DT-Web

DB06725 - Lornoxicam


Identification
Name Lornoxicam
Accession Number DB06725
Type small molecule
Description Lornoxicam (chlortenoxicam) is a new nonsteroidal anti-inflammatory drug (NSAID) of the oxicam class with analgesic, anti-inflammatory and antipyretic properties. Lornoxicam differs from other oxicam compounds in its potent inhibition of prostaglandin biosynthesis, a property that explains the particularly pronounced efficacy of the drug. Lornoxicam is approved for use in Japan.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 371.819
Groups approved
Monoisotopic Weight 370.98012491
Pharmacology
Indication For the treatment of acute mild to moderate pain, as well as pain and inflammation of the joints caused by certain types of rheumatic diseases.
Mechanism of action Like other NSAIDS, lornoxicam's anti-inflammatory and analgesic activity is related to its inhibitory action on prostaglandin and thromboxane synthesis through the inhibition of both COX-1 and COX-2. This leads to the reduction of inflammation, pain, fever, and swelling, which are mediated by prostaglandins. However, the exact mechanism of lornoxicam, like that of the other NSAIDs, has not been fully determined.
Absorption Lornoxicam is absorbed rapidly and almost completely from the GI tract (90-100%).
Protein binding Lornoxicam is 99% bound to plasma proteins (almost exlusively to serum albumin).
Biotransformation Lornoxicam is metabolized completely by cyp 2C9 with the principal metabolite being 5'-hydroxy-lornoxicam and only negligible amounts of intact lornoxicam are excreted unchanged in the urine. Approximately 2/3 of the drug is eliminated via the liver and 1/3 via the kidneys in the active form.
Route of elimination Not Available
Toxicity Not Available
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Prostaglandin G/H synthase 1
Name Prostaglandin G/H synthase 1
Gene Name PTGS1
Pharmacological action yes
Actions inhibitor
References
  • Renner RM, Jensen JT, Nichols MD, Edelman AB: Pain control in first-trimester surgical abortion: a systematic review of randomized controlled trials. Contraception. 2010 May;81(5):372-88. Epub 2010 Jan 27. - Pubmed
  • Berg J, Fellier H, Christoph T, Grarup J, Stimmeder D: The analgesic NSAID lornoxicam inhibits cyclooxygenase (COX)-1/-2, inducible nitric oxide synthase (iNOS), and the formation of interleukin (IL)-6 in vitro. Inflamm Res. 1999 Jul;48(7):369-79. - Pubmed
  • Rose P, Steinhauser C: Comparison of Lornoxicam and Rofecoxib in Patients with Activated Osteoarthritis (COLOR Study). Clin Drug Investig. 2004;24(4):227-36. - Pubmed
  • Bianchi M, Panerai AE: Effects of lornoxicam, piroxicam, and meloxicam in a model of thermal hindpaw hyperalgesia induced by formalin injection in rat tail. Pharmacol Res. 2002 Feb;45(2):101-5. - Pubmed
DTHybrid score 0.5781
Prostaglandin G/H synthase 2
Name Prostaglandin G/H synthase 2
Gene Name PTGS2
Pharmacological action yes
Actions inhibitor
References
  • Renner RM, Jensen JT, Nichols MD, Edelman AB: Pain control in first-trimester surgical abortion: a systematic review of randomized controlled trials. Contraception. 2010 May;81(5):372-88. Epub 2010 Jan 27. - Pubmed
  • Berg J, Fellier H, Christoph T, Grarup J, Stimmeder D: The analgesic NSAID lornoxicam inhibits cyclooxygenase (COX)-1/-2, inducible nitric oxide synthase (iNOS), and the formation of interleukin (IL)-6 in vitro. Inflamm Res. 1999 Jul;48(7):369-79. - Pubmed
  • Rose P, Steinhauser C: Comparison of Lornoxicam and Rofecoxib in Patients with Activated Osteoarthritis (COLOR Study). Clin Drug Investig. 2004;24(4):227-36. - Pubmed
  • Bianchi M, Panerai AE: Effects of lornoxicam, piroxicam, and meloxicam in a model of thermal hindpaw hyperalgesia induced by formalin injection in rat tail. Pharmacol Res. 2002 Feb;45(2):101-5. - Pubmed
DTHybrid score 0.5173

Enzymes


Cytochrome P450 2C9
Name Cytochrome P450 2C9
Gene Name CYP2C9
Actions substrate,inhibitor
References
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Rodrigues AD: Impact of CYP2C9 genotype on pharmacokinetics: are all cyclooxygenase inhibitors the same? Drug Metab Dispos. 2005 Nov;33(11):1567-75. Epub 2005 Aug 23. - Pubmed
  • Martinez C, Blanco G, Garcia-Martin E, Agundez JA: [Clinical pharmacogenomics for CYP2C8 and CYP2C9: general concepts and application to the use of NSAIDs] Farm Hosp. 2006 Jul-Aug;30(4):240-8. - Pubmed
  • Zhang Y, Zhong D, Si D, Guo Y, Chen X, Zhou H: Lornoxicam pharmacokinetics in relation to cytochrome P450 2C9 genotype. Br J Clin Pharmacol. 2005 Jan;59(1):14-7. - Pubmed
  • Kohl C, Steinkellner M: Prediction of pharmacokinetic drug/drug interactions from In vitro data: interactions of the nonsteroidal anti-inflammatory drug lornoxicam with oral anticoagulants. Drug Metab Dispos. 2000 Feb;28(2):161-8. - Pubmed
  • Bonnabry P, Leemann T, Dayer P: Role of human liver microsomal CYP2C9 in the biotransformation of lornoxicam. Eur J Clin Pharmacol. 1996;49(4):305-8. - Pubmed
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.2868

Predictions


Id Partner name Gene Name Score
4512 Cytochrome P450 3A4 CYP3A4 0.1177
4924 Cytochrome P450 2C8 CYP2C8 0.1086
6016 Cytochrome P450 2C19 CYP2C19 0.1085
4200 Cytochrome P450 1A2 CYP1A2 0.0849
587 Serum albumin ALB 0.0699
1729 Solute carrier family 22 member 6 SLC22A6 0.0693
4119 Cytochrome P450 2D6 CYP2D6 0.068
1588 Multidrug resistance protein 1 ABCB1 0.0479
275 Arachidonate 5-lipoxygenase ALOX5 0.0471
6013 Cytochrome P450 2E1 CYP2E1 0.0462
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0449
6030 Cytochrome P450 2B6 CYP2B6 0.0409
4118 Cytochrome P450 3A5 CYP3A5 0.0385
1757 Myeloperoxidase MPO 0.0328
5718 Cytochrome P450 2A6 CYP2A6 0.0306
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.029
6142 Solute carrier family 22 member 8 SLC22A8 0.0288
6024 Cytochrome P450 1A1 CYP1A1 0.0283
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0282
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0273
2164 Multidrug resistance-associated protein 4 ABCC4 0.0269
6107 Cytochrome P450 3A7 CYP3A7 0.026
1024 Solute carrier family 22 member 11 SLC22A11 0.0225
6106 Cytochrome P450 2C18 CYP2C18 0.0217
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0208
3312 Fatty acid-binding protein, brain FABP7 0.0199
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0198
1159 Interleukin-6 IL6 0.0185
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0174
373 Transthyretin TTR 0.0166
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0163
6143 Solute carrier family 22 member 7 SLC22A7 0.0162
3923 Cholinesterase BCHE 0.0159
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0144
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0143
777 Tumor necrosis factor TNF 0.0135
672 Prostaglandin F2-alpha receptor PTGFR 0.0135
703 NADPH azoreductase azr 0.0132
862 Multidrug resistance-associated protein 1 ABCC1 0.0128
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0126
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0124
850 Vasopressin V1b receptor AVPR1B 0.0122
891 Dihydropteroate synthase folP 0.0121
5359 Dihydropteroate synthase folP 0.0121
7175 Dihydropteroate synthase sulI 0.0121
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0121
146 Androgen receptor AR 0.0121
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0118
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0117
1507 Cytochrome c CYCS 0.0116
70 Type-1 angiotensin II receptor AGTR1 0.0114
6220 Aryl hydrocarbon receptor AHR 0.0114
853 Farnesyl pyrophosphate synthetase FDPS 0.0113
492 Histamine H1 receptor HRH1 0.011
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0108
185 Vasopressin V1a receptor AVPR1A 0.0107
6012 Tryptophan 2,3-dioxygenase TDO2 0.0106
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0106
322 Vasopressin V2 receptor AVPR2 0.0105
738 Monocarboxylate transporter 1 SLC16A1 0.0105
6102 Arylamine N-acetyltransferase 2 NAT2 0.0103
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0102
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0102
130 Prostacyclin synthase PTGIS 0.0102
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0101
3811 Cytochrome P450 19A1 CYP19A1 0.01
1439 Lactotransferrin LTF 0.0098
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0098
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0097
1648 Elastin ELN 0.0097
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0096
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0096
1898 Cytochrome P450 1B1 CYP1B1 0.0095
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0094
4132 Chloride channel protein ClC-Ka CLCNKA 0.009
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0088
782 ADP/ATP translocase 2 SLC25A5 0.0086
688 ADP/ATP translocase 3 SLC25A6 0.0086
723 Cytosolic phospholipase A2 PLA2G4A 0.0083
3947 Xanthine dehydrogenase/oxidase XDH 0.0082
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0081
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.008
61 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0079
2644 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0079
2710 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0079
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0079
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0079
6043 Putative G-protein coupled receptor 44 GPR44 0.0078
824 Sodium-dependent serotonin transporter SLC6A4 0.0077
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0077
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0076
4221 Vascular endothelial growth factor VEGF 0.0075
5816 Cadherin-5 CDH5 0.0075
122 P2Y purinoceptor 12 P2RY12 0.0075
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0074
6085 Fatty acid-binding protein, intestinal FABP2 0.0074
136 Estrogen receptor ESR1 0.0073
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0073
811 Translocator protein TSPO 0.0072
6137 Multidrug resistance-associated protein 6 ABCC6 0.0072
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.007
6145 Solute carrier family 22 member 1 SLC22A1 0.0069
558 Solute carrier family 12 member 1 SLC12A1 0.0068
6033 High affinity interleukin-8 receptor A CXCR1 0.0067
6144 Solute carrier family 22 member 2 SLC22A2 0.0066
661 ADP/ATP translocase 1 SLC25A4 0.0064
459 Retinoic acid receptor RXR-alpha RXRA 0.0064
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0064
133 Dihydropterate synthase sulI 0.0063
4116 Dihydropteroate synthetase Not Available 0.0062
502 5-hydroxytryptamine 2A receptor HTR2A 0.0062
1275 Estrogen sulfotransferase SULT1E1 0.0062
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0061
3823 Cytokine receptor common gamma chain IL2RG 0.0061
1656 CYP2B protein CYP2B 0.006
134 Tryptophan 5-hydroxylase 1 TPH1 0.006
823 Fibroblast growth factor receptor 2 FGFR2 0.006
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0059
341 5-hydroxytryptamine 3 receptor HTR3A 0.0058
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0058
6500 Phospholipase A2 PLA2G1B 0.0057
759 Free fatty acid receptor 1 FFAR1 0.0056
1818 Long-chain-fatty-acid--CoA ligase 3 ACSL3 0.0056
489 Monocarboxylate transporter 2 SLC16A7 0.0056
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0056
260 Cytochrome P450 51 ERG11 0.0056
761 Cytochrome P450 51 ERG11 0.0056
3163 Cytochrome P450 51 cyp51 0.0056
828 Phenylalanine-4-hydroxylase PAH 0.0054
3109 Phenylalanine-4-hydroxylase phhA 0.0054
614 Progesterone receptor PGR 0.0054
676 Tyrosine 3-monooxygenase TH 0.0054
831 D(2) dopamine receptor DRD2 0.0053
731 HIV-1 protease HIV-1 protease 0.0053
724 Interleukin-2 receptor alpha chain IL2RA 0.0053
717 Interleukin-2 receptor subunit beta IL2RB 0.0053
6149 Solute carrier family 22 member 10 SLC22A10 0.0053
2853 14 kDa fatty acid-binding protein Not Available 0.0053
3808 Dihydropteroate synthase 2 folP2 0.0052
3601 Dihydropteroate synthase 1 folP1 0.0052
3807 Dihydropteroate synthase 1 folP1 0.0052
737 Mineralocorticoid receptor NR3C2 0.0051
118 Organic cation/carnitine transporter 2 SLC22A5 0.0051
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0051
6141 Sodium/bile acid cotransporter SLC10A1 0.0051
427 Substance-P receptor TACR1 0.0051
776 Bile salt export pump ABCB11 0.0051
696 Kappa-type opioid receptor OPRK1 0.005
1714 Mitogen-activated protein kinase 3 MAPK3 0.005
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.005
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.005
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0049
847 Mu-type opioid receptor OPRM1 0.0049
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0049
1053 BC269730_2 FADS1 0.0049
1395 Sodium/calcium exchanger 1 SLC8A1 0.0049
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0049
467 Delta-type opioid receptor OPRD1 0.0049
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0047
2981 Phospholipase A2, membrane associated PLA2G2A 0.0047
1558 Transient receptor potential cation channel subfamily V member 1 TRPV1 0.0046
3810 Catechol O-methyltransferase COMT 0.0046
33 Cystine/glutamate transporter SLC7A11 0.0045
1650 Heme carrier protein 1 SLC46A1 0.0045
527 Prostacyclin receptor PTGIR 0.0045
7 Nitric oxide synthase, inducible NOS2 0.0045
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0045
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0045
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0044
817 DNA topoisomerase 2-alpha TOP2A 0.0044
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0044
713 Sodium-dependent dopamine transporter SLC6A3 0.0044
556 Alpha-1A adrenergic receptor ADRA1A 0.0044
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0044
49 Endothelin B receptor EDNRB 0.0044
3941 Amine oxidase [flavin-containing] A MAOA 0.0043
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0043
291 Nitric-oxide synthase, endothelial NOS3 0.0043
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0042
2236 Casein kinase II subunit alpha CSNK2A1 0.0042
468 Cytochrome P450 4A11 CYP4A11 0.0041
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0041
578 Endothelin-1 receptor EDNRA 0.0041
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0041
6103 Arylamine N-acetyltransferase 1 NAT1 0.0041
3939 Amine oxidase [flavin-containing] B MAOB 0.0041
590 5-hydroxytryptamine 2C receptor HTR2C 0.004
103 Muscarinic acetylcholine receptor M1 CHRM1 0.004
232 Corticosteroid-binding globulin SERPINA6 0.0039
6136 Multidrug resistance-associated protein 5 ABCC5 0.0039
4604 Liver carboxylesterase 1 CES1 0.0038
766 Beta-2 adrenergic receptor ADRB2 0.0038
908 Glutathione S-transferase theta-1 GSTT1 0.0038
320 5-hydroxytryptamine 1A receptor HTR1A 0.0038
1789 Lymphotoxin-alpha LTA 0.0037
1269 Tumor necrosis factor receptor superfamily member 1B TNFRSF1B 0.0037
2183 Fatty acid-binding protein, adipocyte FABP4 0.0037
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0037
295 Carbonic anhydrase 1 CA1 0.0036
183 Vascular endothelial growth factor A VEGFA 0.0036
1192 Sulfotransferase 1A1 SULT1A1 0.0036
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0036
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0036
6146 High affinity copper uptake protein 1 SLC31A1 0.0036
822 Aldose reductase AKR1B1 0.0036
871 Glucocorticoid receptor NR3C1 0.0036
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0036
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0036
6148 Multidrug resistance-associated protein 7 ABCC10 0.0035
6014 Cytochrome P450 2A13 CYP2A13 0.0035
592 Carbonic anhydrase 4 CA4 0.0035
106 Cannabinoid receptor 2 CNR2 0.0035
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0035
1629 Transcription factor AP-1 JUN 0.0034
2021 Thrombomodulin THBD 0.0034
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0034
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0034
68 Cannabinoid receptor 1 CNR1 0.0033
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0033
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0033
6031 Cytochrome P450 3A43 CYP3A43 0.0033
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0033
4784 Beta-mannosidase manB 0.0032
6695 Beta-mannosidase BT_0458 0.0032
365 Dihydrofolate reductase DHFR 0.0032
2381 Dihydrofolate reductase DFR1 0.0032
2833 Dihydrofolate reductase Not Available 0.0032
2931 Dihydrofolate reductase folA 0.0032
3544 Dihydrofolate reductase folA 0.0032
3682 Dihydrofolate reductase folA 0.0032
6642 Dihydrofolate reductase folA 0.0032
6756 Dihydrofolate reductase dfrA 0.0032
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0032
632 Alpha-1B adrenergic receptor ADRA1B 0.0031
634 Squalene monooxygenase SQLE 0.0031
7196 Squalene monooxygenase ERG1 0.0031
904 Glutathione S-transferase P GSTP1 0.0031
1227 Cytochrome b MT-CYB 0.0031
6386 Cytochrome b petB 0.0031
6937 Cytochrome b MT-CYB 0.0031
674 Dihydroorotate dehydrogenase homolog, mitochondrial PFF0160c 0.0031
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.003
465 Calmodulin CALM1 0.003
318 Alpha-2A adrenergic receptor ADRA2A 0.003
1050 Bile salt sulfotransferase SULT2A1 0.003
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.003
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.003
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0029
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0029
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0029
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0029
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0029
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0028
2998 Sialic acid-binding Ig-like lectin 7 SIGLEC7 0.0028
273 Apoptosis regulator Bcl-2 BCL2 0.0028
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0028
1200 AMBP protein AMBP 0.0028
3866 Serum amyloid A protein SAA1 0.0028
1932 Apolipoprotein E APOE 0.0028
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0027
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0027
2159 Quinone oxidoreductase CRYZ 0.0027
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0027
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0027
24 Thymidylate synthase TMP1 0.0027
359 Thymidylate synthase TYMS 0.0027
2626 Thymidylate synthase thyA 0.0027
2729 Thymidylate synthase thyA 0.0027
5352 Thymidylate synthase THYA 0.0027
504 Mast/stem cell growth factor receptor KIT 0.0027
23 D(1A) dopamine receptor DRD1 0.0027
54 Prothrombin F2 0.0026
571 Melatonin receptor type 1A MTNR1A 0.0026
362 Melatonin receptor type 1B MTNR1B 0.0026
6147 Solute carrier family 22 member 3 SLC22A3 0.0026
663 Solute carrier family 12 member 4 SLC12A4 0.0026
53 Solute carrier family 12 member 5 SLC12A5 0.0026
357 Carbonic anhydrase 2 CA2 0.0026
6126 Carbonic anhydrase 7 CA7 0.0026
6042 Prostaglandin reductase 2 PTGR2 0.0026
436 5-hydroxytryptamine 2B receptor HTR2B 0.0025
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0025
789 Alpha-1D adrenergic receptor ADRA1D 0.0025
4787 Envelope glycoprotein gp160 env 0.0025
4820 Envelope glycoprotein gp160 env 0.0025
5727 Envelope glycoprotein gp160 env 0.0025
1541 Metalloproteinase mmp20 0.0025
4192 DNA topoisomerase 2-beta TOP2B 0.0025
528 5-hydroxytryptamine 1E receptor HTR1E 0.0025
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0024
310 Solute carrier family 12 member 2 SLC12A2 0.0024
482 Glycine receptor subunit alpha-1 GLRA1 0.0024
3814 Complement C1r subcomponent C1R 0.0024
1792 Tissue-type plasminogen activator PLAT 0.0024
2297 Genome polyprotein Not Available 0.0024
2322 Genome polyprotein Not Available 0.0024
2694 Genome polyprotein Not Available 0.0024
2719 Genome polyprotein Not Available 0.0024
2860 Genome polyprotein Not Available 0.0024
2928 Genome polyprotein Not Available 0.0024
3160 Genome polyprotein Not Available 0.0024
3260 Genome polyprotein Not Available 0.0024
4783 Genome polyprotein Not Available 0.0024
5726 Genome polyprotein Not Available 0.0024
5779 Genome polyprotein Not Available 0.0024
5867 Genome polyprotein Not Available 0.0024
6253 Genome polyprotein Not Available 0.0024
6301 Genome polyprotein Not Available 0.0024
6380 Genome polyprotein Not Available 0.0024
6381 Genome polyprotein Not Available 0.0024
6437 Genome polyprotein Not Available 0.0024
6520 Genome polyprotein Not Available 0.0024
6521 Genome polyprotein Not Available 0.0024
6652 Genome polyprotein Not Available 0.0024
6734 Genome polyprotein Not Available 0.0024
6735 Genome polyprotein Not Available 0.0024
6736 Genome polyprotein Not Available 0.0024
6737 Genome polyprotein Not Available 0.0024
6738 Genome polyprotein Not Available 0.0024
6739 Genome polyprotein Not Available 0.0024
6744 Genome polyprotein Not Available 0.0024
6748 Genome polyprotein Not Available 0.0024
6894 Genome polyprotein Not Available 0.0024
6898 Genome polyprotein Not Available 0.0024
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0024
885 5-hydroxytryptamine 1B receptor HTR1B 0.0024
94 5-hydroxytryptamine 4 receptor HTR4 0.0023
4103 Proteasome subunit beta type 2 PSMB2 0.0023
4102 Proteasome subunit beta type 5 PSMB5 0.0023
4101 Proteasome subunit beta type 1 PSMB1 0.0023
6182 Cytochrome P450 2J2 CYP2J2 0.0023
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0023
921 Glutamate receptor 2 GRIA2 0.0023
2782 Complement C1s subcomponent C1S 0.0022
1374 Natriuretic peptides B NPPB 0.0022
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0022
1827 Gap junction alpha-1 protein GJA1 0.0022
1908 Vascular cell adhesion protein 1 VCAM1 0.0022
3480 Mannan endo-1,4-beta-mannosidase manA 0.0022
407 Vascular endothelial growth factor receptor 2 KDR 0.0021
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0021
716 5-hydroxytryptamine 7 receptor HTR7 0.0021
3437 Eosinophil lysophospholipase CLC 0.0021
780 Retinoic acid receptor RXR-gamma RXRG 0.0021
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0021
4203 Histamine N-methyltransferase HNMT 0.0021
511 5-hydroxytryptamine 1F receptor HTR1F 0.0021
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0021
1618 High affinity nerve growth factor receptor NTRK1 0.0021
3817 Complement C1q subcomponent subunit C C1QC 0.0021
3815 Complement C1q subcomponent subunit A C1QA 0.0021
3816 Complement C1q subcomponent subunit B C1QB 0.0021
1102 Low affinity immunoglobulin gamma Fc region receptor III-B FCGR3B 0.0021
3818 Low affinity immunoglobulin gamma Fc region receptor III-A FCGR3A 0.0021
3819 Low affinity immunoglobulin gamma Fc region receptor II-a FCGR2A 0.0021
3821 Low affinity immunoglobulin gamma Fc region receptor II-c FCGR2C 0.0021
3820 Low affinity immunoglobulin gamma Fc region receptor II-b FCGR2B 0.002
2207 Rhodopsin RHO 0.002
153 Dopamine beta-hydroxylase DBH 0.002
1313 Lactoylglutathione lyase GLO1 0.002
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.002
228 Beta platelet-derived growth factor receptor PDGFRB 0.002
784 High affinity immunoglobulin gamma Fc receptor I FCGR1A 0.0019
193 Beta-1 adrenergic receptor ADRB1 0.0019
88 Retinoic acid receptor RXR-beta RXRB 0.0019
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0019
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0019
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0019
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0019
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0019
3639 Thymidine phosphorylase deoA 0.0019
3936 Thymidine phosphorylase TYMP 0.0019
725 5-hydroxytryptamine 1D receptor HTR1D 0.0019
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0019
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0019
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0019
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0019
6131 Carbonic anhydrase 14 CA14 0.0019
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0018
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0018
869 Estrogen receptor beta ESR2 0.0018
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0018
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0018
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0017
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0017
1144 Hepatocyte growth factor receptor MET 0.0017
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0017
518 Peroxidase/catalase T katG 0.0017
992 Protein tyrosine kinase 2 beta PTK2B 0.0017
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0017
1864 RET proto-oncogene RET 0.0017
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0016
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0016
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0016
6163 Copper-transporting ATPase 2 ATP7B 0.0016
6165 Copper-transporting ATPase 1 ATP7A 0.0016
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0016
4785 Ig gamma-1 chain C region IGHG1 0.0015
4120 NADPH--cytochrome P450 reductase POR 0.0015
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0015
380 Cytochrome P450 17A1 CYP17A1 0.0015
208 DNA-directed RNA polymerase beta' chain rpoC 0.0015
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0015
833 Organic cation/carnitine transporter 1 SLC22A4 0.0015
1039 Histone deacetylase 9 HDAC9 0.0015
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0015
3611 Cytidine deaminase cdd 0.0014
3707 Cytidine deaminase cdd 0.0014
4211 Cytidine deaminase CDA 0.0014
1010 Cytochrome P450 51A1 CYP51A1 0.0014
756 Sex hormone-binding globulin SHBG 0.0014
629 Alpha-2B adrenergic receptor ADRA2B 0.0014
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0014
2232 Interleukin-5 IL5 0.0014
1593 Mucin-2 MUC2 0.0014
4948 Cytochrome c-553 Not Available 0.0014
4923 Cytochrome c3 DvMF_2499 0.0014
4945 Cytochrome c3 Not Available 0.0014
4949 Cytochrome c3 DVU_3171 0.0014
4968 Cytochrome c3 cytc3 0.0014
4997 Cytochrome c3 SO_2727 0.0014
5219 Cytochrome c3 cyd 0.0014
3189 High-molecular-weight cytochrome c hmcA 0.0014
4902 Nine-heme cytochrome c Ddes_2038 0.0014
844 Epidermal growth factor receptor EGFR 0.0013
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0013
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0013
896 Glutathione S-transferase Mu 1 GSTM1 0.0013
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0013
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0013
124 Histamine H2 receptor HRH2 0.0012
29 Tubulin beta-1 chain TUBB1 0.0012
4386 Hemoglobin-like protein HbN glbN 0.0012
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0012
474 Acetylcholinesterase ACHE 0.0011
164 Histamine H4 receptor HRH4 0.0011
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0011
1123 Eosinophil cationic protein RNASE3 0.0011
638 D(3) dopamine receptor DRD3 0.0011
432 D(4) dopamine receptor DRD4 0.0011
6174 50S ribosomal protein L32 rpmF 0.0011
4238 50S ribosomal protein L4 rplD 0.0011
5578 50S ribosomal protein L4 rplD 0.0011
6173 50S ribosomal protein L4 rplD 0.0011
6219 50S ribosomal protein L4 rplD 0.0011
3221 Cytochrome c4 cc4 0.0011
1196 Complement decay-accelerating factor CD55 0.001
3809 Estrogen-related receptor gamma ESRRG 0.001
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.001
4943 Cytochrome c6 petJ 0.001
4954 Soluble cytochrome b558 Not Available 0.001
4934 Cytochrome c-551 nirM 0.001
5218 Cytochrome c-551 nirM 0.001
4905 Cytochrome c2 Not Available 0.001
4939 Cytochrome c2 cycA 0.001
4964 Cytochrome c2 cycA 0.001
4979 Cytochrome c2 cycA 0.001
6673 Cytochrome c2 cycA 0.001
4984 Neuroglobin NGB 0.001
4925 Cytochrome c-type protein SHP shp 0.001
4947 Bacterial hemoglobin vhb 0.001
4994 Hemoglobin-like protein HbO glbO 0.001
4916 Cyanoglobin glbN 0.001
4998 Hemoglobin-like protein yjbI yjbI 0.001
4942 Diheme cytochrome c napB napB 0.001
4915 Cytochrome c-550 psbV 0.001
4959 Cytochrome c-550 psbV 0.001
5216 Cytochrome c-550 psbV 0.001
4975 Cytochrome c-556 RPA3973 0.001
4961 Hemophore HasA hasA 0.001
4936 Cytochrome c2 iso-2 Not Available 0.001
4910 Cytoglobin CYGB 0.001
644 Heme oxygenase 2 HMOX2 0.001
4982 Heme oxygenase 2 pbsA2 0.001
5000 HemO hemO 0.001
4981 Iron-starvation protein PigA pigA 0.001
4904 Cytochrome c family protein GSU1996 0.001
4907 Cytochrome c-L moxG 0.001
6865 Cytochrome c-L moxG 0.001
4909 CooA protein cooA 0.001
4976 Apocytochrome f petA 0.001
6407 Apocytochrome f petA 0.001
3116 Bacterioferritin bfr 0.001
4906 Bacterioferritin bfr 0.001
4965 Bacterioferritin bfr 0.001
4971 Nonaheme cytochrome c hmcA 0.001
4764 Cytochrome P450 165C4 CYP165C4 0.001
4989 Cytochrome c551 peroxidase ccp 0.001
5222 Cytochrome c551 peroxidase ccpA 0.001
4937 Cytochrome oxidase subunit II rcoxA 0.001
4926 Heme-based aerotactic transducer hemAT hemAT 0.001
4935 Cytochrome c-554 cycA1 0.001
4999 Cytochrome P450 165B3 CYP165B3 0.001
4960 Putative cytochrome P450-family protein SCO7417 0.001
4931 Cytochrome P450 167A1 CYP167A1 0.001
4972 P450cin cinA 0.001
4993 Hydroxylamine oxidoreductase hao1 0.001
4922 Cytochrome c, putative SO_4144 0.001
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.001
4952 Catalase/peroxidase katA 0.001
4903 Methyl-accepting chemotaxis protein Tar4 0.001
3093 Catalase HPII katE 0.001
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.001
563 Thyroid peroxidase TPO 0.001
6138 Multidrug resistance protein 3 ABCB4 0.001
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.001
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.001
4122 Histone deacetylase 2 HDAC2 0.001
16 Adenosine A1 receptor ADORA1 0.001
1178 Adenosine A2a receptor ADORA2A 0.001
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.001
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.001
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0009
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0009
1341 Histamine H3 receptor HRH3 0.0009
2808 Chloramphenicol acetyltransferase 3 cat3 0.0009
537 ATP synthase delta chain, mitochondrial ATP5D 0.0009
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0009
84 Nuclear receptor 0B1 NR0B1 0.0009
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0009
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0009
1184 Interferon beta IFNB1 0.0008
2417 Chloramphenicol acetyltransferase cat 0.0008
3278 Chloramphenicol acetyltransferase cat 0.0008
2810 Dr hemagglutinin structural subunit draA 0.0008
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0008
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0008
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0008
26 Vascular endothelial growth factor receptor 3 FLT4 0.0008
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0008
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0008
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0008
581 Cytochrome P450 2R1 CYP2R1 0.0008
32 Vascular endothelial growth factor receptor 1 FLT1 0.0008
4920 Peroxidase/catalase katG 0.0008
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0008
3830 Calreticulin CALR 0.0008
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0008
2119 Cytochrome b5 CYB5A 0.0008
4037 Hypothetical protein GPX1 0.0008
4297 Hypothetical protein SP_1951 0.0008
4521 Hypothetical protein BC_2969 0.0008
4540 Hypothetical protein TM_1070 0.0008
4555 Hypothetical protein MT1739 0.0008
4569 Hypothetical protein mshD 0.0008
4578 Hypothetical protein PA3270 0.0008
4747 Hypothetical protein PA3967 0.0008
5177 Hypothetical protein TM_0096 0.0008
5194 Hypothetical protein PA1204 0.0008
5240 Hypothetical protein Rv2991 0.0008
5370 Hypothetical protein TM_1158 0.0008
5710 Hypothetical protein Tb927.5.1360 0.0008
4773 Deoxycytidine kinase DCK 0.0008
161 Tubulin beta chain TUBB 0.0008
312 Tubulin beta chain TUB2 0.0008
4990 PpcA ppcA 0.0007
4289 Cytochrome P450 TT_P0059 0.0007
6262 Cytochrome P450 staP 0.0007
4992 Cytochrome c peroxidase Not Available 0.0007
3570 Cytochrome P450 152A1 cypC 0.0007
4988 Sulfite oxidase, mitochondrial SUOX 0.0007
2915 Sensor protein fixL fixL 0.0007
4944 Sensor protein fixL fixL 0.0007
3375 Acidic cytochrome c3 Not Available 0.0007
4385 Cytochrome c' Not Available 0.0007
4967 Cytochrome c' cycA 0.0007
5038 Cytochrome c' Not Available 0.0007
5223 Cytochrome c' cycP 0.0007
4813 Heme oxygenase hmuO 0.0007
5769 Heme oxygenase Not Available 0.0007
1992 Vitamin D-binding protein GC 0.0007
319 Opioid receptor, sigma 1 OPRS1 0.0007
2230 Catalase CAT 0.0007
3249 Catalase katA 0.0007
3625 Catalase katA 0.0007
4539 Catalase katA 0.0007
4941 Catalase katB 0.0007
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0007
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0007
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0007
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0007
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0007
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0007
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0007
6034 Hydroxyindole O-methyltransferase ASMT 0.0007
6035 Nuclear receptor ROR-beta RORB 0.0007
6036 Eosinophil peroxidase EPX 0.0007
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0007
976 Platelet glycoprotein IX GP9 0.0007
1630 Integrin beta-2 ITGB2 0.0007
4666 Fucose-binding lectin PA-IIL lecB 0.0007
2372 Bifunctional tail protein 9 0.0007
4226 Uridine phosphorylase 2 UPP2 0.0007
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0007
4217 Telomerase reverse transcriptase TERT 0.0007
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0007
3670 Soluble cytochrome b562 precursor cybC 0.0007
3411 Cytochrome P450 121 cyp121 0.0007
2617 Nitric oxide synthase oxygenase nos 0.0007
2701 Nitric oxide synthase oxygenase nos 0.0007
3291 Cytochrome c-552 cycA 0.0007
4927 Cytochrome c-552 nrfA 0.0007
4938 Cytochrome c-552 cycA 0.0007
4953 Cytochrome c-552 nrfA 0.0007
5217 Cytochrome c-552 cycM 0.0007
814 Ryanodine receptor 1 RYR1 0.0007
3102 Flavohemoprotein hmp 0.0006
4969 Flavohemoprotein hmp 0.0006
4878 Glycoprotein hormones alpha chain CGA 0.0006
1052 Cytotoxic T-lymphocyte protein 4 CTLA4 0.0006
1072 Granzyme B GZMB 0.0006
4871 Endo-beta-N-acetylglucosaminidase F3 endOF3 0.0006
4880 Membrane cofactor protein CD46 0.0006
4889 Ig epsilon chain C region IGHE 0.0006
4877 Beta-mannanase man 0.0006
1563 Platelet glycoprotein Ib alpha chain GP1BA 0.0006
4850 Beta-2-glycoprotein 1 APOH 0.0006
4856 CD209 antigen CD209 0.0006
4189 Alpha-galactosidase A GLA 0.0006
4869 Major capsid protein A430L 0.0006
757 Fusion glycoprotein F0 F 0.0006
4875 Fusion glycoprotein F0 F 0.0006
4852 Reticulon-4 receptor RTN4R 0.0006
4845 ADAM 33 ADAM33 0.0006
1354 Beta-glucuronidase GUSB 0.0006
442 Envelope glycoprotein gp41 0.0006
4859 Envelope glycoprotein env 0.0006
4882 Dipeptidyl aminopeptidase-like protein 6 DPP6 0.0006
4721 Beta-1,4-mannanase manA 0.0006
3352 Structural polyprotein Not Available 0.0006
3628 Structural polyprotein Not Available 0.0006
4892 Structural polyprotein Not Available 0.0006
239 Coagulation factor X F10 0.0006
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0006
76 Nitric-oxide synthase, brain NOS1 0.0006
251 Alcohol dehydrogenase 1A ADH1A 0.0006
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0006
174 Sigma 1-type opioid receptor SIGMAR1 0.0006
765 Indoleamine 2,3-dioxygenase IDO1 0.0006
4225 Uridine phosphorylase 1 UPP1 0.0006
705 Glutamate receptor 1 GRIA1 0.0006
6048 Troponin C, skeletal muscle TNNC2 0.0006
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0006
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0006
605 Fumarate reductase flavoprotein subunit frdA 0.0006
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0006
3673 Fumarate reductase flavoprotein subunit fccA 0.0006
4912 Fumarate reductase flavoprotein subunit ifcA 0.0006
6549 Fumarate reductase flavoprotein subunit frdA 0.0006
2972 6-deoxyerythronolide B hydroxylase eryF 0.0006
719 Retinoic acid receptor responder protein 1 RARRES1 0.0006
378 Alpha-2C adrenergic receptor ADRA2C 0.0006
770 Retinoic acid-induced protein 3 GPRC5A 0.0006
820 Glycine receptor subunit alpha-2 GLRA2 0.0006
268 Adenosine A2b receptor ADORA2B 0.0006
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0006
413 Amidophosphoribosyltransferase PPAT 0.0006
2515 Amidophosphoribosyltransferase purF 0.0006
3714 Amidophosphoribosyltransferase purF 0.0006
163 D(1B) dopamine receptor DRD5 0.0006
6044 Serum paraoxonase/lactonase 3 PON3 0.0006
4608 Putative cytochrome P450 SCO1207 0.0006
4963 Putative cytochrome P450 SCO2884 0.0006
6254 Putative cytochrome P450 SCO6998 0.0006
4193 Atrial natriuretic peptide clearance receptor NPR3 0.0006
793 T-cell surface antigen CD2 CD2 0.0006
4861 Interleukin-6 receptor alpha chain IL6R 0.0006
119 Carcinoembryonic antigen-related cell adhesion molecule 1 CEACAM1 0.0006
3837 Cytokine receptor common beta chain CSF2RB 0.0006
5221 Cytochrome c3, 13 kDa Not Available 0.0006
3152 Cytochrome c'' cycA 0.0006
5220 Split-Soret cytochrome c Ddes_2150 0.0006
3700 Cytochrome c-552 precursor nrfA 0.0006
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0005
444 Alcohol dehydrogenase 1B ADH1B 0.0005
856 Vitamin D3 receptor VDR 0.0005
2430 Chondroitinase B cslB 0.0005
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0005
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0005
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0005
572 Integrin alpha-L ITGAL 0.0005
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0005
358 Cystathionine beta-synthase CBS 0.0005
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0005
5924 Microtubule-associated protein 4 MAP4 0.0005
5923 Microtubule-associated protein tau MAPT 0.0005
5798 Mitogen-activated protein kinase 11 MAPK11 0.0005
2320 Thymidine kinase, cytosolic TK1 0.0005
267 Plasminogen activator inhibitor 1 SERPINE1 0.0005
569 Retinal dehydrogenase 2 ALDH1A2 0.0005
693 Hemoglobin subunit beta HBB 0.0005
1379 Interleukin-12 subunit beta IL12B 0.0005
4890 Hemagglutinin HA 0.0005
6566 Hemagglutinin Not Available 0.0005
1852 Microtubule-associated protein 2 MAP2 0.0005
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0005
611 Retinal dehydrogenase 1 ALDH1A1 0.0005
3127 Nitrite reductase nirS 0.0005
3284 Nitrite reductase nirS 0.0005
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0005
1268 Neuropeptide S receptor NPSR1 0.0005
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0005
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0005
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0005
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0005
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0005
4857 Zinc-alpha-2-glycoprotein AZGP1 0.0005
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0005
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0005
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0005
6268 Hydroxyacid oxidase 1 HAO1 0.0005
6858 Inactive carboxylesterase 4 CES1P1 0.0005
517 Alcohol dehydrogenase 1C ADH1C 0.0005
952 Dipeptidyl peptidase 4 DPP4 0.0005
6218 Pannexin-1 PANX1 0.0005
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0005
810 Heme oxygenase 1 HMOX1 0.0005
3391 Heme oxygenase 1 pbsA1 0.0005
6120 Cation-independent mannose-6-phosphate receptor IGF2R 0.0005
6221 Steroid hormone receptor ERR1 ESRRA 0.0005
5934 Cytochrome P450 26A1 CYP26A1 0.0005
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0005
18 High affinity immunoglobulin epsilon receptor subunit alpha FCER1A 0.0005
751 Potassium channel subfamily K member 6 KCNK6 0.0004
554 Low-density lipoprotein receptor LDLR 0.0004
852 Heparin cofactor 2 SERPIND1 0.0004
1256 5-hydroxytryptamine 6 receptor HTR6 0.0004
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0004
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0004
3917 Methylenetetrahydrofolate reductase MTHFR 0.0004
6073 Potassium channel subfamily K member 9 KCNK9 0.0004
6072 Potassium channel subfamily K member 3 KCNK3 0.0004
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0004
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0004
3405 Quinohaemoprotein ethanol dehydrogenase type-1 qheDH 0.0004
1859 Prostatic acid phosphatase ACPP 0.0004
3937 Fatty-acid amide hydrolase FAAH 0.0004
595 Fibrinogen alpha chain FGA 0.0004
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0004
2298 Cytochrome P450-cam camC 0.0004
3140 Hemagglutinin-neuraminidase HN 0.0004
3609 Hemagglutinin-neuraminidase HN 0.0004
172 Potassium channel subfamily K member 1 KCNK1 0.0004
3444 Cyanovirin-N Not Available 0.0004
3258 Mannosyl-oligosaccharide alpha-1,2-mannosidase MSDC 0.0004
936 Ephrin type-A receptor 2 EPHA2 0.0004
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0004
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0004
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0004
165 FL cytokine receptor FLT3 0.0004
5787 Angiopoietin-1 receptor TEK 0.0004
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0004
3957 Adenosine deaminase ADA 0.0004
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0004
4509 Acetoin(diacetyl) reductase budC 0.0004
162 Retinoic acid receptor gamma-1 RARG 0.0004
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0004
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0004
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0004
958 Insulin-like growth factor 1 receptor IGF1R 0.0004
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0004
469 Annexin A1 ANXA1 0.0004
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0004
3689 Endoglucanase A celA 0.0004
3009 Beta-glucanase Not Available 0.0004
5411 Slt-IIvB stxB2e 0.0004
5565 Inorganic polyphosphate/ATP-glucomannokinase ppgmk 0.0004
5563 Galectin-2 LGALS2 0.0004
1875 Pulmonary surfactant-associated protein D SFTPD 0.0004
5569 Endo-1,4-beta glucanase EngF engF 0.0004
5046 Ecotin eco 0.0004
3793 Aspartate ammonia-lyase aspA 0.0004
5554 D-galactose-binding periplasmic protein mglB 0.0004
3741 D-galactose-binding periplasmic protein precursor mglB 0.0004
5568 Endoglucanase C307 celC307 0.0004
5553 Endoglucanase E1 Acel_0614 0.0004
5562 Hexokinase Not Available 0.0004
3744 Endoglucanase SS precursor celS 0.0004
5570 Endoglucanase E-4 celD 0.0004
5559 Neopullulanase nplT 0.0004
4670 Cellulase B celB 0.0004
4668 Laminarinase TM_0024 0.0004
4667 BH0236 protein BH0236 0.0004
4671 Endoglucanase C cenC 0.0004
64 Neuraminidase NA 0.0004
641 Neuraminidase NA 0.0004
2676 Neuraminidase NA 0.0004
3026 Neuraminidase NA 0.0004
3519 Neuraminidase NA 0.0004
6007 Neuraminidase NA 0.0004
284 DNA-directed RNA polymerase beta chain rpoB 0.0004
5773 DNA-directed RNA polymerase beta chain rpoB 0.0004
2577 Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase MAN1B1 0.0004
1243 Cathepsin D CTSD 0.0003
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0003
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0003
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0003
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0003
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0003
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0003
309 Antithrombin-III SERPINC1 0.0003
1782 Neutrophil gelatinase-associated lipocalin LCN2 0.0003
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0003
5176 YtnJ moxC 0.0003
5416 Coat protein VP1 Not Available 0.0003
2705 Dimethyl sulfoxide reductase dmsA 0.0003
5247 Endo-1,4-beta-xylanase Not Available 0.0003
5248 Endo-1,4-beta-xylanase xlnA 0.0003
5250 Endo-1,4-beta-xylanase xyl 0.0003
4669 Endo-1,4-beta-xylanase A xynA 0.0003
4715 Endo-1,4-beta-xylanase A xlnA 0.0003
5560 Endo-1,4-beta-xylanase A xynA 0.0003
1503 Galectin-7 LGALS7 0.0003
5498 Maltoporin lamB 0.0003
5561 Maltoporin lamB 0.0003
5056 Maltooligosyltrehalose trehalohydrolase, putative treZ 0.0003
3525 ADP-ribose pyrophosphatase, mitochondrial NUDT9 0.0003
4622 Amylase Not Available 0.0003
2728 Glucan 1,4-alpha-maltotetraohydrolase amyP 0.0003
6307 Ig gamma-2 chain C region IGHG2 0.0003
2826 Glucose--fructose oxidoreductase gfo 0.0003
1881 Hexokinase-1 HK1 0.0003
2581 Chondroitinase AC cslA 0.0003
6847 Lactase-phlorizin hydrolase LCT 0.0003
2324 Botulinum neurotoxin type B botB 0.0003
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0003
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0003
3153 Quinoprotein glucose dehydrogenase-B gdhB 0.0003
3747 Cellulase B precursor celB 0.0003
3547 Enterotoxin type B entB 0.0003
2856 Glucosamine-6-phosphate isomerase GNPDA1 0.0003
2564 Glucan 1,4-alpha-maltohexaosidase Not Available 0.0003
4819 Hydrolase Not Available 0.0003
5249 Hydrolase Not Available 0.0003
5436 Hydrolase Not Available 0.0003
2531 Alpha-amylase amyE 0.0003
2948 Alpha-amylase amy 0.0003
3169 Alpha-amylase Not Available 0.0003
2541 Neopullulanase 1 tvaI 0.0003
4811 Amylosucrase ams 0.0003
3091 Maltodextrin phosphorylase malP 0.0003
2606 Neopullulanase 2 tvaII 0.0003
4692 A/G-specific adenine glycosylase mutY 0.0003
3225 Shiga toxin B-chain stxB 0.0003
3365 Beta-amylase spoII 0.0003
4830 Aldose 1-epimerase galM 0.0003
6614 Lactase-like protein LCTL 0.0003
1675 Glucokinase GCK 0.0003
4662 Glucokinase glk 0.0003
3030 Salivary alpha-amylase AMY1A 0.0003
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0003
2293 Cyclomaltodextrin glucanotransferase Not Available 0.0003
2508 Cyclomaltodextrin glucanotransferase cgt 0.0003
2523 Cyclomaltodextrin glucanotransferase cgt 0.0003
3207 Cyclomaltodextrin glucanotransferase amyA 0.0003
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0003
4272 POSSIBLE CELLULASE CELA1 celA1 0.0003
2570 Tetanus toxin tetX 0.0002
2448 Exoglucanase/xylanase [Includes: Exoglucanase cex 0.0002
3668 Maltose-binding periplasmic protein precursor malE 0.0002
2802 Endoglucanase G celCCG 0.0002
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0002
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0002
2440 Endoglucanase F celCCF 0.0002
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0002
2245 Xylose isomerase xylA 0.0002
2253 Xylose isomerase xylA 0.0002
2260 Xylose isomerase xylA 0.0002
2431 Xylose isomerase xylA 0.0002
2252 Endoglucanase 5A cel5A 0.0002
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0002
10 Glycogen phosphorylase, liver form PYGL 0.0002
2723 Cholera enterotoxin subunit B ctxB 0.0002
4513 Pancreatic alpha-amylase AMY2A 0.0002
2427 Ferrichrome-iron receptor fhuA 0.0002
1152 Glycogen phosphorylase, muscle form PYGM 0.0002
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