DT-Web

DB04265 - Beta-Sialic Acid


Identification
Name Beta-Sialic Acid
Accession Number DB04265 (EXPT02915)
Type small molecule
Description An N-acyl derivative of neuraminic acid. N-acetylneuraminic acid occurs in many polysaccharides, glycoproteins, and glycolipids in animals and bacteria. (From Dorland, 28th ed, p1518)
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 309.2699
Groups experimental
Monoisotopic Weight 309.105981211
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Sialidase
Name Sialidase
Gene Name nedA
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.8024
Endo-N-acetylneuraminidase
Name Endo-N-acetylneuraminidase
Gene Name Not Available
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.7046
Hemagglutinin-neuraminidase
Name Hemagglutinin-neuraminidase
Gene Name HN
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.7533
Tetanus toxin
Name Tetanus toxin
Gene Name tetX
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.3047

Predictions


Id Partner name Gene Name Score
2942 Sialidase nanH 0.8024
3609 Hemagglutinin-neuraminidase HN 0.7533
4335 Trans-sialidase Not Available 0.2892
5481 Trans-sialidase TCTS-154 0.2892
3547 Enterotoxin type B entB 0.1751
5482 Sialidase-2 NEU2 0.1433
4819 Hydrolase Not Available 0.101
5249 Hydrolase Not Available 0.101
5436 Hydrolase Not Available 0.101
5414 Fiber protein L5 0.0922
5418 Fiber protein L5 0.0922
1756 E-selectin SELE 0.0922
4857 Zinc-alpha-2-glycoprotein AZGP1 0.0896
3382 Glycolipid transfer protein GLTP 0.0846
5416 Coat protein VP1 Not Available 0.0846
1130 Lithostathine 1 alpha REG1A 0.0803
2324 Botulinum neurotoxin type B botB 0.078
2592 Beta-galactosidase lacZ 0.0748
2058 P-selectin SELP 0.0635
2723 Cholera enterotoxin subunit B ctxB 0.0573
4604 Liver carboxylesterase 1 CES1 0.0446
1184 Interferon beta IFNB1 0.0136
4666 Fucose-binding lectin PA-IIL lecB 0.0118
2372 Bifunctional tail protein 9 0.0118
4878 Glycoprotein hormones alpha chain CGA 0.0107
1052 Cytotoxic T-lymphocyte protein 4 CTLA4 0.0107
1072 Granzyme B GZMB 0.0107
4189 Alpha-galactosidase A GLA 0.0107
4877 Beta-mannanase man 0.0107
4871 Endo-beta-N-acetylglucosaminidase F3 endOF3 0.0107
4850 Beta-2-glycoprotein 1 APOH 0.0107
4880 Membrane cofactor protein CD46 0.0107
4856 CD209 antigen CD209 0.0107
442 Envelope glycoprotein gp41 0.0107
4859 Envelope glycoprotein env 0.0107
4889 Ig epsilon chain C region IGHE 0.0107
4852 Reticulon-4 receptor RTN4R 0.0107
757 Fusion glycoprotein F0 F 0.0107
4875 Fusion glycoprotein F0 F 0.0107
4882 Dipeptidyl aminopeptidase-like protein 6 DPP6 0.0107
4869 Major capsid protein A430L 0.0107
1563 Platelet glycoprotein Ib alpha chain GP1BA 0.0107
1354 Beta-glucuronidase GUSB 0.0107
3352 Structural polyprotein Not Available 0.0107
3628 Structural polyprotein Not Available 0.0107
4892 Structural polyprotein Not Available 0.0107
4845 ADAM 33 ADAM33 0.0107
4721 Beta-1,4-mannanase manA 0.0107
2430 Chondroitinase B cslB 0.0101
6858 Inactive carboxylesterase 4 CES1P1 0.0093
1379 Interleukin-12 subunit beta IL12B 0.0093
793 T-cell surface antigen CD2 CD2 0.0093
4861 Interleukin-6 receptor alpha chain IL6R 0.0093
119 Carcinoembryonic antigen-related cell adhesion molecule 1 CEACAM1 0.0093
4193 Atrial natriuretic peptide clearance receptor NPR3 0.0093
4890 Hemagglutinin HA 0.0093
6566 Hemagglutinin Not Available 0.0093
3837 Cytokine receptor common beta chain CSF2RB 0.0093
5577 N5-carboxyaminoimidazole ribonucleotide mutase purE 0.0088
5591 Complement component C8 gamma chain C8G 0.0088
3792 KHG/KDPG aldolase [Includes: 4-hydroxy-2-oxoglutarate aldolase eda 0.0088
5582 Regulator of transcription; stringent starvation protein A sspA 0.0088
5590 N utilization substance protein B homolog nusB 0.0088
4695 UPF0124 protein yfiH yfiH 0.0088
5588 Cell division protein FtsY TM_0570 0.0088
5587 Iron(III)-binding periplasmic protein fbpA 0.0088
2838 Ribose-5-phosphate isomerase A rpiA 0.0088
2952 Ribose-5-phosphate isomerase A rpiA 0.0088
5595 Ribose-5-phosphate isomerase A rpiA 0.0088
5598 Glycerol uptake operon antiterminator-related protein TM_1436 0.0088
5581 Beta-fructosidase bfrA 0.0088
4238 50S ribosomal protein L4 rplD 0.0088
5578 50S ribosomal protein L4 rplD 0.0088
6173 50S ribosomal protein L4 rplD 0.0088
6219 50S ribosomal protein L4 rplD 0.0088
4375 Glutamine synthetase 1 glnA1 0.0088
5592 Ribonucleoside-diphosphate reductase subunit beta nrdF 0.0088
2300 Lysozyme E 0.0088
3633 Lysozyme R 0.0088
5597 Lysozyme 17 0.0088
5583 RNA 3'-terminal phosphate cyclase rtcA 0.0088
5586 Pleckstrin homology domain-containing family A member 1 PLEKHA1 0.0088
5593 Transferase Not Available 0.0088
5060 Intron-associated endonuclease 1 ITEVIR 0.0088
5574 Invasin YPTB1668 0.0088
5575 Short tail fiber protein 12 0.0088
5600 Pyruvate decarboxylase pdc 0.0088
5580 Hexon protein PII 0.0088
3444 Cyanovirin-N Not Available 0.0086
2998 Sialic acid-binding Ig-like lectin 7 SIGLEC7 0.0086
3258 Mannosyl-oligosaccharide alpha-1,2-mannosidase MSDC 0.0086
1859 Prostatic acid phosphatase ACPP 0.0086
2297 Genome polyprotein Not Available 0.0086
2322 Genome polyprotein Not Available 0.0086
2694 Genome polyprotein Not Available 0.0086
2719 Genome polyprotein Not Available 0.0086
2860 Genome polyprotein Not Available 0.0086
2928 Genome polyprotein Not Available 0.0086
3160 Genome polyprotein Not Available 0.0086
3260 Genome polyprotein Not Available 0.0086
4783 Genome polyprotein Not Available 0.0086
5726 Genome polyprotein Not Available 0.0086
5779 Genome polyprotein Not Available 0.0086
5867 Genome polyprotein Not Available 0.0086
6253 Genome polyprotein Not Available 0.0086
6301 Genome polyprotein Not Available 0.0086
6380 Genome polyprotein Not Available 0.0086
6381 Genome polyprotein Not Available 0.0086
6437 Genome polyprotein Not Available 0.0086
6520 Genome polyprotein Not Available 0.0086
6521 Genome polyprotein Not Available 0.0086
6652 Genome polyprotein Not Available 0.0086
6734 Genome polyprotein Not Available 0.0086
6735 Genome polyprotein Not Available 0.0086
6736 Genome polyprotein Not Available 0.0086
6737 Genome polyprotein Not Available 0.0086
6738 Genome polyprotein Not Available 0.0086
6739 Genome polyprotein Not Available 0.0086
6744 Genome polyprotein Not Available 0.0086
6748 Genome polyprotein Not Available 0.0086
6894 Genome polyprotein Not Available 0.0086
6898 Genome polyprotein Not Available 0.0086
6120 Cation-independent mannose-6-phosphate receptor IGF2R 0.0086
4787 Envelope glycoprotein gp160 env 0.0081
4820 Envelope glycoprotein gp160 env 0.0081
5727 Envelope glycoprotein gp160 env 0.0081
554 Low-density lipoprotein receptor LDLR 0.0081
852 Heparin cofactor 2 SERPIND1 0.0079
18 High affinity immunoglobulin epsilon receptor subunit alpha FCER1A 0.0079
2577 Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase MAN1B1 0.0078
4533 Glyoxalase family protein BC_1747 0.0076
3132 Tryptophan synthase alpha chain trpA 0.0076
6568 Tryptophan synthase alpha chain trpA 0.0076
4992 Cytochrome c peroxidase Not Available 0.0076
3087 Nicotinate-nucleotide adenylyltransferase nadD 0.0076
4469 Nicotinate-nucleotide adenylyltransferase nadD 0.0076
3729 Citrate synthase gltA 0.0076
4575 Citrate synthase cit 0.0076
4580 Citrate synthase gltA 0.0076
5006 RNASE4 protein RNASE4 0.0076
5328 Prostaglandin F synthase Tb11.02.2310 0.0076
3085 Molybdopterin-guanine dinucleotide biosynthesis protein A mobA 0.0076
5599 3-carboxy-cis,cis-muconate cycloisomerase pcaB 0.0076
355 GMP synthase [glutamine-hydrolyzing] GMPS 0.0076
4353 GMP synthase [glutamine-hydrolyzing] guaA 0.0076
2555 Pol polyprotein pol 0.0076
3242 Pol polyprotein gag-pol 0.0076
3471 Pol polyprotein gag-pro-pol 0.0076
5256 Pol polyprotein pol 0.0076
6469 Pol polyprotein gag-pol 0.0076
6565 Pol polyprotein Not Available 0.0076
3480 Mannan endo-1,4-beta-mannosidase manA 0.0075
64 Neuraminidase NA 0.0075
641 Neuraminidase NA 0.0075
2676 Neuraminidase NA 0.0075
3026 Neuraminidase NA 0.0075
3519 Neuraminidase NA 0.0075
6007 Neuraminidase NA 0.0075
1439 Lactotransferrin LTF 0.0073
595 Fibrinogen alpha chain FGA 0.0072
1243 Cathepsin D CTSD 0.0071
2603 Beta-lactamase II blm 0.007
3583 6-phosphogluconolactonase pgl 0.007
2149 Angiogenin ANG 0.007
1467 Tumor necrosis factor ligand superfamily member 13B TNFSF13B 0.007
4373 Medium-chain-fatty-acid--CoA ligase Not Available 0.007
2521 Cell division protein ftsZ ftsZ 0.007
3301 Cell division protein ftsZ ftsZ 0.007
1782 Neutrophil gelatinase-associated lipocalin LCN2 0.007
958 Insulin-like growth factor 1 receptor IGF1R 0.0069
6307 Ig gamma-2 chain C region IGHG2 0.0068
2581 Chondroitinase AC cslA 0.0068
4366 Riboflavin kinase/FMN adenylyltransferase TM_0857 0.0067
2869 1-deoxy-D-xylulose 5-phosphate reductoisomerase dxr 0.0066
2286 Isocitrate dehydrogenase [NADP] icd 0.0066
2302 Isocitrate dehydrogenase [NADP] icd 0.0066
2771 Isocitrate dehydrogenase [NADP] icd 0.0066
3486 Fumarate hydratase class II fumC 0.0066
6847 Lactase-phlorizin hydrolase LCT 0.0066
6500 Phospholipase A2 PLA2G1B 0.0065
2805 Heparan sulfate glucosamine 3-O-sulfotransferase 3A1 HS3ST3A1 0.0064
941 Betaine--homocysteine S-methyltransferase 1 BHMT 0.0062
857 Malate dehydrogenase, mitochondrial MDH2 0.0062
332 Beta-lactamase blaZ 0.0061
2478 Beta-lactamase ampC 0.0061
2613 Beta-lactamase ampC 0.0061
2635 Beta-lactamase ampC 0.0061
2700 Beta-lactamase penP 0.0061
5445 Beta-lactamase blaB 0.0061
6019 Beta-lactamase SHV-7 0.0061
6701 Beta-lactamase cphA 0.0061
2936 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0061
5184 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0061
2697 Uridine-cytidine kinase 2 UCK2 0.0061
1123 Eosinophil cationic protein RNASE3 0.0061
2207 Rhodopsin RHO 0.0061
309 Antithrombin-III SERPINC1 0.0061
2452 Tryptophanyl-tRNA synthetase trpS 0.006
3814 Complement C1r subcomponent C1R 0.0059
5579 Carboxypeptidase B CPB1 0.0058
3384 Macrophage migration inhibitory factor MIF 0.0057
3478 Glucose-1-phosphate thymidylyltransferase rmlA 0.0056
4277 Glucose-1-phosphate thymidylyltransferase rmlA 0.0056
4785 Ig gamma-1 chain C region IGHG1 0.0056
76 Nitric-oxide synthase, brain NOS1 0.0055
411 Glycine N-methyltransferase GNMT 0.0054
128 Adenine phosphoribosyltransferase APRT 0.0049
3689 Endoglucanase A celA 0.0049
5411 Slt-IIvB stxB2e 0.0049
5563 Galectin-2 LGALS2 0.0049
3009 Beta-glucanase Not Available 0.0049
5046 Ecotin eco 0.0049
5554 D-galactose-binding periplasmic protein mglB 0.0049
3741 D-galactose-binding periplasmic protein precursor mglB 0.0049
5565 Inorganic polyphosphate/ATP-glucomannokinase ppgmk 0.0049
5568 Endoglucanase C307 celC307 0.0049
1875 Pulmonary surfactant-associated protein D SFTPD 0.0049
5562 Hexokinase Not Available 0.0049
3744 Endoglucanase SS precursor celS 0.0049
3793 Aspartate ammonia-lyase aspA 0.0049
5569 Endo-1,4-beta glucanase EngF engF 0.0049
5553 Endoglucanase E1 Acel_0614 0.0049
5559 Neopullulanase nplT 0.0049
4670 Cellulase B celB 0.0049
4668 Laminarinase TM_0024 0.0049
4671 Endoglucanase C cenC 0.0049
5570 Endoglucanase E-4 celD 0.0049
4667 BH0236 protein BH0236 0.0049
952 Dipeptidyl peptidase 4 DPP4 0.0048
20 Prostaglandin G/H synthase 1 PTGS1 0.0048
5682 Ribonuclease pancreatic RNASE1 0.0044
822 Aldose reductase AKR1B1 0.0044
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0043
1503 Galectin-7 LGALS7 0.0043
4509 Acetoin(diacetyl) reductase budC 0.0043
5176 YtnJ moxC 0.0043
5247 Endo-1,4-beta-xylanase Not Available 0.0043
5248 Endo-1,4-beta-xylanase xlnA 0.0043
5250 Endo-1,4-beta-xylanase xyl 0.0043
3525 ADP-ribose pyrophosphatase, mitochondrial NUDT9 0.0043
5498 Maltoporin lamB 0.0043
5561 Maltoporin lamB 0.0043
4622 Amylase Not Available 0.0043
2728 Glucan 1,4-alpha-maltotetraohydrolase amyP 0.0043
5056 Maltooligosyltrehalose trehalohydrolase, putative treZ 0.0043
4669 Endo-1,4-beta-xylanase A xynA 0.0043
4715 Endo-1,4-beta-xylanase A xlnA 0.0043
5560 Endo-1,4-beta-xylanase A xynA 0.0043
2705 Dimethyl sulfoxide reductase dmsA 0.0043
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0041
2856 Glucosamine-6-phosphate isomerase GNPDA1 0.0039
3747 Cellulase B precursor celB 0.0039
4811 Amylosucrase ams 0.0039
2541 Neopullulanase 1 tvaI 0.0039
3153 Quinoprotein glucose dehydrogenase-B gdhB 0.0039
3091 Maltodextrin phosphorylase malP 0.0039
2564 Glucan 1,4-alpha-maltohexaosidase Not Available 0.0039
2606 Neopullulanase 2 tvaII 0.0039
2531 Alpha-amylase amyE 0.0039
2948 Alpha-amylase amy 0.0039
3169 Alpha-amylase Not Available 0.0039
3923 Cholinesterase BCHE 0.0038
3225 Shiga toxin B-chain stxB 0.0037
4830 Aldose 1-epimerase galM 0.0037
3365 Beta-amylase spoII 0.0037
2826 Glucose--fructose oxidoreductase gfo 0.0037
1881 Hexokinase-1 HK1 0.0037
6614 Lactase-like protein LCTL 0.0035
3030 Salivary alpha-amylase AMY1A 0.0035
1675 Glucokinase GCK 0.0035
4662 Glucokinase glk 0.0035
2293 Cyclomaltodextrin glucanotransferase Not Available 0.0035
2508 Cyclomaltodextrin glucanotransferase cgt 0.0035
2523 Cyclomaltodextrin glucanotransferase cgt 0.0035
3207 Cyclomaltodextrin glucanotransferase amyA 0.0035
3668 Maltose-binding periplasmic protein precursor malE 0.0034
2448 Exoglucanase/xylanase [Includes: Exoglucanase cex 0.0034
2802 Endoglucanase G celCCG 0.0034
4692 A/G-specific adenine glycosylase mutY 0.0034
4272 POSSIBLE CELLULASE CELA1 celA1 0.0034
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0033
2440 Endoglucanase F celCCF 0.0032
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0031
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0031
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0031
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0031
2245 Xylose isomerase xylA 0.003
2253 Xylose isomerase xylA 0.003
2260 Xylose isomerase xylA 0.003
2431 Xylose isomerase xylA 0.003
2252 Endoglucanase 5A cel5A 0.003
10 Glycogen phosphorylase, liver form PYGL 0.0028
2427 Ferrichrome-iron receptor fhuA 0.0027
4513 Pancreatic alpha-amylase AMY2A 0.0027
1152 Glycogen phosphorylase, muscle form PYGM 0.0022
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