DT-Web

DB00573 - Fenoprofen


Identification
Name Fenoprofen
Accession Number DB00573 (APRD00970)
Type small molecule
Description An anti-inflammatory analgesic and antipyretic highly bound to plasma proteins. It is pharmacologically similar to aspirin, but causes less gastrointestinal bleeding. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 242.2699
Groups approved
Monoisotopic Weight 242.094294314
Pharmacology
Indication For relief of the signs and symptoms of rheumatoid arthritis and osteoarthritis. Also for the relief of mild to moderate pain.
Mechanism of action Fenoprofen's exact mode of action is unknown, but it is thought that prostaglandin synthetase inhibition is involved. Fenoprofen has been shown to inhibit prostaglandin synthetase isolated from bovine seminal vesicles.
Absorption Rapidly absorbed under fasting conditions, and peak plasma levels of 50 µg/mL are achieved within 2 hours after oral administration of 600 mg doses.
Protein binding 99% to albumin.
Biotransformation About 90% of a single oral dose is eliminated within 24 hours as fenoprofen glucuronide and 4'-hydroxyfenoprofen glucuronide, the major urinary metabolites of fenoprofen.
Route of elimination Not Available
Toxicity Symptoms of overdose appear within several hours and generally involve the gastrointestinal and central nervous systems. They include dyspepsia, nausea, vomiting, abdominal pain, dizziness, headache, ataxia, tinnitus, tremor, drowsiness, and confusion. Hyperpyrexia, tachycardia, hypotension, and acute renal failure may occur rarely following overdose. Respiratory depression and metabolic acidosis have also been reported following overdose with certain NSAIDs.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Acenocoumarol The NSAID, fenoprofen, may increase the anticoagulant effect of acenocoumarol.
Alendronate Increased risk of gastric toxicity
Anisindione The NSAID, fenoprofen, may increase the anticoagulant effect of anisindione.
Azilsartan medoxomil Increases toxicity of each. May deteriorate renal function, particularly in volume depleted or elderly patients. Decreases effects of azilsartan by antagonism.
Colesevelam Bile acid sequestrants may decrease the absorption of Nonsteroidal Anti-Inflammatory Agents. Monitor for decreased serum concentrations/therapeutic effects of nonsteroidal anti-inflammatory agents (NSAID) if coadministered with bile acid sequestrants. Separating the administration of doses by 2 or more hours may reduce (but not eliminate) the risk of interaction. The manufacturer of colesevelam recommends that drugs should be administered at least 1 hour before or 4 hours after colesevelam.
Cyclosporine Monitor for nephrotoxicity
Dicumarol The NSAID, fenoprofen, may increase the anticoagulant effect of dicumarol.
Eltrombopag Increases levels of Fenoprofen via metabolism decrease. UDP-glucuronosyltransferase inhibition.
Ginkgo biloba Additive anticoagulant/antiplatelet effects may increase bleed risk. Concomitant therapy should be avoided.
Methotrexate The NSAID, fenoprofen, may decrease the renal excretion of methotrexate. Increased risk of methotrexate toxicity.
Pralatrexate NSAIDs increase the risk of toxicity due to impairment of renal clearance of pralatrexate thus increasing exposure. Monitor for adverse effects or adjust dose of pralatrexate.
Telmisartan Concomitant use of Telmisartan and Fenoprofen may increase the risk of acute renal failure and hyperkalemia. Monitor renal function at the beginning and during treatment.
Timolol The NSAID, Fenoprofen, may antagonize the antihypertensive effect of Timolol.
Trandolapril The NSAID, Fenoprofen, may reduce the antihypertensive effect of Trandolapril. Consider alternate therapy or monitor for changes in Trandolapril efficacy if Fenoprofen is initiated, discontinued or dose changed.
Treprostinil The prostacyclin analogue, Treprostinil, may increase the risk of bleeding when combined with the NSAID, Fenoprofen. Monitor for increased bleeding during concomitant thearpy.
Warfarin The antiplatelet effects of fenoprofen may increase the bleed risk associated with warfarin. Consider alternate therapy or monitor for signs and symptoms of bleeding during concomitant therapy.
Food Interactions
  • Take with food to reduce irritation.
  • Avoid alcohol.

Targets


Prostaglandin G/H synthase 2
Name Prostaglandin G/H synthase 2
Gene Name PTGS2
Pharmacological action yes
Actions inhibitor
References
  • Poggi JC, Barissa GR, Donadi EA, Foss MC, Cunha FQ, Lanchote VL, dos Reis ML: Pharmacodynamics, chiral pharmacokinetics, and pharmacokinetic-pharmacodynamic modeling of fenoprofen in patients with diabetes mellitus. J Clin Pharmacol. 2006 Nov;46(11):1328-36. - Pubmed
DTHybrid score 0.5164
Prostaglandin G/H synthase 1
Name Prostaglandin G/H synthase 1
Gene Name PTGS1
Pharmacological action unknown
Actions inhibitor
References
  • Poggi JC, Barissa GR, Donadi EA, Foss MC, Cunha FQ, Lanchote VL, dos Reis ML: Pharmacodynamics, chiral pharmacokinetics, and pharmacokinetic-pharmacodynamic modeling of fenoprofen in patients with diabetes mellitus. J Clin Pharmacol. 2006 Nov;46(11):1328-36. - Pubmed
DTHybrid score 0.5663

Carriers


Predictions


Id Partner name Gene Name Score
4757 Cytochrome P450 2C9 CYP2C9 0.1311
4512 Cytochrome P450 3A4 CYP3A4 0.0871
1729 Solute carrier family 22 member 6 SLC22A6 0.0828
4924 Cytochrome P450 2C8 CYP2C8 0.0685
4200 Cytochrome P450 1A2 CYP1A2 0.0595
6016 Cytochrome P450 2C19 CYP2C19 0.0588
1588 Multidrug resistance protein 1 ABCB1 0.0467
275 Arachidonate 5-lipoxygenase ALOX5 0.0452
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0426
6142 Solute carrier family 22 member 8 SLC22A8 0.0367
4119 Cytochrome P450 2D6 CYP2D6 0.0325
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0323
1024 Solute carrier family 22 member 11 SLC22A11 0.0301
1757 Myeloperoxidase MPO 0.0299
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0289
2164 Multidrug resistance-associated protein 4 ABCC4 0.0282
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.028
6013 Cytochrome P450 2E1 CYP2E1 0.0273
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0268
4118 Cytochrome P450 3A5 CYP3A5 0.0254
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0227
891 Dihydropteroate synthase folP 0.0226
5359 Dihydropteroate synthase folP 0.0226
7175 Dihydropteroate synthase sulI 0.0226
6030 Cytochrome P450 2B6 CYP2B6 0.0223
3312 Fatty acid-binding protein, brain FABP7 0.0217
373 Transthyretin TTR 0.0203
6143 Solute carrier family 22 member 7 SLC22A7 0.0197
6024 Cytochrome P450 1A1 CYP1A1 0.0191
1159 Interleukin-6 IL6 0.0185
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0182
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0178
3923 Cholinesterase BCHE 0.0176
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0175
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0174
1389 Transforming growth factor beta-1 TGFB1 0.0169
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0157
5718 Cytochrome P450 2A6 CYP2A6 0.0144
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0144
6541 Peptostreptococcal albumin-binding protein pab 0.0142
6106 Cytochrome P450 2C18 CYP2C18 0.0135
672 Prostaglandin F2-alpha receptor PTGFR 0.0135
703 NADPH azoreductase azr 0.0132
6107 Cytochrome P450 3A7 CYP3A7 0.0128
738 Monocarboxylate transporter 1 SLC16A1 0.0128
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0125
862 Multidrug resistance-associated protein 1 ABCC1 0.0123
850 Vasopressin V1b receptor AVPR1B 0.0122
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.012
146 Androgen receptor AR 0.0118
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0117
777 Tumor necrosis factor TNF 0.0117
853 Farnesyl pyrophosphate synthetase FDPS 0.0113
1507 Cytochrome c CYCS 0.0113
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0111
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0111
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.011
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0109
185 Vasopressin V1a receptor AVPR1A 0.0107
6012 Tryptophan 2,3-dioxygenase TDO2 0.0106
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0106
322 Vasopressin V2 receptor AVPR2 0.0105
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0105
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0103
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0102
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0101
6043 Putative G-protein coupled receptor 44 GPR44 0.01
6145 Solute carrier family 22 member 1 SLC22A1 0.0099
6102 Arylamine N-acetyltransferase 2 NAT2 0.0098
1439 Lactotransferrin LTF 0.0098
2211 Fatty acid-binding protein, heart FABP3 0.0098
6085 Fatty acid-binding protein, intestinal FABP2 0.0097
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0096
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0096
566 Serotransferrin TF 0.0094
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0094
6220 Aryl hydrocarbon receptor AHR 0.0094
558 Solute carrier family 12 member 1 SLC12A1 0.0093
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0091
2853 14 kDa fatty acid-binding protein Not Available 0.009
4132 Chloride channel protein ClC-Ka CLCNKA 0.009
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0089
782 ADP/ATP translocase 2 SLC25A5 0.0086
688 ADP/ATP translocase 3 SLC25A6 0.0086
70 Type-1 angiotensin II receptor AGTR1 0.0084
723 Cytosolic phospholipase A2 PLA2G4A 0.0083
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0083
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0082
1648 Elastin ELN 0.0082
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0081
6525 Group IID secretory phospholipase A2 PLA2G2D 0.008
61 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0079
2644 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0079
2710 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0079
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0077
502 5-hydroxytryptamine 2A receptor HTR2A 0.0077
4221 Vascular endothelial growth factor VEGF 0.0075
5816 Cadherin-5 CDH5 0.0075
3947 Xanthine dehydrogenase/oxidase XDH 0.0075
6033 High affinity interleukin-8 receptor A CXCR1 0.0075
2183 Fatty acid-binding protein, adipocyte FABP4 0.0073
543 Penicillin-binding protein 1B mrcB 0.0072
6186 Penicillin-binding protein 1B ponB 0.0072
6822 Penicillin-binding protein 1b pbp1b 0.0072
6844 Penicillin-binding protein 1b pbp1b 0.0072
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0072
1 Peptidoglycan synthetase ftsI ftsI 0.0071
4155 Peptidoglycan synthetase ftsI ftsI 0.0071
459 Retinoic acid receptor RXR-alpha RXRA 0.0071
645 Penicillin-binding protein 1A mrcA 0.0071
5805 Penicillin-binding protein 1A ponA 0.0071
6185 Penicillin-binding protein 1A mrcA 0.0071
6799 Penicillin-binding protein 1A pbpA 0.0071
6141 Sodium/bile acid cotransporter SLC10A1 0.0071
831 D(2) dopamine receptor DRD2 0.0069
320 5-hydroxytryptamine 1A receptor HTR1A 0.0069
1714 Mitogen-activated protein kinase 3 MAPK3 0.0067
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0067
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0066
36 Insulin receptor INSR 0.0066
130 Prostacyclin synthase PTGIS 0.0065
811 Translocator protein TSPO 0.0065
661 ADP/ATP translocase 1 SLC25A4 0.0064
1898 Cytochrome P450 1B1 CYP1B1 0.0064
183 Vascular endothelial growth factor A VEGFA 0.0064
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0063
537 ATP synthase delta chain, mitochondrial ATP5D 0.0063
1119 Peroxiredoxin-5, mitochondrial PRDX5 0.0063
6149 Solute carrier family 22 member 10 SLC22A10 0.0062
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0061
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0061
705 Glutamate receptor 1 GRIA1 0.0061
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0061
3811 Cytochrome P450 19A1 CYP19A1 0.0061
3823 Cytokine receptor common gamma chain IL2RG 0.0061
482 Glycine receptor subunit alpha-1 GLRA1 0.006
756 Sex hormone-binding globulin SHBG 0.006
134 Tryptophan 5-hydroxylase 1 TPH1 0.006
23 D(1A) dopamine receptor DRD1 0.006
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0059
489 Monocarboxylate transporter 2 SLC16A7 0.0059
1656 CYP2B protein CYP2B 0.0058
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0058
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0058
118 Organic cation/carnitine transporter 2 SLC22A5 0.0058
6500 Phospholipase A2 PLA2G1B 0.0057
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0057
759 Free fatty acid receptor 1 FFAR1 0.0056
1818 Long-chain-fatty-acid--CoA ligase 3 ACSL3 0.0056
6137 Multidrug resistance-associated protein 6 ABCC6 0.0056
556 Alpha-1A adrenergic receptor ADRA1A 0.0055
614 Progesterone receptor PGR 0.0055
4604 Liver carboxylesterase 1 CES1 0.0055
676 Tyrosine 3-monooxygenase TH 0.0054
724 Interleukin-2 receptor alpha chain IL2RA 0.0053
717 Interleukin-2 receptor subunit beta IL2RB 0.0053
1650 Heme carrier protein 1 SLC46A1 0.0051
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.005
6103 Arylamine N-acetyltransferase 1 NAT1 0.005
33 Cystine/glutamate transporter SLC7A11 0.005
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.005
6027 Alkaline phosphatase, tissue-nonspecific isozyme ALPL 0.005
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0049
1053 BC269730_2 FADS1 0.0049
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0049
1395 Sodium/calcium exchanger 1 SLC8A1 0.0049
828 Phenylalanine-4-hydroxylase PAH 0.0049
3109 Phenylalanine-4-hydroxylase phhA 0.0049
6184 D-alanyl-D-alanine carboxypeptidase dacC dacC 0.0048
822 Aldose reductase AKR1B1 0.0048
871 Glucocorticoid receptor NR3C1 0.0048
823 Fibroblast growth factor receptor 2 FGFR2 0.0047
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0047
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0047
3382 Glycolipid transfer protein GLTP 0.0046
1558 Transient receptor potential cation channel subfamily V member 1 TRPV1 0.0046
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0046
1050 Bile salt sulfotransferase SULT2A1 0.0046
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0046
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0045
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0045
115 Penicillin-binding protein 2 mrdA 0.0044
6069 Penicillin-binding protein 2 mrdA 0.0044
6118 Penicillin-binding protein 2 penA 0.0044
6187 Penicillin-binding protein 2 pbpA 0.0044
6686 Penicillin-binding protein 2 pbp2 0.0044
6939 Penicillin-binding protein 2 mrdA 0.0044
7163 Penicillin-binding protein 2 pbpA 0.0044
737 Mineralocorticoid receptor NR3C2 0.0044
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0044
3601 Dihydropteroate synthase 1 folP1 0.0044
3807 Dihydropteroate synthase 1 folP1 0.0044
3808 Dihydropteroate synthase 2 folP2 0.0044
5645 DNA topoisomerase 4 subunit B parE 0.0044
6227 DNA topoisomerase 4 subunit B parE 0.0044
887 DNA gyrase subunit B gyrB 0.0044
4150 DNA gyrase subunit B gyrB 0.0044
6225 DNA gyrase subunit B gyrB 0.0044
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0042
2236 Casein kinase II subunit alpha CSNK2A1 0.0042
847 Mu-type opioid receptor OPRM1 0.0041
844 Epidermal growth factor receptor EGFR 0.0041
2981 Phospholipase A2, membrane associated PLA2G2A 0.0041
291 Nitric-oxide synthase, endothelial NOS3 0.0041
632 Alpha-1B adrenergic receptor ADRA1B 0.0041
7 Nitric oxide synthase, inducible NOS2 0.0041
404 DNA gyrase subunit A gyrA 0.004
6224 DNA gyrase subunit A gyrA 0.004
477 DNA topoisomerase 4 subunit A parC 0.004
886 DNA topoisomerase 4 subunit A parC 0.004
6226 DNA topoisomerase 4 subunit A parC 0.004
696 Kappa-type opioid receptor OPRK1 0.004
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.004
6508 Putative uncharacterized protein srtB 0.004
6543 Putative uncharacterized protein tcp14 0.004
6615 Putative uncharacterized protein MT0785 0.004
6623 Putative uncharacterized protein Not Available 0.004
6806 Putative uncharacterized protein AGR_C_2535 0.004
6813 Putative uncharacterized protein SAV4671 0.004
6815 Putative uncharacterized protein AFE_1514 0.004
6819 Putative uncharacterized protein RUMGNA_03254 0.004
6825 Putative uncharacterized protein CV_3270 0.004
4161 Furin FURIN 0.004
6144 Solute carrier family 22 member 2 SLC22A2 0.004
232 Corticosteroid-binding globulin SERPINA6 0.0039
2021 Thrombomodulin THBD 0.0039
6067 Penicillin binding protein 2a mecA 0.0038
904 Glutathione S-transferase P GSTP1 0.0038
1789 Lymphotoxin-alpha LTA 0.0037
1269 Tumor necrosis factor receptor superfamily member 1B TNFRSF1B 0.0037
595 Fibrinogen alpha chain FGA 0.0036
819 Penicillin-binding protein 4 dacB 0.0036
908 Glutathione S-transferase theta-1 GSTT1 0.0034
2178 Metabotropic glutamate receptor 5 GRM5 0.0033
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0033
2207 Rhodopsin RHO 0.0033
4784 Beta-mannosidase manB 0.0032
6695 Beta-mannosidase BT_0458 0.0032
594 Thyroxine-binding globulin SERPINA7 0.0032
6677 Myelin P2 protein PMP2 0.0032
136 Estrogen receptor ESR1 0.0032
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0032
492 Histamine H1 receptor HRH1 0.0032
467 Delta-type opioid receptor OPRD1 0.0031
824 Sodium-dependent serotonin transporter SLC6A4 0.0031
3760 Penicillin-binding protein 5 precursor dacA 0.0031
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.003
758 Thyroid hormone receptor alpha THRA 0.003
3813 Fibrinogen gamma chain FGG 0.0029
3812 Fibrinogen beta chain [Contains: Fibrinopeptide B] FGB 0.0029
3932 Glutathione S-transferase A2 GSTA2 0.0029
6042 Prostaglandin reductase 2 PTGR2 0.0029
2998 Sialic acid-binding Ig-like lectin 7 SIGLEC7 0.0028
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0028
6148 Multidrug resistance-associated protein 7 ABCC10 0.0028
1278 Pro-epidermal growth factor EGF 0.0028
6136 Multidrug resistance-associated protein 5 ABCC5 0.0028
1192 Sulfotransferase 1A1 SULT1A1 0.0027
346 Thyroid hormone receptor beta-1 THRB 0.0027
1792 Tissue-type plasminogen activator PLAT 0.0027
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0027
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0027
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0027
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0027
889 3-oxoacyl-[acyl-carrier-protein] synthase 1 fabB 0.0027
6860 3-oxoacyl-[acyl-carrier-protein] synthase 1 kasA 0.0027
122 P2Y purinoceptor 12 P2RY12 0.0026
273 Apoptosis regulator Bcl-2 BCL2 0.0026
6014 Cytochrome P450 2A13 CYP2A13 0.0026
1275 Estrogen sulfotransferase SULT1E1 0.0026
663 Solute carrier family 12 member 4 SLC12A4 0.0026
53 Solute carrier family 12 member 5 SLC12A5 0.0026
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0026
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0026
6146 High affinity copper uptake protein 1 SLC31A1 0.0026
427 Substance-P receptor TACR1 0.0025
4252 Penicillin-binding protein 5 dacA 0.0025
4787 Envelope glycoprotein gp160 env 0.0025
4820 Envelope glycoprotein gp160 env 0.0025
5727 Envelope glycoprotein gp160 env 0.0025
4192 DNA topoisomerase 2-beta TOP2B 0.0025
310 Solute carrier family 12 member 2 SLC12A2 0.0024
1867 Major prion protein PRNP 0.0024
3814 Complement C1r subcomponent C1R 0.0024
106 Cannabinoid receptor 2 CNR2 0.0024
159 Penicillin-binding protein 2B penA 0.0024
6121 Penicillin-binding protein 2B penA 0.0024
2297 Genome polyprotein Not Available 0.0024
2322 Genome polyprotein Not Available 0.0024
2694 Genome polyprotein Not Available 0.0024
2719 Genome polyprotein Not Available 0.0024
2860 Genome polyprotein Not Available 0.0024
2928 Genome polyprotein Not Available 0.0024
3160 Genome polyprotein Not Available 0.0024
3260 Genome polyprotein Not Available 0.0024
4783 Genome polyprotein Not Available 0.0024
5726 Genome polyprotein Not Available 0.0024
5779 Genome polyprotein Not Available 0.0024
5867 Genome polyprotein Not Available 0.0024
6253 Genome polyprotein Not Available 0.0024
6301 Genome polyprotein Not Available 0.0024
6380 Genome polyprotein Not Available 0.0024
6381 Genome polyprotein Not Available 0.0024
6437 Genome polyprotein Not Available 0.0024
6520 Genome polyprotein Not Available 0.0024
6521 Genome polyprotein Not Available 0.0024
6652 Genome polyprotein Not Available 0.0024
6734 Genome polyprotein Not Available 0.0024
6735 Genome polyprotein Not Available 0.0024
6736 Genome polyprotein Not Available 0.0024
6737 Genome polyprotein Not Available 0.0024
6738 Genome polyprotein Not Available 0.0024
6739 Genome polyprotein Not Available 0.0024
6744 Genome polyprotein Not Available 0.0024
6748 Genome polyprotein Not Available 0.0024
6894 Genome polyprotein Not Available 0.0024
6898 Genome polyprotein Not Available 0.0024
1629 Transcription factor AP-1 JUN 0.0024
6231 Pepsin A PGA3 0.0024
633 Penicillin-binding proteins 1A/1B pbpA 0.0024
332 Beta-lactamase blaZ 0.0023
2478 Beta-lactamase ampC 0.0023
2613 Beta-lactamase ampC 0.0023
2635 Beta-lactamase ampC 0.0023
2700 Beta-lactamase penP 0.0023
5445 Beta-lactamase blaB 0.0023
6019 Beta-lactamase SHV-7 0.0023
6701 Beta-lactamase cphA 0.0023
68 Cannabinoid receptor 1 CNR1 0.0023
1618 High affinity nerve growth factor receptor NTRK1 0.0023
1313 Lactoylglutathione lyase GLO1 0.0022
2782 Complement C1s subcomponent C1S 0.0022
1525 Heparin-binding growth factor 2 FGF2 0.0022
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0022
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0022
3480 Mannan endo-1,4-beta-mannosidase manA 0.0022
634 Squalene monooxygenase SQLE 0.0022
7196 Squalene monooxygenase ERG1 0.0022
707 72 kDa type IV collagenase MMP2 0.0021
3437 Eosinophil lysophospholipase CLC 0.0021
4210 Toll-like receptor 4 TLR4 0.0021
6209 30S ribosomal protein S19 rpsS 0.0021
6712 30S ribosomal protein S19 rpsS 0.0021
6726 30S ribosomal protein S19 rpsS 0.0021
6207 30S ribosomal protein S14 rpsN 0.0021
789 Alpha-1D adrenergic receptor ADRA1D 0.0021
3817 Complement C1q subcomponent subunit C C1QC 0.0021
3815 Complement C1q subcomponent subunit A C1QA 0.0021
3816 Complement C1q subcomponent subunit B C1QB 0.0021
331 Retinol-binding protein I, cellular RBP1 0.0021
1102 Low affinity immunoglobulin gamma Fc region receptor III-B FCGR3B 0.0021
3818 Low affinity immunoglobulin gamma Fc region receptor III-A FCGR3A 0.0021
3819 Low affinity immunoglobulin gamma Fc region receptor II-a FCGR2A 0.0021
3821 Low affinity immunoglobulin gamma Fc region receptor II-c FCGR2C 0.0021
436 5-hydroxytryptamine 2B receptor HTR2B 0.002
1864 RET proto-oncogene RET 0.002
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.002
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.002
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.002
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.002
3820 Low affinity immunoglobulin gamma Fc region receptor II-b FCGR2B 0.002
6501 Fatty acid-binding protein, liver FABP1 0.002
768 FK506-binding protein 1A FKBP1A 0.002
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.002
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.002
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.002
1992 Vitamin D-binding protein GC 0.002
784 High affinity immunoglobulin gamma Fc receptor I FCGR1A 0.0019
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0019
869 Estrogen receptor beta ESR2 0.0019
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0019
260 Cytochrome P450 51 ERG11 0.0019
761 Cytochrome P450 51 ERG11 0.0019
3163 Cytochrome P450 51 cyp51 0.0019
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0019
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0019
1517 Beta-3 adrenergic receptor ADRB3 0.0019
5787 Angiopoietin-1 receptor TEK 0.0019
6131 Carbonic anhydrase 14 CA14 0.0019
776 Bile salt export pump ABCB11 0.0019
3426 Glutamine synthetase glnA 0.0019
3987 Glutamine synthetase GLUL 0.0019
380 Cytochrome P450 17A1 CYP17A1 0.0018
65 Matrix metalloproteinase-9 Not Available 0.0018
199 Monocarboxylate transporter 8 SLC16A2 0.0018
468 Cytochrome P450 4A11 CYP4A11 0.0018
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0018
817 DNA topoisomerase 2-alpha TOP2A 0.0018
528 5-hydroxytryptamine 1E receptor HTR1E 0.0018
5934 Cytochrome P450 26A1 CYP26A1 0.0018
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0018
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0018
1198 Serum paraoxonase/arylesterase 1 PON1 0.0018
6223 Penicillin-binding protein 1C pbpC 0.0018
1291 cAMP response element-binding protein CREB1 0.0017
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0017
229 Retinoic acid receptor beta RARB 0.0017
780 Retinoic acid receptor RXR-gamma RXRG 0.0017
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0017
730 Retinoic acid receptor alpha RARA 0.0017
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0017
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0016
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0016
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0016
4103 Proteasome subunit beta type 2 PSMB2 0.0016
4102 Proteasome subunit beta type 5 PSMB5 0.0016
4101 Proteasome subunit beta type 1 PSMB1 0.0016
3616 Fatty acid-binding protein, epidermal FABP5 0.0016
5431 Lipid binding protein Not Available 0.0016
5433 UPF0230 protein TM_1468 TM_1468 0.0016
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0016
716 5-hydroxytryptamine 7 receptor HTR7 0.0016
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0016
244 Angiotensin-converting enzyme ACE 0.0016
88 Retinoic acid receptor RXR-beta RXRB 0.0016
162 Retinoic acid receptor gamma-1 RARG 0.0015
1374 Natriuretic peptides B NPPB 0.0015
228 Beta platelet-derived growth factor receptor PDGFRB 0.0015
1827 Gap junction alpha-1 protein GJA1 0.0015
1908 Vascular cell adhesion protein 1 VCAM1 0.0015
4785 Ig gamma-1 chain C region IGHG1 0.0015
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0015
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0015
6147 Solute carrier family 22 member 3 SLC22A3 0.0015
511 5-hydroxytryptamine 1F receptor HTR1F 0.0015
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0015
504 Mast/stem cell growth factor receptor KIT 0.0014
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0014
725 5-hydroxytryptamine 1D receptor HTR1D 0.0014
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0014
465 Calmodulin CALM1 0.0014
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0014
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0014
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0014
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0014
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0014
885 5-hydroxytryptamine 1B receptor HTR1B 0.0014
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0014
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0014
6151 Monocarboxylate transporter 10 SLC16A10 0.0013
283 SEC14-like protein 2 SEC14L2 0.0013
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0013
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0013
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0013
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0013
6459 Glycodelin PAEP 0.0013
6432 Transporter snf 0.0013
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0013
1405 Thiopurine S-methyltransferase TPMT 0.0013
193 Beta-1 adrenergic receptor ADRB1 0.0012
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0012
3917 Methylenetetrahydrofolate reductase MTHFR 0.0012
6163 Copper-transporting ATPase 2 ATP7B 0.0012
6165 Copper-transporting ATPase 1 ATP7A 0.0012
4226 Uridine phosphorylase 2 UPP2 0.0012
4217 Telomerase reverse transcriptase TERT 0.0012
590 5-hydroxytryptamine 2C receptor HTR2C 0.0012
4943 Cytochrome c6 petJ 0.0011
4954 Soluble cytochrome b558 Not Available 0.0011
4905 Cytochrome c2 Not Available 0.0011
4939 Cytochrome c2 cycA 0.0011
4964 Cytochrome c2 cycA 0.0011
4979 Cytochrome c2 cycA 0.0011
6673 Cytochrome c2 cycA 0.0011
4984 Neuroglobin NGB 0.0011
4994 Hemoglobin-like protein HbO glbO 0.0011
4934 Cytochrome c-551 nirM 0.0011
5218 Cytochrome c-551 nirM 0.0011
4942 Diheme cytochrome c napB napB 0.0011
4947 Bacterial hemoglobin vhb 0.0011
4925 Cytochrome c-type protein SHP shp 0.0011
4916 Cyanoglobin glbN 0.0011
4998 Hemoglobin-like protein yjbI yjbI 0.0011
4975 Cytochrome c-556 RPA3973 0.0011
4915 Cytochrome c-550 psbV 0.0011
4959 Cytochrome c-550 psbV 0.0011
5216 Cytochrome c-550 psbV 0.0011
4961 Hemophore HasA hasA 0.0011
5000 HemO hemO 0.0011
4936 Cytochrome c2 iso-2 Not Available 0.0011
4981 Iron-starvation protein PigA pigA 0.0011
4910 Cytoglobin CYGB 0.0011
644 Heme oxygenase 2 HMOX2 0.0011
4982 Heme oxygenase 2 pbsA2 0.0011
3116 Bacterioferritin bfr 0.0011
4906 Bacterioferritin bfr 0.0011
4965 Bacterioferritin bfr 0.0011
4909 CooA protein cooA 0.0011
4904 Cytochrome c family protein GSU1996 0.0011
4976 Apocytochrome f petA 0.0011
6407 Apocytochrome f petA 0.0011
4935 Cytochrome c-554 cycA1 0.0011
4907 Cytochrome c-L moxG 0.0011
6865 Cytochrome c-L moxG 0.0011
4971 Nonaheme cytochrome c hmcA 0.0011
4937 Cytochrome oxidase subunit II rcoxA 0.0011
4764 Cytochrome P450 165C4 CYP165C4 0.0011
4989 Cytochrome c551 peroxidase ccp 0.0011
5222 Cytochrome c551 peroxidase ccpA 0.0011
4931 Cytochrome P450 167A1 CYP167A1 0.0011
4926 Heme-based aerotactic transducer hemAT hemAT 0.0011
4999 Cytochrome P450 165B3 CYP165B3 0.0011
4972 P450cin cinA 0.0011
4960 Putative cytochrome P450-family protein SCO7417 0.0011
4993 Hydroxylamine oxidoreductase hao1 0.0011
4903 Methyl-accepting chemotaxis protein Tar4 0.0011
4952 Catalase/peroxidase katA 0.0011
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0011
4922 Cytochrome c, putative SO_4144 0.0011
3093 Catalase HPII katE 0.0011
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0011
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0011
24 Thymidylate synthase TMP1 0.0011
359 Thymidylate synthase TYMS 0.0011
2626 Thymidylate synthase thyA 0.0011
2729 Thymidylate synthase thyA 0.0011
5352 Thymidylate synthase THYA 0.0011
4225 Uridine phosphorylase 1 UPP1 0.0011
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0011
318 Alpha-2A adrenergic receptor ADRA2A 0.001
1039 Histone deacetylase 9 HDAC9 0.001
2461 D-alanyl-D-alanine carboxypeptidase Not Available 0.001
5756 D-alanyl-D-alanine carboxypeptidase dac 0.001
413 Amidophosphoribosyltransferase PPAT 0.001
2515 Amidophosphoribosyltransferase purF 0.001
3714 Amidophosphoribosyltransferase purF 0.001
896 Glutathione S-transferase Mu 1 GSTM1 0.001
357 Carbonic anhydrase 2 CA2 0.001
2320 Thymidine kinase, cytosolic TK1 0.0009
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0009
1353 DNA topoisomerase 1 TOP1 0.0009
3552 DNA topoisomerase 1 topA 0.0009
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0009
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0009
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0009
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0009
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0009
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0009
233 Potassium channel subfamily K member 2 KCNK2 0.0009
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0009
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0009
4920 Peroxidase/catalase katG 0.0009
921 Glutamate receptor 2 GRIA2 0.0009
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0009
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0009
1268 Neuropeptide S receptor NPSR1 0.0009
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0009
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0009
4923 Cytochrome c3 DvMF_2499 0.0009
4945 Cytochrome c3 Not Available 0.0009
4949 Cytochrome c3 DVU_3171 0.0009
4968 Cytochrome c3 cytc3 0.0009
4997 Cytochrome c3 SO_2727 0.0009
5219 Cytochrome c3 cyd 0.0009
4948 Cytochrome c-553 Not Available 0.0009
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0009
2119 Cytochrome b5 CYB5A 0.0009
3189 High-molecular-weight cytochrome c hmcA 0.0009
4037 Hypothetical protein GPX1 0.0009
4297 Hypothetical protein SP_1951 0.0009
4521 Hypothetical protein BC_2969 0.0009
4540 Hypothetical protein TM_1070 0.0009
4555 Hypothetical protein MT1739 0.0009
4569 Hypothetical protein mshD 0.0009
4578 Hypothetical protein PA3270 0.0009
4747 Hypothetical protein PA3967 0.0009
5177 Hypothetical protein TM_0096 0.0009
5194 Hypothetical protein PA1204 0.0009
5240 Hypothetical protein Rv2991 0.0009
5370 Hypothetical protein TM_1158 0.0009
5710 Hypothetical protein Tb927.5.1360 0.0009
4902 Nine-heme cytochrome c Ddes_2038 0.0009
4990 PpcA ppcA 0.0008
378 Alpha-2C adrenergic receptor ADRA2C 0.0008
4289 Cytochrome P450 TT_P0059 0.0008
6262 Cytochrome P450 staP 0.0008
4992 Cytochrome c peroxidase Not Available 0.0008
3570 Cytochrome P450 152A1 cypC 0.0008
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0008
4988 Sulfite oxidase, mitochondrial SUOX 0.0008
1184 Interferon beta IFNB1 0.0008
2915 Sensor protein fixL fixL 0.0008
4944 Sensor protein fixL fixL 0.0008
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0008
3375 Acidic cytochrome c3 Not Available 0.0008
4385 Cytochrome c' Not Available 0.0008
4967 Cytochrome c' cycA 0.0008
5038 Cytochrome c' Not Available 0.0008
5223 Cytochrome c' cycP 0.0008
4813 Heme oxygenase hmuO 0.0008
5769 Heme oxygenase Not Available 0.0008
3639 Thymidine phosphorylase deoA 0.0008
3936 Thymidine phosphorylase TYMP 0.0008
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0008
629 Alpha-2B adrenergic receptor ADRA2B 0.0008
6218 Pannexin-1 PANX1 0.0008
2230 Catalase CAT 0.0008
3249 Catalase katA 0.0008
3625 Catalase katA 0.0008
4539 Catalase katA 0.0008
4941 Catalase katB 0.0008
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0008
3937 Fatty-acid amide hydrolase FAAH 0.0008
6073 Potassium channel subfamily K member 9 KCNK9 0.0008
6072 Potassium channel subfamily K member 3 KCNK3 0.0008
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0008
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0008
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0008
731 HIV-1 protease HIV-1 protease 0.0008
3670 Soluble cytochrome b562 precursor cybC 0.0007
3411 Cytochrome P450 121 cyp121 0.0007
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0007
2617 Nitric oxide synthase oxygenase nos 0.0007
2701 Nitric oxide synthase oxygenase nos 0.0007
3291 Cytochrome c-552 cycA 0.0007
4927 Cytochrome c-552 nrfA 0.0007
4938 Cytochrome c-552 cycA 0.0007
4953 Cytochrome c-552 nrfA 0.0007
5217 Cytochrome c-552 cycM 0.0007
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0007
766 Beta-2 adrenergic receptor ADRB2 0.0007
4386 Hemoglobin-like protein HbN glbN 0.0007
3102 Flavohemoprotein hmp 0.0007
4969 Flavohemoprotein hmp 0.0007
5818 Folate receptor alpha FOLR1 0.0007
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0007
518 Peroxidase/catalase T katG 0.0007
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0007
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0007
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0007
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0007
76 Nitric-oxide synthase, brain NOS1 0.0007
3127 Nitrite reductase nirS 0.0007
3284 Nitrite reductase nirS 0.0007
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0007
4666 Fucose-binding lectin PA-IIL lecB 0.0007
2372 Bifunctional tail protein 9 0.0007
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0007
3221 Cytochrome c4 cc4 0.0007
605 Fumarate reductase flavoprotein subunit frdA 0.0007
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0007
3673 Fumarate reductase flavoprotein subunit fccA 0.0007
4912 Fumarate reductase flavoprotein subunit ifcA 0.0007
6549 Fumarate reductase flavoprotein subunit frdA 0.0007
2972 6-deoxyerythronolide B hydroxylase eryF 0.0007
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0006
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0006
4878 Glycoprotein hormones alpha chain CGA 0.0006
1052 Cytotoxic T-lymphocyte protein 4 CTLA4 0.0006
1072 Granzyme B GZMB 0.0006
4871 Endo-beta-N-acetylglucosaminidase F3 endOF3 0.0006
4880 Membrane cofactor protein CD46 0.0006
4889 Ig epsilon chain C region IGHE 0.0006
4877 Beta-mannanase man 0.0006
1563 Platelet glycoprotein Ib alpha chain GP1BA 0.0006
4850 Beta-2-glycoprotein 1 APOH 0.0006
4856 CD209 antigen CD209 0.0006
4189 Alpha-galactosidase A GLA 0.0006
4869 Major capsid protein A430L 0.0006
757 Fusion glycoprotein F0 F 0.0006
4875 Fusion glycoprotein F0 F 0.0006
4852 Reticulon-4 receptor RTN4R 0.0006
4845 ADAM 33 ADAM33 0.0006
1354 Beta-glucuronidase GUSB 0.0006
442 Envelope glycoprotein gp41 0.0006
4859 Envelope glycoprotein env 0.0006
4882 Dipeptidyl aminopeptidase-like protein 6 DPP6 0.0006
4721 Beta-1,4-mannanase manA 0.0006
3352 Structural polyprotein Not Available 0.0006
3628 Structural polyprotein Not Available 0.0006
4892 Structural polyprotein Not Available 0.0006
4608 Putative cytochrome P450 SCO1207 0.0006
4963 Putative cytochrome P450 SCO2884 0.0006
6254 Putative cytochrome P450 SCO6998 0.0006
293 Gamma-glutamyl hydrolase GGH 0.0006
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0006
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0006
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0006
358 Cystathionine beta-synthase CBS 0.0006
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0006
693 Hemoglobin subunit beta HBB 0.0006
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0006
4193 Atrial natriuretic peptide clearance receptor NPR3 0.0006
793 T-cell surface antigen CD2 CD2 0.0006
4861 Interleukin-6 receptor alpha chain IL6R 0.0006
119 Carcinoembryonic antigen-related cell adhesion molecule 1 CEACAM1 0.0006
3837 Cytokine receptor common beta chain CSF2RB 0.0006
2430 Chondroitinase B cslB 0.0005
6268 Hydroxyacid oxidase 1 HAO1 0.0005
810 Heme oxygenase 1 HMOX1 0.0005
3391 Heme oxygenase 1 pbsA1 0.0005
6743 Non-fluorescent flavoprotein luxF 0.0005
6753 Apolipoprotein M APOM 0.0005
2528 Fatty acid metabolism regulator protein fadR 0.0005
6740 Fatty acid metabolism regulator protein fadR 0.0005
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0005
6752 Guanylyl cyclase-activating protein 1 GUCA1A 0.0005
394 Calcineurin subunit B isoform 1 PPP3R1 0.0005
6742 Recoverin RCVRN 0.0005
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0005
6747 Chalcone/stilbene synthase family protein MT1417 0.0005
6741 Peroxisomal 3,2-trans-enoyl-CoA isomerase PECI 0.0005
6522 Hepatocyte nuclear factor 4-alpha HNF4A 0.0005
6751 Gag polyprotein gag 0.0005
6746 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform PPP3CA 0.0005
6749 Polyprotein Not Available 0.0005
6031 Cytochrome P450 3A43 CYP3A43 0.0005
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0005
2427 Ferrichrome-iron receptor fhuA 0.0005
1379 Interleukin-12 subunit beta IL12B 0.0005
4890 Hemagglutinin HA 0.0005
6566 Hemagglutinin Not Available 0.0005
4857 Zinc-alpha-2-glycoprotein AZGP1 0.0005
6858 Inactive carboxylesterase 4 CES1P1 0.0005
2298 Cytochrome P450-cam camC 0.0005
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0005
5961 Insulin INS 0.0005
6120 Cation-independent mannose-6-phosphate receptor IGF2R 0.0005
6527 Lymphocyte antigen 96 LY96 0.0005
18 High affinity immunoglobulin epsilon receptor subunit alpha FCER1A 0.0005
6755 Poliovirus receptor PVR 0.0005
554 Low-density lipoprotein receptor LDLR 0.0004
852 Heparin cofactor 2 SERPIND1 0.0004
833 Organic cation/carnitine transporter 1 SLC22A4 0.0004
1256 5-hydroxytryptamine 6 receptor HTR6 0.0004
6020 Aldehyde oxidase AOX1 0.0004
3941 Amine oxidase [flavin-containing] A MAOA 0.0004
1859 Prostatic acid phosphatase ACPP 0.0004
6750 ADP-ribosylation factor 6 ARF6 0.0004
4373 Medium-chain-fatty-acid--CoA ligase Not Available 0.0004
6524 Protein tonB tonB 0.0004
3140 Hemagglutinin-neuraminidase HN 0.0004
3609 Hemagglutinin-neuraminidase HN 0.0004
3444 Cyanovirin-N Not Available 0.0004
3258 Mannosyl-oligosaccharide alpha-1,2-mannosidase MSDC 0.0004
365 Dihydrofolate reductase DHFR 0.0004
2381 Dihydrofolate reductase DFR1 0.0004
2833 Dihydrofolate reductase Not Available 0.0004
2931 Dihydrofolate reductase folA 0.0004
3544 Dihydrofolate reductase folA 0.0004
3682 Dihydrofolate reductase folA 0.0004
6642 Dihydrofolate reductase folA 0.0004
6756 Dihydrofolate reductase dfrA 0.0004
2616 Ganglioside GM2 activator GM2A 0.0004
2435 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase lpxC 0.0004
6613 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase lpxC 0.0004
4509 Acetoin(diacetyl) reductase budC 0.0004
958 Insulin-like growth factor 1 receptor IGF1R 0.0004
163 D(1B) dopamine receptor DRD5 0.0004
341 5-hydroxytryptamine 3 receptor HTR3A 0.0004
3689 Endoglucanase A celA 0.0004
3009 Beta-glucanase Not Available 0.0004
5411 Slt-IIvB stxB2e 0.0004
5565 Inorganic polyphosphate/ATP-glucomannokinase ppgmk 0.0004
5563 Galectin-2 LGALS2 0.0004
1875 Pulmonary surfactant-associated protein D SFTPD 0.0004
5569 Endo-1,4-beta glucanase EngF engF 0.0004
5046 Ecotin eco 0.0004
3793 Aspartate ammonia-lyase aspA 0.0004
5554 D-galactose-binding periplasmic protein mglB 0.0004
3741 D-galactose-binding periplasmic protein precursor mglB 0.0004
5568 Endoglucanase C307 celC307 0.0004
5553 Endoglucanase E1 Acel_0614 0.0004
5562 Hexokinase Not Available 0.0004
3744 Endoglucanase SS precursor celS 0.0004
5570 Endoglucanase E-4 celD 0.0004
5559 Neopullulanase nplT 0.0004
4670 Cellulase B celB 0.0004
4668 Laminarinase TM_0024 0.0004
4667 BH0236 protein BH0236 0.0004
4671 Endoglucanase C cenC 0.0004
64 Neuraminidase NA 0.0004
641 Neuraminidase NA 0.0004
2676 Neuraminidase NA 0.0004
3026 Neuraminidase NA 0.0004
3519 Neuraminidase NA 0.0004
6007 Neuraminidase NA 0.0004
6316 ADP-ribosylation factor 1 ARF1 0.0004
2577 Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase MAN1B1 0.0004
1243 Cathepsin D CTSD 0.0003
432 D(4) dopamine receptor DRD4 0.0003
864 Gag-Pol polyprotein gag-pol 0.0003
2237 Gag-Pol polyprotein gag-pol 0.0003
2326 Gag-Pol polyprotein gag-pol 0.0003
2451 Gag-Pol polyprotein gag-pol 0.0003
2901 Gag-Pol polyprotein gag-pol 0.0003
3165 Gag-Pol polyprotein gag-pol 0.0003
3722 Gag-Pol polyprotein gag-pol 0.0003
6306 Gag-Pol polyprotein gag-pol 0.0003
6624 Gag-Pol polyprotein gag-pol 0.0003
638 D(3) dopamine receptor DRD3 0.0003
309 Antithrombin-III SERPINC1 0.0003
1782 Neutrophil gelatinase-associated lipocalin LCN2 0.0003
5176 YtnJ moxC 0.0003
5416 Coat protein VP1 Not Available 0.0003
2705 Dimethyl sulfoxide reductase dmsA 0.0003
5247 Endo-1,4-beta-xylanase Not Available 0.0003
5248 Endo-1,4-beta-xylanase xlnA 0.0003
5250 Endo-1,4-beta-xylanase xyl 0.0003
4669 Endo-1,4-beta-xylanase A xynA 0.0003
4715 Endo-1,4-beta-xylanase A xlnA 0.0003
5560 Endo-1,4-beta-xylanase A xynA 0.0003
1503 Galectin-7 LGALS7 0.0003
5498 Maltoporin lamB 0.0003
5561 Maltoporin lamB 0.0003
5056 Maltooligosyltrehalose trehalohydrolase, putative treZ 0.0003
3525 ADP-ribose pyrophosphatase, mitochondrial NUDT9 0.0003
4622 Amylase Not Available 0.0003
2728 Glucan 1,4-alpha-maltotetraohydrolase amyP 0.0003
6307 Ig gamma-2 chain C region IGHG2 0.0003
2826 Glucose--fructose oxidoreductase gfo 0.0003
1881 Hexokinase-1 HK1 0.0003
2581 Chondroitinase AC cslA 0.0003
6847 Lactase-phlorizin hydrolase LCT 0.0003
2324 Botulinum neurotoxin type B botB 0.0003
6228 Nuclear receptor coactivator 1 NCOA1 0.0003
3153 Quinoprotein glucose dehydrogenase-B gdhB 0.0003
3747 Cellulase B precursor celB 0.0003
3547 Enterotoxin type B entB 0.0003
2856 Glucosamine-6-phosphate isomerase GNPDA1 0.0003
2564 Glucan 1,4-alpha-maltohexaosidase Not Available 0.0003
4819 Hydrolase Not Available 0.0003
5249 Hydrolase Not Available 0.0003
5436 Hydrolase Not Available 0.0003
2531 Alpha-amylase amyE 0.0003
2948 Alpha-amylase amy 0.0003
3169 Alpha-amylase Not Available 0.0003
2541 Neopullulanase 1 tvaI 0.0003
4811 Amylosucrase ams 0.0003
3091 Maltodextrin phosphorylase malP 0.0003
2606 Neopullulanase 2 tvaII 0.0003
4692 A/G-specific adenine glycosylase mutY 0.0003
6264 cAMP-dependent protein kinase inhibitor alpha PKIA 0.0003
3225 Shiga toxin B-chain stxB 0.0003
3365 Beta-amylase spoII 0.0003
4830 Aldose 1-epimerase galM 0.0003
6614 Lactase-like protein LCTL 0.0003
1675 Glucokinase GCK 0.0003
4662 Glucokinase glk 0.0003
3030 Salivary alpha-amylase AMY1A 0.0003
2293 Cyclomaltodextrin glucanotransferase Not Available 0.0003
2508 Cyclomaltodextrin glucanotransferase cgt 0.0003
2523 Cyclomaltodextrin glucanotransferase cgt 0.0003
3207 Cyclomaltodextrin glucanotransferase amyA 0.0003
4272 POSSIBLE CELLULASE CELA1 celA1 0.0003
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0003
2570 Tetanus toxin tetX 0.0002
2448 Exoglucanase/xylanase [Includes: Exoglucanase cex 0.0002
3668 Maltose-binding periplasmic protein precursor malE 0.0002
2802 Endoglucanase G celCCG 0.0002
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0002
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0002
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0002
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0002
2440 Endoglucanase F celCCF 0.0002
2245 Xylose isomerase xylA 0.0002
2253 Xylose isomerase xylA 0.0002
2260 Xylose isomerase xylA 0.0002
2431 Xylose isomerase xylA 0.0002
2252 Endoglucanase 5A cel5A 0.0002
10 Glycogen phosphorylase, liver form PYGL 0.0002
2723 Cholera enterotoxin subunit B ctxB 0.0002
952 Dipeptidyl peptidase 4 DPP4 0.0002
4513 Pancreatic alpha-amylase AMY2A 0.0002
1152 Glycogen phosphorylase, muscle form PYGM 0.0002
↑