DT-Web

DB08836 - Temocapril


Identification
Name Temocapril
Accession Number DB08836
Type small molecule
Description Temocapril is a prodrug-type angiotensin-I converting enzyme (ACE) inhibitor not approved for use in the United States, but is approved in Japan and South Korea. Temocapril can also be used in hemodialysis patients without risk of serious accumulation.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 513.07
Groups experimental
Monoisotopic Weight 512.120641135
Pharmacology
Indication Temocapril is an ACE inhibitor primarily indicated in the treatment of hypertension and congestive heart failure, diabetic nephropathy, and improvement of prognosis for coronary artery diseases (including acute myocardial infarction).
Mechanism of action Not Available
Absorption Temocapril is rapidly absorbed in the gastrointestinal tract and converted into the diacid (active) metabolite, which inhibits ACE in plasma.
Protein binding 99.5%, including those with renal impairment.
Biotransformation Not Available
Route of elimination Temocapril is eliminated primarily through the liver and kidneys.
Toxicity Not Available
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Angiotensin-converting enzyme
Name Angiotensin-converting enzyme
Gene Name ACE
Pharmacological action unknown
Actions inhibitor
References
  • Furuta S, Kiyosawa K, Higuchi M, Kasahara H, Saito H, Shioya H, Oguchi H: Pharmacokinetics of temocapril, an ACE inhibitor with preferential biliary excretion, in patients with impaired liver function. Eur J Clin Pharmacol. 1993;44(4):383-5. - Pubmed
DTHybrid score 0.5785

Transporters


Oligopeptide transporter, small intestine isoform
Name Oligopeptide transporter, small intestine isoform
Gene Name SLC15A1
Actions Not Available
References
  • Tsuji A: Transporter-mediated Drug Interactions. Drug Metab Pharmacokinet. 2002;17(4):253-74. - Pubmed
DTHybrid score 0.4666
Solute carrier organic anion transporter family member 1A2
Name Solute carrier organic anion transporter family member 1A2
Gene Name SLCO1A2
Actions Not Available
References
  • Ishizuka H, Konno K, Naganuma H, Nishimura K, Kouzuki H, Suzuki H, Stieger B, Meier PJ, Sugiyama Y: Transport of temocaprilat into rat hepatocytes: role of organic anion transporting polypeptide. J Pharmacol Exp Ther. 1998 Oct;287(1):37-42. - Pubmed
DTHybrid score 0.1853

Predictions


Id Partner name Gene Name Score
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.3255
1588 Multidrug resistance protein 1 ABCB1 0.0958
1385 Angiotensin-converting enzyme 2 ACE2 0.0827
1729 Solute carrier family 22 member 6 SLC22A6 0.0614
6142 Solute carrier family 22 member 8 SLC22A8 0.0479
633 Penicillin-binding proteins 1A/1B pbpA 0.0461
118 Organic cation/carnitine transporter 2 SLC22A5 0.0442
587 Serum albumin ALB 0.0438
294 Neprilysin MME 0.0432
4512 Cytochrome P450 3A4 CYP3A4 0.041
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.039
3923 Cholinesterase BCHE 0.0344
6143 Solute carrier family 22 member 7 SLC22A7 0.0305
4119 Cytochrome P450 2D6 CYP2D6 0.0277
4604 Liver carboxylesterase 1 CES1 0.0273
3917 Methylenetetrahydrofolate reductase MTHFR 0.0267
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.026
6141 Sodium/bile acid cotransporter SLC10A1 0.0259
6016 Cytochrome P450 2C19 CYP2C19 0.0254
4757 Cytochrome P450 2C9 CYP2C9 0.0246
4924 Cytochrome P450 2C8 CYP2C8 0.0241
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0237
776 Bile salt export pump ABCB11 0.0237
1 Peptidoglycan synthetase ftsI ftsI 0.0235
4155 Peptidoglycan synthetase ftsI ftsI 0.0235
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0234
6702 Organic hydroperoxide resistance protein, putative VC_A1006 0.0228
4587 Carbapenem-hydrolyzing beta-lactamase blaB-1 blaB1 0.0228
4586 FEZ-1 protein blaFEZ-1 0.0228
645 Penicillin-binding protein 1A mrcA 0.0221
5805 Penicillin-binding protein 1A ponA 0.0221
6185 Penicillin-binding protein 1A mrcA 0.0221
6799 Penicillin-binding protein 1A pbpA 0.0221
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0214
1024 Solute carrier family 22 member 11 SLC22A11 0.0201
4118 Cytochrome P450 3A5 CYP3A5 0.0186
543 Penicillin-binding protein 1B mrcB 0.0174
6186 Penicillin-binding protein 1B ponB 0.0174
6822 Penicillin-binding protein 1b pbp1b 0.0174
6844 Penicillin-binding protein 1b pbp1b 0.0174
2164 Multidrug resistance-associated protein 4 ABCC4 0.0172
862 Multidrug resistance-associated protein 1 ABCC1 0.0172
33 Cystine/glutamate transporter SLC7A11 0.017
707 72 kDa type IV collagenase MMP2 0.0167
471 Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) SLC6A14 0.0166
6107 Cytochrome P450 3A7 CYP3A7 0.0164
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0162
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0147
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0146
5754 Metallo-beta-lactamase L1 Not Available 0.0143
2998 Sialic acid-binding Ig-like lectin 7 SIGLEC7 0.0142
3626 Probable polysaccharide deacetylase pdaA pdaA 0.0138
6145 Solute carrier family 22 member 1 SLC22A1 0.0137
65 Matrix metalloproteinase-9 Not Available 0.0135
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0134
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0127
4787 Envelope glycoprotein gp160 env 0.0125
4820 Envelope glycoprotein gp160 env 0.0125
5727 Envelope glycoprotein gp160 env 0.0125
3587 Gastrotropin FABP6 0.0117
904 Glutathione S-transferase P GSTP1 0.0116
1373 Glucosylceramidase GBA 0.0114
4666 Fucose-binding lectin PA-IIL lecB 0.0114
6030 Cytochrome P450 2B6 CYP2B6 0.0114
1757 Myeloperoxidase MPO 0.0112
4200 Cytochrome P450 1A2 CYP1A2 0.0109
115 Penicillin-binding protein 2 mrdA 0.0108
6069 Penicillin-binding protein 2 mrdA 0.0108
6118 Penicillin-binding protein 2 penA 0.0108
6187 Penicillin-binding protein 2 pbpA 0.0108
6686 Penicillin-binding protein 2 pbp2 0.0108
6939 Penicillin-binding protein 2 mrdA 0.0108
7163 Penicillin-binding protein 2 pbpA 0.0108
6067 Penicillin binding protein 2a mecA 0.0107
56 Delta-aminolevulinic acid dehydratase ALAD 0.0106
2356 Delta-aminolevulinic acid dehydratase hemB 0.0106
3613 Delta-aminolevulinic acid dehydratase hemB 0.0106
3674 Delta-aminolevulinic acid dehydratase hemB 0.0106
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0104
3140 Hemagglutinin-neuraminidase HN 0.0104
3609 Hemagglutinin-neuraminidase HN 0.0104
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0101
3810 Catechol O-methyltransferase COMT 0.0101
738 Monocarboxylate transporter 1 SLC16A1 0.0099
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0097
3671 7-alpha-hydroxysteroid dehydrogenase hdhA 0.0096
136 Estrogen receptor ESR1 0.0092
2544 Bacterial leucyl aminopeptidase Not Available 0.0092
871 Glucocorticoid receptor NR3C1 0.0088
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0088
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0087
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0087
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0087
6024 Cytochrome P450 1A1 CYP1A1 0.0086
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0084
6113 MecA PBP2' (penicillin binding protein 2') mecA 0.0082
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0081
20 Prostaglandin G/H synthase 1 PTGS1 0.008
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0077
737 Mineralocorticoid receptor NR3C2 0.0076
4785 Ig gamma-1 chain C region IGHG1 0.0074
756 Sex hormone-binding globulin SHBG 0.0074
318 Alpha-2A adrenergic receptor ADRA2A 0.0071
833 Organic cation/carnitine transporter 1 SLC22A4 0.007
3060 Leukotriene A-4 hydrolase LTA4H 0.0069
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0069
1141 Sialidase-1 NEU1 0.0068
64 Neuraminidase NA 0.0068
641 Neuraminidase NA 0.0068
2676 Neuraminidase NA 0.0068
3026 Neuraminidase NA 0.0068
3519 Neuraminidase NA 0.0068
6007 Neuraminidase NA 0.0068
731 HIV-1 protease HIV-1 protease 0.0067
6013 Cytochrome P450 2E1 CYP2E1 0.0066
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0064
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0064
146 Androgen receptor AR 0.0064
869 Estrogen receptor beta ESR2 0.0064
290 Prostaglandin G/H synthase 2 PTGS2 0.0062
594 Thyroxine-binding globulin SERPINA7 0.006
6167 Organic solute transporter subunit beta OSTB 0.006
6166 Organic solute transporter subunit alpha OSTA 0.006
474 Acetylcholinesterase ACHE 0.006
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0059
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0058
159 Penicillin-binding protein 2B penA 0.0056
6121 Penicillin-binding protein 2B penA 0.0056
632 Alpha-1B adrenergic receptor ADRA1B 0.0056
758 Thyroid hormone receptor alpha THRA 0.0056
4252 Penicillin-binding protein 5 dacA 0.0054
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0053
5482 Sialidase-2 NEU2 0.0052
380 Cytochrome P450 17A1 CYP17A1 0.0051
5718 Cytochrome P450 2A6 CYP2A6 0.0051
6144 Solute carrier family 22 member 2 SLC22A2 0.005
346 Thyroid hormone receptor beta-1 THRB 0.005
556 Alpha-1A adrenergic receptor ADRA1A 0.005
3811 Cytochrome P450 19A1 CYP19A1 0.0049
6106 Cytochrome P450 2C18 CYP2C18 0.0047
332 Beta-lactamase blaZ 0.0047
2478 Beta-lactamase ampC 0.0047
2613 Beta-lactamase ampC 0.0047
2635 Beta-lactamase ampC 0.0047
2700 Beta-lactamase penP 0.0047
5445 Beta-lactamase blaB 0.0047
6019 Beta-lactamase SHV-7 0.0047
6701 Beta-lactamase cphA 0.0047
509 Thymidine kinase TK 0.0046
570 Thymidine kinase TK 0.0046
2559 Thymidine kinase TK 0.0046
3430 Thymidine kinase tdk 0.0046
3518 Thymidine kinase TK 0.0046
5301 Thymidine kinase tdk 0.0046
5771 Thymidine kinase ORF36 0.0046
7009 Thymidine kinase ORF36 0.0046
6151 Monocarboxylate transporter 10 SLC16A10 0.0046
1898 Cytochrome P450 1B1 CYP1B1 0.0046
341 5-hydroxytryptamine 3 receptor HTR3A 0.0046
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0044
3760 Penicillin-binding protein 5 precursor dacA 0.0042
6148 Multidrug resistance-associated protein 7 ABCC10 0.0042
469 Annexin A1 ANXA1 0.0042
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0041
3426 Glutamine synthetase glnA 0.0041
3987 Glutamine synthetase GLUL 0.0041
338 DNA polymerase UL30 0.004
379 DNA polymerase UL54 0.004
697 DNA polymerase ORF28 0.004
2482 DNA polymerase 43 0.004
4104 DNA polymerase BALF5 0.004
6184 D-alanyl-D-alanine carboxypeptidase dacC dacC 0.004
232 Corticosteroid-binding globulin SERPINA6 0.004
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0039
867 Penicillin-binding protein 3 pbpC 0.0038
6119 Penicillin-binding protein 3 pbp3 0.0038
7154 Penicillin-binding protein 3 pbp3 0.0038
7157 Penicillin-binding protein 3 LMHCC_2184 0.0038
7162 Penicillin-binding protein 3 pbpB 0.0038
7172 Penicillin-binding protein 3 pbp3 0.0038
373 Transthyretin TTR 0.0038
6136 Multidrug resistance-associated protein 5 ABCC5 0.0037
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0036
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0036
468 Cytochrome P450 4A11 CYP4A11 0.0035
4238 50S ribosomal protein L4 rplD 0.0035
5578 50S ribosomal protein L4 rplD 0.0035
6173 50S ribosomal protein L4 rplD 0.0035
6219 50S ribosomal protein L4 rplD 0.0035
1517 Beta-3 adrenergic receptor ADRB3 0.0034
199 Monocarboxylate transporter 8 SLC16A2 0.0034
6033 High affinity interleukin-8 receptor A CXCR1 0.0034
511 5-hydroxytryptamine 1F receptor HTR1F 0.0033
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0033
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0033
1291 cAMP response element-binding protein CREB1 0.0032
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0032
4237 50S ribosomal protein L22 rplV 0.0032
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0032
4210 Toll-like receptor 4 TLR4 0.0032
3941 Amine oxidase [flavin-containing] A MAOA 0.0031
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0031
132 ATP-binding cassette sub-family A member 1 ABCA1 0.003
6031 Cytochrome P450 3A43 CYP3A43 0.0029
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0029
663 Solute carrier family 12 member 4 SLC12A4 0.0029
53 Solute carrier family 12 member 5 SLC12A5 0.0029
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0027
310 Solute carrier family 12 member 2 SLC12A2 0.0027
6149 Solute carrier family 22 member 10 SLC22A10 0.0026
492 Histamine H1 receptor HRH1 0.0025
1630 Integrin beta-2 ITGB2 0.0024
163 D(1B) dopamine receptor DRD5 0.0024
725 5-hydroxytryptamine 1D receptor HTR1D 0.0024
885 5-hydroxytryptamine 1B receptor HTR1B 0.0024
976 Platelet glycoprotein IX GP9 0.0023
432 D(4) dopamine receptor DRD4 0.0023
638 D(3) dopamine receptor DRD3 0.0022
6085 Fatty acid-binding protein, intestinal FABP2 0.0022
2461 D-alanyl-D-alanine carboxypeptidase Not Available 0.0021
5756 D-alanyl-D-alanine carboxypeptidase dac 0.0021
320 5-hydroxytryptamine 1A receptor HTR1A 0.0021
558 Solute carrier family 12 member 1 SLC12A1 0.002
23 D(1A) dopamine receptor DRD1 0.002
6044 Serum paraoxonase/lactonase 3 PON3 0.002
467 Delta-type opioid receptor OPRD1 0.0019
696 Kappa-type opioid receptor OPRK1 0.0019
6137 Multidrug resistance-associated protein 6 ABCC6 0.0019
2021 Thrombomodulin THBD 0.0018
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0018
831 D(2) dopamine receptor DRD2 0.0018
847 Mu-type opioid receptor OPRM1 0.0018
572 Integrin alpha-L ITGAL 0.0018
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0018
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0018
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0017
4122 Histone deacetylase 2 HDAC2 0.0016
5934 Cytochrome P450 26A1 CYP26A1 0.0015
6218 Pannexin-1 PANX1 0.0015
751 Potassium channel subfamily K member 6 KCNK6 0.0015
6147 Solute carrier family 22 member 3 SLC22A3 0.0015
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0015
1010 Cytochrome P450 51A1 CYP51A1 0.0015
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0015
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0014
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0014
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0014
84 Nuclear receptor 0B1 NR0B1 0.0014
172 Potassium channel subfamily K member 1 KCNK1 0.0014
6042 Prostaglandin reductase 2 PTGR2 0.0014
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0014
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0014
2391 Ferrochelatase hemH 0.0014
6502 Ferrochelatase DKFZp686P18130 0.0014
1591 Ferrochelatase, mitochondrial FECH 0.0014
5818 Folate receptor alpha FOLR1 0.0013
6220 Aryl hydrocarbon receptor AHR 0.0013
1792 Tissue-type plasminogen activator PLAT 0.0013
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0013
6043 Putative G-protein coupled receptor 44 GPR44 0.0012
273 Apoptosis regulator Bcl-2 BCL2 0.0012
6014 Cytochrome P450 2A13 CYP2A13 0.0012
260 Cytochrome P450 51 ERG11 0.0012
761 Cytochrome P450 51 ERG11 0.0012
3163 Cytochrome P450 51 cyp51 0.0012
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0012
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0012
284 DNA-directed RNA polymerase beta chain rpoB 0.0012
5773 DNA-directed RNA polymerase beta chain rpoB 0.0012
293 Gamma-glutamyl hydrolase GGH 0.0012
6493 Cytochrome c oxidase subunit 6C COX6C 0.0012
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0012
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0012
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0012
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0012
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0012
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0012
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0012
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0012
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0012
6559 Cytochrome c oxidase subunit 2 ctaC 0.0012
6669 Cytochrome c oxidase subunit 2 ctaC 0.0012
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0012
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0012
6558 Cytochrome c oxidase subunit 1 ctaD 0.0012
2540 Choloylglycine hydrolase cbh 0.0011
1313 Lactoylglutathione lyase GLO1 0.0011
1650 Heme carrier protein 1 SLC46A1 0.001
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.001
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.001
489 Monocarboxylate transporter 2 SLC16A7 0.001
2981 Phospholipase A2, membrane associated PLA2G2A 0.001
6501 Fatty acid-binding protein, liver FABP1 0.001
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0009
952 Dipeptidyl peptidase 4 DPP4 0.0009
3809 Estrogen-related receptor gamma ESRRG 0.0009
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0009
7 Nitric oxide synthase, inducible NOS2 0.0008
6500 Phospholipase A2 PLA2G1B 0.0008
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0008
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0008
6020 Aldehyde oxidase AOX1 0.0008
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0008
24 Thymidylate synthase TMP1 0.0008
359 Thymidylate synthase TYMS 0.0008
2626 Thymidylate synthase thyA 0.0008
2729 Thymidylate synthase thyA 0.0008
5352 Thymidylate synthase THYA 0.0008
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0008
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0007
365 Dihydrofolate reductase DHFR 0.0007
2381 Dihydrofolate reductase DFR1 0.0007
2833 Dihydrofolate reductase Not Available 0.0007
2931 Dihydrofolate reductase folA 0.0007
3544 Dihydrofolate reductase folA 0.0007
3682 Dihydrofolate reductase folA 0.0007
6642 Dihydrofolate reductase folA 0.0007
6756 Dihydrofolate reductase dfrA 0.0007
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0007
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0007
517 Alcohol dehydrogenase 1C ADH1C 0.0007
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0007
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0006
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0006
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0006
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0006
824 Sodium-dependent serotonin transporter SLC6A4 0.0005
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