DT-Web

DB01622 - Thioproperazine


Identification
Name Thioproperazine
Accession Number DB01622
Type small molecule
Description Thioproperazine is a potent neuroleptic with antipsychotic properties. Thioproperazine has a marked cataleptic and antiapomorphine activity associated with relatively slight sedative, hypothermic and spasmolytic effects. It is virtually without antiserotonin and hypotensive action and has no antihistaminic property. It is used for the treatment of all types of acute and chronic schizophrenia, including those which did not respond to the usual neuroleptics; manic syndromes. Overdosage may result in severe extrapyramidal symptoms with dysphagia, marked sialorrhea, persistent and rapidly increasing hyperthermia, pulmonary syndrome, state of shock with pallor and profuse sweating, which may be followed by collapse and coma. LD50 in mice is 70 mg/kg I.V., 120 mg/kg I.P., 500 mg/kg S.C. and 830 mg/kg P.O.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 446.629
Groups approved
Monoisotopic Weight 446.181017604
Pharmacology
Indication For the treatment of all types of acute and chronic schizophrenia, including those which did not respond to the usual neuroleptics; manic syndromes.
Mechanism of action Thioproperazine acts as an antagonist (blocking agent) on different postsysnaptic receptors -on dopaminergic-receptors (subtypes D1, D2, D3 and D4 - different antipsychotic properties on productive and unproductive symptoms), on serotonergic-receptors (5-HT1 and 5-HT2, with anxiolytic, antidepressive and antiaggressive properties as well as an attenuation of extrapypramidal side-effects, but also leading to weight gain, fall in blood pressure, sedation and ejaculation difficulties), on histaminergic-receptors (H1-receptors, sedation, antiemesis, vertigo, fall in blood pressure and weight gain), alpha1/alpha2-receptors (antisympathomimetic properties, lowering of blood pressure, reflex tachycardia, vertigo, sedation, hypersalivation and incontinence as well as sexual dysfunction, but may also attenuate pseudoparkinsonism - controversial) and finally on muscarinic (cholinergic) M1/M2-receptors (causing anticholinergic symptoms like dry mouth, blurred vision, obstipation, difficulty/inability to urinate, sinus tachycardia, ECG-changes and loss of memory, but the anticholinergic action may attenuate extrapyramidal side-effects).
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Overdosage may result in severe extrapyramidal symptoms with dysphagia, marked sialorrhea, persistent and rapidly increasing hyperthermia, pulmonary syndrome, state of shock with pallor and profuse sweating, which may be followed by collapse and coma. LD50 in mice is 70 mg/kg I.V., 120 mg/kg I.P., 500 mg/kg S.C. and 830 mg/kg P.O.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Donepezil Possible antagonism of action
Galantamine Possible antagonism of action
Rivastigmine Possible antagonism of action
Food Interactions
  • Avoid alcohol
  • Take with food to avoid irritation

Targets


D(2) dopamine receptor
Name D(2) dopamine receptor
Gene Name DRD2
Pharmacological action yes
Actions antagonist
References
  • Oades RD, Rao ML, Bender S, Sartory G, Muller BW: Neuropsychological and conditioned blocking performance in patients with schizophrenia: assessment of the contribution of neuroleptic dose, serum levels and dopamine D2-receptor occupancy. Behav Pharmacol. 2000 Jun;11(3-4):317-30. - Pubmed
  • Seeman P: Atypical antipsychotics: mechanism of action. Can J Psychiatry. 2002 Feb;47(1):27-38. - Pubmed
  • Wu S, Xing Q, Gao R, Li X, Gu N, Feng G, He L: Response to chlorpromazine treatment may be associated with polymorphisms of the DRD2 gene in Chinese schizophrenic patients. Neurosci Lett. 2005 Mar 7;376(1):1-4. Epub 2004 Dec 2. - Pubmed
  • Wu SN, Gao R, Xing QH, Li HF, Shen YF, Gu NF, Feng GY, He L: Association of DRD2 polymorphisms and chlorpromazine-induced extrapyramidal syndrome in Chinese schizophrenic patients. Acta Pharmacol Sin. 2006 Aug;27(8):966-70. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
  • Seeman P: Dopamine D2 receptors as treatment targets in schizophrenia. Clin Schizophr Relat Psychoses. 2010 Apr;4(1):56-73. - Pubmed
DTHybrid score 0.5224
D(1A) dopamine receptor
Name D(1A) dopamine receptor
Gene Name DRD1
Pharmacological action unknown
Actions antagonist
References
  • Kanba S, Suzuki E, Nomura S, Nakaki T, Yagi G, Asai M, Richelson E: Affinity of neuroleptics for D1 receptor of human brain striatum. J Psychiatry Neurosci. 1994 Jul;19(4):265-9. - Pubmed
DTHybrid score 0.4186
5-hydroxytryptamine 2A receptor
Name 5-hydroxytryptamine 2A receptor
Gene Name HTR2A
Pharmacological action yes
Actions antagonist
References
  • Kusumi I, Takahashi Y, Suzuki K, Kameda K, Koyama T: Differential effects of subchronic treatments with atypical antipsychotic drugs on dopamine D2 and serotonin 5-HT2A receptors in the rat brain. J Neural Transm. 2000;107(3):295-302. - Pubmed
  • Yamada J, Sugimoto Y, Horisaka K: Serotonin2 (5-HT2) receptor agonist 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) inhibits chlorpromazine- and haloperidol-induced hypothermia in mice. Biol Pharm Bull. 1995 Nov;18(11):1580-3. - Pubmed
DTHybrid score 0.4362
5-hydroxytryptamine 1A receptor
Name 5-hydroxytryptamine 1A receptor
Gene Name HTR1A
Pharmacological action yes
Actions antagonist
References
  • Cosi C, Koek W: Agonist, antagonist, and inverse agonist properties of antipsychotics at human recombinant 5-HT(1A) receptors expressed in HeLa cells. Eur J Pharmacol. 2001 Dec 14;433(1):55-62. - Pubmed
  • Newman-Tancredi A, Gavaudan S, Conte C, Chaput C, Touzard M, Verriele L, Audinot V, Millan MJ: Agonist and antagonist actions of antipsychotic agents at 5-HT1A receptors: a [35S]GTPgammaS binding study. Eur J Pharmacol. 1998 Aug 21;355(2-3):245-56. - Pubmed
DTHybrid score 0.3534
Alpha-1A adrenergic receptor
Name Alpha-1A adrenergic receptor
Gene Name ADRA1A
Pharmacological action yes
Actions antagonist
References
  • Cahir M, King DJ: Antipsychotics lack alpha 1A/B adrenoceptor subtype selectivity in the rat. Eur Neuropsychopharmacol. 2005 Mar;15(2):231-4. - Pubmed
DTHybrid score 0.533
Alpha-1B adrenergic receptor
Name Alpha-1B adrenergic receptor
Gene Name ADRA1B
Pharmacological action yes
Actions antagonist
References
  • Cahir M, King DJ: Antipsychotics lack alpha 1A/B adrenoceptor subtype selectivity in the rat. Eur Neuropsychopharmacol. 2005 Mar;15(2):231-4. - Pubmed
DTHybrid score 0.3773

Transporters


Solute carrier family 22 member 1
Name Solute carrier family 22 member 1
Gene Name SLC22A1
Actions inhibitor
References
  • Bednarczyk D, Ekins S, Wikel JH, Wright SH: Influence of molecular structure on substrate binding to the human organic cation transporter, hOCT1. Mol Pharmacol. 2003 Mar;63(3):489-98. - Pubmed
DTHybrid score 0.2611

Carriers


Solute carrier family 22 member 1
Name Solute carrier family 22 member 1
Gene Name SLC22A1
Actions
References Not Available
DTHybrid score 0.2611

Predictions


Id Partner name Gene Name Score
4119 Cytochrome P450 2D6 CYP2D6 0.2672
318 Alpha-2A adrenergic receptor ADRA2A 0.2523
4512 Cytochrome P450 3A4 CYP3A4 0.2257
590 5-hydroxytryptamine 2C receptor HTR2C 0.183
789 Alpha-1D adrenergic receptor ADRA1D 0.1641
1588 Multidrug resistance protein 1 ABCB1 0.1609
4200 Cytochrome P450 1A2 CYP1A2 0.159
638 D(3) dopamine receptor DRD3 0.1586
432 D(4) dopamine receptor DRD4 0.1574
629 Alpha-2B adrenergic receptor ADRA2B 0.1543
378 Alpha-2C adrenergic receptor ADRA2C 0.1476
163 D(1B) dopamine receptor DRD5 0.1293
492 Histamine H1 receptor HRH1 0.1173
885 5-hydroxytryptamine 1B receptor HTR1B 0.1154
725 5-hydroxytryptamine 1D receptor HTR1D 0.1131
103 Muscarinic acetylcholine receptor M1 CHRM1 0.1053
436 5-hydroxytryptamine 2B receptor HTR2B 0.0991
4757 Cytochrome P450 2C9 CYP2C9 0.0955
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0949
716 5-hydroxytryptamine 7 receptor HTR7 0.094
6016 Cytochrome P450 2C19 CYP2C19 0.0938
6144 Solute carrier family 22 member 2 SLC22A2 0.0848
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0842
4118 Cytochrome P450 3A5 CYP3A5 0.0805
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0747
193 Beta-1 adrenergic receptor ADRB1 0.0721
824 Sodium-dependent serotonin transporter SLC6A4 0.0707
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0694
766 Beta-2 adrenergic receptor ADRB2 0.069
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0675
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0672
1256 5-hydroxytryptamine 6 receptor HTR6 0.0624
6107 Cytochrome P450 3A7 CYP3A7 0.0616
713 Sodium-dependent dopamine transporter SLC6A3 0.0592
6013 Cytochrome P450 2E1 CYP2E1 0.055
4924 Cytochrome P450 2C8 CYP2C8 0.0484
3941 Amine oxidase [flavin-containing] A MAOA 0.047
131 Synaptic vesicular amine transporter SLC18A2 0.0458
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0442
6030 Cytochrome P450 2B6 CYP2B6 0.0438
6147 Solute carrier family 22 member 3 SLC22A3 0.0431
118 Organic cation/carnitine transporter 2 SLC22A5 0.0389
341 5-hydroxytryptamine 3 receptor HTR3A 0.0378
1729 Solute carrier family 22 member 6 SLC22A6 0.0346
94 5-hydroxytryptamine 4 receptor HTR4 0.0345
3923 Cholinesterase BCHE 0.0338
528 5-hydroxytryptamine 1E receptor HTR1E 0.0326
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0314
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0292
465 Calmodulin CALM1 0.0287
20 Prostaglandin G/H synthase 1 PTGS1 0.0287
6142 Solute carrier family 22 member 8 SLC22A8 0.0286
833 Organic cation/carnitine transporter 1 SLC22A4 0.0264
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0247
6024 Cytochrome P450 1A1 CYP1A1 0.0241
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0234
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0227
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0227
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0222
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0216
511 5-hydroxytryptamine 1F receptor HTR1F 0.0216
474 Acetylcholinesterase ACHE 0.0213
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0213
1517 Beta-3 adrenergic receptor ADRB3 0.0209
891 Dihydropteroate synthase folP 0.0207
5359 Dihydropteroate synthase folP 0.0207
7175 Dihydropteroate synthase sulI 0.0207
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0204
124 Histamine H2 receptor HRH2 0.0201
174 Sigma 1-type opioid receptor SIGMAR1 0.0194
6106 Cytochrome P450 2C18 CYP2C18 0.0192
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0186
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0186
290 Prostaglandin G/H synthase 2 PTGS2 0.018
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0175
776 Bile salt export pump ABCB11 0.017
1389 Transforming growth factor beta-1 TGFB1 0.0169
1024 Solute carrier family 22 member 11 SLC22A11 0.016
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0159
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0157
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0156
6143 Solute carrier family 22 member 7 SLC22A7 0.0155
3426 Glutamine synthetase glnA 0.0155
3987 Glutamine synthetase GLUL 0.0155
828 Phenylalanine-4-hydroxylase PAH 0.0152
3109 Phenylalanine-4-hydroxylase phhA 0.0152
923 Glutamate receptor 3 GRIA3 0.0149
862 Multidrug resistance-associated protein 1 ABCC1 0.0143
6541 Peptostreptococcal albumin-binding protein pab 0.0142
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0136
3939 Amine oxidase [flavin-containing] B MAOB 0.0135
5718 Cytochrome P450 2A6 CYP2A6 0.0131
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0129
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0127
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0123
2164 Multidrug resistance-associated protein 4 ABCC4 0.0119
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0119
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0119
6138 Multidrug resistance protein 3 ABCB4 0.0113
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0105
756 Sex hormone-binding globulin SHBG 0.0104
1636 Trace amine-associated receptor 1 TAAR1 0.0102
1656 CYP2B protein CYP2B 0.0101
2211 Fatty acid-binding protein, heart FABP3 0.0098
509 Thymidine kinase TK 0.0097
570 Thymidine kinase TK 0.0097
2559 Thymidine kinase TK 0.0097
3430 Thymidine kinase tdk 0.0097
3518 Thymidine kinase TK 0.0097
5301 Thymidine kinase tdk 0.0097
5771 Thymidine kinase ORF36 0.0097
7009 Thymidine kinase ORF36 0.0097
566 Serotransferrin TF 0.0094
1898 Cytochrome P450 1B1 CYP1B1 0.0094
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0094
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0094
921 Glutamate receptor 2 GRIA2 0.0092
6432 Transporter snf 0.0091
672 Prostaglandin F2-alpha receptor PTGFR 0.009
164 Histamine H4 receptor HRH4 0.0085
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0084
6151 Monocarboxylate transporter 10 SLC16A10 0.0084
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0082
6525 Group IID secretory phospholipase A2 PLA2G2D 0.008
696 Kappa-type opioid receptor OPRK1 0.0078
694 Matrix protein 2 M 0.0078
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0077
3704 Spermidine/putrescine-binding periplasmic protein precursor potD 0.0077
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0077
6859 Protein S100-A4 S100A4 0.0076
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0075
6141 Sodium/bile acid cotransporter SLC10A1 0.0074
338 DNA polymerase UL30 0.0073
379 DNA polymerase UL54 0.0073
697 DNA polymerase ORF28 0.0073
2482 DNA polymerase 43 0.0073
4104 DNA polymerase BALF5 0.0073
3947 Xanthine dehydrogenase/oxidase XDH 0.0073
6010 Thiamine transporter 1 SLC19A2 0.0073
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0072
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0072
543 Penicillin-binding protein 1B mrcB 0.0072
6186 Penicillin-binding protein 1B ponB 0.0072
6822 Penicillin-binding protein 1b pbp1b 0.0072
6844 Penicillin-binding protein 1b pbp1b 0.0072
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0072
1 Peptidoglycan synthetase ftsI ftsI 0.0071
4155 Peptidoglycan synthetase ftsI ftsI 0.0071
645 Penicillin-binding protein 1A mrcA 0.0071
5805 Penicillin-binding protein 1A ponA 0.0071
6185 Penicillin-binding protein 1A mrcA 0.0071
6799 Penicillin-binding protein 1A pbpA 0.0071
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.007
738 Monocarboxylate transporter 1 SLC16A1 0.0069
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0067
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0067
3560 Gentamicin 3'-acetyltransferase aacC1 0.0067
136 Estrogen receptor ESR1 0.0066
36 Insulin receptor INSR 0.0066
183 Vascular endothelial growth factor A VEGFA 0.0066
175 Thiamin pyrophosphokinase 1 TPK1 0.0066
380 Cytochrome P450 17A1 CYP17A1 0.0065
847 Mu-type opioid receptor OPRM1 0.0064
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0063
537 ATP synthase delta chain, mitochondrial ATP5D 0.0063
1119 Peroxiredoxin-5, mitochondrial PRDX5 0.0063
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0063
281 5'-AMP-activated protein kinase subunit beta-1 PRKAB1 0.0063
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0061
705 Glutamate receptor 1 GRIA1 0.0061
482 Glycine receptor subunit alpha-1 GLRA1 0.006
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.006
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0059
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0059
6085 Fatty acid-binding protein, intestinal FABP2 0.0058
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0057
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0057
4773 Deoxycytidine kinase DCK 0.0057
1618 High affinity nerve growth factor receptor NTRK1 0.0057
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0056
731 HIV-1 protease HIV-1 protease 0.0054
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0054
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0054
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0054
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0053
2853 14 kDa fatty acid-binding protein Not Available 0.0053
6148 Multidrug resistance-associated protein 7 ABCC10 0.0053
467 Delta-type opioid receptor OPRD1 0.0051
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0051
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0051
869 Estrogen receptor beta ESR2 0.0051
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.005
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.005
6027 Alkaline phosphatase, tissue-nonspecific isozyme ALPL 0.005
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0049
6171 Solute carrier family 28 member 3 SLC28A3 0.0049
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0049
153 Dopamine beta-hydroxylase DBH 0.0048
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0048
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0048
6184 D-alanyl-D-alanine carboxypeptidase dacC dacC 0.0048
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0048
2183 Fatty acid-binding protein, adipocyte FABP4 0.0047
3382 Glycolipid transfer protein GLTP 0.0046
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0046
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0045
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0045
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0045
303 Diamine acetyltransferase 2 SAT2 0.0045
623 Spermine oxidase SMOX 0.0045
1317 Spermine synthase SMS 0.0045
233 Potassium channel subfamily K member 2 KCNK2 0.0045
115 Penicillin-binding protein 2 mrdA 0.0044
6069 Penicillin-binding protein 2 mrdA 0.0044
6118 Penicillin-binding protein 2 penA 0.0044
6187 Penicillin-binding protein 2 pbpA 0.0044
6686 Penicillin-binding protein 2 pbp2 0.0044
6939 Penicillin-binding protein 2 mrdA 0.0044
7163 Penicillin-binding protein 2 pbpA 0.0044
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0044
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0044
373 Transthyretin TTR 0.0044
5645 DNA topoisomerase 4 subunit B parE 0.0044
6227 DNA topoisomerase 4 subunit B parE 0.0044
887 DNA gyrase subunit B gyrB 0.0044
4150 DNA gyrase subunit B gyrB 0.0044
6225 DNA gyrase subunit B gyrB 0.0044
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0043
3755 Nucleoside-specific channel-forming protein tsx precursor tsx 0.0043
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0042
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0042
844 Epidermal growth factor receptor EGFR 0.0041
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0041
6070 Nischarin NISCH 0.0041
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0041
404 DNA gyrase subunit A gyrA 0.004
6224 DNA gyrase subunit A gyrA 0.004
477 DNA topoisomerase 4 subunit A parC 0.004
886 DNA topoisomerase 4 subunit A parC 0.004
6226 DNA topoisomerase 4 subunit A parC 0.004
123 Diamine acetyltransferase 1 SAT1 0.004
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.004
558 Solute carrier family 12 member 1 SLC12A1 0.004
6508 Putative uncharacterized protein srtB 0.004
6543 Putative uncharacterized protein tcp14 0.004
6615 Putative uncharacterized protein MT0785 0.004
6623 Putative uncharacterized protein Not Available 0.004
6806 Putative uncharacterized protein AGR_C_2535 0.004
6813 Putative uncharacterized protein SAV4671 0.004
6815 Putative uncharacterized protein AFE_1514 0.004
6819 Putative uncharacterized protein RUMGNA_03254 0.004
6825 Putative uncharacterized protein CV_3270 0.004
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.004
4161 Furin FURIN 0.004
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0039
4604 Liver carboxylesterase 1 CES1 0.0039
1360 Sphingomyelin phosphodiesterase SMPD1 0.0039
3810 Catechol O-methyltransferase COMT 0.0039
6067 Penicillin binding protein 2a mecA 0.0038
2472 Voltage-gated potassium channel kcsA 0.0038
6366 Voltage-gated potassium channel kcsA 0.0038
904 Glutathione S-transferase P GSTP1 0.0037
70 Type-1 angiotensin II receptor AGTR1 0.0036
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0036
146 Androgen receptor AR 0.0036
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0036
819 Penicillin-binding protein 4 dacB 0.0036
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0036
1830 5'-nucleotidase NT5E 0.0035
6136 Multidrug resistance-associated protein 5 ABCC5 0.0035
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0034
125 DNA polymerase beta POLB 0.0034
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0034
427 Substance-P receptor TACR1 0.0034
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0033
2178 Metabotropic glutamate receptor 5 GRM5 0.0033
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0033
2251 Thymidylate kinase tmk 0.0033
2254 Thymidylate kinase DTYMK 0.0033
3522 Thymidylate kinase tmk 0.0033
3478 Glucose-1-phosphate thymidylyltransferase rmlA 0.0032
4277 Glucose-1-phosphate thymidylyltransferase rmlA 0.0032
594 Thyroxine-binding globulin SERPINA7 0.0032
6677 Myelin P2 protein PMP2 0.0032
3811 Cytochrome P450 19A1 CYP19A1 0.0032
595 Fibrinogen alpha chain FGA 0.0032
6149 Solute carrier family 22 member 10 SLC22A10 0.0032
2257 Uridine phosphorylase udp 0.0031
5132 Uridine phosphorylase udp 0.0031
449 Ornithine decarboxylase ODC1 0.0031
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0031
3760 Penicillin-binding protein 5 precursor dacA 0.0031
749 Amiloride-sensitive cation channel 1, neuronal ACCN1 0.003
758 Thyroid hormone receptor alpha THRA 0.003
459 Retinoic acid receptor RXR-alpha RXRA 0.003
3611 Cytidine deaminase cdd 0.003
3707 Cytidine deaminase cdd 0.003
4211 Cytidine deaminase CDA 0.003
4120 NADPH--cytochrome P450 reductase POR 0.003
3813 Fibrinogen gamma chain FGG 0.0029
3812 Fibrinogen beta chain [Contains: Fibrinopeptide B] FGB 0.0029
5126 Arginase rocF 0.0029
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0029
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0029
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0029
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0029
3932 Glutathione S-transferase A2 GSTA2 0.0029
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0028
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0028
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0028
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0028
1341 Histamine H3 receptor HRH3 0.0028
1278 Pro-epidermal growth factor EGF 0.0028
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0028
6014 Cytochrome P450 2A13 CYP2A13 0.0027
387 Amiloride-sensitive amine oxidase [copper-containing] ABP1 0.0027
7187 Amiloride-sensitive amine oxidase [copper-containing] ABP1 0.0027
346 Thyroid hormone receptor beta-1 THRB 0.0027
827 Sodium/hydrogen exchanger 1 SLC9A1 0.0027
6111 DNA polymerase epsilon subunit 4 POLE4 0.0027
889 3-oxoacyl-[acyl-carrier-protein] synthase 1 fabB 0.0027
6860 3-oxoacyl-[acyl-carrier-protein] synthase 1 kasA 0.0027
740 Argininosuccinate synthase ASS1 0.0027
865 Argininosuccinate synthase ASS1 0.0027
2680 Argininosuccinate synthase argG 0.0027
3194 Argininosuccinate synthase argG 0.0027
6112 DNA polymerase epsilon subunit 3 POLE3 0.0027
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0026
6108 Ribonucleoside-diphosphate reductase subunit M2 B RRM2B 0.0026
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0026
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0026
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0026
6110 DNA polymerase epsilon subunit 2 POLE2 0.0026
6109 DNA polymerase epsilon catalytic subunit A POLE 0.0026
122 P2Y purinoceptor 12 P2RY12 0.0026
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0026
4252 Penicillin-binding protein 5 dacA 0.0025
6043 Putative G-protein coupled receptor 44 GPR44 0.0025
614 Progesterone receptor PGR 0.0024
811 Translocator protein TSPO 0.0024
1864 RET proto-oncogene RET 0.0024
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0024
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0024
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0024
1867 Major prion protein PRNP 0.0024
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0024
159 Penicillin-binding protein 2B penA 0.0024
6121 Penicillin-binding protein 2B penA 0.0024
6231 Pepsin A PGA3 0.0024
633 Penicillin-binding proteins 1A/1B pbpA 0.0024
624 Guanidinoacetate N-methyltransferase GAMT 0.0023
332 Beta-lactamase blaZ 0.0023
2478 Beta-lactamase ampC 0.0023
2613 Beta-lactamase ampC 0.0023
2635 Beta-lactamase ampC 0.0023
2700 Beta-lactamase penP 0.0023
5445 Beta-lactamase blaB 0.0023
6019 Beta-lactamase SHV-7 0.0023
6701 Beta-lactamase cphA 0.0023
4218 Ribonucleoside-diphosphate reductase M2 subunit RRM2 0.0023
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0023
6102 Arylamine N-acetyltransferase 2 NAT2 0.0023
6167 Organic solute transporter subunit beta OSTB 0.0022
6166 Organic solute transporter subunit alpha OSTA 0.0022
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0022
1525 Heparin-binding growth factor 2 FGF2 0.0022
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0022
6103 Arylamine N-acetyltransferase 1 NAT1 0.0022
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0022
6218 Pannexin-1 PANX1 0.0022
707 72 kDa type IV collagenase MMP2 0.0021
4203 Histamine N-methyltransferase HNMT 0.0021
4210 Toll-like receptor 4 TLR4 0.0021
6209 30S ribosomal protein S19 rpsS 0.0021
6712 30S ribosomal protein S19 rpsS 0.0021
6726 30S ribosomal protein S19 rpsS 0.0021
6207 30S ribosomal protein S14 rpsN 0.0021
976 Platelet glycoprotein IX GP9 0.0021
1050 Bile salt sulfotransferase SULT2A1 0.0021
331 Retinol-binding protein I, cellular RBP1 0.0021
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.002
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.002
6501 Fatty acid-binding protein, liver FABP1 0.002
768 FK506-binding protein 1A FKBP1A 0.002
342 P protein [Includes: DNA-directed DNA polymerase P 0.002
612 P protein [Includes: DNA-directed DNA polymerase P 0.002
603 DNA polymerase alpha catalytic subunit POLA1 0.002
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.002
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.002
33 Cystine/glutamate transporter SLC7A11 0.002
1992 Vitamin D-binding protein GC 0.002
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0019
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0019
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0019
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0019
1374 Natriuretic peptides B NPPB 0.0019
1827 Gap junction alpha-1 protein GJA1 0.0019
1908 Vascular cell adhesion protein 1 VCAM1 0.0019
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0019
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0019
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0019
5787 Angiopoietin-1 receptor TEK 0.0019
6033 High affinity interleukin-8 receptor A CXCR1 0.0018
65 Matrix metalloproteinase-9 Not Available 0.0018
199 Monocarboxylate transporter 8 SLC16A2 0.0018
6137 Multidrug resistance-associated protein 6 ABCC6 0.0018
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0018
228 Beta platelet-derived growth factor receptor PDGFRB 0.0018
5934 Cytochrome P450 26A1 CYP26A1 0.0018
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0018
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0018
3312 Fatty acid-binding protein, brain FABP7 0.0018
1198 Serum paraoxonase/arylesterase 1 PON1 0.0018
6223 Penicillin-binding protein 1C pbpC 0.0018
5626 Nucleoside diphosphate kinase B NME2 0.0017
702 UMP-CMP kinase CMPK1 0.0017
1714 Mitogen-activated protein kinase 3 MAPK3 0.0017
1291 cAMP response element-binding protein CREB1 0.0017
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0017
229 Retinoic acid receptor beta RARB 0.0017
504 Mast/stem cell growth factor receptor KIT 0.0017
2300 Lysozyme E 0.0017
3633 Lysozyme R 0.0017
5597 Lysozyme 17 0.0017
5682 Ribonuclease pancreatic RNASE1 0.0017
780 Retinoic acid receptor RXR-gamma RXRG 0.0017
1074 Urokinase-type plasminogen activator PLAU 0.0017
730 Retinoic acid receptor alpha RARA 0.0017
3929 Phosphoethanolamine/phosphocholine phosphatase PHOSPHO1 0.0016
264 Choline/ethanolamine kinase [Includes: Choline kinase beta CHKB 0.0016
3933 Choline/ethanolaminephosphotransferase CEPT1 0.0016
1686 Choline transporter-like protein 1 SLC44A1 0.0016
3926 Choline transporter-like protein 2 SLC44A2 0.0016
861 Choline kinase alpha CHKA 0.0016
3927 Choline transporter-like protein 3 SLC44A3 0.0016
769 High-affinity choline transporter 1 SLC5A7 0.0016
700 Choline dehydrogenase, mitochondrial CHDH 0.0016
549 Choline-phosphate cytidylyltransferase B PCYT1B 0.0016
3925 Choline transporter-like protein 4 SLC44A4 0.0016
576 Choline O-acetyltransferase CHAT 0.0016
3922 Phospholipase D2 PLD2 0.0016
3924 Phospholipase D1 PLD1 0.0016
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0016
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0016
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0016
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0016
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0016
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0016
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0016
3616 Fatty acid-binding protein, epidermal FABP5 0.0016
5431 Lipid binding protein Not Available 0.0016
5433 UPF0230 protein TM_1468 TM_1468 0.0016
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0016
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0016
2207 Rhodopsin RHO 0.0016
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0016
244 Angiotensin-converting enzyme ACE 0.0016
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0016
6165 Copper-transporting ATPase 1 ATP7A 0.0016
6163 Copper-transporting ATPase 2 ATP7B 0.0016
88 Retinoic acid receptor RXR-beta RXRB 0.0016
162 Retinoic acid receptor gamma-1 RARG 0.0015
277 Purine nucleoside phosphorylase PNP 0.0015
2870 Purine nucleoside phosphorylase punA 0.0015
2945 Purine nucleoside phosphorylase punA 0.0015
4659 Purine nucleoside phosphorylase TM_1596 0.0015
4825 Purine nucleoside phosphorylase TTHA1435 0.0015
6146 High affinity copper uptake protein 1 SLC31A1 0.0015
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0015
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0015
871 Glucocorticoid receptor NR3C1 0.0014
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0014
908 Glutathione S-transferase theta-1 GSTT1 0.0014
489 Monocarboxylate transporter 2 SLC16A7 0.0014
5294 Nucleoside diphosphate kinase A NME1 0.0014
6031 Cytochrome P450 3A43 CYP3A43 0.0014
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0014
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0014
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0014
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0014
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0014
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0014
751 Potassium channel subfamily K member 6 KCNK6 0.0014
283 SEC14-like protein 2 SEC14L2 0.0013
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0013
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0013
6459 Glycodelin PAEP 0.0013
896 Glutathione S-transferase Mu 1 GSTM1 0.0013
1405 Thiopurine S-methyltransferase TPMT 0.0013
822 Aldose reductase AKR1B1 0.0012
172 Potassium channel subfamily K member 1 KCNK1 0.0012
3917 Methylenetetrahydrofolate reductase MTHFR 0.0012
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0012
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0012
3587 Gastrotropin FABP6 0.0012
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0012
4226 Uridine phosphorylase 2 UPP2 0.0012
4217 Telomerase reverse transcriptase TERT 0.0012
1757 Myeloperoxidase MPO 0.0012
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0011
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0011
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0011
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0011
24 Thymidylate synthase TMP1 0.0011
359 Thymidylate synthase TYMS 0.0011
2626 Thymidylate synthase thyA 0.0011
2729 Thymidylate synthase thyA 0.0011
5352 Thymidylate synthase THYA 0.0011
4225 Uridine phosphorylase 1 UPP1 0.0011
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0011
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0011
2981 Phospholipase A2, membrane associated PLA2G2A 0.0011
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.001
2461 D-alanyl-D-alanine carboxypeptidase Not Available 0.001
5756 D-alanyl-D-alanine carboxypeptidase dac 0.001
737 Mineralocorticoid receptor NR3C2 0.001
413 Amidophosphoribosyltransferase PPAT 0.001
2515 Amidophosphoribosyltransferase purF 0.001
3714 Amidophosphoribosyltransferase purF 0.001
2021 Thrombomodulin THBD 0.001
357 Carbonic anhydrase 2 CA2 0.001
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.001
2320 Thymidine kinase, cytosolic TK1 0.0009
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0009
1353 DNA topoisomerase 1 TOP1 0.0009
3552 DNA topoisomerase 1 topA 0.0009
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0009
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0009
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0009
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0009
1268 Neuropeptide S receptor NPSR1 0.0009
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0009
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0009
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0009
468 Cytochrome P450 4A11 CYP4A11 0.0008
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0008
3639 Thymidine phosphorylase deoA 0.0008
3936 Thymidine phosphorylase TYMP 0.0008
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0008
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0008
3937 Fatty-acid amide hydrolase FAAH 0.0008
6073 Potassium channel subfamily K member 9 KCNK9 0.0008
6072 Potassium channel subfamily K member 3 KCNK3 0.0008
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0007
6042 Prostaglandin reductase 2 PTGR2 0.0007
5818 Folate receptor alpha FOLR1 0.0007
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0007
1792 Tissue-type plasminogen activator PLAT 0.0007
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0007
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0007
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0007
273 Apoptosis regulator Bcl-2 BCL2 0.0007
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0007
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0006
293 Gamma-glutamyl hydrolase GGH 0.0006
275 Arachidonate 5-lipoxygenase ALOX5 0.0006
1313 Lactoylglutathione lyase GLO1 0.0006
1650 Heme carrier protein 1 SLC46A1 0.0006
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0006
6743 Non-fluorescent flavoprotein luxF 0.0005
6753 Apolipoprotein M APOM 0.0005
2528 Fatty acid metabolism regulator protein fadR 0.0005
6740 Fatty acid metabolism regulator protein fadR 0.0005
6752 Guanylyl cyclase-activating protein 1 GUCA1A 0.0005
394 Calcineurin subunit B isoform 1 PPP3R1 0.0005
6742 Recoverin RCVRN 0.0005
6747 Chalcone/stilbene synthase family protein MT1417 0.0005
6741 Peroxisomal 3,2-trans-enoyl-CoA isomerase PECI 0.0005
6522 Hepatocyte nuclear factor 4-alpha HNF4A 0.0005
6751 Gag polyprotein gag 0.0005
6746 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform PPP3CA 0.0005
6749 Polyprotein Not Available 0.0005
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0005
5961 Insulin INS 0.0005
6527 Lymphocyte antigen 96 LY96 0.0005
6755 Poliovirus receptor PVR 0.0005
6020 Aldehyde oxidase AOX1 0.0004
6750 ADP-ribosylation factor 6 ARF6 0.0004
4373 Medium-chain-fatty-acid--CoA ligase Not Available 0.0004
6524 Protein tonB tonB 0.0004
365 Dihydrofolate reductase DHFR 0.0004
2381 Dihydrofolate reductase DFR1 0.0004
2833 Dihydrofolate reductase Not Available 0.0004
2931 Dihydrofolate reductase folA 0.0004
3544 Dihydrofolate reductase folA 0.0004
3682 Dihydrofolate reductase folA 0.0004
6642 Dihydrofolate reductase folA 0.0004
6756 Dihydrofolate reductase dfrA 0.0004
2616 Ganglioside GM2 activator GM2A 0.0004
2435 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase lpxC 0.0004
6613 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase lpxC 0.0004
2297 Genome polyprotein Not Available 0.0004
2322 Genome polyprotein Not Available 0.0004
2694 Genome polyprotein Not Available 0.0004
2719 Genome polyprotein Not Available 0.0004
2860 Genome polyprotein Not Available 0.0004
2928 Genome polyprotein Not Available 0.0004
3160 Genome polyprotein Not Available 0.0004
3260 Genome polyprotein Not Available 0.0004
4783 Genome polyprotein Not Available 0.0004
5726 Genome polyprotein Not Available 0.0004
5779 Genome polyprotein Not Available 0.0004
5867 Genome polyprotein Not Available 0.0004
6253 Genome polyprotein Not Available 0.0004
6301 Genome polyprotein Not Available 0.0004
6380 Genome polyprotein Not Available 0.0004
6381 Genome polyprotein Not Available 0.0004
6437 Genome polyprotein Not Available 0.0004
6520 Genome polyprotein Not Available 0.0004
6521 Genome polyprotein Not Available 0.0004
6652 Genome polyprotein Not Available 0.0004
6734 Genome polyprotein Not Available 0.0004
6735 Genome polyprotein Not Available 0.0004
6736 Genome polyprotein Not Available 0.0004
6737 Genome polyprotein Not Available 0.0004
6738 Genome polyprotein Not Available 0.0004
6739 Genome polyprotein Not Available 0.0004
6744 Genome polyprotein Not Available 0.0004
6748 Genome polyprotein Not Available 0.0004
6894 Genome polyprotein Not Available 0.0004
6898 Genome polyprotein Not Available 0.0004
6316 ADP-ribosylation factor 1 ARF1 0.0004
864 Gag-Pol polyprotein gag-pol 0.0003
2237 Gag-Pol polyprotein gag-pol 0.0003
2326 Gag-Pol polyprotein gag-pol 0.0003
2451 Gag-Pol polyprotein gag-pol 0.0003
2901 Gag-Pol polyprotein gag-pol 0.0003
3165 Gag-Pol polyprotein gag-pol 0.0003
3722 Gag-Pol polyprotein gag-pol 0.0003
6306 Gag-Pol polyprotein gag-pol 0.0003
6624 Gag-Pol polyprotein gag-pol 0.0003
4943 Cytochrome c6 petJ 0.0003
4954 Soluble cytochrome b558 Not Available 0.0003
4942 Diheme cytochrome c napB napB 0.0003
5000 HemO hemO 0.0003
4916 Cyanoglobin glbN 0.0003
4981 Iron-starvation protein PigA pigA 0.0003
4994 Hemoglobin-like protein HbO glbO 0.0003
4947 Bacterial hemoglobin vhb 0.0003
4975 Cytochrome c-556 RPA3973 0.0003
4935 Cytochrome c-554 cycA1 0.0003
4984 Neuroglobin NGB 0.0003
4934 Cytochrome c-551 nirM 0.0003
5218 Cytochrome c-551 nirM 0.0003
4961 Hemophore HasA hasA 0.0003
4905 Cytochrome c2 Not Available 0.0003
4939 Cytochrome c2 cycA 0.0003
4964 Cytochrome c2 cycA 0.0003
4979 Cytochrome c2 cycA 0.0003
6673 Cytochrome c2 cycA 0.0003
4910 Cytoglobin CYGB 0.0003
3116 Bacterioferritin bfr 0.0003
4906 Bacterioferritin bfr 0.0003
4965 Bacterioferritin bfr 0.0003
4936 Cytochrome c2 iso-2 Not Available 0.0003
4909 CooA protein cooA 0.0003
4915 Cytochrome c-550 psbV 0.0003
4959 Cytochrome c-550 psbV 0.0003
5216 Cytochrome c-550 psbV 0.0003
4925 Cytochrome c-type protein SHP shp 0.0003
4998 Hemoglobin-like protein yjbI yjbI 0.0003
4937 Cytochrome oxidase subunit II rcoxA 0.0003
644 Heme oxygenase 2 HMOX2 0.0003
4982 Heme oxygenase 2 pbsA2 0.0003
4903 Methyl-accepting chemotaxis protein Tar4 0.0003
4931 Cytochrome P450 167A1 CYP167A1 0.0003
4971 Nonaheme cytochrome c hmcA 0.0003
4989 Cytochrome c551 peroxidase ccp 0.0003
5222 Cytochrome c551 peroxidase ccpA 0.0003
4976 Apocytochrome f petA 0.0003
6407 Apocytochrome f petA 0.0003
4904 Cytochrome c family protein GSU1996 0.0003
4907 Cytochrome c-L moxG 0.0003
6865 Cytochrome c-L moxG 0.0003
4999 Cytochrome P450 165B3 CYP165B3 0.0003
4972 P450cin cinA 0.0003
4764 Cytochrome P450 165C4 CYP165C4 0.0003
4960 Putative cytochrome P450-family protein SCO7417 0.0003
4926 Heme-based aerotactic transducer hemAT hemAT 0.0003
4922 Cytochrome c, putative SO_4144 0.0003
4952 Catalase/peroxidase katA 0.0003
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0003
4993 Hydroxylamine oxidoreductase hao1 0.0003
3093 Catalase HPII katE 0.0003
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0003
2427 Ferrichrome-iron receptor fhuA 0.0003
6228 Nuclear receptor coactivator 1 NCOA1 0.0003
6264 cAMP-dependent protein kinase inhibitor alpha PKIA 0.0003
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0003
4920 Peroxidase/catalase katG 0.0002
4923 Cytochrome c3 DvMF_2499 0.0002
4945 Cytochrome c3 Not Available 0.0002
4949 Cytochrome c3 DVU_3171 0.0002
4968 Cytochrome c3 cytc3 0.0002
4997 Cytochrome c3 SO_2727 0.0002
5219 Cytochrome c3 cyd 0.0002
2119 Cytochrome b5 CYB5A 0.0002
4948 Cytochrome c-553 Not Available 0.0002
4902 Nine-heme cytochrome c Ddes_2038 0.0002
3189 High-molecular-weight cytochrome c hmcA 0.0002
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0002
4990 PpcA ppcA 0.0002
4037 Hypothetical protein GPX1 0.0002
4297 Hypothetical protein SP_1951 0.0002
4521 Hypothetical protein BC_2969 0.0002
4540 Hypothetical protein TM_1070 0.0002
4555 Hypothetical protein MT1739 0.0002
4569 Hypothetical protein mshD 0.0002
4578 Hypothetical protein PA3270 0.0002
4747 Hypothetical protein PA3967 0.0002
5177 Hypothetical protein TM_0096 0.0002
5194 Hypothetical protein PA1204 0.0002
5240 Hypothetical protein Rv2991 0.0002
5370 Hypothetical protein TM_1158 0.0002
5710 Hypothetical protein Tb927.5.1360 0.0002
4988 Sulfite oxidase, mitochondrial SUOX 0.0002
3375 Acidic cytochrome c3 Not Available 0.0002
3570 Cytochrome P450 152A1 cypC 0.0002
4289 Cytochrome P450 TT_P0059 0.0002
6262 Cytochrome P450 staP 0.0002
4992 Cytochrome c peroxidase Not Available 0.0002
2915 Sensor protein fixL fixL 0.0002
4944 Sensor protein fixL fixL 0.0002
4813 Heme oxygenase hmuO 0.0002
5769 Heme oxygenase Not Available 0.0002
4385 Cytochrome c' Not Available 0.0002
4967 Cytochrome c' cycA 0.0002
5038 Cytochrome c' Not Available 0.0002
5223 Cytochrome c' cycP 0.0002
2230 Catalase CAT 0.0002
3249 Catalase katA 0.0002
3625 Catalase katA 0.0002
4539 Catalase katA 0.0002
4941 Catalase katB 0.0002
3670 Soluble cytochrome b562 precursor cybC 0.0002
3411 Cytochrome P450 121 cyp121 0.0002
2617 Nitric oxide synthase oxygenase nos 0.0002
2701 Nitric oxide synthase oxygenase nos 0.0002
3291 Cytochrome c-552 cycA 0.0002
4927 Cytochrome c-552 nrfA 0.0002
4938 Cytochrome c-552 cycA 0.0002
4953 Cytochrome c-552 nrfA 0.0002
5217 Cytochrome c-552 cycM 0.0002
3102 Flavohemoprotein hmp 0.0002
4969 Flavohemoprotein hmp 0.0002
4386 Hemoglobin-like protein HbN glbN 0.0002
518 Peroxidase/catalase T katG 0.0002
3127 Nitrite reductase nirS 0.0002
3284 Nitrite reductase nirS 0.0002
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0002
3221 Cytochrome c4 cc4 0.0002
605 Fumarate reductase flavoprotein subunit frdA 0.0002
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0002
3673 Fumarate reductase flavoprotein subunit fccA 0.0002
4912 Fumarate reductase flavoprotein subunit ifcA 0.0002
6549 Fumarate reductase flavoprotein subunit frdA 0.0002
2972 6-deoxyerythronolide B hydroxylase eryF 0.0002
4608 Putative cytochrome P450 SCO1207 0.0002
4963 Putative cytochrome P450 SCO2884 0.0002
6254 Putative cytochrome P450 SCO6998 0.0002
260 Cytochrome P450 51 ERG11 0.0002
761 Cytochrome P450 51 ERG11 0.0002
3163 Cytochrome P450 51 cyp51 0.0002
358 Cystathionine beta-synthase CBS 0.0001
1507 Cytochrome c CYCS 0.0001
693 Hemoglobin subunit beta HBB 0.0001
6268 Hydroxyacid oxidase 1 HAO1 0.0001
810 Heme oxygenase 1 HMOX1 0.0001
3391 Heme oxygenase 1 pbsA1 0.0001
2298 Cytochrome P450-cam camC 0.0001
76 Nitric-oxide synthase, brain NOS1 0.0001
7 Nitric oxide synthase, inducible NOS2 0.0001
291 Nitric-oxide synthase, endothelial NOS3 0.0001
↑