DT-Web

DB04132 - S-Hexylglutathione


Identification
Name S-Hexylglutathione
Accession Number DB04132 (EXPT01664)
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 392.491
Groups experimental
Monoisotopic Weight 392.185531397
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Lactoylglutathione lyase
Name Lactoylglutathione lyase
Gene Name GLO1
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.178
Glutathione S-transferase Mu 4
Name Glutathione S-transferase Mu 4
Gene Name GSTM4
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.2123
Glutathione S-transferase P
Name Glutathione S-transferase P
Gene Name GSTP1
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.8226
Glutathione S-transferase
Name Glutathione S-transferase
Gene Name GST
Pharmacological action unknown
Actions Not Available
References Not Available
DTHybrid score 0.1997
Glutathione S-transferase A1
Name Glutathione S-transferase A1
Gene Name GSTA1
Pharmacological action unknown
Actions Not Available
References Not Available
DTHybrid score 0.9584
Glutathione S-transferase theta-2
Name Glutathione S-transferase theta-2
Gene Name GSTT2
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score Not Available

Enzymes


Glutathione S-transferase A1
Name Glutathione S-transferase A1
Gene Name GSTA1
Actions Not Available
References Not Available
DTHybrid score 0.9584

Predictions


Id Partner name Gene Name Score
3759 Glutathione S-transferase gst 0.1997
896 Glutathione S-transferase Mu 1 GSTM1 0.117
5360 High-affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A 0.1126
2300 Lysozyme E 0.0819
3633 Lysozyme R 0.0819
5597 Lysozyme 17 0.0819
3932 Glutathione S-transferase A2 GSTA2 0.0798
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0638
4041 Microsomal glutathione S-transferase 2 MGST2 0.0617
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0476
5898 Complement C3 C3 0.0453
2409 Acetyl-CoA acetyltransferase, cytosolic ACAT2 0.0418
6677 Myelin P2 protein PMP2 0.0365
5226 Protein ninB ninB 0.0364
2517 Subtilisin BPN' apr 0.0347
3766 Pyridoxamine 5'-phosphate oxidase pdxH 0.0318
2596 Acetyl-CoA acetyltransferase phbA 0.0317
1277 Alpha-1-antitrypsin SERPINA1 0.0317
2443 Azurin azu 0.0291
908 Glutathione S-transferase theta-1 GSTT1 0.0284
2826 Glucose--fructose oxidoreductase gfo 0.0283
4549 Endonuclease III HP_0602 0.0277
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0259
203 Pyridoxine-5'-phosphate oxidase PNPO 0.0255
3947 Xanthine dehydrogenase/oxidase XDH 0.0242
87 Hypoxanthine-guanine phosphoribosyltransferase HPRT1 0.0239
4035 Glutathione S-transferase Mu 5 GSTM5 0.0222
903 Glutathione S-transferase A5 GSTA5 0.0221
899 Glutathione S-transferase Mu 3 GSTM3 0.0215
900 Glutathione S-transferase A4 GSTA4 0.0214
4034 Glutaredoxin-1 GLRX 0.0212
4037 Hypothetical protein GPX1 0.0212
4297 Hypothetical protein SP_1951 0.0212
4521 Hypothetical protein BC_2969 0.0212
4540 Hypothetical protein TM_1070 0.0212
4555 Hypothetical protein MT1739 0.0212
4569 Hypothetical protein mshD 0.0212
4578 Hypothetical protein PA3270 0.0212
4747 Hypothetical protein PA3967 0.0212
5177 Hypothetical protein TM_0096 0.0212
5194 Hypothetical protein PA1204 0.0212
5240 Hypothetical protein Rv2991 0.0212
5370 Hypothetical protein TM_1158 0.0212
5710 Hypothetical protein Tb927.5.1360 0.0212
906 Glutathione peroxidase 1 GPX1 0.0212
1928 Leukotriene C4 synthase LTC4S 0.0212
4043 Glutaredoxin-2, mitochondrial GLRX2 0.0212
4032 Microsomal glutathione S-transferase 1 MGST1 0.0212
4039 CDNA FLJ23636 fis, clone CAS07176 GPX8 0.0212
4036 Glutathione peroxidase 6 GPX6 0.0212
4030 Thioredoxin domain-containing protein 12 TXNDC12 0.0212
4029 Microsomal glutathione S-transferase 3 MGST3 0.0212
907 Glutathione peroxidase 2 GPX2 0.0212
911 Glutathione peroxidase 3 GPX3 0.0212
910 Epididymal secretory glutathione peroxidase GPX5 0.0212
4042 Glutathione transferase omega-2 GSTO2 0.0212
4040 Glutathione peroxidase 7 GPX7 0.0212
4038 Glutathione peroxidase 4 GPX4 0.0212
1975 Phospholipid hydroperoxide glutathione peroxidase, mitochondrial GPX4 0.0212
4033 S-formylglutathione hydrolase ESD 0.0212
1056 Gamma-glutamyltranspeptidase 1 GGT1 0.0212
1405 Thiopurine S-methyltransferase TPMT 0.0212
905 Glutathione transferase omega-1 GSTO1 0.021
898 Glutathione S-transferase A3 GSTA3 0.0205
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0202
4527 Putative hydrolase ycdX ycdX 0.02
4529 Oxalate decarboxylase oxdC oxdC 0.02
4545 Molybdopterin-converting factor subunit 2 moaE 0.02
658 Para-aminobenzoate synthase component 1 pabB 0.02
4524 Mannose-6-phosphate isomerase yvyI 0.02
4547 Iron binding protein FbpA fbpA 0.02
4106 Guanylate kinase GUK1 0.02
4516 Guanylate kinase gmk 0.02
4546 Aminotransferase, putative TM_1131 0.02
4536 Transcriptional regulator, IclR family TM_0065 0.02
2501 Protein ygbM ygbM 0.02
4514 Citrate lyase beta subunit-like protein citE 0.02
4781 Citrate lyase beta subunit-like protein DR_1240 0.02
4526 Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein TM_1223 0.02
4535 Glutaconyl-CoA decarboxylase subunit alpha gcdA 0.02
4522 Arginine N-succinyltransferase subunit alpha astA 0.02
4548 Gyrase B gyrB 0.02
4538 Hypothetical protein VC1899 VC_1899 0.02
4515 Peripheral plasma membrane protein CASK CASK 0.02
897 Glutathione S-transferase kappa 1 GSTK1 0.0199
3319 Hydroxyacylglutathione hydrolase HAGH 0.0198
909 Maleylacetoacetate isomerase GSTZ1 0.0194
2165 Glutathione S-transferase Mu 2 GSTM2 0.0185
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0179
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0178
4512 Cytochrome P450 3A4 CYP3A4 0.0176
4533 Glyoxalase family protein BC_1747 0.0174
3237 Beta-lactamase OXA-2 bla 0.0174
4542 Glutaminase 1 glsA1 0.0174
4544 Glutaminase 1 glsA1 0.0174
56 Delta-aminolevulinic acid dehydratase ALAD 0.0174
2356 Delta-aminolevulinic acid dehydratase hemB 0.0174
3613 Delta-aminolevulinic acid dehydratase hemB 0.0174
3674 Delta-aminolevulinic acid dehydratase hemB 0.0174
4528 Phenazine biosynthesis protein PhzD phzD1 0.0174
4517 Probable butyrate kinase 2 buk2 0.0174
3261 Signal recognition particle protein ffh 0.0174
4496 C-terminal-binding protein 1 CTBP1 0.0174
2929 (S)-2-haloacid dehalogenase dhlB 0.0174
2995 (S)-2-haloacid dehalogenase Not Available 0.0174
4532 Gephyrin GPHN 0.0174
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0171
3583 6-phosphogluconolactonase pgl 0.016
2775 Dihydroorotate dehydrogenase pyrD 0.016
3467 Methylglyoxal synthase mgsA 0.016
4531 Putative ketoacyl reductase actIII 0.016
2230 Catalase CAT 0.016
3249 Catalase katA 0.016
3625 Catalase katA 0.016
4539 Catalase katA 0.016
4941 Catalase katB 0.016
810 Heme oxygenase 1 HMOX1 0.0157
3391 Heme oxygenase 1 pbsA1 0.0157
2525 3-phosphoshikimate 1-carboxyvinyltransferase aroA 0.0151
3201 3-phosphoshikimate 1-carboxyvinyltransferase aroA 0.0151
207 Glutathione synthetase GSS 0.015
5269 Glutathione synthetase gshB 0.015
2688 Peptide deformylase def 0.0145
2708 Peptide deformylase def 0.0145
3004 Peptide deformylase def 0.0145
4337 Peptide deformylase def 0.0145
4338 Peptide deformylase def 0.0145
5368 Peptide deformylase def 0.0145
5371 Peptide deformylase def 0.0145
6375 Peptide deformylase def 0.0145
6378 Peptide deformylase def 0.0145
6379 Peptide deformylase def 0.0145
6776 Peptide deformylase def 0.0145
6900 Peptide deformylase def 0.0145
4534 Cytohesin-2 CYTH2 0.0145
2548 Subtilisin Carlsberg apr 0.014
862 Multidrug resistance-associated protein 1 ABCC1 0.0139
4269 Hypoxanthine-guanine phosphoribosyltransferase, putative HGPRTase 0.0136
6163 Copper-transporting ATPase 2 ATP7B 0.0135
6165 Copper-transporting ATPase 1 ATP7A 0.0135
714 Glutathione reductase, mitochondrial GSR 0.0131
6146 High affinity copper uptake protein 1 SLC31A1 0.0128
6136 Multidrug resistance-associated protein 5 ABCC5 0.0122
2164 Multidrug resistance-associated protein 4 ABCC4 0.012
760 Fibroblast growth factor 1 FGF1 0.0118
3027 Streptavidin Not Available 0.0116
500 Monocarboxylate transporter 4 SLC16A3 0.0113
6137 Multidrug resistance-associated protein 6 ABCC6 0.0105
76 Nitric-oxide synthase, brain NOS1 0.0101
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.01
5682 Ribonuclease pancreatic RNASE1 0.01
1757 Myeloperoxidase MPO 0.01
1588 Multidrug resistance protein 1 ABCB1 0.0097
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0097
6042 Prostaglandin reductase 2 PTGR2 0.0082
290 Prostaglandin G/H synthase 2 PTGS2 0.0078
357 Carbonic anhydrase 2 CA2 0.0073
6043 Putative G-protein coupled receptor 44 GPR44 0.0071
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0066
2981 Phospholipase A2, membrane associated PLA2G2A 0.0062
4200 Cytochrome P450 1A2 CYP1A2 0.0062
587 Serum albumin ALB 0.0061
6432 Transporter snf 0.0061
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0058
6013 Cytochrome P450 2E1 CYP2E1 0.0058
20 Prostaglandin G/H synthase 1 PTGS1 0.0055
3709 Glycerol uptake facilitator protein glpF 0.0055
3116 Bacterioferritin bfr 0.0055
4906 Bacterioferritin bfr 0.0055
4965 Bacterioferritin bfr 0.0055
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0055
3173 Enolase eno 0.0055
3393 TGF-beta receptor type-2 TGFBR2 0.0055
3238 Multidrug resistance protein mexA mexA 0.0055
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0055
6016 Cytochrome P450 2C19 CYP2C19 0.0053
708 Alpha-tocopherol transfer protein TTPA 0.0052
4077 Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform PPP2CB 0.0052
86 SEC14-like protein 4 SEC14L4 0.0052
283 SEC14-like protein 2 SEC14L2 0.0052
375 SEC14-like protein 3 SEC14L3 0.0052
4076 Diacylglycerol kinase alpha DGKA 0.0052
4078 Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform PPP2CA 0.005
997 Protein kinase C beta type PRKCB 0.005
6141 Sodium/bile acid cotransporter SLC10A1 0.0049
4604 Liver carboxylesterase 1 CES1 0.0049
2852 DNA mismatch repair protein mutL mutL 0.0048
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0046
1970 Protein kinase C alpha type PRKCA 0.0045
6459 Glycodelin PAEP 0.0045
3191 Histidinol dehydrogenase hisD 0.0044
3221 Cytochrome c4 cc4 0.0044
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0044
6144 Solute carrier family 22 member 2 SLC22A2 0.0043
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0043
186 Glutamate--cysteine ligase catalytic subunit GCLC 0.0043
436 5-hydroxytryptamine 2B receptor HTR2B 0.0042
740 Argininosuccinate synthase ASS1 0.0041
865 Argininosuccinate synthase ASS1 0.0041
2680 Argininosuccinate synthase argG 0.0041
3194 Argininosuccinate synthase argG 0.0041
4192 DNA topoisomerase 2-beta TOP2B 0.0041
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0041
4311 tRNA TRDMT1 0.0041
4325 tRNA trmD 0.0041
4328 tRNA trmD 0.0041
4692 A/G-specific adenine glycosylase mutY 0.004
4757 Cytochrome P450 2C9 CYP2C9 0.004
2802 Endoglucanase G celCCG 0.0039
1024 Solute carrier family 22 member 11 SLC22A11 0.0039
6316 ADP-ribosylation factor 1 ARF1 0.0038
590 5-hydroxytryptamine 2C receptor HTR2C 0.0037
6143 Solute carrier family 22 member 7 SLC22A7 0.0037
824 Sodium-dependent serotonin transporter SLC6A4 0.0037
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0037
5448 Ribonuclease Z rnz 0.0035
5449 Hypothetical gliding protein mglB 0.0035
3781 Thiol:disulfide interchange protein dsbC precursor dsbC 0.0035
4705 Manganese catalase Not Available 0.0035
5439 33 kDa chaperonin hslO 0.0035
332 Beta-lactamase blaZ 0.0035
2478 Beta-lactamase ampC 0.0035
2613 Beta-lactamase ampC 0.0035
2635 Beta-lactamase ampC 0.0035
2700 Beta-lactamase penP 0.0035
5445 Beta-lactamase blaB 0.0035
6019 Beta-lactamase SHV-7 0.0035
6701 Beta-lactamase cphA 0.0035
5443 UPF0189 protein ymdB ymdB 0.0035
5446 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase HI_1679 0.0035
5440 UPF0067 protein yebR yebR 0.0035
2720 Copper-containing nitrite reductase nirK 0.0035
5454 Internalin-A inlA 0.0035
5447 Lethal(3)malignant brain tumor-like protein L3MBTL1 0.0035
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0035
4498 Ornithine cyclodeaminase PP3533 0.0034
6142 Solute carrier family 22 member 8 SLC22A8 0.0034
502 5-hydroxytryptamine 2A receptor HTR2A 0.0033
444 Alcohol dehydrogenase 1B ADH1B 0.0033
3923 Cholinesterase BCHE 0.0033
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0032
275 Arachidonate 5-lipoxygenase ALOX5 0.0032
5450 Prolyl endopeptidase Pep pep 0.0031
4771 Dissimilatory copper-containing nitrite reductase nir 0.0031
3356 Diaminopimelate decarboxylase lysA 0.0031
2714 Chorismate mutase aroH 0.0031
4611 Chorismate mutase aroG 0.0031
3274 Hydroxylamine reductase hcp 0.0031
4804 Hydroxylamine reductase hcp 0.0031
1729 Solute carrier family 22 member 6 SLC22A6 0.0031
3736 Glyceraldehyde-3-phosphate dehydrogenase A gapA 0.003
6148 Multidrug resistance-associated protein 7 ABCC10 0.003
3399 Limonene-1,2-epoxide hydrolase limA 0.0029
3462 Tyrosine-protein kinase transforming protein Abl ABL 0.0028
3697 Bifunctional protein glmU [Includes: UDP-N-acetylglucosamine pyrophosphorylase glmU 0.0028
6147 Solute carrier family 22 member 3 SLC22A3 0.0028
597 Dihydropteridine reductase QDPR 0.0028
817 DNA topoisomerase 2-alpha TOP2A 0.0028
1898 Cytochrome P450 1B1 CYP1B1 0.0027
5180 L(+)-mandelate dehydrogenase mdlB 0.0027
3500 Putative family 31 glucosidase yicI yicI 0.0027
4608 Putative cytochrome P450 SCO1207 0.0027
4963 Putative cytochrome P450 SCO2884 0.0027
6254 Putative cytochrome P450 SCO6998 0.0027
3480 Mannan endo-1,4-beta-mannosidase manA 0.0027
577 Argininosuccinate lyase ASL 0.0026
468 Cytochrome P450 4A11 CYP4A11 0.0026
1615 Chymase CMA1 0.0026
2597 Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] glmS 0.0025
4119 Cytochrome P450 2D6 CYP2D6 0.0025
365 Dihydrofolate reductase DHFR 0.0024
2381 Dihydrofolate reductase DFR1 0.0024
2833 Dihydrofolate reductase Not Available 0.0024
2931 Dihydrofolate reductase folA 0.0024
3544 Dihydrofolate reductase folA 0.0024
3682 Dihydrofolate reductase folA 0.0024
6642 Dihydrofolate reductase folA 0.0024
6756 Dihydrofolate reductase dfrA 0.0024
287 Beta-1,4-galactosyltransferase 1 B4GALT1 0.0024
6145 Solute carrier family 22 member 1 SLC22A1 0.0024
6024 Cytochrome P450 1A1 CYP1A1 0.0022
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0019
4118 Cytochrome P450 3A5 CYP3A5 0.0019
4924 Cytochrome P450 2C8 CYP2C8 0.0019
6030 Cytochrome P450 2B6 CYP2B6 0.0017
474 Acetylcholinesterase ACHE 0.0015
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