DT-Web

DB01412 - Theobromine


Identification
Name Theobromine
Accession Number DB01412
Type small molecule
Description 3,7-Dimethylxanthine. The principle alkaloid in Theobroma cacao (the cacao bean) and other plants. A xanthine alkaloid that is used as a bronchodilator and as a vasodilator. It has a weaker diuretic activity than theophylline and is also a less powerful stimulant of smooth muscle. It has practically no stimulant effect on the central nervous system. It was formerly used as a diuretic and in the treatment of angina pectoris and hypertension. (From Martindale, The Extra Pharmacopoeia, 30th ed, pp1318-9)
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 180.164
Groups approved
Monoisotopic Weight 180.06472552
Pharmacology
Indication theobromine is used as a vasodilator, a diuretic, and heart stimulant. And similar to caffeine, it may be useful in management of fatigue and orthostatic hypotension.
Mechanism of action Theobromine stimulates medullary, vagal, vasomotor, and respiratory centers, promoting bradycardia, vasoconstriction, and increased respiratory rate. This action was previously believed to be due primarily to increased intracellular cyclic 3′,5′-adenosine monophosphate (cyclic AMP) following inhibition of phosphodiesterase, the enzyme that degrades cyclic AMP. It is now thought that xanthines such as caffeine and theobromine act as antagonist at adenosine-receptors within the plasma membrane of virtually every cell. As adenosine acts as an autocoid, inhibiting the release of neurotransmitters from presynaptic sites but augmenting the actions of norepinephrine or angiotensin, antagonism of adenosine receptors promotes neurotransmitter release. This explains the stimulatory effects of xanthine derivatives such as theobromine and caffeine. Blockade of the adenosine A1 receptor in the heart leads to the accelerated, pronounced "pounding" of the heart upon caffeine intake.
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Adenosine A1 receptor
Name Adenosine A1 receptor
Gene Name ADORA1
Pharmacological action yes
Actions antagonist
References
  • Chou CC, Vickroy TW: Antagonism of adenosine receptors by caffeine and caffeine metabolites in equine forebrain tissues. Am J Vet Res. 2003 Feb;64(2):216-24. - Pubmed
  • Gaytan SP, Saadani-Makki F, Bodineau L, Frugiere A, Larnicol N, Pasaro R: Effect of postnatal exposure to caffeine on the pattern of adenosine A1 receptor distribution in respiration-related nuclei of the rat brainstem. Auton Neurosci. 2006 Jun 30;126-127:339-46. Epub 2006 May 15. - Pubmed
  • Wang SJ: Caffeine facilitation of glutamate release from rat cerebral cortex nerve terminals (synaptosomes) through activation protein kinase C pathway: an interaction with presynaptic adenosine A1 receptors. Synapse. 2007 Jun;61(6):401-11. - Pubmed
  • Rieg T, Schnermann J, Vallon V: Adenosine A1 receptors determine effects of caffeine on total fluid intake but not caffeine appetite. Eur J Pharmacol. 2007 Jan 26;555(2-3):174-7. Epub 2006 Oct 25. - Pubmed
  • Mustafa S, Venkatesh P, Pasha K, Mullangi R, Srinivas NR: Altered intravenous pharmacokinetics of topotecan in rats with acute renal failure (ARF) induced by uranyl nitrate: do adenosine A1 antagonists (selective/non-selective) normalize the altered topotecan kinetics in ARF? Xenobiotica. 2006 Dec;36(12):1239-58. - Pubmed
  • Listos J, Malec D, Fidecka S: Adenosine receptor antagonists intensify the benzodiazepine withdrawal signs in mice. Pharmacol Rep. 2006 Sep-Oct;58(5):643-51. - Pubmed
  • Fisone G, Borgkvist A, Usiello A: Caffeine as a psychomotor stimulant: mechanism of action. Cell Mol Life Sci. 2004 Apr;61(7-8):857-72. - Pubmed
  • Daly JW, Jacobson KA, Ukena D: Adenosine receptors: development of selective agonists and antagonists. Prog Clin Biol Res. 1987;230:41-63. - Pubmed
DTHybrid score 0.4648
Adenosine A2a receptor
Name Adenosine A2a receptor
Gene Name ADORA2A
Pharmacological action yes
Actions antagonist
References
  • Chou CC, Vickroy TW: Antagonism of adenosine receptors by caffeine and caffeine metabolites in equine forebrain tissues. Am J Vet Res. 2003 Feb;64(2):216-24. - Pubmed
  • Riksen NP, Franke B, van den Broek P, Smits P, Rongen GA: The 1976C>T polymorphism in the adenosine A2A receptor gene does not affect the vasodilator response to adenosine in humans in vivo. Pharmacogenet Genomics. 2007 Jul;17(7):551-4. - Pubmed
  • Zhao G, Messina E, Xu X, Ochoa M, Sun HL, Leung K, Shryock J, Belardinelli L, Hintze TH: Caffeine attenuates the duration of coronary vasodilation and changes in hemodynamics induced by regadenoson (CVT-3146), a novel adenosine A2A receptor agonist. J Cardiovasc Pharmacol. 2007 Jun;49(6):369-75. - Pubmed
  • Cornelis MC, El-Sohemy A, Campos H: Genetic polymorphism of the adenosine A2A receptor is associated with habitual caffeine consumption. Am J Clin Nutr. 2007 Jul;86(1):240-4. - Pubmed
  • Fisone G, Borgkvist A, Usiello A: Caffeine as a psychomotor stimulant: mechanism of action. Cell Mol Life Sci. 2004 Apr;61(7-8):857-72. - Pubmed
  • Daly JW, Jacobson KA, Ukena D: Adenosine receptors: development of selective agonists and antagonists. Prog Clin Biol Res. 1987;230:41-63. - Pubmed
DTHybrid score 0.7139
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
Name cAMP-specific 3',5'-cyclic phosphodiesterase 4B
Gene Name PDE4B
Pharmacological action unknown
Actions inhibitor
References
  • Essayan DM: Cyclic nucleotide phosphodiesterases. J Allergy Clin Immunol. 2001 Nov;108(5):671-80. - Pubmed
  • Fisone G, Borgkvist A, Usiello A: Caffeine as a psychomotor stimulant: mechanism of action. Cell Mol Life Sci. 2004 Apr;61(7-8):857-72. - Pubmed
  • Daly JW: Caffeine analogs: biomedical impact. Cell Mol Life Sci. 2007 Aug;64(16):2153-69. - Pubmed
  • Deree J, Martins JO, Melbostad H, Loomis WH, Coimbra R: Insights into the regulation of TNF-alpha production in human mononuclear cells: the effects of non-specific phosphodiesterase inhibition. Clinics (Sao Paulo). 2008 Jun;63(3):321-8. - Pubmed
DTHybrid score Not Available

Enzymes


Cytochrome P450 1A2
Name Cytochrome P450 1A2
Gene Name CYP1A2
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
  • Gates S, Miners JO: Cytochrome P450 isoform selectivity in human hepatic theobromine metabolism. Br J Clin Pharmacol. 1999 Mar;47(3):299-305. - Pubmed
DTHybrid score 0.3429
Cytochrome P450 2E1
Name Cytochrome P450 2E1
Gene Name CYP2E1
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.2549

Predictions


Id Partner name Gene Name Score
2358 cAMP-specific 3',5'-cyclic phosphodiesterase 4D PDE4D 0.255
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.2154
268 Adenosine A2b receptor ADORA2B 0.2116
4512 Cytochrome P450 3A4 CYP3A4 0.1535
4119 Cytochrome P450 2D6 CYP2D6 0.1115
4757 Cytochrome P450 2C9 CYP2C9 0.1057
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.1055
4109 cAMP-specific 3',5'-cyclic phosphodiesterase 4C PDE4C 0.1003
4122 Histone deacetylase 2 HDAC2 0.0868
6024 Cytochrome P450 1A1 CYP1A1 0.0838
6016 Cytochrome P450 2C19 CYP2C19 0.0837
390 Adenosine A3 receptor ADORA3 0.0791
4924 Cytochrome P450 2C8 CYP2C8 0.073
1588 Multidrug resistance protein 1 ABCB1 0.0661
1830 5'-nucleotidase NT5E 0.061
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0593
691 cAMP-specific 3',5'-cyclic phosphodiesterase 7B PDE7B 0.0582
6030 Cytochrome P450 2B6 CYP2B6 0.054
779 High-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A PDE7A 0.0534
4118 Cytochrome P450 3A5 CYP3A5 0.0506
3957 Adenosine deaminase ADA 0.0466
5718 Cytochrome P450 2A6 CYP2A6 0.0446
1898 Cytochrome P450 1B1 CYP1B1 0.0417
6107 Cytochrome P450 3A7 CYP3A7 0.0416
6143 Solute carrier family 22 member 7 SLC22A7 0.0415
6021 Adenosine kinase ADK 0.0413
2684 Histidine triad nucleotide-binding protein 1 HINT1 0.0408
6171 Solute carrier family 28 member 3 SLC28A3 0.037
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0318
777 Tumor necrosis factor TNF 0.0289
3811 Cytochrome P450 19A1 CYP19A1 0.0286
814 Ryanodine receptor 1 RYR1 0.0268
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0262
36 Insulin receptor INSR 0.0258
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0257
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0251
574 Branched-chain-amino-acid aminotransferase, cytosolic BCAT1 0.024
20 Prostaglandin G/H synthase 1 PTGS1 0.0228
492 Histamine H1 receptor HRH1 0.0222
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0203
587 Serum albumin ALB 0.0202
502 5-hydroxytryptamine 2A receptor HTR2A 0.016
290 Prostaglandin G/H synthase 2 PTGS2 0.0156
3923 Cholinesterase BCHE 0.0151
831 D(2) dopamine receptor DRD2 0.0151
3941 Amine oxidase [flavin-containing] A MAOA 0.0149
824 Sodium-dependent serotonin transporter SLC6A4 0.0148
556 Alpha-1A adrenergic receptor ADRA1A 0.0148
318 Alpha-2A adrenergic receptor ADRA2A 0.0148
144 Hemoglobin subunit alpha HBA1 0.0146
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.014
23 D(1A) dopamine receptor DRD1 0.0134
477 DNA topoisomerase 4 subunit A parC 0.0127
886 DNA topoisomerase 4 subunit A parC 0.0127
6226 DNA topoisomerase 4 subunit A parC 0.0127
1729 Solute carrier family 22 member 6 SLC22A6 0.0126
404 DNA gyrase subunit A gyrA 0.0125
6224 DNA gyrase subunit A gyrA 0.0125
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0123
6145 Solute carrier family 22 member 1 SLC22A1 0.0123
6106 Cytochrome P450 2C18 CYP2C18 0.0121
817 DNA topoisomerase 2-alpha TOP2A 0.012
442 Envelope glycoprotein gp41 0.012
4859 Envelope glycoprotein env 0.012
474 Acetylcholinesterase ACHE 0.0115
885 5-hydroxytryptamine 1B receptor HTR1B 0.0115
590 5-hydroxytryptamine 2C receptor HTR2C 0.0114
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0113
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0113
260 Cytochrome P450 51 ERG11 0.011
761 Cytochrome P450 51 ERG11 0.011
3163 Cytochrome P450 51 cyp51 0.011
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0103
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0103
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0103
3939 Amine oxidase [flavin-containing] B MAOB 0.0102
862 Multidrug resistance-associated protein 1 ABCC1 0.0102
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.01
341 5-hydroxytryptamine 3 receptor HTR3A 0.01
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.01
6144 Solute carrier family 22 member 2 SLC22A2 0.0099
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0099
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0098
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0098
958 Insulin-like growth factor 1 receptor IGF1R 0.0097
465 Calmodulin CALM1 0.0097
320 5-hydroxytryptamine 1A receptor HTR1A 0.0097
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0097
725 5-hydroxytryptamine 1D receptor HTR1D 0.0093
118 Organic cation/carnitine transporter 2 SLC22A5 0.0092
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0091
632 Alpha-1B adrenergic receptor ADRA1B 0.009
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0089
613 Atrial natriuretic peptide receptor A NPR1 0.0089
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0086
468 Cytochrome P450 4A11 CYP4A11 0.0085
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0085
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0084
6216 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A PDE8A 0.0083
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0082
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0082
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0082
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0081
6217 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B PDE8B 0.0081
136 Estrogen receptor ESR1 0.008
638 D(3) dopamine receptor DRD3 0.0078
482 Glycine receptor subunit alpha-1 GLRA1 0.0077
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0076
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0076
776 Bile salt export pump ABCB11 0.0075
789 Alpha-1D adrenergic receptor ADRA1D 0.0075
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0074
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0074
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0074
193 Beta-1 adrenergic receptor ADRB1 0.0073
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0073
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0073
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0072
790 DNA polymerase subunit alpha B POLA2 0.0071
629 Alpha-2B adrenergic receptor ADRA2B 0.0071
6220 Aryl hydrocarbon receptor AHR 0.0071
713 Sodium-dependent dopamine transporter SLC6A3 0.007
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.007
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.007
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0069
833 Organic cation/carnitine transporter 1 SLC22A4 0.0068
5691 DTDP-4-DEHYDRORHAMNOSE 3,5-EPIMERASE RMLC rmlC 0.0067
3361 Serpin B5 SERPINB5 0.0067
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0067
5694 Transcription antiterminator licT licT 0.0067
6147 Solute carrier family 22 member 3 SLC22A3 0.0067
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0066
2164 Multidrug resistance-associated protein 4 ABCC4 0.0066
1792 Tissue-type plasminogen activator PLAT 0.0066
537 ATP synthase delta chain, mitochondrial ATP5D 0.0066
378 Alpha-2C adrenergic receptor ADRA2C 0.0065
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0064
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0064
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0064
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0063
3947 Xanthine dehydrogenase/oxidase XDH 0.0063
705 Glutamate receptor 1 GRIA1 0.0063
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.0063
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0062
1757 Myeloperoxidase MPO 0.0062
6031 Cytochrome P450 3A43 CYP3A43 0.006
527 Prostacyclin receptor PTGIR 0.006
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0059
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0058
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0057
94 5-hydroxytryptamine 4 receptor HTR4 0.0057
766 Beta-2 adrenergic receptor ADRB2 0.0057
6014 Cytochrome P450 2A13 CYP2A13 0.0056
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0056
6102 Arylamine N-acetyltransferase 2 NAT2 0.0056
432 D(4) dopamine receptor DRD4 0.0056
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0054
56 Delta-aminolevulinic acid dehydratase ALAD 0.0054
2356 Delta-aminolevulinic acid dehydratase hemB 0.0054
3613 Delta-aminolevulinic acid dehydratase hemB 0.0054
3674 Delta-aminolevulinic acid dehydratase hemB 0.0054
1010 Cytochrome P450 51A1 CYP51A1 0.0052
571 Melatonin receptor type 1A MTNR1A 0.0052
362 Melatonin receptor type 1B MTNR1B 0.0052
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0051
2286 Isocitrate dehydrogenase [NADP] icd 0.0051
2302 Isocitrate dehydrogenase [NADP] icd 0.0051
2771 Isocitrate dehydrogenase [NADP] icd 0.0051
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.005
6766 O-GlcNAcase BT_4395 BT_4395 0.0049
444 Alcohol dehydrogenase 1B ADH1B 0.0049
851 5'-AMP-activated protein kinase subunit beta-2 PRKAB2 0.0049
388 AMP deaminase 1 AMPD1 0.0049
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0049
4534 Cytohesin-2 CYTH2 0.0048
251 Alcohol dehydrogenase 1A ADH1A 0.0048
3668 Maltose-binding periplasmic protein precursor malE 0.0047
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0046
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0045
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0045
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0045
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0044
6142 Solute carrier family 22 member 8 SLC22A8 0.0043
2230 Catalase CAT 0.0043
3249 Catalase katA 0.0043
3625 Catalase katA 0.0043
4539 Catalase katA 0.0043
4941 Catalase katB 0.0043
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0042
714 Glutathione reductase, mitochondrial GSR 0.0042
1291 cAMP response element-binding protein CREB1 0.0042
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0042
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0042
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0042
297 Adenylate cyclase type 1 ADCY1 0.0042
2592 Beta-galactosidase lacZ 0.0042
811 Translocator protein TSPO 0.0041
436 5-hydroxytryptamine 2B receptor HTR2B 0.0041
281 5'-AMP-activated protein kinase subunit beta-1 PRKAB1 0.004
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.004
315 Arginase-1 ARG1 0.004
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0039
6148 Multidrug resistance-associated protein 7 ABCC10 0.0039
3823 Cytokine receptor common gamma chain IL2RG 0.0039
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0039
128 Adenine phosphoribosyltransferase APRT 0.0038
605 Fumarate reductase flavoprotein subunit frdA 0.0038
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0038
3673 Fumarate reductase flavoprotein subunit fccA 0.0038
4912 Fumarate reductase flavoprotein subunit ifcA 0.0038
6549 Fumarate reductase flavoprotein subunit frdA 0.0038
4198 Fructose-1,6-bisphosphatase 1 FBP1 0.0038
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0038
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0038
24 Thymidylate synthase TMP1 0.0038
359 Thymidylate synthase TYMS 0.0038
2626 Thymidylate synthase thyA 0.0038
2729 Thymidylate synthase thyA 0.0038
5352 Thymidylate synthase THYA 0.0038
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0037
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0037
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0037
517 Alcohol dehydrogenase 1C ADH1C 0.0037
511 5-hydroxytryptamine 1F receptor HTR1F 0.0037
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0037
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0036
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0036
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0036
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0036
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0036
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0036
4604 Liver carboxylesterase 1 CES1 0.0036
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0036
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0036
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0036
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0036
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0035
869 Estrogen receptor beta ESR2 0.0035
10 Glycogen phosphorylase, liver form PYGL 0.0035
3810 Catechol O-methyltransferase COMT 0.0035
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0035
921 Glutamate receptor 2 GRIA2 0.0035
5998 Toll-like receptor 8 TLR8 0.0035
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0035
273 Apoptosis regulator Bcl-2 BCL2 0.0034
163 D(1B) dopamine receptor DRD5 0.0034
724 Interleukin-2 receptor alpha chain IL2RA 0.0034
717 Interleukin-2 receptor subunit beta IL2RB 0.0034
565 Extracellular calcium-sensing receptor CASR 0.0034
2178 Metabotropic glutamate receptor 5 GRM5 0.0034
712 Tubulin alpha chain TUB1 0.0034
153 Dopamine beta-hydroxylase DBH 0.0034
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0034
4116 Dihydropteroate synthetase Not Available 0.0033
122 P2Y purinoceptor 12 P2RY12 0.0033
904 Glutathione S-transferase P GSTP1 0.0033
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0033
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0032
518 Peroxidase/catalase T katG 0.0032
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0032
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0032
3090 Chitosanase csn 0.0031
4149 Nuclear factor NF-kappa-B p100 subunit NFKB2 0.0031
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0031
716 5-hydroxytryptamine 7 receptor HTR7 0.0031
818 50S ribosomal protein L10 rplJ 0.003
563 Thyroid peroxidase TPO 0.003
259 Microsomal triglyceride transfer protein large subunit MTTP 0.003
173 Toll-like receptor 7 TLR7 0.003
731 HIV-1 protease HIV-1 protease 0.003
1256 5-hydroxytryptamine 6 receptor HTR6 0.003
117 Sterol O-acyltransferase 1 SOAT1 0.003
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0029
373 Transthyretin TTR 0.0029
3917 Methylenetetrahydrofolate reductase MTHFR 0.0029
992 Protein tyrosine kinase 2 beta PTK2B 0.0028
1253 Interferon gamma IFNG 0.0028
330 Spermidine synthase SRM 0.0028
3038 Spermidine synthase speE 0.0028
6044 Serum paraoxonase/lactonase 3 PON3 0.0028
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0028
908 Glutathione S-transferase theta-1 GSTT1 0.0027
3404 Exotoxin A eta 0.0027
1192 Sulfotransferase 1A1 SULT1A1 0.0027
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0027
6020 Aldehyde oxidase AOX1 0.0027
3849 Insulin-like growth factor-binding protein 7 IGFBP7 0.0027
2009 Protein NOV homolog NOV 0.0027
3847 Neuroendocrine convertase 2 PCSK2 0.0027
1949 Carboxypeptidase E CPE 0.0027
3850 Synaptotagmin-like protein 4 SYTL4 0.0027
3848 Neuroendocrine convertase 1 PCSK1 0.0027
3846 Retinoblastoma-associated protein RB1 0.0027
1024 Solute carrier family 22 member 11 SLC22A11 0.0027
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0027
6432 Transporter snf 0.0026
823 Fibroblast growth factor receptor 2 FGFR2 0.0026
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0026
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.0026
284 DNA-directed RNA polymerase beta chain rpoB 0.0026
5773 DNA-directed RNA polymerase beta chain rpoB 0.0026
891 Dihydropteroate synthase folP 0.0025
5359 Dihydropteroate synthase folP 0.0025
7175 Dihydropteroate synthase sulI 0.0025
3937 Fatty-acid amide hydrolase FAAH 0.0025
5880 Thrombopoietin receptor MPL 0.0025
124 Histamine H2 receptor HRH2 0.0025
871 Glucocorticoid receptor NR3C1 0.0025
6136 Multidrug resistance-associated protein 5 ABCC5 0.0024
1517 Beta-3 adrenergic receptor ADRB3 0.0024
365 Dihydrofolate reductase DHFR 0.0024
2381 Dihydrofolate reductase DFR1 0.0024
2833 Dihydrofolate reductase Not Available 0.0024
2931 Dihydrofolate reductase folA 0.0024
3544 Dihydrofolate reductase folA 0.0024
3682 Dihydrofolate reductase folA 0.0024
6642 Dihydrofolate reductase folA 0.0024
6756 Dihydrofolate reductase dfrA 0.0024
6126 Carbonic anhydrase 7 CA7 0.0024
334 S-adenosylmethionine synthetase isoform type-2 MAT2A 0.0024
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0024
6070 Nischarin NISCH 0.0024
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0024
473 L-lactate dehydrogenase A chain LDHA 0.0024
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0024
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0023
6141 Sodium/bile acid cotransporter SLC10A1 0.0023
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0023
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0023
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0023
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0023
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.0023
847 Mu-type opioid receptor OPRM1 0.0023
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0023
358 Cystathionine beta-synthase CBS 0.0023
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0022
295 Carbonic anhydrase 1 CA1 0.0022
113 S-adenosylmethionine decarboxylase proenzyme AMD1 0.0022
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0022
275 Arachidonate 5-lipoxygenase ALOX5 0.0022
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0022
26 Vascular endothelial growth factor receptor 3 FLT4 0.0022
6146 High affinity copper uptake protein 1 SLC31A1 0.0022
411 Glycine N-methyltransferase GNMT 0.0022
2290 ADP-ribosyl cyclase 2 BST1 0.0022
2155 Insulin-degrading enzyme IDE 0.0022
65 Matrix metalloproteinase-9 Not Available 0.0021
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0021
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0021
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0021
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0021
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.0021
32 Vascular endothelial growth factor receptor 1 FLT1 0.0021
976 Platelet glycoprotein IX GP9 0.0021
400 Coagulation factor IX F9 0.0021
5461 Coagulation factor IX F9 0.0021
1374 Natriuretic peptides B NPPB 0.002
1827 Gap junction alpha-1 protein GJA1 0.002
1908 Vascular cell adhesion protein 1 VCAM1 0.002
4311 tRNA TRDMT1 0.002
4325 tRNA trmD 0.002
4328 tRNA trmD 0.002
2298 Cytochrome P450-cam camC 0.002
1820 Beta-nerve growth factor NGF 0.002
592 Carbonic anhydrase 4 CA4 0.002
4192 DNA topoisomerase 2-beta TOP2B 0.002
4228 Keratin, type II cytoskeletal 7 KRT7 0.002
228 Beta platelet-derived growth factor receptor PDGFRB 0.0019
634 Squalene monooxygenase SQLE 0.0019
7196 Squalene monooxygenase ERG1 0.0019
3932 Glutathione S-transferase A2 GSTA2 0.0019
718 Folate receptor gamma FOLR3 0.0019
299 Folate receptor beta FOLR2 0.0019
804 Mitochondrial folate transporter/carrier SLC25A32 0.0019
723 Cytosolic phospholipase A2 PLA2G4A 0.0019
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0019
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0019
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0019
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0019
6138 Multidrug resistance protein 3 ABCB4 0.0019
604 Vitamin K-dependent protein Z PROZ 0.0019
380 Cytochrome P450 17A1 CYP17A1 0.0019
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0019
512 DNA-directed RNA polymerase alpha chain rpoA 0.0019
5772 DNA-directed RNA polymerase alpha chain rpoA 0.0019
33 Cystine/glutamate transporter SLC7A11 0.0018
504 Mast/stem cell growth factor receptor KIT 0.0018
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0017
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0017
820 Glycine receptor subunit alpha-2 GLRA2 0.0017
422 Vitamin K-dependent protein C PROC 0.0017
1245 Vitamin K-dependent protein S PROS1 0.0017
1648 Elastin ELN 0.0017
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0017
6137 Multidrug resistance-associated protein 6 ABCC6 0.0017
1656 CYP2B protein CYP2B 0.0017
293 Gamma-glutamyl hydrolase GGH 0.0017
407 Vascular endothelial growth factor receptor 2 KDR 0.0017
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0017
239 Coagulation factor X F10 0.0016
696 Kappa-type opioid receptor OPRK1 0.0016
1243 Cathepsin D CTSD 0.0016
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0016
183 Vascular endothelial growth factor A VEGFA 0.0016
3601 Dihydropteroate synthase 1 folP1 0.0016
3807 Dihydropteroate synthase 1 folP1 0.0016
3808 Dihydropteroate synthase 2 folP2 0.0016
427 Substance-P receptor TACR1 0.0016
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0016
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0016
6163 Copper-transporting ATPase 2 ATP7B 0.0015
6165 Copper-transporting ATPase 1 ATP7A 0.0015
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0015
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0015
2236 Casein kinase II subunit alpha CSNK2A1 0.0015
70 Type-1 angiotensin II receptor AGTR1 0.0015
2499 Tubulin beta-2C chain TUBB2C 0.0015
3844 HLA class II histocompatibility antigen, DQ(6) alpha chain HLA-DQA2 0.0015
3913 Glutamic acid decarboxylase GAD65 0.0015
1650 Heme carrier protein 1 SLC46A1 0.0015
357 Carbonic anhydrase 2 CA2 0.0015
1275 Estrogen sulfotransferase SULT1E1 0.0015
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0014
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0014
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0014
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0014
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0014
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0014
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0014
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0014
29 Tubulin beta-1 chain TUBB1 0.0014
467 Delta-type opioid receptor OPRD1 0.0014
161 Tubulin beta chain TUBB 0.0014
312 Tubulin beta chain TUB2 0.0014
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0014
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0014
798 Osteocalcin BGLAP 0.0014
1050 Bile salt sulfotransferase SULT2A1 0.0014
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0014
2091 Endoplasmin HSP90B1 0.0014
6859 Protein S100-A4 S100A4 0.0014
1618 High affinity nerve growth factor receptor NTRK1 0.0014
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0014
2449 Tubulin alpha-3 chain TUBA1A 0.0014
1483 Membrane copper amine oxidase AOC3 0.0014
319 Opioid receptor, sigma 1 OPRS1 0.0014
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0013
751 Potassium channel subfamily K member 6 KCNK6 0.0013
1360 Sphingomyelin phosphodiesterase SMPD1 0.0013
543 Penicillin-binding protein 1B mrcB 0.0013
6186 Penicillin-binding protein 1B ponB 0.0013
6822 Penicillin-binding protein 1b pbp1b 0.0013
6844 Penicillin-binding protein 1b pbp1b 0.0013
844 Epidermal growth factor receptor EGFR 0.0013
3809 Estrogen-related receptor gamma ESRRG 0.0013
756 Sex hormone-binding globulin SHBG 0.0013
369 Coagulation factor VII F7 0.0013
645 Penicillin-binding protein 1A mrcA 0.0013
5805 Penicillin-binding protein 1A ponA 0.0013
6185 Penicillin-binding protein 1A mrcA 0.0013
6799 Penicillin-binding protein 1A pbpA 0.0013
159 Penicillin-binding protein 2B penA 0.0013
6121 Penicillin-binding protein 2B penA 0.0013
5626 Nucleoside diphosphate kinase B NME2 0.0013
528 5-hydroxytryptamine 1E receptor HTR1E 0.0013
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0013
896 Glutathione S-transferase Mu 1 GSTM1 0.0013
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0012
172 Potassium channel subfamily K member 1 KCNK1 0.0012
735 Alanine aminotransferase 1 GPT 0.0012
3904 Alanine aminotransferase 2 GPT2 0.0012
7 Nitric oxide synthase, inducible NOS2 0.0012
1629 Transcription factor AP-1 JUN 0.0012
174 Sigma 1-type opioid receptor SIGMAR1 0.0012
828 Phenylalanine-4-hydroxylase PAH 0.0011
3109 Phenylalanine-4-hydroxylase phhA 0.0011
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0011
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0011
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0011
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0011
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0011
4238 50S ribosomal protein L4 rplD 0.0011
5578 50S ribosomal protein L4 rplD 0.0011
6173 50S ribosomal protein L4 rplD 0.0011
6219 50S ribosomal protein L4 rplD 0.0011
6043 Putative G-protein coupled receptor 44 GPR44 0.0011
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0011
950 Alpha platelet-derived growth factor receptor PDGFRA 0.001
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.001
4237 50S ribosomal protein L22 rplV 0.001
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.001
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.001
1714 Mitogen-activated protein kinase 3 MAPK3 0.001
3238 Multidrug resistance protein mexA mexA 0.001
3709 Glycerol uptake facilitator protein glpF 0.001
3116 Bacterioferritin bfr 0.001
4906 Bacterioferritin bfr 0.001
4965 Bacterioferritin bfr 0.001
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.001
3173 Enolase eno 0.001
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.001
3393 TGF-beta receptor type-2 TGFBR2 0.001
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.001
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.001
564 Cellular retinoic acid-binding protein 1 CRABP1 0.001
5294 Nucleoside diphosphate kinase A NME1 0.001
6131 Carbonic anhydrase 14 CA14 0.001
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.001
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.001
859 Cellular retinoic acid-binding protein 2 CRABP2 0.001
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.001
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.001
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.001
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.001
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.001
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.001
997 Protein kinase C beta type PRKCB 0.0009
6122 Carbonic anhydrase 3 CA3 0.0009
6182 Cytochrome P450 2J2 CYP2J2 0.0009
780 Retinoic acid receptor RXR-gamma RXRG 0.0009
229 Retinoic acid receptor beta RARB 0.0009
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0009
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0009
1268 Neuropeptide S receptor NPSR1 0.0009
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0009
730 Retinoic acid receptor alpha RARA 0.0009
2852 DNA mismatch repair protein mutL mutL 0.0009
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0009
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0009
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0009
3191 Histidinol dehydrogenase hisD 0.0009
3221 Cytochrome c4 cc4 0.0009
1970 Protein kinase C alpha type PRKCA 0.0009
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0009
2408 Tyrosine-protein kinase SYK SYK 0.0009
3007 Carbonic anhydrase 12 CA12 0.0009
4205 Carbonic anhydrase 9 CA9 0.0009
740 Argininosuccinate synthase ASS1 0.0009
865 Argininosuccinate synthase ASS1 0.0009
2680 Argininosuccinate synthase argG 0.0009
3194 Argininosuccinate synthase argG 0.0009
459 Retinoic acid receptor RXR-alpha RXRA 0.0008
88 Retinoic acid receptor RXR-beta RXRB 0.0008
2981 Phospholipase A2, membrane associated PLA2G2A 0.0008
3830 Calreticulin CALR 0.0008
6459 Glycodelin PAEP 0.0008
162 Retinoic acid receptor gamma-1 RARG 0.0008
6167 Organic solute transporter subunit beta OSTB 0.0008
6073 Potassium channel subfamily K member 9 KCNK9 0.0008
6166 Organic solute transporter subunit alpha OSTA 0.0008
6072 Potassium channel subfamily K member 3 KCNK3 0.0008
4692 A/G-specific adenine glycosylase mutY 0.0008
146 Androgen receptor AR 0.0008
164 Histamine H4 receptor HRH4 0.0008
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0008
54 Prothrombin F2 0.0008
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0008
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0008
6034 Hydroxyindole O-methyltransferase ASMT 0.0008
6035 Nuclear receptor ROR-beta RORB 0.0008
6036 Eosinophil peroxidase EPX 0.0008
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0008
3856 Fibroblast growth factor receptor 3 FGFR3 0.0008
4103 Proteasome subunit beta type 2 PSMB2 0.0007
4102 Proteasome subunit beta type 5 PSMB5 0.0007
4101 Proteasome subunit beta type 1 PSMB1 0.0007
1063 Signal transducer and activator of transcription 5B STAT5B 0.0007
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0007
4226 Uridine phosphorylase 2 UPP2 0.0007
84 Nuclear receptor 0B1 NR0B1 0.0007
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0007
2802 Endoglucanase G celCCG 0.0007
822 Aldose reductase AKR1B1 0.0007
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0007
6316 ADP-ribosylation factor 1 ARF1 0.0007
291 Nitric-oxide synthase, endothelial NOS3 0.0007
6228 Nuclear receptor coactivator 1 NCOA1 0.0007
6241 Nuclear receptor coactivator 2 NCOA2 0.0007
469 Annexin A1 ANXA1 0.0007
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0007
765 Indoleamine 2,3-dioxygenase IDO1 0.0007
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0007
4225 Uridine phosphorylase 1 UPP1 0.0007
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0007
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0006
413 Amidophosphoribosyltransferase PPAT 0.0006
2515 Amidophosphoribosyltransferase purF 0.0006
3714 Amidophosphoribosyltransferase purF 0.0006
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0006
2207 Rhodopsin RHO 0.0006
936 Ephrin type-A receptor 2 EPHA2 0.0006
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0006
484 Tyrosine-protein kinase ABL2 ABL2 0.0006
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0006
1864 RET proto-oncogene RET 0.0006
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0006
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0006
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0006
3639 Thymidine phosphorylase deoA 0.0005
3936 Thymidine phosphorylase TYMP 0.0005
760 Fibroblast growth factor 1 FGF1 0.0005
5934 Cytochrome P450 26A1 CYP26A1 0.0005
1039 Histone deacetylase 9 HDAC9 0.0005
4120 NADPH--cytochrome P450 reductase POR 0.0005
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0005
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0005
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0005
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0005
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0005
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0005
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0004
6149 Solute carrier family 22 member 10 SLC22A10 0.0004
165 FL cytokine receptor FLT3 0.0004
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0004
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0004
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0004
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0004
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0004
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0004
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0004
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0004
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0004
737 Mineralocorticoid receptor NR3C2 0.0004
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0004
614 Progesterone receptor PGR 0.0003
6085 Fatty acid-binding protein, intestinal FABP2 0.0003
738 Monocarboxylate transporter 1 SLC16A1 0.0003
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0003
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0002
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