DT-Web

DB07008 - 4-(1,3-BENZODIOXOL-5-YLOXY)-2-[4-(1H-IMIDAZOL-1-YL)PHENOXY]PYRIMIDINE


Identification
Name 4-(1,3-BENZODIOXOL-5-YLOXY)-2-[4-(1H-IMIDAZOL-1-YL)PHENOXY]PYRIMIDINE
Accession Number DB07008
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 374.3496
Groups experimental
Monoisotopic Weight 374.101504956
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Nitric oxide synthase, inducible
Name Nitric oxide synthase, inducible
Gene Name NOS2
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.1398

Predictions


Id Partner name Gene Name Score
291 Nitric-oxide synthase, endothelial NOS3 0.164
76 Nitric-oxide synthase, brain NOS1 0.0987
828 Phenylalanine-4-hydroxylase PAH 0.0212
3109 Phenylalanine-4-hydroxylase phhA 0.0212
134 Tryptophan 5-hydroxylase 1 TPH1 0.018
2617 Nitric oxide synthase oxygenase nos 0.0145
2701 Nitric oxide synthase oxygenase nos 0.0145
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0136
6144 Solute carrier family 22 member 2 SLC22A2 0.0132
2675 Pteridine reductase 1 PTR1 0.0128
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0125
2360 Dihydroneopterin aldolase folB 0.0107
315 Arginase-1 ARG1 0.0101
676 Tyrosine 3-monooxygenase TH 0.0095
740 Argininosuccinate synthase ASS1 0.007
865 Argininosuccinate synthase ASS1 0.007
2680 Argininosuccinate synthase argG 0.007
3194 Argininosuccinate synthase argG 0.007
20 Prostaglandin G/H synthase 1 PTGS1 0.0067
577 Argininosuccinate lyase ASL 0.0051
1814 Protein-arginine deiminase type-4 PADI4 0.0048
843 NG,NG-dimethylarginine dimethylaminohydrolase 1 DDAH1 0.0045
670 NG,NG-dimethylarginine dimethylaminohydrolase 2 DDAH2 0.0045
4066 Protein-arginine deiminase type-1 PADI1 0.0045
4068 Protein-arginine deiminase type-2 PADI2 0.0045
4067 Protein-arginine deiminase type-3 PADI3 0.0045
4065 Protein-arginine deiminase type-6 PADI6 0.0045
834 Arginase-2, mitochondrial ARG2 0.0045
499 Arginine decarboxylase ADC 0.0042
336 Ornithine carbamoyltransferase, mitochondrial OTC 0.0042
150 Cationic amino acid transporter 3 SLC7A3 0.0039
235 High-affinity cationic amino acid transporter 1 SLC7A1 0.0039
58 Cationic amino acid transporter 4 SLC7A4 0.0039
6030 Cytochrome P450 2B6 CYP2B6 0.0029
6151 Monocarboxylate transporter 10 SLC16A10 0.0027
833 Organic cation/carnitine transporter 1 SLC22A4 0.0027
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0024
1588 Multidrug resistance protein 1 ABCB1 0.0023
118 Organic cation/carnitine transporter 2 SLC22A5 0.0023
776 Bile salt export pump ABCB11 0.0023
3811 Cytochrome P450 19A1 CYP19A1 0.0023
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0022
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0022
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0022
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0022
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0022
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0022
1898 Cytochrome P450 1B1 CYP1B1 0.0022
4119 Cytochrome P450 2D6 CYP2D6 0.0022
4512 Cytochrome P450 3A4 CYP3A4 0.0022
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0021
5718 Cytochrome P450 2A6 CYP2A6 0.002
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.002
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.002
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0019
84 Nuclear receptor 0B1 NR0B1 0.0019
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0018
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0018
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0018
6168 Solute carrier family 22 member 16 SLC22A16 0.0018
6013 Cytochrome P450 2E1 CYP2E1 0.0018
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0017
469 Annexin A1 ANXA1 0.0017
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0017
380 Cytochrome P450 17A1 CYP17A1 0.0017
4757 Cytochrome P450 2C9 CYP2C9 0.0017
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0017
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0016
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0016
6016 Cytochrome P450 2C19 CYP2C19 0.0016
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0015
4120 NADPH--cytochrome P450 reductase POR 0.0015
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0014
260 Cytochrome P450 51 ERG11 0.0014
761 Cytochrome P450 51 ERG11 0.0014
3163 Cytochrome P450 51 cyp51 0.0014
468 Cytochrome P450 4A11 CYP4A11 0.0014
6031 Cytochrome P450 3A43 CYP3A43 0.0014
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0013
6137 Multidrug resistance-associated protein 6 ABCC6 0.0013
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0013
6148 Multidrug resistance-associated protein 7 ABCC10 0.0013
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0013
3947 Xanthine dehydrogenase/oxidase XDH 0.0012
817 DNA topoisomerase 2-alpha TOP2A 0.0012
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0012
871 Glucocorticoid receptor NR3C1 0.0011
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0011
862 Multidrug resistance-associated protein 1 ABCC1 0.001
4924 Cytochrome P450 2C8 CYP2C8 0.001
6024 Cytochrome P450 1A1 CYP1A1 0.0009
6107 Cytochrome P450 3A7 CYP3A7 0.0009
4118 Cytochrome P450 3A5 CYP3A5 0.0008
4200 Cytochrome P450 1A2 CYP1A2 0.0008
4998 Hemoglobin-like protein yjbI yjbI 0.0008
4934 Cytochrome c-551 nirM 0.0008
5218 Cytochrome c-551 nirM 0.0008
4936 Cytochrome c2 iso-2 Not Available 0.0008
4981 Iron-starvation protein PigA pigA 0.0008
4994 Hemoglobin-like protein HbO glbO 0.0008
4915 Cytochrome c-550 psbV 0.0008
4959 Cytochrome c-550 psbV 0.0008
5216 Cytochrome c-550 psbV 0.0008
4925 Cytochrome c-type protein SHP shp 0.0008
4909 CooA protein cooA 0.0008
4947 Bacterial hemoglobin vhb 0.0008
4942 Diheme cytochrome c napB napB 0.0008
4984 Neuroglobin NGB 0.0008
4943 Cytochrome c6 petJ 0.0008
3116 Bacterioferritin bfr 0.0008
4906 Bacterioferritin bfr 0.0008
4965 Bacterioferritin bfr 0.0008
4954 Soluble cytochrome b558 Not Available 0.0008
4961 Hemophore HasA hasA 0.0008
4905 Cytochrome c2 Not Available 0.0008
4939 Cytochrome c2 cycA 0.0008
4964 Cytochrome c2 cycA 0.0008
4979 Cytochrome c2 cycA 0.0008
6673 Cytochrome c2 cycA 0.0008
4910 Cytoglobin CYGB 0.0008
4907 Cytochrome c-L moxG 0.0008
6865 Cytochrome c-L moxG 0.0008
4916 Cyanoglobin glbN 0.0008
5000 HemO hemO 0.0008
4935 Cytochrome c-554 cycA1 0.0008
644 Heme oxygenase 2 HMOX2 0.0008
4982 Heme oxygenase 2 pbsA2 0.0008
4764 Cytochrome P450 165C4 CYP165C4 0.0008
4975 Cytochrome c-556 RPA3973 0.0008
4922 Cytochrome c, putative SO_4144 0.0008
4952 Catalase/peroxidase katA 0.0008
4972 P450cin cinA 0.0008
4937 Cytochrome oxidase subunit II rcoxA 0.0008
4971 Nonaheme cytochrome c hmcA 0.0008
4989 Cytochrome c551 peroxidase ccp 0.0008
5222 Cytochrome c551 peroxidase ccpA 0.0008
4976 Apocytochrome f petA 0.0008
6407 Apocytochrome f petA 0.0008
4904 Cytochrome c family protein GSU1996 0.0008
4993 Hydroxylamine oxidoreductase hao1 0.0008
4999 Cytochrome P450 165B3 CYP165B3 0.0008
4960 Putative cytochrome P450-family protein SCO7417 0.0008
4931 Cytochrome P450 167A1 CYP167A1 0.0008
4926 Heme-based aerotactic transducer hemAT hemAT 0.0008
4903 Methyl-accepting chemotaxis protein Tar4 0.0008
3093 Catalase HPII katE 0.0008
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0008
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0008
4990 PpcA ppcA 0.0007
4037 Hypothetical protein GPX1 0.0007
4297 Hypothetical protein SP_1951 0.0007
4521 Hypothetical protein BC_2969 0.0007
4540 Hypothetical protein TM_1070 0.0007
4555 Hypothetical protein MT1739 0.0007
4569 Hypothetical protein mshD 0.0007
4578 Hypothetical protein PA3270 0.0007
4747 Hypothetical protein PA3967 0.0007
5177 Hypothetical protein TM_0096 0.0007
5194 Hypothetical protein PA1204 0.0007
5240 Hypothetical protein Rv2991 0.0007
5370 Hypothetical protein TM_1158 0.0007
5710 Hypothetical protein Tb927.5.1360 0.0007
4385 Cytochrome c' Not Available 0.0007
4967 Cytochrome c' cycA 0.0007
5038 Cytochrome c' Not Available 0.0007
5223 Cytochrome c' cycP 0.0007
3570 Cytochrome P450 152A1 cypC 0.0007
4289 Cytochrome P450 TT_P0059 0.0007
6262 Cytochrome P450 staP 0.0007
4992 Cytochrome c peroxidase Not Available 0.0007
4948 Cytochrome c-553 Not Available 0.0007
4813 Heme oxygenase hmuO 0.0007
5769 Heme oxygenase Not Available 0.0007
4920 Peroxidase/catalase katG 0.0007
4923 Cytochrome c3 DvMF_2499 0.0007
4945 Cytochrome c3 Not Available 0.0007
4949 Cytochrome c3 DVU_3171 0.0007
4968 Cytochrome c3 cytc3 0.0007
4997 Cytochrome c3 SO_2727 0.0007
5219 Cytochrome c3 cyd 0.0007
2119 Cytochrome b5 CYB5A 0.0007
4902 Nine-heme cytochrome c Ddes_2038 0.0007
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0007
3189 High-molecular-weight cytochrome c hmcA 0.0007
2915 Sensor protein fixL fixL 0.0007
4944 Sensor protein fixL fixL 0.0007
3375 Acidic cytochrome c3 Not Available 0.0007
4988 Sulfite oxidase, mitochondrial SUOX 0.0007
4386 Hemoglobin-like protein HbN glbN 0.0006
3670 Soluble cytochrome b562 precursor cybC 0.0006
3291 Cytochrome c-552 cycA 0.0006
4927 Cytochrome c-552 nrfA 0.0006
4938 Cytochrome c-552 cycA 0.0006
4953 Cytochrome c-552 nrfA 0.0006
5217 Cytochrome c-552 cycM 0.0006
3102 Flavohemoprotein hmp 0.0006
4969 Flavohemoprotein hmp 0.0006
3411 Cytochrome P450 121 cyp121 0.0006
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0006
3221 Cytochrome c4 cc4 0.0006
3127 Nitrite reductase nirS 0.0006
3284 Nitrite reductase nirS 0.0006
2230 Catalase CAT 0.0006
3249 Catalase katA 0.0006
3625 Catalase katA 0.0006
4539 Catalase katA 0.0006
4941 Catalase katB 0.0006
4608 Putative cytochrome P450 SCO1207 0.0005
4963 Putative cytochrome P450 SCO2884 0.0005
6254 Putative cytochrome P450 SCO6998 0.0005
605 Fumarate reductase flavoprotein subunit frdA 0.0005
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0005
3673 Fumarate reductase flavoprotein subunit fccA 0.0005
4912 Fumarate reductase flavoprotein subunit ifcA 0.0005
6549 Fumarate reductase flavoprotein subunit frdA 0.0005
2972 6-deoxyerythronolide B hydroxylase eryF 0.0005
1507 Cytochrome c CYCS 0.0005
518 Peroxidase/catalase T katG 0.0005
693 Hemoglobin subunit beta HBB 0.0005
6268 Hydroxyacid oxidase 1 HAO1 0.0005
810 Heme oxygenase 1 HMOX1 0.0004
3391 Heme oxygenase 1 pbsA1 0.0004
2298 Cytochrome P450-cam camC 0.0004
358 Cystathionine beta-synthase CBS 0.0004
275 Arachidonate 5-lipoxygenase ALOX5 0.0003
6106 Cytochrome P450 2C18 CYP2C18 0.0003
290 Prostaglandin G/H synthase 2 PTGS2 0.0002
587 Serum albumin ALB 0.0002
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