DT-Web

DB00712 - Flurbiprofen


Identification
Name Flurbiprofen
Accession Number DB00712 (APRD00753)
Type small molecule
Description Flurbiprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic and analgesic activity. Oral formulations of flurbiprofen may be used for the symptomatic treatment of rheumatoid arthritis, osteoarthritis and anklylosing spondylitis. Flurbiprofen may also be used topically prior to ocular surgery to prevent or reduce intraoperative miosis. Flurbiprofen is structurally and pharmacologically related to fenoprofen, ibuprofen, and ketoprofen.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 244.2609
Groups approved
Monoisotopic Weight 244.089957865
Pharmacology
Indication Flurbiprofen tablets are indicated for the acute or long-term symptomatic treatment of rheumatoid arthritis, osteorarthritis and anklosing spondylitis. It may also be used to treat pain associated with dysmenorrhea and mild to moderate pain accompanied by inflammation (e.g. bursitis, tendonitis, soft tissue trauma). Topical ophthalmic formulations may be used pre-operatively to prevent intraoperative miosis.
Mechanism of action Similar to other NSAIAs, the anti-inflammatory effect of flurbiprofen occurs via reversible inhibition of cyclooxygenase (COX), the enzyme responsible for the conversion of arachidonic acid to prostaglandin G2 (PGG2) and PGG2 to prostaglandin H2 (PGH2) in the prostaglandin synthesis pathway. This effectively decreases the concentration of prostaglandins involved in inflammation, pain, swelling and fever. Flurbiprofen is a non-selective COX inhibitor and inhibits the activity of both COX-1 and -2. It is also one of the most potent NSAIAs in terms of prostaglandin inhibitory activity.
Absorption Fluribiprofen is rapidly and almost completely absorbed following oral administration. Peak plasma concentrations are reached 0.5 - 4 hours after oral administration.
Protein binding > 99% bound, primarily to albumin. Binds to a different primary binding site on albumin than anticoagulants, sulfonamides and phenytoin.
Biotransformation Hepatic. Cytochrome P450 2C9 plays an important role in the metabolism of flurbiprofen to its major metabolite, 4’-hydroxy-flurbiprofen. The 4’-hydroxy-flurbiprofen metabolite showed little anti-inflammatory activity in animal models of inflammation.
Route of elimination Flurbiprofen is poorly excreted into human milk. Following dosing with flurbiprofen, less than 3% of flurbiprofen is excreted unchanged in the urine, with about 70% of the dose eliminated in the urine as parent drug and metabolites. Renal elimination is a significant pathway of elimination of flurbiprofen metabolites.
Toxicity LD50=10 mg/kg (orally in dogs).

Selective COX-2 inhibitors have been associated with increased risk of serious cardiovascular events (e.g. myocardial infarction, stroke) in some patients. Current data is insufficient to assess the cardiovascular risk of flurbiprofen. Flurbiprofen may increase blood pressure and/or cause fluid retention and edema. Use caution in patients with fluid retention or heart failure. Risk of GI toxicity including bleeding, ulceration and perforation. Risk of direct renal injury, including renal papillary necrosis. Anaphylactoid and serious skin reactions (e.g. exfoliative dermatitis, Stevens-Johnson syndrome, toxic epidermal necrolysis) may occur. Common adverse events include abdominal pain, constipation, diarrhea, dyspepsia, flatulence, GI bleeding, GI perforation, nausea, peptic ulcer, vomiting, renal function abnormalities, anemia, dizziness, edema, liver function test abnormalities, headache, prolonged bleeding time, pruritus, rash, tinnitus.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Acenocoumarol The NSAID, flurbiprofen, may increase the anticoagulant effect of acenocoumarol.
Alendronate Increased risk of gastric toxicity
Anisindione The NSAID, flurbiprofen, may increase the anticoagulant effect anisindione.
Azilsartan medoxomil Increases toxicity of each. May deteriorate renal function, particularly in volume depleted or elderly patients. Decreases effects of azilsartan by antagonism.
Colesevelam Bile acid sequestrants may decrease the absorption of Nonsteroidal Anti-Inflammatory Agents. Monitor for decreased serum concentrations/therapeutic effects of nonsteroidal anti-inflammatory agents (NSAID) if coadministered with bile acid sequestrants. Separating the administration of doses by 2 or more hours may reduce (but not eliminate) the risk of interaction. The manufacturer of colesevelam recommends that drugs should be administered at least 1 hour before or 4 hours after colesevelam.
Cyclosporine Monitor for nephrotoxicity
Dicumarol The NSAID, flurbiprofen, may increase the anticoagulant effect of dicumarol.
Difluprednate NSAIDs may slow healing.
Eltrombopag Increases levels of Flurbiprofen via metabolism decrease. UDP-glucuronosyltransferase inhibition.
Ginkgo biloba Additive anticoagulant/antiplatelet effects may increase bleed risk. Concomitant therapy should be avoided.
Methotrexate The NSAID, flurbiprofen, may decrease the renal excretion of methotrexate. Increased risk of methotrexate toxicity.
Pralatrexate NSAIDs increase the risk of toxicity due to impairment of renal clearance of pralatrexate thus increasing exposure. Monitor for adverse effects or adjust dose of pralatrexate.
Tamoxifen Flurbiprofen may reduce clearance rate of Tamoxifen. Monitor for changes in therapeutic/adverse effects of Tamoxifen if Flurbiprofen is initiated, discontinued or dose changed.
Telmisartan Concomitant use of Telmisartan and Flurbiprofen may increase the risk of acute renal failure and hyperkalemia. Monitor renal function at the beginning and during treatment.
Timolol The NSAID, Flurbiprofen, may antagonize the antihypertensive effect of Timolol.
Tolbutamide Flurbiprofen, a strong CYP2C9 inhibitor, may decrease the metabolism and clearance of Tolbutamide, a CYP2C9 substrate. Consider alternate therapy or monitor for changes in Tolbutamide therapeutic and adverse effects if Flurbiprofen is initiated, discontinued or dose changed.
Torasemide Flurbiprofen, a strong CYP2C9 inhibitor, may increase the serum concentration of Torasemide, a CYP2C9 substrate, by decreasing Torasemide metabolism and clearance. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of Torasemide if Flurbiprofen is initiated, discontinued or dose changed.
Trandolapril The NSAID, Flurbiprofen, may reduce the antihypertensive effect of Trandolapril. Consider alternate therapy or monitor for changes in Trandolapril efficacy if Flurbiprofen is initiated, discontinued or dose changed.
Treprostinil The prostacyclin analogue, Treprostinil, may increase the risk of bleeding when combined with the NSAID, Flurbiprofen. Monitor for increased bleeding during concomitant thearpy.
Trimethoprim The strong CYP2C9 inhibitor, Flurbiprofen, may decrease the metabolism and clearance of Trimethoprim, a CYP2C9 substrate. Consider alternate therapy or monitor for changes in therapeutic and adverse effects of Trimethoprim if Flurbiprofen is initiated, discontinued or dose changed.
Voriconazole Flurbiprofen, a strong CYP2C9 inhibitor, may increase the serum concentration of voriconazole by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of voriconazole if flurbiprofen is initiated, discontinued or dose changed.
Warfarin Flurbiprofen, a strong CYP2C9 inhibitor, may decrease the metabolism of warfarin. The antiplatelet effect of flurbiprofen may also increase the bleed risk associated with warfarin. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of warfarin if flurbiprofen is initiated, discontinued or dose changed.
Food Interactions
  • Avoid alcohol.
  • Take with food to reduce gastric irritation.

Targets


Prostaglandin G/H synthase 1
Name Prostaglandin G/H synthase 1
Gene Name PTGS1
Pharmacological action unknown
Actions inhibitor
References
  • Rieke CJ, Mulichak AM, Garavito RM, Smith WL: The role of arginine 120 of human prostaglandin endoperoxide H synthase-2 in the interaction with fatty acid substrates and inhibitors. J Biol Chem. 1999 Jun 11;274(24):17109-14. - Pubmed
  • Hewett SJ, Uliasz TF, Vidwans AS, Hewett JA: Cyclooxygenase-2 contributes to N-methyl-D-aspartate-mediated neuronal cell death in primary cortical cell culture. J Pharmacol Exp Ther. 2000 May;293(2):417-25. - Pubmed
  • Kurahashi K, Shirahase H, Nakamura S, Tarumi T, Koshino Y, Wang AM, Nishihashi T, Shimizu Y: Nicotine-induced contraction in the rat coronary artery: possible involvement of the endothelium, reactive oxygen species and COX-1 metabolites. J Cardiovasc Pharmacol. 2001 Oct;38 Suppl 1:S21-5. - Pubmed
  • Klegeris A, McGeer PL: Cyclooxygenase and 5-lipoxygenase inhibitors protect against mononuclear phagocyte neurotoxicity. Neurobiol Aging. 2002 Sep-Oct;23(5):787-94. - Pubmed
  • Droge MJ, van Sorge AA, van Haeringen NJ, Quax WJ, Zaagsma J: Alternative splicing of cyclooxygenase-1 mRNA in the human iris. Ophthalmic Res. 2003 May-Jun;35(3):160-3. - Pubmed
  • Basselin M, Villacreses NE, Lee HJ, Bell JM, Rapoport SI: Flurbiprofen, a cyclooxygenase inhibitor, reduces the brain arachidonic acid signal in response to the cholinergic muscarinic agonist, arecoline, in awake rats. Neurochem Res. 2007 Nov;32(11):1857-67. Epub 2007 Jun 12. - Pubmed
  • Nivsarkar M, Banerjee A, Padh H: Cyclooxygenase inhibitors: a novel direction for Alzheimer's management. Pharmacol Rep. 2008 Sep-Oct;60(5):692-8. - Pubmed
DTHybrid score 0.751
Prostaglandin G/H synthase 2
Name Prostaglandin G/H synthase 2
Gene Name PTGS2
Pharmacological action yes
Actions inhibitor
References
  • Bayly CI, Black WC, Leger S, Ouimet N, Ouellet M, Percival MD: Structure-based design of COX-2 selectivity into flurbiprofen. Bioorg Med Chem Lett. 1999 Feb 8;9(3):307-12. - Pubmed
  • van Haeringen NJ, van Sorge AA, Carballosa Core-Bodelier VM: Constitutive cyclooxygenase-1 and induced cyclooxygenase-2 in isolated human iris inhibited by S(+) flurbiprofen. J Ocul Pharmacol Ther. 2000 Aug;16(4):353-61. - Pubmed
  • Smith T, McCracken J, Shin YK, DeWitt D: Arachidonic acid and nonsteroidal anti-inflammatory drugs induce conformational changes in the human prostaglandin endoperoxide H2 synthase-2 (cyclooxygenase-2). J Biol Chem. 2000 Dec 22;275(51):40407-15. - Pubmed
  • Hinz B, Brune K, Rau T, Pahl A: Flurbiprofen enantiomers inhibit inducible nitric oxide synthase expression in RAW 264.7 macrophages. Pharm Res. 2001 Feb;18(2):151-6. - Pubmed
  • Hewett SJ, Uliasz TF, Vidwans AS, Hewett JA: Cyclooxygenase-2 contributes to N-methyl-D-aspartate-mediated neuronal cell death in primary cortical cell culture. J Pharmacol Exp Ther. 2000 May;293(2):417-25. - Pubmed
  • Basselin M, Villacreses NE, Lee HJ, Bell JM, Rapoport SI: Flurbiprofen, a cyclooxygenase inhibitor, reduces the brain arachidonic acid signal in response to the cholinergic muscarinic agonist, arecoline, in awake rats. Neurochem Res. 2007 Nov;32(11):1857-67. Epub 2007 Jun 12. - Pubmed
  • Nivsarkar M, Banerjee A, Padh H: Cyclooxygenase inhibitors: a novel direction for Alzheimer's management. Pharmacol Rep. 2008 Sep-Oct;60(5):692-8. - Pubmed
DTHybrid score 0.6671

Enzymes


Cytochrome P450 2C9
Name Cytochrome P450 2C9
Gene Name CYP2C9
Actions substrate
References
  • Mo SL, Zhou ZW, Yang LP, Wei MQ, Zhou SF: New insights into the structural features and functional relevance of human cytochrome P450 2C9. Part I. Curr Drug Metab. 2009 Dec;10(10):1075-126. - Pubmed
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
  • Lin Y, Lu P, Tang C, Mei Q, Sandig G, Rodrigues AD, Rushmore TH, Shou M: Substrate inhibition kinetics for cytochrome P450-catalyzed reactions. Drug Metab Dispos. 2001 Apr;29(4 Pt 1):368-74. - Pubmed
DTHybrid score 0.5016
UDP-glucuronosyltransferase 2B7
Name UDP-glucuronosyltransferase 2B7
Gene Name UGT2B7
Actions substrate
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
DTHybrid score 0.3876
UDP-glucuronosyltransferase 1-1
Name UDP-glucuronosyltransferase 1-1
Gene Name UGT1A1
Actions substrate
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
DTHybrid score 0.3626
UDP-glucuronosyltransferase 1-3
Name UDP-glucuronosyltransferase 1-3
Gene Name UGT1A3
Actions substrate
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
DTHybrid score 0.3182
UDP-glucuronosyltransferase 1-9
Name UDP-glucuronosyltransferase 1-9
Gene Name UGT1A9
Actions substrate
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
DTHybrid score 0.4061
UDP-glucuronosyltransferase 2B4
Name UDP-glucuronosyltransferase 2B4
Gene Name UGT2B4
Actions substrate
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
DTHybrid score 0.2291

Transporters


Multidrug resistance-associated protein 4
Name Multidrug resistance-associated protein 4
Gene Name ABCC4
Actions inhibitor
References
  • Reid G, Wielinga P, Zelcer N, van der Heijden I, Kuil A, de Haas M, Wijnholds J, Borst P: The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs. Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9244-9. Epub 2003 Jun 30. - Pubmed
DTHybrid score 0.2361
Solute carrier family 22 member 6
Name Solute carrier family 22 member 6
Gene Name SLC22A6
Actions inhibitor
References
  • Mulato AS, Ho ES, Cihlar T: Nonsteroidal anti-inflammatory drugs efficiently reduce the transport and cytotoxicity of adefovir mediated by the human renal organic anion transporter 1. J Pharmacol Exp Ther. 2000 Oct;295(1):10-5. - Pubmed
  • Apiwattanakul N, Sekine T, Chairoungdua A, Kanai Y, Nakajima N, Sophasan S, Endou H: Transport properties of nonsteroidal anti-inflammatory drugs by organic anion transporter 1 expressed in Xenopus laevis oocytes. Mol Pharmacol. 1999 May;55(5):847-54. - Pubmed
DTHybrid score 0.4154

Carriers


Multidrug resistance-associated protein 4
Name Multidrug resistance-associated protein 4
Gene Name ABCC4
Actions
References Not Available
DTHybrid score 0.2361
Solute carrier family 22 member 6
Name Solute carrier family 22 member 6
Gene Name SLC22A6
Actions
References Not Available
DTHybrid score 0.4154

Predictions


Id Partner name Gene Name Score
4512 Cytochrome P450 3A4 CYP3A4 0.3248
4924 Cytochrome P450 2C8 CYP2C8 0.2747
1588 Multidrug resistance protein 1 ABCB1 0.2366
6016 Cytochrome P450 2C19 CYP2C19 0.2293
4200 Cytochrome P450 1A2 CYP1A2 0.1901
4119 Cytochrome P450 2D6 CYP2D6 0.1651
6142 Solute carrier family 22 member 8 SLC22A8 0.149
4118 Cytochrome P450 3A5 CYP3A5 0.1355
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.1342
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.1213
1024 Solute carrier family 22 member 11 SLC22A11 0.1114
6030 Cytochrome P450 2B6 CYP2B6 0.1044
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0953
6107 Cytochrome P450 3A7 CYP3A7 0.0943
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0907
238 Peroxisome proliferator-activated receptor gamma PPARG 0.085
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.084
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0826
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0824
6013 Cytochrome P450 2E1 CYP2E1 0.0803
862 Multidrug resistance-associated protein 1 ABCC1 0.0798
6143 Solute carrier family 22 member 7 SLC22A7 0.0776
5718 Cytochrome P450 2A6 CYP2A6 0.0719
696 Kappa-type opioid receptor OPRK1 0.0707
467 Delta-type opioid receptor OPRD1 0.0698
847 Mu-type opioid receptor OPRM1 0.0679
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0666
6024 Cytochrome P450 1A1 CYP1A1 0.0652
275 Arachidonate 5-lipoxygenase ALOX5 0.0636
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0619
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0594
6136 Multidrug resistance-associated protein 5 ABCC5 0.0548
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0545
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0523
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0487
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0487
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0487
6145 Solute carrier family 22 member 1 SLC22A1 0.0454
6106 Cytochrome P450 2C18 CYP2C18 0.0446
4604 Liver carboxylesterase 1 CES1 0.0439
70 Type-1 angiotensin II receptor AGTR1 0.0429
1757 Myeloperoxidase MPO 0.0425
738 Monocarboxylate transporter 1 SLC16A1 0.0416
3810 Catechol O-methyltransferase COMT 0.0414
6102 Arylamine N-acetyltransferase 2 NAT2 0.0408
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0402
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0401
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0399
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0381
891 Dihydropteroate synthase folP 0.0378
5359 Dihydropteroate synthase folP 0.0378
7175 Dihydropteroate synthase sulI 0.0378
6085 Fatty acid-binding protein, intestinal FABP2 0.0376
2021 Thrombomodulin THBD 0.0364
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0357
6141 Sodium/bile acid cotransporter SLC10A1 0.0348
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0338
723 Cytosolic phospholipase A2 PLA2G4A 0.0323
118 Organic cation/carnitine transporter 2 SLC22A5 0.031
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0305
5880 Thrombopoietin receptor MPL 0.0303
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0299
776 Bile salt export pump ABCB11 0.0294
373 Transthyretin TTR 0.029
146 Androgen receptor AR 0.0274
6026 Alcohol dehydrogenase 6 ADH6 0.0266
459 Retinoic acid receptor RXR-alpha RXRA 0.0265
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0264
4164 Potassium voltage-gated channel subfamily KQT member 5 KCNQ5 0.0256
4163 Potassium voltage-gated channel subfamily KQT member 4 KCNQ4 0.0256
6012 Tryptophan 2,3-dioxygenase TDO2 0.0251
1792 Tissue-type plasminogen activator PLAT 0.0249
273 Apoptosis regulator Bcl-2 BCL2 0.0248
87 Hypoxanthine-guanine phosphoribosyltransferase HPRT1 0.0236
26 Vascular endothelial growth factor receptor 3 FLT4 0.0233
6144 Solute carrier family 22 member 2 SLC22A2 0.023
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0227
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0227
32 Vascular endothelial growth factor receptor 1 FLT1 0.0223
504 Mast/stem cell growth factor receptor KIT 0.0221
3923 Cholinesterase BCHE 0.0219
492 Histamine H1 receptor HRH1 0.0219
6137 Multidrug resistance-associated protein 6 ABCC6 0.0218
3312 Fatty acid-binding protein, brain FABP7 0.0217
6043 Putative G-protein coupled receptor 44 GPR44 0.0214
502 5-hydroxytryptamine 2A receptor HTR2A 0.0213
6220 Aryl hydrocarbon receptor AHR 0.021
6148 Multidrug resistance-associated protein 7 ABCC10 0.0208
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0206
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0206
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0201
645 Penicillin-binding protein 1A mrcA 0.0199
5805 Penicillin-binding protein 1A ponA 0.0199
6185 Penicillin-binding protein 1A mrcA 0.0199
6799 Penicillin-binding protein 1A pbpA 0.0199
5626 Nucleoside diphosphate kinase B NME2 0.0199
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0198
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0197
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0197
3811 Cytochrome P450 19A1 CYP19A1 0.0196
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0195
4132 Chloride channel protein ClC-Ka CLCNKA 0.0194
407 Vascular endothelial growth factor receptor 2 KDR 0.0194
24 Thymidylate synthase TMP1 0.019
359 Thymidylate synthase TYMS 0.019
2626 Thymidylate synthase thyA 0.019
2729 Thymidylate synthase thyA 0.019
5352 Thymidylate synthase THYA 0.019
3866 Serum amyloid A protein SAA1 0.019
1200 AMBP protein AMBP 0.019
1932 Apolipoprotein E APOE 0.019
1898 Cytochrome P450 1B1 CYP1B1 0.0189
1159 Interleukin-6 IL6 0.0185
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0185
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0184
811 Translocator protein TSPO 0.0184
817 DNA topoisomerase 2-alpha TOP2A 0.0183
228 Beta platelet-derived growth factor receptor PDGFRB 0.0181
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0181
2981 Phospholipase A2, membrane associated PLA2G2A 0.0178
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0178
543 Penicillin-binding protein 1B mrcB 0.0177
6186 Penicillin-binding protein 1B ponB 0.0177
6822 Penicillin-binding protein 1b pbp1b 0.0177
6844 Penicillin-binding protein 1b pbp1b 0.0177
6147 Solute carrier family 22 member 3 SLC22A3 0.0176
592 Carbonic anhydrase 4 CA4 0.0176
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0174
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0174
1760 Aminopeptidase N ANPEP 0.0173
6843 Aminopeptidase N pepN 0.0173
824 Sodium-dependent serotonin transporter SLC6A4 0.0173
633 Penicillin-binding proteins 1A/1B pbpA 0.0173
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0171
117 Sterol O-acyltransferase 1 SOAT1 0.017
295 Carbonic anhydrase 1 CA1 0.017
1389 Transforming growth factor beta-1 TGFB1 0.0169
1648 Elastin ELN 0.0169
558 Solute carrier family 12 member 1 SLC12A1 0.0167
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0162
5294 Nucleoside diphosphate kinase A NME1 0.0159
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0157
3233 Bile acid receptor NR1H4 0.0156
6033 High affinity interleukin-8 receptor A CXCR1 0.0155
672 Prostaglandin F2-alpha receptor PTGFR 0.0155
3639 Thymidine phosphorylase deoA 0.0153
3936 Thymidine phosphorylase TYMP 0.0153
357 Carbonic anhydrase 2 CA2 0.0151
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0149
588 Chromodomain-helicase-DNA-binding protein 1 CHD1 0.0144
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0144
489 Monocarboxylate transporter 2 SLC16A7 0.0143
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0143
6541 Peptostreptococcal albumin-binding protein pab 0.0142
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0142
5849 cAMP-dependent protein kinase type I-alpha regulatory subunit PRKAR1A 0.0142
1630 Integrin beta-2 ITGB2 0.0141
6149 Solute carrier family 22 member 10 SLC22A10 0.0141
404 DNA gyrase subunit A gyrA 0.0139
6224 DNA gyrase subunit A gyrA 0.0139
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0139
6103 Arylamine N-acetyltransferase 1 NAT1 0.0139
1 Peptidoglycan synthetase ftsI ftsI 0.0138
4155 Peptidoglycan synthetase ftsI ftsI 0.0138
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0137
341 5-hydroxytryptamine 3 receptor HTR3A 0.0136
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0135
777 Tumor necrosis factor TNF 0.0135
54 Prothrombin F2 0.0135
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0134
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0134
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0133
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0132
703 NADPH azoreductase azr 0.0132
1507 Cytochrome c CYCS 0.0132
6500 Phospholipase A2 PLA2G1B 0.0131
267 Plasminogen activator inhibitor 1 SERPINE1 0.0131
6042 Prostaglandin reductase 2 PTGR2 0.0131
556 Alpha-1A adrenergic receptor ADRA1A 0.0131
831 D(2) dopamine receptor DRD2 0.0129
136 Estrogen receptor ESR1 0.0129
2320 Thymidine kinase, cytosolic TK1 0.0129
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0128
130 Prostacyclin synthase PTGIS 0.0127
1275 Estrogen sulfotransferase SULT1E1 0.0127
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0127
3917 Methylenetetrahydrofolate reductase MTHFR 0.0127
1650 Heme carrier protein 1 SLC46A1 0.0127
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0123
850 Vasopressin V1b receptor AVPR1B 0.0122
308 30S ribosomal protein S12 rpsL 0.0122
6704 30S ribosomal protein S12 rpsL 0.0122
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0121
632 Alpha-1B adrenergic receptor ADRA1B 0.0121
6221 Steroid hormone receptor ERR1 ESRRA 0.0121
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0121
590 5-hydroxytryptamine 2C receptor HTR2C 0.012
1629 Transcription factor AP-1 JUN 0.0118
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0116
3947 Xanthine dehydrogenase/oxidase XDH 0.0116
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0116
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0116
338 DNA polymerase UL30 0.0116
379 DNA polymerase UL54 0.0116
697 DNA polymerase ORF28 0.0116
2482 DNA polymerase 43 0.0116
4104 DNA polymerase BALF5 0.0116
115 Penicillin-binding protein 2 mrdA 0.0116
6069 Penicillin-binding protein 2 mrdA 0.0116
6118 Penicillin-binding protein 2 penA 0.0116
6187 Penicillin-binding protein 2 pbpA 0.0116
6686 Penicillin-binding protein 2 pbp2 0.0116
6939 Penicillin-binding protein 2 mrdA 0.0116
7163 Penicillin-binding protein 2 pbpA 0.0116
1039 Histone deacetylase 9 HDAC9 0.0116
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0115
3809 Estrogen-related receptor gamma ESRRG 0.0115
6044 Serum paraoxonase/lactonase 3 PON3 0.0114
1050 Bile salt sulfotransferase SULT2A1 0.0114
766 Beta-2 adrenergic receptor ADRB2 0.0114
853 Farnesyl pyrophosphate synthetase FDPS 0.0113
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0112
4790 Glycosyltransferase GtfA gtfA 0.011
1313 Lactoylglutathione lyase GLO1 0.0109
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0108
23 D(1A) dopamine receptor DRD1 0.0108
6126 Carbonic anhydrase 7 CA7 0.0107
185 Vasopressin V1a receptor AVPR1A 0.0107
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0107
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0106
572 Integrin alpha-L ITGAL 0.0106
2853 14 kDa fatty acid-binding protein Not Available 0.0105
322 Vasopressin V2 receptor AVPR2 0.0105
1192 Sulfotransferase 1A1 SULT1A1 0.0105
1405 Thiopurine S-methyltransferase TPMT 0.0105
4217 Telomerase reverse transcriptase TERT 0.0104
823 Fibroblast growth factor receptor 2 FGFR2 0.0104
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0104
6031 Cytochrome P450 3A43 CYP3A43 0.0104
33 Cystine/glutamate transporter SLC7A11 0.0103
183 Vascular endothelial growth factor A VEGFA 0.0103
6138 Multidrug resistance protein 3 ABCB4 0.0103
342 P protein [Includes: DNA-directed DNA polymerase P 0.0102
612 P protein [Includes: DNA-directed DNA polymerase P 0.0102
319 Opioid receptor, sigma 1 OPRS1 0.0102
4122 Histone deacetylase 2 HDAC2 0.0102
122 P2Y purinoceptor 12 P2RY12 0.0101
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.01
165 FL cytokine receptor FLT3 0.01
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0099
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0099
1439 Lactotransferrin LTF 0.0098
2211 Fatty acid-binding protein, heart FABP3 0.0098
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0098
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0098
566 Serotransferrin TF 0.0094
789 Alpha-1D adrenergic receptor ADRA1D 0.0094
293 Gamma-glutamyl hydrolase GGH 0.0093
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0092
320 5-hydroxytryptamine 1A receptor HTR1A 0.0091
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0091
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.009
3685 Catabolite gene activator crp 0.0088
4655 Adenylate cyclase cyaC 0.0088
4759 Adenylate cyclase cyaB2 0.0088
756 Sex hormone-binding globulin SHBG 0.0087
844 Epidermal growth factor receptor EGFR 0.0087
1714 Mitogen-activated protein kinase 3 MAPK3 0.0087
782 ADP/ATP translocase 2 SLC25A5 0.0086
688 ADP/ATP translocase 3 SLC25A6 0.0086
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0086
1558 Transient receptor potential cation channel subfamily V member 1 TRPV1 0.0086
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0086
1198 Serum paraoxonase/arylesterase 1 PON1 0.0086
6223 Penicillin-binding protein 1C pbpC 0.0085
482 Glycine receptor subunit alpha-1 GLRA1 0.0085
2183 Fatty acid-binding protein, adipocyte FABP4 0.0084
2016 Dipeptidase 1 DPEP1 0.0082
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0081
833 Organic cation/carnitine transporter 1 SLC22A4 0.0081
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0081
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0081
1141 Sialidase-1 NEU1 0.008
64 Neuraminidase NA 0.008
641 Neuraminidase NA 0.008
2676 Neuraminidase NA 0.008
3026 Neuraminidase NA 0.008
3519 Neuraminidase NA 0.008
6007 Neuraminidase NA 0.008
6525 Group IID secretory phospholipase A2 PLA2G2D 0.008
1618 High affinity nerve growth factor receptor NTRK1 0.0079
61 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0079
2644 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0079
2710 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0079
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0077
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0076
4221 Vascular endothelial growth factor VEGF 0.0075
5816 Cadherin-5 CDH5 0.0075
6167 Organic solute transporter subunit beta OSTB 0.0075
6166 Organic solute transporter subunit alpha OSTA 0.0075
4760 Mll3241 protein mll3241 0.0075
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0074
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0074
1656 CYP2B protein CYP2B 0.0074
537 ATP synthase delta chain, mitochondrial ATP5D 0.0072
22 30S ribosomal protein S4 rpsD 0.0072
6714 30S ribosomal protein S4 rpsD 0.0072
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0072
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0072
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0072
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0072
3932 Glutathione S-transferase A2 GSTA2 0.0071
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0071
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0071
718 Folate receptor gamma FOLR3 0.0071
299 Folate receptor beta FOLR2 0.0071
804 Mitochondrial folate transporter/carrier SLC25A32 0.0071
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.007
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.007
908 Glutathione S-transferase theta-1 GSTT1 0.007
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0069
614 Progesterone receptor PGR 0.0069
3941 Amine oxidase [flavin-containing] A MAOA 0.0069
5787 Angiopoietin-1 receptor TEK 0.0068
140 30S ribosomal protein S9 rpsI 0.0068
6719 30S ribosomal protein S9 rpsI 0.0068
6725 30S ribosomal protein S9 rpsI 0.0068
1353 DNA topoisomerase 1 TOP1 0.0068
3552 DNA topoisomerase 1 topA 0.0068
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0068
705 Glutamate receptor 1 GRIA1 0.0067
952 Dipeptidyl peptidase 4 DPP4 0.0066
5798 Mitogen-activated protein kinase 11 MAPK11 0.0066
36 Insulin receptor INSR 0.0066
904 Glutathione S-transferase P GSTP1 0.0066
527 Prostacyclin receptor PTGIR 0.0066
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0066
661 ADP/ATP translocase 1 SLC25A4 0.0064
468 Cytochrome P450 4A11 CYP4A11 0.0064
477 DNA topoisomerase 4 subunit A parC 0.0064
886 DNA topoisomerase 4 subunit A parC 0.0064
6226 DNA topoisomerase 4 subunit A parC 0.0064
1119 Peroxiredoxin-5, mitochondrial PRDX5 0.0063
133 Dihydropterate synthase sulI 0.0063
5482 Sialidase-2 NEU2 0.0062
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0062
4116 Dihydropteroate synthetase Not Available 0.0062
822 Aldose reductase AKR1B1 0.0062
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0061
6184 D-alanyl-D-alanine carboxypeptidase dacC dacC 0.0061
889 3-oxoacyl-[acyl-carrier-protein] synthase 1 fabB 0.0061
6860 3-oxoacyl-[acyl-carrier-protein] synthase 1 kasA 0.0061
3823 Cytokine receptor common gamma chain IL2RG 0.0061
731 HIV-1 protease HIV-1 protease 0.006
3937 Fatty-acid amide hydrolase FAAH 0.006
134 Tryptophan 5-hydroxylase 1 TPH1 0.006
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.006
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.006
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.006
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.006
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0059
6014 Cytochrome P450 2A13 CYP2A13 0.0059
6020 Aldehyde oxidase AOX1 0.0059
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0059
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0057
759 Free fatty acid receptor 1 FFAR1 0.0056
1818 Long-chain-fatty-acid--CoA ligase 3 ACSL3 0.0056
4773 Deoxycytidine kinase DCK 0.0056
260 Cytochrome P450 51 ERG11 0.0056
761 Cytochrome P450 51 ERG11 0.0056
3163 Cytochrome P450 51 cyp51 0.0056
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0055
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0055
466 Solute carrier family 12 member 3 SLC12A3 0.0055
828 Phenylalanine-4-hydroxylase PAH 0.0054
3109 Phenylalanine-4-hydroxylase phhA 0.0054
6131 Carbonic anhydrase 14 CA14 0.0054
676 Tyrosine 3-monooxygenase TH 0.0054
4252 Penicillin-binding protein 5 dacA 0.0053
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0053
724 Interleukin-2 receptor alpha chain IL2RA 0.0053
717 Interleukin-2 receptor subunit beta IL2RB 0.0053
3808 Dihydropteroate synthase 2 folP2 0.0052
3601 Dihydropteroate synthase 1 folP1 0.0052
3807 Dihydropteroate synthase 1 folP1 0.0052
1867 Major prion protein PRNP 0.0052
159 Penicillin-binding protein 2B penA 0.0052
6121 Penicillin-binding protein 2B penA 0.0052
65 Matrix metalloproteinase-9 Not Available 0.0052
244 Angiotensin-converting enzyme ACE 0.0052
4752 Peroxisomal trans-2-enoyl-CoA reductase PECR 0.0052
2751 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0052
4755 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0052
737 Mineralocorticoid receptor NR3C2 0.0051
438 Taste receptor type 1 member 2 TAS1R2 0.0051
427 Substance-P receptor TACR1 0.0051
253 Sodium/potassium-transporting ATPase gamma chain FXYD2 0.0051
365 Dihydrofolate reductase DHFR 0.0051
2381 Dihydrofolate reductase DFR1 0.0051
2833 Dihydrofolate reductase Not Available 0.0051
2931 Dihydrofolate reductase folA 0.0051
3544 Dihydrofolate reductase folA 0.0051
3682 Dihydrofolate reductase folA 0.0051
6642 Dihydrofolate reductase folA 0.0051
6756 Dihydrofolate reductase dfrA 0.0051
4226 Uridine phosphorylase 2 UPP2 0.0051
936 Ephrin type-A receptor 2 EPHA2 0.005
3957 Adenosine deaminase ADA 0.005
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.005
871 Glucocorticoid receptor NR3C1 0.005
380 Cytochrome P450 17A1 CYP17A1 0.005
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.005
6027 Alkaline phosphatase, tissue-nonspecific isozyme ALPL 0.005
1053 BC269730_2 FADS1 0.0049
4192 DNA topoisomerase 2-beta TOP2B 0.0049
1395 Sodium/calcium exchanger 1 SLC8A1 0.0049
2236 Casein kinase II subunit alpha CSNK2A1 0.0049
869 Estrogen receptor beta ESR2 0.0049
277 Purine nucleoside phosphorylase PNP 0.0049
2870 Purine nucleoside phosphorylase punA 0.0049
2945 Purine nucleoside phosphorylase punA 0.0049
4659 Purine nucleoside phosphorylase TM_1596 0.0049
4825 Purine nucleoside phosphorylase TTHA1435 0.0049
819 Penicillin-binding protein 4 dacB 0.0048
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0048
6288 Low molecular weight phosphotyrosine protein phosphatase ACP1 0.0048
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0047
6832 Serine/threonine-protein kinase SRPK2 SRPK2 0.0046
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0046
4225 Uridine phosphorylase 1 UPP1 0.0046
3382 Glycolipid transfer protein GLTP 0.0046
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0046
707 72 kDa type IV collagenase MMP2 0.0046
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0046
7 Nitric oxide synthase, inducible NOS2 0.0046
4692 A/G-specific adenine glycosylase mutY 0.0046
3686 Acyl-CoA thioesterase I precursor tesA 0.0045
6207 30S ribosomal protein S14 rpsN 0.0045
6209 30S ribosomal protein S19 rpsS 0.0045
6712 30S ribosomal protein S19 rpsS 0.0045
6726 30S ribosomal protein S19 rpsS 0.0045
3760 Penicillin-binding protein 5 precursor dacA 0.0045
6339 Ig kappa chain V-II region RPMI 6410 Not Available 0.0044
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0044
6171 Solute carrier family 28 member 3 SLC28A3 0.0044
6218 Pannexin-1 PANX1 0.0044
465 Calmodulin CALM1 0.0044
291 Nitric-oxide synthase, endothelial NOS3 0.0044
713 Sodium-dependent dopamine transporter SLC6A3 0.0044
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0044
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0044
663 Solute carrier family 12 member 4 SLC12A4 0.0044
53 Solute carrier family 12 member 5 SLC12A5 0.0044
413 Amidophosphoribosyltransferase PPAT 0.0044
2515 Amidophosphoribosyltransferase purF 0.0044
3714 Amidophosphoribosyltransferase purF 0.0044
49 Endothelin B receptor EDNRB 0.0044
5645 DNA topoisomerase 4 subunit B parE 0.0044
6227 DNA topoisomerase 4 subunit B parE 0.0044
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0043
5698 Riboflavin synthase alpha chain ribE 0.0043
4606 Purine trans deoxyribosylase ptd 0.0042
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0042
887 DNA gyrase subunit B gyrB 0.0041
4150 DNA gyrase subunit B gyrB 0.0041
6225 DNA gyrase subunit B gyrB 0.0041
578 Endothelin-1 receptor EDNRA 0.0041
408 Riboflavin kinase RFK 0.0041
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0041
310 Solute carrier family 12 member 2 SLC12A2 0.0041
634 Squalene monooxygenase SQLE 0.0041
7196 Squalene monooxygenase ERG1 0.0041
3587 Gastrotropin FABP6 0.0041
3939 Amine oxidase [flavin-containing] B MAOB 0.0041
3679 MTA/SAH nucleosidase mtnN 0.004
1958 S-methyl-5-thioadenosine phosphorylase MTAP 0.004
318 Alpha-2A adrenergic receptor ADRA2A 0.004
6508 Putative uncharacterized protein srtB 0.004
6543 Putative uncharacterized protein tcp14 0.004
6615 Putative uncharacterized protein MT0785 0.004
6623 Putative uncharacterized protein Not Available 0.004
6806 Putative uncharacterized protein AGR_C_2535 0.004
6813 Putative uncharacterized protein SAV4671 0.004
6815 Putative uncharacterized protein AFE_1514 0.004
6819 Putative uncharacterized protein RUMGNA_03254 0.004
6825 Putative uncharacterized protein CV_3270 0.004
3426 Glutamine synthetase glnA 0.004
3987 Glutamine synthetase GLUL 0.004
4161 Furin FURIN 0.004
775 Acetyl-CoA carboxylase 2 ACACB 0.004
232 Corticosteroid-binding globulin SERPINA6 0.0039
702 UMP-CMP kinase CMPK1 0.0039
128 Adenine phosphoribosyltransferase APRT 0.0038
638 D(3) dopamine receptor DRD3 0.0038
6067 Penicillin binding protein 2a mecA 0.0038
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0038
780 Retinoic acid receptor RXR-gamma RXRG 0.0038
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0038
5353 Glutamate decarboxylase alpha gadA 0.0037
1789 Lymphotoxin-alpha LTA 0.0037
1269 Tumor necrosis factor receptor superfamily member 1B TNFRSF1B 0.0037
3856 Fibroblast growth factor receptor 3 FGFR3 0.0037
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0036
6146 High affinity copper uptake protein 1 SLC31A1 0.0036
2207 Rhodopsin RHO 0.0036
595 Fibrinogen alpha chain FGA 0.0036
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0036
5818 Folate receptor alpha FOLR1 0.0035
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0035
106 Cannabinoid receptor 2 CNR2 0.0035
436 5-hydroxytryptamine 2B receptor HTR2B 0.0035
88 Retinoic acid receptor RXR-beta RXRB 0.0035
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0034
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0034
6501 Fatty acid-binding protein, liver FABP1 0.0033
68 Cannabinoid receptor 1 CNR1 0.0033
2178 Metabotropic glutamate receptor 5 GRM5 0.0033
6122 Carbonic anhydrase 3 CA3 0.0033
332 Beta-lactamase blaZ 0.0033
2478 Beta-lactamase ampC 0.0033
2613 Beta-lactamase ampC 0.0033
2635 Beta-lactamase ampC 0.0033
2700 Beta-lactamase penP 0.0033
5445 Beta-lactamase blaB 0.0033
6019 Beta-lactamase SHV-7 0.0033
6701 Beta-lactamase cphA 0.0033
3007 Carbonic anhydrase 12 CA12 0.0033
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0033
4205 Carbonic anhydrase 9 CA9 0.0033
4784 Beta-mannosidase manB 0.0032
6695 Beta-mannosidase BT_0458 0.0032
594 Thyroxine-binding globulin SERPINA7 0.0032
6677 Myelin P2 protein PMP2 0.0032
1196 Complement decay-accelerating factor CD55 0.0032
1227 Cytochrome b MT-CYB 0.0031
6386 Cytochrome b petB 0.0031
6937 Cytochrome b MT-CYB 0.0031
674 Dihydroorotate dehydrogenase homolog, mitochondrial PFF0160c 0.0031
2264 Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase cobT 0.0031
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.003
758 Thyroid hormone receptor alpha THRA 0.003
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.003
654 Flavin reductase BLVRB 0.0029
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0029
3813 Fibrinogen gamma chain FGG 0.0029
3812 Fibrinogen beta chain [Contains: Fibrinopeptide B] FGB 0.0029
528 5-hydroxytryptamine 1E receptor HTR1E 0.0029
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0029
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0029
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0029
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0029
3688 Branched-chain-amino-acid aminotransferase ilvE 0.0028
2998 Sialic acid-binding Ig-like lectin 7 SIGLEC7 0.0028
2808 Chloramphenicol acetyltransferase 3 cat3 0.0028
1278 Pro-epidermal growth factor EGF 0.0028
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0027
1025 Aquaporin-1 AQP1 0.0027
885 5-hydroxytryptamine 1B receptor HTR1B 0.0027
346 Thyroid hormone receptor beta-1 THRB 0.0027
2159 Quinone oxidoreductase CRYZ 0.0027
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0027
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0027
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0027
1992 Vitamin D-binding protein GC 0.0027
571 Melatonin receptor type 1A MTNR1A 0.0026
362 Melatonin receptor type 1B MTNR1B 0.0026
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0026
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0026
1864 RET proto-oncogene RET 0.0026
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0025
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0025
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0025
2417 Chloramphenicol acetyltransferase cat 0.0025
3278 Chloramphenicol acetyltransferase cat 0.0025
509 Thymidine kinase TK 0.0025
570 Thymidine kinase TK 0.0025
2559 Thymidine kinase TK 0.0025
3430 Thymidine kinase tdk 0.0025
3518 Thymidine kinase TK 0.0025
5301 Thymidine kinase tdk 0.0025
5771 Thymidine kinase ORF36 0.0025
7009 Thymidine kinase ORF36 0.0025
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0025
716 5-hydroxytryptamine 7 receptor HTR7 0.0025
2810 Dr hemagglutinin structural subunit draA 0.0025
760 Fibroblast growth factor 1 FGF1 0.0025
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0025
4787 Envelope glycoprotein gp160 env 0.0025
4820 Envelope glycoprotein gp160 env 0.0025
5727 Envelope glycoprotein gp160 env 0.0025
1541 Metalloproteinase mmp20 0.0025
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0024
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0024
193 Beta-1 adrenergic receptor ADRB1 0.0024
3814 Complement C1r subcomponent C1R 0.0024
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0024
471 Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) SLC6A14 0.0024
2297 Genome polyprotein Not Available 0.0024
2322 Genome polyprotein Not Available 0.0024
2694 Genome polyprotein Not Available 0.0024
2719 Genome polyprotein Not Available 0.0024
2860 Genome polyprotein Not Available 0.0024
2928 Genome polyprotein Not Available 0.0024
3160 Genome polyprotein Not Available 0.0024
3260 Genome polyprotein Not Available 0.0024
4783 Genome polyprotein Not Available 0.0024
5726 Genome polyprotein Not Available 0.0024
5779 Genome polyprotein Not Available 0.0024
5867 Genome polyprotein Not Available 0.0024
6253 Genome polyprotein Not Available 0.0024
6301 Genome polyprotein Not Available 0.0024
6380 Genome polyprotein Not Available 0.0024
6381 Genome polyprotein Not Available 0.0024
6437 Genome polyprotein Not Available 0.0024
6520 Genome polyprotein Not Available 0.0024
6521 Genome polyprotein Not Available 0.0024
6652 Genome polyprotein Not Available 0.0024
6734 Genome polyprotein Not Available 0.0024
6735 Genome polyprotein Not Available 0.0024
6736 Genome polyprotein Not Available 0.0024
6737 Genome polyprotein Not Available 0.0024
6738 Genome polyprotein Not Available 0.0024
6739 Genome polyprotein Not Available 0.0024
6744 Genome polyprotein Not Available 0.0024
6748 Genome polyprotein Not Available 0.0024
6894 Genome polyprotein Not Available 0.0024
6898 Genome polyprotein Not Available 0.0024
6231 Pepsin A PGA3 0.0024
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0024
2249 Aspartate aminotransferase aspC 0.0023
2671 Aspartate aminotransferase aspC 0.0023
5490 Aspartate aminotransferase Not Available 0.0023
94 5-hydroxytryptamine 4 receptor HTR4 0.0023
4103 Proteasome subunit beta type 2 PSMB2 0.0023
4102 Proteasome subunit beta type 5 PSMB5 0.0023
4101 Proteasome subunit beta type 1 PSMB1 0.0023
6182 Cytochrome P450 2J2 CYP2J2 0.0023
5934 Cytochrome P450 26A1 CYP26A1 0.0023
921 Glutamate receptor 2 GRIA2 0.0023
629 Alpha-2B adrenergic receptor ADRA2B 0.0022
2782 Complement C1s subcomponent C1S 0.0022
1374 Natriuretic peptides B NPPB 0.0022
1525 Heparin-binding growth factor 2 FGF2 0.0022
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0022
1827 Gap junction alpha-1 protein GJA1 0.0022
1908 Vascular cell adhesion protein 1 VCAM1 0.0022
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0022
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0022
725 5-hydroxytryptamine 1D receptor HTR1D 0.0022
284 DNA-directed RNA polymerase beta chain rpoB 0.0022
5773 DNA-directed RNA polymerase beta chain rpoB 0.0022
3480 Mannan endo-1,4-beta-mannosidase manA 0.0022
2461 D-alanyl-D-alanine carboxypeptidase Not Available 0.0022
5756 D-alanyl-D-alanine carboxypeptidase dac 0.0022
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0021
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0021
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0021
3437 Eosinophil lysophospholipase CLC 0.0021
896 Glutathione S-transferase Mu 1 GSTM1 0.0021
4210 Toll-like receptor 4 TLR4 0.0021
4203 Histamine N-methyltransferase HNMT 0.0021
511 5-hydroxytryptamine 1F receptor HTR1F 0.0021
3817 Complement C1q subcomponent subunit C C1QC 0.0021
3815 Complement C1q subcomponent subunit A C1QA 0.0021
3816 Complement C1q subcomponent subunit B C1QB 0.0021
331 Retinol-binding protein I, cellular RBP1 0.0021
1102 Low affinity immunoglobulin gamma Fc region receptor III-B FCGR3B 0.0021
3818 Low affinity immunoglobulin gamma Fc region receptor III-A FCGR3A 0.0021
3819 Low affinity immunoglobulin gamma Fc region receptor II-a FCGR2A 0.0021
3821 Low affinity immunoglobulin gamma Fc region receptor II-c FCGR2C 0.0021
3820 Low affinity immunoglobulin gamma Fc region receptor II-b FCGR2B 0.002
132 ATP-binding cassette sub-family A member 1 ABCA1 0.002
768 FK506-binding protein 1A FKBP1A 0.002
153 Dopamine beta-hydroxylase DBH 0.002
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.002
784 High affinity immunoglobulin gamma Fc receptor I FCGR1A 0.0019
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0019
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0019
867 Penicillin-binding protein 3 pbpC 0.0019
6119 Penicillin-binding protein 3 pbp3 0.0019
7154 Penicillin-binding protein 3 pbp3 0.0019
7157 Penicillin-binding protein 3 LMHCC_2184 0.0019
7162 Penicillin-binding protein 3 pbpB 0.0019
7172 Penicillin-binding protein 3 pbp3 0.0019
162 Retinoic acid receptor gamma-1 RARG 0.0019
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0019
1654 Interleukin-1 beta IL1B 0.0019
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0019
518 Peroxidase/catalase T katG 0.0019
1517 Beta-3 adrenergic receptor ADRB3 0.0019
199 Monocarboxylate transporter 8 SLC16A2 0.0018
124 Histamine H2 receptor HRH2 0.0018
2391 Ferrochelatase hemH 0.0018
6502 Ferrochelatase DKFZp686P18130 0.0018
1591 Ferrochelatase, mitochondrial FECH 0.0018
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0017
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0017
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0017
1144 Hepatocyte growth factor receptor MET 0.0017
1291 cAMP response element-binding protein CREB1 0.0017
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0017
229 Retinoic acid receptor beta RARB 0.0017
992 Protein tyrosine kinase 2 beta PTK2B 0.0017
730 Retinoic acid receptor alpha RARA 0.0017
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0016
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0016
6163 Copper-transporting ATPase 2 ATP7B 0.0016
6165 Copper-transporting ATPase 1 ATP7A 0.0016
3616 Fatty acid-binding protein, epidermal FABP5 0.0016
5431 Lipid binding protein Not Available 0.0016
5433 UPF0230 protein TM_1468 TM_1468 0.0016
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0016
4948 Cytochrome c-553 Not Available 0.0016
4923 Cytochrome c3 DvMF_2499 0.0016
4945 Cytochrome c3 Not Available 0.0016
4949 Cytochrome c3 DVU_3171 0.0016
4968 Cytochrome c3 cytc3 0.0016
4997 Cytochrome c3 SO_2727 0.0016
5219 Cytochrome c3 cyd 0.0016
3189 High-molecular-weight cytochrome c hmcA 0.0016
4902 Nine-heme cytochrome c Ddes_2038 0.0016
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0015
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0015
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0015
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0015
6493 Cytochrome c oxidase subunit 6C COX6C 0.0015
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0015
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0015
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0015
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0015
6559 Cytochrome c oxidase subunit 2 ctaC 0.0015
6669 Cytochrome c oxidase subunit 2 ctaC 0.0015
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0015
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0015
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0015
6558 Cytochrome c oxidase subunit 1 ctaD 0.0015
494 Caspase-1 CASP1 0.0015
4785 Ig gamma-1 chain C region IGHG1 0.0015
4120 NADPH--cytochrome P450 reductase POR 0.0015
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0015
208 DNA-directed RNA polymerase beta' chain rpoC 0.0015
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0015
517 Alcohol dehydrogenase 1C ADH1C 0.0015
3611 Cytidine deaminase cdd 0.0014
3707 Cytidine deaminase cdd 0.0014
4211 Cytidine deaminase CDA 0.0014
1010 Cytochrome P450 51A1 CYP51A1 0.0014
378 Alpha-2C adrenergic receptor ADRA2C 0.0014
432 D(4) dopamine receptor DRD4 0.0014
2540 Choloylglycine hydrolase cbh 0.0014
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0014
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0014
2232 Interleukin-5 IL5 0.0014
1593 Mucin-2 MUC2 0.0014
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0014
4386 Hemoglobin-like protein HbN glbN 0.0014
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0013
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0013
1268 Neuropeptide S receptor NPSR1 0.0013
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0013
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0013
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0013
6151 Monocarboxylate transporter 10 SLC16A10 0.0013
283 SEC14-like protein 2 SEC14L2 0.0013
4943 Cytochrome c6 petJ 0.0013
4954 Soluble cytochrome b558 Not Available 0.0013
4934 Cytochrome c-551 nirM 0.0013
5218 Cytochrome c-551 nirM 0.0013
4905 Cytochrome c2 Not Available 0.0013
4939 Cytochrome c2 cycA 0.0013
4964 Cytochrome c2 cycA 0.0013
4979 Cytochrome c2 cycA 0.0013
6673 Cytochrome c2 cycA 0.0013
4984 Neuroglobin NGB 0.0013
4947 Bacterial hemoglobin vhb 0.0013
4994 Hemoglobin-like protein HbO glbO 0.0013
4916 Cyanoglobin glbN 0.0013
4942 Diheme cytochrome c napB napB 0.0013
4925 Cytochrome c-type protein SHP shp 0.0013
4998 Hemoglobin-like protein yjbI yjbI 0.0013
4915 Cytochrome c-550 psbV 0.0013
4959 Cytochrome c-550 psbV 0.0013
5216 Cytochrome c-550 psbV 0.0013
4975 Cytochrome c-556 RPA3973 0.0013
5000 HemO hemO 0.0013
4961 Hemophore HasA hasA 0.0013
4981 Iron-starvation protein PigA pigA 0.0013
4936 Cytochrome c2 iso-2 Not Available 0.0013
4910 Cytoglobin CYGB 0.0013
644 Heme oxygenase 2 HMOX2 0.0013
4982 Heme oxygenase 2 pbsA2 0.0013
3116 Bacterioferritin bfr 0.0013
4906 Bacterioferritin bfr 0.0013
4965 Bacterioferritin bfr 0.0013
4909 CooA protein cooA 0.0013
4904 Cytochrome c family protein GSU1996 0.0013
4907 Cytochrome c-L moxG 0.0013
6865 Cytochrome c-L moxG 0.0013
4935 Cytochrome c-554 cycA1 0.0013
4976 Apocytochrome f petA 0.0013
6407 Apocytochrome f petA 0.0013
4971 Nonaheme cytochrome c hmcA 0.0013
4937 Cytochrome oxidase subunit II rcoxA 0.0013
4764 Cytochrome P450 165C4 CYP165C4 0.0013
4989 Cytochrome c551 peroxidase ccp 0.0013
5222 Cytochrome c551 peroxidase ccpA 0.0013
4931 Cytochrome P450 167A1 CYP167A1 0.0013
4926 Heme-based aerotactic transducer hemAT hemAT 0.0013
4999 Cytochrome P450 165B3 CYP165B3 0.0013
4960 Putative cytochrome P450-family protein SCO7417 0.0013
4972 P450cin cinA 0.0013
4903 Methyl-accepting chemotaxis protein Tar4 0.0013
4993 Hydroxylamine oxidoreductase hao1 0.0013
4922 Cytochrome c, putative SO_4144 0.0013
4952 Catalase/peroxidase katA 0.0013
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0013
3093 Catalase HPII katE 0.0013
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0013
2077 Caspase-3 CASP3 0.0013
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0013
6459 Glycodelin PAEP 0.0013
4034 Glutaredoxin-1 GLRX 0.0013
6432 Transporter snf 0.0013
4030 Thioredoxin domain-containing protein 12 TXNDC12 0.0013
4039 CDNA FLJ23636 fis, clone CAS07176 GPX8 0.0013
910 Epididymal secretory glutathione peroxidase GPX5 0.0013
4036 Glutathione peroxidase 6 GPX6 0.0013
903 Glutathione S-transferase A5 GSTA5 0.0013
911 Glutathione peroxidase 3 GPX3 0.0013
4037 Hypothetical protein GPX1 0.0013
4297 Hypothetical protein SP_1951 0.0013
4521 Hypothetical protein BC_2969 0.0013
4540 Hypothetical protein TM_1070 0.0013
4555 Hypothetical protein MT1739 0.0013
4569 Hypothetical protein mshD 0.0013
4578 Hypothetical protein PA3270 0.0013
4747 Hypothetical protein PA3967 0.0013
5177 Hypothetical protein TM_0096 0.0013
5194 Hypothetical protein PA1204 0.0013
5240 Hypothetical protein Rv2991 0.0013
5370 Hypothetical protein TM_1158 0.0013
5710 Hypothetical protein Tb927.5.1360 0.0013
1928 Leukotriene C4 synthase LTC4S 0.0013
4029 Microsomal glutathione S-transferase 3 MGST3 0.0013
4032 Microsomal glutathione S-transferase 1 MGST1 0.0013
4043 Glutaredoxin-2, mitochondrial GLRX2 0.0013
4040 Glutathione peroxidase 7 GPX7 0.0013
907 Glutathione peroxidase 2 GPX2 0.0013
906 Glutathione peroxidase 1 GPX1 0.0013
4035 Glutathione S-transferase Mu 5 GSTM5 0.0013
900 Glutathione S-transferase A4 GSTA4 0.0013
4042 Glutathione transferase omega-2 GSTO2 0.0013
4033 S-formylglutathione hydrolase ESD 0.0013
4038 Glutathione peroxidase 4 GPX4 0.0013
1975 Phospholipid hydroperoxide glutathione peroxidase, mitochondrial GPX4 0.0013
1056 Gamma-glutamyltranspeptidase 1 GGT1 0.0013
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0012
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0012
3221 Cytochrome c4 cc4 0.0012
6073 Potassium channel subfamily K member 9 KCNK9 0.0012
6072 Potassium channel subfamily K member 3 KCNK3 0.0012
29 Tubulin beta-1 chain TUBB1 0.0012
474 Acetylcholinesterase ACHE 0.0011
164 Histamine H4 receptor HRH4 0.0011
3319 Hydroxyacylglutathione hydrolase HAGH 0.0011
897 Glutathione S-transferase kappa 1 GSTK1 0.0011
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0011
898 Glutathione S-transferase A3 GSTA3 0.0011
909 Maleylacetoacetate isomerase GSTZ1 0.0011
1123 Eosinophil cationic protein RNASE3 0.0011
899 Glutathione S-transferase Mu 3 GSTM3 0.0011
905 Glutathione transferase omega-1 GSTO1 0.0011
4041 Microsomal glutathione S-transferase 2 MGST2 0.0011
6174 50S ribosomal protein L32 rpmF 0.0011
4238 50S ribosomal protein L4 rplD 0.0011
5578 50S ribosomal protein L4 rplD 0.0011
6173 50S ribosomal protein L4 rplD 0.0011
6219 50S ribosomal protein L4 rplD 0.0011
6100 BDNF/NT-3 growth factors receptor NTRK2 0.001
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.001
997 Protein kinase C beta type PRKCB 0.001
563 Thyroid peroxidase TPO 0.001
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.001
2165 Glutathione S-transferase Mu 2 GSTM2 0.001
4920 Peroxidase/catalase katG 0.001
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.001
207 Glutathione synthetase GSS 0.001
5269 Glutathione synthetase gshB 0.001
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.001
2119 Cytochrome b5 CYB5A 0.001
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.001
4990 PpcA ppcA 0.001
16 Adenosine A1 receptor ADORA1 0.001
4289 Cytochrome P450 TT_P0059 0.001
6262 Cytochrome P450 staP 0.001
3570 Cytochrome P450 152A1 cypC 0.001
4992 Cytochrome c peroxidase Not Available 0.001
4988 Sulfite oxidase, mitochondrial SUOX 0.001
2915 Sensor protein fixL fixL 0.001
4944 Sensor protein fixL fixL 0.001
3375 Acidic cytochrome c3 Not Available 0.001
1178 Adenosine A2a receptor ADORA2A 0.001
4385 Cytochrome c' Not Available 0.001
4967 Cytochrome c' cycA 0.001
5038 Cytochrome c' Not Available 0.001
5223 Cytochrome c' cycP 0.001
4813 Heme oxygenase hmuO 0.001
5769 Heme oxygenase Not Available 0.001
1970 Protein kinase C alpha type PRKCA 0.001
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.001
163 D(1B) dopamine receptor DRD5 0.0009
2230 Catalase CAT 0.0009
3249 Catalase katA 0.0009
3625 Catalase katA 0.0009
4539 Catalase katA 0.0009
4941 Catalase katB 0.0009
2408 Tyrosine-protein kinase SYK SYK 0.0009
901 Glutathione S-transferase Mu 4 GSTM4 0.0009
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0009
233 Potassium channel subfamily K member 2 KCNK2 0.0009
1341 Histamine H3 receptor HRH3 0.0009
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0009
84 Nuclear receptor 0B1 NR0B1 0.0009
1256 5-hydroxytryptamine 6 receptor HTR6 0.0009
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0009
3670 Soluble cytochrome b562 precursor cybC 0.0009
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0009
3411 Cytochrome P450 121 cyp121 0.0009
1184 Interferon beta IFNB1 0.0008
2617 Nitric oxide synthase oxygenase nos 0.0008
2701 Nitric oxide synthase oxygenase nos 0.0008
3291 Cytochrome c-552 cycA 0.0008
4927 Cytochrome c-552 nrfA 0.0008
4938 Cytochrome c-552 cycA 0.0008
4953 Cytochrome c-552 nrfA 0.0008
5217 Cytochrome c-552 cycM 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
3102 Flavohemoprotein hmp 0.0008
4969 Flavohemoprotein hmp 0.0008
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0008
714 Glutathione reductase, mitochondrial GSR 0.0008
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0008
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0008
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0008
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0008
581 Cytochrome P450 2R1 CYP2R1 0.0008
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0008
605 Fumarate reductase flavoprotein subunit frdA 0.0008
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0008
3673 Fumarate reductase flavoprotein subunit fccA 0.0008
4912 Fumarate reductase flavoprotein subunit ifcA 0.0008
6549 Fumarate reductase flavoprotein subunit frdA 0.0008
2972 6-deoxyerythronolide B hydroxylase eryF 0.0008
3830 Calreticulin CALR 0.0008
161 Tubulin beta chain TUBB 0.0008
312 Tubulin beta chain TUB2 0.0008
76 Nitric-oxide synthase, brain NOS1 0.0007
4608 Putative cytochrome P450 SCO1207 0.0007
4963 Putative cytochrome P450 SCO2884 0.0007
6254 Putative cytochrome P450 SCO6998 0.0007
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0007
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0007
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0007
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0007
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0007
6034 Hydroxyindole O-methyltransferase ASMT 0.0007
6035 Nuclear receptor ROR-beta RORB 0.0007
6036 Eosinophil peroxidase EPX 0.0007
976 Platelet glycoprotein IX GP9 0.0007
4666 Fucose-binding lectin PA-IIL lecB 0.0007
358 Cystathionine beta-synthase CBS 0.0007
2372 Bifunctional tail protein 9 0.0007
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0007
814 Ryanodine receptor 1 RYR1 0.0007
693 Hemoglobin subunit beta HBB 0.0006
4878 Glycoprotein hormones alpha chain CGA 0.0006
1052 Cytotoxic T-lymphocyte protein 4 CTLA4 0.0006
1072 Granzyme B GZMB 0.0006
4871 Endo-beta-N-acetylglucosaminidase F3 endOF3 0.0006
4880 Membrane cofactor protein CD46 0.0006
4889 Ig epsilon chain C region IGHE 0.0006
4877 Beta-mannanase man 0.0006
1563 Platelet glycoprotein Ib alpha chain GP1BA 0.0006
4850 Beta-2-glycoprotein 1 APOH 0.0006
4856 CD209 antigen CD209 0.0006
4189 Alpha-galactosidase A GLA 0.0006
4869 Major capsid protein A430L 0.0006
757 Fusion glycoprotein F0 F 0.0006
4875 Fusion glycoprotein F0 F 0.0006
4852 Reticulon-4 receptor RTN4R 0.0006
4845 ADAM 33 ADAM33 0.0006
1354 Beta-glucuronidase GUSB 0.0006
442 Envelope glycoprotein gp41 0.0006
4859 Envelope glycoprotein env 0.0006
4882 Dipeptidyl aminopeptidase-like protein 6 DPP6 0.0006
4721 Beta-1,4-mannanase manA 0.0006
3352 Structural polyprotein Not Available 0.0006
3628 Structural polyprotein Not Available 0.0006
4892 Structural polyprotein Not Available 0.0006
239 Coagulation factor X F10 0.0006
251 Alcohol dehydrogenase 1A ADH1A 0.0006
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0006
6268 Hydroxyacid oxidase 1 HAO1 0.0006
174 Sigma 1-type opioid receptor SIGMAR1 0.0006
765 Indoleamine 2,3-dioxygenase IDO1 0.0006
6048 Troponin C, skeletal muscle TNNC2 0.0006
810 Heme oxygenase 1 HMOX1 0.0006
3391 Heme oxygenase 1 pbsA1 0.0006
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0006
719 Retinoic acid receptor responder protein 1 RARRES1 0.0006
770 Retinoic acid-induced protein 3 GPRC5A 0.0006
820 Glycine receptor subunit alpha-2 GLRA2 0.0006
268 Adenosine A2b receptor ADORA2B 0.0006
4193 Atrial natriuretic peptide clearance receptor NPR3 0.0006
793 T-cell surface antigen CD2 CD2 0.0006
4861 Interleukin-6 receptor alpha chain IL6R 0.0006
119 Carcinoembryonic antigen-related cell adhesion molecule 1 CEACAM1 0.0006
3837 Cytokine receptor common beta chain CSF2RB 0.0006
5221 Cytochrome c3, 13 kDa Not Available 0.0006
3152 Cytochrome c'' cycA 0.0006
5220 Split-Soret cytochrome c Ddes_2150 0.0006
3700 Cytochrome c-552 precursor nrfA 0.0006
444 Alcohol dehydrogenase 1B ADH1B 0.0005
856 Vitamin D3 receptor VDR 0.0005
2430 Chondroitinase B cslB 0.0005
2298 Cytochrome P450-cam camC 0.0005
6743 Non-fluorescent flavoprotein luxF 0.0005
6753 Apolipoprotein M APOM 0.0005
2528 Fatty acid metabolism regulator protein fadR 0.0005
6740 Fatty acid metabolism regulator protein fadR 0.0005
6752 Guanylyl cyclase-activating protein 1 GUCA1A 0.0005
394 Calcineurin subunit B isoform 1 PPP3R1 0.0005
6742 Recoverin RCVRN 0.0005
6747 Chalcone/stilbene synthase family protein MT1417 0.0005
6741 Peroxisomal 3,2-trans-enoyl-CoA isomerase PECI 0.0005
6522 Hepatocyte nuclear factor 4-alpha HNF4A 0.0005
6751 Gag polyprotein gag 0.0005
6746 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform PPP3CA 0.0005
6749 Polyprotein Not Available 0.0005
5924 Microtubule-associated protein 4 MAP4 0.0005
5923 Microtubule-associated protein tau MAPT 0.0005
569 Retinal dehydrogenase 2 ALDH1A2 0.0005
2427 Ferrichrome-iron receptor fhuA 0.0005
1379 Interleukin-12 subunit beta IL12B 0.0005
4890 Hemagglutinin HA 0.0005
6566 Hemagglutinin Not Available 0.0005
1852 Microtubule-associated protein 2 MAP2 0.0005
611 Retinal dehydrogenase 1 ALDH1A1 0.0005
3127 Nitrite reductase nirS 0.0005
3284 Nitrite reductase nirS 0.0005
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0005
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0005
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0005
4857 Zinc-alpha-2-glycoprotein AZGP1 0.0005
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0005
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0005
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0005
6858 Inactive carboxylesterase 4 CES1P1 0.0005
5961 Insulin INS 0.0005
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0005
6120 Cation-independent mannose-6-phosphate receptor IGF2R 0.0005
6527 Lymphocyte antigen 96 LY96 0.0005
18 High affinity immunoglobulin epsilon receptor subunit alpha FCER1A 0.0005
6755 Poliovirus receptor PVR 0.0005
751 Potassium channel subfamily K member 6 KCNK6 0.0004
554 Low-density lipoprotein receptor LDLR 0.0004
852 Heparin cofactor 2 SERPIND1 0.0004
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0004
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0004
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0004
3405 Quinohaemoprotein ethanol dehydrogenase type-1 qheDH 0.0004
1859 Prostatic acid phosphatase ACPP 0.0004
6750 ADP-ribosylation factor 6 ARF6 0.0004
4373 Medium-chain-fatty-acid--CoA ligase Not Available 0.0004
6524 Protein tonB tonB 0.0004
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0004
3140 Hemagglutinin-neuraminidase HN 0.0004
3609 Hemagglutinin-neuraminidase HN 0.0004
172 Potassium channel subfamily K member 1 KCNK1 0.0004
3444 Cyanovirin-N Not Available 0.0004
3258 Mannosyl-oligosaccharide alpha-1,2-mannosidase MSDC 0.0004
2616 Ganglioside GM2 activator GM2A 0.0004
2435 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase lpxC 0.0004
6613 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase lpxC 0.0004
4509 Acetoin(diacetyl) reductase budC 0.0004
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0004
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0004
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0004
958 Insulin-like growth factor 1 receptor IGF1R 0.0004
469 Annexin A1 ANXA1 0.0004
3689 Endoglucanase A celA 0.0004
3009 Beta-glucanase Not Available 0.0004
5411 Slt-IIvB stxB2e 0.0004
5565 Inorganic polyphosphate/ATP-glucomannokinase ppgmk 0.0004
5563 Galectin-2 LGALS2 0.0004
1875 Pulmonary surfactant-associated protein D SFTPD 0.0004
5569 Endo-1,4-beta glucanase EngF engF 0.0004
5046 Ecotin eco 0.0004
3793 Aspartate ammonia-lyase aspA 0.0004
5554 D-galactose-binding periplasmic protein mglB 0.0004
3741 D-galactose-binding periplasmic protein precursor mglB 0.0004
5568 Endoglucanase C307 celC307 0.0004
5553 Endoglucanase E1 Acel_0614 0.0004
5562 Hexokinase Not Available 0.0004
3744 Endoglucanase SS precursor celS 0.0004
5570 Endoglucanase E-4 celD 0.0004
5559 Neopullulanase nplT 0.0004
4670 Cellulase B celB 0.0004
4668 Laminarinase TM_0024 0.0004
4667 BH0236 protein BH0236 0.0004
4671 Endoglucanase C cenC 0.0004
6316 ADP-ribosylation factor 1 ARF1 0.0004
2577 Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase MAN1B1 0.0004
1243 Cathepsin D CTSD 0.0003
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0003
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0003
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0003
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0003
864 Gag-Pol polyprotein gag-pol 0.0003
2237 Gag-Pol polyprotein gag-pol 0.0003
2326 Gag-Pol polyprotein gag-pol 0.0003
2451 Gag-Pol polyprotein gag-pol 0.0003
2901 Gag-Pol polyprotein gag-pol 0.0003
3165 Gag-Pol polyprotein gag-pol 0.0003
3722 Gag-Pol polyprotein gag-pol 0.0003
6306 Gag-Pol polyprotein gag-pol 0.0003
6624 Gag-Pol polyprotein gag-pol 0.0003
309 Antithrombin-III SERPINC1 0.0003
1782 Neutrophil gelatinase-associated lipocalin LCN2 0.0003
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0003
5176 YtnJ moxC 0.0003
5416 Coat protein VP1 Not Available 0.0003
2705 Dimethyl sulfoxide reductase dmsA 0.0003
5247 Endo-1,4-beta-xylanase Not Available 0.0003
5248 Endo-1,4-beta-xylanase xlnA 0.0003
5250 Endo-1,4-beta-xylanase xyl 0.0003
4669 Endo-1,4-beta-xylanase A xynA 0.0003
4715 Endo-1,4-beta-xylanase A xlnA 0.0003
5560 Endo-1,4-beta-xylanase A xynA 0.0003
1503 Galectin-7 LGALS7 0.0003
5498 Maltoporin lamB 0.0003
5561 Maltoporin lamB 0.0003
5056 Maltooligosyltrehalose trehalohydrolase, putative treZ 0.0003
3525 ADP-ribose pyrophosphatase, mitochondrial NUDT9 0.0003
4622 Amylase Not Available 0.0003
2728 Glucan 1,4-alpha-maltotetraohydrolase amyP 0.0003
6307 Ig gamma-2 chain C region IGHG2 0.0003
2826 Glucose--fructose oxidoreductase gfo 0.0003
1881 Hexokinase-1 HK1 0.0003
2581 Chondroitinase AC cslA 0.0003
6847 Lactase-phlorizin hydrolase LCT 0.0003
2324 Botulinum neurotoxin type B botB 0.0003
6228 Nuclear receptor coactivator 1 NCOA1 0.0003
3153 Quinoprotein glucose dehydrogenase-B gdhB 0.0003
3747 Cellulase B precursor celB 0.0003
3547 Enterotoxin type B entB 0.0003
2856 Glucosamine-6-phosphate isomerase GNPDA1 0.0003
2564 Glucan 1,4-alpha-maltohexaosidase Not Available 0.0003
4819 Hydrolase Not Available 0.0003
5249 Hydrolase Not Available 0.0003
5436 Hydrolase Not Available 0.0003
2531 Alpha-amylase amyE 0.0003
2948 Alpha-amylase amy 0.0003
3169 Alpha-amylase Not Available 0.0003
2541 Neopullulanase 1 tvaI 0.0003
4811 Amylosucrase ams 0.0003
3091 Maltodextrin phosphorylase malP 0.0003
2606 Neopullulanase 2 tvaII 0.0003
6264 cAMP-dependent protein kinase inhibitor alpha PKIA 0.0003
3225 Shiga toxin B-chain stxB 0.0003
3365 Beta-amylase spoII 0.0003
4830 Aldose 1-epimerase galM 0.0003
6614 Lactase-like protein LCTL 0.0003
1675 Glucokinase GCK 0.0003
4662 Glucokinase glk 0.0003
3030 Salivary alpha-amylase AMY1A 0.0003
2293 Cyclomaltodextrin glucanotransferase Not Available 0.0003
2508 Cyclomaltodextrin glucanotransferase cgt 0.0003
2523 Cyclomaltodextrin glucanotransferase cgt 0.0003
3207 Cyclomaltodextrin glucanotransferase amyA 0.0003
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0003
4272 POSSIBLE CELLULASE CELA1 celA1 0.0003
2570 Tetanus toxin tetX 0.0002
2448 Exoglucanase/xylanase [Includes: Exoglucanase cex 0.0002
3668 Maltose-binding periplasmic protein precursor malE 0.0002
2802 Endoglucanase G celCCG 0.0002
2440 Endoglucanase F celCCF 0.0002
2245 Xylose isomerase xylA 0.0002
2253 Xylose isomerase xylA 0.0002
2260 Xylose isomerase xylA 0.0002
2431 Xylose isomerase xylA 0.0002
2252 Endoglucanase 5A cel5A 0.0002
10 Glycogen phosphorylase, liver form PYGL 0.0002
2723 Cholera enterotoxin subunit B ctxB 0.0002
4513 Pancreatic alpha-amylase AMY2A 0.0002
1152 Glycogen phosphorylase, muscle form PYGM 0.0002
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