DT-Web

DB00784 - Mefenamic acid


Identification
Name Mefenamic acid
Accession Number DB00784 (APRD00730)
Type small molecule
Description A non-steroidal anti-inflammatory agent with analgesic, anti-inflammatory, and antipyretic properties. It is an inhibitor of cyclooxygenase. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 241.2851
Groups approved
Monoisotopic Weight 241.110278729
Pharmacology
Indication For the treatment of rheumatoid arthritis, osteoarthritis, dysmenorrhea, and mild to moderate pain, inflammation, and fever.
Mechanism of action Mefenamic acid binds the prostaglandin synthetase receptors COX-1 and COX-2, inhibiting the action of prostaglandin synthetase. As these receptors have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity, the symptoms of pain are temporarily reduced.
Absorption Mefenamic acid is rapidly absorbed after oral administration.
Protein binding 90%
Biotransformation Mefenamic acid undergoes metabolism by CYP2C9 to 3-hydroxymethyl mefenamic acid, and further oxidation to a 3-carboxymefenamic acid may occur. The activity of these metabolites has not been studied. Mefenamic acid is also glucuronidated directly.
Route of elimination The fecal route of elimination accounts for up to 20% of the dose, mainly in the form of unconjugated 3-carboxymefenamic acid.3 The elimination half-life of mefenamic acid is approximately two hours. Mefenamic acid, its metabolites and conjugates are primarily excreted by the kidneys. Both renal and hepatic excretion are significant pathways of elimination.
Toxicity Oral, rat LD50: 740 mg/kg. Symptoms of overdose may include severe stomach pain, coffee ground-like vomit, dark stool, ringing in the ears, change in amount of urine, unusually fast or slow heartbeat, muscle weakness, slow or shallow breathing, confusion, severe headache or loss of consciousness.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Acenocoumarol The NSAID, mefanamic acid, may increase the anticoagulant effect of acenocoumarol.
Alendronate Increased risk of gastric toxicity
Anisindione The NSAID, mefanamic acid, may increase the anticoagulant effect of anisindione.
Azilsartan medoxomil Increases toxicity of each. May deteriorate renal function, particularly in volume depleted or elderly patients. Decreases effects of azilsartan by antagonism.
Colesevelam Bile acid sequestrants may decrease the absorption of Nonsteroidal Anti-Inflammatory Agents. Monitor for decreased serum concentrations/therapeutic effects of nonsteroidal anti-inflammatory agents (NSAID) if coadministered with bile acid sequestrants. Separating the administration of doses by 2 or more hours may reduce (but not eliminate) the risk of interaction. The manufacturer of colesevelam recommends that drugs should be administered at least 1 hour before or 4 hours after colesevelam.
Cyclosporine Monitor for nephrotoxicity
Dicumarol The NSAID, mefanamic acid, may increase the anticoagulant effect of dicumarol.
Eltrombopag Increases levels of Mefenamic acid via metabolism decrease. UDP-glucuronosyltransferase inhibition with unclear significance.
Lithium The NSAID, mefenamic acid, may decrease the renal excretion of lithium. Increased risk of lithium toxicity.
Methotrexate The NSAID, mefenamic acid, may decrease the renal excretion of methotrexate. Increased risk of methotrexate toxicity.
Tamoxifen Mefenamic acid may reduce clearance rate of Tamoxifen. Monitor for changes in therapeutic/adverse effects of Tamoxifen if Mefenamic acid is initiated, discontinued or dose changed.
Tolbutamide Mefanamic acid, a strong CYP2C9 inhibitor, may decrease the metabolism and clearance of Tolbutamide, a CYP2C9 substrate. Consider alternate therapy or monitor for changes in Tolbutamide therapeutic and adverse effects if Mefanamic acid is initiated, discontinued or dose changed.
Torasemide Mefanamic acid, a strong CYP2C9 inhibitor, may increase the serum concentration of Torasemide, a CYP2C9 substrate, by decreasing Torasemide metabolism and clearance. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of Torasemide if Mefanamic acid is initiated, discontinued or dose changed.
Trandolapril The NSAID, Mefenamic acid, may reduce the antihypertensive effect of Trandolapril. Consider alternate therapy or monitor for changes in Trandolapril efficacy if Mefenamic acid is initiated, discontinued or dose changed.
Treprostinil The prostacyclin analogue, Treprostinil, may increase the risk of bleeding when combined with the NSAID, Mefenamic acid. Monitor for increased bleeding during concomitant thearpy.
Trimethoprim The strong CYP2C9 inhibitor, Mefenamic acid, may decrease the metabolism and clearance of Trimethoprim, a CYP2C9 substrate. Consider alternate therapy or monitor for changes in therapeutic and adverse effects of Trimethoprim if Mefenamic acid is initiated, discontinued or dose changed.
Voriconazole Mefanamic acid, a strong CYP2C9 inhibitor, may increase the serum concentration of voriconazole by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of voriconazole if mefanamic acid is initiated, discontinued or dose changed.
Warfarin Mefenamic acid, a strong CYP2C9 inhibitor, may decrease the metabolism of warfarin. The antiplatelet effect of mefenamic acid may also increase the bleed risk associated with warfarin. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of warfarin if mefenamic acid is initiated, discontinued or dose changed.
Food Interactions
  • Take with food.
  • Avoid alcohol.

Targets


Prostaglandin G/H synthase 2
Name Prostaglandin G/H synthase 2
Gene Name PTGS2
Pharmacological action yes
Actions inhibitor
References
  • Gierse JK, Hauser SD, Creely DP, Koboldt C, Rangwala SH, Isakson PC, Seibert K: Expression and selective inhibition of the constitutive and inducible forms of human cyclo-oxygenase. Biochem J. 1995 Jan 15;305 ( Pt 2):479-84. - Pubmed
  • Bhat AS, Tandan SK, Kumar D, Krishna V, Prakash VR: Interaction between inhibitors of inducible nitric oxide synthase and cyclooxygenase in adjuvant-induced arthritis in female albino rats: an isobolographic study. Eur J Pharmacol. 2007 Feb 5;556(1-3):190-9. Epub 2006 Oct 27. - Pubmed
  • Bhat AS, Tandan SK, Kumar D, Krishna V, Prakash VR: Interaction between inhibitors of inducible nitric oxide synthase and cyclooxygenase in Brewer's yeast induced pyrexia in mice: an isobolographic study. Eur J Pharmacol. 2005 Mar 28;511(2-3):137-42. - Pubmed
  • Cryer B, Feldman M: Cyclooxygenase-1 and cyclooxygenase-2 selectivity of widely used nonsteroidal anti-inflammatory drugs. Am J Med. 1998 May;104(5):413-21. - Pubmed
  • Walton LJ, Franklin IJ, Bayston T, Brown LC, Greenhalgh RM, Taylor GW, Powell JT: Inhibition of prostaglandin E2 synthesis in abdominal aortic aneurysms: implications for smooth muscle cell viability, inflammatory processes, and the expansion of abdominal aortic aneurysms. Circulation. 1999 Jul 6;100(1):48-54. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 0.5278
Prostaglandin G/H synthase 1
Name Prostaglandin G/H synthase 1
Gene Name PTGS1
Pharmacological action unknown
Actions inhibitor
References
  • Sinniah R, Lye WC: Acute renal failure from hemoglobinuric and interstitial nephritis secondary to iodine and mefenamic acid. Clin Nephrol. 2001 Mar;55(3):254-8. - Pubmed
  • Joo Y, Kim HS, Woo RS, Park CH, Shin KY, Lee JP, Chang KA, Kim S, Suh YH: Mefenamic acid shows neuroprotective effects and improves cognitive impairment in in vitro and in vivo Alzheimer's disease models. Mol Pharmacol. 2006 Jan;69(1):76-84. Epub 2005 Oct 13. - Pubmed
  • Cryer B, Feldman M: Cyclooxygenase-1 and cyclooxygenase-2 selectivity of widely used nonsteroidal anti-inflammatory drugs. Am J Med. 1998 May;104(5):413-21. - Pubmed
  • Gierse JK, Hauser SD, Creely DP, Koboldt C, Rangwala SH, Isakson PC, Seibert K: Expression and selective inhibition of the constitutive and inducible forms of human cyclo-oxygenase. Biochem J. 1995 Jan 15;305 ( Pt 2):479-84. - Pubmed
  • Laudanno OM, Cesolari JA, Esnarriaga J, Flaherty P, Vada J, Guastalli G, San Miguel P, Bedini OA: [In vivo selectivity of nonsteroidal anti-inflammatory drugs on COX-1-COX-2 and gastrointestinal ulcers, in rats] Acta Gastroenterol Latinoam. 1998;28(3):249-55. - Pubmed
DTHybrid score 0.5989

Enzymes


Cytochrome P450 2C9
Name Cytochrome P450 2C9
Gene Name CYP2C9
Actions substrate,inhibitor
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3666
Cytochrome P450 2C8
Name Cytochrome P450 2C8
Gene Name CYP2C8
Actions substrate,inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.2478

Predictions


Id Partner name Gene Name Score
4512 Cytochrome P450 3A4 CYP3A4 0.1847
6016 Cytochrome P450 2C19 CYP2C19 0.1563
4200 Cytochrome P450 1A2 CYP1A2 0.1169
4119 Cytochrome P450 2D6 CYP2D6 0.1107
587 Serum albumin ALB 0.0879
1588 Multidrug resistance protein 1 ABCB1 0.0862
1729 Solute carrier family 22 member 6 SLC22A6 0.0782
6030 Cytochrome P450 2B6 CYP2B6 0.0703
4118 Cytochrome P450 3A5 CYP3A5 0.07
6013 Cytochrome P450 2E1 CYP2E1 0.069
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0497
6107 Cytochrome P450 3A7 CYP3A7 0.0491
275 Arachidonate 5-lipoxygenase ALOX5 0.0489
5718 Cytochrome P450 2A6 CYP2A6 0.0469
6024 Cytochrome P450 1A1 CYP1A1 0.0446
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.039
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0368
6106 Cytochrome P450 2C18 CYP2C18 0.0368
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0361
6142 Solute carrier family 22 member 8 SLC22A8 0.0345
1757 Myeloperoxidase MPO 0.0343
2164 Multidrug resistance-associated protein 4 ABCC4 0.0342
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0334
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0299
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0293
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0292
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0275
1024 Solute carrier family 22 member 11 SLC22A11 0.0267
6143 Solute carrier family 22 member 7 SLC22A7 0.0211
862 Multidrug resistance-associated protein 1 ABCC1 0.0207
1181 Alpha-1-acid glycoprotein 1 ORM1 0.02
3312 Fatty acid-binding protein, brain FABP7 0.0199
373 Transthyretin TTR 0.0186
1159 Interleukin-6 IL6 0.0185
1898 Cytochrome P450 1B1 CYP1B1 0.0174
3811 Cytochrome P450 19A1 CYP19A1 0.0164
146 Androgen receptor AR 0.0161
3923 Cholinesterase BCHE 0.0159
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0159
492 Histamine H1 receptor HRH1 0.0158
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0154
891 Dihydropteroate synthase folP 0.0152
5359 Dihydropteroate synthase folP 0.0152
7175 Dihydropteroate synthase sulI 0.0152
70 Type-1 angiotensin II receptor AGTR1 0.0151
777 Tumor necrosis factor TNF 0.015
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0144
6102 Arylamine N-acetyltransferase 2 NAT2 0.0141
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0136
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0136
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0135
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0135
672 Prostaglandin F2-alpha receptor PTGFR 0.0135
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0133
703 NADPH azoreductase azr 0.0132
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0131
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0131
136 Estrogen receptor ESR1 0.013
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0127
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0126
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0125
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0124
850 Vasopressin V1b receptor AVPR1B 0.0122
738 Monocarboxylate transporter 1 SLC16A1 0.0121
6220 Aryl hydrocarbon receptor AHR 0.0119
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0119
1648 Elastin ELN 0.0119
824 Sodium-dependent serotonin transporter SLC6A4 0.0118
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0117
1507 Cytochrome c CYCS 0.0117
853 Farnesyl pyrophosphate synthetase FDPS 0.0113
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0113
776 Bile salt export pump ABCB11 0.0111
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.011
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0109
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0109
185 Vasopressin V1a receptor AVPR1A 0.0107
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0107
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0107
6012 Tryptophan 2,3-dioxygenase TDO2 0.0106
811 Translocator protein TSPO 0.0106
322 Vasopressin V2 receptor AVPR2 0.0105
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0103
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0102
130 Prostacyclin synthase PTGIS 0.0102
6085 Fatty acid-binding protein, intestinal FABP2 0.0101
696 Kappa-type opioid receptor OPRK1 0.0101
6145 Solute carrier family 22 member 1 SLC22A1 0.0099
1439 Lactotransferrin LTF 0.0098
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0098
2183 Fatty acid-binding protein, adipocyte FABP4 0.0098
122 P2Y purinoceptor 12 P2RY12 0.0098
6144 Solute carrier family 22 member 2 SLC22A2 0.0098
502 5-hydroxytryptamine 2A receptor HTR2A 0.0098
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0097
467 Delta-type opioid receptor OPRD1 0.0097
6141 Sodium/bile acid cotransporter SLC10A1 0.0093
847 Mu-type opioid receptor OPRM1 0.0093
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0092
6137 Multidrug resistance-associated protein 6 ABCC6 0.009
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.009
4132 Chloride channel protein ClC-Ka CLCNKA 0.009
558 Solute carrier family 12 member 1 SLC12A1 0.0089
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0087
4116 Dihydropteroate synthetase Not Available 0.0087
782 ADP/ATP translocase 2 SLC25A5 0.0086
688 ADP/ATP translocase 3 SLC25A6 0.0086
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0086
871 Glucocorticoid receptor NR3C1 0.0085
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0085
831 D(2) dopamine receptor DRD2 0.0084
723 Cytosolic phospholipase A2 PLA2G4A 0.0083
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0082
3947 Xanthine dehydrogenase/oxidase XDH 0.0082
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0081
6033 High affinity interleukin-8 receptor A CXCR1 0.0081
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.008
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.008
61 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0079
2644 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0079
2710 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0079
468 Cytochrome P450 4A11 CYP4A11 0.0079
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0079
260 Cytochrome P450 51 ERG11 0.0079
761 Cytochrome P450 51 ERG11 0.0079
3163 Cytochrome P450 51 cyp51 0.0079
6043 Putative G-protein coupled receptor 44 GPR44 0.0078
118 Organic cation/carnitine transporter 2 SLC22A5 0.0077
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0077
737 Mineralocorticoid receptor NR3C2 0.0076
341 5-hydroxytryptamine 3 receptor HTR3A 0.0076
731 HIV-1 protease HIV-1 protease 0.0076
6031 Cytochrome P450 3A43 CYP3A43 0.0076
4221 Vascular endothelial growth factor VEGF 0.0075
5816 Cadherin-5 CDH5 0.0075
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0074
614 Progesterone receptor PGR 0.0074
3941 Amine oxidase [flavin-containing] A MAOA 0.0072
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0072
823 Fibroblast growth factor receptor 2 FGFR2 0.0072
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0071
6182 Cytochrome P450 2J2 CYP2J2 0.007
6136 Multidrug resistance-associated protein 5 ABCC5 0.0069
1275 Estrogen sulfotransferase SULT1E1 0.0068
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0067
427 Substance-P receptor TACR1 0.0067
489 Monocarboxylate transporter 2 SLC16A7 0.0066
365 Dihydrofolate reductase DHFR 0.0066
2381 Dihydrofolate reductase DFR1 0.0066
2833 Dihydrofolate reductase Not Available 0.0066
2931 Dihydrofolate reductase folA 0.0066
3544 Dihydrofolate reductase folA 0.0066
3682 Dihydrofolate reductase folA 0.0066
6642 Dihydrofolate reductase folA 0.0066
6756 Dihydrofolate reductase dfrA 0.0066
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0066
661 ADP/ATP translocase 1 SLC25A4 0.0064
459 Retinoic acid receptor RXR-alpha RXRA 0.0064
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0064
3808 Dihydropteroate synthase 2 folP2 0.0064
3601 Dihydropteroate synthase 1 folP1 0.0064
3807 Dihydropteroate synthase 1 folP1 0.0064
133 Dihydropterate synthase sulI 0.0063
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0063
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0061
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0061
3823 Cytokine receptor common gamma chain IL2RG 0.0061
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0061
465 Calmodulin CALM1 0.006
504 Mast/stem cell growth factor receptor KIT 0.006
1656 CYP2B protein CYP2B 0.006
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.006
134 Tryptophan 5-hydroxylase 1 TPH1 0.006
1541 Metalloproteinase mmp20 0.006
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0059
590 5-hydroxytryptamine 2C receptor HTR2C 0.0059
6103 Arylamine N-acetyltransferase 1 NAT1 0.0058
6149 Solute carrier family 22 member 10 SLC22A10 0.0058
4604 Liver carboxylesterase 1 CES1 0.0057
3939 Amine oxidase [flavin-containing] B MAOB 0.0057
713 Sodium-dependent dopamine transporter SLC6A3 0.0057
6500 Phospholipase A2 PLA2G1B 0.0057
556 Alpha-1A adrenergic receptor ADRA1A 0.0057
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0056
759 Free fatty acid receptor 1 FFAR1 0.0056
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0056
1818 Long-chain-fatty-acid--CoA ligase 3 ACSL3 0.0056
6148 Multidrug resistance-associated protein 7 ABCC10 0.0056
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0055
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0055
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0055
766 Beta-2 adrenergic receptor ADRB2 0.0055
828 Phenylalanine-4-hydroxylase PAH 0.0054
3109 Phenylalanine-4-hydroxylase phhA 0.0054
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0054
676 Tyrosine 3-monooxygenase TH 0.0054
3810 Catechol O-methyltransferase COMT 0.0053
724 Interleukin-2 receptor alpha chain IL2RA 0.0053
717 Interleukin-2 receptor subunit beta IL2RB 0.0053
2853 14 kDa fatty acid-binding protein Not Available 0.0053
1050 Bile salt sulfotransferase SULT2A1 0.0052
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0052
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0051
2981 Phospholipase A2, membrane associated PLA2G2A 0.0051
6147 Solute carrier family 22 member 3 SLC22A3 0.0051
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0051
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0051
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.005
380 Cytochrome P450 17A1 CYP17A1 0.005
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.005
1714 Mitogen-activated protein kinase 3 MAPK3 0.005
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.005
1629 Transcription factor AP-1 JUN 0.0049
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0049
817 DNA topoisomerase 2-alpha TOP2A 0.0049
7 Nitric oxide synthase, inducible NOS2 0.0049
1053 BC269730_2 FADS1 0.0049
1395 Sodium/calcium exchanger 1 SLC8A1 0.0049
1192 Sulfotransferase 1A1 SULT1A1 0.0049
24 Thymidylate synthase TMP1 0.0048
359 Thymidylate synthase TYMS 0.0048
2626 Thymidylate synthase thyA 0.0048
2729 Thymidylate synthase thyA 0.0048
5352 Thymidylate synthase THYA 0.0048
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0048
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0047
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0046
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0046
88 Retinoic acid receptor RXR-beta RXRB 0.0046
1558 Transient receptor potential cation channel subfamily V member 1 TRPV1 0.0046
33 Cystine/glutamate transporter SLC7A11 0.0045
1650 Heme carrier protein 1 SLC46A1 0.0045
527 Prostacyclin receptor PTGIR 0.0045
844 Epidermal growth factor receptor EGFR 0.0045
869 Estrogen receptor beta ESR2 0.0045
6014 Cytochrome P450 2A13 CYP2A13 0.0045
94 5-hydroxytryptamine 4 receptor HTR4 0.0045
6146 High affinity copper uptake protein 1 SLC31A1 0.0045
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0045
634 Squalene monooxygenase SQLE 0.0044
7196 Squalene monooxygenase ERG1 0.0044
908 Glutathione S-transferase theta-1 GSTT1 0.0044
632 Alpha-1B adrenergic receptor ADRA1B 0.0044
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0044
291 Nitric-oxide synthase, endothelial NOS3 0.0044
49 Endothelin B receptor EDNRB 0.0044
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0043
23 D(1A) dopamine receptor DRD1 0.0043
320 5-hydroxytryptamine 1A receptor HTR1A 0.0042
2021 Thrombomodulin THBD 0.0042
2236 Casein kinase II subunit alpha CSNK2A1 0.0042
407 Vascular endothelial growth factor receptor 2 KDR 0.0042
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0041
29 Tubulin beta-1 chain TUBB1 0.0041
318 Alpha-2A adrenergic receptor ADRA2A 0.0041
578 Endothelin-1 receptor EDNRA 0.0041
295 Carbonic anhydrase 1 CA1 0.0041
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0041
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0041
4203 Histamine N-methyltransferase HNMT 0.0041
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0041
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.004
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.004
273 Apoptosis regulator Bcl-2 BCL2 0.004
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.004
232 Corticosteroid-binding globulin SERPINA6 0.0039
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0039
228 Beta platelet-derived growth factor receptor PDGFRB 0.0037
921 Glutamate receptor 2 GRIA2 0.0037
1789 Lymphotoxin-alpha LTA 0.0037
1269 Tumor necrosis factor receptor superfamily member 1B TNFRSF1B 0.0037
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0037
4120 NADPH--cytochrome P450 reductase POR 0.0037
183 Vascular endothelial growth factor A VEGFA 0.0036
904 Glutathione S-transferase P GSTP1 0.0036
822 Aldose reductase AKR1B1 0.0036
208 DNA-directed RNA polymerase beta' chain rpoC 0.0036
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0036
833 Organic cation/carnitine transporter 1 SLC22A4 0.0036
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0035
436 5-hydroxytryptamine 2B receptor HTR2B 0.0035
885 5-hydroxytryptamine 1B receptor HTR1B 0.0035
592 Carbonic anhydrase 4 CA4 0.0035
106 Cannabinoid receptor 2 CNR2 0.0035
1010 Cytochrome P450 51A1 CYP51A1 0.0035
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0034
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0034
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0034
518 Peroxidase/catalase T katG 0.0033
68 Cannabinoid receptor 1 CNR1 0.0033
5880 Thrombopoietin receptor MPL 0.0033
4103 Proteasome subunit beta type 2 PSMB2 0.0033
4102 Proteasome subunit beta type 5 PSMB5 0.0033
4101 Proteasome subunit beta type 1 PSMB1 0.0033
4784 Beta-mannosidase manB 0.0032
6695 Beta-mannosidase BT_0458 0.0032
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0032
789 Alpha-1D adrenergic receptor ADRA1D 0.0032
4192 DNA topoisomerase 2-beta TOP2B 0.0031
1227 Cytochrome b MT-CYB 0.0031
6386 Cytochrome b petB 0.0031
6937 Cytochrome b MT-CYB 0.0031
674 Dihydroorotate dehydrogenase homolog, mitochondrial PFF0160c 0.0031
1618 High affinity nerve growth factor receptor NTRK1 0.0031
756 Sex hormone-binding globulin SHBG 0.0031
162 Retinoic acid receptor gamma-1 RARG 0.003
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.003
725 5-hydroxytryptamine 1D receptor HTR1D 0.003
952 Dipeptidyl peptidase 4 DPP4 0.0029
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0029
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0029
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0029
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0029
1792 Tissue-type plasminogen activator PLAT 0.0029
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0029
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0029
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0029
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0029
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0029
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0029
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0029
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0028
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0028
2998 Sialic acid-binding Ig-like lectin 7 SIGLEC7 0.0028
528 5-hydroxytryptamine 1E receptor HTR1E 0.0028
26 Vascular endothelial growth factor receptor 3 FLT4 0.0028
1200 AMBP protein AMBP 0.0028
3866 Serum amyloid A protein SAA1 0.0028
1932 Apolipoprotein E APOE 0.0028
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0027
2207 Rhodopsin RHO 0.0027
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0027
2159 Quinone oxidoreductase CRYZ 0.0027
780 Retinoic acid receptor RXR-gamma RXRG 0.0027
32 Vascular endothelial growth factor receptor 1 FLT1 0.0026
54 Prothrombin F2 0.0026
571 Melatonin receptor type 1A MTNR1A 0.0026
362 Melatonin receptor type 1B MTNR1B 0.0026
663 Solute carrier family 12 member 4 SLC12A4 0.0026
53 Solute carrier family 12 member 5 SLC12A5 0.0026
357 Carbonic anhydrase 2 CA2 0.0026
6126 Carbonic anhydrase 7 CA7 0.0026
6042 Prostaglandin reductase 2 PTGR2 0.0026
6174 50S ribosomal protein L32 rpmF 0.0025
4238 50S ribosomal protein L4 rplD 0.0025
5578 50S ribosomal protein L4 rplD 0.0025
6173 50S ribosomal protein L4 rplD 0.0025
6219 50S ribosomal protein L4 rplD 0.0025
193 Beta-1 adrenergic receptor ADRB1 0.0025
3639 Thymidine phosphorylase deoA 0.0025
3936 Thymidine phosphorylase TYMP 0.0025
1196 Complement decay-accelerating factor CD55 0.0025
3809 Estrogen-related receptor gamma ESRRG 0.0025
4787 Envelope glycoprotein gp160 env 0.0025
4820 Envelope glycoprotein gp160 env 0.0025
5727 Envelope glycoprotein gp160 env 0.0025
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0025
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0025
310 Solute carrier family 12 member 2 SLC12A2 0.0024
482 Glycine receptor subunit alpha-1 GLRA1 0.0024
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0024
3814 Complement C1r subcomponent C1R 0.0024
6138 Multidrug resistance protein 3 ABCB4 0.0024
5300 Antigen peptide transporter 1 TAP1 0.0024
716 5-hydroxytryptamine 7 receptor HTR7 0.0024
2297 Genome polyprotein Not Available 0.0024
2322 Genome polyprotein Not Available 0.0024
2694 Genome polyprotein Not Available 0.0024
2719 Genome polyprotein Not Available 0.0024
2860 Genome polyprotein Not Available 0.0024
2928 Genome polyprotein Not Available 0.0024
3160 Genome polyprotein Not Available 0.0024
3260 Genome polyprotein Not Available 0.0024
4783 Genome polyprotein Not Available 0.0024
5726 Genome polyprotein Not Available 0.0024
5779 Genome polyprotein Not Available 0.0024
5867 Genome polyprotein Not Available 0.0024
6253 Genome polyprotein Not Available 0.0024
6301 Genome polyprotein Not Available 0.0024
6380 Genome polyprotein Not Available 0.0024
6381 Genome polyprotein Not Available 0.0024
6437 Genome polyprotein Not Available 0.0024
6520 Genome polyprotein Not Available 0.0024
6521 Genome polyprotein Not Available 0.0024
6652 Genome polyprotein Not Available 0.0024
6734 Genome polyprotein Not Available 0.0024
6735 Genome polyprotein Not Available 0.0024
6736 Genome polyprotein Not Available 0.0024
6737 Genome polyprotein Not Available 0.0024
6738 Genome polyprotein Not Available 0.0024
6739 Genome polyprotein Not Available 0.0024
6744 Genome polyprotein Not Available 0.0024
6748 Genome polyprotein Not Available 0.0024
6894 Genome polyprotein Not Available 0.0024
6898 Genome polyprotein Not Available 0.0024
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0024
229 Retinoic acid receptor beta RARB 0.0024
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0023
4122 Histone deacetylase 2 HDAC2 0.0023
16 Adenosine A1 receptor ADORA1 0.0023
730 Retinoic acid receptor alpha RARA 0.0023
1178 Adenosine A2a receptor ADORA2A 0.0023
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0023
2782 Complement C1s subcomponent C1S 0.0022
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0022
1374 Natriuretic peptides B NPPB 0.0022
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0022
1827 Gap junction alpha-1 protein GJA1 0.0022
1908 Vascular cell adhesion protein 1 VCAM1 0.0022
638 D(3) dopamine receptor DRD3 0.0022
2808 Chloramphenicol acetyltransferase 3 cat3 0.0022
3480 Mannan endo-1,4-beta-mannosidase manA 0.0022
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0022
3086 Plasmepsin-2 Not Available 0.0022
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0022
84 Nuclear receptor 0B1 NR0B1 0.0022
3437 Eosinophil lysophospholipase CLC 0.0021
1039 Histone deacetylase 9 HDAC9 0.0021
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0021
511 5-hydroxytryptamine 1F receptor HTR1F 0.0021
3817 Complement C1q subcomponent subunit C C1QC 0.0021
3815 Complement C1q subcomponent subunit A C1QA 0.0021
3816 Complement C1q subcomponent subunit B C1QB 0.0021
1102 Low affinity immunoglobulin gamma Fc region receptor III-B FCGR3B 0.0021
3818 Low affinity immunoglobulin gamma Fc region receptor III-A FCGR3A 0.0021
3819 Low affinity immunoglobulin gamma Fc region receptor II-a FCGR2A 0.0021
3821 Low affinity immunoglobulin gamma Fc region receptor II-c FCGR2C 0.0021
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0021
3820 Low affinity immunoglobulin gamma Fc region receptor II-b FCGR2B 0.002
2417 Chloramphenicol acetyltransferase cat 0.002
3278 Chloramphenicol acetyltransferase cat 0.002
469 Annexin A1 ANXA1 0.002
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.002
2810 Dr hemagglutinin structural subunit draA 0.002
153 Dopamine beta-hydroxylase DBH 0.002
1313 Lactoylglutathione lyase GLO1 0.002
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.002
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.002
784 High affinity immunoglobulin gamma Fc receptor I FCGR1A 0.0019
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0019
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0019
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0019
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0019
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0019
581 Cytochrome P450 2R1 CYP2R1 0.0019
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0019
6131 Carbonic anhydrase 14 CA14 0.0019
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0018
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0018
161 Tubulin beta chain TUBB 0.0018
312 Tubulin beta chain TUB2 0.0018
3856 Fibroblast growth factor receptor 3 FGFR3 0.0018
1992 Vitamin D-binding protein GC 0.0018
319 Opioid receptor, sigma 1 OPRS1 0.0017
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0017
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0017
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0017
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0017
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0017
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0017
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0017
1144 Hepatocyte growth factor receptor MET 0.0017
2112 Toll-like receptor 9 TLR9 0.0017
594 Thyroxine-binding globulin SERPINA7 0.0017
992 Protein tyrosine kinase 2 beta PTK2B 0.0017
976 Platelet glycoprotein IX GP9 0.0017
1630 Integrin beta-2 ITGB2 0.0017
1864 RET proto-oncogene RET 0.0017
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0016
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0016
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0016
629 Alpha-2B adrenergic receptor ADRA2B 0.0016
165 FL cytokine receptor FLT3 0.0016
124 Histamine H2 receptor HRH2 0.0016
5787 Angiopoietin-1 receptor TEK 0.0016
4226 Uridine phosphorylase 2 UPP2 0.0016
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0016
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0016
6163 Copper-transporting ATPase 2 ATP7B 0.0016
6165 Copper-transporting ATPase 1 ATP7A 0.0016
4217 Telomerase reverse transcriptase TERT 0.0016
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0016
814 Ryanodine receptor 1 RYR1 0.0016
4311 tRNA TRDMT1 0.0016
4325 tRNA trmD 0.0016
4328 tRNA trmD 0.0016
758 Thyroid hormone receptor alpha THRA 0.0015
239 Coagulation factor X F10 0.0015
4785 Ig gamma-1 chain C region IGHG1 0.0015
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0015
164 Histamine H4 receptor HRH4 0.0015
4948 Cytochrome c-553 Not Available 0.0015
4923 Cytochrome c3 DvMF_2499 0.0015
4945 Cytochrome c3 Not Available 0.0015
4949 Cytochrome c3 DVU_3171 0.0015
4968 Cytochrome c3 cytc3 0.0015
4997 Cytochrome c3 SO_2727 0.0015
5219 Cytochrome c3 cyd 0.0015
3189 High-molecular-weight cytochrome c hmcA 0.0015
4902 Nine-heme cytochrome c Ddes_2038 0.0015
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0015
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0015
174 Sigma 1-type opioid receptor SIGMAR1 0.0015
4225 Uridine phosphorylase 1 UPP1 0.0015
6020 Aldehyde oxidase AOX1 0.0015
3611 Cytidine deaminase cdd 0.0014
3707 Cytidine deaminase cdd 0.0014
4211 Cytidine deaminase CDA 0.0014
199 Monocarboxylate transporter 8 SLC16A2 0.0014
6048 Troponin C, skeletal muscle TNNC2 0.0014
2539 Tubulin alpha-1 chain TUBA4A 0.0014
719 Retinoic acid receptor responder protein 1 RARRES1 0.0014
770 Retinoic acid-induced protein 3 GPRC5A 0.0014
268 Adenosine A2b receptor ADORA2B 0.0014
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0014
413 Amidophosphoribosyltransferase PPAT 0.0014
2515 Amidophosphoribosyltransferase purF 0.0014
3714 Amidophosphoribosyltransferase purF 0.0014
6044 Serum paraoxonase/lactonase 3 PON3 0.0014
346 Thyroid hormone receptor beta-1 THRB 0.0014
2232 Interleukin-5 IL5 0.0014
1291 cAMP response element-binding protein CREB1 0.0014
1593 Mucin-2 MUC2 0.0014
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0013
856 Vitamin D3 receptor VDR 0.0013
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0013
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0013
896 Glutathione S-transferase Mu 1 GSTM1 0.0013
432 D(4) dopamine receptor DRD4 0.0013
4386 Hemoglobin-like protein HbN glbN 0.0013
4210 Toll-like receptor 4 TLR4 0.0013
3932 Glutathione S-transferase A2 GSTA2 0.0013
1262 Corticotropin-lipotropin POMC 0.0013
572 Integrin alpha-L ITGAL 0.0013
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0013
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0013
4943 Cytochrome c6 petJ 0.0013
4954 Soluble cytochrome b558 Not Available 0.0013
4934 Cytochrome c-551 nirM 0.0013
5218 Cytochrome c-551 nirM 0.0013
4905 Cytochrome c2 Not Available 0.0013
4939 Cytochrome c2 cycA 0.0013
4964 Cytochrome c2 cycA 0.0013
4979 Cytochrome c2 cycA 0.0013
6673 Cytochrome c2 cycA 0.0013
4947 Bacterial hemoglobin vhb 0.0013
4925 Cytochrome c-type protein SHP shp 0.0013
4984 Neuroglobin NGB 0.0013
4916 Cyanoglobin glbN 0.0013
4994 Hemoglobin-like protein HbO glbO 0.0013
4915 Cytochrome c-550 psbV 0.0013
4959 Cytochrome c-550 psbV 0.0013
5216 Cytochrome c-550 psbV 0.0013
4998 Hemoglobin-like protein yjbI yjbI 0.0013
4942 Diheme cytochrome c napB napB 0.0013
4975 Cytochrome c-556 RPA3973 0.0013
4936 Cytochrome c2 iso-2 Not Available 0.0013
4961 Hemophore HasA hasA 0.0013
5798 Mitogen-activated protein kinase 11 MAPK11 0.0013
5923 Microtubule-associated protein tau MAPT 0.0013
4910 Cytoglobin CYGB 0.0013
5000 HemO hemO 0.0013
644 Heme oxygenase 2 HMOX2 0.0013
4982 Heme oxygenase 2 pbsA2 0.0013
4904 Cytochrome c family protein GSU1996 0.0013
4981 Iron-starvation protein PigA pigA 0.0013
4909 CooA protein cooA 0.0013
3116 Bacterioferritin bfr 0.0013
4906 Bacterioferritin bfr 0.0013
4965 Bacterioferritin bfr 0.0013
4907 Cytochrome c-L moxG 0.0013
6865 Cytochrome c-L moxG 0.0013
5924 Microtubule-associated protein 4 MAP4 0.0013
4976 Apocytochrome f petA 0.0012
6407 Apocytochrome f petA 0.0012
4971 Nonaheme cytochrome c hmcA 0.0012
4764 Cytochrome P450 165C4 CYP165C4 0.0012
4989 Cytochrome c551 peroxidase ccp 0.0012
5222 Cytochrome c551 peroxidase ccpA 0.0012
4937 Cytochrome oxidase subunit II rcoxA 0.0012
4935 Cytochrome c-554 cycA1 0.0012
4999 Cytochrome P450 165B3 CYP165B3 0.0012
4926 Heme-based aerotactic transducer hemAT hemAT 0.0012
4960 Putative cytochrome P450-family protein SCO7417 0.0012
4931 Cytochrome P450 167A1 CYP167A1 0.0012
4993 Hydroxylamine oxidoreductase hao1 0.0012
4972 P450cin cinA 0.0012
4922 Cytochrome c, putative SO_4144 0.0012
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0012
4903 Methyl-accepting chemotaxis protein Tar4 0.0012
4952 Catalase/peroxidase katA 0.0012
3093 Catalase HPII katE 0.0012
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0012
2320 Thymidine kinase, cytosolic TK1 0.0012
267 Plasminogen activator inhibitor 1 SERPINE1 0.0012
569 Retinal dehydrogenase 2 ALDH1A2 0.0012
3221 Cytochrome c4 cc4 0.0012
5433 UPF0230 protein TM_1468 TM_1468 0.0012
5431 Lipid binding protein Not Available 0.0012
3616 Fatty acid-binding protein, epidermal FABP5 0.0012
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0012
1852 Microtubule-associated protein 2 MAP2 0.0012
611 Retinal dehydrogenase 1 ALDH1A1 0.0012
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0012
474 Acetylcholinesterase ACHE 0.0011
6218 Pannexin-1 PANX1 0.0011
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0011
6221 Steroid hormone receptor ERR1 ESRRA 0.0011
1123 Eosinophil cationic protein RNASE3 0.0011
5934 Cytochrome P450 26A1 CYP26A1 0.0011
3913 Glutamic acid decarboxylase GAD65 0.0011
751 Potassium channel subfamily K member 6 KCNK6 0.0011
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0011
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0011
3917 Methylenetetrahydrofolate reductase MTHFR 0.001
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.001
1483 Membrane copper amine oxidase AOC3 0.001
3937 Fatty-acid amide hydrolase FAAH 0.001
563 Thyroid peroxidase TPO 0.001
283 SEC14-like protein 2 SEC14L2 0.001
172 Potassium channel subfamily K member 1 KCNK1 0.001
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.001
6837 Serine/threonine-protein kinase 17B STK17B 0.001
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.001
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.001
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.001
936 Ephrin type-A receptor 2 EPHA2 0.001
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.001
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.001
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0009
2211 Fatty acid-binding protein, heart FABP3 0.0009
6459 Glycodelin PAEP 0.0009
4920 Peroxidase/catalase katG 0.0009
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0009
2216 Fibroblast growth factor receptor 4 FGFR4 0.0009
2119 Cytochrome b5 CYB5A 0.0009
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0009
4037 Hypothetical protein GPX1 0.0009
4297 Hypothetical protein SP_1951 0.0009
4521 Hypothetical protein BC_2969 0.0009
4540 Hypothetical protein TM_1070 0.0009
4555 Hypothetical protein MT1739 0.0009
4569 Hypothetical protein mshD 0.0009
4578 Hypothetical protein PA3270 0.0009
4747 Hypothetical protein PA3967 0.0009
5177 Hypothetical protein TM_0096 0.0009
5194 Hypothetical protein PA1204 0.0009
5240 Hypothetical protein Rv2991 0.0009
5370 Hypothetical protein TM_1158 0.0009
5710 Hypothetical protein Tb927.5.1360 0.0009
4990 PpcA ppcA 0.0009
735 Alanine aminotransferase 1 GPT 0.0009
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0009
3904 Alanine aminotransferase 2 GPT2 0.0009
4289 Cytochrome P450 TT_P0059 0.0009
6262 Cytochrome P450 staP 0.0009
3570 Cytochrome P450 152A1 cypC 0.0009
4988 Sulfite oxidase, mitochondrial SUOX 0.0009
4992 Cytochrome c peroxidase Not Available 0.0009
2915 Sensor protein fixL fixL 0.0009
4944 Sensor protein fixL fixL 0.0009
3957 Adenosine deaminase ADA 0.0009
3375 Acidic cytochrome c3 Not Available 0.0009
4385 Cytochrome c' Not Available 0.0009
4967 Cytochrome c' cycA 0.0009
5038 Cytochrome c' Not Available 0.0009
5223 Cytochrome c' cycP 0.0009
4813 Heme oxygenase hmuO 0.0009
5769 Heme oxygenase Not Available 0.0009
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0009
1341 Histamine H3 receptor HRH3 0.0009
537 ATP synthase delta chain, mitochondrial ATP5D 0.0009
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0009
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0009
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0009
2230 Catalase CAT 0.0009
3249 Catalase katA 0.0009
3625 Catalase katA 0.0009
4539 Catalase katA 0.0009
4941 Catalase katB 0.0009
6677 Myelin P2 protein PMP2 0.0009
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0009
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0009
284 DNA-directed RNA polymerase beta chain rpoB 0.0008
5773 DNA-directed RNA polymerase beta chain rpoB 0.0008
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0008
1184 Interferon beta IFNB1 0.0008
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0008
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0008
378 Alpha-2C adrenergic receptor ADRA2C 0.0008
3670 Soluble cytochrome b562 precursor cybC 0.0008
3411 Cytochrome P450 121 cyp121 0.0008
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0008
2617 Nitric oxide synthase oxygenase nos 0.0008
2701 Nitric oxide synthase oxygenase nos 0.0008
3291 Cytochrome c-552 cycA 0.0008
4927 Cytochrome c-552 nrfA 0.0008
4938 Cytochrome c-552 cycA 0.0008
4953 Cytochrome c-552 nrfA 0.0008
5217 Cytochrome c-552 cycM 0.0008
3102 Flavohemoprotein hmp 0.0008
4969 Flavohemoprotein hmp 0.0008
6599 HTH-type transcriptional regulator ttgR ttgR 0.0008
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0008
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0008
3830 Calreticulin CALR 0.0008
4773 Deoxycytidine kinase DCK 0.0008
2599 Tyrosine-protein kinase HCK HCK 0.0007
1256 5-hydroxytryptamine 6 receptor HTR6 0.0007
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0007
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0007
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0007
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0007
605 Fumarate reductase flavoprotein subunit frdA 0.0007
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0007
3673 Fumarate reductase flavoprotein subunit fccA 0.0007
4912 Fumarate reductase flavoprotein subunit ifcA 0.0007
6549 Fumarate reductase flavoprotein subunit frdA 0.0007
2972 6-deoxyerythronolide B hydroxylase eryF 0.0007
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0007
76 Nitric-oxide synthase, brain NOS1 0.0007
6034 Hydroxyindole O-methyltransferase ASMT 0.0007
6035 Nuclear receptor ROR-beta RORB 0.0007
6824 Tyrosine-protein kinase Lyn LYN 0.0007
6036 Eosinophil peroxidase EPX 0.0007
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0007
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0007
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0007
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0007
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0007
4608 Putative cytochrome P450 SCO1207 0.0007
4963 Putative cytochrome P450 SCO2884 0.0007
6254 Putative cytochrome P450 SCO6998 0.0007
4666 Fucose-binding lectin PA-IIL lecB 0.0007
2372 Bifunctional tail protein 9 0.0007
760 Fibroblast growth factor 1 FGF1 0.0007
358 Cystathionine beta-synthase CBS 0.0006
4878 Glycoprotein hormones alpha chain CGA 0.0006
1052 Cytotoxic T-lymphocyte protein 4 CTLA4 0.0006
1072 Granzyme B GZMB 0.0006
4871 Endo-beta-N-acetylglucosaminidase F3 endOF3 0.0006
4880 Membrane cofactor protein CD46 0.0006
4889 Ig epsilon chain C region IGHE 0.0006
4877 Beta-mannanase man 0.0006
1563 Platelet glycoprotein Ib alpha chain GP1BA 0.0006
4850 Beta-2-glycoprotein 1 APOH 0.0006
4856 CD209 antigen CD209 0.0006
4189 Alpha-galactosidase A GLA 0.0006
4869 Major capsid protein A430L 0.0006
757 Fusion glycoprotein F0 F 0.0006
4875 Fusion glycoprotein F0 F 0.0006
4852 Reticulon-4 receptor RTN4R 0.0006
4845 ADAM 33 ADAM33 0.0006
1354 Beta-glucuronidase GUSB 0.0006
442 Envelope glycoprotein gp41 0.0006
4859 Envelope glycoprotein env 0.0006
4882 Dipeptidyl aminopeptidase-like protein 6 DPP6 0.0006
4721 Beta-1,4-mannanase manA 0.0006
3352 Structural polyprotein Not Available 0.0006
3628 Structural polyprotein Not Available 0.0006
4892 Structural polyprotein Not Available 0.0006
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0006
251 Alcohol dehydrogenase 1A ADH1A 0.0006
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0006
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0006
693 Hemoglobin subunit beta HBB 0.0006
765 Indoleamine 2,3-dioxygenase IDO1 0.0006
705 Glutamate receptor 1 GRIA1 0.0006
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0006
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0006
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0006
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0006
820 Glycine receptor subunit alpha-2 GLRA2 0.0006
6268 Hydroxyacid oxidase 1 HAO1 0.0006
163 D(1B) dopamine receptor DRD5 0.0006
810 Heme oxygenase 1 HMOX1 0.0006
3391 Heme oxygenase 1 pbsA1 0.0006
4193 Atrial natriuretic peptide clearance receptor NPR3 0.0006
793 T-cell surface antigen CD2 CD2 0.0006
4861 Interleukin-6 receptor alpha chain IL6R 0.0006
119 Carcinoembryonic antigen-related cell adhesion molecule 1 CEACAM1 0.0006
3837 Cytokine receptor common beta chain CSF2RB 0.0006
5221 Cytochrome c3, 13 kDa Not Available 0.0006
3152 Cytochrome c'' cycA 0.0006
5220 Split-Soret cytochrome c Ddes_2150 0.0006
3700 Cytochrome c-552 precursor nrfA 0.0006
444 Alcohol dehydrogenase 1B ADH1B 0.0005
2430 Chondroitinase B cslB 0.0005
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0005
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0005
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0005
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0005
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0005
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0005
2298 Cytochrome P450-cam camC 0.0005
6151 Monocarboxylate transporter 10 SLC16A10 0.0005
1379 Interleukin-12 subunit beta IL12B 0.0005
4890 Hemagglutinin HA 0.0005
6566 Hemagglutinin Not Available 0.0005
3127 Nitrite reductase nirS 0.0005
3284 Nitrite reductase nirS 0.0005
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0005
1268 Neuropeptide S receptor NPSR1 0.0005
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0005
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0005
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0005
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0005
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0005
4857 Zinc-alpha-2-glycoprotein AZGP1 0.0005
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0005
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0005
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0005
6858 Inactive carboxylesterase 4 CES1P1 0.0005
517 Alcohol dehydrogenase 1C ADH1C 0.0005
6120 Cation-independent mannose-6-phosphate receptor IGF2R 0.0005
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0005
18 High affinity immunoglobulin epsilon receptor subunit alpha FCER1A 0.0005
554 Low-density lipoprotein receptor LDLR 0.0004
852 Heparin cofactor 2 SERPIND1 0.0004
6073 Potassium channel subfamily K member 9 KCNK9 0.0004
6072 Potassium channel subfamily K member 3 KCNK3 0.0004
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0004
3405 Quinohaemoprotein ethanol dehydrogenase type-1 qheDH 0.0004
1859 Prostatic acid phosphatase ACPP 0.0004
595 Fibrinogen alpha chain FGA 0.0004
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0004
3140 Hemagglutinin-neuraminidase HN 0.0004
3609 Hemagglutinin-neuraminidase HN 0.0004
3444 Cyanovirin-N Not Available 0.0004
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0004
3258 Mannosyl-oligosaccharide alpha-1,2-mannosidase MSDC 0.0004
4509 Acetoin(diacetyl) reductase budC 0.0004
958 Insulin-like growth factor 1 receptor IGF1R 0.0004
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0004
3689 Endoglucanase A celA 0.0004
3009 Beta-glucanase Not Available 0.0004
5411 Slt-IIvB stxB2e 0.0004
5565 Inorganic polyphosphate/ATP-glucomannokinase ppgmk 0.0004
5563 Galectin-2 LGALS2 0.0004
1875 Pulmonary surfactant-associated protein D SFTPD 0.0004
5569 Endo-1,4-beta glucanase EngF engF 0.0004
5046 Ecotin eco 0.0004
3793 Aspartate ammonia-lyase aspA 0.0004
5554 D-galactose-binding periplasmic protein mglB 0.0004
3741 D-galactose-binding periplasmic protein precursor mglB 0.0004
5568 Endoglucanase C307 celC307 0.0004
5553 Endoglucanase E1 Acel_0614 0.0004
5562 Hexokinase Not Available 0.0004
3744 Endoglucanase SS precursor celS 0.0004
5570 Endoglucanase E-4 celD 0.0004
5559 Neopullulanase nplT 0.0004
4670 Cellulase B celB 0.0004
4668 Laminarinase TM_0024 0.0004
4667 BH0236 protein BH0236 0.0004
4671 Endoglucanase C cenC 0.0004
64 Neuraminidase NA 0.0004
641 Neuraminidase NA 0.0004
2676 Neuraminidase NA 0.0004
3026 Neuraminidase NA 0.0004
3519 Neuraminidase NA 0.0004
6007 Neuraminidase NA 0.0004
2577 Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase MAN1B1 0.0004
1243 Cathepsin D CTSD 0.0003
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0003
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0003
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0003
309 Antithrombin-III SERPINC1 0.0003
1782 Neutrophil gelatinase-associated lipocalin LCN2 0.0003
5176 YtnJ moxC 0.0003
5416 Coat protein VP1 Not Available 0.0003
2705 Dimethyl sulfoxide reductase dmsA 0.0003
5247 Endo-1,4-beta-xylanase Not Available 0.0003
5248 Endo-1,4-beta-xylanase xlnA 0.0003
5250 Endo-1,4-beta-xylanase xyl 0.0003
4669 Endo-1,4-beta-xylanase A xynA 0.0003
4715 Endo-1,4-beta-xylanase A xlnA 0.0003
5560 Endo-1,4-beta-xylanase A xynA 0.0003
1503 Galectin-7 LGALS7 0.0003
5498 Maltoporin lamB 0.0003
5561 Maltoporin lamB 0.0003
5056 Maltooligosyltrehalose trehalohydrolase, putative treZ 0.0003
3525 ADP-ribose pyrophosphatase, mitochondrial NUDT9 0.0003
4622 Amylase Not Available 0.0003
2728 Glucan 1,4-alpha-maltotetraohydrolase amyP 0.0003
6307 Ig gamma-2 chain C region IGHG2 0.0003
2826 Glucose--fructose oxidoreductase gfo 0.0003
1881 Hexokinase-1 HK1 0.0003
2581 Chondroitinase AC cslA 0.0003
6847 Lactase-phlorizin hydrolase LCT 0.0003
2324 Botulinum neurotoxin type B botB 0.0003
3153 Quinoprotein glucose dehydrogenase-B gdhB 0.0003
3747 Cellulase B precursor celB 0.0003
3547 Enterotoxin type B entB 0.0003
2856 Glucosamine-6-phosphate isomerase GNPDA1 0.0003
2564 Glucan 1,4-alpha-maltohexaosidase Not Available 0.0003
4819 Hydrolase Not Available 0.0003
5249 Hydrolase Not Available 0.0003
5436 Hydrolase Not Available 0.0003
2531 Alpha-amylase amyE 0.0003
2948 Alpha-amylase amy 0.0003
3169 Alpha-amylase Not Available 0.0003
2541 Neopullulanase 1 tvaI 0.0003
4811 Amylosucrase ams 0.0003
3091 Maltodextrin phosphorylase malP 0.0003
2606 Neopullulanase 2 tvaII 0.0003
4692 A/G-specific adenine glycosylase mutY 0.0003
3225 Shiga toxin B-chain stxB 0.0003
3365 Beta-amylase spoII 0.0003
4830 Aldose 1-epimerase galM 0.0003
6614 Lactase-like protein LCTL 0.0003
1675 Glucokinase GCK 0.0003
4662 Glucokinase glk 0.0003
3030 Salivary alpha-amylase AMY1A 0.0003
2293 Cyclomaltodextrin glucanotransferase Not Available 0.0003
2508 Cyclomaltodextrin glucanotransferase cgt 0.0003
2523 Cyclomaltodextrin glucanotransferase cgt 0.0003
3207 Cyclomaltodextrin glucanotransferase amyA 0.0003
4272 POSSIBLE CELLULASE CELA1 celA1 0.0003
2570 Tetanus toxin tetX 0.0002
2448 Exoglucanase/xylanase [Includes: Exoglucanase cex 0.0002
3668 Maltose-binding periplasmic protein precursor malE 0.0002
2802 Endoglucanase G celCCG 0.0002
2440 Endoglucanase F celCCF 0.0002
2245 Xylose isomerase xylA 0.0002
2253 Xylose isomerase xylA 0.0002
2260 Xylose isomerase xylA 0.0002
2431 Xylose isomerase xylA 0.0002
2252 Endoglucanase 5A cel5A 0.0002
10 Glycogen phosphorylase, liver form PYGL 0.0002
2723 Cholera enterotoxin subunit B ctxB 0.0002
4513 Pancreatic alpha-amylase AMY2A 0.0002
2427 Ferrichrome-iron receptor fhuA 0.0002
1152 Glycogen phosphorylase, muscle form PYGM 0.0002
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