DT-Web

DB00951 - Isoniazid


Identification
Name Isoniazid
Accession Number DB00951 (APRD01055, EXPT01940)
Type small molecule
Description Antibacterial agent used primarily as a tuberculostatic. It remains the treatment of choice for tuberculosis. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 137.1393
Groups approved
Monoisotopic Weight 137.058911861
Pharmacology
Indication For the treatment of all forms of tuberculosis in which organisms are susceptible.
Mechanism of action Isoniazid is a prodrug and must be activated by bacterial catalase. Specficially, activation is associated with reduction of the mycobacterial ferric KatG catalase-peroxidase by hydrazine and reaction with oxygen to form an oxyferrous enzyme complex. Once activated, isoniazid inhibits the synthesis of mycoloic acids, an essential component of the bacterial cell wall. At therapeutic levels isoniazid is bacteriocidal against actively growing intracellular and extracellular Mycobacterium tuberculosis organisms. Specifically isoniazid inhibits InhA, the enoyl reductase from Mycobacterium tuberculosis, by forming a covalent adduct with the NAD cofactor. It is the INH-NAD adduct that acts as a slow, tight-binding competitive inhibitor of InhA.
Absorption Readily absorbed following oral administration; however, may undergo significant first pass metabolism. Absorption and bioavailability are reduced when isoniazid is administered with food.
Protein binding Very low (0-10%)
Biotransformation Primarily hepatic. Isoniazid is acetylated by N -acetyl transferase to N -acetylisoniazid; it is then biotransformed to isonicotinic acid and monoacetylhydrazine. Monoacetylhydrazine is associated with hepatotoxicity via formation of a reactive intermediate metabolite when N-hydroxylated by the cytochrome P450 mixed oxidase system. The rate of acetylation is genetically determined. Slow acetylators are characterized by a relative lack of hepatic N -acetyltransferase.
Route of elimination From 50 to 70 percent of a dose of isoniazid is excreted in the urine within 24 hours.
Toxicity LD50 100 mg/kg (Human, oral). Adverse reactions include rash, abnormal liver function tests, hepatitis, peripheral neuropathy, mild central nervous system (CNS) effects. In vivo, Isoniazid reacts with pyridoxal to form a hydrazone, and thus inhibits generation of pyridoxal phosphate. Isoniazid also combines with pyridoxal phosphate; high doses interfere with the coenzyme function of the latter.
Affected organisms
  • Mycobacteria
Interactions
Drug Interactions
Drug Mechanism of interaction
Acenocoumarol Isoniazid may increase the anticoagulant effect of acenocoumarol.
Acetaminophen Risk of hepatotoxicity
Aminophylline Isoniazid may increase the effect and toxicity of oxtriphylline.
Anisindione Isoniazid may increase the anticoagulant effect of anisindione.
Bromazepam Isoniazid, a strong CYP3A4 inhibitor, may increase the serum concentration of bromazepam by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of bromazepam if isoniazid is initiated, discontinued or dose changed. Dosage adjustments may be required.
Carbamazepine Carbamazepine effect is increased as is isoniazid toxicity
Carisoprodol Strong CYP2C19 inhibitors such as isoniazid may decrease the metabolism of CYP2C19 substrates such as carisoprodol. Consider an alternative for one of the interacting drugs in order to avoid toxicity of the substrate. Some combinations are specifically contraindicated by manufacturers. Suggested dosage adjustments are also offered by some manufacturers. Please review applicable package inserts. Monitor for increased effects of the CYP substrate if a CYP inhibitor is initiated/dose increased, and decreased effects if a CYP inhibitor is discontinued/dose decreased.
Dantrolene Isoniazid may increase the serum concentration of dantrolene by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of dantrolene if isoniazid is initiated, discontinued or dose changed.
Dicumarol Isoniazid may increase the anticoagulant effect of dicumarol.
Disulfiram Increased risk of CNS adverse effects
Dyphylline Increases the effect and toxicity of theophylline
Eltrombopag Affects hepatic CYP1A2 metabolism, increases Eltrombopag level or affect.
Ethotoin Isoniazid increases the effect of phenytoin in 20% of patients
Fosphenytoin Isoniazid may increase the effect of phenytoin in 20% of patients.
Ketoconazole Isoniazid decreases the effect of ketoconazole
Meperidine Possible episodes of hypotension
Mephenytoin Isoniazid increases the effect of phenytoin in 20% of patients
Oxtriphylline Isoniazid may increase the effect and toxicity of oxtriphylline.
Phenytoin Isoniazid increases the effect of phenytoin in 20% of patients
Tacrolimus The strong CYP3A4 inhibitor, Isoniazid, may decrease the metabolism and clearance of Tacrolimus, a CYP3A4 substrate. Consider alternate therapy or monitor for changes in therapeutic and adverse effects of Tacrolimus if Isoniazid is initiated, discontinued or dose changed.
Tadalafil Isoniazid may reduce the metabolism of Tadalafil. Concomitant therapy should be avoided if possible due to high risk of Tadalafil toxicity.
Tamoxifen Isoniazid may increase the serum concentration of Tamoxifen by decreasing its metabolism and clearance. Isoniazid may also decrease the therapeutic effect of Tamoxifen by decreasing active metabolite production. Monitor for changes in the therapeutic/adverse effects of Tamoxifen if Isoniazid is initiated, discontinued or dose changed.
Tamsulosin Isoniazid, a CYP3A4/2D6 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP3A4/2D6 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Isoniazid is initiated, discontinued, or dose changed.
Telithromycin Isoniazid may increase the plasma concentration of Telithromycin. Consider alternate therapy or monitor therapeutic/adverse effects.
Temsirolimus Isoniazid may inhibit the metabolism and clearance of Temsirolimus. Concomitant therapy should be avoided.
Teniposide The strong CYP3A4 inhibitor, Isoniazid, may decrease the metabolism and clearance of Teniposide, a CYP3A4 substrate. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Teniposide if Isoniazid is initiated, discontinued or dose changed.
Theophylline Isoniazid may increase the therapeutic and adverse effects of theophylline.
Tiagabine The strong CYP3A4 inhibitor, Isoniazid, may decrease the metabolism and clearance of Tiagabine, a CYP3A4 substrate. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Tiagabine if Isoniazid is initiated, discontinued or dose changed.
Tolterodine Isoniazid may decrease the metabolism and clearance of Tolterodine. Adjust Tolterodine dose and monitor for efficacy and toxicity.
Tramadol Isoniazid may increase Tramadol toxicity by decreasing Tramadol metabolism and clearance. Isoniazid may decrease the effect of Tramadol by decreasing active metabolite production.
Trazodone The CYP3A4 inhibitor, Isoniazid, may increase Trazodone efficacy/toxicity by decreasing Trazodone metabolism and clearance. Consider alternate therapy or monitor for changes in Trazodone efficacy/toxicity if Isoniazid is initiated, discontinued or dose changed.
Trimipramine The strong CYP3A4/CYP2C19 inhibitor, Isoniazide, may decrease the metabolism and clearance of Trimipramine, a CYP3A4/CYP2C19 substrate. Consider alternate therapy or monitor for changes in therapeutic and adverse effects of Trimipramine if Isoniazid is initiated, discontinued or dose changed.
Vardenafil Isoniazid, a strong CYP3A4 inhibitor, may reduce the metabolism and clearance of Vardenafil. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of Vardenafil.
Venlafaxine Isoniazid, a CYP3A4 inhibitor, may decrease the metabolism and clearance of Venlafaxine, a CYP3A4 substrate. Monitor for changes in therapeutic/adverse effects of Venlafaxine if Isoniazid is initiated, discontinued, or dose changed.
Verapamil Isoniazid, a strong CYP3A4 inhibitor, may increase the serum concentration of Veramapil, a CYP3A4 substrate, by decreasing its metabolism and clearance. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Verapamil if Isoniazid is initiated, discontinued or dose changed.
Vinblastine Isoniazid, a strong CYP3A4 inhibitor, may decrease the metabolism of Vinblastine. Consider alternate therapy to avoid Vinblastine toxicity. Monitor for changes in the therapeutic/adverse effects of Vinblastine if Isoniazid is initiated, discontinued or dose changed.
Vincristine Isoniazid, a strong CYP3A4 inhibitor, may increase the serum concentration of Vincristine by decreasing its metabolism. Consider alternate therapy to avoid Vincristine toxicity. Monitor for changes in the therapeutic and adverse effects of Vincristine if Isoniazid is initiated, discontinued or dose changed.
Vinorelbine Isoniazid, a strong CYP3A4 inhibitor, may increase the serum concentration of Vinorelbine by decreasing its metabolism. Consider alternate therapy to avoid Vinorelbine toxicity. Monitor for changes in the therapeutic and adverse effects of Vinorelbine if Isoniazid is initiated, discontinued or dose changed.
Warfarin Isoniazid may increase the anticoagulant effect of warfarin.
Zolpidem Isoniazid, a strong CYP3A4 inhibitor, may increase the serum concentration of zolpidem by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of zolpidem if isoniazid is initiated, discontinued or dose changed.
Zonisamide Isoniazid, a strong CYP3A4 inhibitor, may increase the serum concentration of zonisamide by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of zonisamide if isoniazid is initiated, discontinued or dose changed.
Zopiclone Isoniazid, a strong CYP3A4 inhibitor, may increase the serum concentration of zopiclone by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of zopiclone if isoniazid is initiated, discontinued or dose changed.
Food Interactions
  • Avoid aged foods (cheese, red wine), pickled foods, cured foods (bacon/ham), chocolate, fava beans, beer, unless approved by your physician.
  • Take on empty stomach: 1 hour before or 2 hours after meals.
  • Avoid alcohol.
  • Take with a full glass of water.
  • Do not take calcium, aluminum, magnesium or Iron supplements within 2 hours of taking this medication.
  • Increase dietary intake of magnesium, folate, vitamin B6, B12, and/or consider taking a multivitamin.

Targets


Peroxidase/catalase T
Name Peroxidase/catalase T
Gene Name katG
Pharmacological action yes
Actions other/unknown
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Pym AS, Domenech P, Honore N, Song J, Deretic V, Cole ST: Regulation of catalase-peroxidase (KatG) expression, isoniazid sensitivity and virulence by furA of Mycobacterium tuberculosis. Mol Microbiol. 2001 May;40(4):879-89. - Pubmed
  • Heym B, Alzari PM, Honore N, Cole ST: Missense mutations in the catalase-peroxidase gene, katG, are associated with isoniazid resistance in Mycobacterium tuberculosis. Mol Microbiol. 1995 Jan;15(2):235-45. - Pubmed
  • Wilson TM, de Lisle GW, Collins DM: Effect of inhA and katG on isoniazid resistance and virulence of Mycobacterium bovis. Mol Microbiol. 1995 Mar;15(6):1009-15. - Pubmed
  • Vilcheze C, Jacobs WR Jr: The mechanism of isoniazid killing: clarity through the scope of genetics. Annu Rev Microbiol. 2007;61:35-50. - Pubmed
DTHybrid score 0.4948
Enoyl-[acyl-carrier-protein] reductase [NADH]
Name Enoyl-[acyl-carrier-protein] reductase [NADH]
Gene Name inhA
Pharmacological action yes
Actions adduct
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Schroeder EK, Basso LA, Santos DS, de Souza ON: Molecular dynamics simulation studies of the wild-type, I21V, and I16T mutants of isoniazid-resistant Mycobacterium tuberculosis enoyl reductase (InhA) in complex with NADH: toward the understanding of NADH-InhA different affinities. Biophys J. 2005 Aug;89(2):876-84. Epub 2005 May 20. - Pubmed
  • Wilson TM, de Lisle GW, Collins DM: Effect of inhA and katG on isoniazid resistance and virulence of Mycobacterium bovis. Mol Microbiol. 1995 Mar;15(6):1009-15. - Pubmed
  • Broussy S, Coppel Y, Nguyen M, Bernadou J, Meunier B: 1H and 13C NMR characterization of hemiamidal isoniazid-NAD(H) adducts as possible inhibitors of InhA reductase of Mycobacterium tuberculosis. Chemistry. 2003 May 9;9(9):2034-8. - Pubmed
  • Vilcheze C, Jacobs WR Jr: The mechanism of isoniazid killing: clarity through the scope of genetics. Annu Rev Microbiol. 2007;61:35-50. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 1.6518

Enzymes


Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.7468
Cytochrome P450 2E1
Name Cytochrome P450 2E1
Gene Name CYP2E1
Actions substrate,inhibitor,inducer
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.406
Cytochrome P450 2C9
Name Cytochrome P450 2C9
Gene Name CYP2C9
Actions inhibitor
References
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.6226
Cytochrome P450 1A2
Name Cytochrome P450 1A2
Gene Name CYP1A2
Actions inhibitor
References
  • Wang B, Zhou SF: Synthetic and natural compounds that interact with human cytochrome P450 1A2 and implications in drug development. Curr Med Chem. 2009;16(31):4066-218. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.5277
Cytochrome P450 2D6
Name Cytochrome P450 2D6
Gene Name CYP2D6
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.5755
Cytochrome P450 2C19
Name Cytochrome P450 2C19
Gene Name CYP2C19
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.5225
Arylamine N-acetyltransferase 2
Name Arylamine N-acetyltransferase 2
Gene Name NAT2
Actions substrate
References
  • Upton AM, Mushtaq A, Victor TC, Sampson SL, Sandy J, Smith DM, van Helden PV, Sim E: Arylamine N-acetyltransferase of Mycobacterium tuberculosis is a polymorphic enzyme and a site of isoniazid metabolism. Mol Microbiol. 2001 Oct;42(2):309-17. - Pubmed
DTHybrid score 0.185
Arylamine N-acetyltransferase
Name Arylamine N-acetyltransferase
Gene Name nat
Actions inhibitor
References
  • Upton AM, Mushtaq A, Victor TC, Sampson SL, Sandy J, Smith DM, van Helden PV, Sim E: Arylamine N-acetyltransferase of Mycobacterium tuberculosis is a polymorphic enzyme and a site of isoniazid metabolism. Mol Microbiol. 2001 Oct;42(2):309-17. - Pubmed
DTHybrid score Not Available
Cytochrome P450 2A6
Name Cytochrome P450 2A6
Gene Name CYP2A6
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4018
Cytochrome P450 2C8
Name Cytochrome P450 2C8
Gene Name CYP2C8
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4446

Predictions


Id Partner name Gene Name Score
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 1.6518
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 1.6518
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 1.6518
1588 Multidrug resistance protein 1 ABCB1 0.2622
6030 Cytochrome P450 2B6 CYP2B6 0.2358
4118 Cytochrome P450 3A5 CYP3A5 0.2311
6024 Cytochrome P450 1A1 CYP1A1 0.1737
6107 Cytochrome P450 3A7 CYP3A7 0.1718
20 Prostaglandin G/H synthase 1 PTGS1 0.1469
587 Serum albumin ALB 0.1208
6106 Cytochrome P450 2C18 CYP2C18 0.0927
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0898
492 Histamine H1 receptor HRH1 0.0851
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0775
290 Prostaglandin G/H synthase 2 PTGS2 0.0773
824 Sodium-dependent serotonin transporter SLC6A4 0.0713
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0702
3811 Cytochrome P450 19A1 CYP19A1 0.0651
1729 Solute carrier family 22 member 6 SLC22A6 0.0628
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0612
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0607
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0587
502 5-hydroxytryptamine 2A receptor HTR2A 0.058
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.057
831 D(2) dopamine receptor DRD2 0.0547
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0543
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0522
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0521
556 Alpha-1A adrenergic receptor ADRA1A 0.0515
1898 Cytochrome P450 1B1 CYP1B1 0.0506
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0489
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0483
862 Multidrug resistance-associated protein 1 ABCC1 0.048
766 Beta-2 adrenergic receptor ADRB2 0.0465
6145 Solute carrier family 22 member 1 SLC22A1 0.0456
891 Dihydropteroate synthase folP 0.0439
5359 Dihydropteroate synthase folP 0.0439
7175 Dihydropteroate synthase sulI 0.0439
6144 Solute carrier family 22 member 2 SLC22A2 0.0434
590 5-hydroxytryptamine 2C receptor HTR2C 0.0416
713 Sodium-dependent dopamine transporter SLC6A3 0.0414
51 Muscarinic acetylcholine receptor M3 CHRM3 0.041
3941 Amine oxidase [flavin-containing] A MAOA 0.0409
318 Alpha-2A adrenergic receptor ADRA2A 0.0403
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0401
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0399
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0389
136 Estrogen receptor ESR1 0.0386
23 D(1A) dopamine receptor DRD1 0.0381
118 Organic cation/carnitine transporter 2 SLC22A5 0.0381
341 5-hydroxytryptamine 3 receptor HTR3A 0.0376
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0376
6103 Arylamine N-acetyltransferase 1 NAT1 0.0376
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0372
260 Cytochrome P450 51 ERG11 0.0372
761 Cytochrome P450 51 ERG11 0.0372
3163 Cytochrome P450 51 cyp51 0.0372
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.037
320 5-hydroxytryptamine 1A receptor HTR1A 0.0369
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0362
776 Bile salt export pump ABCB11 0.0356
193 Beta-1 adrenergic receptor ADRB1 0.0336
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0336
632 Alpha-1B adrenergic receptor ADRA1B 0.0332
4163 Potassium voltage-gated channel subfamily KQT member 4 KCNQ4 0.033
4164 Potassium voltage-gated channel subfamily KQT member 5 KCNQ5 0.033
6855 Enoyl-(Acyl-carrier-protein) reductase fabI 0.0328
6877 Enoyl-(Acyl-carrier-protein) reductase fabK 0.0328
847 Mu-type opioid receptor OPRM1 0.0323
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0321
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0316
731 HIV-1 protease HIV-1 protease 0.0314
2164 Multidrug resistance-associated protein 4 ABCC4 0.0314
3939 Amine oxidase [flavin-containing] B MAOB 0.0312
468 Cytochrome P450 4A11 CYP4A11 0.0311
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0309
871 Glucocorticoid receptor NR3C1 0.0305
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0304
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0296
465 Calmodulin CALM1 0.0291
6142 Solute carrier family 22 member 8 SLC22A8 0.0286
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0286
885 5-hydroxytryptamine 1B receptor HTR1B 0.0283
6031 Cytochrome P450 3A43 CYP3A43 0.0282
467 Delta-type opioid receptor OPRD1 0.028
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0279
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0278
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0274
6143 Solute carrier family 22 member 7 SLC22A7 0.0274
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0272
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0271
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0271
696 Kappa-type opioid receptor OPRK1 0.027
817 DNA topoisomerase 2-alpha TOP2A 0.0266
5325 2,4-dienoyl-CoA reductase, mitochondrial DECR1 0.0261
36 Insulin receptor INSR 0.0258
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0256
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0255
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0254
6147 Solute carrier family 22 member 3 SLC22A3 0.0254
3601 Dihydropteroate synthase 1 folP1 0.0251
3807 Dihydropteroate synthase 1 folP1 0.0251
3808 Dihydropteroate synthase 2 folP2 0.0251
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0247
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0246
638 D(3) dopamine receptor DRD3 0.0246
6014 Cytochrome P450 2A13 CYP2A13 0.0242
811 Translocator protein TSPO 0.0239
1757 Myeloperoxidase MPO 0.0235
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0235
725 5-hydroxytryptamine 1D receptor HTR1D 0.0233
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0232
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0229
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0228
833 Organic cation/carnitine transporter 1 SLC22A4 0.0222
789 Alpha-1D adrenergic receptor ADRA1D 0.0221
122 P2Y purinoceptor 12 P2RY12 0.0212
629 Alpha-2B adrenergic receptor ADRA2B 0.0209
1192 Sulfotransferase 1A1 SULT1A1 0.0208
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0207
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0206
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0204
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0203
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0198
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0198
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0198
442 Envelope glycoprotein gp41 0.0198
4859 Envelope glycoprotein env 0.0198
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0196
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0196
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0196
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0196
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0195
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0194
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0194
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0193
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0191
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0191
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0188
1050 Bile salt sulfotransferase SULT2A1 0.0188
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0186
1275 Estrogen sulfotransferase SULT1E1 0.0186
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0184
378 Alpha-2C adrenergic receptor ADRA2C 0.0183
432 D(4) dopamine receptor DRD4 0.0182
16 Adenosine A1 receptor ADORA1 0.018
6182 Cytochrome P450 2J2 CYP2J2 0.018
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0179
146 Androgen receptor AR 0.0176
777 Tumor necrosis factor TNF 0.0176
436 5-hydroxytryptamine 2B receptor HTR2B 0.0176
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0174
3923 Cholinesterase BCHE 0.0174
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0173
1024 Solute carrier family 22 member 11 SLC22A11 0.0173
70 Type-1 angiotensin II receptor AGTR1 0.017
482 Glycine receptor subunit alpha-1 GLRA1 0.017
94 5-hydroxytryptamine 4 receptor HTR4 0.017
477 DNA topoisomerase 4 subunit A parC 0.0165
886 DNA topoisomerase 4 subunit A parC 0.0165
6226 DNA topoisomerase 4 subunit A parC 0.0165
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0164
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0164
404 DNA gyrase subunit A gyrA 0.0163
6224 DNA gyrase subunit A gyrA 0.0163
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.016
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0159
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0159
2230 Catalase CAT 0.0159
3249 Catalase katA 0.0159
3625 Catalase katA 0.0159
4539 Catalase katA 0.0159
4941 Catalase katB 0.0159
6136 Multidrug resistance-associated protein 5 ABCC5 0.0156
380 Cytochrome P450 17A1 CYP17A1 0.0156
1178 Adenosine A2a receptor ADORA2A 0.0154
6220 Aryl hydrocarbon receptor AHR 0.0154
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0152
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.015
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.015
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0146
1010 Cytochrome P450 51A1 CYP51A1 0.0144
4604 Liver carboxylesterase 1 CES1 0.0139
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0139
275 Arachidonate 5-lipoxygenase ALOX5 0.0139
537 ATP synthase delta chain, mitochondrial ATP5D 0.0138
844 Epidermal growth factor receptor EGFR 0.0137
705 Glutamate receptor 1 GRIA1 0.0137
716 5-hydroxytryptamine 7 receptor HTR7 0.0136
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0136
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0135
869 Estrogen receptor beta ESR2 0.0133
614 Progesterone receptor PGR 0.0133
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0132
6141 Sodium/bile acid cotransporter SLC10A1 0.0131
365 Dihydrofolate reductase DHFR 0.0131
2381 Dihydrofolate reductase DFR1 0.0131
2833 Dihydrofolate reductase Not Available 0.0131
2931 Dihydrofolate reductase folA 0.0131
3544 Dihydrofolate reductase folA 0.0131
3682 Dihydrofolate reductase folA 0.0131
6642 Dihydrofolate reductase folA 0.0131
6756 Dihydrofolate reductase dfrA 0.0131
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0131
4116 Dihydropteroate synthetase Not Available 0.0131
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.013
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.013
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0129
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0129
6148 Multidrug resistance-associated protein 7 ABCC10 0.0128
124 Histamine H2 receptor HRH2 0.0128
504 Mast/stem cell growth factor receptor KIT 0.0127
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0125
232 Corticosteroid-binding globulin SERPINA6 0.0125
373 Transthyretin TTR 0.0124
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0124
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0123
571 Melatonin receptor type 1A MTNR1A 0.0122
362 Melatonin receptor type 1B MTNR1B 0.0122
921 Glutamate receptor 2 GRIA2 0.012
3947 Xanthine dehydrogenase/oxidase XDH 0.012
295 Carbonic anhydrase 1 CA1 0.0119
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0118
251 Alcohol dehydrogenase 1A ADH1A 0.0118
163 D(1B) dopamine receptor DRD5 0.0118
3810 Catechol O-methyltransferase COMT 0.0118
4122 Histone deacetylase 2 HDAC2 0.0117
592 Carbonic anhydrase 4 CA4 0.0116
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0116
474 Acetylcholinesterase ACHE 0.0113
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.0113
444 Alcohol dehydrogenase 1B ADH1B 0.0112
161 Tubulin beta chain TUBB 0.0111
312 Tubulin beta chain TUB2 0.0111
6137 Multidrug resistance-associated protein 6 ABCC6 0.0111
407 Vascular endothelial growth factor receptor 2 KDR 0.0111
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0109
613 Atrial natriuretic peptide receptor A NPR1 0.0106
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0105
818 50S ribosomal protein L10 rplJ 0.0102
4237 50S ribosomal protein L22 rplV 0.01
26 Vascular endothelial growth factor receptor 3 FLT4 0.0099
958 Insulin-like growth factor 1 receptor IGF1R 0.0097
563 Thyroid peroxidase TPO 0.0097
528 5-hydroxytryptamine 1E receptor HTR1E 0.0096
29 Tubulin beta-1 chain TUBB1 0.0096
49 Endothelin B receptor EDNRB 0.0096
1256 5-hydroxytryptamine 6 receptor HTR6 0.0095
32 Vascular endothelial growth factor receptor 1 FLT1 0.0094
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0094
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0094
4120 NADPH--cytochrome P450 reductase POR 0.0093
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0092
517 Alcohol dehydrogenase 1C ADH1C 0.0092
1656 CYP2B protein CYP2B 0.0091
952 Dipeptidyl peptidase 4 DPP4 0.0091
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0091
578 Endothelin-1 receptor EDNRA 0.009
756 Sex hormone-binding globulin SHBG 0.009
228 Beta platelet-derived growth factor receptor PDGFRB 0.0089
427 Substance-P receptor TACR1 0.0089
3932 Glutathione S-transferase A2 GSTA2 0.0089
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0088
4238 50S ribosomal protein L4 rplD 0.0088
5578 50S ribosomal protein L4 rplD 0.0088
6173 50S ribosomal protein L4 rplD 0.0088
6219 50S ribosomal protein L4 rplD 0.0088
6020 Aldehyde oxidase AOX1 0.0088
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0088
131 Synaptic vesicular amine transporter SLC18A2 0.0088
68 Cannabinoid receptor 1 CNR1 0.0087
2298 Cytochrome P450-cam camC 0.0087
357 Carbonic anhydrase 2 CA2 0.0087
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0085
6126 Carbonic anhydrase 7 CA7 0.0084
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0084
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0082
565 Extracellular calcium-sensing receptor CASR 0.008
158 Sodium channel protein type 1 subunit alpha SCN1A 0.008
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.008
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0079
511 5-hydroxytryptamine 1F receptor HTR1F 0.0079
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0079
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0079
173 Toll-like receptor 7 TLR7 0.0079
737 Mineralocorticoid receptor NR3C2 0.0079
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0077
284 DNA-directed RNA polymerase beta chain rpoB 0.0077
5773 DNA-directed RNA polymerase beta chain rpoB 0.0077
183 Vascular endothelial growth factor A VEGFA 0.0077
88 Retinoic acid receptor RXR-beta RXRB 0.0077
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0076
823 Fibroblast growth factor receptor 2 FGFR2 0.0076
6174 50S ribosomal protein L32 rpmF 0.0075
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0075
7 Nitric oxide synthase, inducible NOS2 0.0075
1541 Metalloproteinase mmp20 0.0074
814 Ryanodine receptor 1 RYR1 0.0074
4148 Serine/threonine-protein kinase mTOR MTOR 0.0073
153 Dopamine beta-hydroxylase DBH 0.0073
2183 Fatty acid-binding protein, adipocyte FABP4 0.0072
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0072
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0072
6432 Transporter snf 0.0072
738 Monocarboxylate transporter 1 SLC16A1 0.0071
790 DNA polymerase subunit alpha B POLA2 0.0071
24 Thymidylate synthase TMP1 0.0071
359 Thymidylate synthase TYMS 0.0071
2626 Thymidylate synthase thyA 0.0071
2729 Thymidylate synthase thyA 0.0071
5352 Thymidylate synthase THYA 0.0071
4203 Histamine N-methyltransferase HNMT 0.0071
6085 Fatty acid-binding protein, intestinal FABP2 0.007
84 Nuclear receptor 0B1 NR0B1 0.0069
634 Squalene monooxygenase SQLE 0.0068
7196 Squalene monooxygenase ERG1 0.0068
3809 Estrogen-related receptor gamma ESRRG 0.0068
1629 Transcription factor AP-1 JUN 0.0068
2112 Toll-like receptor 9 TLR9 0.0068
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0067
1636 Trace amine-associated receptor 1 TAAR1 0.0067
4954 Soluble cytochrome b558 Not Available 0.0067
4905 Cytochrome c2 Not Available 0.0067
4939 Cytochrome c2 cycA 0.0067
4964 Cytochrome c2 cycA 0.0067
4979 Cytochrome c2 cycA 0.0067
6673 Cytochrome c2 cycA 0.0067
4916 Cyanoglobin glbN 0.0067
4936 Cytochrome c2 iso-2 Not Available 0.0067
4915 Cytochrome c-550 psbV 0.0067
4959 Cytochrome c-550 psbV 0.0067
5216 Cytochrome c-550 psbV 0.0067
4925 Cytochrome c-type protein SHP shp 0.0067
4934 Cytochrome c-551 nirM 0.0067
5218 Cytochrome c-551 nirM 0.0067
4907 Cytochrome c-L moxG 0.0066
6865 Cytochrome c-L moxG 0.0066
4998 Hemoglobin-like protein yjbI yjbI 0.0066
4947 Bacterial hemoglobin vhb 0.0066
4975 Cytochrome c-556 RPA3973 0.0066
4984 Neuroglobin NGB 0.0066
4942 Diheme cytochrome c napB napB 0.0066
4943 Cytochrome c6 petJ 0.0066
4910 Cytoglobin CYGB 0.0066
4981 Iron-starvation protein PigA pigA 0.0066
4937 Cytochrome oxidase subunit II rcoxA 0.0066
4909 CooA protein cooA 0.0066
4994 Hemoglobin-like protein HbO glbO 0.0066
5000 HemO hemO 0.0066
4935 Cytochrome c-554 cycA1 0.0066
4971 Nonaheme cytochrome c hmcA 0.0066
644 Heme oxygenase 2 HMOX2 0.0066
4982 Heme oxygenase 2 pbsA2 0.0066
4960 Putative cytochrome P450-family protein SCO7417 0.0066
4931 Cytochrome P450 167A1 CYP167A1 0.0066
4961 Hemophore HasA hasA 0.0066
4904 Cytochrome c family protein GSU1996 0.0066
4989 Cytochrome c551 peroxidase ccp 0.0066
5222 Cytochrome c551 peroxidase ccpA 0.0066
4976 Apocytochrome f petA 0.0066
6407 Apocytochrome f petA 0.0066
4922 Cytochrome c, putative SO_4144 0.0066
4999 Cytochrome P450 165B3 CYP165B3 0.0066
4764 Cytochrome P450 165C4 CYP165C4 0.0066
4972 P450cin cinA 0.0066
4926 Heme-based aerotactic transducer hemAT hemAT 0.0066
4993 Hydroxylamine oxidoreductase hao1 0.0066
4952 Catalase/peroxidase katA 0.0066
3093 Catalase HPII katE 0.0066
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0066
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0066
4903 Methyl-accepting chemotaxis protein Tar4 0.0066
4311 tRNA TRDMT1 0.0066
4325 tRNA trmD 0.0066
4328 tRNA trmD 0.0066
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0066
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0066
273 Apoptosis regulator Bcl-2 BCL2 0.0065
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0065
904 Glutathione S-transferase P GSTP1 0.0064
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0063
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0063
1648 Elastin ELN 0.0063
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0063
3937 Fatty-acid amide hydrolase FAAH 0.0063
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0063
3917 Methylenetetrahydrofolate reductase MTHFR 0.0063
133 Dihydropterate synthase sulI 0.0063
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0062
1618 High affinity nerve growth factor receptor NTRK1 0.0062
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0062
106 Cannabinoid receptor 2 CNR2 0.0062
358 Cystathionine beta-synthase CBS 0.0061
780 Retinoic acid receptor RXR-gamma RXRG 0.0061
856 Vitamin D3 receptor VDR 0.006
239 Coagulation factor X F10 0.006
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0059
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0058
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0058
6146 High affinity copper uptake protein 1 SLC31A1 0.0058
5880 Thrombopoietin receptor MPL 0.0058
6138 Multidrug resistance protein 3 ABCB4 0.0058
208 DNA-directed RNA polymerase beta' chain rpoC 0.0058
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0058
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0058
174 Sigma 1-type opioid receptor SIGMAR1 0.0057
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0057
2539 Tubulin alpha-1 chain TUBA4A 0.0057
6044 Serum paraoxonase/lactonase 3 PON3 0.0057
1483 Membrane copper amine oxidase AOC3 0.0057
4948 Cytochrome c-553 Not Available 0.0056
4923 Cytochrome c3 DvMF_2499 0.0056
4945 Cytochrome c3 Not Available 0.0056
4949 Cytochrome c3 DVU_3171 0.0056
4968 Cytochrome c3 cytc3 0.0056
4997 Cytochrome c3 SO_2727 0.0056
5219 Cytochrome c3 cyd 0.0056
976 Platelet glycoprotein IX GP9 0.0056
4902 Nine-heme cytochrome c Ddes_2038 0.0056
3189 High-molecular-weight cytochrome c hmcA 0.0056
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0056
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0056
1517 Beta-3 adrenergic receptor ADRB3 0.0055
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0055
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0055
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0055
6506 Stathmin-4 STMN4 0.0055
5300 Antigen peptide transporter 1 TAP1 0.0055
558 Solute carrier family 12 member 1 SLC12A1 0.0054
3221 Cytochrome c4 cc4 0.0053
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0053
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0053
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0053
4920 Peroxidase/catalase katG 0.0053
390 Adenosine A3 receptor ADORA3 0.0053
5998 Toll-like receptor 8 TLR8 0.0053
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0053
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0052
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0052
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0052
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0052
54 Prothrombin F2 0.0052
473 L-lactate dehydrogenase A chain LDHA 0.0052
712 Tubulin alpha chain TUB1 0.0052
469 Annexin A1 ANXA1 0.0052
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0052
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0052
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0052
3090 Chitosanase csn 0.0052
4149 Nuclear factor NF-kappa-B p100 subunit NFKB2 0.0052
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0052
164 Histamine H4 receptor HRH4 0.0052
162 Retinoic acid receptor gamma-1 RARG 0.0052
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0051
3823 Cytokine receptor common gamma chain IL2RG 0.0051
2915 Sensor protein fixL fixL 0.0051
4944 Sensor protein fixL fixL 0.0051
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0051
319 Opioid receptor, sigma 1 OPRS1 0.0051
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0051
581 Cytochrome P450 2R1 CYP2R1 0.005
2119 Cytochrome b5 CYB5A 0.005
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.005
4988 Sulfite oxidase, mitochondrial SUOX 0.005
4037 Hypothetical protein GPX1 0.005
4297 Hypothetical protein SP_1951 0.005
4521 Hypothetical protein BC_2969 0.005
4540 Hypothetical protein TM_1070 0.005
4555 Hypothetical protein MT1739 0.005
4569 Hypothetical protein mshD 0.005
4578 Hypothetical protein PA3270 0.005
4747 Hypothetical protein PA3967 0.005
5177 Hypothetical protein TM_0096 0.005
5194 Hypothetical protein PA1204 0.005
5240 Hypothetical protein Rv2991 0.005
5370 Hypothetical protein TM_1158 0.005
5710 Hypothetical protein Tb927.5.1360 0.005
4385 Cytochrome c' Not Available 0.005
4967 Cytochrome c' cycA 0.005
5038 Cytochrome c' Not Available 0.005
5223 Cytochrome c' cycP 0.005
3570 Cytochrome P450 152A1 cypC 0.005
4990 PpcA ppcA 0.005
3375 Acidic cytochrome c3 Not Available 0.005
4813 Heme oxygenase hmuO 0.005
5769 Heme oxygenase Not Available 0.005
4289 Cytochrome P450 TT_P0059 0.005
6262 Cytochrome P450 staP 0.005
4992 Cytochrome c peroxidase Not Available 0.005
5251 Carbonyl reductase [NADPH] 1 CBR1 0.005
714 Glutathione reductase, mitochondrial GSR 0.005
291 Nitric-oxide synthase, endothelial NOS3 0.0049
6766 O-GlcNAcase BT_4395 BT_4395 0.0049
4386 Hemoglobin-like protein HbN glbN 0.0049
6043 Putative G-protein coupled receptor 44 GPR44 0.0049
3404 Exotoxin A eta 0.0049
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0049
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0049
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0048
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0048
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0047
4217 Telomerase reverse transcriptase TERT 0.0047
723 Cytosolic phospholipase A2 PLA2G4A 0.0047
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0047
1253 Interferon gamma IFNG 0.0046
4228 Keratin, type II cytoskeletal 7 KRT7 0.0046
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0046
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0046
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0046
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0046
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0046
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0046
992 Protein tyrosine kinase 2 beta PTK2B 0.0045
527 Prostacyclin receptor PTGIR 0.0045
3086 Plasmepsin-2 Not Available 0.0045
3856 Fibroblast growth factor receptor 3 FGFR3 0.0045
3957 Adenosine deaminase ADA 0.0045
3411 Cytochrome P450 121 cyp121 0.0045
724 Interleukin-2 receptor alpha chain IL2RA 0.0045
717 Interleukin-2 receptor subunit beta IL2RB 0.0045
2178 Metabotropic glutamate receptor 5 GRM5 0.0045
3670 Soluble cytochrome b562 precursor cybC 0.0045
65 Matrix metalloproteinase-9 Not Available 0.0044
3639 Thymidine phosphorylase deoA 0.0044
3936 Thymidine phosphorylase TYMP 0.0044
1196 Complement decay-accelerating factor CD55 0.0044
2617 Nitric oxide synthase oxygenase nos 0.0044
2701 Nitric oxide synthase oxygenase nos 0.0044
3291 Cytochrome c-552 cycA 0.0044
4927 Cytochrome c-552 nrfA 0.0044
4938 Cytochrome c-552 cycA 0.0044
4953 Cytochrome c-552 nrfA 0.0044
5217 Cytochrome c-552 cycM 0.0044
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0044
130 Prostacyclin synthase PTGIS 0.0044
3102 Flavohemoprotein hmp 0.0044
4969 Flavohemoprotein hmp 0.0044
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0043
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0043
4103 Proteasome subunit beta type 2 PSMB2 0.0043
4226 Uridine phosphorylase 2 UPP2 0.0043
4102 Proteasome subunit beta type 5 PSMB5 0.0043
4101 Proteasome subunit beta type 1 PSMB1 0.0043
165 FL cytokine receptor FLT3 0.0043
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0042
5934 Cytochrome P450 26A1 CYP26A1 0.0042
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0041
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0041
2449 Tubulin alpha-3 chain TUBA1A 0.0041
459 Retinoic acid receptor RXR-alpha RXRA 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
400 Coagulation factor IX F9 0.004
5461 Coagulation factor IX F9 0.004
2972 6-deoxyerythronolide B hydroxylase eryF 0.004
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.004
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.004
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.004
3913 Glutamic acid decarboxylase GAD65 0.004
268 Adenosine A2b receptor ADORA2B 0.004
908 Glutathione S-transferase theta-1 GSTT1 0.004
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0039
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0039
4225 Uridine phosphorylase 1 UPP1 0.0039
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0039
2290 ADP-ribosyl cyclase 2 BST1 0.0039
1507 Cytochrome c CYCS 0.0039
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0038
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0038
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0038
2808 Chloramphenicol acetyltransferase 3 cat3 0.0038
4608 Putative cytochrome P450 SCO1207 0.0038
4963 Putative cytochrome P450 SCO2884 0.0038
6254 Putative cytochrome P450 SCO6998 0.0038
605 Fumarate reductase flavoprotein subunit frdA 0.0038
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0038
3673 Fumarate reductase flavoprotein subunit fccA 0.0038
4912 Fumarate reductase flavoprotein subunit ifcA 0.0038
6549 Fumarate reductase flavoprotein subunit frdA 0.0038
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0038
569 Retinal dehydrogenase 2 ALDH1A2 0.0038
1992 Vitamin D-binding protein GC 0.0038
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0038
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0038
85 Growth hormone receptor GHR 0.0038
1374 Natriuretic peptides B NPPB 0.0038
2981 Phospholipase A2, membrane associated PLA2G2A 0.0038
1827 Gap junction alpha-1 protein GJA1 0.0037
1908 Vascular cell adhesion protein 1 VCAM1 0.0037
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0037
1360 Sphingomyelin phosphodiesterase SMPD1 0.0037
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0037
604 Vitamin K-dependent protein Z PROZ 0.0037
1039 Histone deacetylase 9 HDAC9 0.0037
2320 Thymidine kinase, cytosolic TK1 0.0037
413 Amidophosphoribosyltransferase PPAT 0.0037
2515 Amidophosphoribosyltransferase purF 0.0037
3714 Amidophosphoribosyltransferase purF 0.0037
611 Retinal dehydrogenase 1 ALDH1A1 0.0036
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0036
5787 Angiopoietin-1 receptor TEK 0.0036
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0036
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0036
633 Penicillin-binding proteins 1A/1B pbpA 0.0036
543 Penicillin-binding protein 1B mrcB 0.0035
6186 Penicillin-binding protein 1B ponB 0.0035
6822 Penicillin-binding protein 1b pbp1b 0.0035
6844 Penicillin-binding protein 1b pbp1b 0.0035
1630 Integrin beta-2 ITGB2 0.0035
185 Vasopressin V1a receptor AVPR1A 0.0035
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0035
2417 Chloramphenicol acetyltransferase cat 0.0035
3278 Chloramphenicol acetyltransferase cat 0.0035
117 Sterol O-acyltransferase 1 SOAT1 0.0035
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0035
1268 Neuropeptide S receptor NPSR1 0.0035
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0035
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0035
2810 Dr hemagglutinin structural subunit draA 0.0035
159 Penicillin-binding protein 2B penA 0.0035
6121 Penicillin-binding protein 2B penA 0.0035
939 50S ribosomal protein L3 rplC 0.0035
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0034
322 Vasopressin V2 receptor AVPR2 0.0034
719 Retinoic acid receptor responder protein 1 RARRES1 0.0034
770 Retinoic acid-induced protein 3 GPRC5A 0.0034
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0034
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0034
693 Hemoglobin subunit beta HBB 0.0034
2499 Tubulin beta-2C chain TUBB2C 0.0034
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0034
1245 Vitamin K-dependent protein S PROS1 0.0034
422 Vitamin K-dependent protein C PROC 0.0034
820 Glycine receptor subunit alpha-2 GLRA2 0.0034
33 Cystine/glutamate transporter SLC7A11 0.0033
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0033
735 Alanine aminotransferase 1 GPT 0.0033
3904 Alanine aminotransferase 2 GPT2 0.0033
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0033
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0033
229 Retinoic acid receptor beta RARB 0.0033
6268 Hydroxyacid oxidase 1 HAO1 0.0033
730 Retinoic acid receptor alpha RARA 0.0032
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0032
4192 DNA topoisomerase 2-beta TOP2B 0.0032
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0032
810 Heme oxygenase 1 HMOX1 0.0032
3391 Heme oxygenase 1 pbsA1 0.0032
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0032
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0032
6073 Potassium channel subfamily K member 9 KCNK9 0.0031
6072 Potassium channel subfamily K member 3 KCNK3 0.0031
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
2207 Rhodopsin RHO 0.0031
63 Malate dehydrogenase mdh 0.0031
2329 Malate dehydrogenase mdh 0.0031
3445 Malate dehydrogenase mdh 0.0031
4420 Malate dehydrogenase mdh 0.0031
4438 Malate dehydrogenase mdh 0.0031
751 Potassium channel subfamily K member 6 KCNK6 0.0031
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0031
1227 Cytochrome b MT-CYB 0.0031
6386 Cytochrome b petB 0.0031
6937 Cytochrome b MT-CYB 0.0031
674 Dihydroorotate dehydrogenase homolog, mitochondrial PFF0160c 0.0031
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0031
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0031
2578 Tubulin beta-3 chain TUBB3 0.003
6149 Solute carrier family 22 member 10 SLC22A10 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
76 Nitric-oxide synthase, brain NOS1 0.003
448 Vitamin K-dependent gamma-carboxylase GGCX 0.003
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.003
512 DNA-directed RNA polymerase alpha chain rpoA 0.0029
5772 DNA-directed RNA polymerase alpha chain rpoA 0.0029
172 Potassium channel subfamily K member 1 KCNK1 0.0028
330 Spermidine synthase SRM 0.0028
3038 Spermidine synthase speE 0.0028
327 Glutathione reductase gor 0.0028
5110 Glutathione reductase GR2 0.0028
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0028
1200 AMBP protein AMBP 0.0028
3866 Serum amyloid A protein SAA1 0.0028
1932 Apolipoprotein E APOE 0.0028
798 Osteocalcin BGLAP 0.0028
1852 Microtubule-associated protein 2 MAP2 0.0028
1144 Hepatocyte growth factor receptor MET 0.0027
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
2159 Quinone oxidoreductase CRYZ 0.0027
572 Integrin alpha-L ITGAL 0.0027
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0027
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0027
3849 Insulin-like growth factor-binding protein 7 IGFBP7 0.0027
2009 Protein NOV homolog NOV 0.0027
3847 Neuroendocrine convertase 2 PCSK2 0.0027
1949 Carboxypeptidase E CPE 0.0027
3850 Synaptotagmin-like protein 4 SYTL4 0.0027
3848 Neuroendocrine convertase 1 PCSK1 0.0027
3846 Retinoblastoma-associated protein RB1 0.0027
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0027
1262 Corticotropin-lipotropin POMC 0.0027
936 Ephrin type-A receptor 2 EPHA2 0.0026
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0026
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0025
6033 High affinity interleukin-8 receptor A CXCR1 0.0025
3830 Calreticulin CALR 0.0025
369 Coagulation factor VII F7 0.0025
768 FK506-binding protein 1A FKBP1A 0.0025
1864 RET proto-oncogene RET 0.0025
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0024
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0024
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0024
334 S-adenosylmethionine synthetase isoform type-2 MAT2A 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
2300 Lysozyme E 0.0024
3633 Lysozyme R 0.0024
5597 Lysozyme 17 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
6070 Nischarin NISCH 0.0024
233 Potassium channel subfamily K member 2 KCNK2 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
4773 Deoxycytidine kinase DCK 0.0024
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0023
6034 Hydroxyindole O-methyltransferase ASMT 0.0023
6035 Nuclear receptor ROR-beta RORB 0.0023
6048 Troponin C, skeletal muscle TNNC2 0.0023
6036 Eosinophil peroxidase EPX 0.0023
896 Glutathione S-transferase Mu 1 GSTM1 0.0023
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0023
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0023
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0023
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0023
1830 5'-nucleotidase NT5E 0.0023
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.0023
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0023
1341 Histamine H3 receptor HRH3 0.0023
6131 Carbonic anhydrase 14 CA14 0.0023
113 S-adenosylmethionine decarboxylase proenzyme AMD1 0.0022
5798 Mitogen-activated protein kinase 11 MAPK11 0.0022
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0022
411 Glycine N-methyltransferase GNMT 0.0022
267 Plasminogen activator inhibitor 1 SERPINE1 0.0022
2155 Insulin-degrading enzyme IDE 0.0022
2232 Interleukin-5 IL5 0.0022
6824 Tyrosine-protein kinase Lyn LYN 0.0021
298 Renin REN 0.0021
1593 Mucin-2 MUC2 0.0021
6122 Carbonic anhydrase 3 CA3 0.0021
2091 Endoplasmin HSP90B1 0.0021
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.0021
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0021
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0021
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0021
828 Phenylalanine-4-hydroxylase PAH 0.0021
3109 Phenylalanine-4-hydroxylase phhA 0.0021
594 Thyroxine-binding globulin SERPINA7 0.002
765 Indoleamine 2,3-dioxygenase IDO1 0.002
3611 Cytidine deaminase cdd 0.002
3707 Cytidine deaminase cdd 0.002
4211 Cytidine deaminase CDA 0.002
2021 Thrombomodulin THBD 0.002
1820 Beta-nerve growth factor NGF 0.002
2236 Casein kinase II subunit alpha CSNK2A1 0.0019
6218 Pannexin-1 PANX1 0.0019
6221 Steroid hormone receptor ERR1 ESRRA 0.0019
3191 Histidinol dehydrogenase hisD 0.0019
5923 Microtubule-associated protein tau MAPT 0.0019
5924 Microtubule-associated protein 4 MAP4 0.0019
2216 Fibroblast growth factor receptor 4 FGFR4 0.0019
6163 Copper-transporting ATPase 2 ATP7B 0.0019
6165 Copper-transporting ATPase 1 ATP7A 0.0019
1291 cAMP response element-binding protein CREB1 0.0019
718 Folate receptor gamma FOLR3 0.0019
299 Folate receptor beta FOLR2 0.0019
804 Mitochondrial folate transporter/carrier SLC25A32 0.0019
760 Fibroblast growth factor 1 FGF1 0.0019
758 Thyroid hormone receptor alpha THRA 0.0019
3426 Glutamine synthetase glnA 0.0019
3987 Glutamine synthetase GLUL 0.0019
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0018
893 [Citrate [pro-3S]-lyase] ligase citC 0.0018
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0018
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0018
4210 Toll-like receptor 4 TLR4 0.0018
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0018
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0018
489 Monocarboxylate transporter 2 SLC16A7 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0018
683 Potassium transporter GK0582 0.0018
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0018
1123 Eosinophil cationic protein RNASE3 0.0018
6459 Glycodelin PAEP 0.0018
199 Monocarboxylate transporter 8 SLC16A2 0.0018
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0017
293 Gamma-glutamyl hydrolase GGH 0.0017
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0017
346 Thyroid hormone receptor beta-1 THRB 0.0017
144 Hemoglobin subunit alpha HBA1 0.0016
1243 Cathepsin D CTSD 0.0016
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0016
3233 Bile acid receptor NR1H4 0.0015
2853 14 kDa fatty acid-binding protein Not Available 0.0015
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0015
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0015
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0015
1714 Mitogen-activated protein kinase 3 MAPK3 0.0015
3844 HLA class II histocompatibility antigen, DQ(6) alpha chain HLA-DQA2 0.0015
1650 Heme carrier protein 1 SLC46A1 0.0015
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0015
4428 Redox-sensing transcriptional repressor rex rex 0.0015
4449 ADP-ribosyltransferase Not Available 0.0015
3381 Alcohol dehydrogenase Not Available 0.0015
4508 Alcohol dehydrogenase adhA 0.0015
2350 3-isopropylmalate dehydrogenase leuB 0.0015
3092 3-isopropylmalate dehydrogenase leuB 0.0015
4471 CDP-D-glucose-4,6-dehydratase ascB 0.0015
4495 3-oxoacyl-(Acyl carrier protein) reductase TM_1169 0.0015
4446 3alpha-hydroxysteroid dehydrogenase/carbonyl reductase Not Available 0.0015
4472 Glucose 1-dehydrogenase Not Available 0.0015
4423 Levodione reductase lvr 0.0015
4505 Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase bphB 0.0015
4443 Quinate/shikimate dehydrogenase ydiB 0.0015
4456 Inorganic polyphosphate/ATP-NAD kinase ppnK 0.0015
4500 L-lactate dehydrogenase 2 ldh2 0.0015
4447 Hypothetical protein yhfP yhfP 0.0015
4336 Glyceraldehyde 3-phosphate dehydrogenase Not Available 0.0015
4436 Glyceraldehyde 3-phosphate dehydrogenase tthHB8IM 0.0015
4414 Dehydrogenase TT_P0035 0.0015
4418 AGR_L_3209p AGR_L_3209 0.0015
4507 Alanine dehydrogenase ald 0.0015
4475 Hypothetical protein Rv0046c/MT0052 ino1 0.0015
4497 Benzyl alcohol dehydrogenase xylB 0.0015
3735 NAD(P) transhydrogenase subunit alpha part 1 pntAA 0.0015
4448 L-2-hydroxyisocaproate dehydrogenase Not Available 0.0015
4466 Glutathione-independent formaldehyde dehydrogenase fdhA 0.0015
4502 Formate dehydrogenase Not Available 0.0015
180 D-3-phosphoglycerate dehydrogenase PHGDH 0.0015
3726 D-3-phosphoglycerate dehydrogenase serA 0.0015
4291 D-3-phosphoglycerate dehydrogenase serA 0.0015
4487 Transcriptional regulator nadR nadR 0.0015
3729 Citrate synthase gltA 0.0015
4575 Citrate synthase cit 0.0015
4580 Citrate synthase gltA 0.0015
4435 L-aspartate dehydrogenase nadX 0.0015
4467 Alpha-glucosidase, putative TM_0752 0.0015
4455 Glycerol dehydrogenase gldA 0.0015
4506 Myo-inositol-1-phosphate synthase-related protein TM_1419 0.0015
4451 Vip2Ac vip2Ac 0.0015
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0014
6167 Organic solute transporter subunit beta OSTB 0.0014
6166 Organic solute transporter subunit alpha OSTA 0.0014
2599 Tyrosine-protein kinase HCK HCK 0.0014
6859 Protein S100-A4 S100A4 0.0014
1792 Tissue-type plasminogen activator PLAT 0.0014
3007 Carbonic anhydrase 12 CA12 0.0014
4205 Carbonic anhydrase 9 CA9 0.0014
1353 DNA topoisomerase 1 TOP1 0.0013
3552 DNA topoisomerase 1 topA 0.0013
244 Angiotensin-converting enzyme ACE 0.0013
6211 Tubulin epsilon chain TUBE1 0.0013
6212 Tubulin gamma-1 chain TUBG1 0.0013
6210 Tubulin delta chain TUBD1 0.0013
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0013
860 Nicotinamide N-methyltransferase NNMT 0.0013
5626 Nucleoside diphosphate kinase B NME2 0.0013
699 Nicotinic acid receptor 1 GPR109A 0.0013
928 Nicotinic acid receptor 2 GPR109B 0.0013
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0013
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
1199 GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1 ART1 0.0012
3615 Dihydrodipicolinate reductase dapB 0.0012
3618 Dihydrodipicolinate reductase dapB 0.0012
4462 Dihydrodipicolinate reductase dapB 0.0012
4503 NADPH-flavin oxidoreductase frp 0.0012
6698 Dehydrogenase/reductase SDR family member 4-like 2 DHRS4L2 0.0012
2591 Urocanate hydratase hutU 0.0012
2967 CDP-paratose 2-epimerase rfbE 0.0012
4482 UDP-galactose 4-epimerase galE 0.0012
2424 L-lactate dehydrogenase ldh 0.0012
2641 L-lactate dehydrogenase Not Available 0.0012
4437 L-lactate dehydrogenase ldh 0.0012
4442 L-lactate dehydrogenase ldh 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
126 D-lactate dehydrogenase dld 0.0012
3545 D-lactate dehydrogenase Not Available 0.0012
4510 D-lactate dehydrogenase ldhA 0.0012
4486 Phenol 2-hydroxylase component B pheA2 0.0012
3598 dTDP-4-dehydrorhamnose reductase rfbD 0.0012
4484 2,5-diketo-D-gluconic acid reductase A dkgA 0.0012
4427 TDP-glucose-4,6-dehydratase desIV 0.0012
3177 dTDP-glucose 4,6-dehydratase rfbB 0.0012
4499 dTDP-glucose 4,6-dehydratase rmlB 0.0012
2507 Diphtheria toxin Not Available 0.0012
4439 Ferredoxin reductase bphA4 0.0012
3671 7-alpha-hydroxysteroid dehydrogenase hdhA 0.0012
2831 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase Not Available 0.0012
3059 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase fabG3 0.0012
4477 Dihydrolipoyl dehydrogenase lpdV 0.0012
5077 Dihydrolipoyl dehydrogenase Not Available 0.0012
5117 Dihydrolipoyl dehydrogenase lpd 0.0012
3087 Nicotinate-nucleotide adenylyltransferase nadD 0.0012
4469 Nicotinate-nucleotide adenylyltransferase nadD 0.0012
3401 D-2-hydroxyisocaproate dehydrogenase Not Available 0.0012
4450 Iota toxin component Ia Not Available 0.0012
2336 2,3-diketo-L-gulonate reductase dlgD 0.0012
4498 Ornithine cyclodeaminase PP3533 0.0012
2018 Deoxyhypusine synthase DHPS 0.0012
2538 6-phospho-beta-glucosidase bglT bglT 0.0012
4496 C-terminal-binding protein 1 CTBP1 0.0012
2393 Maltose-6'-phosphate glucosidase glvA 0.0012
3081 3-dehydroquinate synthase aroB 0.0012
4509 Acetoin(diacetyl) reductase budC 0.0012
2881 Gamma-aminobutyraldehyde dehydrogenase prr 0.0012
2107 Microtubule-associated protein 1A MAP1A 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
1295 Fatty acid synthase FASN 0.0012
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0012
5433 UPF0230 protein TM_1468 TM_1468 0.0012
5431 Lipid binding protein Not Available 0.0012
3616 Fatty acid-binding protein, epidermal FABP5 0.0012
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0012
2683 Mono-ADP-ribosyltransferase C3 C3 0.0011
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0011
1063 Signal transducer and activator of transcription 5B STAT5B 0.0011
3296 Nicotinamide mononucleotide adenylyltransferase 1 NMNAT1 0.0011
4504 WbpP Not Available 0.0011
711 UDP-glucose 6-dehydrogenase UGDH 0.0011
3672 UDP-glucose 6-dehydrogenase hasB 0.0011
2799 Glyceraldehyde-3-phosphate dehydrogenase, glycosomal Not Available 0.0011
4318 Siroheme synthase cysG 0.0011
3367 GDP-mannose 6-dehydrogenase algD 0.0011
4440 NADH peroxidase npr 0.0011
4343 Alpha-glucosidase aglA 0.0011
3736 Glyceraldehyde-3-phosphate dehydrogenase A gapA 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
707 72 kDa type IV collagenase MMP2 0.0011
3333 Nicotinamide mononucleotide adenylyltransferase 3 NMNAT3 0.0011
3070 Adenosylhomocysteinase AHCY 0.0011
4424 Adenosylhomocysteinase PFE1050w 0.0011
6278 Adenosylhomocysteinase ahcY 0.0011
2434 NH(3)-dependent NAD(+) synthetase nadE 0.0011
2910 NH(3)-dependent NAD(+) synthetase nadE 0.0011
3217 NH(3)-dependent NAD(+) synthetase nadE 0.0011
1799 Glucose-6-phosphate 1-dehydrogenase G6PD 0.0011
2630 Glucose-6-phosphate 1-dehydrogenase zwf 0.0011
2826 Glucose--fructose oxidoreductase gfo 0.0011
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
816 Biliverdin reductase A BLVRA 0.001
316 4-trimethylaminobutyraldehyde dehydrogenase ALDH9A1 0.001
792 Aldehyde dehydrogenase, dimeric NADP-preferring ALDH3A1 0.001
579 Alcohol dehydrogenase class 4 mu/sigma chain ADH7 0.001
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.001
3238 Multidrug resistance protein mexA mexA 0.001
3709 Glycerol uptake facilitator protein glpF 0.001
3116 Bacterioferritin bfr 0.001
4906 Bacterioferritin bfr 0.001
4965 Bacterioferritin bfr 0.001
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.001
3173 Enolase eno 0.001
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.001
3393 TGF-beta receptor type-2 TGFBR2 0.001
4476 Mannitol dehydrogenase mtlD 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
5294 Nucleoside diphosphate kinase A NME1 0.001
328 Sorbitol dehydrogenase SORD 0.001
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.001
283 SEC14-like protein 2 SEC14L2 0.001
646 Malate dehydrogenase, cytoplasmic MDH1 0.001
350 3-hydroxyacyl-CoA dehydrogenase type-2 HSD17B10 0.001
178 NADH-cytochrome b5 reductase 3 CYB5R3 0.001
812 Dihydrolipoyl dehydrogenase, mitochondrial DLD 0.001
597 Dihydropteridine reductase QDPR 0.001
454 Peroxisomal multifunctional enzyme type 2 HSD17B4 0.001
396 Alcohol dehydrogenase 4 ADH4 0.001
363 NADP-dependent malic enzyme, mitochondrial ME3 0.001
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
6151 Monocarboxylate transporter 10 SLC16A10 0.001
4491 DNA ligase, NAD-dependent ligA 0.001
6837 Serine/threonine-protein kinase 17B STK17B 0.001
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.001
77 L-lactate dehydrogenase B chain LDHB 0.001
419 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial HADH 0.001
12 Alcohol dehydrogenase class 3 ADH5 0.001
2286 Isocitrate dehydrogenase [NADP] icd 0.001
2302 Isocitrate dehydrogenase [NADP] icd 0.001
2771 Isocitrate dehydrogenase [NADP] icd 0.001
2268 Cholesterol oxidase choB 0.0009
2822 Cholesterol oxidase choA 0.0009
997 Protein kinase C beta type PRKCB 0.0009
794 Glyceraldehyde-3-phosphate dehydrogenase, testis-specific GAPDHS 0.0009
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0009
599 Glyceraldehyde-3-phosphate dehydrogenase GAPDH 0.0009
4426 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0009
4454 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0009
4489 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0009
2211 Fatty acid-binding protein, heart FABP3 0.0009
2762 UDP-glucose 4-epimerase GALE 0.0009
3461 UDP-glucose 4-epimerase galE 0.0009
484 Tyrosine-protein kinase ABL2 ABL2 0.0009
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0009
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0009
166 NAD-dependent malic enzyme, mitochondrial ME2 0.0009
1048 Protein S100-A13 S100A13 0.0009
2226 Protein S100-A12 S100A12 0.0009
2852 DNA mismatch repair protein mutL mutL 0.0009
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0009
1770 Phospholipase C PLCL1 0.0009
2841 Phospholipase C plc 0.0009
6042 Prostaglandin reductase 2 PTGR2 0.0009
6677 Myelin P2 protein PMP2 0.0009
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0009
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0009
2283 Steroid Delta-isomerase ksi 0.0009
2920 Steroid Delta-isomerase ksi 0.0009
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.0009
1970 Protein kinase C alpha type PRKCA 0.0009
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0009
2132 Protein S100-B S100B 0.0009
2408 Tyrosine-protein kinase SYK SYK 0.0009
740 Argininosuccinate synthase ASS1 0.0009
865 Argininosuccinate synthase ASS1 0.0009
2680 Argininosuccinate synthase argG 0.0009
3194 Argininosuccinate synthase argG 0.0009
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0008
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0008
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0008
4692 A/G-specific adenine glycosylase mutY 0.0008
1867 Major prion protein PRNP 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
6599 HTH-type transcriptional regulator ttgR ttgR 0.0008
500 Monocarboxylate transporter 4 SLC16A3 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
1025 Aquaporin-1 AQP1 0.0008
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0007
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0007
461 Glycine receptor subunit alpha-3 GLRA3 0.0007
2802 Endoglucanase G celCCG 0.0007
822 Aldose reductase AKR1B1 0.0007
6316 ADP-ribosylation factor 1 ARF1 0.0007
6228 Nuclear receptor coactivator 1 NCOA1 0.0007
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0007
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0007
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0007
6207 30S ribosomal protein S14 rpsN 0.0007
6209 30S ribosomal protein S19 rpsS 0.0007
6712 30S ribosomal protein S19 rpsS 0.0007
6726 30S ribosomal protein S19 rpsS 0.0007
6134 Sodium channel subunit beta-3 SCN3B 0.0007
6133 Sodium channel subunit beta-2 SCN2B 0.0007
6135 Sodium channel subunit beta-4 SCN4B 0.0007
6241 Nuclear receptor coactivator 2 NCOA2 0.0007
6132 Sodium channel subunit beta-1 SCN1B 0.0007
6129 Carbonic anhydrase-related protein 11 CA11 0.0007
6127 Carbonic anhydrase-related protein CA8 0.0007
6128 Carbonic anhydrase-related protein 10 CA10 0.0007
645 Penicillin-binding protein 1A mrcA 0.0007
5805 Penicillin-binding protein 1A ponA 0.0007
6185 Penicillin-binding protein 1A mrcA 0.0007
6799 Penicillin-binding protein 1A pbpA 0.0007
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0007
1313 Lactoylglutathione lyase GLO1 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0007
125 DNA polymerase beta POLB 0.0007
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0007
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0006
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0006
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0006
6130 Carbonic anhydrase 13 CA13 0.0006
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0006
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0006
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0006
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0006
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0006
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0006
6168 Solute carrier family 22 member 16 SLC22A16 0.0006
1569 G1/S-specific cyclin-D1 CCND1 0.0006
1525 Heparin-binding growth factor 2 FGF2 0.0006
5221 Cytochrome c3, 13 kDa Not Available 0.0006
3152 Cytochrome c'' cycA 0.0006
5220 Split-Soret cytochrome c Ddes_2150 0.0006
3700 Cytochrome c-552 precursor nrfA 0.0006
1760 Aminopeptidase N ANPEP 0.0005
6843 Aminopeptidase N pepN 0.0005
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0005
3127 Nitrite reductase nirS 0.0005
3284 Nitrite reductase nirS 0.0005
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0005
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0004
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0004
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0004
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0004
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0004
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0004
3405 Quinohaemoprotein ethanol dehydrogenase type-1 qheDH 0.0004
1176 Mitogen-activated protein kinase 1 MAPK1 0.0004
2240 Cell division protein kinase 2 CDK2 0.0003
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