DT-Web: DB01186

Identification

Name

Pergolide

Accession Number

DB01186 (APRD00663)

Type

small molecule

Description

Pergolide is a long-acting dopamine agonist approved in 1982 for the treatment of Parkinson's Disease. It is an ergot derivative that acts on the dopamine D2 and D3, alpha2- and alpha1-adrenergic, and 5-hydroxytryptamine (5-HT) receptors. It was indicated as adjunct therapy with levodopa/carbidopa in the symptomatic treatment of parkinsonian syndrome. It was later found that pergolide increased the risk of cardiac valvulopathy. The drug was withdrawn from the US market in March 2007 and from the Canadian market in August 2007.

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

314.488

Groups

approved

Monoisotopic Weight

314.181669532

Pharmacology

Indication

Indicated as adjunctive treatment to levodopa/carbidopa in the management of the signs and symptoms of Parkinson's disease. It was withdrawn from the US and Canadian markets in 2007 due to an increased risk of cardiac valvulopathy.

Mechanism of action

The dopamine D₂ receptor is a 7-transmembrane G-protein coupled receptor associated with G_i proteins. In lactotrophs, stimulation of dopamine D₂ receptor causes inhibition of adenylyl cyclase, which decreases intracellular cAMP concentrations and blocks IP3-dependent release of Ca²⁺ from intracellular stores. Decreases in intracellular calcium levels may also be brought about via inhibition of calcium influx through voltage-gated calcium channels, rather than via inhibition of adenylyl cyclase. Additionally, receptor activation blocks phosphorylation of p42/p44 MAPK and decreases MAPK/ERK kinase phosphorylation. Inhibition of MAPK appears to be mediated by c-Raf and B-Raf-dependent inhibition of MAPK/ERK kinase. Dopamine-stimulated growth hormone release from the pituitary gland is mediated by a decrease in intracellular calcium influx through voltage-gated calcium channels rather than via adenylyl cyclase inhibition. Stimulation of dopamine D₂ receptors in the nigrostriatal pathway leads to improvements in coordinated muscle activity in those with movement disorders.

Absorption

Significant amount may be absorbed (evidence on bioavailability still lacking).

Protein binding

90%

Biotransformation

Extensively hepatic.

Route of elimination

The major route of excretion is the kidney.

Toxicity

Oral, rat LD₅₀: 15 mg/kg. Symptoms of overdose include nausea, vomiting, convulsions, decreased blood pressure, and CNS stimulation.

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Tamoxifen	Pergolide may decrease the therapeutic effect of Tamoxifen by decreasing the production of active metabolites. Concomitant therapy should be avoided.
Tamsulosin	Pergolide, a CYP2D6 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP2D6 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Pergolide is initiated, discontinued, or dose changed.
Telithromycin	Telithromycin may reduce clearance of Pergolide. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Pergolide if Telithromycin is initiated, discontinued or dose changed.
Thiothixene	Thiothixene may antaonize the effects of the anti-Parkinsonian agent, Pergolide. Consider alternate therapy or monitor for decreased effects of both agents.
Tipranavir	Tipranavir may increase the plasma concentration of Pergolide. Concomitant therapy should be avoided.
Tolterodine	Peroglide may decrease the metabolism and clearance of Tolterodine. Monitor for adverse/toxic effects of Tolterodine.
Tramadol	Pergolide may decrease the effect of Tramadol by decreasing active metabolite production. Increased risk of serotonin syndrome. Monitor for Tramadol efficacy and symptoms of serotonin syndrome.
Tranylcypromine	Increased risk of serotonin syndrome. Use caution during concomitant therapy and monitor for symptoms of serotonin syndrome.
Trazodone	Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Trimipramine	Increased risk of serotonin syndrome. Pergolide, a strong CYP2D6 inhibitor, may also decrease the metabolism and clearance of Trimipramine, a CYP2D6 substrate. Monitor for symptoms of serotonin syndrome and changes in Trimipramine therapeutic and adverse effects if Pergolide is initiated, discontinued or dose changed.
Venlafaxine	Increased risk of serotonin syndrome. Monitor for symptoms of serotonin syndrome.
Voriconazole	Voriconazole may increase the serum concentration of pergolide likely by decreasing its metabolism. Concomitant therapy is contraindicated.
Ziprasidone	The atypical antipsychotic, ziprasidone, may antagonize the effect of the dopamine agonist, pergolide. Consider alternate therapy or monitor for worsening of movement disorder.
Zolmitriptan	Concomitant use of the serotonin 5-HT1D receptor agonist, zolmitriptan, and the ergot derivative, pergolide, may result in additive vasoconstrictive effects. Concomitant use within 24 hours is contraindicated.
Zuclopenthixol	Antagonism may occur between zuclopenthixol, a dopamine D2 receptor antagonist, and pergolide, a dopamine agonist. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of both agents if concurrent therapy is initiated, discontinued or dose(s) changed. Pergolide, a strong CYP2D6 inhibitor, may increase the serum concentration of zuclopenthixol by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of zuclopenthixol if pergolide is initiated, discontinued or dose changed.

Food Interactions

Take with food to reduce gastric irritation and nausea

D(2) dopamine receptor
Name	D(2) dopamine receptor
Gene Name	DRD2
Pharmacological action	yes
Actions	agonist
References	Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed Fuller RW, Hemrick-Luecke SK, Perry KW, Toomey RE: Pergolide elevation of MHPG sulphate concentration in rat hypothalamus blocked by spiperone and mimicked by other dopamine agonists. J Pharm Pharmacol. 1985 Apr;37(4):268-70. - Pubmed Huettl P, Gerhardt GA, Browning MD, Masserano JM: Effects of dopamine receptor agonists and antagonists on catecholamine release in bovine chromaffin cells. J Pharmacol Exp Ther. 1991 May;257(2):567-74. - Pubmed Kvernmo T, Houben J, Sylte I: Receptor-binding and pharmacokinetic properties of dopaminergic agonists. Curr Top Med Chem. 2008;8(12):1049-67. - Pubmed Lam YW: Clinical pharmacology of dopamine agonists. Pharmacotherapy. 2000 Jan;20(1 Pt 2):17S-25S. - Pubmed Linazasoro G, Obeso JA, Gomez JC, Martinez M, Antonini A, Leenders KL: Modification of dopamine D2 receptor activity by pergolide in Parkinson's disease: an in vivo study by PET. Clin Neuropharmacol. 1999 Sep-Oct;22(5):277-80. - Pubmed Mehta MA, Riedel WJ: Dopaminergic enhancement of cognitive function. Curr Pharm Des. 2006;12(20):2487-500. - Pubmed Paturle L, Fage D, Fourrier O, Vernier P, Feuerstein C, Demenge P, Scatton B: Cortical ablation fails to influence striatal dopamine target cell supersensitivity induced by nigrostriatal denervation in the rat. Brain Res. 1987 Feb 3;402(2):383-6. - Pubmed
DTHybrid score	0.9846
D(3) dopamine receptor
Name	D(3) dopamine receptor
Gene Name	DRD3
Pharmacological action	yes
Actions	agonist
References	Kvernmo T, Houben J, Sylte I: Receptor-binding and pharmacokinetic properties of dopaminergic agonists. Curr Top Med Chem. 2008;8(12):1049-67. - Pubmed Lam YW: Clinical pharmacology of dopamine agonists. Pharmacotherapy. 2000 Jan;20(1 Pt 2):17S-25S. - Pubmed Wachtel H: Antiparkinsonian dopamine agonists: a review of the pharmacokinetics and neuropharmacology in animals and humans. J Neural Transm Park Dis Dement Sect. 1991;3(3):151-201. - Pubmed
DTHybrid score	0.6062
D(4) dopamine receptor
Name	D(4) dopamine receptor
Gene Name	DRD4
Pharmacological action	unknown
Actions	agonist
References	Kvernmo T, Houben J, Sylte I: Receptor-binding and pharmacokinetic properties of dopaminergic agonists. Curr Top Med Chem. 2008;8(12):1049-67. - Pubmed
DTHybrid score	0.5786
5-hydroxytryptamine 1A receptor
Name	5-hydroxytryptamine 1A receptor
Gene Name	HTR1A
Pharmacological action	unknown
Actions	agonist
References	Kvernmo T, Houben J, Sylte I: Receptor-binding and pharmacokinetic properties of dopaminergic agonists. Curr Top Med Chem. 2008;8(12):1049-67. - Pubmed Lam YW: Clinical pharmacology of dopamine agonists. Pharmacotherapy. 2000 Jan;20(1 Pt 2):17S-25S. - Pubmed
DTHybrid score	0.7659
5-hydroxytryptamine 2B receptor
Name	5-hydroxytryptamine 2B receptor
Gene Name	HTR2B
Pharmacological action	unknown
Actions	agonist
References	Cussac D, Boutet-Robinet E, Ailhaud MC, Newman-Tancredi A, Martel JC, Danty N, Rauly-Lestienne I: Agonist-directed trafficking of signalling at serotonin 5-HT2A, 5-HT2B and 5-HT2C-VSV receptors mediated Gq/11 activation and calcium mobilisation in CHO cells. Eur J Pharmacol. 2008 Oct 10;594(1-3):32-8. Epub 2008 Jul 30. - Pubmed Kvernmo T, Houben J, Sylte I: Receptor-binding and pharmacokinetic properties of dopaminergic agonists. Curr Top Med Chem. 2008;8(12):1049-67. - Pubmed Lam YW: Clinical pharmacology of dopamine agonists. Pharmacotherapy. 2000 Jan;20(1 Pt 2):17S-25S. - Pubmed
DTHybrid score	0.4938
5-hydroxytryptamine 2A receptor
Name	5-hydroxytryptamine 2A receptor
Gene Name	HTR2A
Pharmacological action	unknown
Actions	agonist
References	Cussac D, Boutet-Robinet E, Ailhaud MC, Newman-Tancredi A, Martel JC, Danty N, Rauly-Lestienne I: Agonist-directed trafficking of signalling at serotonin 5-HT2A, 5-HT2B and 5-HT2C-VSV receptors mediated Gq/11 activation and calcium mobilisation in CHO cells. Eur J Pharmacol. 2008 Oct 10;594(1-3):32-8. Epub 2008 Jul 30. - Pubmed Kvernmo T, Houben J, Sylte I: Receptor-binding and pharmacokinetic properties of dopaminergic agonists. Curr Top Med Chem. 2008;8(12):1049-67. - Pubmed Lam YW: Clinical pharmacology of dopamine agonists. Pharmacotherapy. 2000 Jan;20(1 Pt 2):17S-25S. - Pubmed
DTHybrid score	0.8817
5-hydroxytryptamine 1D receptor
Name	5-hydroxytryptamine 1D receptor
Gene Name	HTR1D
Pharmacological action	unknown
Actions	agonist
References	Kvernmo T, Houben J, Sylte I: Receptor-binding and pharmacokinetic properties of dopaminergic agonists. Curr Top Med Chem. 2008;8(12):1049-67. - Pubmed Lam YW: Clinical pharmacology of dopamine agonists. Pharmacotherapy. 2000 Jan;20(1 Pt 2):17S-25S. - Pubmed
DTHybrid score	0.6017
Alpha-2B adrenergic receptor
Name	Alpha-2B adrenergic receptor
Gene Name	ADRA2B
Pharmacological action	unknown
Actions	agonist
References	Kvernmo T, Houben J, Sylte I: Receptor-binding and pharmacokinetic properties of dopaminergic agonists. Curr Top Med Chem. 2008;8(12):1049-67. - Pubmed Lam YW: Clinical pharmacology of dopamine agonists. Pharmacotherapy. 2000 Jan;20(1 Pt 2):17S-25S. - Pubmed
DTHybrid score	0.7125
Alpha-2A adrenergic receptor
Name	Alpha-2A adrenergic receptor
Gene Name	ADRA2A
Pharmacological action	unknown
Actions	agonist
References	Kvernmo T, Houben J, Sylte I: Receptor-binding and pharmacokinetic properties of dopaminergic agonists. Curr Top Med Chem. 2008;8(12):1049-67. - Pubmed Lam YW: Clinical pharmacology of dopamine agonists. Pharmacotherapy. 2000 Jan;20(1 Pt 2):17S-25S. - Pubmed
DTHybrid score	0.9459
Alpha-2C adrenergic receptor
Name	Alpha-2C adrenergic receptor
Gene Name	ADRA2C
Pharmacological action	unknown
Actions	agonist
References	Kvernmo T, Houben J, Sylte I: Receptor-binding and pharmacokinetic properties of dopaminergic agonists. Curr Top Med Chem. 2008;8(12):1049-67. - Pubmed Lam YW: Clinical pharmacology of dopamine agonists. Pharmacotherapy. 2000 Jan;20(1 Pt 2):17S-25S. - Pubmed
DTHybrid score	0.6842
D(1B) dopamine receptor
Name	D(1B) dopamine receptor
Gene Name	DRD5
Pharmacological action	unknown
Actions	agonist
References	Kvernmo T, Houben J, Sylte I: Receptor-binding and pharmacokinetic properties of dopaminergic agonists. Curr Top Med Chem. 2008;8(12):1049-67. - Pubmed
DTHybrid score	0.5298
D(1A) dopamine receptor
Name	D(1A) dopamine receptor
Gene Name	DRD1
Pharmacological action	unknown
Actions	agonist
References	Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed Kvernmo T, Houben J, Sylte I: Receptor-binding and pharmacokinetic properties of dopaminergic agonists. Curr Top Med Chem. 2008;8(12):1049-67. - Pubmed Lam YW: Clinical pharmacology of dopamine agonists. Pharmacotherapy. 2000 Jan;20(1 Pt 2):17S-25S. - Pubmed
DTHybrid score	0.8533
5-hydroxytryptamine 1B receptor
Name	5-hydroxytryptamine 1B receptor
Gene Name	HTR1B
Pharmacological action	unknown
Actions	agonist
References	Kvernmo T, Houben J, Sylte I: Receptor-binding and pharmacokinetic properties of dopaminergic agonists. Curr Top Med Chem. 2008;8(12):1049-67. - Pubmed Lam YW: Clinical pharmacology of dopamine agonists. Pharmacotherapy. 2000 Jan;20(1 Pt 2):17S-25S. - Pubmed
DTHybrid score	0.6063
5-hydroxytryptamine 2C receptor
Name	5-hydroxytryptamine 2C receptor
Gene Name	HTR2C
Pharmacological action	unknown
Actions	agonist
References	Cussac D, Boutet-Robinet E, Ailhaud MC, Newman-Tancredi A, Martel JC, Danty N, Rauly-Lestienne I: Agonist-directed trafficking of signalling at serotonin 5-HT2A, 5-HT2B and 5-HT2C-VSV receptors mediated Gq/11 activation and calcium mobilisation in CHO cells. Eur J Pharmacol. 2008 Oct 10;594(1-3):32-8. Epub 2008 Jul 30. - Pubmed Kvernmo T, Houben J, Sylte I: Receptor-binding and pharmacokinetic properties of dopaminergic agonists. Curr Top Med Chem. 2008;8(12):1049-67. - Pubmed Lam YW: Clinical pharmacology of dopamine agonists. Pharmacotherapy. 2000 Jan;20(1 Pt 2):17S-25S. - Pubmed
DTHybrid score	0.6766
Alpha-1A adrenergic receptor
Name	Alpha-1A adrenergic receptor
Gene Name	ADRA1A
Pharmacological action	unknown
Actions	agonist
References	Lam YW: Clinical pharmacology of dopamine agonists. Pharmacotherapy. 2000 Jan;20(1 Pt 2):17S-25S. - Pubmed
DTHybrid score	0.9094
Alpha-1B adrenergic receptor
Name	Alpha-1B adrenergic receptor
Gene Name	ADRA1B
Pharmacological action	unknown
Actions	agonist
References	Lam YW: Clinical pharmacology of dopamine agonists. Pharmacotherapy. 2000 Jan;20(1 Pt 2):17S-25S. - Pubmed
DTHybrid score	0.6766
Alpha-1D adrenergic receptor
Name	Alpha-1D adrenergic receptor
Gene Name	ADRA1D
Pharmacological action	unknown
Actions	agonist
References	Lam YW: Clinical pharmacology of dopamine agonists. Pharmacotherapy. 2000 Jan;20(1 Pt 2):17S-25S. - Pubmed
DTHybrid score	0.4437

Cytochrome P450 3A4
Name	Cytochrome P450 3A4
Gene Name	CYP3A4
Actions	substrate,inhibitor
References	Kvernmo T, Houben J, Sylte I: Receptor-binding and pharmacokinetic properties of dopaminergic agonists. Curr Top Med Chem. 2008;8(12):1049-67. - Pubmed Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.748
Cytochrome P450 2D6
Name	Cytochrome P450 2D6
Gene Name	CYP2D6
Actions	inhibitor
References	Kvernmo T, Houben J, Sylte I: Receptor-binding and pharmacokinetic properties of dopaminergic agonists. Curr Top Med Chem. 2008;8(12):1049-67. - Pubmed Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.783

Id	Partner name	Gene Name	Score
4200	Cytochrome P450 1A2	CYP1A2	0.4419
1588	Multidrug resistance protein 1	ABCB1	0.3313
492	Histamine H1 receptor	HRH1	0.2998
716	5-hydroxytryptamine 7 receptor	HTR7	0.2982
103	Muscarinic acetylcholine receptor M1	CHRM1	0.2319
6016	Cytochrome P450 2C19	CYP2C19	0.22
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.2092
4757	Cytochrome P450 2C9	CYP2C9	0.208
4118	Cytochrome P450 3A5	CYP3A5	0.2058
824	Sodium-dependent serotonin transporter	SLC6A4	0.2033
274	Muscarinic acetylcholine receptor M5	CHRM5	0.1856
617	Muscarinic acetylcholine receptor M2	CHRM2	0.1814
450	Muscarinic acetylcholine receptor M4	CHRM4	0.1805
51	Muscarinic acetylcholine receptor M3	CHRM3	0.1777
1256	5-hydroxytryptamine 6 receptor	HTR6	0.1723
3941	Amine oxidase [flavin-containing] A	MAOA	0.1655
6107	Cytochrome P450 3A7	CYP3A7	0.1601
766	Beta-2 adrenergic receptor	ADRB2	0.1599
193	Beta-1 adrenergic receptor	ADRB1	0.1585
6145	Solute carrier family 22 member 1	SLC22A1	0.1478
6013	Cytochrome P450 2E1	CYP2E1	0.1407
511	5-hydroxytryptamine 1F receptor	HTR1F	0.1294
528	5-hydroxytryptamine 1E receptor	HTR1E	0.1241
713	Sodium-dependent dopamine transporter	SLC6A3	0.1226
1181	Alpha-1-acid glycoprotein 1	ORM1	0.1181
4924	Cytochrome P450 2C8	CYP2C8	0.1128
341	5-hydroxytryptamine 3 receptor	HTR3A	0.1099
6030	Cytochrome P450 2B6	CYP2B6	0.1007
587	Serum albumin	ALB	0.0992
6144	Solute carrier family 22 member 2	SLC22A2	0.0941
131	Synaptic vesicular amine transporter	SLC18A2	0.0891
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0871
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0773
6024	Cytochrome P450 1A1	CYP1A1	0.0701
1517	Beta-3 adrenergic receptor	ADRB3	0.0684
6147	Solute carrier family 22 member 3	SLC22A3	0.0665
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.059
5718	Cytochrome P450 2A6	CYP2A6	0.0583
3923	Cholinesterase	BCHE	0.0568
94	5-hydroxytryptamine 4 receptor	HTR4	0.0556
118	Organic cation/carnitine transporter 2	SLC22A5	0.0538
465	Calmodulin	CALM1	0.049
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0471
124	Histamine H2 receptor	HRH2	0.047
828	Phenylalanine-4-hydroxylase	PAH	0.0449
3109	Phenylalanine-4-hydroxylase	phhA	0.0449
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.043
174	Sigma 1-type opioid receptor	SIGMAR1	0.0426
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0413
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0413
3939	Amine oxidase [flavin-containing] B	MAOB	0.0404
6070	Nischarin	NISCH	0.0397
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0374
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0366
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0356
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.0355
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0342
20	Prostaglandin G/H synthase 1	PTGS1	0.0337
6151	Monocarboxylate transporter 10	SLC16A10	0.0292
6020	Aldehyde oxidase	AOX1	0.0291
474	Acetylcholinesterase	ACHE	0.029
6106	Cytochrome P450 2C18	CYP2C18	0.0275
847	Mu-type opioid receptor	OPRM1	0.0275
696	Kappa-type opioid receptor	OPRK1	0.0269
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.0252
1636	Trace amine-associated receptor 1	TAAR1	0.0243
866	Large neutral amino acids transporter small subunit 2	SLC7A8	0.0243
6138	Multidrug resistance protein 3	ABCB4	0.0235
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0231
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.0227
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0227
467	Delta-type opioid receptor	OPRD1	0.0221
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.022
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0219
1898	Cytochrome P450 1B1	CYP1B1	0.0218
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0214
3811	Cytochrome P450 19A1	CYP19A1	0.0208
3810	Catechol O-methyltransferase	COMT	0.0203
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0202
164	Histamine H4 receptor	HRH4	0.0202
833	Organic cation/carnitine transporter 1	SLC22A4	0.0196
6432	Transporter	snf	0.0195
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0191
3426	Glutamine synthetase	glnA	0.0189
3987	Glutamine synthetase	GLUL	0.0189
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0184
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0183
871	Glucocorticoid receptor	NR3C1	0.0182
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0181
1656	CYP2B protein	CYP2B	0.0179
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0172
776	Bile salt export pump	ABCB11	0.0171
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0167
233	Potassium channel subfamily K member 2	KCNK2	0.0165
153	Dopamine beta-hydroxylase	DBH	0.0153
923	Glutamate receptor 3	GRIA3	0.0149
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0148
862	Multidrug resistance-associated protein 1	ABCC1	0.0148
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0148
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0147
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0142
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0142
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0141
731	HIV-1 protease	HIV-1 protease	0.0139
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0131
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0129
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.0123
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0118
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0118
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0118
1729	Solute carrier family 22 member 6	SLC22A6	0.0117
362	Melatonin receptor type 1B	MTNR1B	0.0115
571	Melatonin receptor type 1A	MTNR1A	0.0115
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0115
136	Estrogen receptor	ESR1	0.0107
921	Glutamate receptor 2	GRIA2	0.0103
904	Glutathione S-transferase P	GSTP1	0.0102
4120	NADPH--cytochrome P450 reductase	POR	0.0099
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0095
232	Corticosteroid-binding globulin	SERPINA6	0.0093
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0092
1680	Solute carrier family 2, facilitated glucose transporter member 1	SLC2A1	0.0089
3947	Xanthine dehydrogenase/oxidase	XDH	0.0089
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0084
380	Cytochrome P450 17A1	CYP17A1	0.0084
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0081
290	Prostaglandin G/H synthase 2	PTGS2	0.008
260	Cytochrome P450 51	ERG11	0.0079
761	Cytochrome P450 51	ERG11	0.0079
3163	Cytochrome P450 51	cyp51	0.0079
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0078
6859	Protein S100-A4	S100A4	0.0076
1618	High affinity nerve growth factor receptor	NTRK1	0.0075
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0075
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0075
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0074
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0073
614	Progesterone receptor	PGR	0.0072
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0072
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0072
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0071
6031	Cytochrome P450 3A43	CYP3A43	0.0071
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.007
817	DNA topoisomerase 2-alpha	TOP2A	0.007
6182	Cytochrome P450 2J2	CYP2J2	0.0069
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0069
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0069
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0066
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0065
6142	Solute carrier family 22 member 8	SLC22A8	0.0064
952	Dipeptidyl peptidase 4	DPP4	0.0061
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.006
161	Tubulin beta chain	TUBB	0.0058
312	Tubulin beta chain	TUB2	0.0058
818	50S ribosomal protein L10	rplJ	0.0058
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0057
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0057
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0055
6506	Stathmin-4	STMN4	0.0055
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0054
2164	Multidrug resistance-associated protein 4	ABCC4	0.0053
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0051
2112	Toll-like receptor 9	TLR9	0.0051
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.005
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.005
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0049
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0049
427	Substance-P receptor	TACR1	0.0049
173	Toll-like receptor 7	TLR7	0.0049
6143	Solute carrier family 22 member 7	SLC22A7	0.0049
468	Cytochrome P450 4A11	CYP4A11	0.0049
146	Androgen receptor	AR	0.0048
565	Extracellular calcium-sensing receptor	CASR	0.0046
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0046
504	Mast/stem cell growth factor receptor	KIT	0.0044
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0043
122	P2Y purinoceptor 12	P2RY12	0.0043
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0042
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0042
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0041
844	Epidermal growth factor receptor	EGFR	0.0041
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0041
856	Vitamin D3 receptor	VDR	0.004
29	Tubulin beta-1 chain	TUBB1	0.004
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.004
4604	Liver carboxylesterase 1	CES1	0.0039
694	Matrix protein 2	M	0.0039
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.0039
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0039
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0039
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0039
814	Ryanodine receptor 1	RYR1	0.0039
1129	C-C chemokine receptor type 5	CCR5	0.0039
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0038
592	Carbonic anhydrase 4	CA4	0.0038
6220	Aryl hydrocarbon receptor	AHR	0.0038
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0038
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0037
6148	Multidrug resistance-associated protein 7	ABCC10	0.0037
891	Dihydropteroate synthase	folP	0.0037
5359	Dihydropteroate synthase	folP	0.0037
7175	Dihydropteroate synthase	sulI	0.0037
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0037
295	Carbonic anhydrase 1	CA1	0.0036
68	Cannabinoid receptor 1	CNR1	0.0036
407	Vascular endothelial growth factor receptor 2	KDR	0.0036
4237	50S ribosomal protein L22	rplV	0.0035
185	Vasopressin V1a receptor	AVPR1A	0.0035
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0035
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0035
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0035
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0035
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0035
939	50S ribosomal protein L3	rplC	0.0035
811	Translocator protein	TSPO	0.0035
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0034
322	Vasopressin V2 receptor	AVPR2	0.0034
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0034
373	Transthyretin	TTR	0.0033
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.0033
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0033
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0033
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0032
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0032
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0032
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0032
777	Tumor necrosis factor	TNF	0.0032
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0032
140	30S ribosomal protein S9	rpsI	0.0031
6719	30S ribosomal protein S9	rpsI	0.0031
6725	30S ribosomal protein S9	rpsI	0.0031
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0031
1050	Bile salt sulfotransferase	SULT2A1	0.0031
6014	Cytochrome P450 2A13	CYP2A13	0.0031
365	Dihydrofolate reductase	DHFR	0.0031
2381	Dihydrofolate reductase	DFR1	0.0031
2833	Dihydrofolate reductase	Not Available	0.0031
2931	Dihydrofolate reductase	folA	0.0031
3544	Dihydrofolate reductase	folA	0.0031
3682	Dihydrofolate reductase	folA	0.0031
6642	Dihydrofolate reductase	folA	0.0031
6756	Dihydrofolate reductase	dfrA	0.0031
1629	Transcription factor AP-1	JUN	0.0031
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0031
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0031
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0031
70	Type-1 angiotensin II receptor	AGTR1	0.003
2578	Tubulin beta-3 chain	TUBB3	0.003
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.003
2285	Streptogramin A acetyltransferase	vatD	0.003
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.003
705	Glutamate receptor 1	GRIA1	0.003
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.003
6102	Arylamine N-acetyltransferase 2	NAT2	0.003
4203	Histamine N-methyltransferase	HNMT	0.003
6043	Putative G-protein coupled receptor 44	GPR44	0.003
1024	Solute carrier family 22 member 11	SLC22A11	0.0029
1178	Adenosine A2a receptor	ADORA2A	0.0029
1374	Natriuretic peptides B	NPPB	0.0029
1827	Gap junction alpha-1 protein	GJA1	0.0029
1908	Vascular cell adhesion protein 1	VCAM1	0.0029
6137	Multidrug resistance-associated protein 6	ABCC6	0.0029
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0029
756	Sex hormone-binding globulin	SHBG	0.0029
357	Carbonic anhydrase 2	CA2	0.0029
737	Mineralocorticoid receptor	NR3C2	0.0029
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0029
284	DNA-directed RNA polymerase beta chain	rpoB	0.0029
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0029
183	Vascular endothelial growth factor A	VEGFA	0.0028
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0028
3932	Glutathione S-transferase A2	GSTA2	0.0028
723	Cytosolic phospholipase A2	PLA2G4A	0.0027
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0027
26	Vascular endothelial growth factor receptor 3	FLT4	0.0027
2449	Tubulin alpha-3 chain	TUBA1A	0.0027
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0027
4173	Tyrosine-protein kinase JAK2	JAK2	0.0027
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0027
4228	Keratin, type II cytoskeletal 7	KRT7	0.0027
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0026
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0026
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0026
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0026
1010	Cytochrome P450 51A1	CYP51A1	0.0026
32	Vascular endothelial growth factor receptor 1	FLT1	0.0026
49	Endothelin B receptor	EDNRB	0.0026
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0025
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0025
869	Estrogen receptor beta	ESR2	0.0025
768	FK506-binding protein 1A	FKBP1A	0.0025
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0025
578	Endothelin-1 receptor	EDNRA	0.0024
544	Potassium voltage-gated channel subfamily E member 1	KCNE1	0.0024
1483	Membrane copper amine oxidase	AOC3	0.0024
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0024
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0024
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0024
5852	Type-2 angiotensin II receptor	AGTR2	0.0024
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0024
642	3-oxo-5-alpha-steroid 4-dehydrogenase 2	SRD5A2	0.0023
3086	Plasmepsin-2	Not Available	0.0023
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0023
543	Penicillin-binding protein 1B	mrcB	0.0023
6186	Penicillin-binding protein 1B	ponB	0.0023
6822	Penicillin-binding protein 1b	pbp1b	0.0023
6844	Penicillin-binding protein 1b	pbp1b	0.0023
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0022
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0022
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0022
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0022
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0022
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0022
159	Penicillin-binding protein 2B	penA	0.0022
6121	Penicillin-binding protein 2B	penA	0.0022
4122	Histone deacetylase 2	HDAC2	0.0022
581	Cytochrome P450 2R1	CYP2R1	0.0022
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0022
3404	Exotoxin A	eta	0.0022
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0022
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0022
298	Renin	REN	0.0021
16	Adenosine A1 receptor	ADORA1	0.0021
738	Monocarboxylate transporter 1	SLC16A1	0.0021
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0021
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0021
2539	Tubulin alpha-1 chain	TUBA4A	0.0021
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0021
63	Malate dehydrogenase	mdh	0.0021
2329	Malate dehydrogenase	mdh	0.0021
3445	Malate dehydrogenase	mdh	0.0021
4420	Malate dehydrogenase	mdh	0.0021
4438	Malate dehydrogenase	mdh	0.0021
6136	Multidrug resistance-associated protein 5	ABCC5	0.0021
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.002
6126	Carbonic anhydrase 7	CA7	0.002
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.002
6141	Sodium/bile acid cotransporter	SLC10A1	0.002
482	Glycine receptor subunit alpha-1	GLRA1	0.002
633	Penicillin-binding proteins 1A/1B	pbpA	0.0019
3856	Fibroblast growth factor receptor 3	FGFR3	0.0019
2499	Tubulin beta-2C chain	TUBB2C	0.0019
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0019
473	L-lactate dehydrogenase A chain	LDHA	0.0019
477	DNA topoisomerase 4 subunit A	parC	0.0019
886	DNA topoisomerase 4 subunit A	parC	0.0019
6226	DNA topoisomerase 4 subunit A	parC	0.0019
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0019
404	DNA gyrase subunit A	gyrA	0.0018
6224	DNA gyrase subunit A	gyrA	0.0018
893	[Citrate [pro-3S]-lyase] ligase	citC	0.0018
845	Pyruvate dehydrogenase [cytochrome]	poxB	0.0018
5998	Toll-like receptor 8	TLR8	0.0018
4238	50S ribosomal protein L4	rplD	0.0018
5578	50S ribosomal protein L4	rplD	0.0018
6173	50S ribosomal protein L4	rplD	0.0018
6219	50S ribosomal protein L4	rplD	0.0018
712	Tubulin alpha chain	TUB1	0.0018
1968	ATP-sensitive inward rectifier potassium channel 12	KCNJ12	0.0018
327	Glutathione reductase	gor	0.0018
5110	Glutathione reductase	GR2	0.0018
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0018
683	Potassium transporter	GK0582	0.0018
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.0018
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0017
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0017
613	Atrial natriuretic peptide receptor A	NPR1	0.0017
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0017
2290	ADP-ribosyl cyclase 2	BST1	0.0017
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.0017
165	FL cytokine receptor	FLT3	0.0017
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0017
4311	tRNA	TRDMT1	0.0017
4325	tRNA	trmD	0.0017
4328	tRNA	trmD	0.0017
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0017
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0017
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0017
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0017
518	Peroxidase/catalase T	katG	0.0017
144	Hemoglobin subunit alpha	HBA1	0.0016
4209	ATP-sensitive inward rectifier potassium channel 8	KCNJ8	0.0016
4773	Deoxycytidine kinase	DCK	0.0016
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0016
1852	Microtubule-associated protein 2	MAP2	0.0016
3233	Bile acid receptor	NR1H4	0.0015
5787	Angiopoietin-1 receptor	TEK	0.0015
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0015
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0015
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0015
982	Cocaine- and amphetamine-regulated transcript protein	CARTPT	0.0015
563	Thyroid peroxidase	TPO	0.0015
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0015
275	Arachidonate 5-lipoxygenase	ALOX5	0.0015
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0015
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0015
6824	Tyrosine-protein kinase Lyn	LYN	0.0014
1541	Metalloproteinase	mmp20	0.0014
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0014
634	Squalene monooxygenase	SQLE	0.0014
7196	Squalene monooxygenase	ERG1	0.0014
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0014
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.0014
1341	Histamine H3 receptor	HRH3	0.0014
1262	Corticotropin-lipotropin	POMC	0.0014
1192	Sulfotransferase 1A1	SULT1A1	0.0014
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0013
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0013
1353	DNA topoisomerase 1	TOP1	0.0013
3552	DNA topoisomerase 1	topA	0.0013
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0013
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0013
244	Angiotensin-converting enzyme	ACE	0.0013
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0013
6211	Tubulin epsilon chain	TUBE1	0.0013
6212	Tubulin gamma-1 chain	TUBG1	0.0013
6210	Tubulin delta chain	TUBD1	0.0013
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0013
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0013
860	Nicotinamide N-methyltransferase	NNMT	0.0013
699	Nicotinic acid receptor 1	GPR109A	0.0013
928	Nicotinic acid receptor 2	GPR109B	0.0013
583	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	QPRT	0.0013
2442	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0013
2459	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0013
6116	Gastric triacylglycerol lipase	LIPF	0.0012
780	Retinoic acid receptor RXR-gamma	RXRG	0.0012
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0012
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0012
3823	Cytokine receptor common gamma chain	IL2RG	0.0012
85	Growth hormone receptor	GHR	0.0012
1757	Myeloperoxidase	MPO	0.0012
2107	Microtubule-associated protein 1A	MAP1A	0.0012
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0012
338	DNA polymerase	UL30	0.0012
379	DNA polymerase	UL54	0.0012
697	DNA polymerase	ORF28	0.0012
2482	DNA polymerase	43	0.0012
4104	DNA polymerase	BALF5	0.0012
1295	Fatty acid synthase	FASN	0.0012
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0011
239	Coagulation factor X	F10	0.0011
88	Retinoic acid receptor RXR-beta	RXRB	0.0011
1992	Vitamin D-binding protein	GC	0.0011
754	Pancreatic triacylglycerol lipase	PNLIP	0.0011
7	Nitric oxide synthase, inducible	NOS2	0.0011
319	Opioid receptor, sigma 1	OPRS1	0.0011
707	72 kDa type IV collagenase	MMP2	0.0011
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0011
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0011
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0011
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0011
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0011
2178	Metabotropic glutamate receptor 5	GRM5	0.0011
724	Interleukin-2 receptor alpha chain	IL2RA	0.0011
717	Interleukin-2 receptor subunit beta	IL2RB	0.0011
54	Prothrombin	F2	0.001
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.001
4103	Proteasome subunit beta type 2	PSMB2	0.001
4102	Proteasome subunit beta type 5	PSMB5	0.001
4101	Proteasome subunit beta type 1	PSMB1	0.001
976	Platelet glycoprotein IX	GP9	0.001
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.001
2300	Lysozyme	E	0.001
3633	Lysozyme	R	0.001
5597	Lysozyme	17	0.001
1630	Integrin beta-2	ITGB2	0.001
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.001
1810	Protein S100-A1	S100A1	0.001
6097	Protein S100-A2	S100A2	0.001
3937	Fatty-acid amide hydrolase	FAAH	0.001
4116	Dihydropteroate synthetase	Not Available	0.001
469	Annexin A1	ANXA1	0.001
1144	Hepatocyte growth factor receptor	MET	0.001
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.001
493	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	0.001
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.001
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.001
2216	Fibroblast growth factor receptor 4	FGFR4	0.001
512	DNA-directed RNA polymerase alpha chain	rpoA	0.001
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.001
5300	Antigen peptide transporter 1	TAP1	0.001
4041	Microsomal glutathione S-transferase 2	MGST2	0.001
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.001
605	Fumarate reductase flavoprotein subunit	frdA	0.001
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.001
3673	Fumarate reductase flavoprotein subunit	fccA	0.001
4912	Fumarate reductase flavoprotein subunit	ifcA	0.001
6549	Fumarate reductase flavoprotein subunit	frdA	0.001
6146	High affinity copper uptake protein 1	SLC31A1	0.001
2268	Cholesterol oxidase	choB	0.0009
2822	Cholesterol oxidase	choA	0.0009
823	Fibroblast growth factor receptor 2	FGFR2	0.0009
1064	DNA (cytosine-5)-methyltransferase 1	DNMT1	0.0009
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0009
6105	3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	0.0009
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0009
65	Matrix metalloproteinase-9	Not Available	0.0009
459	Retinoic acid receptor RXR-alpha	RXRA	0.0009
1048	Protein S100-A13	S100A13	0.0009
2226	Protein S100-A12	S100A12	0.0009
6048	Troponin C, skeletal muscle	TNNC2	0.0009
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0009
1770	Phospholipase C	PLCL1	0.0009
2841	Phospholipase C	plc	0.0009
1648	Elastin	ELN	0.0009
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0009
84	Nuclear receptor 0B1	NR0B1	0.0009
6131	Carbonic anhydrase 14	CA14	0.0009
2283	Steroid Delta-isomerase	ksi	0.0009
2920	Steroid Delta-isomerase	ksi	0.0009
268	Adenosine A2b receptor	ADORA2B	0.0009
390	Adenosine A3 receptor	ADORA3	0.0009
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0009
2132	Protein S100-B	S100B	0.0009
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0008
6044	Serum paraoxonase/lactonase 3	PON3	0.0008
22	30S ribosomal protein S4	rpsD	0.0008
6714	30S ribosomal protein S4	rpsD	0.0008
6122	Carbonic anhydrase 3	CA3	0.0008
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0008
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0008
1867	Major prion protein	PRNP	0.0008
572	Integrin alpha-L	ITGAL	0.0008
2232	Interleukin-5	IL5	0.0008
1593	Mucin-2	MUC2	0.0008
4031	Glutathione S-transferase A1	GSTA1	0.0008
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0008
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0008
500	Monocarboxylate transporter 4	SLC16A3	0.0008
1649	Small inducible cytokine A2	CCL2	0.0008
1864	RET proto-oncogene	RET	0.0008
1025	Aquaporin-1	AQP1	0.0008
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0008
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0008
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0008
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0008
2091	Endoplasmin	HSP90B1	0.0008
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.0007
896	Glutathione S-transferase Mu 1	GSTM1	0.0007
1275	Estrogen sulfotransferase	SULT1E1	0.0007
461	Glycine receptor subunit alpha-3	GLRA3	0.0007
291	Nitric-oxide synthase, endothelial	NOS3	0.0007
130	Prostacyclin synthase	PTGIS	0.0007
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0007
6103	Arylamine N-acetyltransferase 1	NAT1	0.0007
760	Fibroblast growth factor 1	FGF1	0.0007
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0007
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0007
1268	Neuropeptide S receptor	NPSR1	0.0007
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0007
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0007
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0007
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0007
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0007
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0007
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0007
6207	30S ribosomal protein S14	rpsN	0.0007
6209	30S ribosomal protein S19	rpsS	0.0007
6712	30S ribosomal protein S19	rpsS	0.0007
6726	30S ribosomal protein S19	rpsS	0.0007
5934	Cytochrome P450 26A1	CYP26A1	0.0007
645	Penicillin-binding protein 1A	mrcA	0.0007
5805	Penicillin-binding protein 1A	ponA	0.0007
6185	Penicillin-binding protein 1A	mrcA	0.0007
6799	Penicillin-binding protein 1A	pbpA	0.0007
5924	Microtubule-associated protein 4	MAP4	0.0007
5923	Microtubule-associated protein tau	MAPT	0.0007
2298	Cytochrome P450-cam	camC	0.0007
24	Thymidylate synthase	TMP1	0.0007
359	Thymidylate synthase	TYMS	0.0007
2626	Thymidylate synthase	thyA	0.0007
2729	Thymidylate synthase	thyA	0.0007
5352	Thymidylate synthase	THYA	0.0007
751	Potassium channel subfamily K member 6	KCNK6	0.0007
226	Gonadotropin-releasing hormone receptor	GNRHR	0.0007
1830	5'-nucleotidase	NT5E	0.0007
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0007
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0007
125	DNA polymerase beta	POLB	0.0007
1123	Eosinophil cationic protein	RNASE3	0.0007
2599	Tyrosine-protein kinase HCK	HCK	0.0007
6073	Potassium channel subfamily K member 9	KCNK9	0.0006
6072	Potassium channel subfamily K member 3	KCNK3	0.0006
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0006
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0006
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0006
106	Cannabinoid receptor 2	CNR2	0.0006
6174	50S ribosomal protein L32	rpmF	0.0006
172	Potassium channel subfamily K member 1	KCNK1	0.0006
3809	Estrogen-related receptor gamma	ESRRG	0.0006
273	Apoptosis regulator Bcl-2	BCL2	0.0006
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0006
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0006
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0006
1196	Complement decay-accelerating factor	CD55	0.0006
6085	Fatty acid-binding protein, intestinal	FABP2	0.0006
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0006
4192	DNA topoisomerase 2-beta	TOP2B	0.0006
6167	Organic solute transporter subunit beta	OSTB	0.0006
6166	Organic solute transporter subunit alpha	OSTA	0.0006
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0006
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0006
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0006
3957	Adenosine deaminase	ADA	0.0006
6168	Solute carrier family 22 member 16	SLC22A16	0.0006
3611	Cytidine deaminase	cdd	0.0006
3707	Cytidine deaminase	cdd	0.0006
4211	Cytidine deaminase	CDA	0.0006
936	Ephrin type-A receptor 2	EPHA2	0.0006
1291	cAMP response element-binding protein	CREB1	0.0006
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0006
1569	G1/S-specific cyclin-D1	CCND1	0.0006
1525	Heparin-binding growth factor 2	FGF2	0.0006
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0006
4210	Toll-like receptor 4	TLR4	0.0005
2808	Chloramphenicol acetyltransferase 3	cat3	0.0005
1760	Aminopeptidase N	ANPEP	0.0005
6843	Aminopeptidase N	pepN	0.0005
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0005
117	Sterol O-acyltransferase 1	SOAT1	0.0005
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0005
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0005
2207	Rhodopsin	RHO	0.0005
2417	Chloramphenicol acetyltransferase	cat	0.0005
3278	Chloramphenicol acetyltransferase	cat	0.0005
2810	Dr hemagglutinin structural subunit	draA	0.0005
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0005
3601	Dihydropteroate synthase 1	folP1	0.0005
3807	Dihydropteroate synthase 1	folP1	0.0005
3808	Dihydropteroate synthase 2	folP2	0.0005
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0005
1714	Mitogen-activated protein kinase 3	MAPK3	0.0005
2236	Casein kinase II subunit alpha	CSNK2A1	0.0005
3913	Glutamic acid decarboxylase	GAD65	0.0005
6149	Solute carrier family 22 member 10	SLC22A10	0.0005
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0004
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0004
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0004
76	Nitric-oxide synthase, brain	NOS1	0.0004
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0004
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0004
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0004
4217	Telomerase reverse transcriptase	TERT	0.0004
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0004
735	Alanine aminotransferase 1	GPT	0.0004
3904	Alanine aminotransferase 2	GPT2	0.0004
1176	Mitogen-activated protein kinase 1	MAPK1	0.0004
251	Alcohol dehydrogenase 1A	ADH1A	0.0004
594	Thyroxine-binding globulin	SERPINA7	0.0004
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0004
719	Retinoic acid receptor responder protein 1	RARRES1	0.0003
770	Retinoic acid-induced protein 3	GPRC5A	0.0003
820	Glycine receptor subunit alpha-2	GLRA2	0.0003
758	Thyroid hormone receptor alpha	THRA	0.0003
444	Alcohol dehydrogenase 1B	ADH1B	0.0003
33	Cystine/glutamate transporter	SLC7A11	0.0003
484	Tyrosine-protein kinase ABL2	ABL2	0.0003
2240	Cell division protein kinase 2	CDK2	0.0003
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0003
5798	Mitogen-activated protein kinase 11	MAPK11	0.0003
199	Monocarboxylate transporter 8	SLC16A2	0.0003
2320	Thymidine kinase, cytosolic	TK1	0.0003
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0003
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0003
569	Retinal dehydrogenase 2	ALDH1A2	0.0003
267	Plasminogen activator inhibitor 1	SERPINE1	0.0003
346	Thyroid hormone receptor beta-1	THRB	0.0003
611	Retinal dehydrogenase 1	ALDH1A1	0.0003
517	Alcohol dehydrogenase 1C	ADH1C	0.0003
6221	Steroid hormone receptor ERR1	ESRRA	0.0003
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0003
6218	Pannexin-1	PANX1	0.0003
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0003
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0003
1039	Histone deacetylase 9	HDAC9	0.0003
908	Glutathione S-transferase theta-1	GSTT1	0.0003
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0002
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0002
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0002
162	Retinoic acid receptor gamma-1	RARG	0.0002
6135	Sodium channel subunit beta-4	SCN4B	0.0002
6134	Sodium channel subunit beta-3	SCN3B	0.0002
6132	Sodium channel subunit beta-1	SCN1B	0.0002
6127	Carbonic anhydrase-related protein	CA8	0.0002
6128	Carbonic anhydrase-related protein 10	CA10	0.0002
6133	Sodium channel subunit beta-2	SCN2B	0.0002
6129	Carbonic anhydrase-related protein 11	CA11	0.0002
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0002
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0002
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0002
6130	Carbonic anhydrase 13	CA13	0.0002
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0002
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0002
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0002
489	Monocarboxylate transporter 2	SLC16A7	0.0002
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0002
3007	Carbonic anhydrase 12	CA12	0.0002
4205	Carbonic anhydrase 9	CA9	0.0002
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0001
4936	Cytochrome c2 iso-2	Not Available	0.0001
4916	Cyanoglobin	glbN	0.0001
4994	Hemoglobin-like protein HbO	glbO	0.0001
4915	Cytochrome c-550	psbV	0.0001
4959	Cytochrome c-550	psbV	0.0001
5216	Cytochrome c-550	psbV	0.0001
4925	Cytochrome c-type protein SHP	shp	0.0001
4904	Cytochrome c family protein	GSU1996	0.0001
4943	Cytochrome c6	petJ	0.0001
3116	Bacterioferritin	bfr	0.0001
4906	Bacterioferritin	bfr	0.0001
4965	Bacterioferritin	bfr	0.0001
4954	Soluble cytochrome b558	Not Available	0.0001
4934	Cytochrome c-551	nirM	0.0001
5218	Cytochrome c-551	nirM	0.0001
4905	Cytochrome c2	Not Available	0.0001
4939	Cytochrome c2	cycA	0.0001
4964	Cytochrome c2	cycA	0.0001
4979	Cytochrome c2	cycA	0.0001
6673	Cytochrome c2	cycA	0.0001
4910	Cytoglobin	CYGB	0.0001
4984	Neuroglobin	NGB	0.0001
4981	Iron-starvation protein PigA	pigA	0.0001
4909	CooA protein	cooA	0.0001
4998	Hemoglobin-like protein yjbI	yjbI	0.0001
4935	Cytochrome c-554	cycA1	0.0001
4947	Bacterial hemoglobin	vhb	0.0001
4975	Cytochrome c-556	RPA3973	0.0001
4942	Diheme cytochrome c napB	napB	0.0001
4931	Cytochrome P450 167A1	CYP167A1	0.0001
5000	HemO	hemO	0.0001
4972	P450cin	cinA	0.0001
4960	Putative cytochrome P450-family protein	SCO7417	0.0001
4971	Nonaheme cytochrome c	hmcA	0.0001
4989	Cytochrome c551 peroxidase	ccp	0.0001
5222	Cytochrome c551 peroxidase	ccpA	0.0001
4961	Hemophore HasA	hasA	0.0001
4976	Apocytochrome f	petA	0.0001
6407	Apocytochrome f	petA	0.0001
4907	Cytochrome c-L	moxG	0.0001
6865	Cytochrome c-L	moxG	0.0001
4993	Hydroxylamine oxidoreductase	hao1	0.0001
4764	Cytochrome P450 165C4	CYP165C4	0.0001
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0001
644	Heme oxygenase 2	HMOX2	0.0001
4982	Heme oxygenase 2	pbsA2	0.0001
4952	Catalase/peroxidase	katA	0.0001
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0001
4937	Cytochrome oxidase subunit II	rcoxA	0.0001
4903	Methyl-accepting chemotaxis protein	Tar4	0.0001
4999	Cytochrome P450 165B3	CYP165B3	0.0001
3093	Catalase HPII	katE	0.0001
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0001
4922	Cytochrome c, putative	SO_4144	0.0001
4920	Peroxidase/catalase	katG	0.0001
4990	PpcA	ppcA	0.0001
4948	Cytochrome c-553	Not Available	0.0001
4923	Cytochrome c3	DvMF_2499	0.0001
4945	Cytochrome c3	Not Available	0.0001
4949	Cytochrome c3	DVU_3171	0.0001
4968	Cytochrome c3	cytc3	0.0001
4997	Cytochrome c3	SO_2727	0.0001
5219	Cytochrome c3	cyd	0.0001
2119	Cytochrome b5	CYB5A	0.0001
4902	Nine-heme cytochrome c	Ddes_2038	0.0001
3189	High-molecular-weight cytochrome c	hmcA	0.0001
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0001
3375	Acidic cytochrome c3	Not Available	0.0001
4988	Sulfite oxidase, mitochondrial	SUOX	0.0001
2915	Sensor protein fixL	fixL	0.0001
4944	Sensor protein fixL	fixL	0.0001
4813	Heme oxygenase	hmuO	0.0001
5769	Heme oxygenase	Not Available	0.0001
3570	Cytochrome P450 152A1	cypC	0.0001
4385	Cytochrome c'	Not Available	0.0001
4967	Cytochrome c'	cycA	0.0001
5038	Cytochrome c'	Not Available	0.0001
5223	Cytochrome c'	cycP	0.0001
4037	Hypothetical protein	GPX1	0.0001
4297	Hypothetical protein	SP_1951	0.0001
4521	Hypothetical protein	BC_2969	0.0001
4540	Hypothetical protein	TM_1070	0.0001
4555	Hypothetical protein	MT1739	0.0001
4569	Hypothetical protein	mshD	0.0001
4578	Hypothetical protein	PA3270	0.0001
4747	Hypothetical protein	PA3967	0.0001
5177	Hypothetical protein	TM_0096	0.0001
5194	Hypothetical protein	PA1204	0.0001
5240	Hypothetical protein	Rv2991	0.0001
5370	Hypothetical protein	TM_1158	0.0001
5710	Hypothetical protein	Tb927.5.1360	0.0001
4289	Cytochrome P450	TT_P0059	0.0001
6262	Cytochrome P450	staP	0.0001
4992	Cytochrome c peroxidase	Not Available	0.0001
2230	Catalase	CAT	0.0001
3249	Catalase	katA	0.0001
3625	Catalase	katA	0.0001
4539	Catalase	katA	0.0001
4941	Catalase	katB	0.0001
3670	Soluble cytochrome b562 precursor	cybC	0.0001
3411	Cytochrome P450 121	cyp121	0.0001
3291	Cytochrome c-552	cycA	0.0001
4927	Cytochrome c-552	nrfA	0.0001
4938	Cytochrome c-552	cycA	0.0001
4953	Cytochrome c-552	nrfA	0.0001
5217	Cytochrome c-552	cycM	0.0001
2617	Nitric oxide synthase oxygenase	nos	0.0001
2701	Nitric oxide synthase oxygenase	nos	0.0001
3102	Flavohemoprotein	hmp	0.0001
4969	Flavohemoprotein	hmp	0.0001
4386	Hemoglobin-like protein HbN	glbN	0.0001
3127	Nitrite reductase	nirS	0.0001
3284	Nitrite reductase	nirS	0.0001
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0001
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0001
3221	Cytochrome c4	cc4	0.0001
4608	Putative cytochrome P450	SCO1207	0.0001
4963	Putative cytochrome P450	SCO2884	0.0001
6254	Putative cytochrome P450	SCO6998	0.0001
358	Cystathionine beta-synthase	CBS	0
1507	Cytochrome c	CYCS	0
693	Hemoglobin subunit beta	HBB	0
6268	Hydroxyacid oxidase 1	HAO1	0
810	Heme oxygenase 1	HMOX1	0
3391	Heme oxygenase 1	pbsA1	0

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB01186 - Pergolide

Targets

Enzymes

Predictions