DT-Web: DB00197

Identification

Name

Troglitazone

Accession Number

DB00197 (APRD00488)

Type

small molecule

Description

Troglitazone was withdrawn in 2000 due to risk of hepatotoxicity. It was superseded by pioglitazone and rosiglitazone.

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

441.54

Groups

withdrawn

Monoisotopic Weight

441.160993669

Pharmacology

Indication

For the treatment of Type II diabetes mellitus. It is used alone or in combination with a sulfonylurea, metformin, or insulin as an adjunct to diet and exercise.

Mechanism of action

Troglitazone is a thiazolidinedione antidiabetic agent that lowers blood glucose by improving target cell response to insulin. It has a unique mechanism of action that is dependent on the presence of insulin for activity. Troglitazone decreases hepatic glucose output and increases insulin dependent glucose disposal in skeletal muscle. Its mechanism of action is thought to involve binding to nuclear receptors (PPAR) that regulate the transcription of a number of insulin responsive genes critical for the control of glucose and lipid metabolism. Troglitazone is a ligand to both PPAR? and PPAR?, with a highter affinity for PPAR?. The drug also contains an ?-tocopheroyl moiety, potentially giving it vitamin E-like activity. Troglitazone has been shown to reduce inflammation, and is associated with a decrase in nuclear factor kappa-B (NF-?B) and a concomitant increase in its inhibitor (I?B). NF-?B is an important cellular transcription regulator for the immune response. Unlike sulfonylureas, troglitazone is not an insulin secretagogue.

Absorption

Absorbed rapidly. Food increases the extent of absorption by 30% to 85%.

Protein binding

> 99% (primarily to serum albumin)

Biotransformation

A sulfate conjugate metabolite (Metabolite 1) and a quinone metabolite (Metabolite 3) have been detected in the plasma of healthy males. A glucuronide conjugate (Metabolite 2) has been detected in the urine and also in negligible amounts in the plasma. In healthy volunteers and in patients with type 2 diabetes, the steady-state concentration of Metabolite 1 is six to seven times that of troglitazone and Metabolite 3. In in vivo drug interaction studies, troglitazone has been shown to induce cytochrome P450 CYP3A4 at clinically relevant doses.

Route of elimination

Not Available

Toxicity

Not Available

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Cholestyramine	Decreases the effect of troglitazone
Cyclosporine	Troglitazone decreases the effect of the immunosuppressant
Ethinyl Estradiol	Possible loss of contracepitve effect
Norethindrone	Possible loss of contraceptive effect

Food Interactions

Not Available

Peroxisome proliferator-activated receptor gamma
Name	Peroxisome proliferator-activated receptor gamma
Gene Name	PPARG
Pharmacological action	yes
Actions	agonist
References	Kitamura S, Miyazaki Y, Shinomura Y, Kondo S, Kanayama S, Matsuzawa Y: Peroxisome proliferator-activated receptor gamma induces growth arrest and differentiation markers of human colon cancer cells. Jpn J Cancer Res. 1999 Jan;90(1):75-80. - Pubmed Demetri GD, Fletcher CD, Mueller E, Sarraf P, Naujoks R, Campbell N, Spiegelman BM, Singer S: Induction of solid tumor differentiation by the peroxisome proliferator-activated receptor-gamma ligand troglitazone in patients with liposarcoma. Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):3951-6. - Pubmed Petrova TV, Akama KT, Van Eldik LJ: Cyclopentenone prostaglandins suppress activation of microglia: down-regulation of inducible nitric-oxide synthase by 15-deoxy-Delta12,14-prostaglandin J2. Proc Natl Acad Sci U S A. 1999 Apr 13;96(8):4668-73. - Pubmed Camp HS, Whitton AL, Tafuri SR: PPARgamma activators down-regulate the expression of PPARgamma in 3T3-L1 adipocytes. FEBS Lett. 1999 Mar 26;447(2-3):186-90. - Pubmed Satoh T, Furuta K, Suzuki M, Watanabe Y: Prostaglandin J2 and its metabolites promote neurite outgrowth induced by nerve growth factor in PC12 cells. Biochem Biophys Res Commun. 1999 Apr 29;258(1):50-3. - Pubmed Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed Baek SJ, Wilson LC, Hsi LC, Eling TE: Troglitazone, a peroxisome proliferator-activated receptor gamma (PPAR gamma ) ligand, selectively induces the early growth response-1 gene independently of PPAR gamma. A novel mechanism for its anti-tumorigenic activity. J Biol Chem. 2003 Feb 21;278(8):5845-53. Epub 2002 Dec 9. - Pubmed
DTHybrid score	1.0962
Long-chain-fatty-acid--CoA ligase 4
Name	Long-chain-fatty-acid--CoA ligase 4
Gene Name	ACSL4
Pharmacological action	no
Actions	inhibitor
References	Kim JH, Lewin TM, Coleman RA: Expression and characterization of recombinant rat Acyl-CoA synthetases 1, 4, and 5. Selective inhibition by triacsin C and thiazolidinediones. J Biol Chem. 2001 Jul 6;276(27):24667-73. Epub 2001 Apr 23. - Pubmed Lewin TM, Van Horn CG, Krisans SK, Coleman RA: Rat liver acyl-CoA synthetase 4 is a peripheral-membrane protein located in two distinct subcellular organelles, peroxisomes, and mitochondrial-associated membrane. Arch Biochem Biophys. 2002 Aug 15;404(2):263-70. - Pubmed Lewin TM, Kim JH, Granger DA, Vance JE, Coleman RA: Acyl-CoA synthetase isoforms 1, 4, and 5 are present in different subcellular membranes in rat liver and can be inhibited independently. J Biol Chem. 2001 Jul 6;276(27):24674-9. Epub 2001 Apr 23. - Pubmed
DTHybrid score	0.2279
Plasminogen activator inhibitor 1
Name	Plasminogen activator inhibitor 1
Gene Name	SERPINE1
Pharmacological action	unknown
Actions	antagonist
References	Sobel BE: Insulin resistance and thrombosis: a cardiologist's view. Am J Cardiol. 1999 Jul 8;84(1A):37J-41J. - Pubmed Gottschling-Zeller H, Rohrig K, Hauner H: Troglitazone reduces plasminogen activator inhibitor-1 expression and secretion in cultured human adipocytes. Diabetologia. 2000 Mar;43(3):377-83. - Pubmed Nordt TK, Peter K, Bode C, Sobel BE: Differential regulation by troglitazone of plasminogen activator inhibitor type 1 in human hepatic and vascular cells. J Clin Endocrinol Metab. 2000 Apr;85(4):1563-8. - Pubmed Kato K, Yamada D, Midorikawa S, Sato W, Watanabe T: Improvement by the insulin-sensitizing agent, troglitazone, of abnormal fibrinolysis in type 2 diabetes mellitus. Metabolism. 2000 May;49(5):662-5. - Pubmed Kruszynska YT, Yu JG, Olefsky JM, Sobel BE: Effects of troglitazone on blood concentrations of plasminogen activator inhibitor 1 in patients with type 2 diabetes and in lean and obese normal subjects. Diabetes. 2000 Apr;49(4):633-9. - Pubmed
DTHybrid score	0.4244
Equilibrative nucleoside transporter 1
Name	Equilibrative nucleoside transporter 1
Gene Name	SLC29A1
Pharmacological action	no
Actions	inhibitor
References	Leung GP, Man RY, Tse CM: Effect of thiazolidinediones on equilibrative nucleoside transporter-1 in human aortic smooth muscle cells. Biochem Pharmacol. 2005 Aug 1;70(3):355-62. - Pubmed
DTHybrid score	0.3427
Estrogen-related receptor gamma
Name	Estrogen-related receptor gamma
Gene Name	ESRRG
Pharmacological action	no
Actions	inverse agonist
References	Wang Y, Fang F, Wong CW: Troglitazone is an estrogen-related receptor alpha and gamma inverse agonist. Biochem Pharmacol. 2010 Jul 1;80(1):80-5. Epub 2010 Mar 16. - Pubmed
DTHybrid score	1.0012
Steroid hormone receptor ERR1
Name	Steroid hormone receptor ERR1
Gene Name	ESRRA
Pharmacological action	no
Actions	inverse agonist
References	Wang Y, Fang F, Wong CW: Troglitazone is an estrogen-related receptor alpha and gamma inverse agonist. Biochem Pharmacol. 2010 Jul 1;80(1):80-5. Epub 2010 Mar 16. - Pubmed
DTHybrid score	0.9772

Cytochrome P450 3A4
Name	Cytochrome P450 3A4
Gene Name	CYP3A4
Actions	substrate,inhibitor,inducer
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	1.0806
Cytochrome P450 2C8
Name	Cytochrome P450 2C8
Gene Name	CYP2C8
Actions	substrate,inhibitor
References	Schoch GA, Yano JK, Sansen S, Dansette PM, Stout CD, Johnson EF: Determinants of cytochrome P450 2C8 substrate binding: structures of complexes with montelukast, troglitazone, felodipine, and 9-cis-retinoic acid. J Biol Chem. 2008 Jun 20;283(25):17227-37. Epub 2008 Apr 15. - Pubmed Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.6865
UDP-glucuronosyltransferase 1-1
Name	UDP-glucuronosyltransferase 1-1
Gene Name	UGT1A1
Actions	substrate
References	Watanabe Y, Nakajima M, Yokoi T: Troglitazone glucuronidation in human liver and intestine microsomes: high catalytic activity of UGT1A8 and UGT1A10. Drug Metab Dispos. 2002 Dec;30(12):1462-9. - Pubmed
DTHybrid score	0.4788
Cytochrome P450 2C19
Name	Cytochrome P450 2C19
Gene Name	CYP2C19
Actions	substrate,inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.6745
Cytochrome P450 19A1
Name	Cytochrome P450 19A1
Gene Name	CYP19A1
Actions	inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.4466
Cytochrome P450 1A1
Name	Cytochrome P450 1A1
Gene Name	CYP1A1
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.3763
Cytochrome P450 2B6
Name	Cytochrome P450 2B6
Gene Name	CYP2B6
Actions	inducer
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.4923
Cytochrome P450 2C9
Name	Cytochrome P450 2C9
Gene Name	CYP2C9
Actions	substrate,inhibitor
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.8377
Cytochrome P450 3A5
Name	Cytochrome P450 3A5
Gene Name	CYP3A5
Actions	inhibitor,inducer
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.6291
Cytochrome P450 3A7
Name	Cytochrome P450 3A7
Gene Name	CYP3A7
Actions	inhibitor,inducer
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.4697
UDP-glucuronosyltransferase 1-3
Name	UDP-glucuronosyltransferase 1-3
Gene Name	UGT1A3
Actions	substrate
References	Watanabe Y, Nakajima M, Yokoi T: Troglitazone glucuronidation in human liver and intestine microsomes: high catalytic activity of UGT1A8 and UGT1A10. Drug Metab Dispos. 2002 Dec;30(12):1462-9. - Pubmed
DTHybrid score	0.4671
UDP-glucuronosyltransferase 1-4
Name	UDP-glucuronosyltransferase 1-4
Gene Name	UGT1A4
Actions	substrate
References	Watanabe Y, Nakajima M, Yokoi T: Troglitazone glucuronidation in human liver and intestine microsomes: high catalytic activity of UGT1A8 and UGT1A10. Drug Metab Dispos. 2002 Dec;30(12):1462-9. - Pubmed
DTHybrid score	0.2879
UDP-glucuronosyltransferase 1-6
Name	UDP-glucuronosyltransferase 1-6
Gene Name	Not Available
Actions	substrate,inhibitor
References	Watanabe Y, Nakajima M, Yokoi T: Troglitazone glucuronidation in human liver and intestine microsomes: high catalytic activity of UGT1A8 and UGT1A10. Drug Metab Dispos. 2002 Dec;30(12):1462-9. - Pubmed Ito M, Yamamoto K, Sato H, Fujiyama Y, Bamba T: Inhibitory effect of troglitazone on glucuronidation catalyzed by human uridine diphosphate-glucuronosyltransferase 1A6. Eur J Clin Pharmacol. 2001 Mar;56(12):893-5. - Pubmed
DTHybrid score	Not Available
UDP-glucuronosyltransferase 1-7
Name	UDP-glucuronosyltransferase 1-7
Gene Name	Not Available
Actions	substrate
References	Watanabe Y, Nakajima M, Yokoi T: Troglitazone glucuronidation in human liver and intestine microsomes: high catalytic activity of UGT1A8 and UGT1A10. Drug Metab Dispos. 2002 Dec;30(12):1462-9. - Pubmed
DTHybrid score	Not Available
UDP-glucuronosyltransferase 1-8
Name	UDP-glucuronosyltransferase 1-8
Gene Name	UGT1A8
Actions	substrate
References	Watanabe Y, Nakajima M, Yokoi T: Troglitazone glucuronidation in human liver and intestine microsomes: high catalytic activity of UGT1A8 and UGT1A10. Drug Metab Dispos. 2002 Dec;30(12):1462-9. - Pubmed
DTHybrid score	0.2763
UDP-glucuronosyltransferase 1-9
Name	UDP-glucuronosyltransferase 1-9
Gene Name	UGT1A9
Actions	substrate
References	Watanabe Y, Nakajima M, Yokoi T: Troglitazone glucuronidation in human liver and intestine microsomes: high catalytic activity of UGT1A8 and UGT1A10. Drug Metab Dispos. 2002 Dec;30(12):1462-9. - Pubmed Barbier O, Villeneuve L, Bocher V, Fontaine C, Torra IP, Duhem C, Kosykh V, Fruchart JC, Guillemette C, Staels B: The UDP-glucuronosyltransferase 1A9 enzyme is a peroxisome proliferator-activated receptor alpha and gamma target gene. J Biol Chem. 2003 Apr 18;278(16):13975-83. Epub 2003 Feb 11. - Pubmed
DTHybrid score	0.4869
UDP-glucuronosyltransferase 1-10
Name	UDP-glucuronosyltransferase 1-10
Gene Name	UGT1A10
Actions	substrate
References	Watanabe Y, Nakajima M, Yokoi T: Troglitazone glucuronidation in human liver and intestine microsomes: high catalytic activity of UGT1A8 and UGT1A10. Drug Metab Dispos. 2002 Dec;30(12):1462-9. - Pubmed
DTHybrid score	0.2742
UDP-glucuronosyltransferase 2B7
Name	UDP-glucuronosyltransferase 2B7
Gene Name	UGT2B7
Actions	substrate
References	Watanabe Y, Nakajima M, Yokoi T: Troglitazone glucuronidation in human liver and intestine microsomes: high catalytic activity of UGT1A8 and UGT1A10. Drug Metab Dispos. 2002 Dec;30(12):1462-9. - Pubmed
DTHybrid score	0.4641
UDP-glucuronosyltransferase 2B15
Name	UDP-glucuronosyltransferase 2B15
Gene Name	Not Available
Actions	substrate
References	Watanabe Y, Nakajima M, Yokoi T: Troglitazone glucuronidation in human liver and intestine microsomes: high catalytic activity of UGT1A8 and UGT1A10. Drug Metab Dispos. 2002 Dec;30(12):1462-9. - Pubmed
DTHybrid score	Not Available

Bile salt export pump
Name	Bile salt export pump
Gene Name	ABCB11
Actions	inhibitor
References	Wang EJ, Casciano CN, Clement RP, Johnson WW: Fluorescent substrates of sister-P-glycoprotein (BSEP) evaluated as markers of active transport and inhibition: evidence for contingent unequal binding sites. Pharm Res. 2003 Apr;20(4):537-44. - Pubmed Funk C, Pantze M, Jehle L, Ponelle C, Scheuermann G, Lazendic M, Gasser R: Troglitazone-induced intrahepatic cholestasis by an interference with the hepatobiliary export of bile acids in male and female rats. Correlation with the gender difference in troglitazone sulfate formation and the inhibition of the canalicular bile salt export pump (Bsep) by troglitazone and troglitazone sulfate. Toxicology. 2001 Oct 5;167(1):83-98. - Pubmed Saito H, Osumi M, Hirano H, Shin W, Nakamura R, Ishikawa T: Technical pitfalls and improvements for high-speed screening and QSAR analysis to predict inhibitors of the human bile salt export pump (ABCB11/BSEP). AAPS J. 2009 Sep;11(3):581-9. Epub 2009 Aug 18. - Pubmed
DTHybrid score	0.2491
Solute carrier organic anion transporter family member 1B1
Name	Solute carrier organic anion transporter family member 1B1
Gene Name	SLCO1B1
Actions	inhibitor
References	Nozawa T, Sugiura S, Nakajima M, Goto A, Yokoi T, Nezu J, Tsuji A, Tamai I: Involvement of organic anion transporting polypeptides in the transport of troglitazone sulfate: implications for understanding troglitazone hepatotoxicity. Drug Metab Dispos. 2004 Mar;32(3):291-4. - Pubmed
DTHybrid score	0.423

Id	Partner name	Gene Name	Score
1588	Multidrug resistance protein 1	ABCB1	0.5686
4200	Cytochrome P450 1A2	CYP1A2	0.5037
4119	Cytochrome P450 2D6	CYP2D6	0.5016
20	Prostaglandin G/H synthase 1	PTGS1	0.3134
587	Serum albumin	ALB	0.2781
6013	Cytochrome P450 2E1	CYP2E1	0.2588
5718	Cytochrome P450 2A6	CYP2A6	0.2568
791	Urokinase plasminogen activator surface receptor	PLAUR	0.2449
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.2304
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.2261
1729	Solute carrier family 22 member 6	SLC22A6	0.2173
234	Plasminogen	PLG	0.2094
595	Fibrinogen alpha chain	FGA	0.2089
290	Prostaglandin G/H synthase 2	PTGS2	0.1992
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.1774
6243	Nuclear receptor-interacting protein 1	NRIP1	0.1619
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.1612
862	Multidrug resistance-associated protein 1	ABCC1	0.1342
6106	Cytochrome P450 2C18	CYP2C18	0.1243
2164	Multidrug resistance-associated protein 4	ABCC4	0.1087
6142	Solute carrier family 22 member 8	SLC22A8	0.1086
1898	Cytochrome P450 1B1	CYP1B1	0.1046
146	Androgen receptor	AR	0.0955
136	Estrogen receptor	ESR1	0.0953
847	Mu-type opioid receptor	OPRM1	0.0914
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0895
3755	Nucleoside-specific channel-forming protein tsx precursor	tsx	0.085
6145	Solute carrier family 22 member 1	SLC22A1	0.085
6143	Solute carrier family 22 member 7	SLC22A7	0.0848
4773	Deoxycytidine kinase	DCK	0.0843
1181	Alpha-1-acid glycoprotein 1	ORM1	0.0832
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.083
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0813
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0813
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0804
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.08
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0795
467	Delta-type opioid receptor	OPRD1	0.0789
4604	Liver carboxylesterase 1	CES1	0.0786
492	Histamine H1 receptor	HRH1	0.0776
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0758
696	Kappa-type opioid receptor	OPRK1	0.0749
6141	Sodium/bile acid cotransporter	SLC10A1	0.0736
70	Type-1 angiotensin II receptor	AGTR1	0.0714
6171	Solute carrier family 28 member 3	SLC28A3	0.0695
6144	Solute carrier family 22 member 2	SLC22A2	0.0687
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0674
459	Retinoic acid receptor RXR-alpha	RXRA	0.067
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0641
6148	Multidrug resistance-associated protein 7	ABCC10	0.0635
6031	Cytochrome P450 3A43	CYP3A43	0.0635
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.0634
6102	Arylamine N-acetyltransferase 2	NAT2	0.0625
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0615
824	Sodium-dependent serotonin transporter	SLC6A4	0.0611
1349	Plasminogen activator inhibitor 2	SERPINB2	0.0599
260	Cytochrome P450 51	ERG11	0.0589
761	Cytochrome P450 51	ERG11	0.0589
3163	Cytochrome P450 51	cyp51	0.0589
3833	Plasma serine protease inhibitor	SERPINA5	0.0573
3810	Catechol O-methyltransferase	COMT	0.0566
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0552
1818	Long-chain-fatty-acid--CoA ligase 3	ACSL3	0.0545
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0545
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0538
831	D(2) dopamine receptor	DRD2	0.0537
556	Alpha-1A adrenergic receptor	ADRA1A	0.0525
759	Free fatty acid receptor 1	FFAR1	0.0522
118	Organic cation/carnitine transporter 2	SLC22A5	0.052
1024	Solute carrier family 22 member 11	SLC22A11	0.051
373	Transthyretin	TTR	0.0497
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.0491
756	Sex hormone-binding globulin	SHBG	0.048
871	Glucocorticoid receptor	NR3C1	0.0479
468	Cytochrome P450 4A11	CYP4A11	0.0478
6136	Multidrug resistance-associated protein 5	ABCC5	0.0475
6228	Nuclear receptor coactivator 1	NCOA1	0.0462
4164	Potassium voltage-gated channel subfamily KQT member 5	KCNQ5	0.0448
4163	Potassium voltage-gated channel subfamily KQT member 4	KCNQ4	0.0448
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0445
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0443
738	Monocarboxylate transporter 1	SLC16A1	0.0442
2021	Thrombomodulin	THBD	0.0439
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0438
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0437
731	HIV-1 protease	HIV-1 protease	0.0433
1053	BC269730_2	FADS1	0.0429
1395	Sodium/calcium exchanger 1	SLC8A1	0.0429
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0418
5880	Thrombopoietin receptor	MPL	0.0417
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0413
275	Arachidonate 5-lipoxygenase	ALOX5	0.0412
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0412
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0412
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0411
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0409
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.0408
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0406
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0405
1039	Histone deacetylase 9	HDAC9	0.0401
6147	Solute carrier family 22 member 3	SLC22A3	0.0401
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0401
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0397
869	Estrogen receptor beta	ESR2	0.0393
1558	Transient receptor potential cation channel subfamily V member 1	TRPV1	0.0391
320	5-hydroxytryptamine 1A receptor	HTR1A	0.039
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0388
24	Thymidylate synthase	TMP1	0.0383
359	Thymidylate synthase	TYMS	0.0383
2626	Thymidylate synthase	thyA	0.0383
2729	Thymidylate synthase	thyA	0.0383
5352	Thymidylate synthase	THYA	0.0383
766	Beta-2 adrenergic receptor	ADRB2	0.0379
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0379
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0372
1792	Tissue-type plasminogen activator	PLAT	0.0369
504	Mast/stem cell growth factor receptor	KIT	0.0365
26	Vascular endothelial growth factor receptor 3	FLT4	0.0364
3947	Xanthine dehydrogenase/oxidase	XDH	0.0363
465	Calmodulin	CALM1	0.036
3834	Nidogen-1	NID1	0.0359
318	Alpha-2A adrenergic receptor	ADRA2A	0.0353
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.035
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.035
3312	Fatty acid-binding protein, brain	FABP7	0.0349
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0349
32	Vascular endothelial growth factor receptor 1	FLT1	0.0348
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0346
856	Vitamin D3 receptor	VDR	0.0344
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0343
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0338
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0337
407	Vascular endothelial growth factor receptor 2	KDR	0.0336
1192	Sulfotransferase 1A1	SULT1A1	0.0331
277	Purine nucleoside phosphorylase	PNP	0.033
2870	Purine nucleoside phosphorylase	punA	0.033
2945	Purine nucleoside phosphorylase	punA	0.033
4659	Purine nucleoside phosphorylase	TM_1596	0.033
4825	Purine nucleoside phosphorylase	TTHA1435	0.033
632	Alpha-1B adrenergic receptor	ADRA1B	0.0329
614	Progesterone receptor	PGR	0.0329
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0328
817	DNA topoisomerase 2-alpha	TOP2A	0.0327
3830	Calreticulin	CALR	0.0327
3825	Tetranectin	CLEC3B	0.0327
2111	Annexin A2	ANXA2	0.0326
3826	Keratin, type II cytoskeletal 8	KRT8	0.0326
3611	Cytidine deaminase	cdd	0.0323
3707	Cytidine deaminase	cdd	0.0323
4211	Cytidine deaminase	CDA	0.0323
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0322
3941	Amine oxidase [flavin-containing] A	MAOA	0.0319
23	D(1A) dopamine receptor	DRD1	0.0318
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0314
833	Organic cation/carnitine transporter 1	SLC22A4	0.0308
3011	Suppressor of tumorigenicity protein 14	ST14	0.0305
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0304
638	D(3) dopamine receptor	DRD3	0.0303
713	Sodium-dependent dopamine transporter	SLC6A3	0.03
3865	Serpin B6	SERPINB6	0.03
1959	Platelet factor 4	PF4	0.03
1986	Ceruloplasmin	CP	0.0299
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0299
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0297
1757	Myeloperoxidase	MPO	0.0297
6137	Multidrug resistance-associated protein 6	ABCC6	0.0297
4116	Dihydropteroate synthetase	Not Available	0.0296
563	Thyroid peroxidase	TPO	0.0292
54	Prothrombin	F2	0.029
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.029
6044	Serum paraoxonase/lactonase 3	PON3	0.029
811	Translocator protein	TSPO	0.0289
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0289
603	DNA polymerase alpha catalytic subunit	POLA1	0.0285
1516	Calnexin	CANX	0.0284
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0284
6020	Aldehyde oxidase	AOX1	0.0283
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0282
6241	Nuclear receptor coactivator 2	NCOA2	0.028
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0279
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0273
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0271
1244	Low-density lipoprotein receptor-related protein 2	LRP2	0.0268
6182	Cytochrome P450 2J2	CYP2J2	0.0266
6026	Alcohol dehydrogenase 6	ADH6	0.0266
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0265
3923	Cholinesterase	BCHE	0.0265
122	P2Y purinoceptor 12	P2RY12	0.0263
6220	Aryl hydrocarbon receptor	AHR	0.0263
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0263
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0262
3831	Low-density lipoprotein receptor-related protein 1	LRP1	0.0262
19	Coagulation factor VIII	F8	0.026
46	Coagulation factor V	F5	0.0254
2072	Endothelial protein C receptor	PROCR	0.0253
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0252
844	Epidermal growth factor receptor	EGFR	0.0251
380	Cytochrome P450 17A1	CYP17A1	0.0251
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0248
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0248
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0246
1245	Vitamin K-dependent protein S	PROS1	0.0246
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0246
629	Alpha-2B adrenergic receptor	ADRA2B	0.0244
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0243
1010	Cytochrome P450 51A1	CYP51A1	0.024
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0238
365	Dihydrofolate reductase	DHFR	0.0237
2381	Dihydrofolate reductase	DFR1	0.0237
2833	Dihydrofolate reductase	Not Available	0.0237
2931	Dihydrofolate reductase	folA	0.0237
3544	Dihydrofolate reductase	folA	0.0237
3682	Dihydrofolate reductase	folA	0.0237
6642	Dihydrofolate reductase	folA	0.0237
6756	Dihydrofolate reductase	dfrA	0.0237
891	Dihydropteroate synthase	folP	0.0237
5359	Dihydropteroate synthase	folP	0.0237
7175	Dihydropteroate synthase	sulI	0.0237
3939	Amine oxidase [flavin-containing] B	MAOB	0.0234
723	Cytosolic phospholipase A2	PLA2G4A	0.0234
6085	Fatty acid-binding protein, intestinal	FABP2	0.0232
3587	Gastrotropin	FABP6	0.0231
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.023
311	RNA-directed RNA polymerase catalytic subunit	PB1	0.0227
752	Large structural protein	L	0.0227
1043	Trifunctional purine biosynthetic protein adenosine-3 [Includes: Phosphoribosylamine--glycine ligase	GART	0.0225
1630	Integrin beta-2	ITGB2	0.0225
193	Beta-1 adrenergic receptor	ADRB1	0.0225
1050	Bile salt sulfotransferase	SULT2A1	0.0225
273	Apoptosis regulator Bcl-2	BCL2	0.0223
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0221
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0221
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0221
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0221
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0219
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0219
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0219
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0219
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0216
29	Tubulin beta-1 chain	TUBB1	0.0216
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0215
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0215
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0214
1275	Estrogen sulfotransferase	SULT1E1	0.0212
289	Cytosolic purine 5'-nucleotidase	NT5C2	0.0212
1760	Aminopeptidase N	ANPEP	0.021
6843	Aminopeptidase N	pepN	0.021
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.021
448	Vitamin K-dependent gamma-carboxylase	GGCX	0.0209
49	Endothelin B receptor	EDNRB	0.0209
117	Sterol O-acyltransferase 1	SOAT1	0.0205
789	Alpha-1D adrenergic receptor	ADRA1D	0.0205
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.0204
737	Mineralocorticoid receptor	NR3C2	0.0204
4120	NADPH--cytochrome P450 reductase	POR	0.0204
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0203
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0202
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.0202
226	Gonadotropin-releasing hormone receptor	GNRHR	0.02
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0197
578	Endothelin-1 receptor	EDNRA	0.0197
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0196
378	Alpha-2C adrenergic receptor	ADRA2C	0.0195
6014	Cytochrome P450 2A13	CYP2A13	0.0192
3866	Serum amyloid A protein	SAA1	0.019
1200	AMBP protein	AMBP	0.019
1932	Apolipoprotein E	APOE	0.019
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.019
33	Cystine/glutamate transporter	SLC7A11	0.019
1656	CYP2B protein	CYP2B	0.0189
777	Tumor necrosis factor	TNF	0.0187
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0187
716	5-hydroxytryptamine 7 receptor	HTR7	0.0187
1830	5'-nucleotidase	NT5E	0.0182
2808	Chloramphenicol acetyltransferase 3	cat3	0.0182
432	D(4) dopamine receptor	DRD4	0.0182
6859	Protein S100-A4	S100A4	0.018
4148	Serine/threonine-protein kinase mTOR	MTOR	0.018
4122	Histone deacetylase 2	HDAC2	0.018
508	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	ENPP1	0.0179
1629	Transcription factor AP-1	JUN	0.0179
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0177
148	Lutropin-choriogonadotropic hormone receptor	LHCGR	0.0175
3937	Fatty-acid amide hydrolase	FAAH	0.0174
683	Potassium transporter	GK0582	0.0174
161	Tubulin beta chain	TUBB	0.0173
312	Tubulin beta chain	TUB2	0.0173
6021	Adenosine kinase	ADK	0.0173
124	Histamine H2 receptor	HRH2	0.0172
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0172
3233	Bile acid receptor	NR1H4	0.0171
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0171
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.017
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.017
125	DNA polymerase beta	POLB	0.017
1074	Urokinase-type plasminogen activator	PLAU	0.017
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0169
2539	Tubulin alpha-1 chain	TUBA4A	0.0167
6339	Ig kappa chain V-II region RPMI 6410	Not Available	0.0167
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0164
319	Opioid receptor, sigma 1	OPRS1	0.0164
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0163
823	Fibroblast growth factor receptor 2	FGFR2	0.0162
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0162
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.016
572	Integrin alpha-L	ITGAL	0.0159
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0158
952	Dipeptidyl peptidase 4	DPP4	0.0158
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0157
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0152
6138	Multidrug resistance protein 3	ABCB4	0.0151
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0151
165	FL cytokine receptor	FLT3	0.0151
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0148
6043	Putative G-protein coupled receptor 44	GPR44	0.0147
3671	7-alpha-hydroxysteroid dehydrogenase	hdhA	0.0146
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0145
588	Chromodomain-helicase-DNA-binding protein 1	CHD1	0.0144
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0144
702	UMP-CMP kinase	CMPK1	0.0144
427	Substance-P receptor	TACR1	0.0144
232	Corticosteroid-binding globulin	SERPINA6	0.0143
84	Nuclear receptor 0B1	NR0B1	0.0143
6500	Phospholipase A2	PLA2G1B	0.0142
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0141
818	50S ribosomal protein L10	rplJ	0.0141
2981	Phospholipase A2, membrane associated	PLA2G2A	0.014
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.014
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0139
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0139
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0139
5934	Cytochrome P450 26A1	CYP26A1	0.0136
6167	Organic solute transporter subunit beta	OSTB	0.0135
6166	Organic solute transporter subunit alpha	OSTA	0.0135
2391	Ferrochelatase	hemH	0.0128
6502	Ferrochelatase	DKFZp686P18130	0.0128
1591	Ferrochelatase, mitochondrial	FECH	0.0128
2449	Tubulin alpha-3 chain	TUBA1A	0.0126
88	Retinoic acid receptor RXR-beta	RXRB	0.0126
469	Annexin A1	ANXA1	0.0126
87	Hypoxanthine-guanine phosphoribosyltransferase	HPRT1	0.0125
3856	Fibroblast growth factor receptor 3	FGFR3	0.0125
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0124
1405	Thiopurine S-methyltransferase	TPMT	0.0123
703	NADPH azoreductase	azr	0.0122
94	5-hydroxytryptamine 4 receptor	HTR4	0.0121
1178	Adenosine A2a receptor	ADORA2A	0.0121
1618	High affinity nerve growth factor receptor	NTRK1	0.0119
3270	Elongation factor G	fusA	0.0119
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0117
174	Sigma 1-type opioid receptor	SIGMAR1	0.0117
5787	Angiopoietin-1 receptor	TEK	0.0117
758	Thyroid hormone receptor alpha	THRA	0.0116
1353	DNA topoisomerase 1	TOP1	0.0116
3552	DNA topoisomerase 1	topA	0.0116
48	Pyridoxal kinase	PDXK	0.0116
780	Retinoic acid receptor RXR-gamma	RXRG	0.0115
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0115
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0115
642	3-oxo-5-alpha-steroid 4-dehydrogenase 2	SRD5A2	0.0115
1852	Microtubule-associated protein 2	MAP2	0.0113
6103	Arylamine N-acetyltransferase 1	NAT1	0.0113
705	Glutamate receptor 1	GRIA1	0.0112
3932	Glutathione S-transferase A2	GSTA2	0.0112
5923	Microtubule-associated protein tau	MAPT	0.0112
5924	Microtubule-associated protein 4	MAP4	0.0112
768	FK506-binding protein 1A	FKBP1A	0.0112
295	Carbonic anhydrase 1	CA1	0.0112
6495	Cytochrome c oxidase subunit 7C, mitochondrial	COX7C	0.0111
6499	Cytochrome c oxidase polypeptide 7A1, mitochondrial	COX7A1	0.0111
6496	Cytochrome c oxidase subunit 8A, mitochondrial	COX8A	0.0111
6493	Cytochrome c oxidase subunit 6C	COX6C	0.0111
6494	Cytochrome c oxidase subunit 7B, mitochondrial	COX7B	0.0111
6498	Cytochrome c oxidase subunit 6B1	COX6B1	0.0111
5793	Cytochrome c oxidase subunit 2	MT-CO2	0.0111
6559	Cytochrome c oxidase subunit 2	ctaC	0.0111
6669	Cytochrome c oxidase subunit 2	ctaC	0.0111
6497	Cytochrome c oxidase subunit 6A2, mitochondrial	COX6A2	0.0111
6491	Cytochrome c oxidase subunit 5A, mitochondrial	COX5A	0.0111
6489	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	COX4I1	0.0111
6490	Cytochrome c oxidase subunit 3	MT-CO3	0.0111
371	Cytochrome c oxidase subunit 1	MT-CO1	0.011
6558	Cytochrome c oxidase subunit 1	ctaD	0.011
571	Melatonin receptor type 1A	MTNR1A	0.011
362	Melatonin receptor type 1B	MTNR1B	0.011
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.011
4226	Uridine phosphorylase 2	UPP2	0.011
284	DNA-directed RNA polymerase beta chain	rpoB	0.0109
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0109
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0109
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0108
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0108
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0106
921	Glutamate receptor 2	GRIA2	0.0106
482	Glycine receptor subunit alpha-1	GLRA1	0.0106
887	DNA gyrase subunit B	gyrB	0.0105
4150	DNA gyrase subunit B	gyrB	0.0105
6225	DNA gyrase subunit B	gyrB	0.0105
4132	Chloride channel protein ClC-Ka	CLCNKA	0.0104
346	Thyroid hormone receptor beta-1	THRB	0.0103
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0103
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0103
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0102
2540	Choloylglycine hydrolase	cbh	0.0102
6042	Prostaglandin reductase 2	PTGR2	0.0102
131	Synaptic vesicular amine transporter	SLC18A2	0.0102
1517	Beta-3 adrenergic receptor	ADRB3	0.0102
517	Alcohol dehydrogenase 1C	ADH1C	0.0102
4203	Histamine N-methyltransferase	HNMT	0.0101
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.01
162	Retinoic acid receptor gamma-1	RARG	0.01
4225	Uridine phosphorylase 1	UPP1	0.01
3957	Adenosine deaminase	ADA	0.0099
592	Carbonic anhydrase 4	CA4	0.0099
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0099
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0098
2499	Tubulin beta-2C chain	TUBB2C	0.0098
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0097
936	Ephrin type-A receptor 2	EPHA2	0.0096
6501	Fatty acid-binding protein, liver	FABP1	0.0096
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0096
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0096
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0096
3639	Thymidine phosphorylase	deoA	0.0096
3936	Thymidine phosphorylase	TYMP	0.0096
7	Nitric oxide synthase, inducible	NOS2	0.0095
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0095
634	Squalene monooxygenase	SQLE	0.0094
7196	Squalene monooxygenase	ERG1	0.0094
5798	Mitogen-activated protein kinase 11	MAPK11	0.0093
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0093
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0093
4192	DNA topoisomerase 2-beta	TOP2B	0.0091
413	Amidophosphoribosyltransferase	PPAT	0.0091
2515	Amidophosphoribosyltransferase	purF	0.0091
3714	Amidophosphoribosyltransferase	purF	0.0091
477	DNA topoisomerase 4 subunit A	parC	0.009
886	DNA topoisomerase 4 subunit A	parC	0.009
6226	DNA topoisomerase 4 subunit A	parC	0.009
613	Atrial natriuretic peptide receptor A	NPR1	0.009
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0089
404	DNA gyrase subunit A	gyrA	0.0089
6224	DNA gyrase subunit A	gyrA	0.0089
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0088
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0088
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0088
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0087
814	Ryanodine receptor 1	RYR1	0.0086
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0086
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0086
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0086
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0086
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0086
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0084
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0084
605	Fumarate reductase flavoprotein subunit	frdA	0.0083
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0083
3673	Fumarate reductase flavoprotein subunit	fccA	0.0083
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0083
6549	Fumarate reductase flavoprotein subunit	frdA	0.0083
594	Thyroxine-binding globulin	SERPINA7	0.0083
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0083
68	Cannabinoid receptor 1	CNR1	0.0083
5300	Antigen peptide transporter 1	TAP1	0.008
751	Potassium channel subfamily K member 6	KCNK6	0.008
1196	Complement decay-accelerating factor	CD55	0.008
489	Monocarboxylate transporter 2	SLC16A7	0.008
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0079
1313	Lactoylglutathione lyase	GLO1	0.0079
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0079
4311	tRNA	TRDMT1	0.0079
4325	tRNA	trmD	0.0079
4328	tRNA	trmD	0.0079
442	Envelope glycoprotein	gp41	0.0078
4859	Envelope glycoprotein	env	0.0078
474	Acetylcholinesterase	ACHE	0.0078
16	Adenosine A1 receptor	ADORA1	0.0078
1680	Solute carrier family 2, facilitated glucose transporter member 1	SLC2A1	0.0078
581	Cytochrome P450 2R1	CYP2R1	0.0077
820	Glycine receptor subunit alpha-2	GLRA2	0.0077
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0077
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0076
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0076
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0075
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0075
1541	Metalloproteinase	mmp20	0.0074
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0074
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0074
172	Potassium channel subfamily K member 1	KCNK1	0.0073
357	Carbonic anhydrase 2	CA2	0.0073
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0073
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0072
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0072
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0071
78	Acetyl-CoA acetyltransferase, mitochondrial	ACAT1	0.0071
2112	Toll-like receptor 9	TLR9	0.0071
1525	Heparin-binding growth factor 2	FGF2	0.007
164	Histamine H4 receptor	HRH4	0.007
976	Platelet glycoprotein IX	GP9	0.007
239	Coagulation factor X	F10	0.007
1649	Small inducible cytokine A2	CCL2	0.007
183	Vascular endothelial growth factor A	VEGFA	0.0069
4237	50S ribosomal protein L22	rplV	0.0068
1650	Heme carrier protein 1	SLC46A1	0.0068
1483	Membrane copper amine oxidase	AOC3	0.0067
4217	Telomerase reverse transcriptase	TERT	0.0067
229	Retinoic acid receptor beta	RARB	0.0067
569	Retinal dehydrogenase 2	ALDH1A2	0.0067
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0066
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0066
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0066
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0066
730	Retinoic acid receptor alpha	RARA	0.0066
6146	High affinity copper uptake protein 1	SLC31A1	0.0065
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0065
904	Glutathione S-transferase P	GSTP1	0.0065
6034	Hydroxyindole O-methyltransferase	ASMT	0.0064
6035	Nuclear receptor ROR-beta	RORB	0.0064
6036	Eosinophil peroxidase	EPX	0.0064
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0064
3601	Dihydropteroate synthase 1	folP1	0.0063
3807	Dihydropteroate synthase 1	folP1	0.0063
3808	Dihydropteroate synthase 2	folP2	0.0063
2417	Chloramphenicol acetyltransferase	cat	0.0063
3278	Chloramphenicol acetyltransferase	cat	0.0063
1992	Vitamin D-binding protein	GC	0.0063
719	Retinoic acid receptor responder protein 1	RARRES1	0.0063
770	Retinoic acid-induced protein 3	GPRC5A	0.0063
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0063
686	Aldo-keto reductase family 1 member C2	AKR1C2	0.0063
133	Dihydropterate synthase	sulI	0.0063
611	Retinal dehydrogenase 1	ALDH1A1	0.0062
2810	Dr hemagglutinin structural subunit	draA	0.0062
6105	3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	0.0062
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0062
6126	Carbonic anhydrase 7	CA7	0.0062
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0062
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0062
6174	50S ribosomal protein L32	rpmF	0.0061
908	Glutathione S-transferase theta-1	GSTT1	0.006
163	D(1B) dopamine receptor	DRD5	0.006
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0059
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0059
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0059
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0059
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0059
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0058
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0058
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0058
790	DNA polymerase subunit alpha B	POLA2	0.0058
2216	Fibroblast growth factor receptor 4	FGFR4	0.0058
153	Dopamine beta-hydroxylase	DBH	0.0057
106	Cannabinoid receptor 2	CNR2	0.0057
765	Indoleamine 2,3-dioxygenase	IDO1	0.0056
144	Hemoglobin subunit alpha	HBA1	0.0056
6168	Solute carrier family 22 member 16	SLC22A16	0.0055
558	Solute carrier family 12 member 1	SLC12A1	0.0054
4228	Keratin, type II cytoskeletal 7	KRT7	0.0054
4238	50S ribosomal protein L4	rplD	0.0054
5578	50S ribosomal protein L4	rplD	0.0054
6173	50S ribosomal protein L4	rplD	0.0054
6219	50S ribosomal protein L4	rplD	0.0054
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0054
3086	Plasmepsin-2	Not Available	0.0053
199	Monocarboxylate transporter 8	SLC16A2	0.0053
2320	Thymidine kinase, cytosolic	TK1	0.0052
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0052
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0052
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0052
3426	Glutamine synthetase	glnA	0.0052
3987	Glutamine synthetase	GLUL	0.0052
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.0052
3913	Glutamic acid decarboxylase	GAD65	0.0052
4752	Peroxisomal trans-2-enoyl-CoA reductase	PECR	0.0052
2751	Holliday junction ATP-dependent DNA helicase ruvB	ruvB	0.0052
4755	Holliday junction ATP-dependent DNA helicase ruvB	ruvB	0.0052
760	Fibroblast growth factor 1	FGF1	0.0052
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.0051
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0051
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0051
6211	Tubulin epsilon chain	TUBE1	0.0051
6212	Tubulin gamma-1 chain	TUBG1	0.0051
6210	Tubulin delta chain	TUBD1	0.0051
6824	Tyrosine-protein kinase Lyn	LYN	0.005
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.005
518	Peroxidase/catalase T	katG	0.005
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0048
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0048
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.0048
6288	Low molecular weight phosphotyrosine protein phosphatase	ACP1	0.0048
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0047
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0047
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0047
6832	Serine/threonine-protein kinase SRPK2	SRPK2	0.0046
1648	Elastin	ELN	0.0046
1714	Mitogen-activated protein kinase 3	MAPK3	0.0046
4103	Proteasome subunit beta type 2	PSMB2	0.0045
4102	Proteasome subunit beta type 5	PSMB5	0.0045
4101	Proteasome subunit beta type 1	PSMB1	0.0045
527	Prostacyclin receptor	PTGIR	0.0045
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0044
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0044
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0044
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0044
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0044
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0044
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0044
251	Alcohol dehydrogenase 1A	ADH1A	0.0044
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0044
130	Prostacyclin synthase	PTGIS	0.0044
1820	Beta-nerve growth factor	NGF	0.0044
3904	Alanine aminotransferase 2	GPT2	0.0043
735	Alanine aminotransferase 1	GPT	0.0043
4692	A/G-specific adenine glycosylase	mutY	0.0043
461	Glycine receptor subunit alpha-3	GLRA3	0.0043
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0043
6432	Transporter	snf	0.0042
291	Nitric-oxide synthase, endothelial	NOS3	0.0042
4606	Purine trans deoxyribosylase	ptd	0.0042
1176	Mitogen-activated protein kinase 1	MAPK1	0.0041
3679	MTA/SAH nucleosidase	mtnN	0.004
1958	S-methyl-5-thioadenosine phosphorylase	MTAP	0.004
6766	O-GlcNAcase BT_4395	BT_4395	0.004
775	Acetyl-CoA carboxylase 2	ACACB	0.004
484	Tyrosine-protein kinase ABL2	ABL2	0.004
6149	Solute carrier family 22 member 10	SLC22A10	0.0039
2268	Cholesterol oxidase	choB	0.0039
2822	Cholesterol oxidase	choA	0.0039
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0039
444	Alcohol dehydrogenase 1B	ADH1B	0.0039
4146	Phosphatidylinositol 3-kinase regulatory subunit gamma	PIK3R3	0.0039
4145	Phosphatidylinositol 3-kinase regulatory subunit beta	PIK3R2	0.0039
1129	C-C chemokine receptor type 5	CCR5	0.0039
128	Adenine phosphoribosyltransferase	APRT	0.0038
6048	Troponin C, skeletal muscle	TNNC2	0.0038
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0038
85	Growth hormone receptor	GHR	0.0038
2283	Steroid Delta-isomerase	ksi	0.0037
2920	Steroid Delta-isomerase	ksi	0.0037
2782	Complement C1s subcomponent	C1S	0.0037
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0036
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0036
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0036
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0036
633	Penicillin-binding proteins 1A/1B	pbpA	0.0036
1262	Corticotropin-lipotropin	POMC	0.0035
185	Vasopressin V1a receptor	AVPR1A	0.0035
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0035
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.0035
939	50S ribosomal protein L3	rplC	0.0035
3815	Complement C1q subcomponent subunit A	C1QA	0.0034
3816	Complement C1q subcomponent subunit B	C1QB	0.0034
322	Vasopressin V2 receptor	AVPR2	0.0034
3817	Complement C1q subcomponent subunit C	C1QC	0.0034
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0034
3818	Low affinity immunoglobulin gamma Fc region receptor III-A	FCGR3A	0.0034
3819	Low affinity immunoglobulin gamma Fc region receptor II-a	FCGR2A	0.0034
1102	Low affinity immunoglobulin gamma Fc region receptor III-B	FCGR3B	0.0034
3821	Low affinity immunoglobulin gamma Fc region receptor II-c	FCGR2C	0.0034
3814	Complement C1r subcomponent	C1R	0.0034
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.0034
3820	Low affinity immunoglobulin gamma Fc region receptor II-b	FCGR2B	0.0034
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0033
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0033
1281	Phosphatidylinositol 3-kinase regulatory subunit alpha	PIK3R1	0.0033
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0032
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.0032
784	High affinity immunoglobulin gamma Fc receptor I	FCGR1A	0.0032
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0032
1770	Phospholipase C	PLCL1	0.0032
2841	Phospholipase C	plc	0.0032
1864	RET proto-oncogene	RET	0.0032
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0032
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0032
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0032
140	30S ribosomal protein S9	rpsI	0.0031
6719	30S ribosomal protein S9	rpsI	0.0031
6725	30S ribosomal protein S9	rpsI	0.0031
268	Adenosine A2b receptor	ADORA2B	0.0031
2236	Casein kinase II subunit alpha	CSNK2A1	0.0031
1227	Cytochrome b	MT-CYB	0.0031
6386	Cytochrome b	petB	0.0031
6937	Cytochrome b	MT-CYB	0.0031
674	Dihydroorotate dehydrogenase homolog, mitochondrial	PFF0160c	0.0031
2264	Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	cobT	0.0031
6151	Monocarboxylate transporter 10	SLC16A10	0.0031
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.003
1063	Signal transducer and activator of transcription 5B	STAT5B	0.003
2578	Tubulin beta-3 chain	TUBB3	0.003
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.003
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.003
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.003
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.003
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.003
2285	Streptogramin A acetyltransferase	vatD	0.003
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.003
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.003
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.003
636	Mitochondrial carnitine/acylcarnitine carrier protein	SLC25A20	0.0029
109	Mitochondrial carnitine/acylcarnitine carrier protein CACL	SLC25A29	0.0029
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0029
1569	G1/S-specific cyclin-D1	CCND1	0.0029
424	Dihydroorotate dehydrogenase, mitochondrial	DHODH	0.0029
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0029
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0028
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0028
1374	Natriuretic peptides B	NPPB	0.0028
1827	Gap junction alpha-1 protein	GJA1	0.0028
1908	Vascular cell adhesion protein 1	VCAM1	0.0028
1144	Hepatocyte growth factor receptor	MET	0.0027
4173	Tyrosine-protein kinase JAK2	JAK2	0.0027
896	Glutathione S-transferase Mu 1	GSTM1	0.0027
2159	Quinone oxidoreductase	CRYZ	0.0027
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0026
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0026
6131	Carbonic anhydrase 14	CA14	0.0026
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0026
412	Peroxisomal carnitine O-octanoyltransferase	CROT	0.0026
551	Carnitine O-acetyltransferase	CRAT	0.0025
6033	High affinity interleukin-8 receptor A	CXCR1	0.0025
6163	Copper-transporting ATPase 2	ATP7B	0.0024
6165	Copper-transporting ATPase 1	ATP7A	0.0024
544	Potassium voltage-gated channel subfamily E member 1	KCNE1	0.0024
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0024
6122	Carbonic anhydrase 3	CA3	0.0024
5852	Type-2 angiotensin II receptor	AGTR2	0.0024
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0023
76	Nitric-oxide synthase, brain	NOS1	0.0023
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0022
4209	ATP-sensitive inward rectifier potassium channel 8	KCNJ8	0.0022
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0022
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0022
2232	Interleukin-5	IL5	0.0022
298	Renin	REN	0.0021
1593	Mucin-2	MUC2	0.0021
6506	Stathmin-4	STMN4	0.0021
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.0021
340	Apoptotic protease-activating factor 1	APAF1	0.0021
3090	Chitosanase	csn	0.002
4149	Nuclear factor NF-kappa-B p100 subunit	NFKB2	0.002
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.002
6218	Pannexin-1	PANX1	0.0019
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0019
1291	cAMP response element-binding protein	CREB1	0.0019
233	Potassium channel subfamily K member 2	KCNK2	0.0019
2207	Rhodopsin	RHO	0.0019
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0018
1253	Interferon gamma	IFNG	0.0018
4210	Toll-like receptor 4	TLR4	0.0018
2105	ATP-binding cassette sub-family G member 1	ABCG1	0.0018
745	Anti-Muellerian hormone type-2 receptor	AMHR2	0.0018
825	Arsenical pump-driving ATPase	ASNA1	0.0018
3435	Arsenical pump-driving ATPase	arsA	0.0018
154	AFG3-like protein 2	AFG3L2	0.0018
486	Serine/threonine-protein kinase ALS2CR7	CDK15	0.0018
225	NEDD8-activating enzyme E1 regulatory subunit	NAE1	0.0018
510	Serine/threonine-protein kinase receptor R3	ACVRL1	0.0018
733	Activin receptor type 1B	ACVR1B	0.0018
483	A-Raf proto-oncogene serine/threonine-protein kinase	ARAF	0.0018
21	Beta-adrenergic receptor kinase 2	ADRBK2	0.0018
377	Beta-adrenergic receptor kinase 1	ADRBK1	0.0018
395	ALK tyrosine kinase receptor	Not Available	0.0018
5998	Toll-like receptor 8	TLR8	0.0018
712	Tubulin alpha chain	TUB1	0.0018
1968	ATP-sensitive inward rectifier potassium channel 12	KCNJ12	0.0018
565	Extracellular calcium-sensing receptor	CASR	0.0018
1123	Eosinophil cationic protein	RNASE3	0.0018
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0017
543	Penicillin-binding protein 1B	mrcB	0.0017
6186	Penicillin-binding protein 1B	ponB	0.0017
6822	Penicillin-binding protein 1b	pbp1b	0.0017
6844	Penicillin-binding protein 1b	pbp1b	0.0017
159	Penicillin-binding protein 2B	penA	0.0017
6121	Penicillin-binding protein 2B	penA	0.0017
400	Coagulation factor IX	F9	0.0017
5461	Coagulation factor IX	F9	0.0017
992	Protein tyrosine kinase 2 beta	PTK2B	0.0017
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0017
292	Activin receptor type-1	ACVR1	0.0017
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0017
1268	Neuropeptide S receptor	NPSR1	0.0017
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0017
849	Activated CDC42 kinase 1	TNK2	0.0017
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0016
3007	Carbonic anhydrase 12	CA12	0.0016
4205	Carbonic anhydrase 9	CA9	0.0016
821	Acetyl-coenzyme A synthetase 2-like, mitochondrial	ACSS1	0.0016
704	Long-chain-fatty-acid--CoA ligase 1	ACSL1	0.0016
386	Acetyl-coenzyme A synthetase, cytoplasmic	ACSS2	0.0016
297	Adenylate cyclase type 1	ADCY1	0.0016
173	Toll-like receptor 7	TLR7	0.0016
822	Aldose reductase	AKR1B1	0.0016
4081	Vitamin K epoxide reductase complex subunit 1-like protein 1	VKORC1L1	0.0015
604	Vitamin K-dependent protein Z	PROZ	0.0015
2853	14 kDa fatty acid-binding protein	Not Available	0.0015
6073	Potassium channel subfamily K member 9	KCNK9	0.0015
6072	Potassium channel subfamily K member 3	KCNK3	0.0015
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.0015
1341	Histamine H3 receptor	HRH3	0.0014
422	Vitamin K-dependent protein C	PROC	0.0014
2599	Tyrosine-protein kinase HCK	HCK	0.0014
5818	Folate receptor alpha	FOLR1	0.0014
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.0014
65	Matrix metalloproteinase-9	Not Available	0.0014
2300	Lysozyme	E	0.0014
3633	Lysozyme	R	0.0014
5597	Lysozyme	17	0.0014
740	Argininosuccinate synthase	ASS1	0.0013
865	Argininosuccinate synthase	ASS1	0.0013
2680	Argininosuccinate synthase	argG	0.0013
3194	Argininosuccinate synthase	argG	0.0013
661	ADP/ATP translocase 1	SLC25A4	0.0013
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0013
561	Retinol-binding protein II, cellular	RBP2	0.0013
35	Dehydrogenase/reductase SDR family member 4	DHRS4	0.0013
4073	Retinol dehydrogenase 11	RDH11	0.0013
4074	Retinol dehydrogenase 14	RDH14	0.0013
1097	Lecithin retinol acyltransferase	LRAT	0.0013
589	Retinoid-binding protein 7	RBP7	0.0013
753	Retinol-binding protein III, cellular	RBP5	0.0013
4071	Short-chain dehydrogenase/reductase 3	DHRS3	0.0013
4075	Photoreceptor outer segment all-trans retinol dehydrogenase	RDH8	0.0013
863	Cellular retinaldehyde-binding protein	RLBP1	0.0013
800	Retinol dehydrogenase 12	RDH12	0.0013
282	Interphotoreceptor retinoid-binding protein	RBP3	0.0013
651	Retinol dehydrogenase 13	RDH13	0.0013
4072	All-trans-retinol 13,14-reductase	RETSAT	0.0013
242	Asparagine synthetase [glutamine-hydrolyzing]	ASNS	0.0013
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0013
6116	Gastric triacylglycerol lipase	LIPF	0.0012
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0012
3823	Cytokine receptor common gamma chain	IL2RG	0.0012
293	Gamma-glutamyl hydrolase	GGH	0.0012
2107	Microtubule-associated protein 1A	MAP1A	0.0012
338	DNA polymerase	UL30	0.0012
379	DNA polymerase	UL54	0.0012
697	DNA polymerase	ORF28	0.0012
2482	DNA polymerase	43	0.0012
4104	DNA polymerase	BALF5	0.0012
997	Protein kinase C beta type	PRKCB	0.0012
4948	Cytochrome c-553	Not Available	0.0012
4923	Cytochrome c3	DvMF_2499	0.0012
4945	Cytochrome c3	Not Available	0.0012
4949	Cytochrome c3	DVU_3171	0.0012
4968	Cytochrome c3	cytc3	0.0012
4997	Cytochrome c3	SO_2727	0.0012
5219	Cytochrome c3	cyd	0.0012
1295	Fatty acid synthase	FASN	0.0012
4902	Nine-heme cytochrome c	Ddes_2038	0.0012
3189	High-molecular-weight cytochrome c	hmcA	0.0012
5433	UPF0230 protein TM_1468	TM_1468	0.0012
5431	Lipid binding protein	Not Available	0.0012
3616	Fatty acid-binding protein, epidermal	FABP5	0.0012
5430	Hepatocyte nuclear factor 4-gamma	HNF4G	0.0012
331	Retinol-binding protein I, cellular	RBP1	0.0012
627	11-cis retinol dehydrogenase	RDH5	0.0011
640	Aldehyde dehydrogenase 1A3	ALDH1A3	0.0011
798	Osteocalcin	BGLAP	0.0011
1970	Protein kinase C alpha type	PRKCA	0.0011
754	Pancreatic triacylglycerol lipase	PNLIP	0.0011
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0011
2408	Tyrosine-protein kinase SYK	SYK	0.0011
2178	Metabotropic glutamate receptor 5	GRM5	0.0011
724	Interleukin-2 receptor alpha chain	IL2RA	0.0011
717	Interleukin-2 receptor subunit beta	IL2RB	0.0011
1810	Protein S100-A1	S100A1	0.001
6097	Protein S100-A2	S100A2	0.001
4386	Hemoglobin-like protein HbN	glbN	0.001
369	Coagulation factor VII	F7	0.001
493	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	0.001
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.001
283	SEC14-like protein 2	SEC14L2	0.001
345	Plasma retinol-binding protein	RBP4	0.001
512	DNA-directed RNA polymerase alpha chain	rpoA	0.001
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.001
4041	Microsomal glutathione S-transferase 2	MGST2	0.001
6837	Serine/threonine-protein kinase 17B	STK17B	0.001
6836	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	HIBCH	0.001
2298	Cytochrome P450-cam	camC	0.001
5432	Trafficking protein particle complex subunit 3	TRAPPC3	0.0009
2211	Fatty acid-binding protein, heart	FABP3	0.0009
6459	Glycodelin	PAEP	0.0009
3221	Cytochrome c4	cc4	0.0009
828	Phenylalanine-4-hydroxylase	PAH	0.0009
3109	Phenylalanine-4-hydroxylase	phhA	0.0009
1048	Protein S100-A13	S100A13	0.0009
2226	Protein S100-A12	S100A12	0.0009
6677	Myelin P2 protein	PMP2	0.0009
390	Adenosine A3 receptor	ADORA3	0.0009
2132	Protein S100-B	S100B	0.0009
3404	Exotoxin A	eta	0.0008
6656	UDP-glucuronosyltransferase 3A1	UGT3A1	0.0008
22	30S ribosomal protein S4	rpsD	0.0008
6714	30S ribosomal protein S4	rpsD	0.0008
4954	Soluble cytochrome b558	Not Available	0.0008
4925	Cytochrome c-type protein SHP	shp	0.0008
4916	Cyanoglobin	glbN	0.0008
4947	Bacterial hemoglobin	vhb	0.0008
4915	Cytochrome c-550	psbV	0.0008
4959	Cytochrome c-550	psbV	0.0008
5216	Cytochrome c-550	psbV	0.0008
4934	Cytochrome c-551	nirM	0.0008
5218	Cytochrome c-551	nirM	0.0008
4943	Cytochrome c6	petJ	0.0008
4975	Cytochrome c-556	RPA3973	0.0008
4936	Cytochrome c2 iso-2	Not Available	0.0008
4994	Hemoglobin-like protein HbO	glbO	0.0008
4905	Cytochrome c2	Not Available	0.0008
4939	Cytochrome c2	cycA	0.0008
4964	Cytochrome c2	cycA	0.0008
4979	Cytochrome c2	cycA	0.0008
6673	Cytochrome c2	cycA	0.0008
4984	Neuroglobin	NGB	0.0008
4998	Hemoglobin-like protein yjbI	yjbI	0.0008
3116	Bacterioferritin	bfr	0.0008
4906	Bacterioferritin	bfr	0.0008
4965	Bacterioferritin	bfr	0.0008
5000	HemO	hemO	0.0008
4910	Cytoglobin	CYGB	0.0008
4909	CooA protein	cooA	0.0008
4981	Iron-starvation protein PigA	pigA	0.0008
4907	Cytochrome c-L	moxG	0.0008
6865	Cytochrome c-L	moxG	0.0008
644	Heme oxygenase 2	HMOX2	0.0008
4982	Heme oxygenase 2	pbsA2	0.0008
4942	Diheme cytochrome c napB	napB	0.0008
4935	Cytochrome c-554	cycA1	0.0008
4961	Hemophore HasA	hasA	0.0008
4904	Cytochrome c family protein	GSU1996	0.0008
4971	Nonaheme cytochrome c	hmcA	0.0008
4976	Apocytochrome f	petA	0.0008
6407	Apocytochrome f	petA	0.0008
4764	Cytochrome P450 165C4	CYP165C4	0.0008
4999	Cytochrome P450 165B3	CYP165B3	0.0008
4960	Putative cytochrome P450-family protein	SCO7417	0.0008
4931	Cytochrome P450 167A1	CYP167A1	0.0008
4989	Cytochrome c551 peroxidase	ccp	0.0008
5222	Cytochrome c551 peroxidase	ccpA	0.0008
4937	Cytochrome oxidase subunit II	rcoxA	0.0008
4972	P450cin	cinA	0.0008
4903	Methyl-accepting chemotaxis protein	Tar4	0.0008
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0008
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0008
4922	Cytochrome c, putative	SO_4144	0.0008
4993	Hydroxylamine oxidoreductase	hao1	0.0008
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0008
3093	Catalase HPII	katE	0.0008
4952	Catalase/peroxidase	katA	0.0008
1867	Major prion protein	PRNP	0.0008
1507	Cytochrome c	CYCS	0.0008
4031	Glutathione S-transferase A1	GSTA1	0.0008
6599	HTH-type transcriptional regulator ttgR	ttgR	0.0008
1025	Aquaporin-1	AQP1	0.0008
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0008
2091	Endoplasmin	HSP90B1	0.0008
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.0007
473	L-lactate dehydrogenase A chain	LDHA	0.0007
6263	cAMP-dependent protein kinase catalytic subunit alpha	PRKACA	0.0007
6344	ATP synthase subunit gamma, mitochondrial	ATP5C1	0.0007
6343	ATP synthase subunit beta, mitochondrial	ATP5B	0.0007
6342	ATP synthase subunit alpha, mitochondrial	ATP5A1	0.0007
6207	30S ribosomal protein S14	rpsN	0.0007
6209	30S ribosomal protein S19	rpsS	0.0007
6712	30S ribosomal protein S19	rpsS	0.0007
6726	30S ribosomal protein S19	rpsS	0.0007
6134	Sodium channel subunit beta-3	SCN3B	0.0007
6133	Sodium channel subunit beta-2	SCN2B	0.0007
6135	Sodium channel subunit beta-4	SCN4B	0.0007
6132	Sodium channel subunit beta-1	SCN1B	0.0007
6129	Carbonic anhydrase-related protein 11	CA11	0.0007
6127	Carbonic anhydrase-related protein	CA8	0.0007
6128	Carbonic anhydrase-related protein 10	CA10	0.0007
645	Penicillin-binding protein 1A	mrcA	0.0007
5805	Penicillin-binding protein 1A	ponA	0.0007
6185	Penicillin-binding protein 1A	mrcA	0.0007
6799	Penicillin-binding protein 1A	pbpA	0.0007
2290	ADP-ribosyl cyclase 2	BST1	0.0007
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0006
6259	(3R)-hydroxymyristoyl-acyl carrier protein dehydratase	fabZ	0.0006
6130	Carbonic anhydrase 13	CA13	0.0006
4920	Peroxidase/catalase	katG	0.0006
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0006
2119	Cytochrome b5	CYB5A	0.0006
4990	PpcA	ppcA	0.0006
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0006
3375	Acidic cytochrome c3	Not Available	0.0006
4988	Sulfite oxidase, mitochondrial	SUOX	0.0006
2915	Sensor protein fixL	fixL	0.0006
4944	Sensor protein fixL	fixL	0.0006
2404	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PIK3CG	0.0006
4385	Cytochrome c'	Not Available	0.0006
4967	Cytochrome c'	cycA	0.0006
5038	Cytochrome c'	Not Available	0.0006
5223	Cytochrome c'	cycP	0.0006
3570	Cytochrome P450 152A1	cypC	0.0006
4813	Heme oxygenase	hmuO	0.0006
5769	Heme oxygenase	Not Available	0.0006
4037	Hypothetical protein	GPX1	0.0006
4297	Hypothetical protein	SP_1951	0.0006
4521	Hypothetical protein	BC_2969	0.0006
4540	Hypothetical protein	TM_1070	0.0006
4555	Hypothetical protein	MT1739	0.0006
4569	Hypothetical protein	mshD	0.0006
4578	Hypothetical protein	PA3270	0.0006
4747	Hypothetical protein	PA3967	0.0006
5177	Hypothetical protein	TM_0096	0.0006
5194	Hypothetical protein	PA1204	0.0006
5240	Hypothetical protein	Rv2991	0.0006
5370	Hypothetical protein	TM_1158	0.0006
5710	Hypothetical protein	Tb927.5.1360	0.0006
4289	Cytochrome P450	TT_P0059	0.0006
6262	Cytochrome P450	staP	0.0006
4992	Cytochrome c peroxidase	Not Available	0.0006
2230	Catalase	CAT	0.0006
3249	Catalase	katA	0.0006
3625	Catalase	katA	0.0006
4539	Catalase	katA	0.0006
4941	Catalase	katB	0.0006
5221	Cytochrome c3, 13 kDa	Not Available	0.0006
3152	Cytochrome c''	cycA	0.0006
5220	Split-Soret cytochrome c	Ddes_2150	0.0006
3700	Cytochrome c-552 precursor	nrfA	0.0006
2347	Proto-oncogene serine/threonine-protein kinase Pim-1	PIM1	0.0005
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0005
3411	Cytochrome P450 121	cyp121	0.0005
3670	Soluble cytochrome b562 precursor	cybC	0.0005
244	Angiotensin-converting enzyme	ACE	0.0005
3291	Cytochrome c-552	cycA	0.0005
4927	Cytochrome c-552	nrfA	0.0005
4938	Cytochrome c-552	cycA	0.0005
4953	Cytochrome c-552	nrfA	0.0005
5217	Cytochrome c-552	cycM	0.0005
2617	Nitric oxide synthase oxygenase	nos	0.0005
2701	Nitric oxide synthase oxygenase	nos	0.0005
3102	Flavohemoprotein	hmp	0.0005
4969	Flavohemoprotein	hmp	0.0005
3127	Nitrite reductase	nirS	0.0005
3284	Nitrite reductase	nirS	0.0005
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0005
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0005
4608	Putative cytochrome P450	SCO1207	0.0004
4963	Putative cytochrome P450	SCO2884	0.0004
6254	Putative cytochrome P450	SCO6998	0.0004
3405	Quinohaemoprotein ethanol dehydrogenase type-1	qheDH	0.0004
358	Cystathionine beta-synthase	CBS	0.0004
693	Hemoglobin subunit beta	HBB	0.0004
6268	Hydroxyacid oxidase 1	HAO1	0.0004
810	Heme oxygenase 1	HMOX1	0.0004
3391	Heme oxygenase 1	pbsA1	0.0004
2240	Cell division protein kinase 2	CDK2	0.0003

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB00197 - Troglitazone

Targets

Enzymes

Transporters

Predictions