DT-Web

DB08910 - Pomalidomide


Identification
Name Pomalidomide
Accession Number DB08910
Type small molecule
Description Pomalidomide, an analogue of thalidomide, is an immunomodulatory antineoplastic agent. FDA approved on February 8, 2013.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 273.2441
Groups approved
Monoisotopic Weight 273.074955855
Pharmacology
Indication Pomalidomide is indicated for patients with multiple myeloma who have received at least two prior therapies including lenalidomide and bortezomib and have demonstrated disease progression on or within 60 days of completion of the last therapy.
Mechanism of action Promalidomide is an immunomodulatory agent with antineoplastic activity. It is shown to inhibit the proliferation and induce apoptosis of various tumour cells. Furthermore, promalidomide enhances T cell and natural killer (NK) cell-mediated immunity and inhibited the production of pro-inflammatory cytokines, like TNF-alpha or IL-6, by monocytes. The primary target of promalidomide is thought to be the protein cereblon. It binds to this target and inhibits ubiquitin ligase activity. It is also a transcriptional inhibitor of COX2.
Absorption Pomalidomide is generally well absorbed. The major circulating component is the parent compound. Tmax, single oral dose = 2 -3 hours. When 4 mg of promalidomide is given to patients with multiple myeloma, the steady-state pharmacokinetic parameters are as follows: AUC(T) = 400 ng.hr/mL; Cmax = 75 ng/mL. Promalidomide accumulates following multiple doses.
Protein binding 12-44% protein bound. It is not concentration dependent.
Biotransformation Promalidomide is hepatically metabolized by CYP1A2 and CYP3A4. The metabolites are 26-fold less active than the parent compound. Minor contributions from CYP2C19 and CYP2D6 have been observed in vitro.
Route of elimination When a single oral dose (2mg) is given to healthy subjects, 73% of the dose was eliminated in urine. 15% of the dose was eliminated in feces. 2% and 8% of the dose eliminated unchanged as pomalidomide in urine and feces, respectively.
Toxicity Most common adverse reactions (>=30%) included fatigue and asthenia, neutropenia, anemia, constipation, nausea, diarrhea, dyspnea, upper-respiratory tract infections, back pain and pyrexia.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Ketoconazole Strong CYP3A4 inhibitors may increase levels of pomalidomide. Concomitant therapy should be avoided.
Rifampin Strong CYP3A4 inducers may decrease levels of pomalidomide. Concomitant therapy should be avoided.
Food Interactions Not Available

Targets


Protein cereblon
Name Protein cereblon
Gene Name Not Available
Pharmacological action yes
Actions inhibitor
References
  • McCurdy AR, Lacy MQ: Pomalidomide and its clinical potential for relapsed or refractory multiple myeloma: an update for the hematologist. Ther Adv Hematol. 2013 Jun;4(3):211-6. doi: 10.1177/2040620713480155. - Pubmed
  • Ito T, Ando H, Suzuki T, Ogura T, Hotta K, Imamura Y, Yamaguchi Y, Handa H: Identification of a primary target of thalidomide teratogenicity. Science. 2010 Mar 12;327(5971):1345-50. doi: 10.1126/science.1177319. - Pubmed
  • Lopez-Girona A, Mendy D, Ito T, Miller K, Gandhi AK, Kang J, Karasawa S, Carmel G, Jackson P, Abbasian M, Mahmoudi A, Cathers B, Rychak E, Gaidarova S, Chen R, Schafer PH, Handa H, Daniel TO, Evans JF, Chopra R: Cereblon is a direct protein target for immunomodulatory and antiproliferative activities of lenalidomide and pomalidomide. Leukemia. 2012 Nov;26(11):2326-35. doi: 10.1038/leu.2012.119. Epub 2012 May 3. - Pubmed
DTHybrid score Not Available
Tumor necrosis factor
Name Tumor necrosis factor
Gene Name TNF
Pharmacological action yes
Actions inhibitor
References
  • Gertz MA: Pomalidomide and myeloma meningitis. Leuk Lymphoma. 2013 Apr;54(4):681-2. doi: 10.3109/10428194.2012.723708. Epub 2013 Jan 2. - Pubmed
DTHybrid score 0.67
Prostaglandin G/H synthase 2
Name Prostaglandin G/H synthase 2
Gene Name PTGS2
Pharmacological action yes
Actions inhibitor
References
  • Ferguson GD, Jensen-Pergakes K, Wilkey C, Jhaveri U, Richard N, Verhelle D, De Parseval LM, Corral LG, Xie W, Morris CL, Brady H, Chan K: Immunomodulatory drug CC-4047 is a cell-type and stimulus-selective transcriptional inhibitor of cyclooxygenase 2. J Clin Immunol. 2007 Mar;27(2):210-20. Epub 2007 Feb 17. - Pubmed
DTHybrid score 0.4092

Enzymes


Cytochrome P450 1A2
Name Cytochrome P450 1A2
Gene Name CYP1A2
Actions substrate
References
  • FDA label -
DTHybrid score 0.3184
Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate
References
  • FDA label -
DTHybrid score 0.4181

Transporters


Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions substrate
References
  • FDA label -
DTHybrid score 0.3087

Predictions


Id Partner name Gene Name Score
20 Prostaglandin G/H synthase 1 PTGS1 0.2051
4757 Cytochrome P450 2C9 CYP2C9 0.1736
4119 Cytochrome P450 2D6 CYP2D6 0.154
6016 Cytochrome P450 2C19 CYP2C19 0.1399
4118 Cytochrome P450 3A5 CYP3A5 0.1264
4924 Cytochrome P450 2C8 CYP2C8 0.1145
6024 Cytochrome P450 1A1 CYP1A1 0.1009
6013 Cytochrome P450 2E1 CYP2E1 0.093
6030 Cytochrome P450 2B6 CYP2B6 0.0755
6107 Cytochrome P450 3A7 CYP3A7 0.0746
587 Serum albumin ALB 0.0718
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0575
1729 Solute carrier family 22 member 6 SLC22A6 0.0557
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0492
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0454
5718 Cytochrome P450 2A6 CYP2A6 0.0432
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0386
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0368
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0341
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0331
862 Multidrug resistance-associated protein 1 ABCC1 0.0328
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0321
193 Beta-1 adrenergic receptor ADRB1 0.0316
871 Glucocorticoid receptor NR3C1 0.0316
492 Histamine H1 receptor HRH1 0.0312
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0304
3811 Cytochrome P450 19A1 CYP19A1 0.0304
1820 Beta-nerve growth factor NGF 0.0293
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0293
766 Beta-2 adrenergic receptor ADRB2 0.0289
556 Alpha-1A adrenergic receptor ADRA1A 0.0289
3923 Cholinesterase BCHE 0.0281
6142 Solute carrier family 22 member 8 SLC22A8 0.0273
3090 Chitosanase csn 0.0265
4149 Nuclear factor NF-kappa-B p100 subunit NFKB2 0.0265
831 D(2) dopamine receptor DRD2 0.0263
824 Sodium-dependent serotonin transporter SLC6A4 0.0262
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.026
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0259
36 Insulin receptor INSR 0.0258
502 5-hydroxytryptamine 2A receptor HTR2A 0.0255
6145 Solute carrier family 22 member 1 SLC22A1 0.0252
318 Alpha-2A adrenergic receptor ADRA2A 0.0241
1757 Myeloperoxidase MPO 0.0235
2782 Complement C1s subcomponent C1S 0.0235
1898 Cytochrome P450 1B1 CYP1B1 0.0234
6106 Cytochrome P450 2C18 CYP2C18 0.0233
1253 Interferon gamma IFNG 0.023
2164 Multidrug resistance-associated protein 4 ABCC4 0.0228
275 Arachidonate 5-lipoxygenase ALOX5 0.0228
136 Estrogen receptor ESR1 0.0223
1517 Beta-3 adrenergic receptor ADRB3 0.022
2232 Interleukin-5 IL5 0.0219
1593 Mucin-2 MUC2 0.0218
3815 Complement C1q subcomponent subunit A C1QA 0.0217
3816 Complement C1q subcomponent subunit B C1QB 0.0217
3817 Complement C1q subcomponent subunit C C1QC 0.0217
1102 Low affinity immunoglobulin gamma Fc region receptor III-B FCGR3B 0.0215
3818 Low affinity immunoglobulin gamma Fc region receptor III-A FCGR3A 0.0215
3814 Complement C1r subcomponent C1R 0.0215
3819 Low affinity immunoglobulin gamma Fc region receptor II-a FCGR2A 0.0215
3821 Low affinity immunoglobulin gamma Fc region receptor II-c FCGR2C 0.0215
3820 Low affinity immunoglobulin gamma Fc region receptor II-b FCGR2B 0.0213
6144 Solute carrier family 22 member 2 SLC22A2 0.0211
817 DNA topoisomerase 2-alpha TOP2A 0.0208
784 High affinity immunoglobulin gamma Fc receptor I FCGR1A 0.0205
2112 Toll-like receptor 9 TLR9 0.0204
6143 Solute carrier family 22 member 7 SLC22A7 0.0202
23 D(1A) dopamine receptor DRD1 0.0193
1789 Lymphotoxin-alpha LTA 0.0193
1269 Tumor necrosis factor receptor superfamily member 1B TNFRSF1B 0.0193
320 5-hydroxytryptamine 1A receptor HTR1A 0.0189
1159 Interleukin-6 IL6 0.0185
477 DNA topoisomerase 4 subunit A parC 0.0181
886 DNA topoisomerase 4 subunit A parC 0.0181
6226 DNA topoisomerase 4 subunit A parC 0.0181
65 Matrix metalloproteinase-9 Not Available 0.0181
103 Muscarinic acetylcholine receptor M1 CHRM1 0.018
404 DNA gyrase subunit A gyrA 0.0178
6224 DNA gyrase subunit A gyrA 0.0178
776 Bile salt export pump ABCB11 0.0178
1024 Solute carrier family 22 member 11 SLC22A11 0.0177
632 Alpha-1B adrenergic receptor ADRA1B 0.0177
823 Fibroblast growth factor receptor 2 FGFR2 0.0176
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0176
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0176
1123 Eosinophil cationic protein RNASE3 0.0175
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.017
885 5-hydroxytryptamine 1B receptor HTR1B 0.017
118 Organic cation/carnitine transporter 2 SLC22A5 0.0168
3932 Glutathione S-transferase A2 GSTA2 0.0166
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0165
6220 Aryl hydrocarbon receptor AHR 0.0164
590 5-hydroxytryptamine 2C receptor HTR2C 0.0162
731 HIV-1 protease HIV-1 protease 0.0158
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0157
3941 Amine oxidase [flavin-containing] A MAOA 0.0156
725 5-hydroxytryptamine 1D receptor HTR1D 0.0155
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0154
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0151
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0148
373 Transthyretin TTR 0.0148
789 Alpha-1D adrenergic receptor ADRA1D 0.0148
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0146
614 Progesterone receptor PGR 0.0146
847 Mu-type opioid receptor OPRM1 0.0145
3947 Xanthine dehydrogenase/oxidase XDH 0.0144
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0142
629 Alpha-2B adrenergic receptor ADRA2B 0.0136
672 Prostaglandin F2-alpha receptor PTGFR 0.0135
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0134
260 Cytochrome P450 51 ERG11 0.0133
761 Cytochrome P450 51 ERG11 0.0133
3163 Cytochrome P450 51 cyp51 0.0133
232 Corticosteroid-binding globulin SERPINA6 0.013
450 Muscarinic acetylcholine receptor M4 CHRM4 0.013
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.013
146 Androgen receptor AR 0.013
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0129
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0126
638 D(3) dopamine receptor DRD3 0.0124
467 Delta-type opioid receptor OPRD1 0.0124
713 Sodium-dependent dopamine transporter SLC6A3 0.0121
185 Vasopressin V1a receptor AVPR1A 0.0121
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.012
322 Vasopressin V2 receptor AVPR2 0.0118
341 5-hydroxytryptamine 3 receptor HTR3A 0.0118
818 50S ribosomal protein L10 rplJ 0.0115
3939 Amine oxidase [flavin-containing] B MAOB 0.0114
853 Farnesyl pyrophosphate synthetase FDPS 0.0113
3312 Fatty acid-binding protein, brain FABP7 0.0113
378 Alpha-2C adrenergic receptor ADRA2C 0.0113
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0112
465 Calmodulin CALM1 0.0111
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.011
696 Kappa-type opioid receptor OPRK1 0.0107
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0107
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0107
6137 Multidrug resistance-associated protein 6 ABCC6 0.0106
1656 CYP2B protein CYP2B 0.0103
6148 Multidrug resistance-associated protein 7 ABCC10 0.0101
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0101
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.01
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.01
833 Organic cation/carnitine transporter 1 SLC22A4 0.0099
6147 Solute carrier family 22 member 3 SLC22A3 0.0099
4221 Vascular endothelial growth factor VEGF 0.0099
5816 Cadherin-5 CDH5 0.0099
6182 Cytochrome P450 2J2 CYP2J2 0.0098
723 Cytosolic phospholipase A2 PLA2G4A 0.0098
737 Mineralocorticoid receptor NR3C2 0.0098
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0097
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0097
958 Insulin-like growth factor 1 receptor IGF1R 0.0097
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0097
468 Cytochrome P450 4A11 CYP4A11 0.0096
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0096
4604 Liver carboxylesterase 1 CES1 0.0095
436 5-hydroxytryptamine 2B receptor HTR2B 0.0095
1439 Lactotransferrin LTF 0.0095
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0092
122 P2Y purinoceptor 12 P2RY12 0.009
6141 Sodium/bile acid cotransporter SLC10A1 0.0089
474 Acetylcholinesterase ACHE 0.0089
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0088
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0087
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0087
6043 Putative G-protein coupled receptor 44 GPR44 0.0087
782 ADP/ATP translocase 2 SLC25A5 0.0086
688 ADP/ATP translocase 3 SLC25A6 0.0086
844 Epidermal growth factor receptor EGFR 0.0086
1192 Sulfotransferase 1A1 SULT1A1 0.0086
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0085
869 Estrogen receptor beta ESR2 0.0085
16 Adenosine A1 receptor ADORA1 0.0083
4148 Serine/threonine-protein kinase mTOR MTOR 0.0083
432 D(4) dopamine receptor DRD4 0.0083
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0082
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0082
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0081
124 Histamine H2 receptor HRH2 0.0081
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.008
61 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0079
2644 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0079
2710 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0079
1178 Adenosine A2a receptor ADORA2A 0.0079
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0077
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0077
952 Dipeptidyl peptidase 4 DPP4 0.0077
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0077
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0076
504 Mast/stem cell growth factor receptor KIT 0.0076
703 NADPH azoreductase azr 0.0076
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0074
738 Monocarboxylate transporter 1 SLC16A1 0.0074
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0073
161 Tubulin beta chain TUBB 0.0073
312 Tubulin beta chain TUB2 0.0073
1648 Elastin ELN 0.0073
3823 Cytokine receptor common gamma chain IL2RG 0.0073
4237 50S ribosomal protein L22 rplV 0.0073
6031 Cytochrome P450 3A43 CYP3A43 0.0072
756 Sex hormone-binding globulin SHBG 0.0072
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0071
716 5-hydroxytryptamine 7 receptor HTR7 0.007
2449 Tubulin alpha-3 chain TUBA1A 0.007
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.007
850 Vasopressin V1b receptor AVPR1B 0.007
26 Vascular endothelial growth factor receptor 3 FLT4 0.0069
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0069
244 Angiotensin-converting enzyme ACE 0.0068
6102 Arylamine N-acetyltransferase 2 NAT2 0.0068
407 Vascular endothelial growth factor receptor 2 KDR 0.0068
661 ADP/ATP translocase 1 SLC25A4 0.0067
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0067
4120 NADPH--cytochrome P450 reductase POR 0.0067
32 Vascular endothelial growth factor receptor 1 FLT1 0.0066
70 Type-1 angiotensin II receptor AGTR1 0.0066
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0066
29 Tubulin beta-1 chain TUBB1 0.0066
2499 Tubulin beta-2C chain TUBB2C 0.0065
273 Apoptosis regulator Bcl-2 BCL2 0.0065
571 Melatonin receptor type 1A MTNR1A 0.0064
362 Melatonin receptor type 1B MTNR1B 0.0064
828 Phenylalanine-4-hydroxylase PAH 0.0064
3109 Phenylalanine-4-hydroxylase phhA 0.0064
724 Interleukin-2 receptor alpha chain IL2RA 0.0063
717 Interleukin-2 receptor subunit beta IL2RB 0.0063
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0063
3432 Multidrug-efflux transporter 1 regulator bmrR 0.0063
4476 Mannitol dehydrogenase mtlD 0.0063
1353 DNA topoisomerase 1 TOP1 0.0063
3552 DNA topoisomerase 1 topA 0.0063
6136 Multidrug resistance-associated protein 5 ABCC5 0.0062
228 Beta platelet-derived growth factor receptor PDGFRB 0.0062
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0062
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0062
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0061
6012 Tryptophan 2,3-dioxygenase TDO2 0.0061
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.006
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.006
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.006
134 Tryptophan 5-hydroxylase 1 TPH1 0.006
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.006
904 Glutathione S-transferase P GSTP1 0.0059
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0059
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0059
4238 50S ribosomal protein L4 rplD 0.0058
5578 50S ribosomal protein L4 rplD 0.0058
6173 50S ribosomal protein L4 rplD 0.0058
6219 50S ribosomal protein L4 rplD 0.0058
6014 Cytochrome P450 2A13 CYP2A13 0.0058
380 Cytochrome P450 17A1 CYP17A1 0.0057
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0057
163 D(1B) dopamine receptor DRD5 0.0056
511 5-hydroxytryptamine 1F receptor HTR1F 0.0056
6020 Aldehyde oxidase AOX1 0.0056
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0055
676 Tyrosine 3-monooxygenase TH 0.0054
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0053
5998 Toll-like receptor 8 TLR8 0.0053
811 Translocator protein TSPO 0.0052
565 Extracellular calcium-sensing receptor CASR 0.0052
712 Tubulin alpha chain TUB1 0.0052
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0052
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0052
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0051
4132 Chloride channel protein ClC-Ka CLCNKA 0.0051
284 DNA-directed RNA polymerase beta chain rpoB 0.0051
5773 DNA-directed RNA polymerase beta chain rpoB 0.0051
1714 Mitogen-activated protein kinase 3 MAPK3 0.0051
4122 Histone deacetylase 2 HDAC2 0.0051
613 Atrial natriuretic peptide receptor A NPR1 0.005
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.005
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.005
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.005
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.005
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.005
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.005
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0049
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0049
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0049
291 Nitric-oxide synthase, endothelial NOS3 0.0049
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0049
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0049
459 Retinoic acid receptor RXR-alpha RXRA 0.0048
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0048
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0048
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0048
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0048
6149 Solute carrier family 22 member 10 SLC22A10 0.0047
33 Cystine/glutamate transporter SLC7A11 0.0047
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0047
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0047
2616 Ganglioside GM2 activator GM2A 0.0047
683 Potassium transporter GK0582 0.0047
814 Ryanodine receptor 1 RYR1 0.0046
173 Toll-like receptor 7 TLR7 0.0046
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0045
68 Cannabinoid receptor 1 CNR1 0.0045
908 Glutathione S-transferase theta-1 GSTT1 0.0045
130 Prostacyclin synthase PTGIS 0.0044
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0044
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0044
117 Sterol O-acyltransferase 1 SOAT1 0.0043
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0043
6138 Multidrug resistance protein 3 ABCB4 0.0043
1010 Cytochrome P450 51A1 CYP51A1 0.0043
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0043
714 Glutathione reductase, mitochondrial GSR 0.0042
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0042
768 FK506-binding protein 1A FKBP1A 0.0042
1852 Microtubule-associated protein 2 MAP2 0.0042
427 Substance-P receptor TACR1 0.0041
1256 5-hydroxytryptamine 6 receptor HTR6 0.0041
1050 Bile salt sulfotransferase SULT2A1 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
1629 Transcription factor AP-1 JUN 0.004
239 Coagulation factor X F10 0.004
4192 DNA topoisomerase 2-beta TOP2B 0.004
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.004
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.004
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0039
489 Monocarboxylate transporter 2 SLC16A7 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
6085 Fatty acid-binding protein, intestinal FABP2 0.0039
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0038
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0038
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0038
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0038
605 Fumarate reductase flavoprotein subunit frdA 0.0038
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0038
3673 Fumarate reductase flavoprotein subunit fccA 0.0038
4912 Fumarate reductase flavoprotein subunit ifcA 0.0038
6549 Fumarate reductase flavoprotein subunit frdA 0.0038
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0038
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0038
2539 Tubulin alpha-1 chain TUBA4A 0.0037
992 Protein tyrosine kinase 2 beta PTK2B 0.0037
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0037
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0037
2236 Casein kinase II subunit alpha CSNK2A1 0.0037
6044 Serum paraoxonase/lactonase 3 PON3 0.0037
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0036
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0036
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0036
856 Vitamin D3 receptor VDR 0.0035
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0035
6432 Transporter snf 0.0035
4103 Proteasome subunit beta type 2 PSMB2 0.0035
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0035
4102 Proteasome subunit beta type 5 PSMB5 0.0035
4101 Proteasome subunit beta type 1 PSMB1 0.0035
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0035
3957 Adenosine deaminase ADA 0.0035
939 50S ribosomal protein L3 rplC 0.0035
6766 O-GlcNAcase BT_4395 BT_4395 0.0034
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0034
94 5-hydroxytryptamine 4 receptor HTR4 0.0034
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0033
295 Carbonic anhydrase 1 CA1 0.0033
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0033
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0033
365 Dihydrofolate reductase DHFR 0.0033
2381 Dihydrofolate reductase DFR1 0.0033
2833 Dihydrofolate reductase Not Available 0.0033
2931 Dihydrofolate reductase folA 0.0033
3544 Dihydrofolate reductase folA 0.0033
3682 Dihydrofolate reductase folA 0.0033
6642 Dihydrofolate reductase folA 0.0033
6756 Dihydrofolate reductase dfrA 0.0033
6500 Phospholipase A2 PLA2G1B 0.0033
528 5-hydroxytryptamine 1E receptor HTR1E 0.0032
759 Free fatty acid receptor 1 FFAR1 0.0032
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0032
1818 Long-chain-fatty-acid--CoA ligase 3 ACSL3 0.0032
6033 High affinity interleukin-8 receptor A CXCR1 0.0032
592 Carbonic anhydrase 4 CA4 0.0032
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0032
2107 Microtubule-associated protein 1A MAP1A 0.0032
24 Thymidylate synthase TMP1 0.0032
359 Thymidylate synthase TYMS 0.0032
2626 Thymidylate synthase thyA 0.0032
2729 Thymidylate synthase thyA 0.0032
5352 Thymidylate synthase THYA 0.0032
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0031
6146 High affinity copper uptake protein 1 SLC31A1 0.0031
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0031
705 Glutamate receptor 1 GRIA1 0.0031
2578 Tubulin beta-3 chain TUBB3 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
543 Penicillin-binding protein 1B mrcB 0.003
6186 Penicillin-binding protein 1B ponB 0.003
6822 Penicillin-binding protein 1b pbp1b 0.003
6844 Penicillin-binding protein 1b pbp1b 0.003
3601 Dihydropteroate synthase 1 folP1 0.003
3807 Dihydropteroate synthase 1 folP1 0.003
3808 Dihydropteroate synthase 2 folP2 0.003
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.003
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.003
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.003
4228 Keratin, type II cytoskeletal 7 KRT7 0.003
780 Retinoic acid receptor RXR-gamma RXRG 0.003
159 Penicillin-binding protein 2B penA 0.0029
6121 Penicillin-binding protein 2B penA 0.0029
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0029
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0029
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0029
1650 Heme carrier protein 1 SLC46A1 0.0029
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0029
512 DNA-directed RNA polymerase alpha chain rpoA 0.0029
5772 DNA-directed RNA polymerase alpha chain rpoA 0.0029
921 Glutamate receptor 2 GRIA2 0.0028
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0028
319 Opioid receptor, sigma 1 OPRS1 0.0028
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0028
165 FL cytokine receptor FLT3 0.0028
1053 BC269730_2 FADS1 0.0028
1395 Sodium/calcium exchanger 1 SLC8A1 0.0028
1275 Estrogen sulfotransferase SULT1E1 0.0028
3856 Fibroblast growth factor receptor 3 FGFR3 0.0028
2981 Phospholipase A2, membrane associated PLA2G2A 0.0027
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0027
822 Aldose reductase AKR1B1 0.0027
6232 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short GNAS 0.0027
6233 Adenylate cyclase type 2 ADCY2 0.0027
6234 Adenylate cyclase type 5 ADCY5 0.0027
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0027
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
88 Retinoic acid receptor RXR-beta RXRB 0.0027
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0027
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0027
6167 Organic solute transporter subunit beta OSTB 0.0027
6166 Organic solute transporter subunit alpha OSTA 0.0027
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0027
3849 Insulin-like growth factor-binding protein 7 IGFBP7 0.0027
2009 Protein NOV homolog NOV 0.0027
3847 Neuroendocrine convertase 2 PCSK2 0.0027
1949 Carboxypeptidase E CPE 0.0027
3850 Synaptotagmin-like protein 4 SYTL4 0.0027
3848 Neuroendocrine convertase 1 PCSK1 0.0027
3846 Retinoblastoma-associated protein RB1 0.0027
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0026
1558 Transient receptor potential cation channel subfamily V member 1 TRPV1 0.0026
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0026
6824 Tyrosine-protein kinase Lyn LYN 0.0026
6599 HTH-type transcriptional regulator ttgR ttgR 0.0026
790 DNA polymerase subunit alpha B POLA2 0.0026
663 Solute carrier family 12 member 4 SLC12A4 0.0026
53 Solute carrier family 12 member 5 SLC12A5 0.0026
5300 Antigen peptide transporter 1 TAP1 0.0026
49 Endothelin B receptor EDNRB 0.0026
6859 Protein S100-A4 S100A4 0.0025
1618 High affinity nerve growth factor receptor NTRK1 0.0025
1385 Angiotensin-converting enzyme 2 ACE2 0.0025
5880 Thrombopoietin receptor MPL 0.0025
896 Glutathione S-transferase Mu 1 GSTM1 0.0025
390 Adenosine A3 receptor ADORA3 0.0025
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0025
310 Solute carrier family 12 member 2 SLC12A2 0.0024
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0024
578 Endothelin-1 receptor EDNRA 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
357 Carbonic anhydrase 2 CA2 0.0024
1483 Membrane copper amine oxidase AOC3 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
233 Potassium channel subfamily K member 2 KCNK2 0.0024
6070 Nischarin NISCH 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
1770 Phospholipase C PLCL1 0.0024
2841 Phospholipase C plc 0.0024
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0024
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0024
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0023
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0023
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0023
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0023
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0023
1830 5'-nucleotidase NT5E 0.0023
482 Glycine receptor subunit alpha-1 GLRA1 0.0023
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0023
4311 tRNA TRDMT1 0.0023
4325 tRNA trmD 0.0023
4328 tRNA trmD 0.0023
2599 Tyrosine-protein kinase HCK HCK 0.0022
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0022
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0022
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0022
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0022
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0022
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0022
54 Prothrombin F2 0.0022
4773 Deoxycytidine kinase DCK 0.0022
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0022
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0022
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0022
2021 Thrombomodulin THBD 0.0022
2155 Insulin-degrading enzyme IDE 0.0022
518 Peroxidase/catalase T katG 0.0021
298 Renin REN 0.0021
6163 Copper-transporting ATPase 2 ATP7B 0.0021
6165 Copper-transporting ATPase 1 ATP7A 0.0021
6506 Stathmin-4 STMN4 0.0021
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0021
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0021
2091 Endoplasmin HSP90B1 0.0021
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0021
936 Ephrin type-A receptor 2 EPHA2 0.0021
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.0021
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0021
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0021
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0021
594 Thyroxine-binding globulin SERPINA7 0.0021
4203 Histamine N-methyltransferase HNMT 0.002
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.002
3810 Catechol O-methyltransferase COMT 0.002
4152 Superoxide dismutase [Cu-Zn] SOD1 0.002
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.002
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.002
183 Vascular endothelial growth factor A VEGFA 0.002
5787 Angiopoietin-1 receptor TEK 0.0019
633 Penicillin-binding proteins 1A/1B pbpA 0.0019
461 Glycine receptor subunit alpha-3 GLRA3 0.0019
758 Thyroid hormone receptor alpha THRA 0.0019
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0019
558 Solute carrier family 12 member 1 SLC12A1 0.0019
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0019
976 Platelet glycoprotein IX GP9 0.0018
5626 Nucleoside diphosphate kinase B NME2 0.0018
1374 Natriuretic peptides B NPPB 0.0018
469 Annexin A1 ANXA1 0.0018
1827 Gap junction alpha-1 protein GJA1 0.0018
1908 Vascular cell adhesion protein 1 VCAM1 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
5923 Microtubule-associated protein tau MAPT 0.0018
5924 Microtubule-associated protein 4 MAP4 0.0018
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0018
1063 Signal transducer and activator of transcription 5B STAT5B 0.0018
162 Retinoic acid receptor gamma-1 RARG 0.0018
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0017
484 Tyrosine-protein kinase ABL2 ABL2 0.0017
229 Retinoic acid receptor beta RARB 0.0017
131 Synaptic vesicular amine transporter SLC18A2 0.0017
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0017
346 Thyroid hormone receptor beta-1 THRB 0.0017
563 Thyroid peroxidase TPO 0.0017
730 Retinoic acid receptor alpha RARA 0.0017
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0017
144 Hemoglobin subunit alpha HBA1 0.0017
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0017
106 Cannabinoid receptor 2 CNR2 0.0016
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0016
6174 50S ribosomal protein L32 rpmF 0.0016
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0016
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0016
6042 Prostaglandin reductase 2 PTGR2 0.0016
1243 Cathepsin D CTSD 0.0016
634 Squalene monooxygenase SQLE 0.0016
7196 Squalene monooxygenase ERG1 0.0016
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0016
7 Nitric oxide synthase, inducible NOS2 0.0016
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0016
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0016
537 ATP synthase delta chain, mitochondrial ATP5D 0.0015
3233 Bile acid receptor NR1H4 0.0015
6755 Poliovirus receptor PVR 0.0015
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0015
702 UMP-CMP kinase CMPK1 0.0015
3809 Estrogen-related receptor gamma ESRRG 0.0015
1792 Tissue-type plasminogen activator PLAT 0.0015
3611 Cytidine deaminase cdd 0.0015
3707 Cytidine deaminase cdd 0.0015
4211 Cytidine deaminase CDA 0.0015
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0015
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0015
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0015
1291 cAMP response element-binding protein CREB1 0.0015
3844 HLA class II histocompatibility antigen, DQ(6) alpha chain HLA-DQA2 0.0015
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0015
581 Cytochrome P450 2R1 CYP2R1 0.0015
1525 Heparin-binding growth factor 2 FGF2 0.0015
5294 Nucleoside diphosphate kinase A NME1 0.0015
1569 G1/S-specific cyclin-D1 CCND1 0.0015
1541 Metalloproteinase mmp20 0.0014
4210 Toll-like receptor 4 TLR4 0.0014
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0014
1760 Aminopeptidase N ANPEP 0.0014
6843 Aminopeptidase N pepN 0.0014
2129 Sucrase-isomaltase, intestinal SI 0.0014
153 Dopamine beta-hydroxylase DBH 0.0014
1262 Corticotropin-lipotropin POMC 0.0014
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0014
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0014
1864 RET proto-oncogene RET 0.0013
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0013
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0013
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0013
6211 Tubulin epsilon chain TUBE1 0.0013
6212 Tubulin gamma-1 chain TUBG1 0.0013
6210 Tubulin delta chain TUBD1 0.0013
6228 Nuclear receptor coactivator 1 NCOA1 0.0013
6241 Nuclear receptor coactivator 2 NCOA2 0.0013
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0013
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0013
199 Monocarboxylate transporter 8 SLC16A2 0.0013
444 Alcohol dehydrogenase 1B ADH1B 0.0013
760 Fibroblast growth factor 1 FGF1 0.0013
891 Dihydropteroate synthase folP 0.0013
5359 Dihydropteroate synthase folP 0.0013
7175 Dihydropteroate synthase sulI 0.0013
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0013
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0012
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0012
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0012
6116 Gastric triacylglycerol lipase LIPF 0.0012
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0012
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0012
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0012
1313 Lactoylglutathione lyase GLO1 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
3382 Glycolipid transfer protein GLTP 0.0012
694 Matrix protein 2 M 0.0012
164 Histamine H4 receptor HRH4 0.0012
2240 Cell division protein kinase 2 CDK2 0.0012
85 Growth hormone receptor GHR 0.0012
6126 Carbonic anhydrase 7 CA7 0.0012
2297 Genome polyprotein Not Available 0.0012
2322 Genome polyprotein Not Available 0.0012
2694 Genome polyprotein Not Available 0.0012
2719 Genome polyprotein Not Available 0.0012
2860 Genome polyprotein Not Available 0.0012
2928 Genome polyprotein Not Available 0.0012
3160 Genome polyprotein Not Available 0.0012
3260 Genome polyprotein Not Available 0.0012
4783 Genome polyprotein Not Available 0.0012
5726 Genome polyprotein Not Available 0.0012
5779 Genome polyprotein Not Available 0.0012
5867 Genome polyprotein Not Available 0.0012
6253 Genome polyprotein Not Available 0.0012
6301 Genome polyprotein Not Available 0.0012
6380 Genome polyprotein Not Available 0.0012
6381 Genome polyprotein Not Available 0.0012
6437 Genome polyprotein Not Available 0.0012
6520 Genome polyprotein Not Available 0.0012
6521 Genome polyprotein Not Available 0.0012
6652 Genome polyprotein Not Available 0.0012
6734 Genome polyprotein Not Available 0.0012
6735 Genome polyprotein Not Available 0.0012
6736 Genome polyprotein Not Available 0.0012
6737 Genome polyprotein Not Available 0.0012
6738 Genome polyprotein Not Available 0.0012
6739 Genome polyprotein Not Available 0.0012
6744 Genome polyprotein Not Available 0.0012
6748 Genome polyprotein Not Available 0.0012
6894 Genome polyprotein Not Available 0.0012
6898 Genome polyprotein Not Available 0.0012
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0012
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0012
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0012
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0012
5934 Cytochrome P450 26A1 CYP26A1 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0012
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0012
1295 Fatty acid synthase FASN 0.0012
751 Potassium channel subfamily K member 6 KCNK6 0.0012
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0012
3917 Methylenetetrahydrofolate reductase MTHFR 0.0012
1360 Sphingomyelin phosphodiesterase SMPD1 0.0011
707 72 kDa type IV collagenase MMP2 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0011
3937 Fatty-acid amide hydrolase FAAH 0.0011
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0011
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0011
2300 Lysozyme E 0.0011
3633 Lysozyme R 0.0011
5597 Lysozyme 17 0.0011
6459 Glycodelin PAEP 0.0011
172 Potassium channel subfamily K member 1 KCNK1 0.0011
1630 Integrin beta-2 ITGB2 0.0011
2178 Metabotropic glutamate receptor 5 GRM5 0.0011
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0011
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0011
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0011
251 Alcohol dehydrogenase 1A ADH1A 0.001
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
4116 Dihydropteroate synthetase Not Available 0.001
2216 Fibroblast growth factor receptor 4 FGFR4 0.001
4217 Telomerase reverse transcriptase TERT 0.001
1144 Hepatocyte growth factor receptor MET 0.001
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.001
517 Alcohol dehydrogenase 1C ADH1C 0.001
6100 BDNF/NT-3 growth factors receptor NTRK2 0.001
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
1176 Mitogen-activated protein kinase 1 MAPK1 0.001
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.001
2473 Tyrosine-protein kinase CSK CSK 0.001
2398 Tyrosine-protein kinase ZAP-70 ZAP70 0.001
820 Glycine receptor subunit alpha-2 GLRA2 0.001
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.001
268 Adenosine A2b receptor ADORA2B 0.001
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.001
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.001
2268 Cholesterol oxidase choB 0.0009
2822 Cholesterol oxidase choA 0.0009
174 Sigma 1-type opioid receptor SIGMAR1 0.0009
6048 Troponin C, skeletal muscle TNNC2 0.0009
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0009
3086 Plasmepsin-2 Not Available 0.0009
84 Nuclear receptor 0B1 NR0B1 0.0009
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0009
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0009
1048 Protein S100-A13 S100A13 0.0009
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0009
2226 Protein S100-A12 S100A12 0.0009
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0009
6131 Carbonic anhydrase 14 CA14 0.0009
2283 Steroid Delta-isomerase ksi 0.0009
2920 Steroid Delta-isomerase ksi 0.0009
2298 Cytochrome P450-cam camC 0.0009
208 DNA-directed RNA polymerase beta' chain rpoC 0.0009
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0009
6171 Solute carrier family 28 member 3 SLC28A3 0.0009
2132 Protein S100-B S100B 0.0009
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0008
3404 Exotoxin A eta 0.0008
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
6122 Carbonic anhydrase 3 CA3 0.0008
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0008
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0008
3830 Calreticulin CALR 0.0008
3616 Fatty acid-binding protein, epidermal FABP5 0.0008
5433 UPF0230 protein TM_1468 TM_1468 0.0008
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0008
5431 Lipid binding protein Not Available 0.0008
572 Integrin alpha-L ITGAL 0.0008
5798 Mitogen-activated protein kinase 11 MAPK11 0.0008
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0008
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0008
2320 Thymidine kinase, cytosolic TK1 0.0008
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0008
1867 Major prion protein PRNP 0.0008
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0008
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0008
3221 Cytochrome c4 cc4 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
6034 Hydroxyindole O-methyltransferase ASMT 0.0008
6035 Nuclear receptor ROR-beta RORB 0.0008
6036 Eosinophil peroxidase EPX 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
2530 Protein kinase C theta type PRKCQ 0.0008
1025 Aquaporin-1 AQP1 0.0008
1039 Histone deacetylase 9 HDAC9 0.0008
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0008
400 Coagulation factor IX F9 0.0008
5461 Coagulation factor IX F9 0.0008
473 L-lactate dehydrogenase A chain LDHA 0.0007
4226 Uridine phosphorylase 2 UPP2 0.0007
6103 Arylamine N-acetyltransferase 1 NAT1 0.0007
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0007
2207 Rhodopsin RHO 0.0007
6218 Pannexin-1 PANX1 0.0007
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0007
604 Vitamin K-dependent protein Z PROZ 0.0007
6207 30S ribosomal protein S14 rpsN 0.0007
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0007
6209 30S ribosomal protein S19 rpsS 0.0007
6712 30S ribosomal protein S19 rpsS 0.0007
6726 30S ribosomal protein S19 rpsS 0.0007
283 SEC14-like protein 2 SEC14L2 0.0007
6151 Monocarboxylate transporter 10 SLC16A10 0.0007
645 Penicillin-binding protein 1A mrcA 0.0007
5805 Penicillin-binding protein 1A ponA 0.0007
6185 Penicillin-binding protein 1A mrcA 0.0007
6799 Penicillin-binding protein 1A pbpA 0.0007
2408 Tyrosine-protein kinase SYK SYK 0.0007
3587 Gastrotropin FABP6 0.0007
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0007
2290 ADP-ribosyl cyclase 2 BST1 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
765 Indoleamine 2,3-dioxygenase IDO1 0.0007
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0007
6837 Serine/threonine-protein kinase 17B STK17B 0.0007
4225 Uridine phosphorylase 1 UPP1 0.0007
125 DNA polymerase beta POLB 0.0007
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0007
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0007
2211 Fatty acid-binding protein, heart FABP3 0.0007
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0007
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0006
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0006
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0006
1245 Vitamin K-dependent protein S PROS1 0.0006
413 Amidophosphoribosyltransferase PPAT 0.0006
2515 Amidophosphoribosyltransferase purF 0.0006
3714 Amidophosphoribosyltransferase purF 0.0006
422 Vitamin K-dependent protein C PROC 0.0006
6677 Myelin P2 protein PMP2 0.0006
342 P protein [Includes: DNA-directed DNA polymerase P 0.0006
612 P protein [Includes: DNA-directed DNA polymerase P 0.0006
76 Nitric-oxide synthase, brain NOS1 0.0006
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0006
1196 Complement decay-accelerating factor CD55 0.0006
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0006
3426 Glutamine synthetase glnA 0.0006
3987 Glutamine synthetase GLUL 0.0006
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0006
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0006
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0006
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0006
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0006
6168 Solute carrier family 22 member 16 SLC22A16 0.0006
4943 Cytochrome c6 petJ 0.0006
4954 Soluble cytochrome b558 Not Available 0.0006
4984 Neuroglobin NGB 0.0006
4905 Cytochrome c2 Not Available 0.0006
4939 Cytochrome c2 cycA 0.0006
4964 Cytochrome c2 cycA 0.0006
4979 Cytochrome c2 cycA 0.0006
6673 Cytochrome c2 cycA 0.0006
4994 Hemoglobin-like protein HbO glbO 0.0006
4925 Cytochrome c-type protein SHP shp 0.0006
4934 Cytochrome c-551 nirM 0.0006
5218 Cytochrome c-551 nirM 0.0006
4998 Hemoglobin-like protein yjbI yjbI 0.0006
4947 Bacterial hemoglobin vhb 0.0006
4942 Diheme cytochrome c napB napB 0.0006
4910 Cytoglobin CYGB 0.0006
4936 Cytochrome c2 iso-2 Not Available 0.0006
4916 Cyanoglobin glbN 0.0006
4915 Cytochrome c-550 psbV 0.0006
4959 Cytochrome c-550 psbV 0.0006
5216 Cytochrome c-550 psbV 0.0006
4904 Cytochrome c family protein GSU1996 0.0006
4961 Hemophore HasA hasA 0.0006
4975 Cytochrome c-556 RPA3973 0.0006
644 Heme oxygenase 2 HMOX2 0.0006
4982 Heme oxygenase 2 pbsA2 0.0006
4764 Cytochrome P450 165C4 CYP165C4 0.0006
5000 HemO hemO 0.0006
4971 Nonaheme cytochrome c hmcA 0.0006
4981 Iron-starvation protein PigA pigA 0.0006
4989 Cytochrome c551 peroxidase ccp 0.0006
5222 Cytochrome c551 peroxidase ccpA 0.0006
4976 Apocytochrome f petA 0.0006
6407 Apocytochrome f petA 0.0006
4907 Cytochrome c-L moxG 0.0006
6865 Cytochrome c-L moxG 0.0006
4909 CooA protein cooA 0.0006
4993 Hydroxylamine oxidoreductase hao1 0.0006
4935 Cytochrome c-554 cycA1 0.0006
4931 Cytochrome P450 167A1 CYP167A1 0.0006
4972 P450cin cinA 0.0006
4960 Putative cytochrome P450-family protein SCO7417 0.0006
4937 Cytochrome oxidase subunit II rcoxA 0.0006
4926 Heme-based aerotactic transducer hemAT hemAT 0.0006
4999 Cytochrome P450 165B3 CYP165B3 0.0006
4952 Catalase/peroxidase katA 0.0006
4922 Cytochrome c, putative SO_4144 0.0006
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0006
4903 Methyl-accepting chemotaxis protein Tar4 0.0006
3093 Catalase HPII katE 0.0006
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0006
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0006
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0006
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0006
1721 Glycogen synthase kinase-3 beta GSK3B 0.0005
2808 Chloramphenicol acetyltransferase 3 cat3 0.0005
1341 Histamine H3 receptor HRH3 0.0005
3238 Multidrug resistance protein mexA mexA 0.0005
3116 Bacterioferritin bfr 0.0005
4906 Bacterioferritin bfr 0.0005
4965 Bacterioferritin bfr 0.0005
3173 Enolase eno 0.0005
3709 Glycerol uptake facilitator protein glpF 0.0005
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0005
3393 TGF-beta receptor type-2 TGFBR2 0.0005
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0005
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0005
3639 Thymidine phosphorylase deoA 0.0005
3936 Thymidine phosphorylase TYMP 0.0005
798 Osteocalcin BGLAP 0.0005
2183 Fatty acid-binding protein, adipocyte FABP4 0.0005
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0005
2417 Chloramphenicol acetyltransferase cat 0.0005
3278 Chloramphenicol acetyltransferase cat 0.0005
2810 Dr hemagglutinin structural subunit draA 0.0005
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0005
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0005
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0005
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0005
2852 DNA mismatch repair protein mutL mutL 0.0005
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0005
369 Coagulation factor VII F7 0.0005
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0005
3913 Glutamic acid decarboxylase GAD65 0.0005
3191 Histidinol dehydrogenase hisD 0.0005
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0004
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0004
1992 Vitamin D-binding protein GC 0.0004
4920 Peroxidase/catalase katG 0.0004
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0004
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0004
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0004
4923 Cytochrome c3 DvMF_2499 0.0004
4945 Cytochrome c3 Not Available 0.0004
4949 Cytochrome c3 DVU_3171 0.0004
4968 Cytochrome c3 cytc3 0.0004
4997 Cytochrome c3 SO_2727 0.0004
5219 Cytochrome c3 cyd 0.0004
4948 Cytochrome c-553 Not Available 0.0004
2119 Cytochrome b5 CYB5A 0.0004
4037 Hypothetical protein GPX1 0.0004
4297 Hypothetical protein SP_1951 0.0004
4521 Hypothetical protein BC_2969 0.0004
4540 Hypothetical protein TM_1070 0.0004
4555 Hypothetical protein MT1739 0.0004
4569 Hypothetical protein mshD 0.0004
4578 Hypothetical protein PA3270 0.0004
4747 Hypothetical protein PA3967 0.0004
5177 Hypothetical protein TM_0096 0.0004
5194 Hypothetical protein PA1204 0.0004
5240 Hypothetical protein Rv2991 0.0004
5370 Hypothetical protein TM_1158 0.0004
5710 Hypothetical protein Tb927.5.1360 0.0004
3189 High-molecular-weight cytochrome c hmcA 0.0004
4902 Nine-heme cytochrome c Ddes_2038 0.0004
4990 PpcA ppcA 0.0004
4289 Cytochrome P450 TT_P0059 0.0004
6262 Cytochrome P450 staP 0.0004
4992 Cytochrome c peroxidase Not Available 0.0004
3570 Cytochrome P450 152A1 cypC 0.0004
4988 Sulfite oxidase, mitochondrial SUOX 0.0004
2915 Sensor protein fixL fixL 0.0004
4944 Sensor protein fixL fixL 0.0004
3375 Acidic cytochrome c3 Not Available 0.0004
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0004
4813 Heme oxygenase hmuO 0.0004
5769 Heme oxygenase Not Available 0.0004
4385 Cytochrome c' Not Available 0.0004
4967 Cytochrome c' cycA 0.0004
5038 Cytochrome c' Not Available 0.0004
5223 Cytochrome c' cycP 0.0004
4692 A/G-specific adenine glycosylase mutY 0.0004
2230 Catalase CAT 0.0004
3249 Catalase katA 0.0004
3625 Catalase katA 0.0004
4539 Catalase katA 0.0004
4941 Catalase katB 0.0004
5818 Folate receptor alpha FOLR1 0.0004
735 Alanine aminotransferase 1 GPT 0.0004
3904 Alanine aminotransferase 2 GPT2 0.0004
3670 Soluble cytochrome b562 precursor cybC 0.0004
3411 Cytochrome P450 121 cyp121 0.0004
2802 Endoglucanase G celCCG 0.0004
340 Apoptotic protease-activating factor 1 APAF1 0.0004
2617 Nitric oxide synthase oxygenase nos 0.0004
2701 Nitric oxide synthase oxygenase nos 0.0004
3291 Cytochrome c-552 cycA 0.0004
4927 Cytochrome c-552 nrfA 0.0004
4938 Cytochrome c-552 cycA 0.0004
4953 Cytochrome c-552 nrfA 0.0004
5217 Cytochrome c-552 cycM 0.0004
4386 Hemoglobin-like protein HbN glbN 0.0004
3102 Flavohemoprotein hmp 0.0004
4969 Flavohemoprotein hmp 0.0004
2391 Ferrochelatase hemH 0.0004
6502 Ferrochelatase DKFZp686P18130 0.0004
1591 Ferrochelatase, mitochondrial FECH 0.0004
6316 ADP-ribosylation factor 1 ARF1 0.0004
719 Retinoic acid receptor responder protein 1 RARRES1 0.0003
770 Retinoic acid-induced protein 3 GPRC5A 0.0003
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0003
3127 Nitrite reductase nirS 0.0003
3284 Nitrite reductase nirS 0.0003
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0003
2972 6-deoxyerythronolide B hydroxylase eryF 0.0003
293 Gamma-glutamyl hydrolase GGH 0.0003
825 Arsenical pump-driving ATPase ASNA1 0.0003
3435 Arsenical pump-driving ATPase arsA 0.0003
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0003
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0003
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0003
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0003
733 Activin receptor type 1B ACVR1B 0.0003
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0003
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0003
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0003
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0003
154 AFG3-like protein 2 AFG3L2 0.0003
395 ALK tyrosine kinase receptor Not Available 0.0003
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0003
6493 Cytochrome c oxidase subunit 6C COX6C 0.0003
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0003
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0003
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0003
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0003
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0003
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0003
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0003
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0003
6559 Cytochrome c oxidase subunit 2 ctaC 0.0003
6669 Cytochrome c oxidase subunit 2 ctaC 0.0003
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0003
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0003
6558 Cytochrome c oxidase subunit 1 ctaD 0.0003
4608 Putative cytochrome P450 SCO1207 0.0003
4963 Putative cytochrome P450 SCO2884 0.0003
6254 Putative cytochrome P450 SCO6998 0.0003
292 Activin receptor type-1 ACVR1 0.0003
849 Activated CDC42 kinase 1 TNK2 0.0003
569 Retinal dehydrogenase 2 ALDH1A2 0.0003
358 Cystathionine beta-synthase CBS 0.0003
267 Plasminogen activator inhibitor 1 SERPINE1 0.0003
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0003
2540 Choloylglycine hydrolase cbh 0.0003
1507 Cytochrome c CYCS 0.0003
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0003
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0003
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0003
297 Adenylate cyclase type 1 ADCY1 0.0003
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0003
693 Hemoglobin subunit beta HBB 0.0003
611 Retinal dehydrogenase 1 ALDH1A1 0.0003
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0003
1268 Neuropeptide S receptor NPSR1 0.0003
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0003
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0003
6501 Fatty acid-binding protein, liver FABP1 0.0003
6221 Steroid hormone receptor ERR1 ESRRA 0.0003
6268 Hydroxyacid oxidase 1 HAO1 0.0003
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0003
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0003
810 Heme oxygenase 1 HMOX1 0.0003
3391 Heme oxygenase 1 pbsA1 0.0003
6073 Potassium channel subfamily K member 9 KCNK9 0.0003
6072 Potassium channel subfamily K member 3 KCNK3 0.0003
740 Argininosuccinate synthase ASS1 0.0002
865 Argininosuccinate synthase ASS1 0.0002
2680 Argininosuccinate synthase argG 0.0002
3194 Argininosuccinate synthase argG 0.0002
6021 Adenosine kinase ADK 0.0002
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0002
6135 Sodium channel subunit beta-4 SCN4B 0.0002
6134 Sodium channel subunit beta-3 SCN3B 0.0002
6132 Sodium channel subunit beta-1 SCN1B 0.0002
6127 Carbonic anhydrase-related protein CA8 0.0002
6128 Carbonic anhydrase-related protein 10 CA10 0.0002
6133 Sodium channel subunit beta-2 SCN2B 0.0002
6129 Carbonic anhydrase-related protein 11 CA11 0.0002
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0002
6130 Carbonic anhydrase 13 CA13 0.0002
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0002
3007 Carbonic anhydrase 12 CA12 0.0002
4205 Carbonic anhydrase 9 CA9 0.0002
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