DT-Web

DB02010 - Staurosporine


Identification
Name Staurosporine
Accession Number DB02010 (EXPT02970, EXPT02972)
Type small molecule
Description An indolocarbazole that is a potent protein kinase C inhibitor which enhances cAMP-mediated responses in human neuroblastoma cells. (Biochem Biophys Res Commun 1995;214(3):1114-20)
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 466.531
Groups experimental
Monoisotopic Weight 466.200490718
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Proto-oncogene tyrosine-protein kinase LCK
Name Proto-oncogene tyrosine-protein kinase LCK
Gene Name LCK
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.5549
Proto-oncogene serine/threonine-protein kinase Pim-1
Name Proto-oncogene serine/threonine-protein kinase Pim-1
Gene Name PIM1
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.679
Tyrosine-protein kinase ITK/TSK
Name Tyrosine-protein kinase ITK/TSK
Gene Name ITK
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.5282
Tyrosine-protein kinase SYK
Name Tyrosine-protein kinase SYK
Gene Name SYK
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.7223
MAP kinase-activated protein kinase 2
Name MAP kinase-activated protein kinase 2
Gene Name MAPKAPK2
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.4885
Glycogen synthase kinase-3 beta
Name Glycogen synthase kinase-3 beta
Gene Name GSK3B
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.3043
Tyrosine-protein kinase CSK
Name Tyrosine-protein kinase CSK
Gene Name CSK
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.5483
Cell division protein kinase 2
Name Cell division protein kinase 2
Gene Name CDK2
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.8827
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
Name Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
Gene Name PIK3CG
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.5044
3-phosphoinositide-dependent protein kinase 1
Name 3-phosphoinositide-dependent protein kinase 1
Gene Name PDPK1
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.5617
Protein kinase C theta type
Name Protein kinase C theta type
Gene Name PRKCQ
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.5558
Tyrosine-protein kinase ZAP-70
Name Tyrosine-protein kinase ZAP-70
Gene Name ZAP70
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.5485

Transporters


Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions inhibitor
References
  • Budworth J, Davies R, Malkhandi J, Gant TW, Ferry DR, Gescher A: Comparison of staurosporine and four analogues: their effects on growth, rhodamine 123 retention and binding to P-glycoprotein in multidrug-resistant MCF-7/Adr cells. Br J Cancer. 1996 May;73(9):1063-8. - Pubmed
DTHybrid score 0.3421

Predictions


Id Partner name Gene Name Score
6567 MAP kinase-activated protein kinase 3 MAPKAPK3 0.2981
6235 Cyclin-A2 CCNA2 0.2743
2116 RAC-beta serine/threonine-protein kinase AKT2 0.1438
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.1322
6391 Protein kinase C iota type PRKCI 0.1198
4171 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform PIK3CD 0.117
6229 Phosphatidylinositol 3-kinase catalytic subunit type 3 PIK3C3 0.1167
476 RAC-alpha serine/threonine-protein kinase AKT1 0.1141
6392 Myotonin-protein kinase DMPK 0.1064
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.1013
4512 Cytochrome P450 3A4 CYP3A4 0.093
4750 Protein S100-A11 S100A11 0.0786
4751 Mitogen-activated protein kinase 12 MAPK12 0.0781
2207 Rhodopsin RHO 0.0775
6824 Tyrosine-protein kinase Lyn LYN 0.0726
3482 Cell division protein kinase 7 CDK7 0.0708
1742 D-HSCDK2 CDK2deltaT 0.0693
3005 Threonine-phosphate decarboxylase cobD 0.0684
1771 Cell division control protein 2 homolog CDK1 0.0673
3321 Cell division control protein 2 homolog CRK2 0.0673
6545 Calcium/calmodulin-dependent protein kinase type IV CAMK4 0.0661
1058 Cell division protein kinase 5 CDK5 0.0649
1422 Serine/threonine-protein kinase 6 AURKA 0.0618
2514 Phosphocarrier protein HPr ptsH 0.0592
5689 Phosphocarrier protein HPr ptsH 0.0592
3602 Anti-sigma F factor antagonist spoIIAA 0.0592
5686 Potassium voltage-gated channel subfamily C member 4 KCNC4 0.0592
6290 Death-associated protein kinase 3 DAPK3 0.0588
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0587
862 Multidrug resistance-associated protein 1 ABCC1 0.0586
4141 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform PIK3CA 0.0584
6264 cAMP-dependent protein kinase inhibitor alpha PKIA 0.0577
4119 Cytochrome P450 2D6 CYP2D6 0.0566
3856 Fibroblast growth factor receptor 3 FGFR3 0.0557
4924 Cytochrome P450 2C8 CYP2C8 0.0553
1130 Lithostathine 1 alpha REG1A 0.0515
4542 Glutaminase 1 glsA1 0.0515
4544 Glutaminase 1 glsA1 0.0515
1176 Mitogen-activated protein kinase 1 MAPK1 0.0512
504 Mast/stem cell growth factor receptor KIT 0.049
4318 Siroheme synthase cysG 0.0477
3119 Fimbrial protein pilE1 0.0475
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0453
3453 Alkaline phosphatase phoA 0.0448
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0439
4200 Cytochrome P450 1A2 CYP1A2 0.043
2503 Phosphomannomutase/phosphoglucomutase algC 0.0429
5150 Endo-1,4-beta-xylanase Y xynY 0.0429
6246 Serine/threonine-protein kinase PLK1 PLK1 0.0422
1281 Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 0.0421
4118 Cytochrome P450 3A5 CYP3A5 0.0413
228 Beta platelet-derived growth factor receptor PDGFRB 0.0398
407 Vascular endothelial growth factor receptor 2 KDR 0.0387
10 Glycogen phosphorylase, liver form PYGL 0.0385
26 Vascular endothelial growth factor receptor 3 FLT4 0.0384
32 Vascular endothelial growth factor receptor 1 FLT1 0.038
2950 Inositol-trisphosphate 3-kinase A ITPKA 0.035
760 Fibroblast growth factor 1 FGF1 0.0345
4757 Cytochrome P450 2C9 CYP2C9 0.0322
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0319
2379 Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide DAPP1 0.0303
2355 Tyrosine-protein kinase BTK BTK 0.0303
2348 Pleckstrin homology domain-containing family A member 4 PLEKHA4 0.0302
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0293
4534 Cytohesin-2 CYTH2 0.029
6016 Cytochrome P450 2C19 CYP2C19 0.0283
1152 Glycogen phosphorylase, muscle form PYGM 0.0281
2026 Inositol monophosphatase IMPA1 0.0272
6321 Cyclin-dependent kinase 5 activator 1 CDK5R1 0.0269
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0246
1387 Inositol monophosphatase 2 IMPA2 0.0244
6024 Cytochrome P450 1A1 CYP1A1 0.0241
6107 Cytochrome P450 3A7 CYP3A7 0.0235
587 Serum albumin ALB 0.0232
923 Glutamate receptor 3 GRIA3 0.0231
6837 Serine/threonine-protein kinase 17B STK17B 0.0206
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0206
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0203
2599 Tyrosine-protein kinase HCK HCK 0.0196
6599 HTH-type transcriptional regulator ttgR ttgR 0.0186
6030 Cytochrome P450 2B6 CYP2B6 0.0183
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.018
936 Ephrin type-A receptor 2 EPHA2 0.0173
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0172
6013 Cytochrome P450 2E1 CYP2E1 0.0171
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0169
2236 Casein kinase II subunit alpha CSNK2A1 0.0166
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.015
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.015
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.015
6832 Serine/threonine-protein kinase SRPK2 SRPK2 0.0147
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0145
997 Protein kinase C beta type PRKCB 0.0143
3390 Aminoglycoside 3'-phosphotransferase aphA 0.0137
6029 Aminoglycoside 3'-phosphotransferase aphA1 0.0137
5646 Galactokinase GALK1 0.0137
5302 TrwB trwB 0.0137
5265 FtsH ftsH 0.0137
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0134
1729 Solute carrier family 22 member 6 SLC22A6 0.0133
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.013
776 Bile salt export pump ABCB11 0.0126
5312 Kinesin-like protein KIF1A KIF1A 0.0126
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0125
6131 Carbonic anhydrase 14 CA14 0.0125
1970 Protein kinase C alpha type PRKCA 0.0124
2164 Multidrug resistance-associated protein 4 ABCC4 0.0122
6122 Carbonic anhydrase 3 CA3 0.0122
2615 Chemotaxis protein cheA cheA 0.0119
2371 Pantothenate kinase coaA 0.0119
2892 Acetylglutamate kinase argB 0.0119
3550 Acetylglutamate kinase argB 0.0119
1881 Hexokinase-1 HK1 0.0119
489 Monocarboxylate transporter 2 SLC16A7 0.0118
290 Prostaglandin G/H synthase 2 PTGS2 0.0116
2727 S-adenosylmethionine synthetase metK 0.0113
634 Squalene monooxygenase SQLE 0.0113
7196 Squalene monooxygenase ERG1 0.0113
5641 Rod shape-determining protein MreB TM_0588 0.0111
4178 DNA repair protein RAD51 homolog 1 RAD51 0.0111
5643 General secretion pathway protein E epsE 0.0111
3794 Osmolarity sensor protein envZ envZ 0.0111
5645 DNA topoisomerase 4 subunit B parE 0.0111
6227 DNA topoisomerase 4 subunit B parE 0.0111
5644 Sensor protein phoQ phoQ 0.0111
5649 Potassium-transporting ATPase B chain kdpB 0.0111
5642 Chaperone clpB clpB 0.0111
2817 Phosphoribosylglycinamide formyltransferase 2 purT 0.0109
556 Alpha-1A adrenergic receptor ADRA1A 0.0108
738 Monocarboxylate transporter 1 SLC16A1 0.0107
1898 Cytochrome P450 1B1 CYP1B1 0.0106
6145 Solute carrier family 22 member 1 SLC22A1 0.0106
4205 Carbonic anhydrase 9 CA9 0.0104
3007 Carbonic anhydrase 12 CA12 0.0104
2852 DNA mismatch repair protein mutL mutL 0.0101
871 Glucocorticoid receptor NR3C1 0.0099
6126 Carbonic anhydrase 7 CA7 0.0098
3361 Serpin B5 SERPINB5 0.0097
5694 Transcription antiterminator licT licT 0.0097
5691 DTDP-4-DEHYDRORHAMNOSE 3,5-EPIMERASE RMLC rmlC 0.0097
1024 Solute carrier family 22 member 11 SLC22A11 0.0097
2867 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase ispE 0.0097
2251 Thymidylate kinase tmk 0.0097
2254 Thymidylate kinase DTYMK 0.0097
3522 Thymidylate kinase tmk 0.0097
6433 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 PFKFB4 0.0097
2397 Dihydroxyacetone kinase dhaK 0.0097
2216 Fibroblast growth factor receptor 4 FGFR4 0.0096
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0094
193 Beta-1 adrenergic receptor ADRB1 0.0093
3822 Actin, alpha skeletal muscle ACTA1 0.0092
824 Sodium-dependent serotonin transporter SLC6A4 0.0092
5718 Cytochrome P450 2A6 CYP2A6 0.0092
540 Sodium-dependent noradrenaline transporter SLC6A2 0.009
2299 UDP-N-acetylmuramate--L-alanine ligase murC 0.0089
3231 Death-associated protein kinase 1 DAPK1 0.0089
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0089
4373 Medium-chain-fatty-acid--CoA ligase Not Available 0.0089
207 Glutathione synthetase GSS 0.0089
5269 Glutathione synthetase gshB 0.0089
831 D(2) dopamine receptor DRD2 0.0087
3923 Cholinesterase BCHE 0.0087
6144 Solute carrier family 22 member 2 SLC22A2 0.0087
1063 Signal transducer and activator of transcription 5B STAT5B 0.0086
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0086
5787 Angiopoietin-1 receptor TEK 0.0085
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0083
484 Tyrosine-protein kinase ABL2 ABL2 0.0082
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0081
492 Histamine H1 receptor HRH1 0.0081
887 DNA gyrase subunit B gyrB 0.0079
4150 DNA gyrase subunit B gyrB 0.0079
6225 DNA gyrase subunit B gyrB 0.0079
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0079
56 Delta-aminolevulinic acid dehydratase ALAD 0.0078
2356 Delta-aminolevulinic acid dehydratase hemB 0.0078
3613 Delta-aminolevulinic acid dehydratase hemB 0.0078
3674 Delta-aminolevulinic acid dehydratase hemB 0.0078
295 Carbonic anhydrase 1 CA1 0.0077
165 FL cytokine receptor FLT3 0.0077
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0075
823 Fibroblast growth factor receptor 2 FGFR2 0.0075
357 Carbonic anhydrase 2 CA2 0.0075
592 Carbonic anhydrase 4 CA4 0.0075
2286 Isocitrate dehydrogenase [NADP] icd 0.0074
2302 Isocitrate dehydrogenase [NADP] icd 0.0074
2771 Isocitrate dehydrogenase [NADP] icd 0.0074
3959 Cell division protein kinase 4 CDK4 0.0073
958 Insulin-like growth factor 1 receptor IGF1R 0.0073
4192 DNA topoisomerase 2-beta TOP2B 0.0073
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0072
136 Estrogen receptor ESR1 0.0072
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0071
766 Beta-2 adrenergic receptor ADRB2 0.007
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.007
3668 Maltose-binding periplasmic protein precursor malE 0.0068
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0067
502 5-hydroxytryptamine 2A receptor HTR2A 0.0065
844 Epidermal growth factor receptor EGFR 0.0065
817 DNA topoisomerase 2-alpha TOP2A 0.0065
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0064
24 Thymidylate synthase TMP1 0.0064
359 Thymidylate synthase TYMS 0.0064
2626 Thymidylate synthase thyA 0.0064
2729 Thymidylate synthase thyA 0.0064
5352 Thymidylate synthase THYA 0.0064
3432 Multidrug-efflux transporter 1 regulator bmrR 0.0063
244 Angiotensin-converting enzyme ACE 0.0063
4476 Mannitol dehydrogenase mtlD 0.0063
1836 Mitogen-activated protein kinase 10 MAPK10 0.0063
2592 Beta-galactosidase lacZ 0.0061
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.006
6142 Solute carrier family 22 member 8 SLC22A8 0.006
2684 Histidine triad nucleotide-binding protein 1 HINT1 0.0059
6143 Solute carrier family 22 member 7 SLC22A7 0.0059
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0059
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0059
3811 Cytochrome P450 19A1 CYP19A1 0.0058
1291 cAMP response element-binding protein CREB1 0.0058
632 Alpha-1B adrenergic receptor ADRA1B 0.0058
851 5'-AMP-activated protein kinase subunit beta-2 PRKAB2 0.0058
388 AMP deaminase 1 AMPD1 0.0058
315 Arginase-1 ARG1 0.0057
1192 Sulfotransferase 1A1 SULT1A1 0.0055
118 Organic cation/carnitine transporter 2 SLC22A5 0.0055
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0054
4198 Fructose-1,6-bisphosphatase 1 FBP1 0.0054
4604 Liver carboxylesterase 1 CES1 0.0053
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0053
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0053
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0053
297 Adenylate cyclase type 1 ADCY1 0.0053
20 Prostaglandin G/H synthase 1 PTGS1 0.0053
6182 Cytochrome P450 2J2 CYP2J2 0.0052
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0052
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0051
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0051
320 5-hydroxytryptamine 1A receptor HTR1A 0.005
789 Alpha-1D adrenergic receptor ADRA1D 0.005
6106 Cytochrome P450 2C18 CYP2C18 0.005
731 HIV-1 protease HIV-1 protease 0.005
1353 DNA topoisomerase 1 TOP1 0.005
3552 DNA topoisomerase 1 topA 0.005
128 Adenine phosphoribosyltransferase APRT 0.0049
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0049
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0049
5300 Antigen peptide transporter 1 TAP1 0.0049
6021 Adenosine kinase ADK 0.0049
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0048
23 D(1A) dopamine receptor DRD1 0.0048
281 5'-AMP-activated protein kinase subunit beta-1 PRKAB1 0.0048
847 Mu-type opioid receptor OPRM1 0.0048
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0047
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0047
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0047
2616 Ganglioside GM2 activator GM2A 0.0047
465 Calmodulin CALM1 0.0046
318 Alpha-2A adrenergic receptor ADRA2A 0.0045
5288 Shikimate kinase aroK 0.0045
5287 Signaling protein Not Available 0.0045
5304 UPF0166 protein TM_0021 TM_0021 0.0045
5314 UPF0079 ATP-binding protein HI0065 HI_0065 0.0045
5293 Shikimate kinase 2 aroL 0.0045
3199 Phosphopantetheine adenylyltransferase coaD 0.0045
3543 Phosphopantetheine adenylyltransferase coaD 0.0045
3567 Phosphopantetheine adenylyltransferase coaD 0.0045
5289 Phosphopantetheine adenylyltransferase coaD 0.0045
5259 Transcriptional regulator ntrC1 0.0045
6699 Transcriptional regulator Cgl2612 0.0045
5276 Chromosomal replication initiator protein dnaA dnaA 0.0045
5283 D-alanine--D-alanine ligase B ddlB 0.0045
2874 Nitrogenase iron protein 1 nifH1 0.0045
4346 Polynucleotide kinase pseT 0.0045
5299 D-alanine--D-alanine ligase ddl 0.0045
6598 D-alanine--D-alanine ligase ddl 0.0045
5266 Activator of hgdC 0.0045
5281 Plasmid segregation protein parM parM 0.0045
5292 Putative partitioning protein TT_C1605 0.0045
5290 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0045
5638 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0045
5270 ATP-dependent Clp protease ATP-binding subunit clpX clpX 0.0045
5291 Glycogen synthase 1 glgA1 0.0045
5305 Phosphoribosylaminoimidazole carboxylase ATPase subunit purK 0.0045
5284 Large T antigen Not Available 0.0045
4794 Phosphoenolpyruvate carboxykinase [ATP] pckA 0.0045
5275 Multidrug resistance ABC transporter ATP-binding and permease protein lmrA 0.0045
5308 Preprotein translocase secA 1 subunit secA1 0.0045
5315 Chaperone protein htpG htpG 0.0045
1549 Heat shock 70 kDa protein 1 HSPA1A 0.0045
3777 ATP-dependent Clp protease ATP-binding subunit clpA clpA 0.0045
5264 DNA replication protein REP 0.0045
5285 Kinesin heavy chain KIF5B 0.0045
5277 Preprotein translocase subunit secA secA 0.0045
3982 Phosphoribosylformylglycinamidine synthase PFAS 0.0045
5261 Phosphoribosylformylglycinamidine synthase purL 0.0045
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0045
6137 Multidrug resistance-associated protein 6 ABCC6 0.0045
124 Histamine H2 receptor HRH2 0.0044
4120 NADPH--cytochrome P450 reductase POR 0.0043
467 Delta-type opioid receptor OPRD1 0.0043
2358 cAMP-specific 3',5'-cyclic phosphodiesterase 4D PDE4D 0.0043
6141 Sodium/bile acid cotransporter SLC10A1 0.0043
260 Cytochrome P450 51 ERG11 0.0043
761 Cytochrome P450 51 ERG11 0.0043
3163 Cytochrome P450 51 cyp51 0.0043
702 UMP-CMP kinase CMPK1 0.0043
869 Estrogen receptor beta ESR2 0.0042
1714 Mitogen-activated protein kinase 3 MAPK3 0.0042
6148 Multidrug resistance-associated protein 7 ABCC10 0.0042
614 Progesterone receptor PGR 0.0041
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.004
436 5-hydroxytryptamine 2B receptor HTR2B 0.004
2317 UDP-N-acetylmuramoylalanine--D-glutamate ligase murD 0.004
6147 Solute carrier family 22 member 3 SLC22A3 0.004
696 Kappa-type opioid receptor OPRK1 0.004
474 Acetylcholinesterase ACHE 0.004
4106 Guanylate kinase GUK1 0.0039
4516 Guanylate kinase gmk 0.0039
2270 Dephospho-CoA kinase coaE 0.0039
2751 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0039
4755 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0039
2284 Adenylate kinase adk 0.0039
2296 Adenylate kinase adk 0.0039
2311 Adenylate kinase adk 0.0039
2312 Adenylate kinase Not Available 0.0039
3175 Glutamate--cysteine ligase gshA 0.0039
3470 Hypothetical protein MG245 homolog MPN_348 0.0039
5295 2-keto-3-deoxy-gluconate kinase TT_P0036 0.0039
3426 Glutamine synthetase glnA 0.0039
3987 Glutamine synthetase GLUL 0.0039
4774 NTPase P4 Not Available 0.0039
4839 DNA polymerase III subunit tau dnaX 0.0039
4837 Cag-alfa cag-alfa 0.0039
413 Amidophosphoribosyltransferase PPAT 0.0039
2515 Amidophosphoribosyltransferase purF 0.0039
3714 Amidophosphoribosyltransferase purF 0.0039
5189 Trimethylamine dehydrogenase tmd 0.0039
6277 Heat shock cognate 71 kDa protein HSPA8 0.0039
4838 PMS1 protein homolog 2 PMS2 0.0039
161 Tubulin beta chain TUBB 0.0039
312 Tubulin beta chain TUB2 0.0039
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0039
885 5-hydroxytryptamine 1B receptor HTR1B 0.0038
725 5-hydroxytryptamine 1D receptor HTR1D 0.0038
952 Dipeptidyl peptidase 4 DPP4 0.0037
340 Apoptotic protease-activating factor 1 APAF1 0.0036
122 P2Y purinoceptor 12 P2RY12 0.0036
2683 Mono-ADP-ribosyltransferase C3 C3 0.0036
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0036
2390 Nonsecretory ribonuclease RNASE2 0.0036
2922 Glycerol kinase glpK 0.0036
5271 Focal adhesion kinase 1 PTK2 0.0036
477 DNA topoisomerase 4 subunit A parC 0.0035
886 DNA topoisomerase 4 subunit A parC 0.0035
6226 DNA topoisomerase 4 subunit A parC 0.0035
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0035
2449 Tubulin alpha-3 chain TUBA1A 0.0035
404 DNA gyrase subunit A gyrA 0.0035
6224 DNA gyrase subunit A gyrA 0.0035
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0034
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0034
4366 Riboflavin kinase/FMN adenylyltransferase TM_0857 0.0034
3669 Ribokinase rbsK 0.0034
6857 [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial PDK2 0.0034
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0034
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0034
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0033
3941 Amine oxidase [flavin-containing] A MAOA 0.0033
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0033
6390 Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 ATP2A1 0.0032
408 Riboflavin kinase RFK 0.0032
3939 Amine oxidase [flavin-containing] B MAOB 0.0032
2282 Protein recA recA 0.0032
2315 Protein recA recA 0.0032
2332 Protein recA recA 0.0032
5263 Protein recA recA 0.0032
4773 Deoxycytidine kinase DCK 0.0032
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0032
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0032
833 Organic cation/carnitine transporter 1 SLC22A4 0.0031
2499 Tubulin beta-2C chain TUBB2C 0.0031
2334 Dethiobiotin synthetase bioD 0.0031
6555 Dethiobiotin synthetase bioD 0.0031
2697 Uridine-cytidine kinase 2 UCK2 0.0031
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0031
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0031
788 Creatine kinase M-type CKM 0.0031
638 D(3) dopamine receptor DRD3 0.0031
61 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.003
2644 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.003
2710 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.003
756 Sex hormone-binding globulin SHBG 0.003
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.003
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.003
590 5-hydroxytryptamine 2C receptor HTR2C 0.003
4238 50S ribosomal protein L4 rplD 0.0029
5578 50S ribosomal protein L4 rplD 0.0029
6173 50S ribosomal protein L4 rplD 0.0029
6219 50S ribosomal protein L4 rplD 0.0029
6136 Multidrug resistance-associated protein 5 ABCC5 0.0029
380 Cytochrome P450 17A1 CYP17A1 0.0029
6395 Myosin-14 MYH14 0.0029
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0029
683 Potassium transporter GK0582 0.0029
70 Type-1 angiotensin II receptor AGTR1 0.0029
5294 Nucleoside diphosphate kinase A NME1 0.0029
629 Alpha-2B adrenergic receptor ADRA2B 0.0029
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0028
2091 Endoplasmin HSP90B1 0.0028
48 Pyridoxal kinase PDXK 0.0028
3950 Cell division protein kinase 9 CDK9 0.0028
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.0028
3968 Cell division protein kinase 8 CDK8 0.0028
6138 Multidrug resistance protein 3 ABCB4 0.0028
737 Mineralocorticoid receptor NR3C2 0.0027
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0027
6232 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short GNAS 0.0027
6233 Adenylate cyclase type 2 ADCY2 0.0027
6234 Adenylate cyclase type 5 ADCY5 0.0027
3379 Kinesin-like protein KIF11 KIF11 0.0027
777 Tumor necrosis factor TNF 0.0027
4237 50S ribosomal protein L22 rplV 0.0027
3456 Heat shock protein HSP 90-beta HSP90AB1 0.0027
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0027
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0027
818 50S ribosomal protein L10 rplJ 0.0026
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0026
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0026
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0026
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0026
1852 Microtubule-associated protein 2 MAP2 0.0026
29 Tubulin beta-1 chain TUBB1 0.0025
1385 Angiotensin-converting enzyme 2 ACE2 0.0025
146 Androgen receptor AR 0.0025
185 Vasopressin V1a receptor AVPR1A 0.0024
509 Thymidine kinase TK 0.0024
570 Thymidine kinase TK 0.0024
2559 Thymidine kinase TK 0.0024
3430 Thymidine kinase tdk 0.0024
3518 Thymidine kinase TK 0.0024
5301 Thymidine kinase tdk 0.0024
5771 Thymidine kinase ORF36 0.0024
7009 Thymidine kinase ORF36 0.0024
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0024
319 Opioid receptor, sigma 1 OPRS1 0.0024
4148 Serine/threonine-protein kinase mTOR MTOR 0.0024
4341 Beta crystallin B1 CRYBB1 0.0024
4340 Hypothetical conserved protein GK2698 0.0024
6484 Hypothetical conserved protein TT_C0834 0.0024
4339 Sucrose phosphorylase sucP 0.0024
1434 Protein DJ-1 PARK7 0.0024
322 Vasopressin V2 receptor AVPR2 0.0024
4336 Glyceraldehyde 3-phosphate dehydrogenase Not Available 0.0024
4436 Glyceraldehyde 3-phosphate dehydrogenase tthHB8IM 0.0024
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0024
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0024
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0024
4103 Proteasome subunit beta type 2 PSMB2 0.0023
4102 Proteasome subunit beta type 5 PSMB5 0.0023
4101 Proteasome subunit beta type 1 PSMB1 0.0023
4221 Vascular endothelial growth factor VEGF 0.0023
5816 Cadherin-5 CDH5 0.0023
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0023
713 Sodium-dependent dopamine transporter SLC6A3 0.0023
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0023
373 Transthyretin TTR 0.0023
3955 Cell division protein kinase 6 CDK6 0.0023
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0022
5682 Ribonuclease pancreatic RNASE1 0.0022
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0022
716 5-hydroxytryptamine 7 receptor HTR7 0.0021
468 Cytochrome P450 4A11 CYP4A11 0.0021
3421 Hydroxyethylthiazole kinase thiM 0.0021
2688 Peptide deformylase def 0.0021
2708 Peptide deformylase def 0.0021
3004 Peptide deformylase def 0.0021
4337 Peptide deformylase def 0.0021
4338 Peptide deformylase def 0.0021
5368 Peptide deformylase def 0.0021
5371 Peptide deformylase def 0.0021
6375 Peptide deformylase def 0.0021
6378 Peptide deformylase def 0.0021
6379 Peptide deformylase def 0.0021
6776 Peptide deformylase def 0.0021
6900 Peptide deformylase def 0.0021
378 Alpha-2C adrenergic receptor ADRA2C 0.0021
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0021
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0021
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0021
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.002
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.002
1656 CYP2B protein CYP2B 0.002
2107 Microtubule-associated protein 1A MAP1A 0.002
3105 M-phase inducer phosphatase 2 CDC25B 0.0019
4343 Alpha-glucosidase aglA 0.0019
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0019
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0019
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0019
6085 Fatty acid-binding protein, intestinal FABP2 0.0019
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0019
239 Coagulation factor X F10 0.0019
3947 Xanthine dehydrogenase/oxidase XDH 0.0019
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0018
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0018
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0018
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0018
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0018
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0018
3168 Beta-lactamase OXA-1 bla 0.0018
4819 Hydrolase Not Available 0.0018
5249 Hydrolase Not Available 0.0018
5436 Hydrolase Not Available 0.0018
3230 Non-ATP-dependent L-selective hydantoinase lhyD 0.0018
3122 D-hydantoinase Not Available 0.0018
3145 D-hydantoinase hyuA 0.0018
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0017
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0017
594 Thyroxine-binding globulin SERPINA7 0.0017
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0017
768 FK506-binding protein 1A FKBP1A 0.0017
2840 Beta-lactamase IMP-1 Not Available 0.0017
2539 Tubulin alpha-1 chain TUBA4A 0.0016
6766 O-GlcNAcase BT_4395 BT_4395 0.0016
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0016
758 Thyroid hormone receptor alpha THRA 0.0016
511 5-hydroxytryptamine 1F receptor HTR1F 0.0015
3873 Prolyl endopeptidase PREP 0.0015
6928 Prolyl endopeptidase Not Available 0.0015
3237 Beta-lactamase OXA-2 bla 0.0015
3292 Alanine racemase, catabolic dadX 0.0015
3281 Isoaspartyl dipeptidase iadA 0.0015
4264 Alpha-L-fucosidase, putative TM_0306 0.0015
6755 Poliovirus receptor PVR 0.0015
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0015
1517 Beta-3 adrenergic receptor ADRB3 0.0015
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0015
605 Fumarate reductase flavoprotein subunit frdA 0.0015
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0015
3673 Fumarate reductase flavoprotein subunit fccA 0.0015
4912 Fumarate reductase flavoprotein subunit ifcA 0.0015
6549 Fumarate reductase flavoprotein subunit frdA 0.0015
6031 Cytochrome P450 3A43 CYP3A43 0.0015
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0015
1770 Phospholipase C PLCL1 0.0015
2841 Phospholipase C plc 0.0015
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0015
6149 Solute carrier family 22 member 10 SLC22A10 0.0015
1178 Adenosine A2a receptor ADORA2A 0.0014
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0014
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0014
904 Glutathione S-transferase P GSTP1 0.0014
2801 UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase murE 0.0014
2983 Methylmalonyl-CoA carboxyltransferase 5S subunit Not Available 0.0014
2129 Sucrase-isomaltase, intestinal SI 0.0014
346 Thyroid hormone receptor beta-1 THRB 0.0014
1629 Transcription factor AP-1 JUN 0.0014
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0014
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0014
273 Apoptosis regulator Bcl-2 BCL2 0.0013
4549 Endonuclease III HP_0602 0.0013
2646 Dihydroorotase pyrC 0.0013
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0013
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0013
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0013
6167 Organic solute transporter subunit beta OSTB 0.0013
6166 Organic solute transporter subunit alpha OSTA 0.0013
1010 Cytochrome P450 51A1 CYP51A1 0.0013
528 5-hydroxytryptamine 1E receptor HTR1E 0.0013
2717 Folylpolyglutamate synthase fgs 0.0013
6432 Transporter snf 0.0013
365 Dihydrofolate reductase DHFR 0.0013
2381 Dihydrofolate reductase DFR1 0.0013
2833 Dihydrofolate reductase Not Available 0.0013
2931 Dihydrofolate reductase folA 0.0013
3544 Dihydrofolate reductase folA 0.0013
3682 Dihydrofolate reductase folA 0.0013
6642 Dihydrofolate reductase folA 0.0013
6756 Dihydrofolate reductase dfrA 0.0013
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0012
3382 Glycolipid transfer protein GLTP 0.0012
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0012
694 Matrix protein 2 M 0.0012
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0012
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0012
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0012
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0012
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0012
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0012
2297 Genome polyprotein Not Available 0.0012
2322 Genome polyprotein Not Available 0.0012
2694 Genome polyprotein Not Available 0.0012
2719 Genome polyprotein Not Available 0.0012
2860 Genome polyprotein Not Available 0.0012
2928 Genome polyprotein Not Available 0.0012
3160 Genome polyprotein Not Available 0.0012
3260 Genome polyprotein Not Available 0.0012
4783 Genome polyprotein Not Available 0.0012
5726 Genome polyprotein Not Available 0.0012
5779 Genome polyprotein Not Available 0.0012
5867 Genome polyprotein Not Available 0.0012
6253 Genome polyprotein Not Available 0.0012
6301 Genome polyprotein Not Available 0.0012
6380 Genome polyprotein Not Available 0.0012
6381 Genome polyprotein Not Available 0.0012
6437 Genome polyprotein Not Available 0.0012
6520 Genome polyprotein Not Available 0.0012
6521 Genome polyprotein Not Available 0.0012
6652 Genome polyprotein Not Available 0.0012
6734 Genome polyprotein Not Available 0.0012
6735 Genome polyprotein Not Available 0.0012
6736 Genome polyprotein Not Available 0.0012
6737 Genome polyprotein Not Available 0.0012
6738 Genome polyprotein Not Available 0.0012
6739 Genome polyprotein Not Available 0.0012
6744 Genome polyprotein Not Available 0.0012
6748 Genome polyprotein Not Available 0.0012
6894 Genome polyprotein Not Available 0.0012
6898 Genome polyprotein Not Available 0.0012
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0012
2340 Beta-lactamase PSE-2 bla 0.0012
2796 Parathion hydrolase opd 0.0012
6539 Parathion hydrolase opd 0.0012
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0012
461 Glycine receptor subunit alpha-3 GLRA3 0.0012
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0012
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0012
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0012
6859 Protein S100-A4 S100A4 0.0012
432 D(4) dopamine receptor DRD4 0.0012
894 Alanine racemase alr 0.0012
2453 Alanine racemase alr 0.0012
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0011
707 72 kDa type IV collagenase MMP2 0.0011
2112 Toll-like receptor 9 TLR9 0.0011
469 Annexin A1 ANXA1 0.0011
5923 Microtubule-associated protein tau MAPT 0.0011
5924 Microtubule-associated protein 4 MAP4 0.0011
2300 Lysozyme E 0.0011
3633 Lysozyme R 0.0011
5597 Lysozyme 17 0.0011
6459 Glycodelin PAEP 0.0011
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0011
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0011
1618 High affinity nerve growth factor receptor NTRK1 0.0011
232 Corticosteroid-binding globulin SERPINA6 0.0011
687 Tyrosine-protein phosphatase non-receptor type 1 PTPN1 0.0011
131 Synaptic vesicular amine transporter SLC18A2 0.0011
427 Substance-P receptor TACR1 0.0011
144 Hemoglobin subunit alpha HBA1 0.001
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.001
106 Cannabinoid receptor 2 CNR2 0.001
6174 50S ribosomal protein L32 rpmF 0.001
4203 Histamine N-methyltransferase HNMT 0.001
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.001
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.001
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.001
811 Translocator protein TSPO 0.001
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.001
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.001
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.001
890 Niemann-Pick C1-like protein 1 NPC1L1 0.001
723 Cytosolic phospholipase A2 PLA2G4A 0.001
68 Cannabinoid receptor 1 CNR1 0.001
199 Monocarboxylate transporter 8 SLC16A2 0.001
65 Matrix metalloproteinase-9 Not Available 0.001
3957 Adenosine deaminase ADA 0.0009
3611 Cytidine deaminase cdd 0.0009
3707 Cytidine deaminase cdd 0.0009
4211 Cytidine deaminase CDA 0.0009
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0009
1525 Heparin-binding growth factor 2 FGF2 0.0009
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0009
3809 Estrogen-related receptor gamma ESRRG 0.0009
1569 G1/S-specific cyclin-D1 CCND1 0.0009
4210 Toll-like receptor 4 TLR4 0.0009
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0009
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0009
1760 Aminopeptidase N ANPEP 0.0009
6843 Aminopeptidase N pepN 0.0009
992 Protein tyrosine kinase 2 beta PTK2B 0.0009
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0009
6171 Solute carrier family 28 member 3 SLC28A3 0.0009
54 Prothrombin F2 0.0009
3932 Glutathione S-transferase A2 GSTA2 0.0009
1262 Corticotropin-lipotropin POMC 0.0009
117 Sterol O-acyltransferase 1 SOAT1 0.0008
3616 Fatty acid-binding protein, epidermal FABP5 0.0008
5433 UPF0230 protein TM_1468 TM_1468 0.0008
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0008
5431 Lipid binding protein Not Available 0.0008
6211 Tubulin epsilon chain TUBE1 0.0008
6212 Tubulin gamma-1 chain TUBG1 0.0008
6210 Tubulin delta chain TUBD1 0.0008
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0008
3810 Catechol O-methyltransferase COMT 0.0008
229 Retinoic acid receptor beta RARB 0.0008
780 Retinoic acid receptor RXR-gamma RXRG 0.0008
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0008
730 Retinoic acid receptor alpha RARA 0.0008
908 Glutathione S-transferase theta-1 GSTT1 0.0008
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0008
459 Retinoic acid receptor RXR-alpha RXRA 0.0007
88 Retinoic acid receptor RXR-beta RXRB 0.0007
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0007
162 Retinoic acid receptor gamma-1 RARG 0.0007
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0007
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0007
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0007
163 D(1B) dopamine receptor DRD5 0.0007
7 Nitric oxide synthase, inducible NOS2 0.0007
283 SEC14-like protein 2 SEC14L2 0.0007
6151 Monocarboxylate transporter 10 SLC16A10 0.0007
3587 Gastrotropin FABP6 0.0007
1256 5-hydroxytryptamine 6 receptor HTR6 0.0007
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0007
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0007
1630 Integrin beta-2 ITGB2 0.0007
2211 Fatty acid-binding protein, heart FABP3 0.0007
976 Platelet glycoprotein IX GP9 0.0007
1374 Natriuretic peptides B NPPB 0.0006
1827 Gap junction alpha-1 protein GJA1 0.0006
1908 Vascular cell adhesion protein 1 VCAM1 0.0006
4217 Telomerase reverse transcriptase TERT 0.0006
6228 Nuclear receptor coactivator 1 NCOA1 0.0006
814 Ryanodine receptor 1 RYR1 0.0006
6677 Myelin P2 protein PMP2 0.0006
6241 Nuclear receptor coactivator 2 NCOA2 0.0006
342 P protein [Includes: DNA-directed DNA polymerase P 0.0006
612 P protein [Includes: DNA-directed DNA polymerase P 0.0006
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0006
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0006
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0006
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0006
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0006
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0006
174 Sigma 1-type opioid receptor SIGMAR1 0.0006
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0006
6048 Troponin C, skeletal muscle TNNC2 0.0006
341 5-hydroxytryptamine 3 receptor HTR3A 0.0006
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0006
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0006
2981 Phospholipase A2, membrane associated PLA2G2A 0.0006
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0005
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0005
5626 Nucleoside diphosphate kinase B NME2 0.0005
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0005
6044 Serum paraoxonase/lactonase 3 PON3 0.0005
3238 Multidrug resistance protein mexA mexA 0.0005
3116 Bacterioferritin bfr 0.0005
4906 Bacterioferritin bfr 0.0005
4965 Bacterioferritin bfr 0.0005
3173 Enolase eno 0.0005
3709 Glycerol uptake facilitator protein glpF 0.0005
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0005
3393 TGF-beta receptor type-2 TGFBR2 0.0005
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0005
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0005
2021 Thrombomodulin THBD 0.0005
5798 Mitogen-activated protein kinase 11 MAPK11 0.0005
572 Integrin alpha-L ITGAL 0.0005
183 Vascular endothelial growth factor A VEGFA 0.0005
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0005
2183 Fatty acid-binding protein, adipocyte FABP4 0.0005
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0005
16 Adenosine A1 receptor ADORA1 0.0005
2320 Thymidine kinase, cytosolic TK1 0.0005
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0005
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0005
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0005
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0005
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0005
233 Potassium channel subfamily K member 2 KCNK2 0.0005
1864 RET proto-oncogene RET 0.0005
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0005
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0005
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0005
1275 Estrogen sulfotransferase SULT1E1 0.0005
4122 Histone deacetylase 2 HDAC2 0.0005
1050 Bile salt sulfotransferase SULT2A1 0.0005
3191 Histidinol dehydrogenase hisD 0.0005
3221 Cytochrome c4 cc4 0.0005
291 Nitric-oxide synthase, endothelial NOS3 0.0004
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0004
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0004
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0004
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0004
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0004
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0004
6102 Arylamine N-acetyltransferase 2 NAT2 0.0004
5934 Cytochrome P450 26A1 CYP26A1 0.0004
6218 Pannexin-1 PANX1 0.0004
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0004
751 Potassium channel subfamily K member 6 KCNK6 0.0004
4311 tRNA TRDMT1 0.0004
4325 tRNA trmD 0.0004
4328 tRNA trmD 0.0004
4692 A/G-specific adenine glycosylase mutY 0.0004
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0004
1360 Sphingomyelin phosphodiesterase SMPD1 0.0004
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0004
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0004
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0004
172 Potassium channel subfamily K member 1 KCNK1 0.0004
6042 Prostaglandin reductase 2 PTGR2 0.0004
6220 Aryl hydrocarbon receptor AHR 0.0004
6163 Copper-transporting ATPase 2 ATP7B 0.0004
6165 Copper-transporting ATPase 1 ATP7A 0.0004
5818 Folate receptor alpha FOLR1 0.0004
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0004
84 Nuclear receptor 0B1 NR0B1 0.0004
2802 Endoglucanase G celCCG 0.0004
2391 Ferrochelatase hemH 0.0004
6502 Ferrochelatase DKFZp686P18130 0.0004
1591 Ferrochelatase, mitochondrial FECH 0.0004
6146 High affinity copper uptake protein 1 SLC31A1 0.0004
6316 ADP-ribosylation factor 1 ARF1 0.0004
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0004
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0004
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0004
6168 Solute carrier family 22 member 16 SLC22A16 0.0004
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0004
1792 Tissue-type plasminogen activator PLAT 0.0004
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0004
6043 Putative G-protein coupled receptor 44 GPR44 0.0004
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0004
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0004
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0004
6014 Cytochrome P450 2A13 CYP2A13 0.0003
444 Alcohol dehydrogenase 1B ADH1B 0.0003
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0003
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0003
284 DNA-directed RNA polymerase beta chain rpoB 0.0003
5773 DNA-directed RNA polymerase beta chain rpoB 0.0003
293 Gamma-glutamyl hydrolase GGH 0.0003
825 Arsenical pump-driving ATPase ASNA1 0.0003
3435 Arsenical pump-driving ATPase arsA 0.0003
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0003
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0003
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0003
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0003
733 Activin receptor type 1B ACVR1B 0.0003
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0003
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0003
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0003
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0003
154 AFG3-like protein 2 AFG3L2 0.0003
395 ALK tyrosine kinase receptor Not Available 0.0003
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0003
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0003
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0003
6493 Cytochrome c oxidase subunit 6C COX6C 0.0003
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0003
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0003
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0003
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0003
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0003
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0003
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0003
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0003
6559 Cytochrome c oxidase subunit 2 ctaC 0.0003
6669 Cytochrome c oxidase subunit 2 ctaC 0.0003
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0003
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0003
6558 Cytochrome c oxidase subunit 1 ctaD 0.0003
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0003
896 Glutathione S-transferase Mu 1 GSTM1 0.0003
292 Activin receptor type-1 ACVR1 0.0003
849 Activated CDC42 kinase 1 TNK2 0.0003
33 Cystine/glutamate transporter SLC7A11 0.0003
1313 Lactoylglutathione lyase GLO1 0.0003
1650 Heme carrier protein 1 SLC46A1 0.0003
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0003
2540 Choloylglycine hydrolase cbh 0.0003
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0003
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0003
1757 Myeloperoxidase MPO 0.0003
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0003
6501 Fatty acid-binding protein, liver FABP1 0.0003
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0003
275 Arachidonate 5-lipoxygenase ALOX5 0.0003
164 Histamine H4 receptor HRH4 0.0003
76 Nitric-oxide synthase, brain NOS1 0.0002
740 Argininosuccinate synthase ASS1 0.0002
865 Argininosuccinate synthase ASS1 0.0002
2680 Argininosuccinate synthase argG 0.0002
3194 Argininosuccinate synthase argG 0.0002
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0002
3917 Methylenetetrahydrofolate reductase MTHFR 0.0002
661 ADP/ATP translocase 1 SLC25A4 0.0002
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0002
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0002
6500 Phospholipase A2 PLA2G1B 0.0002
6020 Aldehyde oxidase AOX1 0.0002
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0002
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0002
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0002
517 Alcohol dehydrogenase 1C ADH1C 0.0002
921 Glutamate receptor 2 GRIA2 0.0002
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