DT-Web

DB02726 - 2-Phosphoglycolic Acid


Identification
Name 2-Phosphoglycolic Acid
Accession Number DB02726 (DB02389, EXPT02567)
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 156.0313
Groups experimental
Monoisotopic Weight 155.982374404
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Glucosamine-6-phosphate deaminase 1
Name Glucosamine-6-phosphate deaminase 1
Gene Name nagB
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.8367
6-phosphofructokinase
Name 6-phosphofructokinase
Gene Name pfkA
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.0363
Triosephosphate isomerase
Name Triosephosphate isomerase
Gene Name TPI1
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.5139
Pyruvate kinase isozymes M1/M2
Name Pyruvate kinase isozymes M1/M2
Gene Name PKM2
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.8906
Triosephosphate isomerase
Name Triosephosphate isomerase
Gene Name tpiA
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.5139
Methylglyoxal synthase
Name Methylglyoxal synthase
Gene Name mgsA
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.9253
Gamma-enolase
Name Gamma-enolase
Gene Name ENO2
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score Not Available
Triosephosphate isomerase
Name Triosephosphate isomerase
Gene Name tpiA
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.5139
Phospho-2-dehydro-3-deoxyheptonate aldolase, Phe-sensitive
Name Phospho-2-dehydro-3-deoxyheptonate aldolase, Phe-sensitive
Gene Name aroG
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.9798
Pyruvate kinase isozymes R/L
Name Pyruvate kinase isozymes R/L
Gene Name PKLR
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.9315
Triosephosphate isomerase
Name Triosephosphate isomerase
Gene Name TPI
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.5139
Phosphatase yniC
Name Phosphatase yniC
Gene Name yniC
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.9734
Beta-enolase
Name Beta-enolase
Gene Name ENO3
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score Not Available

Predictions


Id Partner name Gene Name Score
2262 2,3-bisphosphoglycerate-independent phosphoglycerate mutase gpmI 0.257
1750 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 PFKFB1 0.2399
3705 L-fuculose phosphate aldolase fucA 0.2043
3000 N-acetylneuraminate lyase nanA 0.2031
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.203
2310 2-dehydro-3-deoxyphosphooctonate aldolase kdsA 0.1816
2542 2-dehydro-3-deoxyphosphooctonate aldolase kdsA 0.1816
2922 Glycerol kinase glpK 0.1719
6433 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 PFKFB4 0.1703
2926 Bifunctional PGK/TIM [Includes: Phosphoglycerate kinase pgk/tpi 0.1605
3727 Tagatose-1,6-bisphosphate aldolase agaY kbaY 0.1571
3693 Fructose-bisphosphate aldolase class 2 fbaA 0.1569
3419 Rhamnulose-1-phosphate aldolase rhaD 0.1569
2206 Glucose-6-phosphate isomerase GPI 0.129
4198 Fructose-1,6-bisphosphatase 1 FBP1 0.1222
3134 Phospho-2-dehydro-3-deoxyheptonate aldolase aroF 0.1217
4384 Capsule biosynthesis protein synC 0.1122
2803 Pyridoxine 5'-phosphate synthase pdxJ 0.1088
1116 Phosphoenolpyruvate carboxykinase, cytosolic [GTP] PCK1 0.1059
2914 Triosephosphate isomerase, glycosomal Not Available 0.103
3069 Fructose-bisphosphate aldolase A ALDOA 0.059
896 Glutathione S-transferase Mu 1 GSTM1 0.0565
429 Monocarboxylate transporter 6 SLC16A5 0.0505
218 Monocarboxylate transporter 5 SLC16A4 0.0505
397 Monocarboxylate transporter 3 SLC16A8 0.0505
195 Monocarboxylate transporter 7 SLC16A6 0.0505
500 Monocarboxylate transporter 4 SLC16A3 0.0454
771 Pyruvate carboxylase, mitochondrial PC 0.0417
110 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial PDHB 0.041
489 Monocarboxylate transporter 2 SLC16A7 0.0368
114 Alanine--glyoxylate aminotransferase 2, mitochondrial AGXT2 0.0355
2392 Biphenyl-2,3-diol 1,2-dioxygenase bphC 0.0326
3032 Biphenyl-2,3-diol 1,2-dioxygenase bphC 0.0326
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0317
199 Monocarboxylate transporter 8 SLC16A2 0.0313
5682 Ribonuclease pancreatic RNASE1 0.0306
738 Monocarboxylate transporter 1 SLC16A1 0.0282
2795 Methionine aminopeptidase 2 METAP2 0.0262
6151 Monocarboxylate transporter 10 SLC16A10 0.0246
465 Calmodulin CALM1 0.0187
4037 Hypothetical protein GPX1 0.0145
4297 Hypothetical protein SP_1951 0.0145
4521 Hypothetical protein BC_2969 0.0145
4540 Hypothetical protein TM_1070 0.0145
4555 Hypothetical protein MT1739 0.0145
4569 Hypothetical protein mshD 0.0145
4578 Hypothetical protein PA3270 0.0145
4747 Hypothetical protein PA3967 0.0145
5177 Hypothetical protein TM_0096 0.0145
5194 Hypothetical protein PA1204 0.0145
5240 Hypothetical protein Rv2991 0.0145
5370 Hypothetical protein TM_1158 0.0145
5710 Hypothetical protein Tb927.5.1360 0.0145
4106 Guanylate kinase GUK1 0.0145
4516 Guanylate kinase gmk 0.0145
4527 Putative hydrolase ycdX ycdX 0.0145
4536 Transcriptional regulator, IclR family TM_0065 0.0145
4545 Molybdopterin-converting factor subunit 2 moaE 0.0145
4514 Citrate lyase beta subunit-like protein citE 0.0145
4781 Citrate lyase beta subunit-like protein DR_1240 0.0145
2501 Protein ygbM ygbM 0.0145
4547 Iron binding protein FbpA fbpA 0.0145
4529 Oxalate decarboxylase oxdC oxdC 0.0144
4546 Aminotransferase, putative TM_1131 0.0144
4526 Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein TM_1223 0.0144
4524 Mannose-6-phosphate isomerase yvyI 0.0144
4535 Glutaconyl-CoA decarboxylase subunit alpha gcdA 0.0144
4522 Arginine N-succinyltransferase subunit alpha astA 0.0144
4538 Hypothetical protein VC1899 VC_1899 0.0144
658 Para-aminobenzoate synthase component 1 pabB 0.0144
4548 Gyrase B gyrB 0.0144
4515 Peripheral plasma membrane protein CASK CASK 0.0144
2929 (S)-2-haloacid dehalogenase dhlB 0.0126
2995 (S)-2-haloacid dehalogenase Not Available 0.0126
4528 Phenazine biosynthesis protein PhzD phzD1 0.0126
4533 Glyoxalase family protein BC_1747 0.0126
56 Delta-aminolevulinic acid dehydratase ALAD 0.0126
2356 Delta-aminolevulinic acid dehydratase hemB 0.0126
3613 Delta-aminolevulinic acid dehydratase hemB 0.0126
3674 Delta-aminolevulinic acid dehydratase hemB 0.0126
3759 Glutathione S-transferase gst 0.0126
4541 Glutathione S-transferase GST 0.0126
3261 Signal recognition particle protein ffh 0.0126
4496 C-terminal-binding protein 1 CTBP1 0.0126
3237 Beta-lactamase OXA-2 bla 0.0126
4542 Glutaminase 1 glsA1 0.0126
4544 Glutaminase 1 glsA1 0.0126
4517 Probable butyrate kinase 2 buk2 0.0126
4532 Gephyrin GPHN 0.0126
4531 Putative ketoacyl reductase actIII 0.0116
3583 6-phosphogluconolactonase pgl 0.0116
2775 Dihydroorotate dehydrogenase pyrD 0.0116
2230 Catalase CAT 0.0116
3249 Catalase katA 0.0116
3625 Catalase katA 0.0116
4539 Catalase katA 0.0116
4941 Catalase katB 0.0116
2525 3-phosphoshikimate 1-carboxyvinyltransferase aroA 0.0109
3201 3-phosphoshikimate 1-carboxyvinyltransferase aroA 0.0109
5670 Organic hydroperoxide resistance protein ohr 0.0106
5669 50S ribosomal protein L27 rpmA 0.0106
5675 Chaperone protein torD torD 0.0106
5672 Molybdenum cofactor biosynthesis protein A moaA 0.0106
5410 Unsaturated glucuronyl hydrolase ugl 0.0106
5676 Axin-1 AXIN1 0.0106
5673 C protein alpha-antigen bca 0.0106
2688 Peptide deformylase def 0.0105
2708 Peptide deformylase def 0.0105
3004 Peptide deformylase def 0.0105
4337 Peptide deformylase def 0.0105
4338 Peptide deformylase def 0.0105
5368 Peptide deformylase def 0.0105
5371 Peptide deformylase def 0.0105
6375 Peptide deformylase def 0.0105
6378 Peptide deformylase def 0.0105
6379 Peptide deformylase def 0.0105
6776 Peptide deformylase def 0.0105
6900 Peptide deformylase def 0.0105
4534 Cytohesin-2 CYTH2 0.0105
2548 Subtilisin Carlsberg apr 0.0101
4269 Hypoxanthine-guanine phosphoribosyltransferase, putative HGPRTase 0.01
3317 Holo-[acyl-carrier-protein] synthase acpS 0.0092
4381 Holo-[acyl-carrier-protein] synthase acpS 0.0092
2636 Shikimate dehydrogenase aroE 0.0092
3515 Shikimate dehydrogenase aroE 0.0092
3125 Protease synthase and sporulation negative regulatory protein PAI 1 paiA 0.0092
5599 3-carboxy-cis,cis-muconate cycloisomerase pcaB 0.0092
2280 Listeriolysin regulatory protein prfA 0.0085
6579 Calcium/calmodulin-dependent protein kinase type II alpha chain CAMK2A 0.0085
4811 Amylosucrase ams 0.0085
760 Fibroblast growth factor 1 FGF1 0.0085
3027 Streptavidin Not Available 0.0084
810 Heme oxygenase 1 HMOX1 0.0084
3391 Heme oxygenase 1 pbsA1 0.0084
3191 Histidinol dehydrogenase hisD 0.008
191 Peptide methionine sulfoxide reductase MSRA 0.0076
4084 Peptidyl-prolyl cis-trans isomerase B PPIB 0.0075
909 Maleylacetoacetate isomerase GSTZ1 0.0075
76 Nitric-oxide synthase, brain NOS1 0.0073
611 Retinal dehydrogenase 1 ALDH1A1 0.0058
24 Thymidylate synthase TMP1 0.0057
359 Thymidylate synthase TYMS 0.0057
2626 Thymidylate synthase thyA 0.0057
2729 Thymidylate synthase thyA 0.0057
5352 Thymidylate synthase THYA 0.0057
357 Carbonic anhydrase 2 CA2 0.0053
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0049
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0049
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