561 Maltoporin lamB 0.0003
5056 Maltooligosyltrehalose trehalohydrolase, putative treZ 0.0003
3525 ADP-ribose pyrophosphatase, mitochondrial NUDT9 0.0003
4622 Amylase Not Available 0.0003
2728 Glucan 1,4-alpha-maltotetraohydrolase amyP 0.0003
2826 Glucose--fructose oxidoreductase gfo 0.0003
1881 Hexokinase-1 HK1 0.0003
2324 Botulinum neurotoxin type B botB 0.0003
3153 Quinoprotein glucose dehydrogenase-B gdhB 0.0003
3747 Cellulase B precursor celB 0.0003
3547 Enterotoxin type B entB 0.0003
2856 Glucosamine-6-phosphate isomerase GNPDA1 0.0003
2564 Glucan 1,4-alpha-maltohexaosidase Not Available 0.0003
4819 Hydrolase Not Available 0.0003
5249 Hydrolase Not Available 0.0003
5436 Hydrolase Not Available 0.0003
2531 Alpha-amylase amyE 0.0003
2948 Alpha-amylase amy 0.0003
3169 Alpha-amylase Not Available 0.0003
2541 Neopullulanase 1 tvaI 0.0003
4811 Amylosucrase ams 0.0003
3091 Maltodextrin phosphorylase malP 0.0003
2606 Neopullulanase 2 tvaII 0.0003
4692 A/G-specific adenine glycosylase mutY 0.0003
3225 Shiga toxin B-chain stxB 0.0003
3365 Beta-amylase spoII 0.0003
4830 Aldose 1-epimerase galM 0.0003
6614 Lactase-like protein LCTL 0.0003
1675 Glucokinase GCK 0.0003
4662 Glucokinase glk 0.0003
3030 Salivary alpha-amylase AMY1A 0.0003
2293 Cyclomaltodextrin glucanotransferase Not Available 0.0003
2508 Cyclomaltodextrin glucanotransferase cgt 0.0003
2523 Cyclomaltodextrin glucanotransferase cgt 0.0003
3207 Cyclomaltodextrin glucanotransferase amyA 0.0003
4272 POSSIBLE CELLULASE CELA1 celA1 0.0003
2570 Tetanus toxin tetX 0.0002
2448 Exoglucanase/xylanase [Includes: Exoglucanase cex 0.0002
3668 Maltose-binding periplasmic protein precursor malE 0.0002
2802 Endoglucanase G celCCG 0.0002
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0002
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0002
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0002
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0002
2440 Endoglucanase F celCCF 0.0002
2245 Xylose isomerase xylA 0.0002
2253 Xylose isomerase xylA 0.0002
2260 Xylose isomerase xylA 0.0002
2431 Xylose isomerase xylA 0.0002
2252 Endoglucanase 5A cel5A 0.0002
10 Glycogen phosphorylase, liver form PYGL 0.0002
2723 Cholera enterotoxin subunit B ctxB 0.0002
4513 Pancreatic alpha-amylase AMY2A 0.0002
2427 Ferrichrome-iron receptor fhuA 0.0002
1152 Glycogen phosphorylase, muscle form PYGM 0.0002
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