DB06720 - Velaglucerase alfa
| Identification | |
|---|---|
| Name | Velaglucerase alfa |
| Accession Number | DB06720 |
| Type | biotech |
| Description | Velaglucerase alfa is a gene-activated human recombinant glucocerebrosidase used for the treatment of Type 1 Gaucher disease, caused by a deficiency of the lysosomal enzyme glucocerebrosidase. Additionally, Velaglucerase alfa has also been investigated for use in Type 3 Gaucher disease. |
| Structure |
|
| Categories (*) | |
| Molecular Weight | ~63 kDa |
| Groups | approved |
| Monoisotopic Weight | Not Available |
| Pharmacology | |
| Indication | Velaglucerase alfa is a hydrolytic lysosomal glucocerebroside-specific enzyme indicated for long-term enzyme replacement therapy for pediatric and adult patients with type 1 Gaucher disease. |
| Mechanism of action | Velaglucerase alfa catalyzes the hydrolysis of glucocerebroside, reducing the amount of accumulated glucocerebroside. |
| Absorption | Not Available |
| Protein binding | Not Available |
| Biotransformation | Not Available |
| Route of elimination | Not Available |
| Toxicity | Not Available |
| Affected organisms | Not Available |
| Interactions | |
| Drug Interactions | Not Available |
| Food Interactions | Not Available |
Targets
| Glucosylceramidase | |
|---|---|
| Name | Glucosylceramidase |
| Gene Name | GBA |
| Pharmacological action | unknown |
| Actions | Not Available |
| References |
|
| DTHybrid score | 1.1806 |
Predictions
| Id | Partner name | Gene Name | Score |
|---|---|---|---|
| 3942 | CDP-diacylglycerol--inositol 3-phosphatidyltransferase | CDIPT | 0.1405 |
| 3562 | 1-phosphatidylinositol phosphodiesterase | Not Available | 0.1222 |
| 5040 | 1-phosphatidylinositol phosphodiesterase | plcA | 0.1222 |
| 3626 | Probable polysaccharide deacetylase pdaA | pdaA | 0.0624 |
| 2998 | Sialic acid-binding Ig-like lectin 7 | SIGLEC7 | 0.0501 |
| 4666 | Fucose-binding lectin PA-IIL | lecB | 0.0474 |
| 3140 | Hemagglutinin-neuraminidase | HN | 0.0473 |
| 3609 | Hemagglutinin-neuraminidase | HN | 0.0473 |
| 4787 | Envelope glycoprotein gp160 | env | 0.0473 |
| 4820 | Envelope glycoprotein gp160 | env | 0.0473 |
| 5727 | Envelope glycoprotein gp160 | env | 0.0473 |
| 4785 | Ig gamma-1 chain C region | IGHG1 | 0.0324 |
| 244 | Angiotensin-converting enzyme | ACE | 0.0272 |
| 474 | Acetylcholinesterase | ACHE | 0.0254 |