DT-Web: DB01132

Identification

Name

Pioglitazone

Accession Number

DB01132 (APRD00653)

Type

small molecule

Description

Pioglitazone is used for the treatment of diabetes mellitus type 2. Pioglitazone selectively stimulates nuclear receptor peroxisone proliferator-activated receptor gamma (PPAR-gamma). It modulates the transcription of the insulin-sensitive genes involved in the control of glucose and lipid metabolism in the lipidic, muscular tissues and in the liver.

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

356.439

Groups

approved

Monoisotopic Weight

356.119463206

Pharmacology

Indication

Treatment of Type II diabetes mellitus

Mechanism of action

Pioglitazone acts as an agonist at peroxisome proliferator activated receptors (PPAR) in target tissues for insulin action such as adipose tissue, skeletal muscle, and liver. Activation of PPAR-gamma receptors increases the transcription of insulin-responsive genes involved in the control of glucose production, transport, and utilization. In this way, pioglitazone both enhances tissue sensitivity to insulin and reduces hepatic gluconeogenesis. Thus, insulin resistance associated with type 2 diabetes mellitus is improved without an increase in insulin secretion by pancreatic ? cells.

Absorption

Following oral administration, in the fasting state, pioglitazone is first measurable in serum within 30 minutes, with peak concentrations observed within 2 hours. Food slightly delays the time to peak serum concentration to 3 to 4 hours, but does not alter the extent of absorption.

Protein binding

> 99%

Biotransformation

Hepatic

Route of elimination

Following oral administration, approximately 15% to 30% of the pioglitazone dose is recovered in the urine. Renal elimination of pioglitazone is negligible, and the drug is excreted primarily as metabolites and their conjugates. It is presumed that most of the oral dose is excreted into the bile either unchanged or as metabolites and eliminated in the feces.

Toxicity

Hypogycemia; LD₅₀=mg/kg (orally in rat)

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Colesevelam	Bile Acid Sequestrants may decrease the absorption of Antidiabetic Agents (Thiazolidinedione). Separate the dosing of bile acid sequestrants and thiazolidinediones by at least 2 hours. Monitor for reduced effects of the antidiabetic agents.
Gemfibrozil	Gemfibrozil may increase the effect and toxicity of pioglitazone.
Glucosamine	Possibly hyperglycemia
Ketoconazole	Ketoconazole increases the effect of pioglitazone
Mestranol	Possible loss of contraceptive effect
Norethindrone	Possible loss of contraceptive effect
Somatropin recombinant	Somatropin may antagonize the hypoglycemic effect of pioglitazone. Monitor for changes in fasting and postprandial blood sugars.
Tamoxifen	Pioglitazone may decrease the therapeutic effect of Tamoxifen by decreasing the production of active metabolites. Consider alternate therapy.
Tamsulosin	Pioglitazone, a CYP2D6 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP2D6 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Pioglitazone is initiated, discontinued, or dose changed.
Tramadol	Pioglitazone may decrease the effect of Tramadol by decreasing active metabolite production.
Tretinoin	The moderate CYP2C8 inhibitor, Pioglitazone, may decrease the metabolism and clearance of oral Tretinoin. Monitor for changes in Tretinoin effectiveness and adverse/toxic effects if Pioglitazone is initiated, discontinued to dose changed.

Food Interactions

Take without regard to meals. Food slightly delays absorption rate but extent of absorption is not affected.

Peroxisome proliferator-activated receptor gamma
Name	Peroxisome proliferator-activated receptor gamma
Gene Name	PPARG
Pharmacological action	yes
Actions	agonist
References	Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed Sugii S, Olson P, Sears DD, Saberi M, Atkins AR, Barish GD, Hong SH, Castro GL, Yin YQ, Nelson MC, Hsiao G, Greaves DR, Downes M, Yu RT, Olefsky JM, Evans RM: PPARgamma activation in adipocytes is sufficient for systemic insulin sensitization. Proc Natl Acad Sci U S A. 2009 Dec 29;106(52):22504-9. Epub 2009 Dec 16. - Pubmed Miyazaki Y, Mahankali A, Wajcberg E, Bajaj M, Mandarino LJ, DeFronzo RA: Effect of pioglitazone on circulating adipocytokine levels and insulin sensitivity in type 2 diabetic patients. J Clin Endocrinol Metab. 2004 Sep;89(9):4312-9. - Pubmed Lehmann JM, Moore LB, Smith-Oliver TA, Wilkison WO, Willson TM, Kliewer SA: An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma). J Biol Chem. 1995 Jun 2;270(22):12953-6. - Pubmed Spiegelman BM: PPAR-gamma: adipogenic regulator and thiazolidinedione receptor. Diabetes. 1998 Apr;47(4):507-14. - Pubmed Willson TM, Cobb JE, Cowan DJ, Wiethe RW, Correa ID, Prakash SR, Beck KD, Moore LB, Kliewer SA, Lehmann JM: The structure-activity relationship between peroxisome proliferator-activated receptor gamma agonism and the antihyperglycemic activity of thiazolidinediones. J Med Chem. 1996 Feb 2;39(3):665-8. - Pubmed
DTHybrid score	0.9711

Cytochrome P450 2C8
Name	Cytochrome P450 2C8
Gene Name	CYP2C8
Actions	substrate,inhibitor
References	Muschler E, Lal J, Jetter A, Rattay A, Zanger U, Zadoyan G, Fuhr U, Kirchheiner J: The role of human CYP2C8 and CYP2C9 variants in pioglitazone metabolism in vitro. Basic Clin Pharmacol Toxicol. 2009 Dec;105(6):374-9. Epub 2009 Jul 15. - Pubmed Jaakkola T, Laitila J, Neuvonen PJ, Backman JT: Pioglitazone is metabolised by CYP2C8 and CYP3A4 in vitro: potential for interactions with CYP2C8 inhibitors. Basic Clin Pharmacol Toxicol. 2006 Jul;99(1):44-51. - Pubmed Sahi J, Black CB, Hamilton GA, Zheng X, Jolley S, Rose KA, Gilbert D, LeCluyse EL, Sinz MW: Comparative effects of thiazolidinediones on in vitro P450 enzyme induction and inhibition. Drug Metab Dispos. 2003 Apr;31(4):439-46. - Pubmed Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.4038
Cytochrome P450 3A4
Name	Cytochrome P450 3A4
Gene Name	CYP3A4
Actions	substrate,inducer
References	Jaakkola T, Laitila J, Neuvonen PJ, Backman JT: Pioglitazone is metabolised by CYP2C8 and CYP3A4 in vitro: potential for interactions with CYP2C8 inhibitors. Basic Clin Pharmacol Toxicol. 2006 Jul;99(1):44-51. - Pubmed Sahi J, Black CB, Hamilton GA, Zheng X, Jolley S, Rose KA, Gilbert D, LeCluyse EL, Sinz MW: Comparative effects of thiazolidinediones on in vitro P450 enzyme induction and inhibition. Drug Metab Dispos. 2003 Apr;31(4):439-46. - Pubmed Nowak SN, Edwards DJ, Clarke A, Anderson GD, Jaber LA: Pioglitazone: effect on CYP3A4 activity. J Clin Pharmacol. 2002 Dec;42(12):1299-302. - Pubmed Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.6309
Prostaglandin G/H synthase 1
Name	Prostaglandin G/H synthase 1
Gene Name	PTGS1
Actions	substrate
References	Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
DTHybrid score	0.4974
Cytochrome P450 2C19
Name	Cytochrome P450 2C19
Gene Name	CYP2C19
Actions	inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.4371
Cytochrome P450 2C9
Name	Cytochrome P450 2C9
Gene Name	CYP2C9
Actions	substrate,inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.5534
Cytochrome P450 2D6
Name	Cytochrome P450 2D6
Gene Name	CYP2D6
Actions	inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.4621

Solute carrier organic anion transporter family member 1B3
Name	Solute carrier organic anion transporter family member 1B3
Gene Name	SLCO1B3
Actions	inhibitor
References	Nozawa T, Sugiura S, Nakajima M, Goto A, Yokoi T, Nezu J, Tsuji A, Tamai I: Involvement of organic anion transporting polypeptides in the transport of troglitazone sulfate: implications for understanding troglitazone hepatotoxicity. Drug Metab Dispos. 2004 Mar;32(3):291-4. - Pubmed
DTHybrid score	0.2255
Solute carrier organic anion transporter family member 1B1
Name	Solute carrier organic anion transporter family member 1B1
Gene Name	SLCO1B1
Actions	inhibitor
References	Nozawa T, Sugiura S, Nakajima M, Goto A, Yokoi T, Nezu J, Tsuji A, Tamai I: Involvement of organic anion transporting polypeptides in the transport of troglitazone sulfate: implications for understanding troglitazone hepatotoxicity. Drug Metab Dispos. 2004 Mar;32(3):291-4. - Pubmed
DTHybrid score	0.3303

Id	Partner name	Gene Name	Score
1588	Multidrug resistance protein 1	ABCB1	0.2722
4200	Cytochrome P450 1A2	CYP1A2	0.2556
4118	Cytochrome P450 3A5	CYP3A5	0.2173
290	Prostaglandin G/H synthase 2	PTGS2	0.1979
6030	Cytochrome P450 2B6	CYP2B6	0.1754
6107	Cytochrome P450 3A7	CYP3A7	0.1501
587	Serum albumin	ALB	0.1487
6013	Cytochrome P450 2E1	CYP2E1	0.1419
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.1272
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.1185
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.1144
6024	Cytochrome P450 1A1	CYP1A1	0.1075
1729	Solute carrier family 22 member 6	SLC22A6	0.1008
5718	Cytochrome P450 2A6	CYP2A6	0.0988
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0735
6142	Solute carrier family 22 member 8	SLC22A8	0.0714
492	Histamine H1 receptor	HRH1	0.0706
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0699
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0669
862	Multidrug resistance-associated protein 1	ABCC1	0.0664
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0655
6106	Cytochrome P450 2C18	CYP2C18	0.0631
2164	Multidrug resistance-associated protein 4	ABCC4	0.0614
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0611
70	Type-1 angiotensin II receptor	AGTR1	0.059
1181	Alpha-1-acid glycoprotein 1	ORM1	0.0587
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.056
824	Sodium-dependent serotonin transporter	SLC6A4	0.0549
275	Arachidonate 5-lipoxygenase	ALOX5	0.0536
6145	Solute carrier family 22 member 1	SLC22A1	0.0518
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0511
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0499
776	Bile salt export pump	ABCB11	0.0468
6228	Nuclear receptor coactivator 1	NCOA1	0.0462
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.0461
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0449
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0422
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0419
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0419
3811	Cytochrome P450 19A1	CYP19A1	0.0406
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0405
831	D(2) dopamine receptor	DRD2	0.0395
1898	Cytochrome P450 1B1	CYP1B1	0.0391
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0376
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0371
6143	Solute carrier family 22 member 7	SLC22A7	0.0371
556	Alpha-1A adrenergic receptor	ADRA1A	0.0369
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0362
1024	Solute carrier family 22 member 11	SLC22A11	0.0361
731	HIV-1 protease	HIV-1 protease	0.0353
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0348
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0345
6144	Solute carrier family 22 member 2	SLC22A2	0.0345
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0343
766	Beta-2 adrenergic receptor	ADRB2	0.0342
6141	Sodium/bile acid cotransporter	SLC10A1	0.0338
3587	Gastrotropin	FABP6	0.0333
459	Retinoic acid receptor RXR-alpha	RXRA	0.0332
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0318
136	Estrogen receptor	ESR1	0.0314
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0309
847	Mu-type opioid receptor	OPRM1	0.0306
713	Sodium-dependent dopamine transporter	SLC6A3	0.0306
118	Organic cation/carnitine transporter 2	SLC22A5	0.03
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0293
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0288
6241	Nuclear receptor coactivator 2	NCOA2	0.028
467	Delta-type opioid receptor	OPRD1	0.0272
193	Beta-1 adrenergic receptor	ADRB1	0.0264
373	Transthyretin	TTR	0.0261
696	Kappa-type opioid receptor	OPRK1	0.026
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0257
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0257
1757	Myeloperoxidase	MPO	0.0256
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0255
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0253
318	Alpha-2A adrenergic receptor	ADRA2A	0.0251
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0249
260	Cytochrome P450 51	ERG11	0.0249
761	Cytochrome P450 51	ERG11	0.0249
3163	Cytochrome P450 51	cyp51	0.0249
871	Glucocorticoid receptor	NR3C1	0.0247
23	D(1A) dopamine receptor	DRD1	0.0243
3941	Amine oxidase [flavin-containing] A	MAOA	0.0242
632	Alpha-1B adrenergic receptor	ADRA1B	0.0237
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0235
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0233
6148	Multidrug resistance-associated protein 7	ABCC10	0.0232
29	Tubulin beta-1 chain	TUBB1	0.0232
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0226
738	Monocarboxylate transporter 1	SLC16A1	0.0226
758	Thyroid hormone receptor alpha	THRA	0.022
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0215
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0214
6031	Cytochrome P450 3A43	CYP3A43	0.0212
450	Muscarinic acetylcholine receptor M4	CHRM4	0.021
468	Cytochrome P450 4A11	CYP4A11	0.0206
833	Organic cation/carnitine transporter 1	SLC22A4	0.0206
891	Dihydropteroate synthase	folP	0.0205
5359	Dihydropteroate synthase	folP	0.0205
7175	Dihydropteroate synthase	sulI	0.0205
4604	Liver carboxylesterase 1	CES1	0.0205
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0203
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0198
346	Thyroid hormone receptor beta-1	THRB	0.0196
594	Thyroxine-binding globulin	SERPINA7	0.0194
146	Androgen receptor	AR	0.0191
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0185
122	P2Y purinoceptor 12	P2RY12	0.0179
703	NADPH azoreductase	azr	0.0178
3923	Cholinesterase	BCHE	0.0178
6147	Solute carrier family 22 member 3	SLC22A3	0.0176
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0171
6182	Cytochrome P450 2J2	CYP2J2	0.0171
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.017
3939	Amine oxidase [flavin-containing] B	MAOB	0.0169
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0169
465	Calmodulin	CALM1	0.0168
6136	Multidrug resistance-associated protein 5	ABCC5	0.0164
638	D(3) dopamine receptor	DRD3	0.0163
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0159
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0159
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0158
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0157
33	Cystine/glutamate transporter	SLC7A11	0.0157
6102	Arylamine N-acetyltransferase 2	NAT2	0.0156
2539	Tubulin alpha-1 chain	TUBA4A	0.0156
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0155
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0155
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0153
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0153
789	Alpha-1D adrenergic receptor	ADRA1D	0.0153
811	Translocator protein	TSPO	0.0153
6085	Fatty acid-binding protein, intestinal	FABP2	0.0152
6167	Organic solute transporter subunit beta	OSTB	0.015
6166	Organic solute transporter subunit alpha	OSTA	0.015
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0148
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0146
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0145
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0144
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0142
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.014
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0138
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0137
407	Vascular endothelial growth factor receptor 2	KDR	0.0137
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0136
817	DNA topoisomerase 2-alpha	TOP2A	0.0136
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0136
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0135
504	Mast/stem cell growth factor receptor	KIT	0.0134
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0134
629	Alpha-2B adrenergic receptor	ADRA2B	0.0134
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0133
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0132
26	Vascular endothelial growth factor receptor 3	FLT4	0.0132
3312	Fatty acid-binding protein, brain	FABP7	0.013
365	Dihydrofolate reductase	DHFR	0.0128
2381	Dihydrofolate reductase	DFR1	0.0128
2833	Dihydrofolate reductase	Not Available	0.0128
2931	Dihydrofolate reductase	folA	0.0128
3544	Dihydrofolate reductase	folA	0.0128
3682	Dihydrofolate reductase	folA	0.0128
6642	Dihydrofolate reductase	folA	0.0128
6756	Dihydrofolate reductase	dfrA	0.0128
32	Vascular endothelial growth factor receptor 1	FLT1	0.0126
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0125
6137	Multidrug resistance-associated protein 6	ABCC6	0.0123
6220	Aryl hydrocarbon receptor	AHR	0.0121
273	Apoptosis regulator Bcl-2	BCL2	0.0121
614	Progesterone receptor	PGR	0.0121
432	D(4) dopamine receptor	DRD4	0.0121
952	Dipeptidyl peptidase 4	DPP4	0.0119
380	Cytochrome P450 17A1	CYP17A1	0.0117
199	Monocarboxylate transporter 8	SLC16A2	0.0115
1507	Cytochrome c	CYCS	0.0115
5880	Thrombopoietin receptor	MPL	0.0114
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0113
378	Alpha-2C adrenergic receptor	ADRA2C	0.0113
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0112
777	Tumor necrosis factor	TNF	0.011
844	Epidermal growth factor receptor	EGFR	0.0109
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0109
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0108
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0108
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0107
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0105
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0105
124	Histamine H2 receptor	HRH2	0.0103
756	Sex hormone-binding globulin	SHBG	0.0101
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.01
427	Substance-P receptor	TACR1	0.0099
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0098
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0098
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0098
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0098
869	Estrogen receptor beta	ESR2	0.0098
474	Acetylcholinesterase	ACHE	0.0098
4116	Dihydropteroate synthetase	Not Available	0.0097
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0097
716	5-hydroxytryptamine 7 receptor	HTR7	0.0097
161	Tubulin beta chain	TUBB	0.0097
312	Tubulin beta chain	TUB2	0.0097
592	Carbonic anhydrase 4	CA4	0.0097
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0096
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0096
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0096
49	Endothelin B receptor	EDNRB	0.0096
1852	Microtubule-associated protein 2	MAP2	0.0096
6014	Cytochrome P450 2A13	CYP2A13	0.0095
3809	Estrogen-related receptor gamma	ESRRG	0.0095
3810	Catechol O-methyltransferase	COMT	0.0094
94	5-hydroxytryptamine 4 receptor	HTR4	0.0094
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0094
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0094
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0094
1650	Heme carrier protein 1	SLC46A1	0.0094
5923	Microtubule-associated protein tau	MAPT	0.0093
5924	Microtubule-associated protein 4	MAP4	0.0093
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0093
232	Corticosteroid-binding globulin	SERPINA6	0.0093
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0091
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0091
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.009
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.009
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.009
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.009
578	Endothelin-1 receptor	EDNRA	0.009
6043	Putative G-protein coupled receptor 44	GPR44	0.009
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0089
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0088
558	Solute carrier family 12 member 1	SLC12A1	0.0088
4120	NADPH--cytochrome P450 reductase	POR	0.0088
295	Carbonic anhydrase 1	CA1	0.0087
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0086
163	D(1B) dopamine receptor	DRD5	0.0083
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0083
185	Vasopressin V1a receptor	AVPR1A	0.0082
68	Cannabinoid receptor 1	CNR1	0.0081
1648	Elastin	ELN	0.0081
6149	Solute carrier family 22 member 10	SLC22A10	0.0081
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0081
6151	Monocarboxylate transporter 10	SLC16A10	0.008
78	Acetyl-CoA acetyltransferase, mitochondrial	ACAT1	0.008
1629	Transcription factor AP-1	JUN	0.008
322	Vasopressin V2 receptor	AVPR2	0.008
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.0079
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0079
1010	Cytochrome P450 51A1	CYP51A1	0.0079
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0079
759	Free fatty acid receptor 1	FFAR1	0.0078
1818	Long-chain-fatty-acid--CoA ligase 3	ACSL3	0.0078
442	Envelope glycoprotein	gp41	0.0078
4859	Envelope glycoprotein	env	0.0078
24	Thymidylate synthase	TMP1	0.0077
359	Thymidylate synthase	TYMS	0.0077
2626	Thymidylate synthase	thyA	0.0077
2729	Thymidylate synthase	thyA	0.0077
5352	Thymidylate synthase	THYA	0.0077
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0077
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0077
563	Thyroid peroxidase	TPO	0.0076
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0075
284	DNA-directed RNA polymerase beta chain	rpoB	0.0075
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0075
1656	CYP2B protein	CYP2B	0.0075
1541	Metalloproteinase	mmp20	0.0074
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0074
6020	Aldehyde oxidase	AOX1	0.0073
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0073
183	Vascular endothelial growth factor A	VEGFA	0.0073
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0073
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0072
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0072
921	Glutamate receptor 2	GRIA2	0.0072
130	Prostacyclin synthase	PTGIS	0.0072
357	Carbonic anhydrase 2	CA2	0.0072
3947	Xanthine dehydrogenase/oxidase	XDH	0.0072
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0072
818	50S ribosomal protein L10	rplJ	0.0071
4203	Histamine N-methyltransferase	HNMT	0.0071
571	Melatonin receptor type 1A	MTNR1A	0.007
362	Melatonin receptor type 1B	MTNR1B	0.007
634	Squalene monooxygenase	SQLE	0.007
7196	Squalene monooxygenase	ERG1	0.007
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.007
823	Fibroblast growth factor receptor 2	FGFR2	0.007
1050	Bile salt sulfotransferase	SULT2A1	0.0069
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0069
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0068
4122	Histone deacetylase 2	HDAC2	0.0068
2112	Toll-like receptor 9	TLR9	0.0068
1053	BC269730_2	FADS1	0.0068
1395	Sodium/calcium exchanger 1	SLC8A1	0.0068
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0066
6103	Arylamine N-acetyltransferase 1	NAT1	0.0065
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0065
737	Mineralocorticoid receptor	NR3C2	0.0065
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0065
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0065
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0064
7	Nitric oxide synthase, inducible	NOS2	0.0064
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0064
267	Plasminogen activator inhibitor 1	SERPINE1	0.0064
1558	Transient receptor potential cation channel subfamily V member 1	TRPV1	0.0063
133	Dihydropterate synthase	sulI	0.0063
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0062
3856	Fibroblast growth factor receptor 3	FGFR3	0.0062
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0062
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0062
6221	Steroid hormone receptor ERR1	ESRRA	0.0061
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0061
1275	Estrogen sulfotransferase	SULT1E1	0.0061
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.006
856	Vitamin D3 receptor	VDR	0.006
518	Peroxidase/catalase T	katG	0.006
1630	Integrin beta-2	ITGB2	0.006
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.006
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.006
1256	5-hydroxytryptamine 6 receptor	HTR6	0.006
6126	Carbonic anhydrase 7	CA7	0.006
2981	Phospholipase A2, membrane associated	PLA2G2A	0.006
2021	Thrombomodulin	THBD	0.0059
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.0059
131	Synaptic vesicular amine transporter	SLC18A2	0.0059
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0058
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0058
1618	High affinity nerve growth factor receptor	NTRK1	0.0058
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0058
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0058
88	Retinoic acid receptor RXR-beta	RXRB	0.0057
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0057
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0057
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0056
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0056
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0056
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0055
6506	Stathmin-4	STMN4	0.0055
5300	Antigen peptide transporter 1	TAP1	0.0055
814	Ryanodine receptor 1	RYR1	0.0054
106	Cannabinoid receptor 2	CNR2	0.0054
3808	Dihydropteroate synthase 2	folP2	0.0054
3601	Dihydropteroate synthase 1	folP1	0.0054
3807	Dihydropteroate synthase 1	folP1	0.0054
768	FK506-binding protein 1A	FKBP1A	0.0054
850	Vasopressin V1b receptor	AVPR1B	0.0053
2853	14 kDa fatty acid-binding protein	Not Available	0.0053
1178	Adenosine A2a receptor	ADORA2A	0.0053
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0052
1192	Sulfotransferase 1A1	SULT1A1	0.0052
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.0051
4103	Proteasome subunit beta type 2	PSMB2	0.0051
4102	Proteasome subunit beta type 5	PSMB5	0.0051
4101	Proteasome subunit beta type 1	PSMB1	0.0051
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0051
6146	High affinity copper uptake protein 1	SLC31A1	0.0051
581	Cytochrome P450 2R1	CYP2R1	0.005
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.005
723	Cytosolic phospholipase A2	PLA2G4A	0.005
6500	Phospholipase A2	PLA2G1B	0.005
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.005
482	Glycine receptor subunit alpha-1	GLRA1	0.005
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0049
6033	High affinity interleukin-8 receptor A	CXCR1	0.0049
6044	Serum paraoxonase/lactonase 3	PON3	0.0049
173	Toll-like receptor 7	TLR7	0.0049
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0048
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0048
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0046
565	Extracellular calcium-sensing receptor	CASR	0.0046
4311	tRNA	TRDMT1	0.0046
4325	tRNA	trmD	0.0046
4328	tRNA	trmD	0.0046
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0046
174	Sigma 1-type opioid receptor	SIGMAR1	0.0046
572	Integrin alpha-L	ITGAL	0.0045
6012	Tryptophan 2,3-dioxygenase	TDO2	0.0045
527	Prostacyclin receptor	PTGIR	0.0045
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0045
3086	Plasmepsin-2	Not Available	0.0045
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0045
6174	50S ribosomal protein L32	rpmF	0.0045
16	Adenosine A1 receptor	ADORA1	0.0045
1196	Complement decay-accelerating factor	CD55	0.0044
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0044
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0044
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0043
1483	Membrane copper amine oxidase	AOC3	0.0043
1792	Tissue-type plasminogen activator	PLAT	0.0043
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0041
489	Monocarboxylate transporter 2	SLC16A7	0.0041
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0041
6042	Prostaglandin reductase 2	PTGR2	0.0041
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0041
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0041
3932	Glutathione S-transferase A2	GSTA2	0.004
780	Retinoic acid receptor RXR-gamma	RXRG	0.0039
6138	Multidrug resistance protein 3	ABCB4	0.0039
904	Glutathione S-transferase P	GSTP1	0.0039
4132	Chloride channel protein ClC-Ka	CLCNKA	0.0039
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.0039
153	Dopamine beta-hydroxylase	DBH	0.0039
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0039
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0039
1129	C-C chemokine receptor type 5	CCR5	0.0039
1525	Heparin-binding growth factor 2	FGF2	0.0039
2391	Ferrochelatase	hemH	0.0039
6502	Ferrochelatase	DKFZp686P18130	0.0039
1591	Ferrochelatase, mitochondrial	FECH	0.0039
4209	ATP-sensitive inward rectifier potassium channel 8	KCNJ8	0.0038
2808	Chloramphenicol acetyltransferase 3	cat3	0.0038
5818	Folate receptor alpha	FOLR1	0.0038
165	FL cytokine receptor	FLT3	0.0038
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0038
1992	Vitamin D-binding protein	GC	0.0038
85	Growth hormone receptor	GHR	0.0038
319	Opioid receptor, sigma 1	OPRS1	0.0037
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0037
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0037
1760	Aminopeptidase N	ANPEP	0.0037
6843	Aminopeptidase N	pepN	0.0037
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0037
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0037
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0037
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0037
54	Prothrombin	F2	0.0037
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0037
6432	Transporter	snf	0.0036
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0036
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0036
5787	Angiopoietin-1 receptor	TEK	0.0036
705	Glutamate receptor 1	GRIA1	0.0036
164	Histamine H4 receptor	HRH4	0.0036
633	Penicillin-binding proteins 1A/1B	pbpA	0.0036
117	Sterol O-acyltransferase 1	SOAT1	0.0036
976	Platelet glycoprotein IX	GP9	0.0036
84	Nuclear receptor 0B1	NR0B1	0.0035
4237	50S ribosomal protein L22	rplV	0.0035
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0035
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0035
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0035
2417	Chloramphenicol acetyltransferase	cat	0.0035
3278	Chloramphenicol acetyltransferase	cat	0.0035
2810	Dr hemagglutinin structural subunit	draA	0.0035
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0035
939	50S ribosomal protein L3	rplC	0.0035
469	Annexin A1	ANXA1	0.0035
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0034
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0034
239	Coagulation factor X	F10	0.0034
517	Alcohol dehydrogenase 1C	ADH1C	0.0034
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0034
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0034
6495	Cytochrome c oxidase subunit 7C, mitochondrial	COX7C	0.0033
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0033
6499	Cytochrome c oxidase polypeptide 7A1, mitochondrial	COX7A1	0.0033
6494	Cytochrome c oxidase subunit 7B, mitochondrial	COX7B	0.0033
6496	Cytochrome c oxidase subunit 8A, mitochondrial	COX8A	0.0033
6493	Cytochrome c oxidase subunit 6C	COX6C	0.0033
6491	Cytochrome c oxidase subunit 5A, mitochondrial	COX5A	0.0033
6498	Cytochrome c oxidase subunit 6B1	COX6B1	0.0033
6489	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	COX4I1	0.0033
6497	Cytochrome c oxidase subunit 6A2, mitochondrial	COX6A2	0.0033
5793	Cytochrome c oxidase subunit 2	MT-CO2	0.0033
6559	Cytochrome c oxidase subunit 2	ctaC	0.0033
6669	Cytochrome c oxidase subunit 2	ctaC	0.0033
6490	Cytochrome c oxidase subunit 3	MT-CO3	0.0033
371	Cytochrome c oxidase subunit 1	MT-CO1	0.0033
6558	Cytochrome c oxidase subunit 1	ctaD	0.0033
293	Gamma-glutamyl hydrolase	GGH	0.0033
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.0033
751	Potassium channel subfamily K member 6	KCNK6	0.0033
1374	Natriuretic peptides B	NPPB	0.0033
162	Retinoic acid receptor gamma-1	RARG	0.0032
1827	Gap junction alpha-1 protein	GJA1	0.0032
1908	Vascular cell adhesion protein 1	VCAM1	0.0032
4784	Beta-mannosidase	manB	0.0032
6695	Beta-mannosidase	BT_0458	0.0032
2207	Rhodopsin	RHO	0.0032
1313	Lactoylglutathione lyase	GLO1	0.0032
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0032
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0032
140	30S ribosomal protein S9	rpsI	0.0031
6719	30S ribosomal protein S9	rpsI	0.0031
6725	30S ribosomal protein S9	rpsI	0.0031
6168	Solute carrier family 22 member 16	SLC22A16	0.0031
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0031
6131	Carbonic anhydrase 14	CA14	0.0031
1636	Trace amine-associated receptor 1	TAAR1	0.0031
1353	DNA topoisomerase 1	TOP1	0.0031
3552	DNA topoisomerase 1	topA	0.0031
760	Fibroblast growth factor 1	FGF1	0.0031
1227	Cytochrome b	MT-CYB	0.0031
6386	Cytochrome b	petB	0.0031
6937	Cytochrome b	MT-CYB	0.0031
674	Dihydroorotate dehydrogenase homolog, mitochondrial	PFF0160c	0.0031
1517	Beta-3 adrenergic receptor	ADRB3	0.0031
2540	Choloylglycine hydrolase	cbh	0.0031
1864	RET proto-oncogene	RET	0.003
2578	Tubulin beta-3 chain	TUBB3	0.003
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.003
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.003
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.003
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.003
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.003
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.003
2285	Streptogramin A acetyltransferase	vatD	0.003
172	Potassium channel subfamily K member 1	KCNK1	0.003
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.003
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.003
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.003
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.003
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.003
636	Mitochondrial carnitine/acylcarnitine carrier protein	SLC25A20	0.0029
109	Mitochondrial carnitine/acylcarnitine carrier protein CACL	SLC25A29	0.0029
1039	Histone deacetylase 9	HDAC9	0.0029
6501	Fatty acid-binding protein, liver	FABP1	0.0029
424	Dihydroorotate dehydrogenase, mitochondrial	DHODH	0.0029
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0028
2998	Sialic acid-binding Ig-like lectin 7	SIGLEC7	0.0028
4217	Telomerase reverse transcriptase	TERT	0.0028
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0028
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0028
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0028
1200	AMBP protein	AMBP	0.0028
3866	Serum amyloid A protein	SAA1	0.0028
1932	Apolipoprotein E	APOE	0.0028
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0028
1144	Hepatocyte growth factor receptor	MET	0.0027
2449	Tubulin alpha-3 chain	TUBA1A	0.0027
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.0027
4173	Tyrosine-protein kinase JAK2	JAK2	0.0027
2159	Quinone oxidoreductase	CRYZ	0.0027
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.0027
1262	Corticotropin-lipotropin	POMC	0.0027
4228	Keratin, type II cytoskeletal 7	KRT7	0.0027
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0027
1714	Mitogen-activated protein kinase 3	MAPK3	0.0026
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0026
412	Peroxisomal carnitine O-octanoyltransferase	CROT	0.0026
3937	Fatty-acid amide hydrolase	FAAH	0.0026
551	Carnitine O-acetyltransferase	CRAT	0.0025
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0025
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0025
3639	Thymidine phosphorylase	deoA	0.0025
3936	Thymidine phosphorylase	TYMP	0.0025
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0025
3913	Glutamic acid decarboxylase	GAD65	0.0025
4787	Envelope glycoprotein gp160	env	0.0025
4820	Envelope glycoprotein gp160	env	0.0025
5727	Envelope glycoprotein gp160	env	0.0025
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0025
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0024
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0024
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0024
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0024
544	Potassium voltage-gated channel subfamily E member 1	KCNE1	0.0024
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0024
2300	Lysozyme	E	0.0024
3633	Lysozyme	R	0.0024
5597	Lysozyme	17	0.0024
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0024
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0024
2297	Genome polyprotein	Not Available	0.0024
2322	Genome polyprotein	Not Available	0.0024
2694	Genome polyprotein	Not Available	0.0024
2719	Genome polyprotein	Not Available	0.0024
2860	Genome polyprotein	Not Available	0.0024
2928	Genome polyprotein	Not Available	0.0024
3160	Genome polyprotein	Not Available	0.0024
3260	Genome polyprotein	Not Available	0.0024
4783	Genome polyprotein	Not Available	0.0024
5726	Genome polyprotein	Not Available	0.0024
5779	Genome polyprotein	Not Available	0.0024
5867	Genome polyprotein	Not Available	0.0024
6253	Genome polyprotein	Not Available	0.0024
6301	Genome polyprotein	Not Available	0.0024
6380	Genome polyprotein	Not Available	0.0024
6381	Genome polyprotein	Not Available	0.0024
6437	Genome polyprotein	Not Available	0.0024
6520	Genome polyprotein	Not Available	0.0024
6521	Genome polyprotein	Not Available	0.0024
6652	Genome polyprotein	Not Available	0.0024
6734	Genome polyprotein	Not Available	0.0024
6735	Genome polyprotein	Not Available	0.0024
6736	Genome polyprotein	Not Available	0.0024
6737	Genome polyprotein	Not Available	0.0024
6738	Genome polyprotein	Not Available	0.0024
6739	Genome polyprotein	Not Available	0.0024
6744	Genome polyprotein	Not Available	0.0024
6748	Genome polyprotein	Not Available	0.0024
6894	Genome polyprotein	Not Available	0.0024
6898	Genome polyprotein	Not Available	0.0024
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0024
233	Potassium channel subfamily K member 2	KCNK2	0.0024
229	Retinoic acid receptor beta	RARB	0.0024
5852	Type-2 angiotensin II receptor	AGTR2	0.0024
4773	Deoxycytidine kinase	DCK	0.0024
5934	Cytochrome P450 26A1	CYP26A1	0.0024
642	3-oxo-5-alpha-steroid 4-dehydrogenase 2	SRD5A2	0.0023
6048	Troponin C, skeletal muscle	TNNC2	0.0023
730	Retinoic acid receptor alpha	RARA	0.0023
4192	DNA topoisomerase 2-beta	TOP2B	0.0023
65	Matrix metalloproteinase-9	Not Available	0.0023
1341	Histamine H3 receptor	HRH3	0.0023
2236	Casein kinase II subunit alpha	CSNK2A1	0.0023
543	Penicillin-binding protein 1B	mrcB	0.0023
6186	Penicillin-binding protein 1B	ponB	0.0023
6822	Penicillin-binding protein 1b	pbp1b	0.0023
6844	Penicillin-binding protein 1b	pbp1b	0.0023
268	Adenosine A2b receptor	ADORA2B	0.0023
908	Glutathione S-transferase theta-1	GSTT1	0.0022
159	Penicillin-binding protein 2B	penA	0.0022
6121	Penicillin-binding protein 2B	penA	0.0022
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0022
5798	Mitogen-activated protein kinase 11	MAPK11	0.0022
3480	Mannan endo-1,4-beta-mannosidase	manA	0.0022
3404	Exotoxin A	eta	0.0022
2320	Thymidine kinase, cytosolic	TK1	0.0022
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0022
2232	Interleukin-5	IL5	0.0022
6824	Tyrosine-protein kinase Lyn	LYN	0.0021
298	Renin	REN	0.0021
1593	Mucin-2	MUC2	0.0021
3437	Eosinophil lysophospholipase	CLC	0.0021
735	Alanine aminotransferase 1	GPT	0.0021
3904	Alanine aminotransferase 2	GPT2	0.0021
63	Malate dehydrogenase	mdh	0.0021
2329	Malate dehydrogenase	mdh	0.0021
3445	Malate dehydrogenase	mdh	0.0021
4420	Malate dehydrogenase	mdh	0.0021
4438	Malate dehydrogenase	mdh	0.0021
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0021
3090	Chitosanase	csn	0.002
4149	Nuclear factor NF-kappa-B p100 subunit	NFKB2	0.002
936	Ephrin type-A receptor 2	EPHA2	0.002
3611	Cytidine deaminase	cdd	0.002
3707	Cytidine deaminase	cdd	0.002
4211	Cytidine deaminase	CDA	0.002
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0019
6218	Pannexin-1	PANX1	0.0019
2216	Fibroblast growth factor receptor 4	FGFR4	0.0019
1291	cAMP response element-binding protein	CREB1	0.0019
2499	Tubulin beta-2C chain	TUBB2C	0.0019
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0019
473	L-lactate dehydrogenase A chain	LDHA	0.0019
3426	Glutamine synthetase	glnA	0.0019
3987	Glutamine synthetase	GLUL	0.0019
477	DNA topoisomerase 4 subunit A	parC	0.0019
886	DNA topoisomerase 4 subunit A	parC	0.0019
6226	DNA topoisomerase 4 subunit A	parC	0.0019
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0019
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0018
404	DNA gyrase subunit A	gyrA	0.0018
6224	DNA gyrase subunit A	gyrA	0.0018
893	[Citrate [pro-3S]-lyase] ligase	citC	0.0018
845	Pyruvate dehydrogenase [cytochrome]	poxB	0.0018
1253	Interferon gamma	IFNG	0.0018
4210	Toll-like receptor 4	TLR4	0.0018
5998	Toll-like receptor 8	TLR8	0.0018
4238	50S ribosomal protein L4	rplD	0.0018
5578	50S ribosomal protein L4	rplD	0.0018
6173	50S ribosomal protein L4	rplD	0.0018
6219	50S ribosomal protein L4	rplD	0.0018
712	Tubulin alpha chain	TUB1	0.0018
1968	ATP-sensitive inward rectifier potassium channel 12	KCNJ12	0.0018
327	Glutathione reductase	gor	0.0018
5110	Glutathione reductase	GR2	0.0018
683	Potassium transporter	GK0582	0.0018
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0018
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.0018
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0018
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0018
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0018
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0018
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0018
1123	Eosinophil cationic protein	RNASE3	0.0018
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0017
613	Atrial natriuretic peptide receptor A	NPR1	0.0017
719	Retinoic acid receptor responder protein 1	RARRES1	0.0017
770	Retinoic acid-induced protein 3	GPRC5A	0.0017
251	Alcohol dehydrogenase 1A	ADH1A	0.0017
2290	ADP-ribosyl cyclase 2	BST1	0.0017
992	Protein tyrosine kinase 2 beta	PTK2B	0.0017
3830	Calreticulin	CALR	0.0017
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0016
820	Glycine receptor subunit alpha-2	GLRA2	0.0016
144	Hemoglobin subunit alpha	HBA1	0.0016
4226	Uridine phosphorylase 2	UPP2	0.0016
6034	Hydroxyindole O-methyltransferase	ASMT	0.0016
6035	Nuclear receptor ROR-beta	RORB	0.0016
6036	Eosinophil peroxidase	EPX	0.0016
822	Aldose reductase	AKR1B1	0.0016
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0016
3233	Bile acid receptor	NR1H4	0.0015
444	Alcohol dehydrogenase 1B	ADH1B	0.0015
569	Retinal dehydrogenase 2	ALDH1A2	0.0015
4785	Ig gamma-1 chain C region	IGHG1	0.0015
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0015
982	Cocaine- and amphetamine-regulated transcript protein	CARTPT	0.0015
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0015
291	Nitric-oxide synthase, endothelial	NOS3	0.0015
3957	Adenosine deaminase	ADA	0.0015
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.0015
4225	Uridine phosphorylase 1	UPP1	0.0015
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0015
611	Retinal dehydrogenase 1	ALDH1A1	0.0014
605	Fumarate reductase flavoprotein subunit	frdA	0.0014
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0014
3673	Fumarate reductase flavoprotein subunit	fccA	0.0014
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0014
6549	Fumarate reductase flavoprotein subunit	frdA	0.0014
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.0014
2599	Tyrosine-protein kinase HCK	HCK	0.0014
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.0014
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0014
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0014
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.0014
413	Amidophosphoribosyltransferase	PPAT	0.0014
2515	Amidophosphoribosyltransferase	purF	0.0014
3714	Amidophosphoribosyltransferase	purF	0.0014
765	Indoleamine 2,3-dioxygenase	IDO1	0.0014
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0013
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0013
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0013
244	Angiotensin-converting enzyme	ACE	0.0013
6211	Tubulin epsilon chain	TUBE1	0.0013
6212	Tubulin gamma-1 chain	TUBG1	0.0013
6210	Tubulin delta chain	TUBD1	0.0013
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0013
860	Nicotinamide N-methyltransferase	NNMT	0.0013
699	Nicotinic acid receptor 1	GPR109A	0.0013
928	Nicotinic acid receptor 2	GPR109B	0.0013
583	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	QPRT	0.0013
2442	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0013
2459	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0013
6116	Gastric triacylglycerol lipase	LIPF	0.0012
4948	Cytochrome c-553	Not Available	0.0012
4923	Cytochrome c3	DvMF_2499	0.0012
4945	Cytochrome c3	Not Available	0.0012
4949	Cytochrome c3	DVU_3171	0.0012
4968	Cytochrome c3	cytc3	0.0012
4997	Cytochrome c3	SO_2727	0.0012
5219	Cytochrome c3	cyd	0.0012
4902	Nine-heme cytochrome c	Ddes_2038	0.0012
3189	High-molecular-weight cytochrome c	hmcA	0.0012
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0012
3823	Cytokine receptor common gamma chain	IL2RG	0.0012
2107	Microtubule-associated protein 1A	MAP1A	0.0012
338	DNA polymerase	UL30	0.0012
379	DNA polymerase	UL54	0.0012
697	DNA polymerase	ORF28	0.0012
2482	DNA polymerase	43	0.0012
4104	DNA polymerase	BALF5	0.0012
6122	Carbonic anhydrase 3	CA3	0.0012
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0012
1295	Fatty acid synthase	FASN	0.0012
1268	Neuropeptide S receptor	NPSR1	0.0012
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0012
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0012
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0012
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0012
5433	UPF0230 protein TM_1468	TM_1468	0.0012
5431	Lipid binding protein	Not Available	0.0012
3616	Fatty acid-binding protein, epidermal	FABP5	0.0012
5430	Hepatocyte nuclear factor 4-gamma	HNF4G	0.0012
754	Pancreatic triacylglycerol lipase	PNLIP	0.0011
707	72 kDa type IV collagenase	MMP2	0.0011
6073	Potassium channel subfamily K member 9	KCNK9	0.0011
6072	Potassium channel subfamily K member 3	KCNK3	0.0011
896	Glutathione S-transferase Mu 1	GSTM1	0.0011
2178	Metabotropic glutamate receptor 5	GRM5	0.0011
724	Interleukin-2 receptor alpha chain	IL2RA	0.0011
4386	Hemoglobin-like protein HbN	glbN	0.0011
717	Interleukin-2 receptor subunit beta	IL2RB	0.0011
1810	Protein S100-A1	S100A1	0.001
6097	Protein S100-A2	S100A2	0.001
493	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	0.001
283	SEC14-like protein 2	SEC14L2	0.001
512	DNA-directed RNA polymerase alpha chain	rpoA	0.001
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.001
4041	Microsomal glutathione S-transferase 2	MGST2	0.001
2298	Cytochrome P450-cam	camC	0.001
6837	Serine/threonine-protein kinase 17B	STK17B	0.001
6836	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	HIBCH	0.001
3221	Cytochrome c4	cc4	0.001
76	Nitric-oxide synthase, brain	NOS1	0.0009
2268	Cholesterol oxidase	choB	0.0009
2822	Cholesterol oxidase	choA	0.0009
5432	Trafficking protein particle complex subunit 3	TRAPPC3	0.0009
2211	Fatty acid-binding protein, heart	FABP3	0.0009
6459	Glycodelin	PAEP	0.0009
1064	DNA (cytosine-5)-methyltransferase 1	DNMT1	0.0009
6105	3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	0.0009
828	Phenylalanine-4-hydroxylase	PAH	0.0009
3109	Phenylalanine-4-hydroxylase	phhA	0.0009
1048	Protein S100-A13	S100A13	0.0009
2226	Protein S100-A12	S100A12	0.0009
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0009
1770	Phospholipase C	PLCL1	0.0009
2841	Phospholipase C	plc	0.0009
6677	Myelin P2 protein	PMP2	0.0009
2283	Steroid Delta-isomerase	ksi	0.0009
2920	Steroid Delta-isomerase	ksi	0.0009
4954	Soluble cytochrome b558	Not Available	0.0009
4916	Cyanoglobin	glbN	0.0009
4934	Cytochrome c-551	nirM	0.0009
5218	Cytochrome c-551	nirM	0.0009
4947	Bacterial hemoglobin	vhb	0.0009
4943	Cytochrome c6	petJ	0.0009
4915	Cytochrome c-550	psbV	0.0009
4959	Cytochrome c-550	psbV	0.0009
5216	Cytochrome c-550	psbV	0.0009
4925	Cytochrome c-type protein SHP	shp	0.0009
4905	Cytochrome c2	Not Available	0.0009
4939	Cytochrome c2	cycA	0.0009
4964	Cytochrome c2	cycA	0.0009
4979	Cytochrome c2	cycA	0.0009
6673	Cytochrome c2	cycA	0.0009
4975	Cytochrome c-556	RPA3973	0.0009
390	Adenosine A3 receptor	ADORA3	0.0009
4994	Hemoglobin-like protein HbO	glbO	0.0009
4936	Cytochrome c2 iso-2	Not Available	0.0009
4984	Neuroglobin	NGB	0.0009
4998	Hemoglobin-like protein yjbI	yjbI	0.0009
4942	Diheme cytochrome c napB	napB	0.0009
4961	Hemophore HasA	hasA	0.0009
4909	CooA protein	cooA	0.0009
4981	Iron-starvation protein PigA	pigA	0.0009
5000	HemO	hemO	0.0009
644	Heme oxygenase 2	HMOX2	0.0009
4982	Heme oxygenase 2	pbsA2	0.0009
3116	Bacterioferritin	bfr	0.0009
4906	Bacterioferritin	bfr	0.0009
4965	Bacterioferritin	bfr	0.0009
4904	Cytochrome c family protein	GSU1996	0.0009
4907	Cytochrome c-L	moxG	0.0009
6865	Cytochrome c-L	moxG	0.0009
4910	Cytoglobin	CYGB	0.0009
4976	Apocytochrome f	petA	0.0009
6407	Apocytochrome f	petA	0.0009
4971	Nonaheme cytochrome c	hmcA	0.0009
4935	Cytochrome c-554	cycA1	0.0009
4989	Cytochrome c551 peroxidase	ccp	0.0009
5222	Cytochrome c551 peroxidase	ccpA	0.0009
4937	Cytochrome oxidase subunit II	rcoxA	0.0009
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0009
4764	Cytochrome P450 165C4	CYP165C4	0.0009
4999	Cytochrome P450 165B3	CYP165B3	0.0009
4960	Putative cytochrome P450-family protein	SCO7417	0.0009
4931	Cytochrome P450 167A1	CYP167A1	0.0009
4972	P450cin	cinA	0.0009
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0009
4993	Hydroxylamine oxidoreductase	hao1	0.0009
4922	Cytochrome c, putative	SO_4144	0.0009
4903	Methyl-accepting chemotaxis protein	Tar4	0.0009
4952	Catalase/peroxidase	katA	0.0009
3093	Catalase HPII	katE	0.0009
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0009
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0009
2132	Protein S100-B	S100B	0.0009
6656	UDP-glucuronosyltransferase 3A1	UGT3A1	0.0008
1184	Interferon beta	IFNB1	0.0008
22	30S ribosomal protein S4	rpsD	0.0008
6714	30S ribosomal protein S4	rpsD	0.0008
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0008
1867	Major prion protein	PRNP	0.0008
4031	Glutathione S-transferase A1	GSTA1	0.0008
6599	HTH-type transcriptional regulator ttgR	ttgR	0.0008
500	Monocarboxylate transporter 4	SLC16A3	0.0008
1649	Small inducible cytokine A2	CCL2	0.0008
1025	Aquaporin-1	AQP1	0.0008
2091	Endoplasmin	HSP90B1	0.0008
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.0007
866	Large neutral amino acids transporter small subunit 2	SLC7A8	0.0007
461	Glycine receptor subunit alpha-3	GLRA3	0.0007
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0007
6344	ATP synthase subunit gamma, mitochondrial	ATP5C1	0.0007
6343	ATP synthase subunit beta, mitochondrial	ATP5B	0.0007
6342	ATP synthase subunit alpha, mitochondrial	ATP5A1	0.0007
6207	30S ribosomal protein S14	rpsN	0.0007
6209	30S ribosomal protein S19	rpsS	0.0007
6712	30S ribosomal protein S19	rpsS	0.0007
6726	30S ribosomal protein S19	rpsS	0.0007
6134	Sodium channel subunit beta-3	SCN3B	0.0007
6133	Sodium channel subunit beta-2	SCN2B	0.0007
6135	Sodium channel subunit beta-4	SCN4B	0.0007
6132	Sodium channel subunit beta-1	SCN1B	0.0007
6129	Carbonic anhydrase-related protein 11	CA11	0.0007
6127	Carbonic anhydrase-related protein	CA8	0.0007
6128	Carbonic anhydrase-related protein 10	CA10	0.0007
645	Penicillin-binding protein 1A	mrcA	0.0007
5805	Penicillin-binding protein 1A	ponA	0.0007
6185	Penicillin-binding protein 1A	mrcA	0.0007
6799	Penicillin-binding protein 1A	pbpA	0.0007
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.0007
226	Gonadotropin-releasing hormone receptor	GNRHR	0.0007
1830	5'-nucleotidase	NT5E	0.0007
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0007
4666	Fucose-binding lectin PA-IIL	lecB	0.0007
2372	Bifunctional tail protein	9	0.0007
125	DNA polymerase beta	POLB	0.0007
4920	Peroxidase/catalase	katG	0.0006
4878	Glycoprotein hormones alpha chain	CGA	0.0006
1052	Cytotoxic T-lymphocyte protein 4	CTLA4	0.0006
1072	Granzyme B	GZMB	0.0006
4871	Endo-beta-N-acetylglucosaminidase F3	endOF3	0.0006
4880	Membrane cofactor protein	CD46	0.0006
4889	Ig epsilon chain C region	IGHE	0.0006
4877	Beta-mannanase	man	0.0006
1563	Platelet glycoprotein Ib alpha chain	GP1BA	0.0006
4850	Beta-2-glycoprotein 1	APOH	0.0006
4856	CD209 antigen	CD209	0.0006
4189	Alpha-galactosidase A	GLA	0.0006
4869	Major capsid protein	A430L	0.0006
757	Fusion glycoprotein F0	F	0.0006
4875	Fusion glycoprotein F0	F	0.0006
4852	Reticulon-4 receptor	RTN4R	0.0006
4845	ADAM 33	ADAM33	0.0006
1354	Beta-glucuronidase	GUSB	0.0006
4882	Dipeptidyl aminopeptidase-like protein 6	DPP6	0.0006
4721	Beta-1,4-mannanase	manA	0.0006
3352	Structural polyprotein	Not Available	0.0006
3628	Structural polyprotein	Not Available	0.0006
4892	Structural polyprotein	Not Available	0.0006
2119	Cytochrome b5	CYB5A	0.0006
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0006
4990	PpcA	ppcA	0.0006
4988	Sulfite oxidase, mitochondrial	SUOX	0.0006
4037	Hypothetical protein	GPX1	0.0006
4297	Hypothetical protein	SP_1951	0.0006
4521	Hypothetical protein	BC_2969	0.0006
4540	Hypothetical protein	TM_1070	0.0006
4555	Hypothetical protein	MT1739	0.0006
4569	Hypothetical protein	mshD	0.0006
4578	Hypothetical protein	PA3270	0.0006
4747	Hypothetical protein	PA3967	0.0006
5177	Hypothetical protein	TM_0096	0.0006
5194	Hypothetical protein	PA1204	0.0006
5240	Hypothetical protein	Rv2991	0.0006
5370	Hypothetical protein	TM_1158	0.0006
5710	Hypothetical protein	Tb927.5.1360	0.0006
3375	Acidic cytochrome c3	Not Available	0.0006
3570	Cytochrome P450 152A1	cypC	0.0006
2915	Sensor protein fixL	fixL	0.0006
4944	Sensor protein fixL	fixL	0.0006
4289	Cytochrome P450	TT_P0059	0.0006
6262	Cytochrome P450	staP	0.0006
4992	Cytochrome c peroxidase	Not Available	0.0006
4385	Cytochrome c'	Not Available	0.0006
4967	Cytochrome c'	cycA	0.0006
5038	Cytochrome c'	Not Available	0.0006
5223	Cytochrome c'	cycP	0.0006
4813	Heme oxygenase	hmuO	0.0006
5769	Heme oxygenase	Not Available	0.0006
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0006
6259	(3R)-hydroxymyristoyl-acyl carrier protein dehydratase	fabZ	0.0006
2230	Catalase	CAT	0.0006
3249	Catalase	katA	0.0006
3625	Catalase	katA	0.0006
4539	Catalase	katA	0.0006
4941	Catalase	katB	0.0006
6130	Carbonic anhydrase 13	CA13	0.0006
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0006
2404	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PIK3CG	0.0006
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0006
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0006
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0006
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0006
1569	G1/S-specific cyclin-D1	CCND1	0.0006
3670	Soluble cytochrome b562 precursor	cybC	0.0006
4193	Atrial natriuretic peptide clearance receptor	NPR3	0.0006
793	T-cell surface antigen CD2	CD2	0.0006
4861	Interleukin-6 receptor alpha chain	IL6R	0.0006
119	Carcinoembryonic antigen-related cell adhesion molecule 1	CEACAM1	0.0006
3837	Cytokine receptor common beta chain	CSF2RB	0.0006
3411	Cytochrome P450 121	cyp121	0.0006
5221	Cytochrome c3, 13 kDa	Not Available	0.0006
3152	Cytochrome c''	cycA	0.0006
5220	Split-Soret cytochrome c	Ddes_2150	0.0006
3700	Cytochrome c-552 precursor	nrfA	0.0006
2617	Nitric oxide synthase oxygenase	nos	0.0005
2701	Nitric oxide synthase oxygenase	nos	0.0005
3291	Cytochrome c-552	cycA	0.0005
4927	Cytochrome c-552	nrfA	0.0005
4938	Cytochrome c-552	cycA	0.0005
4953	Cytochrome c-552	nrfA	0.0005
5217	Cytochrome c-552	cycM	0.0005
3102	Flavohemoprotein	hmp	0.0005
4969	Flavohemoprotein	hmp	0.0005
2430	Chondroitinase B	cslB	0.0005
2347	Proto-oncogene serine/threonine-protein kinase Pim-1	PIM1	0.0005
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0005
3007	Carbonic anhydrase 12	CA12	0.0005
4205	Carbonic anhydrase 9	CA9	0.0005
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0005
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0005
1379	Interleukin-12 subunit beta	IL12B	0.0005
4890	Hemagglutinin	HA	0.0005
6566	Hemagglutinin	Not Available	0.0005
3127	Nitrite reductase	nirS	0.0005
3284	Nitrite reductase	nirS	0.0005
4857	Zinc-alpha-2-glycoprotein	AZGP1	0.0005
6858	Inactive carboxylesterase 4	CES1P1	0.0005
4608	Putative cytochrome P450	SCO1207	0.0005
4963	Putative cytochrome P450	SCO2884	0.0005
6254	Putative cytochrome P450	SCO6998	0.0005
6120	Cation-independent mannose-6-phosphate receptor	IGF2R	0.0005
18	High affinity immunoglobulin epsilon receptor subunit alpha	FCER1A	0.0005
554	Low-density lipoprotein receptor	LDLR	0.0004
852	Heparin cofactor 2	SERPIND1	0.0004
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0004
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0004
358	Cystathionine beta-synthase	CBS	0.0004
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0004
3405	Quinohaemoprotein ethanol dehydrogenase type-1	qheDH	0.0004
1859	Prostatic acid phosphatase	ACPP	0.0004
693	Hemoglobin subunit beta	HBB	0.0004
595	Fibrinogen alpha chain	FGA	0.0004
3140	Hemagglutinin-neuraminidase	HN	0.0004
3609	Hemagglutinin-neuraminidase	HN	0.0004
3444	Cyanovirin-N	Not Available	0.0004
3258	Mannosyl-oligosaccharide alpha-1,2-mannosidase	MSDC	0.0004
6163	Copper-transporting ATPase 2	ATP7B	0.0004
6165	Copper-transporting ATPase 1	ATP7A	0.0004
6268	Hydroxyacid oxidase 1	HAO1	0.0004
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0004
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0004
810	Heme oxygenase 1	HMOX1	0.0004
3391	Heme oxygenase 1	pbsA1	0.0004
4509	Acetoin(diacetyl) reductase	budC	0.0004
1176	Mitogen-activated protein kinase 1	MAPK1	0.0004
958	Insulin-like growth factor 1 receptor	IGF1R	0.0004
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0004
3689	Endoglucanase A	celA	0.0004
3814	Complement C1r subcomponent	C1R	0.0004
3009	Beta-glucanase	Not Available	0.0004
5411	Slt-IIvB	stxB2e	0.0004
5565	Inorganic polyphosphate/ATP-glucomannokinase	ppgmk	0.0004
5563	Galectin-2	LGALS2	0.0004
1875	Pulmonary surfactant-associated protein D	SFTPD	0.0004
5569	Endo-1,4-beta glucanase EngF	engF	0.0004
5046	Ecotin	eco	0.0004
3793	Aspartate ammonia-lyase	aspA	0.0004
5554	D-galactose-binding periplasmic protein	mglB	0.0004
3741	D-galactose-binding periplasmic protein precursor	mglB	0.0004
5568	Endoglucanase C307	celC307	0.0004
5553	Endoglucanase E1	Acel_0614	0.0004
5562	Hexokinase	Not Available	0.0004
3744	Endoglucanase SS precursor	celS	0.0004
5570	Endoglucanase E-4	celD	0.0004
5559	Neopullulanase	nplT	0.0004
4670	Cellulase B	celB	0.0004
4668	Laminarinase	TM_0024	0.0004
4667	BH0236 protein	BH0236	0.0004
4671	Endoglucanase C	cenC	0.0004
64	Neuraminidase	NA	0.0004
641	Neuraminidase	NA	0.0004
2676	Neuraminidase	NA	0.0004
3026	Neuraminidase	NA	0.0004
3519	Neuraminidase	NA	0.0004
6007	Neuraminidase	NA	0.0004
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0004
2577	Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase	MAN1B1	0.0004
1243	Cathepsin D	CTSD	0.0003
1439	Lactotransferrin	LTF	0.0003
309	Antithrombin-III	SERPINC1	0.0003
1782	Neutrophil gelatinase-associated lipocalin	LCN2	0.0003
484	Tyrosine-protein kinase ABL2	ABL2	0.0003
2240	Cell division protein kinase 2	CDK2	0.0003
5176	YtnJ	moxC	0.0003
5416	Coat protein VP1	Not Available	0.0003
2705	Dimethyl sulfoxide reductase	dmsA	0.0003
5247	Endo-1,4-beta-xylanase	Not Available	0.0003
5248	Endo-1,4-beta-xylanase	xlnA	0.0003
5250	Endo-1,4-beta-xylanase	xyl	0.0003
4669	Endo-1,4-beta-xylanase A	xynA	0.0003
4715	Endo-1,4-beta-xylanase A	xlnA	0.0003
5560	Endo-1,4-beta-xylanase A	xynA	0.0003
1503	Galectin-7	LGALS7	0.0003
5498	Maltoporin	lamB	0.0003
5561	Maltoporin	lamB	0.0003
5056	Maltooligosyltrehalose trehalohydrolase, putative	treZ	0.0003
3525	ADP-ribose pyrophosphatase, mitochondrial	NUDT9	0.0003
4622	Amylase	Not Available	0.0003
2728	Glucan 1,4-alpha-maltotetraohydrolase	amyP	0.0003
6307	Ig gamma-2 chain C region	IGHG2	0.0003
2826	Glucose--fructose oxidoreductase	gfo	0.0003
1881	Hexokinase-1	HK1	0.0003
2581	Chondroitinase AC	cslA	0.0003
6847	Lactase-phlorizin hydrolase	LCT	0.0003
2324	Botulinum neurotoxin type B	botB	0.0003
3153	Quinoprotein glucose dehydrogenase-B	gdhB	0.0003
3747	Cellulase B precursor	celB	0.0003
3547	Enterotoxin type B	entB	0.0003
2856	Glucosamine-6-phosphate isomerase	GNPDA1	0.0003
2564	Glucan 1,4-alpha-maltohexaosidase	Not Available	0.0003
4819	Hydrolase	Not Available	0.0003
5249	Hydrolase	Not Available	0.0003
5436	Hydrolase	Not Available	0.0003
2531	Alpha-amylase	amyE	0.0003
2948	Alpha-amylase	amy	0.0003
3169	Alpha-amylase	Not Available	0.0003
2541	Neopullulanase 1	tvaI	0.0003
4811	Amylosucrase	ams	0.0003
3091	Maltodextrin phosphorylase	malP	0.0003
2606	Neopullulanase 2	tvaII	0.0003
4692	A/G-specific adenine glycosylase	mutY	0.0003
3225	Shiga toxin B-chain	stxB	0.0003
3365	Beta-amylase	spoII	0.0003
4830	Aldose 1-epimerase	galM	0.0003
6614	Lactase-like protein	LCTL	0.0003
1675	Glucokinase	GCK	0.0003
4662	Glucokinase	glk	0.0003
3030	Salivary alpha-amylase	AMY1A	0.0003
2293	Cyclomaltodextrin glucanotransferase	Not Available	0.0003
2508	Cyclomaltodextrin glucanotransferase	cgt	0.0003
2523	Cyclomaltodextrin glucanotransferase	cgt	0.0003
3207	Cyclomaltodextrin glucanotransferase	amyA	0.0003
4272	POSSIBLE CELLULASE CELA1	celA1	0.0003
2570	Tetanus toxin	tetX	0.0002
2448	Exoglucanase/xylanase [Includes: Exoglucanase	cex	0.0002
3668	Maltose-binding periplasmic protein precursor	malE	0.0002
2802	Endoglucanase G	celCCG	0.0002
2440	Endoglucanase F	celCCF	0.0002
2245	Xylose isomerase	xylA	0.0002
2253	Xylose isomerase	xylA	0.0002
2260	Xylose isomerase	xylA	0.0002
2431	Xylose isomerase	xylA	0.0002
2252	Endoglucanase 5A	cel5A	0.0002
10	Glycogen phosphorylase, liver form	PYGL	0.0002
2723	Cholera enterotoxin subunit B	ctxB	0.0002
4513	Pancreatic alpha-amylase	AMY2A	0.0002
2427	Ferrichrome-iron receptor	fhuA	0.0002
1152	Glycogen phosphorylase, muscle form	PYGM	0.0002

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB01132 - Pioglitazone

Targets

Enzymes

Transporters

Predictions