DT-Web

DB00041 - Aldesleukin


Identification
Name Aldesleukin
Accession Number DB00041 (BIOD00082, BTD00082)
Type biotech
Description Aldesleukin, a lymphokine, is produced by recombinant DNA technology using a genetically engineered E. coli strain containing an analog of the human interleukin-2 gene. Genetic engineering techniques were used to modify the human IL-2 gene, and the resulting expression clone encodes a modified human interleukin-2. This recombinant form differs from native interleukin-2 in the following ways: a) Aldesleukin is not glycosylated because it is derived from E. coli; b) the molecule has no N-terminal alanine; the codon for this amino acid was deleted during the genetic engineering procedure; c) the molecule has serine substituted for cysteine at amino acid position 125.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 15314.8000
Groups approved
Monoisotopic Weight Not Available
Pharmacology
Indication For treatment of adults with metastatic renal cell carcinoma.
Mechanism of action Aldesleukin binds to the IL-2 receptor which leads to heterodimerization of the cytoplasmic domains of the IL-2R beta and gamma(c) chains, activation of the tyrosine kinase Jak3, and phosphorylation of tyrosine residues on the IL-2R beta chain. These events led to the creation of an activated receptor complex, to which various cytoplasmic signaling molecules are recruited and become substrates for regulatory enzymes (especially tyrosine kinases) that are associated with the receptor. These events stimulate growth and differentiation of T cells.
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination The pharmacokinetic profile of Proleukin is characterized by high plasma concentrations following a short IV infusion, rapid distribution into the extravascular space and elimination from the body by metabolism in the kidneys with little or no bioactive protein excreted in the urine. Following the initial rapid organ distribution, the primary route of clearance of circulating proleukin is the kidney. Greater than 80% of the amount of Proleukin distributed to plasma, cleared from the circulation and presented to the kidney is metabolized to amino acids in the cells lining the proximal convoluted tubules.
Toxicity Not Available
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Clobetasol Corticosteroids such as clobetasol may diminish the antineoplastic effect of aldesleukin. Avoid conccurent use of corticosteroids with aldesleukin.
Clocortolone Corticosteroids such as clocortolone may diminish the antineoplastic effect of aldesleukin. Avoid conccurent use of corticosteroids with aldesleukin.
Corticotropin Corticosteroids may diminish the antineoplastic effect of Aldesleukin. Avoid conccurent use of corticosteroids with aldesleukin.
Food Interactions Not Available

Targets


Interleukin-2 receptor subunit beta
Name Interleukin-2 receptor subunit beta
Gene Name IL2RB
Pharmacological action yes
Actions agonist,modulator
References
  • Stauber DJ, Debler EW, Horton PA, Smith KA, Wilson IA: Crystal structure of the IL-2 signaling complex: paradigm for a heterotrimeric cytokine receptor. Proc Natl Acad Sci U S A. 2006 Feb 21;103(8):2788-93. Epub 2006 Feb 13. - Pubmed
  • Steppan S, Eckart MR, Bajsarowicz K, Sternberg LR, Greve JM, Cassell DJ: Reduced secondary cytokine induction by BAY 50-4798, a high-affinity receptor-specific interleukin-2 analog. J Interferon Cytokine Res. 2006 Mar;26(3):171-8. - Pubmed
  • Cornish GH, Sinclair LV, Cantrell DA: Differential regulation of T-cell growth by IL-2 and IL-15. Blood. 2006 Jul 15;108(2):600-8. Epub 2006 Mar 28. - Pubmed
  • Lee KD, Chen HW, Chen CC, Shih YC, Liu HK, Cheng ML: Construction and characterization of a novel fusion protein consisting of anti-CD3 antibody fused to recombinant interleukin-2. Oncol Rep. 2006 May;15(5):1211-6. - Pubmed
  • Maclennan C, Hutchinson P, Holdsworth S, Bardin PG, Freezer NJ: Airway inflammation in asymptomatic children with episodic wheeze. Pediatr Pulmonol. 2006 Jun;41(6):577-83. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 0.9573
Interleukin-2 receptor alpha chain
Name Interleukin-2 receptor alpha chain
Gene Name IL2RA
Pharmacological action yes
Actions agonist,modulator
References
  • Waldmann TA: Anti-Tac (daclizumab, Zenapax) in the treatment of leukemia, autoimmune diseases, and in the prevention of allograft rejection: a 25-year personal odyssey. J Clin Immunol. 2007 Jan;27(1):1-18. Epub 2007 Jan 11. - Pubmed
  • Recchia F, Cesta A, Rea S: Low dose interleukin-2 and 13-cis-retinoic acid as maintenance therapy in patients with solid tumors responsive to chemotherapy. J Exp Clin Cancer Res. 2003 Dec;22(4 Suppl):135-43. - Pubmed
  • Waldmann TA: Daclizumab (anti-Tac, Zenapax) in the treatment of leukemia/lymphoma. Oncogene. 2007 May 28;26(25):3699-703. - Pubmed
  • Vlad G, Ho EK, Vasilescu ER, Fan J, Liu Z, Cai JW, Jin Z, Burke E, Deng M, Cadeiras M, Cortesini R, Itescu S, Marboe C, Mancini D, Suciu-Foca N: Anti-CD25 treatment and FOXP3-positive regulatory T cells in heart transplantation. Transpl Immunol. 2007 Jul;18(1):13-21. Epub 2007 Apr 2. - Pubmed
  • Liu BY, Zhu P, Luo HB, Fu N: [Screening of short peptides binding to cell surface interleukin-2 receptor alpha chain] Nan Fang Yi Ke Da Xue Xue Bao. 2006 Jul;26(7):971-4. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
  • Ouyang Y, Kaminski NE: Phospholipase A2 inhibitors p-bromophenacyl bromide and arachidonyl trifluoromethyl ketone suppressed interleukin-2 (IL-2) expression in murine primary splenocytes. Arch Toxicol. 1999 Feb;73(1):1-6. - Pubmed
DTHybrid score 0.9576
Cytokine receptor common gamma chain
Name Cytokine receptor common gamma chain
Gene Name IL2RG
Pharmacological action yes
Actions agonist
References
  • Stauber DJ, Debler EW, Horton PA, Smith KA, Wilson IA: Crystal structure of the IL-2 signaling complex: paradigm for a heterotrimeric cytokine receptor. Proc Natl Acad Sci U S A. 2006 Feb 21;103(8):2788-93. Epub 2006 Feb 13. - Pubmed
  • Shibata F, Toma T, Wada T, Inoue M, Tone Y, Ohta K, Kasahara Y, Sano F, Kimura M, Ikeno M, Koizumi S, Yachie A: Skin infiltration of CD56(bright) CD16(-) natural killer cells in a case of X-SCID with Omenn syndrome-like manifestations. Eur J Haematol. 2007 Jul;79(1):81-5. - Pubmed
  • Fonseca SG, Reis MM, Coelho V, Nogueira LG, Monteiro SM, Mairena EC, Bacal F, Bocchi E, Guilherme L, Zheng XX, Liew FY, Higuchi ML, Kalil J, Cunha-Neto E: Locally produced survival cytokines IL-15 and IL-7 may be associated to the predominance of CD8+ T cells at heart lesions of human chronic Chagas disease cardiomyopathy. Scand J Immunol. 2007 Aug-Sep;66(2-3):362-71. - Pubmed
  • Blank RB, Lamb EW, Tocheva AS, Crow ET, Lim KC, McKerrow JH, Davies SJ: The common gamma chain cytokines interleukin (IL)-2 and IL-7 indirectly modulate blood fluke development via effects on CD4+ T cells. J Infect Dis. 2006 Dec 1;194(11):1609-16. Epub 2006 Oct 23. - Pubmed
  • Smyth CM, Ginn SL, Deakin CT, Logan GJ, Alexander IE: Limiting {gamma}c expression differentially affects signaling via the interleukin (IL)-7 and IL-15 receptors. Blood. 2007 Jul 1;110(1):91-8. Epub 2007 Mar 15. - Pubmed
DTHybrid score 0.9583

Enzymes


Prostaglandin G/H synthase 2
Name Prostaglandin G/H synthase 2
Gene Name PTGS2
Actions inducer
References
  • Pyeon D, Diaz FJ, Splitter GA: Prostaglandin E(2) increases bovine leukemia virus tax and pol mRNA levels via cyclooxygenase 2: regulation by interleukin-2, interleukin-10, and bovine leukemia virus. J Virol. 2000 Jun;74(12):5740-5. - Pubmed
  • Hamada T, Tsuchihashi S, Avanesyan A, Duarte S, Moore C, Busuttil RW, Coito AJ: Cyclooxygenase-2 deficiency enhances Th2 immune responses and impairs neutrophil recruitment in hepatic ischemia/reperfusion injury. J Immunol. 2008 Feb 1;180(3):1843-53. - Pubmed
DTHybrid score 0.5164
Cytosolic phospholipase A2
Name Cytosolic phospholipase A2
Gene Name PLA2G4A
Actions inducer
References
  • Wolbink GJ, Schalkwijk C, Baars JW, Wagstaff J, van den Bosch H, Hack CE: Therapy with interleukin-2 induces the systemic release of phospholipase-A2. Cancer Immunol Immunother. 1995 Nov;41(5):287-92. - Pubmed
DTHybrid score 0.5509
Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions inhibitor
References
  • Elkahwaji J, Robin MA, Berson A, Tinel M, Letteron P, Labbe G, Beaune P, Elias D, Rougier P, Escudier B, Duvillard P, Pessayre D: Decrease in hepatic cytochrome P450 after interleukin-2 immunotherapy. Biochem Pharmacol. 1999 Apr 15;57(8):951-4. - Pubmed
  • Sunman JA, Hawke RL, LeCluyse EL, Kashuba AD: Kupffer cell-mediated IL-2 suppression of CYP3A activity in human hepatocytes. Drug Metab Dispos. 2004 Mar;32(3):359-63. - Pubmed
DTHybrid score 0.4394
Xanthine dehydrogenase/oxidase
Name Xanthine dehydrogenase/oxidase
Gene Name XDH
Actions inducer
References
  • Faggioni R, Allavena P, Cantoni L, Carelli M, Demitri MT, Delgado R, Gatti S, Gnocchi P, Isetta AM, Paganin C, et al.: Mechanisms of interleukin-2-induced hydrothoraxy in mice: protective effect of endotoxin tolerance and dexamethasone and possible role of reactive oxygen intermediates. J Immunother Emphasis Tumor Immunol. 1994 Apr;15(3):194-201. - Pubmed
DTHybrid score 0.5606
Cytochrome P450 2E1
Name Cytochrome P450 2E1
Gene Name CYP2E1
Actions inhibitor
References
  • Elkahwaji J, Robin MA, Berson A, Tinel M, Letteron P, Labbe G, Beaune P, Elias D, Rougier P, Escudier B, Duvillard P, Pessayre D: Decrease in hepatic cytochrome P450 after interleukin-2 immunotherapy. Biochem Pharmacol. 1999 Apr 15;57(8):951-4. - Pubmed
DTHybrid score 0.3127

Predictions


Id Partner name Gene Name Score
20 Prostaglandin G/H synthase 1 PTGS1 0.2001
4757 Cytochrome P450 2C9 CYP2C9 0.1328
4200 Cytochrome P450 1A2 CYP1A2 0.1188
4119 Cytochrome P450 2D6 CYP2D6 0.1082
3817 Complement C1q subcomponent subunit C C1QC 0.1032
3816 Complement C1q subcomponent subunit B C1QB 0.1031
3815 Complement C1q subcomponent subunit A C1QA 0.1031
1102 Low affinity immunoglobulin gamma Fc region receptor III-B FCGR3B 0.102
3818 Low affinity immunoglobulin gamma Fc region receptor III-A FCGR3A 0.102
3819 Low affinity immunoglobulin gamma Fc region receptor II-a FCGR2A 0.102
3821 Low affinity immunoglobulin gamma Fc region receptor II-c FCGR2C 0.102
3814 Complement C1r subcomponent C1R 0.1019
3820 Low affinity immunoglobulin gamma Fc region receptor II-b FCGR2B 0.101
784 High affinity immunoglobulin gamma Fc receptor I FCGR1A 0.0999
1588 Multidrug resistance protein 1 ABCB1 0.0953
6016 Cytochrome P450 2C19 CYP2C19 0.0948
4118 Cytochrome P450 3A5 CYP3A5 0.0852
4924 Cytochrome P450 2C8 CYP2C8 0.081
1193 Proteinase-activated receptor 1 F2R 0.0777
1729 Solute carrier family 22 member 6 SLC22A6 0.0761
6020 Aldehyde oxidase AOX1 0.0696
1757 Myeloperoxidase MPO 0.0624
6030 Cytochrome P450 2B6 CYP2B6 0.0602
871 Glucocorticoid receptor NR3C1 0.0569
2782 Complement C1s subcomponent C1S 0.0557
232 Corticosteroid-binding globulin SERPINA6 0.0552
6107 Cytochrome P450 3A7 CYP3A7 0.0541
6024 Cytochrome P450 1A1 CYP1A1 0.0522
587 Serum albumin ALB 0.0499
5718 Cytochrome P450 2A6 CYP2A6 0.0454
234 Plasminogen PLG 0.0448
1898 Cytochrome P450 1B1 CYP1B1 0.0413
6142 Solute carrier family 22 member 8 SLC22A8 0.0356
862 Multidrug resistance-associated protein 1 ABCC1 0.0348
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0341
3811 Cytochrome P450 19A1 CYP19A1 0.0332
588 Chromodomain-helicase-DNA-binding protein 1 CHD1 0.033
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0319
6116 Gastric triacylglycerol lipase LIPF 0.0314
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0305
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0296
817 DNA topoisomerase 2-alpha TOP2A 0.0292
1295 Fatty acid synthase FASN 0.0291
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0288
754 Pancreatic triacylglycerol lipase PNLIP 0.028
4132 Chloride channel protein ClC-Ka CLCNKA 0.0276
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0252
3923 Cholinesterase BCHE 0.025
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0238
2164 Multidrug resistance-associated protein 4 ABCC4 0.0234
6144 Solute carrier family 22 member 2 SLC22A2 0.0225
6143 Solute carrier family 22 member 7 SLC22A7 0.0225
614 Progesterone receptor PGR 0.0218
1770 Phospholipase C PLCL1 0.0215
2841 Phospholipase C plc 0.0215
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0215
275 Arachidonate 5-lipoxygenase ALOX5 0.0213
556 Alpha-1A adrenergic receptor ADRA1A 0.0209
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0203
492 Histamine H1 receptor HRH1 0.0201
4165 P2Y purinoceptor 2 P2RY2 0.0198
737 Mineralocorticoid receptor NR3C2 0.0197
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.0194
814 Ryanodine receptor 1 RYR1 0.0191
896 Glutathione S-transferase Mu 1 GSTM1 0.0188
1159 Interleukin-6 IL6 0.0185
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0185
430 Follicle-stimulating hormone receptor FSHR 0.0179
1656 CYP2B protein CYP2B 0.0174
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0174
1405 Thiopurine S-methyltransferase TPMT 0.0172
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0172
6500 Phospholipase A2 PLA2G1B 0.0171
87 Hypoxanthine-guanine phosphoribosyltransferase HPRT1 0.0171
489 Monocarboxylate transporter 2 SLC16A7 0.0169
63 Malate dehydrogenase mdh 0.0165
2329 Malate dehydrogenase mdh 0.0165
3445 Malate dehydrogenase mdh 0.0165
4420 Malate dehydrogenase mdh 0.0165
4438 Malate dehydrogenase mdh 0.0165
831 D(2) dopamine receptor DRD2 0.0165
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0162
777 Tumor necrosis factor TNF 0.0161
2654 Complement control protein C3L 0.0161
738 Monocarboxylate transporter 1 SLC16A1 0.016
260 Cytochrome P450 51 ERG11 0.0158
761 Cytochrome P450 51 ERG11 0.0158
3163 Cytochrome P450 51 cyp51 0.0158
327 Glutathione reductase gor 0.0156
5110 Glutathione reductase GR2 0.0156
824 Sodium-dependent serotonin transporter SLC6A4 0.0155
4203 Histamine N-methyltransferase HNMT 0.0153
6106 Cytochrome P450 2C18 CYP2C18 0.0152
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0149
893 [Citrate [pro-3S]-lyase] ligase citC 0.0149
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0149
6145 Solute carrier family 22 member 1 SLC22A1 0.0149
833 Organic cation/carnitine transporter 1 SLC22A4 0.0148
1024 Solute carrier family 22 member 11 SLC22A11 0.0148
776 Bile salt export pump ABCB11 0.0147
5455 Arylsulfatase A ARSA 0.0146
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0145
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0145
2981 Phospholipase A2, membrane associated PLA2G2A 0.0143
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0143
6220 Aryl hydrocarbon receptor AHR 0.0141
3932 Glutathione S-transferase A2 GSTA2 0.0139
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0139
6137 Multidrug resistance-associated protein 6 ABCC6 0.0137
502 5-hydroxytryptamine 2A receptor HTR2A 0.0135
672 Prostaglandin F2-alpha receptor PTGFR 0.0135
136 Estrogen receptor ESR1 0.0133
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0132
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0124
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0124
468 Cytochrome P450 4A11 CYP4A11 0.0123
373 Transthyretin TTR 0.0122
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0122
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0121
465 Calmodulin CALM1 0.0121
442 Envelope glycoprotein gp41 0.012
4859 Envelope glycoprotein env 0.012
908 Glutathione S-transferase theta-1 GSTT1 0.012
6136 Multidrug resistance-associated protein 5 ABCC5 0.0116
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0116
54 Prothrombin F2 0.0116
853 Farnesyl pyrophosphate synthetase FDPS 0.0113
3312 Fatty acid-binding protein, brain FABP7 0.0113
904 Glutathione S-transferase P GSTP1 0.0112
318 Alpha-2A adrenergic receptor ADRA2A 0.0111
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0111
303 Diamine acetyltransferase 2 SAT2 0.0109
623 Spermine oxidase SMOX 0.0109
1317 Spermine synthase SMS 0.0109
320 5-hydroxytryptamine 1A receptor HTR1A 0.0109
4031 Glutathione S-transferase A1 GSTA1 0.0108
6163 Copper-transporting ATPase 2 ATP7B 0.0105
6165 Copper-transporting ATPase 1 ATP7A 0.0105
6146 High affinity copper uptake protein 1 SLC31A1 0.0104
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0104
6148 Multidrug resistance-associated protein 7 ABCC10 0.0103
23 D(1A) dopamine receptor DRD1 0.0102
123 Diamine acetyltransferase 1 SAT1 0.01
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0097
146 Androgen receptor AR 0.0097
185 Vasopressin V1a receptor AVPR1A 0.0096
731 HIV-1 protease HIV-1 protease 0.0095
1439 Lactotransferrin LTF 0.0095
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0095
322 Vasopressin V2 receptor AVPR2 0.0094
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0094
4604 Liver carboxylesterase 1 CES1 0.0093
847 Mu-type opioid receptor OPRM1 0.0093
118 Organic cation/carnitine transporter 2 SLC22A5 0.0093
341 5-hydroxytryptamine 3 receptor HTR3A 0.0093
6102 Arylamine N-acetyltransferase 2 NAT2 0.0092
6859 Protein S100-A4 S100A4 0.0091
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0089
6031 Cytochrome P450 3A43 CYP3A43 0.0087
6168 Solute carrier family 22 member 16 SLC22A16 0.0087
590 5-hydroxytryptamine 2C receptor HTR2C 0.0087
782 ADP/ATP translocase 2 SLC25A5 0.0086
688 ADP/ATP translocase 3 SLC25A6 0.0086
632 Alpha-1B adrenergic receptor ADRA1B 0.0086
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0085
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0084
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0084
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0083
16 Adenosine A1 receptor ADORA1 0.0082
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0082
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.0082
766 Beta-2 adrenergic receptor ADRB2 0.0082
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0081
705 Glutamate receptor 1 GRIA1 0.008
274 Muscarinic acetylcholine receptor M5 CHRM5 0.008
4120 NADPH--cytochrome P450 reductase POR 0.0079
61 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0079
2644 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0079
2710 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0079
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0078
449 Ornithine decarboxylase ODC1 0.0078
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0078
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0078
482 Glycine receptor subunit alpha-1 GLRA1 0.0077
703 NADPH azoreductase azr 0.0076
4221 Vascular endothelial growth factor VEGF 0.0075
5816 Cadherin-5 CDH5 0.0075
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0075
613 Atrial natriuretic peptide receptor A NPR1 0.0074
467 Delta-type opioid receptor OPRD1 0.0073
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0073
3941 Amine oxidase [flavin-containing] A MAOA 0.0073
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0073
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0073
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0072
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0072
6043 Putative G-protein coupled receptor 44 GPR44 0.0072
789 Alpha-1D adrenergic receptor ADRA1D 0.0071
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0071
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0071
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0071
850 Vasopressin V1b receptor AVPR1B 0.007
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0069
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0069
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0069
6171 Solute carrier family 28 member 3 SLC28A3 0.0068
537 ATP synthase delta chain, mitochondrial ATP5D 0.0068
193 Beta-1 adrenergic receptor ADRB1 0.0068
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0068
811 Translocator protein TSPO 0.0068
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0068
4192 DNA topoisomerase 2-beta TOP2B 0.0068
1374 Natriuretic peptides B NPPB 0.0068
1827 Gap junction alpha-1 protein GJA1 0.0068
1908 Vascular cell adhesion protein 1 VCAM1 0.0068
885 5-hydroxytryptamine 1B receptor HTR1B 0.0068
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0067
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0067
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0067
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0067
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0067
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0066
638 D(3) dopamine receptor DRD3 0.0066
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0066
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0066
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0066
713 Sodium-dependent dopamine transporter SLC6A3 0.0065
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0065
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0065
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0064
661 ADP/ATP translocase 1 SLC25A4 0.0064
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0064
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0064
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0064
400 Coagulation factor IX F9 0.0063
5461 Coagulation factor IX F9 0.0063
291 Nitric-oxide synthase, endothelial NOS3 0.0063
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0063
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0063
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0063
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0063
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0063
636 Mitochondrial carnitine/acylcarnitine carrier protein SLC25A20 0.0062
109 Mitochondrial carnitine/acylcarnitine carrier protein CACL SLC25A29 0.0062
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0062
6147 Solute carrier family 22 member 3 SLC22A3 0.0062
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0061
6012 Tryptophan 2,3-dioxygenase TDO2 0.0061
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.006
134 Tryptophan 5-hydroxylase 1 TPH1 0.006
1178 Adenosine A2a receptor ADORA2A 0.006
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0059
4148 Serine/threonine-protein kinase mTOR MTOR 0.0059
696 Kappa-type opioid receptor OPRK1 0.0059
818 50S ribosomal protein L10 rplJ 0.0058
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0058
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0058
604 Vitamin K-dependent protein Z PROZ 0.0058
183 Vascular endothelial growth factor A VEGFA 0.0058
378 Alpha-2C adrenergic receptor ADRA2C 0.0058
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0057
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0057
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0057
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0056
6141 Sodium/bile acid cotransporter SLC10A1 0.0056
3939 Amine oxidase [flavin-containing] B MAOB 0.0056
1648 Elastin ELN 0.0056
725 5-hydroxytryptamine 1D receptor HTR1D 0.0055
29 Tubulin beta-1 chain TUBB1 0.0054
551 Carnitine O-acetyltransferase CRAT 0.0054
629 Alpha-2B adrenergic receptor ADRA2B 0.0054
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0054
676 Tyrosine 3-monooxygenase TH 0.0054
412 Peroxisomal carnitine O-octanoyltransferase CROT 0.0054
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0053
422 Vitamin K-dependent protein C PROC 0.0053
1245 Vitamin K-dependent protein S PROS1 0.0053
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0053
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0052
828 Phenylalanine-4-hydroxylase PAH 0.0052
3109 Phenylalanine-4-hydroxylase phhA 0.0052
592 Carbonic anhydrase 4 CA4 0.0052
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0051
444 Alcohol dehydrogenase 1B ADH1B 0.0051
122 P2Y purinoceptor 12 P2RY12 0.005
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.005
1010 Cytochrome P450 51A1 CYP51A1 0.005
80 Peroxisome proliferator-activated receptor alpha PPARA 0.005
251 Alcohol dehydrogenase 1A ADH1A 0.0049
823 Fibroblast growth factor receptor 2 FGFR2 0.0048
3917 Methylenetetrahydrofolate reductase MTHFR 0.0048
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0048
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0048
161 Tubulin beta chain TUBB 0.0048
312 Tubulin beta chain TUB2 0.0048
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0048
432 D(4) dopamine receptor DRD4 0.0047
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0047
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0047
2230 Catalase CAT 0.0047
3249 Catalase katA 0.0047
3625 Catalase katA 0.0047
4539 Catalase katA 0.0047
4941 Catalase katB 0.0047
4122 Histone deacetylase 2 HDAC2 0.0046
3601 Dihydropteroate synthase 1 folP1 0.0046
3807 Dihydropteroate synthase 1 folP1 0.0046
3808 Dihydropteroate synthase 2 folP2 0.0046
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0046
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0045
295 Carbonic anhydrase 1 CA1 0.0045
790 DNA polymerase subunit alpha B POLA2 0.0045
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0045
2178 Metabotropic glutamate receptor 5 GRM5 0.0045
130 Prostacyclin synthase PTGIS 0.0044
798 Osteocalcin BGLAP 0.0044
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0044
4116 Dihydropteroate synthetase Not Available 0.0044
6014 Cytochrome P450 2A13 CYP2A13 0.0043
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0042
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0042
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0042
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0041
716 5-hydroxytryptamine 7 receptor HTR7 0.0041
239 Coagulation factor X F10 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
1650 Heme carrier protein 1 SLC46A1 0.0041
436 5-hydroxytryptamine 2B receptor HTR2B 0.004
952 Dipeptidyl peptidase 4 DPP4 0.004
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.004
1050 Bile salt sulfotransferase SULT2A1 0.004
369 Coagulation factor VII F7 0.004
94 5-hydroxytryptamine 4 receptor HTR4 0.004
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0039
357 Carbonic anhydrase 2 CA2 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0038
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0038
891 Dihydropteroate synthase folP 0.0038
5359 Dihydropteroate synthase folP 0.0038
7175 Dihydropteroate synthase sulI 0.0038
517 Alcohol dehydrogenase 1C ADH1C 0.0038
1192 Sulfotransferase 1A1 SULT1A1 0.0038
1483 Membrane copper amine oxidase AOC3 0.0038
153 Dopamine beta-hydroxylase DBH 0.0037
869 Estrogen receptor beta ESR2 0.0037
1789 Lymphotoxin-alpha LTA 0.0037
1269 Tumor necrosis factor receptor superfamily member 1B TNFRSF1B 0.0037
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0037
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0037
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0037
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0037
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0037
390 Adenosine A3 receptor ADORA3 0.0037
6126 Carbonic anhydrase 7 CA7 0.0036
473 L-lactate dehydrogenase A chain LDHA 0.0036
6182 Cytochrome P450 2J2 CYP2J2 0.0036
68 Cannabinoid receptor 1 CNR1 0.0036
3404 Exotoxin A eta 0.0036
856 Vitamin D3 receptor VDR 0.0035
284 DNA-directed RNA polymerase beta chain rpoB 0.0035
5773 DNA-directed RNA polymerase beta chain rpoB 0.0035
4237 50S ribosomal protein L22 rplV 0.0035
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0035
2236 Casein kinase II subunit alpha CSNK2A1 0.0035
939 50S ribosomal protein L3 rplC 0.0035
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0035
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0034
6138 Multidrug resistance protein 3 ABCB4 0.0034
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0034
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0033
474 Acetylcholinesterase ACHE 0.0033
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0033
1714 Mitogen-activated protein kinase 3 MAPK3 0.0033
7 Nitric oxide synthase, inducible NOS2 0.0033
459 Retinoic acid receptor RXR-alpha RXRA 0.0033
3810 Catechol O-methyltransferase COMT 0.0033
759 Free fatty acid receptor 1 FFAR1 0.0032
1818 Long-chain-fatty-acid--CoA ligase 3 ACSL3 0.0032
6033 High affinity interleukin-8 receptor A CXCR1 0.0032
6766 O-GlcNAcase BT_4395 BT_4395 0.0031
3090 Chitosanase csn 0.0031
4149 Nuclear factor NF-kappa-B p100 subunit NFKB2 0.0031
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0031
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0031
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0031
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0031
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0031
921 Glutamate receptor 2 GRIA2 0.0031
2578 Tubulin beta-3 chain TUBB3 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.003
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.003
365 Dihydrofolate reductase DHFR 0.003
2381 Dihydrofolate reductase DFR1 0.003
2833 Dihydrofolate reductase Not Available 0.003
2931 Dihydrofolate reductase folA 0.003
3544 Dihydrofolate reductase folA 0.003
3682 Dihydrofolate reductase folA 0.003
6642 Dihydrofolate reductase folA 0.003
6756 Dihydrofolate reductase dfrA 0.003
518 Peroxidase/catalase T katG 0.003
1256 5-hydroxytryptamine 6 receptor HTR6 0.003
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0029
76 Nitric-oxide synthase, brain NOS1 0.0029
2298 Cytochrome P450-cam camC 0.0029
756 Sex hormone-binding globulin SHBG 0.0029
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0029
2290 ADP-ribosyl cyclase 2 BST1 0.0028
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0028
6149 Solute carrier family 22 member 10 SLC22A10 0.0028
1253 Interferon gamma IFNG 0.0028
330 Spermidine synthase SRM 0.0028
3038 Spermidine synthase speE 0.0028
1053 BC269730_2 FADS1 0.0028
1395 Sodium/calcium exchanger 1 SLC8A1 0.0028
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0027
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0027
3937 Fatty-acid amide hydrolase FAAH 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
1275 Estrogen sulfotransferase SULT1E1 0.0027
163 D(1B) dopamine receptor DRD5 0.0027
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0027
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0026
1558 Transient receptor potential cation channel subfamily V member 1 TRPV1 0.0026
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0026
663 Solute carrier family 12 member 4 SLC12A4 0.0026
33 Cystine/glutamate transporter SLC7A11 0.0026
53 Solute carrier family 12 member 5 SLC12A5 0.0026
49 Endothelin B receptor EDNRB 0.0026
358 Cystathionine beta-synthase CBS 0.0026
407 Vascular endothelial growth factor receptor 2 KDR 0.0025
563 Thyroid peroxidase TPO 0.0025
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0025
380 Cytochrome P450 17A1 CYP17A1 0.0025
768 FK506-binding protein 1A FKBP1A 0.0025
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0025
310 Solute carrier family 12 member 2 SLC12A2 0.0024
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0024
578 Endothelin-1 receptor EDNRA 0.0024
334 S-adenosylmethionine synthetase isoform type-2 MAT2A 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
124 Histamine H2 receptor HRH2 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
822 Aldose reductase AKR1B1 0.0023
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0023
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.0023
844 Epidermal growth factor receptor EGFR 0.0023
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0023
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0023
70 Type-1 angiotensin II receptor AGTR1 0.0023
605 Fumarate reductase flavoprotein subunit frdA 0.0022
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0022
3673 Fumarate reductase flavoprotein subunit fccA 0.0022
4912 Fumarate reductase flavoprotein subunit ifcA 0.0022
6549 Fumarate reductase flavoprotein subunit frdA 0.0022
504 Mast/stem cell growth factor receptor KIT 0.0022
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0022
113 S-adenosylmethionine decarboxylase proenzyme AMD1 0.0022
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0022
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0022
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0022
411 Glycine N-methyltransferase GNMT 0.0022
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0022
65 Matrix metalloproteinase-9 Not Available 0.0021
2449 Tubulin alpha-3 chain TUBA1A 0.0021
298 Renin REN 0.0021
6506 Stathmin-4 STMN4 0.0021
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0021
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0021
2539 Tubulin alpha-1 chain TUBA4A 0.0021
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0021
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.002
2268 Cholesterol oxidase choB 0.002
2822 Cholesterol oxidase choA 0.002
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.002
6432 Transporter snf 0.002
633 Penicillin-binding proteins 1A/1B pbpA 0.0019
3913 Glutamic acid decarboxylase GAD65 0.0019
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0019
718 Folate receptor gamma FOLR3 0.0019
299 Folate receptor beta FOLR2 0.0019
2499 Tubulin beta-2C chain TUBB2C 0.0019
804 Mitochondrial folate transporter/carrier SLC25A32 0.0019
233 Potassium channel subfamily K member 2 KCNK2 0.0019
6131 Carbonic anhydrase 14 CA14 0.0019
3809 Estrogen-related receptor gamma ESRRG 0.0019
558 Solute carrier family 12 member 1 SLC12A1 0.0019
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0019
477 DNA topoisomerase 4 subunit A parC 0.0019
886 DNA topoisomerase 4 subunit A parC 0.0019
6226 DNA topoisomerase 4 subunit A parC 0.0019
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0019
404 DNA gyrase subunit A gyrA 0.0018
6224 DNA gyrase subunit A gyrA 0.0018
5998 Toll-like receptor 8 TLR8 0.0018
26 Vascular endothelial growth factor receptor 3 FLT4 0.0018
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0018
4238 50S ribosomal protein L4 rplD 0.0018
5578 50S ribosomal protein L4 rplD 0.0018
6173 50S ribosomal protein L4 rplD 0.0018
6219 50S ribosomal protein L4 rplD 0.0018
712 Tubulin alpha chain TUB1 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
565 Extracellular calcium-sensing receptor CASR 0.0018
319 Opioid receptor, sigma 1 OPRS1 0.0018
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0018
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0018
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0018
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0018
683 Potassium transporter GK0582 0.0018
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0018
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0018
6122 Carbonic anhydrase 3 CA3 0.0018
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0018
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
273 Apoptosis regulator Bcl-2 BCL2 0.0017
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0017
32 Vascular endothelial growth factor receptor 1 FLT1 0.0017
543 Penicillin-binding protein 1B mrcB 0.0017
6186 Penicillin-binding protein 1B ponB 0.0017
6822 Penicillin-binding protein 1b pbp1b 0.0017
6844 Penicillin-binding protein 1b pbp1b 0.0017
976 Platelet glycoprotein IX GP9 0.0017
159 Penicillin-binding protein 2B penA 0.0017
6121 Penicillin-binding protein 2B penA 0.0017
178 NADH-cytochrome b5 reductase 3 CYB5R3 0.0017
812 Dihydrolipoyl dehydrogenase, mitochondrial DLD 0.0017
293 Gamma-glutamyl hydrolase GGH 0.0017
6085 Fatty acid-binding protein, intestinal FABP2 0.0017
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0016
2021 Thrombomodulin THBD 0.0016
228 Beta platelet-derived growth factor receptor PDGFRB 0.0016
735 Alanine aminotransferase 1 GPT 0.0016
3904 Alanine aminotransferase 2 GPT2 0.0016
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0016
1852 Microtubule-associated protein 2 MAP2 0.0016
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0016
173 Toll-like receptor 7 TLR7 0.0016
528 5-hydroxytryptamine 1E receptor HTR1E 0.0015
3233 Bile acid receptor NR1H4 0.0015
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0015
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0015
174 Sigma 1-type opioid receptor SIGMAR1 0.0015
427 Substance-P receptor TACR1 0.0015
1629 Transcription factor AP-1 JUN 0.0015
4311 tRNA TRDMT1 0.0015
4325 tRNA trmD 0.0015
4328 tRNA trmD 0.0015
3102 Flavohemoprotein hmp 0.0015
4969 Flavohemoprotein hmp 0.0015
839 Short-chain specific acyl-CoA dehydrogenase, mitochondrial ACADS 0.0015
581 Cytochrome P450 2R1 CYP2R1 0.0015
634 Squalene monooxygenase SQLE 0.0014
7196 Squalene monooxygenase ERG1 0.0014
1541 Metalloproteinase mmp20 0.0014
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0014
820 Glycine receptor subunit alpha-2 GLRA2 0.0014
268 Adenosine A2b receptor ADORA2B 0.0014
469 Annexin A1 ANXA1 0.0014
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0014
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0013
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0013
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0013
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0013
1353 DNA topoisomerase 1 TOP1 0.0013
3552 DNA topoisomerase 1 topA 0.0013
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0013
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0013
4486 Phenol 2-hydroxylase component B pheA2 0.0013
4439 Ferredoxin reductase bphA4 0.0013
4477 Dihydrolipoyl dehydrogenase lpdV 0.0013
5077 Dihydrolipoyl dehydrogenase Not Available 0.0013
5117 Dihydrolipoyl dehydrogenase lpd 0.0013
84 Nuclear receptor 0B1 NR0B1 0.0013
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0012
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0012
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0012
1618 High affinity nerve growth factor receptor NTRK1 0.0012
780 Retinoic acid receptor RXR-gamma RXRG 0.0012
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
6042 Prostaglandin reductase 2 PTGR2 0.0012
5078 Amine oxidase, flavin-containing PSPTO1126 0.0012
5122 Mersacidin decarboxylase mrsD 0.0012
526 Thioredoxin reductase trxB 0.0012
3767 Thioredoxin reductase trxB 0.0012
5112 Benzoate 1,2-dioxygenase electron transfer component benC 0.0012
3763 5,10-methylenetetrahydrofolate reductase metF 0.0012
3918 5,10-methylenetetrahydrofolate reductase MTHFR 0.0012
5094 5,10-methylenetetrahydrofolate reductase metF 0.0012
5097 PROBABLE DIHYDROLIPOAMIDE DEHYDROGENASE LPDA lpdA 0.0012
5102 4-cresol dehydrogenase [hydroxylating] flavoprotein subunit pchF 0.0012
5115 FkbI fkbI 0.0012
3133 UDP-galactopyranose mutase glf 0.0012
5099 UDP-galactopyranose mutase glf 0.0012
5114 Putative acyl-CoA dehydrogenase TT_C0779 0.0012
5095 Putidaredoxin reductase camA 0.0012
5083 Cryptochrome DASH cry 0.0012
5100 Gamma-aminobutyrate metabolism dehydratase/isomerase abfD 0.0012
5107 Alkyl hydroperoxide reductase subunit F ahpF 0.0012
5118 Alkyl hydroperoxide reductase subunit F ahpF 0.0012
5081 L-aspartate oxidase nadB 0.0012
5111 Phenylacetone monooxygenase pamO 0.0012
1410 Oxidoreductase HSD17B6 0.0012
4725 Oxidoreductase Not Available 0.0012
5124 Oxidoreductase Not Available 0.0012
5109 Outer membrane protein p64k or PM-6 m-6 0.0012
1329 Apoptosis-inducing factor 1, mitochondrial AIFM1 0.0012
3221 Cytochrome c4 cc4 0.0012
85 Growth hormone receptor GHR 0.0012
2107 Microtubule-associated protein 1A MAP1A 0.0012
571 Melatonin receptor type 1A MTNR1A 0.0012
362 Melatonin receptor type 1B MTNR1B 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0012
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0012
1268 Neuropeptide S receptor NPSR1 0.0012
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0012
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0012
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0012
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0012
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0012
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0012
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0012
164 Histamine H4 receptor HRH4 0.0012
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0011
1792 Tissue-type plasminogen activator PLAT 0.0011
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0011
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0011
88 Retinoic acid receptor RXR-beta RXRB 0.0011
714 Glutathione reductase, mitochondrial GSR 0.0011
751 Potassium channel subfamily K member 6 KCNK6 0.0011
4440 NADH peroxidase npr 0.0011
5787 Angiopoietin-1 receptor TEK 0.0011
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0011
6073 Potassium channel subfamily K member 9 KCNK9 0.0011
6072 Potassium channel subfamily K member 3 KCNK3 0.0011
5072 N,N-dimethylglycine oxidase dmg 0.0011
5073 Ferredoxin--NADP reductase petH 0.0011
5076 Ferredoxin--NADP reductase fpr 0.0011
5119 Ferredoxin--NADP reductase petH 0.0011
5121 Ferredoxin--NADP reductase fpr 0.0011
1360 Sphingomyelin phosphodiesterase SMPD1 0.0011
5075 Sulfite reductase [NADPH] flavoprotein alpha-component cysJ 0.0011
3594 Deoxyribodipyrimidine photo-lyase phr 0.0011
5079 Deoxyribodipyrimidine photo-lyase phrB 0.0011
5080 Deoxyribodipyrimidine photo-lyase phr 0.0011
440 Isovaleryl-CoA dehydrogenase, mitochondrial IVD 0.0011
5003 Acyl-CoA dehydrogenase, short-chain specific Not Available 0.0011
2526 NADPH-ferredoxin reductase fprA fprA 0.0011
667 Acyl-CoA dehydrogenase family member 8, mitochondrial ACAD8 0.0011
5091 UDP-N-acetylenolpyruvoylglucosamine reductase murB 0.0011
5093 UDP-N-acetylenolpyruvoylglucosamine reductase murB 0.0011
3506 Glutaryl-CoA dehydrogenase, mitochondrial GCDH 0.0011
2470 Pyruvate oxidase pox5 0.0011
6639 Peroxisomal acyl-coenzyme A oxidase 1 ACOX1 0.0011
3247 2-oxopropyl-CoM reductase, carboxylating xecC 0.001
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.001
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
4228 Keratin, type II cytoskeletal 7 KRT7 0.001
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.001
3238 Multidrug resistance protein mexA mexA 0.001
3709 Glycerol uptake facilitator protein glpF 0.001
3116 Bacterioferritin bfr 0.001
4906 Bacterioferritin bfr 0.001
4965 Bacterioferritin bfr 0.001
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.001
3173 Enolase eno 0.001
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.001
3393 TGF-beta receptor type-2 TGFBR2 0.001
172 Potassium channel subfamily K member 1 KCNK1 0.001
1144 Hepatocyte growth factor receptor MET 0.001
3007 Carbonic anhydrase 12 CA12 0.001
4205 Carbonic anhydrase 9 CA9 0.001
126 D-lactate dehydrogenase dld 0.001
3545 D-lactate dehydrogenase Not Available 0.001
4510 D-lactate dehydrogenase ldhA 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.001
512 DNA-directed RNA polymerase alpha chain rpoA 0.001
5772 DNA-directed RNA polymerase alpha chain rpoA 0.001
5300 Antigen peptide transporter 1 TAP1 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
6824 Tyrosine-protein kinase Lyn LYN 0.001
3185 Medium-chain specific acyl-CoA dehydrogenase, mitochondrial ACADM 0.001
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.001
3254 Bifunctional protein putA [Includes: Proline dehydrogenase putA 0.001
2893 Glycine oxidase thiO 0.001
3957 Adenosine deaminase ADA 0.0009
997 Protein kinase C beta type PRKCB 0.0009
1313 Lactoylglutathione lyase GLO1 0.0009
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0009
4773 Deoxycytidine kinase DCK 0.0009
1517 Beta-3 adrenergic receptor ADRB3 0.0009
3573 2,4-dienoyl-CoA reductase [NADPH] fadH 0.0009
2567 Thymidylate synthase thyX thyX 0.0009
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0009
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0009
3086 Plasmepsin-2 Not Available 0.0009
2823 Trypanothione reductase TPR 0.0009
165 FL cytokine receptor FLT3 0.0009
1048 Protein S100-A13 S100A13 0.0009
2226 Protein S100-A12 S100A12 0.0009
2852 DNA mismatch repair protein mutL mutL 0.0009
2769 P-hydroxybenzoate hydroxylase pobA 0.0009
2809 P-hydroxybenzoate hydroxylase pobA 0.0009
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0009
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0009
2283 Steroid Delta-isomerase ksi 0.0009
2920 Steroid Delta-isomerase ksi 0.0009
3191 Histidinol dehydrogenase hisD 0.0009
1970 Protein kinase C alpha type PRKCA 0.0009
208 DNA-directed RNA polymerase beta' chain rpoC 0.0009
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0009
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0009
2132 Protein S100-B S100B 0.0009
2408 Tyrosine-protein kinase SYK SYK 0.0009
740 Argininosuccinate synthase ASS1 0.0009
865 Argininosuccinate synthase ASS1 0.0009
2680 Argininosuccinate synthase argG 0.0009
3194 Argininosuccinate synthase argG 0.0009
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0008
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0008
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0008
2380 Monomeric sarcosine oxidase soxA 0.0008
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0008
6459 Glycodelin PAEP 0.0008
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0008
4692 A/G-specific adenine glycosylase mutY 0.0008
2207 Rhodopsin RHO 0.0008
569 Retinal dehydrogenase 2 ALDH1A2 0.0008
6645 D-amino-acid oxidase DAO 0.0008
1867 Major prion protein PRNP 0.0008
2232 Interleukin-5 IL5 0.0008
1593 Mucin-2 MUC2 0.0008
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0008
611 Retinal dehydrogenase 1 ALDH1A1 0.0008
1025 Aquaporin-1 AQP1 0.0008
3856 Fibroblast growth factor receptor 3 FGFR3 0.0008
2091 Endoplasmin HSP90B1 0.0008
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0007
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0007
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0007
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0007
461 Glycine receptor subunit alpha-3 GLRA3 0.0007
6103 Arylamine N-acetyltransferase 1 NAT1 0.0007
2802 Endoglucanase G celCCG 0.0007
6316 ADP-ribosylation factor 1 ARF1 0.0007
2112 Toll-like receptor 9 TLR9 0.0007
6207 30S ribosomal protein S14 rpsN 0.0007
6209 30S ribosomal protein S19 rpsS 0.0007
6712 30S ribosomal protein S19 rpsS 0.0007
6726 30S ribosomal protein S19 rpsS 0.0007
645 Penicillin-binding protein 1A mrcA 0.0007
5805 Penicillin-binding protein 1A ponA 0.0007
6185 Penicillin-binding protein 1A mrcA 0.0007
6799 Penicillin-binding protein 1A pbpA 0.0007
810 Heme oxygenase 1 HMOX1 0.0007
3391 Heme oxygenase 1 pbsA1 0.0007
5924 Microtubule-associated protein 4 MAP4 0.0007
5923 Microtubule-associated protein tau MAPT 0.0007
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0007
24 Thymidylate synthase TMP1 0.0007
359 Thymidylate synthase TYMS 0.0007
2626 Thymidylate synthase thyA 0.0007
2729 Thymidylate synthase thyA 0.0007
5352 Thymidylate synthase THYA 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
1830 5'-nucleotidase NT5E 0.0007
816 Biliverdin reductase A BLVRA 0.0007
579 Alcohol dehydrogenase class 4 mu/sigma chain ADH7 0.0007
792 Aldehyde dehydrogenase, dimeric NADP-preferring ALDH3A1 0.0007
316 4-trimethylaminobutyraldehyde dehydrogenase ALDH9A1 0.0007
125 DNA polymerase beta POLB 0.0007
131 Synaptic vesicular amine transporter SLC18A2 0.0007
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0007
1123 Eosinophil cationic protein RNASE3 0.0007
2599 Tyrosine-protein kinase HCK HCK 0.0007
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0006
144 Hemoglobin subunit alpha HBA1 0.0006
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0006
106 Cannabinoid receptor 2 CNR2 0.0006
6174 50S ribosomal protein L32 rpmF 0.0006
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0006
30 NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial NDUFV3 0.0006
374 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 NDUFB1 0.0006
247 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 NDUFA1 0.0006
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0006
343 NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial NDUFC1 0.0006
190 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4 NDUFA4 0.0006
353 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 NDUFA4L2 0.0006
607 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 NDUFA2 0.0006
324 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 NDUFB4 0.0006
598 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 NDUFA11 0.0006
405 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 NDUFA8 0.0006
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0006
555 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial NDUFS4 0.0006
446 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 NDUFA7 0.0006
656 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 NDUFB9 0.0006
525 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 NDUFA5 0.0006
219 NADH-ubiquinone oxidoreductase chain 3 MT-ND3 0.0006
104 NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial NDUFS6 0.0006
236 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 NDUFA6 0.0006
417 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 NDUFB6 0.0006
475 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial NDUFB2 0.0006
582 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 NDUFA13 0.0006
829 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 NDUFA12 0.0006
755 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 NDUFA3 0.0006
487 Aldo-keto reductase family 1 member C4 AKR1C4 0.0006
313 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 NDUFB3 0.0006
384 NADH-ubiquinone oxidoreductase chain 6 MT-ND6 0.0006
300 NADH-ubiquinone oxidoreductase chain 4L MT-ND4L 0.0006
746 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial NDUFB8 0.0006
99 NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 NDUFS5 0.0006
270 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial NDUFB5 0.0006
644 Heme oxygenase 2 HMOX2 0.0006
4982 Heme oxygenase 2 pbsA2 0.0006
41 NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial NDUFS8 0.0006
335 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial NDUFA9 0.0006
568 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 NDUFB7 0.0006
616 Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial IDH3B 0.0006
152 NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial NDUFV2 0.0006
848 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial IDH3G 0.0006
145 Corticosteroid 11-beta-dehydrogenase isozyme 2 HSD11B2 0.0006
609 15-hydroxyprostaglandin dehydrogenase [NAD+] HPGD 0.0006
602 Acyl carrier protein, mitochondrial NDUFAB1 0.0006
539 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial NDUFV1 0.0006
272 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 NDUFB10 0.0006
372 Estradiol 17-beta-dehydrogenase 3 HSD17B3 0.0006
729 GDP-L-fucose synthetase TSTA3 0.0006
3463 GDP-L-fucose synthetase fcl 0.0006
167 L-lactate dehydrogenase C chain LDHC 0.0006
326 L-lactate dehydrogenase A-like 6A LDHAL6A 0.0006
141 3-hydroxyisobutyrate dehydrogenase, mitochondrial HIBADH 0.0006
180 D-3-phosphoglycerate dehydrogenase PHGDH 0.0006
3726 D-3-phosphoglycerate dehydrogenase serA 0.0006
4291 D-3-phosphoglycerate dehydrogenase serA 0.0006
206 3-keto-steroid reductase HSD17B7 0.0006
196 D-beta-hydroxybutyrate dehydrogenase, mitochondrial BDH1 0.0006
721 NADH-ubiquinone oxidoreductase chain 2 MT-ND2 0.0006
231 Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic GPD1 0.0006
91 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial NDUFA10 0.0006
14 Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial IDH3A 0.0006
50 Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating NSDHL 0.0006
112 L-lactate dehydrogenase A-like 6B LDHAL6B 0.0006
216 Aldehyde dehydrogenase 3B2 ALDH3B2 0.0006
637 NADH-ubiquinone oxidoreductase chain 5 MT-ND5 0.0006
9 Estradiol 17-beta-dehydrogenase 2 HSD17B2 0.0006
671 Pyruvate dehydrogenase E1 component alpha subunit, testis-specific form, mitochondrial PDHA2 0.0006
628 Pyruvate dehydrogenase E1 component alpha subunit, somatic form, mitochondrial PDHA1 0.0006
149 Alpha-aminoadipic semialdehyde dehydrogenase ALDH7A1 0.0006
608 NADH-ubiquinone oxidoreductase chain 4 MT-ND4 0.0006
496 Aldehyde dehydrogenase 3B1 ALDH3B1 0.0006
34 7-dehydrocholesterol reductase DHCR7 0.0006
662 Fatty aldehyde dehydrogenase ALDH3A2 0.0006
711 UDP-glucose 6-dehydrogenase UGDH 0.0006
3672 UDP-glucose 6-dehydrogenase hasB 0.0006
393 GDH/6PGL endoplasmic bifunctional protein [Includes: Glucose 1-dehydrogenase H6PD 0.0006
531 Aldehyde dehydrogenase X, mitochondrial ALDH1B1 0.0006
107 C-4 methylsterol oxidase SC4MOL 0.0006
258 Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial ALDH6A1 0.0006
271 Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial ALDH4A1 0.0006
288 Trifunctional enzyme subunit alpha, mitochondrial HADHA 0.0006
643 Peroxisomal bifunctional enzyme EHHADH 0.0006
548 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial NDUFS1 0.0006
1196 Complement decay-accelerating factor CD55 0.0006
3426 Glutamine synthetase glnA 0.0006
3987 Glutamine synthetase GLUL 0.0006
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0006
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0006
646 Malate dehydrogenase, cytoplasmic MDH1 0.0006
350 3-hydroxyacyl-CoA dehydrogenase type-2 HSD17B10 0.0006
454 Peroxisomal multifunctional enzyme type 2 HSD17B4 0.0006
328 Sorbitol dehydrogenase SORD 0.0006
396 Alcohol dehydrogenase 4 ADH4 0.0006
363 NADP-dependent malic enzyme, mitochondrial ME3 0.0006
597 Dihydropteridine reductase QDPR 0.0006
4943 Cytochrome c6 petJ 0.0006
4954 Soluble cytochrome b558 Not Available 0.0006
4984 Neuroglobin NGB 0.0006
4905 Cytochrome c2 Not Available 0.0006
4939 Cytochrome c2 cycA 0.0006
4964 Cytochrome c2 cycA 0.0006
4979 Cytochrome c2 cycA 0.0006
6673 Cytochrome c2 cycA 0.0006
4994 Hemoglobin-like protein HbO glbO 0.0006
4925 Cytochrome c-type protein SHP shp 0.0006
4934 Cytochrome c-551 nirM 0.0006
5218 Cytochrome c-551 nirM 0.0006
4998 Hemoglobin-like protein yjbI yjbI 0.0006
4947 Bacterial hemoglobin vhb 0.0006
4942 Diheme cytochrome c napB napB 0.0006
4910 Cytoglobin CYGB 0.0006
4936 Cytochrome c2 iso-2 Not Available 0.0006
4916 Cyanoglobin glbN 0.0006
4915 Cytochrome c-550 psbV 0.0006
4959 Cytochrome c-550 psbV 0.0006
5216 Cytochrome c-550 psbV 0.0006
4904 Cytochrome c family protein GSU1996 0.0006
4961 Hemophore HasA hasA 0.0006
4975 Cytochrome c-556 RPA3973 0.0006
4764 Cytochrome P450 165C4 CYP165C4 0.0006
5000 HemO hemO 0.0006
4971 Nonaheme cytochrome c hmcA 0.0006
4981 Iron-starvation protein PigA pigA 0.0006
4989 Cytochrome c551 peroxidase ccp 0.0006
5222 Cytochrome c551 peroxidase ccpA 0.0006
4976 Apocytochrome f petA 0.0006
6407 Apocytochrome f petA 0.0006
4907 Cytochrome c-L moxG 0.0006
6865 Cytochrome c-L moxG 0.0006
4909 CooA protein cooA 0.0006
4993 Hydroxylamine oxidoreductase hao1 0.0006
4935 Cytochrome c-554 cycA1 0.0006
4931 Cytochrome P450 167A1 CYP167A1 0.0006
4972 P450cin cinA 0.0006
4960 Putative cytochrome P450-family protein SCO7417 0.0006
4937 Cytochrome oxidase subunit II rcoxA 0.0006
4926 Heme-based aerotactic transducer hemAT hemAT 0.0006
4999 Cytochrome P450 165B3 CYP165B3 0.0006
4952 Catalase/peroxidase katA 0.0006
4922 Cytochrome c, putative SO_4144 0.0006
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0006
4903 Methyl-accepting chemotaxis protein Tar4 0.0006
6167 Organic solute transporter subunit beta OSTB 0.0006
3093 Catalase HPII katE 0.0006
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0006
6166 Organic solute transporter subunit alpha OSTA 0.0006
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0006
3611 Cytidine deaminase cdd 0.0006
3707 Cytidine deaminase cdd 0.0006
4211 Cytidine deaminase CDA 0.0006
936 Ephrin type-A receptor 2 EPHA2 0.0006
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.0006
1291 cAMP response element-binding protein CREB1 0.0006
1569 G1/S-specific cyclin-D1 CCND1 0.0006
1525 Heparin-binding growth factor 2 FGF2 0.0006
635 Estradiol 17-beta-dehydrogenase 8 HSD17B8 0.0006
666 NADP-dependent malic enzyme ME1 0.0006
857 Malate dehydrogenase, mitochondrial MDH2 0.0005
419 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial HADH 0.0005
4210 Toll-like receptor 4 TLR4 0.0005
77 L-lactate dehydrogenase B chain LDHB 0.0005
2808 Chloramphenicol acetyltransferase 3 cat3 0.0005
12 Alcohol dehydrogenase class 3 ADH5 0.0005
1341 Histamine H3 receptor HRH3 0.0005
1760 Aminopeptidase N ANPEP 0.0005
6843 Aminopeptidase N pepN 0.0005
1262 Corticotropin-lipotropin POMC 0.0005
296 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial MTHFD2 0.0005
6026 Alcohol dehydrogenase 6 ADH6 0.0005
117 Sterol O-acyltransferase 1 SOAT1 0.0005
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0005
248 Pyrroline-5-carboxylate reductase 1 PYCR1 0.0005
802 Pyrroline-5-carboxylate reductase 2 PYCR2 0.0005
11 NAD(P) transhydrogenase, mitochondrial NNT 0.0005
110 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial PDHB 0.0005
626 Cysteine dioxygenase type 1 CDO1 0.0005
627 11-cis retinol dehydrogenase RDH5 0.0005
640 Aldehyde dehydrogenase 1A3 ALDH1A3 0.0005
599 Glyceraldehyde-3-phosphate dehydrogenase GAPDH 0.0005
4426 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0005
4454 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0005
4489 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0005
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0005
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0005
794 Glyceraldehyde-3-phosphate dehydrogenase, testis-specific GAPDHS 0.0005
244 Angiotensin-converting enzyme ACE 0.0005
74 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial DLAT 0.0005
6211 Tubulin epsilon chain TUBE1 0.0005
6212 Tubulin gamma-1 chain TUBG1 0.0005
6210 Tubulin delta chain TUBD1 0.0005
13 Aminomethyltransferase, mitochondrial AMT 0.0005
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0005
2417 Chloramphenicol acetyltransferase cat 0.0005
3278 Chloramphenicol acetyltransferase cat 0.0005
2810 Dr hemagglutinin structural subunit draA 0.0005
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0005
166 NAD-dependent malic enzyme, mitochondrial ME2 0.0005
83 Alpha-aminoadipic semialdehyde synthase, mitochondrial AASS 0.0005
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0005
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0005
57 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I HSD3B1 0.0005
679 C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 0.0005
279 Tyrosinase TYR 0.0005
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0004
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0004
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0004
1992 Vitamin D-binding protein GC 0.0004
654 Flavin reductase BLVRB 0.0004
4920 Peroxidase/catalase katG 0.0004
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0004
4923 Cytochrome c3 DvMF_2499 0.0004
4945 Cytochrome c3 Not Available 0.0004
4949 Cytochrome c3 DVU_3171 0.0004
4968 Cytochrome c3 cytc3 0.0004
4997 Cytochrome c3 SO_2727 0.0004
5219 Cytochrome c3 cyd 0.0004
4948 Cytochrome c-553 Not Available 0.0004
2119 Cytochrome b5 CYB5A 0.0004
4037 Hypothetical protein GPX1 0.0004
4297 Hypothetical protein SP_1951 0.0004
4521 Hypothetical protein BC_2969 0.0004
4540 Hypothetical protein TM_1070 0.0004
4555 Hypothetical protein MT1739 0.0004
4569 Hypothetical protein mshD 0.0004
4578 Hypothetical protein PA3270 0.0004
4747 Hypothetical protein PA3967 0.0004
5177 Hypothetical protein TM_0096 0.0004
5194 Hypothetical protein PA1204 0.0004
5240 Hypothetical protein Rv2991 0.0004
5370 Hypothetical protein TM_1158 0.0004
5710 Hypothetical protein Tb927.5.1360 0.0004
3189 High-molecular-weight cytochrome c hmcA 0.0004
4902 Nine-heme cytochrome c Ddes_2038 0.0004
4990 PpcA ppcA 0.0004
4289 Cytochrome P450 TT_P0059 0.0004
6262 Cytochrome P450 staP 0.0004
4992 Cytochrome c peroxidase Not Available 0.0004
3570 Cytochrome P450 152A1 cypC 0.0004
4988 Sulfite oxidase, mitochondrial SUOX 0.0004
2915 Sensor protein fixL fixL 0.0004
4944 Sensor protein fixL fixL 0.0004
3375 Acidic cytochrome c3 Not Available 0.0004
4813 Heme oxygenase hmuO 0.0004
5769 Heme oxygenase Not Available 0.0004
4385 Cytochrome c' Not Available 0.0004
4967 Cytochrome c' cycA 0.0004
5038 Cytochrome c' Not Available 0.0004
5223 Cytochrome c' cycP 0.0004
4103 Proteasome subunit beta type 2 PSMB2 0.0004
4101 Proteasome subunit beta type 1 PSMB1 0.0004
4102 Proteasome subunit beta type 5 PSMB5 0.0004
1630 Integrin beta-2 ITGB2 0.0004
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0004
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0004
1063 Signal transducer and activator of transcription 5B STAT5B 0.0004
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0004
2216 Fibroblast growth factor receptor 4 FGFR4 0.0004
4217 Telomerase reverse transcriptase TERT 0.0004
3670 Soluble cytochrome b562 precursor cybC 0.0004
511 5-hydroxytryptamine 1F receptor HTR1F 0.0004
3411 Cytochrome P450 121 cyp121 0.0004
1176 Mitogen-activated protein kinase 1 MAPK1 0.0004
2617 Nitric oxide synthase oxygenase nos 0.0004
2701 Nitric oxide synthase oxygenase nos 0.0004
3291 Cytochrome c-552 cycA 0.0004
4927 Cytochrome c-552 nrfA 0.0004
4938 Cytochrome c-552 cycA 0.0004
4953 Cytochrome c-552 nrfA 0.0004
5217 Cytochrome c-552 cycM 0.0004
4386 Hemoglobin-like protein HbN glbN 0.0004
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0004
594 Thyroxine-binding globulin SERPINA7 0.0004
6048 Troponin C, skeletal muscle TNNC2 0.0004
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0004
719 Retinoic acid receptor responder protein 1 RARRES1 0.0003
770 Retinoic acid-induced protein 3 GPRC5A 0.0003
3127 Nitrite reductase nirS 0.0003
3284 Nitrite reductase nirS 0.0003
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0003
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0003
2972 6-deoxyerythronolide B hydroxylase eryF 0.0003
6044 Serum paraoxonase/lactonase 3 PON3 0.0003
758 Thyroid hormone receptor alpha THRA 0.0003
484 Tyrosine-protein kinase ABL2 ABL2 0.0003
2240 Cell division protein kinase 2 CDK2 0.0003
4608 Putative cytochrome P450 SCO1207 0.0003
4963 Putative cytochrome P450 SCO2884 0.0003
6254 Putative cytochrome P450 SCO6998 0.0003
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0003
572 Integrin alpha-L ITGAL 0.0003
5798 Mitogen-activated protein kinase 11 MAPK11 0.0003
199 Monocarboxylate transporter 8 SLC16A2 0.0003
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0003
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0003
2320 Thymidine kinase, cytosolic TK1 0.0003
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0003
267 Plasminogen activator inhibitor 1 SERPINE1 0.0003
1864 RET proto-oncogene RET 0.0003
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0003
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0003
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0003
346 Thyroid hormone receptor beta-1 THRB 0.0003
1507 Cytochrome c CYCS 0.0003
693 Hemoglobin subunit beta HBB 0.0003
760 Fibroblast growth factor 1 FGF1 0.0003
6221 Steroid hormone receptor ERR1 ESRRA 0.0003
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0003
6268 Hydroxyacid oxidase 1 HAO1 0.0003
5934 Cytochrome P450 26A1 CYP26A1 0.0003
6218 Pannexin-1 PANX1 0.0003
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0003
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0003
1039 Histone deacetylase 9 HDAC9 0.0003
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0002
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0002
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0002
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0002
162 Retinoic acid receptor gamma-1 RARG 0.0002
6135 Sodium channel subunit beta-4 SCN4B 0.0002
6134 Sodium channel subunit beta-3 SCN3B 0.0002
6132 Sodium channel subunit beta-1 SCN1B 0.0002
6127 Carbonic anhydrase-related protein CA8 0.0002
6128 Carbonic anhydrase-related protein 10 CA10 0.0002
6133 Sodium channel subunit beta-2 SCN2B 0.0002
6129 Carbonic anhydrase-related protein 11 CA11 0.0002
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0002
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0002
6130 Carbonic anhydrase 13 CA13 0.0002
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0002
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