DT-Web

DB00495 - Zidovudine


Identification
Name Zidovudine
Accession Number DB00495 (APRD00449)
Type small molecule
Description A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA during reverse transcription. It improves immunologic function, partially reverses the HIV-induced neurological dysfunction, and improves certain other clinical abnormalities associated with AIDS. Its principal toxic effect is dose-dependent suppression of bone marrow, resulting in anemia and leukopenia. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 267.2413
Groups approved
Monoisotopic Weight 267.096753929
Pharmacology
Indication Used in combination with other antiretroviral agents for the treatment of human immunovirus (HIV) infections.
Mechanism of action Zidovudine, a structural analog of thymidine, is a prodrug that must be phosphorylated to its active 5?-triphosphate metabolite, zidovudine triphosphate (ZDV-TP). It inhibits the activity of HIV-1 reverse transcriptase (RT) via DNA chain termination after incorporation of the nucleotide analogue. It competes with the natural substrate dGTP and incorporates itself into viral DNA. It is also a weak inhibitor of cellular DNA polymerase ? and ?.
Absorption Rapid and nearly complete absorption from the gastrointestinal tract following oral administration; however, because of first-pass metabolism, systemic bioavailability of zidovudine capsules and solution is approximately 65% (range, 52 to 75%). Bioavailability in neonates up to 14 days of age is approximately 89%, and it decreases to approximately 61% and 65% in neonates over 14 days of age and children 3 months to 12 years, respectively. Administration with a high-fat meal may decrease the rate and extent of absorption.
Protein binding 30-38%
Biotransformation Hepatic. Metabolized by glucuronide conjugation to major, inactive metabolite, 3′-azido-3′-deoxy-5′- O-beta-D-glucopyranuronosylthymidine (GZDV). UGT2B7 is the primary UGT isoform that is responsible for glucuronidation. Compared to zidovudine, GZDV's area under the curve is approximately 3-fold greater. The cytochrome P450 isozymes are responsible for the reduction of the azido moiety to form 3'-amino-3'- deoxythymidine (AMT).
Route of elimination As in adult patients, the major route of elimination was by metabolism to GZDV. After intravenous dosing, about 29% of the dose was excreted in the urine unchanged and about 45% of the dose was excreted as GZDV.
Toxicity Symptoms of overdose include fatigue, headache, nausea, and vomiting. LD50 is 3084 mg/kg (orally in mice).
Affected organisms
  • Human Immunodeficiency Virus
Interactions
Drug Interactions
Drug Mechanism of interaction
Atovaquone Atovaquone increases the effect and toxicity of zidovudine
Clarithromycin Clarithromycin may decrease the serum concentration of zidovudine. Increased myelosuppression in mice has been observed. Consider staggering doses during concomitant therapy and closely monitor response to zidovudine therapy.
Doxorubicin Additive myelosuppression may occur. Doxorubicin may decrease the efficacy of zidovudine. Concomitant therapy should be avoided.
Ganciclovir Increased risk of hematologic toxicity. Concomitant therapy should be avoided.
Interferon beta-1b The interferon increases the effect and toxicity of zidovudine
Methadone Methadone increases the effect and toxicity of zidovudine
Probenecid Rash, malaise, myalgia
Ribavirin Increased risk or severity of anemia. Consider alternate therapy or monitor more closely for anemia.
Rifabutin The rifamycin decreases levels of zidovudine
Rifampin Rifampin may decrease the serum concentration of zidovudine by increasing its metabolism. Monitor for changes in the serum concentration and therapeutic and adverse effects of zidovudine if rifampin is initiated, discontinued or dose changed.
Rifapentine Rifapentin may decrease the serum concentration of zidovudine by increasing its metabolism. Monitor for changes in the serum concentration and therapeutic and adverse effects of zidovudine if rifapentin is initiated, discontinued or dose changed.
Stavudine Zidovudine may decrease the efficacy of stavudine. Concomitant therapy should be avoided.
Tipranavir Tipranavir decreases the concentration of Zidovudine.
Valganciclovir The adverse/toxic effects of Zidovudine, a reverse transcriptase inhibitor (nucleoside), may be enhanced by Valganciclovir. There is a significant risk of hematologic toxicity. Concomitant therapy should be avoided.
Food Interactions Not Available

Targets


Reverse transcriptase
Name Reverse transcriptase
Gene Name Not Available
Pharmacological action yes
Actions inhibitor
References
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Barry M, Gibbons S, Back D, Mulcahy F: Protease inhibitors in patients with HIV disease. Clinically important pharmacokinetic considerations. Clin Pharmacokinet. 1997 Mar;32(3):194-209. - Pubmed
  • De Clercq E: Antiretroviral drugs. Curr Opin Pharmacol. 2010 May 12. - Pubmed
DTHybrid score Not Available
Telomerase reverse transcriptase
Name Telomerase reverse transcriptase
Gene Name TERT
Pharmacological action unknown
Actions inhibitor
References
  • Leeansyah E, Cameron PU, Solomon A, Tennakoon S, Velayudham P, Gouillou M, Spelman T, Hearps A, Fairley C, Smit de V, Pierce AB, Armishaw J, Crowe SM, Cooper DA, Koelsch KK, Liu JP, Chuah J, Lewin SR: Inhibition of telomerase activity by human immunodeficiency virus (HIV) nucleos(t)ide reverse transcriptase inhibitors: a potential factor contributing to HIV-associated accelerated aging. J Infect Dis. 2013 Apr;207(7):1157-65. doi: 10.1093/infdis/jit006. Epub 2013 Jan 9. - Pubmed
DTHybrid score 0.1716

Enzymes


Cytochrome P450 2A6
Name Cytochrome P450 2A6
Gene Name CYP2A6
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3726
Cytochrome P450 2C19
Name Cytochrome P450 2C19
Gene Name CYP2C19
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
  • Takeda M, Khamdang S, Narikawa S, Kimura H, Kobayashi Y, Yamamoto T, Cha SH, Sekine T, Endou H: Human organic anion transporters and human organic cation transporters mediate renal antiviral transport. J Pharmacol Exp Ther. 2002 Mar;300(3):918-24. - Pubmed
  • Takeda M, Khamdang S, Narikawa S, Kimura H, Kobayashi Y, Yamamoto T, Cha SH, Sekine T, Endou H: Human organic anion transporters and human organic cation transporters mediate renal antiviral transport. J Pharmacol Exp Ther. 2002 Mar;300(3):918-24. - Pubmed
  • Letter: Exercise testing and coronary heart disease. N Engl J Med. 1975 Dec 4;293(23):1208-10. - Pubmed
  • Letter: Exercise testing and coronary heart disease. N Engl J Med. 1975 Dec 4;293(23):1208-10. - Pubmed
DTHybrid score 0.5555
Cytochrome P450 2C8
Name Cytochrome P450 2C8
Gene Name CYP2C8
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.5131
Cytochrome P450 2C9
Name Cytochrome P450 2C9
Gene Name CYP2C9
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.6942
Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.8084
Thymidine kinase, cytosolic
Name Thymidine kinase, cytosolic
Gene Name TK1
Actions substrate
References
  • Furman PA, Fyfe JA, St Clair MH, Weinhold K, Rideout JL, Freeman GA, Lehrman SN, Bolognesi DP, Broder S, Mitsuya H, et al.: Phosphorylation of 3'-azido-3'-deoxythymidine and selective interaction of the 5'-triphosphate with human immunodeficiency virus reverse transcriptase. Proc Natl Acad Sci U S A. 1986 Nov;83(21):8333-7. - Pubmed
DTHybrid score 0.4117
UDP-glucuronosyltransferase 2B7
Name UDP-glucuronosyltransferase 2B7
Gene Name UGT2B7
Actions substrate
References
  • Court MH, Krishnaswamy S, Hao Q, Duan SX, Patten CJ, Von Moltke LL, Greenblatt DJ: Evaluation of 3'-azido-3'-deoxythymidine, morphine, and codeine as probe substrates for UDP-glucuronosyltransferase 2B7 (UGT2B7) in human liver microsomes: specificity and influence of the UGT2B7*2 polymorphism. Drug Metab Dispos. 2003 Sep;31(9):1125-33. - Pubmed
DTHybrid score 0.2636

Transporters


Solute carrier family 22 member 2
Name Solute carrier family 22 member 2
Gene Name SLC22A2
Actions Not Available
References
  • Urakami Y, Akazawa M, Saito H, Okuda M, Inui K: cDNA cloning, functional characterization, and tissue distribution of an alternatively spliced variant of organic cation transporter hOCT2 predominantly expressed in the human kidney. J Am Soc Nephrol. 2002 Jul;13(7):1703-10. - Pubmed
DTHybrid score 0.2743
Solute carrier family 22 member 6
Name Solute carrier family 22 member 6
Gene Name SLC22A6
Actions Not Available
References
  • Wada S, Tsuda M, Sekine T, Cha SH, Kimura M, Kanai Y, Endou H: Rat multispecific organic anion transporter 1 (rOAT1) transports zidovudine, acyclovir, and other antiviral nucleoside analogs. J Pharmacol Exp Ther. 2000 Sep;294(3):844-9. - Pubmed
  • Takeda, M. et al. Human organic anion transporters and human organic cation transporters mediate renal antiviral transport. J Pharmacol Exp Ther 300, 918- 924 (2002). - Pubmed
DTHybrid score 0.656
Solute carrier family 22 member 7
Name Solute carrier family 22 member 7
Gene Name SLC22A7
Actions Not Available
References
  • Takeda M, Khamdang S, Narikawa S, Kimura H, Kobayashi Y, Yamamoto T, Cha SH, Sekine T, Endou H: Human organic anion transporters and human organic cation transporters mediate renal antiviral transport. J Pharmacol Exp Ther. 2002 Mar;300(3):918-24. - Pubmed
DTHybrid score 0.3642
Solute carrier family 22 member 8
Name Solute carrier family 22 member 8
Gene Name SLC22A8
Actions Not Available
References
  • Takeda M, Khamdang S, Narikawa S, Kimura H, Kobayashi Y, Yamamoto T, Cha SH, Sekine T, Endou H: Human organic anion transporters and human organic cation transporters mediate renal antiviral transport. J Pharmacol Exp Ther. 2002 Mar;300(3):918-24. - Pubmed
DTHybrid score 0.5294
Solute carrier family 22 member 11
Name Solute carrier family 22 member 11
Gene Name SLC22A11
Actions Not Available
References
  • Takeda M, Khamdang S, Narikawa S, Kimura H, Kobayashi Y, Yamamoto T, Cha SH, Sekine T, Endou H: Human organic anion transporters and human organic cation transporters mediate renal antiviral transport. J Pharmacol Exp Ther. 2002 Mar;300(3):918-24. - Pubmed
DTHybrid score 0.3918
Sodium/nucleoside cotransporter 1
Name Sodium/nucleoside cotransporter 1
Gene Name Not Available
Actions Not Available
References
  • Cano-Soldado P, Lorrayoz IM, Molina-Arcas M, Casado FJ, Martinez-Picado J, Lostao MP, Pastor-Anglada M: Interaction of nucleoside inhibitors of HIV-1 reverse transcriptase with the concentrative nucleoside transporter-1 (SLC28A1). Antivir Ther. 2004 Dec;9(6):993-1002. - Pubmed
DTHybrid score Not Available
Equilibrative nucleoside transporter 2
Name Equilibrative nucleoside transporter 2
Gene Name Not Available
Actions Not Available
References
  • Yao SY, Ng AM, Sundaram M, Cass CE, Baldwin SA, Young JD: Transport of antiviral 3'-deoxy-nucleoside drugs by recombinant human and rat equilibrative, nitrobenzylthioinosine (NBMPR)-insensitive (ENT2) nucleoside transporter proteins produced in Xenopus oocytes. Mol Membr Biol. 2001 Apr-Jun;18(2):161-7. - Pubmed
DTHybrid score Not Available
Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions substrate
References
  • Anderson PL, Lamba J, Aquilante CL, Schuetz E, Fletcher CV: Pharmacogenetic characteristics of indinavir, zidovudine, and lamivudine therapy in HIV-infected adults: a pilot study. J Acquir Immune Defic Syndr. 2006 Aug 1;42(4):441-9. - Pubmed
DTHybrid score 0.6245
Multidrug resistance-associated protein 4
Name Multidrug resistance-associated protein 4
Gene Name ABCC4
Actions substrate
References
  • Abla N, Chinn LW, Nakamura T, Liu L, Huang CC, Johns SJ, Kawamoto M, Stryke D, Taylor TR, Ferrin TE, Giacomini KM, Kroetz DL: The human multidrug resistance protein 4 (MRP4, ABCC4): functional analysis of a highly polymorphic gene. J Pharmacol Exp Ther. 2008 Jun;325(3):859-68. doi: 10.1124/jpet.108.136523. Epub 2008 Mar 25. - Pubmed
DTHybrid score 0.3514
Multidrug resistance-associated protein 5
Name Multidrug resistance-associated protein 5
Gene Name ABCC5
Actions substrate
References
  • Jorajuria S, Dereuddre-Bosquet N, Becher F, Martin S, Porcheray F, Garrigues A, Mabondzo A, Benech H, Grassi J, Orlowski S, Dormont D, Clayette P: ATP binding cassette multidrug transporters limit the anti-HIV activity of zidovudine and indinavir in infected human macrophages. Antivir Ther. 2004 Aug;9(4):519-28. - Pubmed
DTHybrid score 0.2452
ATP-binding cassette sub-family G member 2
Name ATP-binding cassette sub-family G member 2
Gene Name ABCG2
Actions substrate
References
  • Pan G, Giri N, Elmquist WF: Abcg2/Bcrp1 mediates the polarized transport of antiretroviral nucleosides abacavir and zidovudine. Drug Metab Dispos. 2007 Jul;35(7):1165-73. Epub 2007 Apr 16. - Pubmed
DTHybrid score 0.3596

Carriers


Solute carrier family 22 member 2
Name Solute carrier family 22 member 2
Gene Name SLC22A2
Actions
References Not Available
DTHybrid score 0.2743
Solute carrier family 22 member 6
Name Solute carrier family 22 member 6
Gene Name SLC22A6
Actions
References Not Available
DTHybrid score 0.656
Solute carrier family 22 member 7
Name Solute carrier family 22 member 7
Gene Name SLC22A7
Actions
References Not Available
DTHybrid score 0.3642
Solute carrier family 22 member 8
Name Solute carrier family 22 member 8
Gene Name SLC22A8
Actions
References Not Available
DTHybrid score 0.5294
Solute carrier family 22 member 11
Name Solute carrier family 22 member 11
Gene Name SLC22A11
Actions
References Not Available
DTHybrid score 0.3918
Sodium/nucleoside cotransporter 1
Name Sodium/nucleoside cotransporter 1
Gene Name Not Available
Actions
References Not Available
DTHybrid score Not Available
Equilibrative nucleoside transporter 2
Name Equilibrative nucleoside transporter 2
Gene Name Not Available
Actions
References Not Available
DTHybrid score Not Available
Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions
References Not Available
DTHybrid score 0.6245
Multidrug resistance-associated protein 4
Name Multidrug resistance-associated protein 4
Gene Name ABCC4
Actions
References Not Available
DTHybrid score 0.3514
Multidrug resistance-associated protein 5
Name Multidrug resistance-associated protein 5
Gene Name ABCC5
Actions
References Not Available
DTHybrid score 0.2452
ATP-binding cassette sub-family G member 2
Name ATP-binding cassette sub-family G member 2
Gene Name ABCG2
Actions
References Not Available
DTHybrid score 0.3596

Predictions


Id Partner name Gene Name Score
4119 Cytochrome P450 2D6 CYP2D6 0.3692
4200 Cytochrome P450 1A2 CYP1A2 0.3492
4118 Cytochrome P450 3A5 CYP3A5 0.2984
6030 Cytochrome P450 2B6 CYP2B6 0.2357
20 Prostaglandin G/H synthase 1 PTGS1 0.2162
6107 Cytochrome P450 3A7 CYP3A7 0.207
6013 Cytochrome P450 2E1 CYP2E1 0.2016
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.2009
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.1889
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.1759
290 Prostaglandin G/H synthase 2 PTGS2 0.1727
6145 Solute carrier family 22 member 1 SLC22A1 0.1683
862 Multidrug resistance-associated protein 1 ABCC1 0.1682
6024 Cytochrome P450 1A1 CYP1A1 0.1578
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.1394
118 Organic cation/carnitine transporter 2 SLC22A5 0.1203
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.1201
2280 Listeriolysin regulatory protein prfA 0.1195
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.1195
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.1065
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.1063
1181 Alpha-1-acid glycoprotein 1 ORM1 0.106
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.1037
3639 Thymidine phosphorylase deoA 0.1007
3936 Thymidine phosphorylase TYMP 0.1007
2333 6,7-dimethyl-8-ribityllumazine synthase ribH 0.0979
2642 6,7-dimethyl-8-ribityllumazine synthase ribH 0.0979
3216 6,7-dimethyl-8-ribityllumazine synthase ribH 0.0979
776 Bile salt export pump ABCB11 0.0963
24 Thymidylate synthase TMP1 0.0941
359 Thymidylate synthase TYMS 0.0941
2626 Thymidylate synthase thyA 0.0941
2729 Thymidylate synthase thyA 0.0941
5352 Thymidylate synthase THYA 0.0941
6106 Cytochrome P450 2C18 CYP2C18 0.0908
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0898
6147 Solute carrier family 22 member 3 SLC22A3 0.0868
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0777
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0705
6141 Sodium/bile acid cotransporter SLC10A1 0.0698
3811 Cytochrome P450 19A1 CYP19A1 0.0697
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0671
1898 Cytochrome P450 1B1 CYP1B1 0.0656
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0646
738 Monocarboxylate transporter 1 SLC16A1 0.062
833 Organic cation/carnitine transporter 1 SLC22A4 0.0609
492 Histamine H1 receptor HRH1 0.0598
6137 Multidrug resistance-associated protein 6 ABCC6 0.0581
3481 Glucose-1-phosphate thymidylyltransferase 2 rmlA2 0.0563
824 Sodium-dependent serotonin transporter SLC6A4 0.0558
6148 Multidrug resistance-associated protein 7 ABCC10 0.0557
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0545
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0541
136 Estrogen receptor ESR1 0.0527
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0511
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0488
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0485
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0485
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0485
3478 Glucose-1-phosphate thymidylyltransferase rmlA 0.0482
4277 Glucose-1-phosphate thymidylyltransferase rmlA 0.0482
3299 DNA primase/helicase 4 0.0477
4604 Liver carboxylesterase 1 CES1 0.0472
556 Alpha-1A adrenergic receptor ADRA1A 0.0471
22 30S ribosomal protein S4 rpsD 0.047
6714 30S ribosomal protein S4 rpsD 0.047
140 30S ribosomal protein S9 rpsI 0.0466
6719 30S ribosomal protein S9 rpsI 0.0466
6725 30S ribosomal protein S9 rpsI 0.0466
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0465
766 Beta-2 adrenergic receptor ADRB2 0.0455
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0449
3244 Ribonucleoside-diphosphate reductase 2 alpha subunit nrdE 0.0441
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0432
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.043
817 DNA topoisomerase 2-alpha TOP2A 0.0427
5626 Nucleoside diphosphate kinase B NME2 0.0426
3947 Xanthine dehydrogenase/oxidase XDH 0.0421
2633 Anaerobic ribonucleoside-triphosphate reductase NRDD 0.0413
891 Dihydropteroate synthase folP 0.0408
5359 Dihydropteroate synthase folP 0.0408
7175 Dihydropteroate synthase sulI 0.0408
502 5-hydroxytryptamine 2A receptor HTR2A 0.0408
6020 Aldehyde oxidase AOX1 0.0405
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0398
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0398
831 D(2) dopamine receptor DRD2 0.0396
871 Glucocorticoid receptor NR3C1 0.0392
645 Penicillin-binding protein 1A mrcA 0.0373
5805 Penicillin-binding protein 1A ponA 0.0373
6185 Penicillin-binding protein 1A mrcA 0.0373
6799 Penicillin-binding protein 1A pbpA 0.0373
2251 Thymidylate kinase tmk 0.0372
2254 Thymidylate kinase DTYMK 0.0372
3522 Thymidylate kinase tmk 0.0372
468 Cytochrome P450 4A11 CYP4A11 0.037
6149 Solute carrier family 22 member 10 SLC22A10 0.0367
847 Mu-type opioid receptor OPRM1 0.0365
6031 Cytochrome P450 3A43 CYP3A43 0.0363
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0363
633 Penicillin-binding proteins 1A/1B pbpA 0.036
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0358
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0357
6085 Fatty acid-binding protein, intestinal FABP2 0.0355
87 Hypoxanthine-guanine phosphoribosyltransferase HPRT1 0.0354
632 Alpha-1B adrenergic receptor ADRA1B 0.035
467 Delta-type opioid receptor OPRD1 0.0347
543 Penicillin-binding protein 1B mrcB 0.0347
6186 Penicillin-binding protein 1B ponB 0.0347
6822 Penicillin-binding protein 1b pbp1b 0.0347
6844 Penicillin-binding protein 1b pbp1b 0.0347
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0346
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0345
696 Kappa-type opioid receptor OPRK1 0.0343
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0342
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0341
5294 Nucleoside diphosphate kinase A NME1 0.0341
124 Histamine H2 receptor HRH2 0.0339
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0335
844 Epidermal growth factor receptor EGFR 0.0332
193 Beta-1 adrenergic receptor ADRB1 0.033
5849 cAMP-dependent protein kinase type I-alpha regulatory subunit PRKAR1A 0.0327
731 HIV-1 protease HIV-1 protease 0.0325
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0324
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0324
341 5-hydroxytryptamine 3 receptor HTR3A 0.0323
3685 Catabolite gene activator crp 0.0319
4655 Adenylate cyclase cyaC 0.0318
4759 Adenylate cyclase cyaB2 0.0318
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0313
3941 Amine oxidase [flavin-containing] A MAOA 0.0312
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0304
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0303
342 P protein [Includes: DNA-directed DNA polymerase P 0.0303
612 P protein [Includes: DNA-directed DNA polymerase P 0.0303
320 5-hydroxytryptamine 1A receptor HTR1A 0.03
338 DNA polymerase UL30 0.0297
379 DNA polymerase UL54 0.0297
697 DNA polymerase ORF28 0.0297
2482 DNA polymerase 43 0.0297
4104 DNA polymerase BALF5 0.0297
260 Cytochrome P450 51 ERG11 0.0295
761 Cytochrome P450 51 ERG11 0.0295
3163 Cytochrome P450 51 cyp51 0.0295
3923 Cholinesterase BCHE 0.0292
3917 Methylenetetrahydrofolate reductase MTHFR 0.0291
558 Solute carrier family 12 member 1 SLC12A1 0.0291
713 Sodium-dependent dopamine transporter SLC6A3 0.0291
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.029
789 Alpha-1D adrenergic receptor ADRA1D 0.029
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0286
70 Type-1 angiotensin II receptor AGTR1 0.0285
373 Transthyretin TTR 0.0282
504 Mast/stem cell growth factor receptor KIT 0.0282
1405 Thiopurine S-methyltransferase TPMT 0.0281
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.028
275 Arachidonate 5-lipoxygenase ALOX5 0.0278
23 D(1A) dopamine receptor DRD1 0.0276
756 Sex hormone-binding globulin SHBG 0.0274
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0274
6167 Organic solute transporter subunit beta OSTB 0.0272
4760 Mll3241 protein mll3241 0.0271
6166 Organic solute transporter subunit alpha OSTA 0.0271
146 Androgen receptor AR 0.0271
5353 Glutamate decarboxylase alpha gadA 0.027
404 DNA gyrase subunit A gyrA 0.0267
6224 DNA gyrase subunit A gyrA 0.0267
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0267
318 Alpha-2A adrenergic receptor ADRA2A 0.0266
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0263
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0259
4773 Deoxycytidine kinase DCK 0.0257
1 Peptidoglycan synthetase ftsI ftsI 0.0254
4155 Peptidoglycan synthetase ftsI ftsI 0.0254
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0254
887 DNA gyrase subunit B gyrB 0.0252
4150 DNA gyrase subunit B gyrB 0.0252
6225 DNA gyrase subunit B gyrB 0.0252
723 Cytosolic phospholipase A2 PLA2G4A 0.0252
6014 Cytochrome P450 2A13 CYP2A13 0.0251
590 5-hydroxytryptamine 2C receptor HTR2C 0.0249
592 Carbonic anhydrase 4 CA4 0.0249
438 Taste receptor type 1 member 2 TAS1R2 0.0248
183 Vascular endothelial growth factor A VEGFA 0.0247
6033 High affinity interleukin-8 receptor A CXCR1 0.0247
357 Carbonic anhydrase 2 CA2 0.0246
295 Carbonic anhydrase 1 CA1 0.0241
115 Penicillin-binding protein 2 mrdA 0.024
6069 Penicillin-binding protein 2 mrdA 0.024
6118 Penicillin-binding protein 2 penA 0.024
6187 Penicillin-binding protein 2 pbpA 0.024
6686 Penicillin-binding protein 2 pbp2 0.024
6939 Penicillin-binding protein 2 mrdA 0.024
7163 Penicillin-binding protein 2 pbpA 0.024
1867 Major prion protein PRNP 0.024
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.024
3939 Amine oxidase [flavin-containing] B MAOB 0.0239
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0238
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0238
122 P2Y purinoceptor 12 P2RY12 0.0234
527 Prostacyclin receptor PTGIR 0.0234
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0233
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0232
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.023
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0227
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0225
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0225
465 Calmodulin CALM1 0.0224
869 Estrogen receptor beta ESR2 0.0223
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0223
3686 Acyl-CoA thioesterase I precursor tesA 0.0222
228 Beta platelet-derived growth factor receptor PDGFRB 0.0221
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.022
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0219
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0217
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0213
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0213
6182 Cytochrome P450 2J2 CYP2J2 0.0212
6171 Solute carrier family 28 member 3 SLC28A3 0.0211
1757 Myeloperoxidase MPO 0.021
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0209
6207 30S ribosomal protein S14 rpsN 0.0207
1353 DNA topoisomerase 1 TOP1 0.0207
3552 DNA topoisomerase 1 topA 0.0207
6209 30S ribosomal protein S19 rpsS 0.0207
6712 30S ribosomal protein S19 rpsS 0.0207
6726 30S ribosomal protein S19 rpsS 0.0207
3688 Branched-chain-amino-acid aminotransferase ilvE 0.0205
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0202
26 Vascular endothelial growth factor receptor 3 FLT4 0.0201
4226 Uridine phosphorylase 2 UPP2 0.0201
407 Vascular endothelial growth factor receptor 2 KDR 0.02
6102 Arylamine N-acetyltransferase 2 NAT2 0.0199
885 5-hydroxytryptamine 1B receptor HTR1B 0.0199
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0197
2016 Dipeptidase 1 DPEP1 0.0197
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0196
889 3-oxoacyl-[acyl-carrier-protein] synthase 1 fabB 0.0196
6860 3-oxoacyl-[acyl-carrier-protein] synthase 1 kasA 0.0196
6220 Aryl hydrocarbon receptor AHR 0.0194
477 DNA topoisomerase 4 subunit A parC 0.0194
886 DNA topoisomerase 4 subunit A parC 0.0194
6226 DNA topoisomerase 4 subunit A parC 0.0194
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0194
32 Vascular endothelial growth factor receptor 1 FLT1 0.0192
1558 Transient receptor potential cation channel subfamily V member 1 TRPV1 0.0192
4120 NADPH--cytochrome P450 reductase POR 0.0191
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.019
950 Alpha platelet-derived growth factor receptor PDGFRA 0.019
952 Dipeptidyl peptidase 4 DPP4 0.0189
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0189
380 Cytochrome P450 17A1 CYP17A1 0.0188
244 Angiotensin-converting enzyme ACE 0.0187
811 Translocator protein TSPO 0.0187
614 Progesterone receptor PGR 0.0186
3957 Adenosine deaminase ADA 0.0185
6218 Pannexin-1 PANX1 0.0185
672 Prostaglandin F2-alpha receptor PTGFR 0.0183
6043 Putative G-protein coupled receptor 44 GPR44 0.0182
629 Alpha-2B adrenergic receptor ADRA2B 0.0182
273 Apoptosis regulator Bcl-2 BCL2 0.0182
29 Tubulin beta-1 chain TUBB1 0.0181
4225 Uridine phosphorylase 1 UPP1 0.0181
2981 Phospholipase A2, membrane associated PLA2G2A 0.0177
1650 Heme carrier protein 1 SLC46A1 0.0175
293 Gamma-glutamyl hydrolase GGH 0.0173
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0173
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0173
725 5-hydroxytryptamine 1D receptor HTR1D 0.0172
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0172
413 Amidophosphoribosyltransferase PPAT 0.0172
2515 Amidophosphoribosyltransferase purF 0.0172
3714 Amidophosphoribosyltransferase purF 0.0172
3233 Bile acid receptor NR1H4 0.0171
378 Alpha-2C adrenergic receptor ADRA2C 0.0171
33 Cystine/glutamate transporter SLC7A11 0.017
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0169
1389 Transforming growth factor beta-1 TGFB1 0.0169
130 Prostacyclin synthase PTGIS 0.0168
2249 Aspartate aminotransferase aspC 0.0167
2671 Aspartate aminotransferase aspC 0.0167
5490 Aspartate aminotransferase Not Available 0.0167
1198 Serum paraoxonase/arylesterase 1 PON1 0.0167
6223 Penicillin-binding protein 1C pbpC 0.0167
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0166
908 Glutathione S-transferase theta-1 GSTT1 0.0165
904 Glutathione S-transferase P GSTP1 0.0165
3810 Catechol O-methyltransferase COMT 0.0165
4237 50S ribosomal protein L22 rplV 0.0164
7 Nitric oxide synthase, inducible NOS2 0.0163
4122 Histone deacetylase 2 HDAC2 0.0163
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0161
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0161
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.016
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.016
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.016
6138 Multidrug resistance protein 3 ABCB4 0.016
3932 Glutathione S-transferase A2 GSTA2 0.016
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0159
332 Beta-lactamase blaZ 0.0159
2478 Beta-lactamase ampC 0.0159
2613 Beta-lactamase ampC 0.0159
2635 Beta-lactamase ampC 0.0159
2700 Beta-lactamase penP 0.0159
5445 Beta-lactamase blaB 0.0159
6019 Beta-lactamase SHV-7 0.0159
6701 Beta-lactamase cphA 0.0159
4238 50S ribosomal protein L4 rplD 0.0158
5578 50S ribosomal protein L4 rplD 0.0158
6173 50S ribosomal protein L4 rplD 0.0158
6219 50S ribosomal protein L4 rplD 0.0158
117 Sterol O-acyltransferase 1 SOAT1 0.0157
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0155
6126 Carbonic anhydrase 7 CA7 0.0155
65 Matrix metalloproteinase-9 Not Available 0.0154
365 Dihydrofolate reductase DHFR 0.0152
2381 Dihydrofolate reductase DFR1 0.0152
2833 Dihydrofolate reductase Not Available 0.0152
2931 Dihydrofolate reductase folA 0.0152
3544 Dihydrofolate reductase folA 0.0152
3682 Dihydrofolate reductase folA 0.0152
6642 Dihydrofolate reductase folA 0.0152
6756 Dihydrofolate reductase dfrA 0.0152
818 50S ribosomal protein L10 rplJ 0.0151
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0151
638 D(3) dopamine receptor DRD3 0.015
2261 Major NAD(P)H-flavin oxidoreductase Not Available 0.0149
2021 Thrombomodulin THBD 0.0149
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0149
161 Tubulin beta chain TUBB 0.0149
312 Tubulin beta chain TUB2 0.0149
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0148
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0148
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0148
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0147
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0147
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0146
436 5-hydroxytryptamine 2B receptor HTR2B 0.0146
482 Glycine receptor subunit alpha-1 GLRA1 0.0146
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0145
6146 High affinity copper uptake protein 1 SLC31A1 0.0145
6012 Tryptophan 2,3-dioxygenase TDO2 0.0145
588 Chromodomain-helicase-DNA-binding protein 1 CHD1 0.0144
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0144
6184 D-alanyl-D-alanine carboxypeptidase dacC dacC 0.0143
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0143
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0143
6541 Peptostreptococcal albumin-binding protein pab 0.0142
3426 Glutamine synthetase glnA 0.0141
3987 Glutamine synthetase GLUL 0.0141
867 Penicillin-binding protein 3 pbpC 0.014
6119 Penicillin-binding protein 3 pbp3 0.014
7154 Penicillin-binding protein 3 pbp3 0.014
7157 Penicillin-binding protein 3 LMHCC_2184 0.014
7162 Penicillin-binding protein 3 pbpB 0.014
7172 Penicillin-binding protein 3 pbp3 0.014
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.014
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0139
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0139
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0137
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0137
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0137
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0137
489 Monocarboxylate transporter 2 SLC16A7 0.0137
1654 Interleukin-1 beta IL1B 0.0137
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0136
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0135
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0135
3809 Estrogen-related receptor gamma ESRRG 0.0135
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0135
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0135
165 FL cytokine receptor FLT3 0.0135
474 Acetylcholinesterase ACHE 0.0134
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0133
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0133
1192 Sulfotransferase 1A1 SULT1A1 0.0133
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0133
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0132
896 Glutathione S-transferase Mu 1 GSTM1 0.0132
459 Retinoic acid receptor RXR-alpha RXRA 0.0132
3760 Penicillin-binding protein 5 precursor dacA 0.0131
705 Glutamate receptor 1 GRIA1 0.0129
1141 Sialidase-1 NEU1 0.0129
64 Neuraminidase NA 0.0129
641 Neuraminidase NA 0.0129
2676 Neuraminidase NA 0.0129
3026 Neuraminidase NA 0.0129
3519 Neuraminidase NA 0.0129
6007 Neuraminidase NA 0.0129
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0128
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0128
1178 Adenosine A2a receptor ADORA2A 0.0128
537 ATP synthase delta chain, mitochondrial ATP5D 0.0127
53 Solute carrier family 12 member 5 SLC12A5 0.0127
663 Solute carrier family 12 member 4 SLC12A4 0.0127
819 Penicillin-binding protein 4 dacB 0.0125
2183 Fatty acid-binding protein, adipocyte FABP4 0.0124
6042 Prostaglandin reductase 2 PTGR2 0.0124
6163 Copper-transporting ATPase 2 ATP7B 0.0123
6165 Copper-transporting ATPase 1 ATP7A 0.0123
232 Corticosteroid-binding globulin SERPINA6 0.0123
4203 Histamine N-methyltransferase HNMT 0.0123
68 Cannabinoid receptor 1 CNR1 0.0123
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0123
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0123
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0122
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0122
308 30S ribosomal protein S12 rpsL 0.0122
6704 30S ribosomal protein S12 rpsL 0.0122
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0122
1313 Lactoylglutathione lyase GLO1 0.0122
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0122
16 Adenosine A1 receptor ADORA1 0.012
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.012
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.012
4094 Gamma-aminobutyric acid type B receptor, subunit 2 GABBR2 0.0119
310 Solute carrier family 12 member 2 SLC12A2 0.0119
1648 Elastin ELN 0.0118
2539 Tubulin alpha-1 chain TUBA4A 0.0118
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0118
2211 Fatty acid-binding protein, heart FABP3 0.0114
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0114
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0114
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0113
1507 Cytochrome c CYCS 0.0113
494 Caspase-1 CASP1 0.0111
1852 Microtubule-associated protein 2 MAP2 0.0111
4790 Glycosyltransferase GtfA gtfA 0.011
777 Tumor necrosis factor TNF 0.0109
284 DNA-directed RNA polymerase beta chain rpoB 0.0109
5773 DNA-directed RNA polymerase beta chain rpoB 0.0109
5787 Angiopoietin-1 receptor TEK 0.0108
737 Mineralocorticoid receptor NR3C2 0.0108
432 D(4) dopamine receptor DRD4 0.0107
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0107
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0107
54 Prothrombin F2 0.0106
6599 HTH-type transcriptional regulator ttgR ttgR 0.0105
1039 Histone deacetylase 9 HDAC9 0.0105
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0104
594 Thyroxine-binding globulin SERPINA7 0.0104
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0103
1792 Tissue-type plasminogen activator PLAT 0.0103
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0103
5818 Folate receptor alpha FOLR1 0.0102
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0102
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0102
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0102
716 5-hydroxytryptamine 7 receptor HTR7 0.0102
5482 Sialidase-2 NEU2 0.0101
1618 High affinity nerve growth factor receptor NTRK1 0.0101
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0101
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0099
106 Cannabinoid receptor 2 CNR2 0.0099
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0098
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0098
603 DNA polymerase alpha catalytic subunit POLA1 0.0098
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0097
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0097
4116 Dihydropteroate synthetase Not Available 0.0097
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0097
718 Folate receptor gamma FOLR3 0.0097
299 Folate receptor beta FOLR2 0.0097
804 Mitochondrial folate transporter/carrier SLC25A32 0.0097
758 Thyroid hormone receptor alpha THRA 0.0096
49 Endothelin B receptor EDNRB 0.0096
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0095
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0095
566 Serotransferrin TF 0.0094
240 Gamma-aminobutyric acid type B receptor, subunit 1 GABBR1 0.0093
3587 Gastrotropin FABP6 0.0093
2077 Caspase-3 CASP3 0.0093
5923 Microtubule-associated protein tau MAPT 0.0093
5924 Microtubule-associated protein 4 MAP4 0.0093
992 Protein tyrosine kinase 2 beta PTK2B 0.0092
1010 Cytochrome P450 51A1 CYP51A1 0.0092
1050 Bile salt sulfotransferase SULT2A1 0.0092
1760 Aminopeptidase N ANPEP 0.0092
6843 Aminopeptidase N pepN 0.0092
2461 D-alanyl-D-alanine carboxypeptidase Not Available 0.0092
5756 D-alanyl-D-alanine carboxypeptidase dac 0.0092
88 Retinoic acid receptor RXR-beta RXRB 0.0091
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0091
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0091
578 Endothelin-1 receptor EDNRA 0.009
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.009
702 UMP-CMP kinase CMPK1 0.0089
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0088
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0088
1656 CYP2B protein CYP2B 0.0088
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0088
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0087
921 Glutamate receptor 2 GRIA2 0.0087
571 Melatonin receptor type 1A MTNR1A 0.0087
362 Melatonin receptor type 1B MTNR1B 0.0087
1517 Beta-3 adrenergic receptor ADRB3 0.0087
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0087
6010 Thiamine transporter 1 SLC19A2 0.0086
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0086
131 Synaptic vesicular amine transporter SLC18A2 0.0086
6174 50S ribosomal protein L32 rpmF 0.0086
346 Thyroid hormone receptor beta-1 THRB 0.0085
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0085
427 Substance-P receptor TACR1 0.0084
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0083
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0083
528 5-hydroxytryptamine 1E receptor HTR1E 0.0083
4148 Serine/threonine-protein kinase mTOR MTOR 0.0083
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0083
469 Annexin A1 ANXA1 0.0082
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0082
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0081
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0081
518 Peroxidase/catalase T katG 0.008
6432 Transporter snf 0.008
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.008
2472 Voltage-gated potassium channel kcsA 0.008
6366 Voltage-gated potassium channel kcsA 0.008
94 5-hydroxytryptamine 4 receptor HTR4 0.008
277 Purine nucleoside phosphorylase PNP 0.008
2870 Purine nucleoside phosphorylase punA 0.008
2945 Purine nucleoside phosphorylase punA 0.008
4659 Purine nucleoside phosphorylase TM_1596 0.008
4825 Purine nucleoside phosphorylase TTHA1435 0.008
6525 Group IID secretory phospholipase A2 PLA2G2D 0.008
1119 Peroxiredoxin-5, mitochondrial PRDX5 0.0079
239 Coagulation factor X F10 0.0079
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0079
1770 Phospholipase C PLCL1 0.0079
2841 Phospholipase C plc 0.0079
1629 Transcription factor AP-1 JUN 0.0078
2449 Tubulin alpha-3 chain TUBA1A 0.0078
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0078
442 Envelope glycoprotein gp41 0.0078
4859 Envelope glycoprotein env 0.0078
1630 Integrin beta-2 ITGB2 0.0077
511 5-hydroxytryptamine 1F receptor HTR1F 0.0077
175 Thiamin pyrophosphokinase 1 TPK1 0.0077
780 Retinoic acid receptor RXR-gamma RXRG 0.0076
517 Alcohol dehydrogenase 1C ADH1C 0.0076
823 Fibroblast growth factor receptor 2 FGFR2 0.0076
163 D(1B) dopamine receptor DRD5 0.0075
6131 Carbonic anhydrase 14 CA14 0.0075
281 5'-AMP-activated protein kinase subunit beta-1 PRKAB1 0.0074
1541 Metalloproteinase mmp20 0.0074
1275 Estrogen sulfotransferase SULT1E1 0.0074
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0074
634 Squalene monooxygenase SQLE 0.0073
7196 Squalene monooxygenase ERG1 0.0073
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0073
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0073
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0072
84 Nuclear receptor 0B1 NR0B1 0.0072
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0072
3856 Fibroblast growth factor receptor 3 FGFR3 0.0071
2230 Catalase CAT 0.0071
3249 Catalase katA 0.0071
3625 Catalase katA 0.0071
4539 Catalase katA 0.0071
4941 Catalase katB 0.0071
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0071
5300 Antigen peptide transporter 1 TAP1 0.0071
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.007
6122 Carbonic anhydrase 3 CA3 0.007
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.007
2853 14 kDa fatty acid-binding protein Not Available 0.0068
164 Histamine H4 receptor HRH4 0.0067
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0067
4192 DNA topoisomerase 2-beta TOP2B 0.0066
36 Insulin receptor INSR 0.0066
162 Retinoic acid receptor gamma-1 RARG 0.0066
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0066
1196 Complement decay-accelerating factor CD55 0.0065
3611 Cytidine deaminase cdd 0.0065
3707 Cytidine deaminase cdd 0.0065
4211 Cytidine deaminase CDA 0.0065
3432 Multidrug-efflux transporter 1 regulator bmrR 0.0063
4476 Mannitol dehydrogenase mtlD 0.0063
6044 Serum paraoxonase/lactonase 3 PON3 0.0063
133 Dihydropterate synthase sulI 0.0063
5126 Arginase rocF 0.0062
251 Alcohol dehydrogenase 1A ADH1A 0.0062
768 FK506-binding protein 1A FKBP1A 0.0062
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0061
976 Platelet glycoprotein IX GP9 0.0061
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.006
176 30S ribosomal protein S10 rpsJ 0.006
6175 30S ribosomal protein S10 rpsJ 0.006
3007 Carbonic anhydrase 12 CA12 0.006
4205 Carbonic anhydrase 9 CA9 0.006
509 Thymidine kinase TK 0.006
570 Thymidine kinase TK 0.006
2559 Thymidine kinase TK 0.006
3430 Thymidine kinase tdk 0.006
3518 Thymidine kinase TK 0.006
5301 Thymidine kinase tdk 0.006
5771 Thymidine kinase ORF36 0.006
7009 Thymidine kinase ORF36 0.006
4117 Probable pyruvate-flavodoxin oxidoreductase ydbK 0.006
2300 Lysozyme E 0.006
3633 Lysozyme R 0.006
5597 Lysozyme 17 0.006
199 Monocarboxylate transporter 8 SLC16A2 0.006
185 Vasopressin V1a receptor AVPR1A 0.006
6103 Arylamine N-acetyltransferase 1 NAT1 0.0059
1864 RET proto-oncogene RET 0.0059
694 Matrix protein 2 M 0.0059
444 Alcohol dehydrogenase 1B ADH1B 0.0059
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0059
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0059
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0059
572 Integrin alpha-L ITGAL 0.0059
3382 Glycolipid transfer protein GLTP 0.0058
322 Vasopressin V2 receptor AVPR2 0.0058
6501 Fatty acid-binding protein, liver FABP1 0.0058
471 Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) SLC6A14 0.0057
707 72 kDa type IV collagenase MMP2 0.0057
563 Thyroid peroxidase TPO 0.0057
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0057
2808 Chloramphenicol acetyltransferase 3 cat3 0.0057
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0057
685 Oxygen-insensitive NADPH nitroreductase nfsA 0.0057
6945 Oxygen-insensitive NADPH nitroreductase rdxA 0.0057
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0056
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0056
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0055
856 Vitamin D3 receptor VDR 0.0055
936 Ephrin type-A receptor 2 EPHA2 0.0055
5934 Cytochrome P450 26A1 CYP26A1 0.0055
319 Opioid receptor, sigma 1 OPRS1 0.0055
814 Ryanodine receptor 1 RYR1 0.0055
466 Solute carrier family 12 member 3 SLC12A3 0.0055
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0054
4252 Penicillin-binding protein 5 dacA 0.0053
6111 DNA polymerase epsilon subunit 4 POLE4 0.0053
6112 DNA polymerase epsilon subunit 3 POLE3 0.0053
6108 Ribonucleoside-diphosphate reductase subunit M2 B RRM2B 0.0053
6110 DNA polymerase epsilon subunit 2 POLE2 0.0053
6109 DNA polymerase epsilon catalytic subunit A POLE 0.0053
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0053
4103 Proteasome subunit beta type 2 PSMB2 0.0052
4102 Proteasome subunit beta type 5 PSMB5 0.0052
4101 Proteasome subunit beta type 1 PSMB1 0.0052
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0052
159 Penicillin-binding protein 2B penA 0.0052
6121 Penicillin-binding protein 2B penA 0.0052
2417 Chloramphenicol acetyltransferase cat 0.0052
3278 Chloramphenicol acetyltransferase cat 0.0052
267 Plasminogen activator inhibitor 1 SERPINE1 0.0052
2810 Dr hemagglutinin structural subunit draA 0.0052
153 Dopamine beta-hydroxylase DBH 0.0052
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0051
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0051
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0051
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0051
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0051
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0051
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0051
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0051
253 Sodium/potassium-transporting ATPase gamma chain FXYD2 0.0051
461 Glycine receptor subunit alpha-3 GLRA3 0.0051
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0051
1992 Vitamin D-binding protein GC 0.0051
2391 Ferrochelatase hemH 0.0051
6502 Ferrochelatase DKFZp686P18130 0.0051
1591 Ferrochelatase, mitochondrial FECH 0.0051
2616 Ganglioside GM2 activator GM2A 0.0051
2499 Tubulin beta-2C chain TUBB2C 0.0051
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.005
1256 5-hydroxytryptamine 6 receptor HTR6 0.005
624 Guanidinoacetate N-methyltransferase GAMT 0.005
6027 Alkaline phosphatase, tissue-nonspecific isozyme ALPL 0.005
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0049
1714 Mitogen-activated protein kinase 3 MAPK3 0.0049
229 Retinoic acid receptor beta RARB 0.0049
1830 5'-nucleotidase NT5E 0.0049
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0048
4210 Toll-like receptor 4 TLR4 0.0048
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0048
6070 Nischarin NISCH 0.0048
730 Retinoic acid receptor alpha RARA 0.0048
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0047
6677 Myelin P2 protein PMP2 0.0047
6221 Steroid hormone receptor ERR1 ESRRA 0.0047
1341 Histamine H3 receptor HRH3 0.0047
4218 Ribonucleoside-diphosphate reductase M2 subunit RRM2 0.0047
268 Adenosine A2b receptor ADORA2B 0.0047
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0047
125 DNA polymerase beta POLB 0.0047
683 Potassium transporter GK0582 0.0047
751 Potassium channel subfamily K member 6 KCNK6 0.0046
6824 Tyrosine-protein kinase Lyn LYN 0.0046
6151 Monocarboxylate transporter 10 SLC16A10 0.0046
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0046
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0046
828 Phenylalanine-4-hydroxylase PAH 0.0046
3109 Phenylalanine-4-hydroxylase phhA 0.0046
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0046
1291 cAMP response element-binding protein CREB1 0.0045
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0045
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0045
208 DNA-directed RNA polymerase beta' chain rpoC 0.0044
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0044
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0044
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0044
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0044
6339 Ig kappa chain V-II region RPMI 6410 Not Available 0.0044
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0044
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0044
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0044
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0044
6493 Cytochrome c oxidase subunit 6C COX6C 0.0044
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0044
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0044
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0044
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0044
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0044
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0044
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0044
6559 Cytochrome c oxidase subunit 2 ctaC 0.0044
6669 Cytochrome c oxidase subunit 2 ctaC 0.0044
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0044
6558 Cytochrome c oxidase subunit 1 ctaD 0.0044
6211 Tubulin epsilon chain TUBE1 0.0044
6212 Tubulin gamma-1 chain TUBG1 0.0044
6210 Tubulin delta chain TUBD1 0.0044
4041 Microsomal glutathione S-transferase 2 MGST2 0.0044
2599 Tyrosine-protein kinase HCK HCK 0.0044
2178 Metabotropic glutamate receptor 5 GRM5 0.0044
5645 DNA topoisomerase 4 subunit B parE 0.0044
6227 DNA topoisomerase 4 subunit B parE 0.0044
581 Cytochrome P450 2R1 CYP2R1 0.0043
1483 Membrane copper amine oxidase AOC3 0.0043
2207 Rhodopsin RHO 0.0043
172 Potassium channel subfamily K member 1 KCNK1 0.0043
5698 Riboflavin synthase alpha chain ribE 0.0043
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0042
3937 Fatty-acid amide hydrolase FAAH 0.0042
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0041
408 Riboflavin kinase RFK 0.0041
2298 Cytochrome P450-cam camC 0.0041
5798 Mitogen-activated protein kinase 11 MAPK11 0.0041
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
2540 Choloylglycine hydrolase cbh 0.004
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.004
6508 Putative uncharacterized protein srtB 0.004
6543 Putative uncharacterized protein tcp14 0.004
6615 Putative uncharacterized protein MT0785 0.004
6623 Putative uncharacterized protein Not Available 0.004
6806 Putative uncharacterized protein AGR_C_2535 0.004
6813 Putative uncharacterized protein SAV4671 0.004
6815 Putative uncharacterized protein AFE_1514 0.004
6819 Putative uncharacterized protein RUMGNA_03254 0.004
6825 Putative uncharacterized protein CV_3270 0.004
4311 tRNA TRDMT1 0.004
4325 tRNA trmD 0.004
4328 tRNA trmD 0.004
4161 Furin FURIN 0.004
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.004
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.004
4034 Glutaredoxin-1 GLRX 0.004
4043 Glutaredoxin-2, mitochondrial GLRX2 0.004
4037 Hypothetical protein GPX1 0.004
4297 Hypothetical protein SP_1951 0.004
4521 Hypothetical protein BC_2969 0.004
4540 Hypothetical protein TM_1070 0.004
4555 Hypothetical protein MT1739 0.004
4569 Hypothetical protein mshD 0.004
4578 Hypothetical protein PA3270 0.004
4747 Hypothetical protein PA3967 0.004
5177 Hypothetical protein TM_0096 0.004
5194 Hypothetical protein PA1204 0.004
5240 Hypothetical protein Rv2991 0.004
5370 Hypothetical protein TM_1158 0.004
5710 Hypothetical protein Tb927.5.1360 0.004
1928 Leukotriene C4 synthase LTC4S 0.004
4029 Microsomal glutathione S-transferase 3 MGST3 0.004
4032 Microsomal glutathione S-transferase 1 MGST1 0.004
4030 Thioredoxin domain-containing protein 12 TXNDC12 0.004
4035 Glutathione S-transferase Mu 5 GSTM5 0.004
4039 CDNA FLJ23636 fis, clone CAS07176 GPX8 0.004
4040 Glutathione peroxidase 7 GPX7 0.004
910 Epididymal secretory glutathione peroxidase GPX5 0.004
4036 Glutathione peroxidase 6 GPX6 0.004
903 Glutathione S-transferase A5 GSTA5 0.004
911 Glutathione peroxidase 3 GPX3 0.004
906 Glutathione peroxidase 1 GPX1 0.004
900 Glutathione S-transferase A4 GSTA4 0.004
4038 Glutathione peroxidase 4 GPX4 0.004
1975 Phospholipid hydroperoxide glutathione peroxidase, mitochondrial GPX4 0.004
4042 Glutathione transferase omega-2 GSTO2 0.004
907 Glutathione peroxidase 2 GPX2 0.004
4033 S-formylglutathione hydrolase ESD 0.004
1056 Gamma-glutamyltranspeptidase 1 GGT1 0.004
1360 Sphingomyelin phosphodiesterase SMPD1 0.004
2408 Tyrosine-protein kinase SYK SYK 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
6067 Penicillin binding protein 2a mecA 0.0038
3830 Calreticulin CALR 0.0038
4164 Potassium voltage-gated channel subfamily KQT member 5 KCNQ5 0.0038
4163 Potassium voltage-gated channel subfamily KQT member 4 KCNQ4 0.0038
85 Growth hormone receptor GHR 0.0038
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0037
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0037
6168 Solute carrier family 22 member 16 SLC22A16 0.0037
1525 Heparin-binding growth factor 2 FGF2 0.0037
2216 Fibroblast growth factor receptor 4 FGFR4 0.0037
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0037
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0036
3616 Fatty acid-binding protein, epidermal FABP5 0.0036
5431 Lipid binding protein Not Available 0.0036
5433 UPF0230 protein TM_1468 TM_1468 0.0036
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0036
749 Amiloride-sensitive cation channel 1, neuronal ACCN1 0.0036
1636 Trace amine-associated receptor 1 TAAR1 0.0036
3319 Hydroxyacylglutathione hydrolase HAGH 0.0036
5682 Ribonuclease pancreatic RNASE1 0.0035
897 Glutathione S-transferase kappa 1 GSTK1 0.0035
6034 Hydroxyindole O-methyltransferase ASMT 0.0035
898 Glutathione S-transferase A3 GSTA3 0.0035
6035 Nuclear receptor ROR-beta RORB 0.0035
997 Protein kinase C beta type PRKCB 0.0035
6036 Eosinophil peroxidase EPX 0.0035
3808 Dihydropteroate synthase 2 folP2 0.0035
3601 Dihydropteroate synthase 1 folP1 0.0035
3807 Dihydropteroate synthase 1 folP1 0.0035
2112 Toll-like receptor 9 TLR9 0.0035
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0035
6837 Serine/threonine-protein kinase 17B STK17B 0.0035
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0035
909 Maleylacetoacetate isomerase GSTZ1 0.0035
1025 Aquaporin-1 AQP1 0.0035
939 50S ribosomal protein L3 rplC 0.0035
719 Retinoic acid receptor responder protein 1 RARRES1 0.0034
899 Glutathione S-transferase Mu 3 GSTM3 0.0034
905 Glutathione transferase omega-1 GSTO1 0.0034
770 Retinoic acid-induced protein 3 GPRC5A 0.0034
4031 Glutathione S-transferase A1 GSTA1 0.0034
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0033
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0033
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0033
1970 Protein kinase C alpha type PRKCA 0.0033
233 Potassium channel subfamily K member 2 KCNK2 0.0033
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0033
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0033
6459 Glycodelin PAEP 0.0033
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0033
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0033
5880 Thrombopoietin receptor MPL 0.0033
6500 Phospholipase A2 PLA2G1B 0.0032
387 Amiloride-sensitive amine oxidase [copper-containing] ABP1 0.0032
7187 Amiloride-sensitive amine oxidase [copper-containing] ABP1 0.0032
174 Sigma 1-type opioid receptor SIGMAR1 0.0032
2107 Microtubule-associated protein 1A MAP1A 0.0032
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0032
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0032
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0032
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0032
595 Fibrinogen alpha chain FGA 0.0032
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0032
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0032
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0031
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0031
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0031
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0031
827 Sodium/hydrogen exchanger 1 SLC9A1 0.0031
2165 Glutathione S-transferase Mu 2 GSTM2 0.0031
3086 Plasmepsin-2 Not Available 0.0031
1227 Cytochrome b MT-CYB 0.0031
6386 Cytochrome b petB 0.0031
6937 Cytochrome b MT-CYB 0.0031
674 Dihydroorotate dehydrogenase homolog, mitochondrial PFF0160c 0.0031
765 Indoleamine 2,3-dioxygenase IDO1 0.0031
207 Glutathione synthetase GSS 0.0031
5269 Glutathione synthetase gshB 0.0031
2578 Tubulin beta-3 chain TUBB3 0.003
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
283 SEC14-like protein 2 SEC14L2 0.003
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.003
569 Retinal dehydrogenase 2 ALDH1A2 0.003
1268 Neuropeptide S receptor NPSR1 0.003
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.003
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.003
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.003
734 D1 dopamine receptor-interacting protein calcyon CALY 0.003
654 Flavin reductase BLVRB 0.0029
3813 Fibrinogen gamma chain FGG 0.0029
3812 Fibrinogen beta chain [Contains: Fibrinopeptide B] FGB 0.0029
3950 Cell division protein kinase 9 CDK9 0.0029
3968 Cell division protein kinase 8 CDK8 0.0029
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0029
2236 Casein kinase II subunit alpha CSNK2A1 0.0029
901 Glutathione S-transferase Mu 4 GSTM4 0.0029
611 Retinal dehydrogenase 1 ALDH1A1 0.0028
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0028
605 Fumarate reductase flavoprotein subunit frdA 0.0028
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0028
3673 Fumarate reductase flavoprotein subunit fccA 0.0028
4912 Fumarate reductase flavoprotein subunit ifcA 0.0028
6549 Fumarate reductase flavoprotein subunit frdA 0.0028
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0028
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0028
291 Nitric-oxide synthase, endothelial NOS3 0.0028
1278 Pro-epidermal growth factor EGF 0.0028
1200 AMBP protein AMBP 0.0028
3866 Serum amyloid A protein SAA1 0.0028
1932 Apolipoprotein E APOE 0.0028
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0027
6232 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short GNAS 0.0027
6233 Adenylate cyclase type 2 ADCY2 0.0027
1063 Signal transducer and activator of transcription 5B STAT5B 0.0027
6234 Adenylate cyclase type 5 ADCY5 0.0027
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0027
1144 Hepatocyte growth factor receptor MET 0.0027
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0027
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
6073 Potassium channel subfamily K member 9 KCNK9 0.0027
6072 Potassium channel subfamily K member 3 KCNK3 0.0027
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0027
2159 Quinone oxidoreductase CRYZ 0.0027
760 Fibroblast growth factor 1 FGF1 0.0027
1262 Corticotropin-lipotropin POMC 0.0027
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0026
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0026
6228 Nuclear receptor coactivator 1 NCOA1 0.0026
822 Aldose reductase AKR1B1 0.0026
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0026
484 Tyrosine-protein kinase ABL2 ABL2 0.0025
3959 Cell division protein kinase 4 CDK4 0.0025
714 Glutathione reductase, mitochondrial GSR 0.0025
1385 Angiotensin-converting enzyme 2 ACE2 0.0025
3913 Glutamic acid decarboxylase GAD65 0.0025
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0025
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0025
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0025
3482 Cell division protein kinase 7 CDK7 0.0025
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0025
109 Mitochondrial carnitine/acylcarnitine carrier protein CACL SLC25A29 0.0025
636 Mitochondrial carnitine/acylcarnitine carrier protein SLC25A20 0.0025
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0024
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
6231 Pepsin A PGA3 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
6048 Troponin C, skeletal muscle TNNC2 0.0024
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0023
3955 Cell division protein kinase 6 CDK6 0.0023
4221 Vascular endothelial growth factor VEGF 0.0023
5816 Cadherin-5 CDH5 0.0023
6241 Nuclear receptor coactivator 2 NCOA2 0.0023
2240 Cell division protein kinase 2 CDK2 0.0023
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0022
3014 Ribonuclease UK114 HRSP12 0.0022
3718 Hydrogen peroxide-inducible genes activator oxyR 0.0022
3617 Non-heme chloroperoxidase cpo 0.0022
5426 Non-heme chloroperoxidase cpo 0.0022
5428 Replication protein repA 0.0022
5427 Hydroxyquinol 1,2-dioxygenase chqB 0.0022
3018 HTH-type transcriptional regulator malT malT 0.0022
2232 Interleukin-5 IL5 0.0022
298 Renin REN 0.0021
1593 Mucin-2 MUC2 0.0021
6506 Stathmin-4 STMN4 0.0021
735 Alanine aminotransferase 1 GPT 0.0021
3904 Alanine aminotransferase 2 GPT2 0.0021
551 Carnitine O-acetyltransferase CRAT 0.0021
412 Peroxisomal carnitine O-octanoyltransferase CROT 0.0021
331 Retinol-binding protein I, cellular RBP1 0.0021
3090 Chitosanase csn 0.002
4149 Nuclear factor NF-kappa-B p100 subunit NFKB2 0.002
1742 D-HSCDK2 CDK2deltaT 0.002
1771 Cell division control protein 2 homolog CDK1 0.002
3321 Cell division control protein 2 homolog CRK2 0.002
400 Coagulation factor IX F9 0.002
5461 Coagulation factor IX F9 0.002
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.002
6755 Poliovirus receptor PVR 0.002
1058 Cell division protein kinase 5 CDK5 0.002
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.002
3929 Phosphoethanolamine/phosphocholine phosphatase PHOSPHO1 0.0019
3926 Choline transporter-like protein 2 SLC44A2 0.0019
3925 Choline transporter-like protein 4 SLC44A4 0.0019
549 Choline-phosphate cytidylyltransferase B PCYT1B 0.0019
3933 Choline/ethanolaminephosphotransferase CEPT1 0.0019
3927 Choline transporter-like protein 3 SLC44A3 0.0019
1686 Choline transporter-like protein 1 SLC44A1 0.0019
861 Choline kinase alpha CHKA 0.0019
769 High-affinity choline transporter 1 SLC5A7 0.0019
700 Choline dehydrogenase, mitochondrial CHDH 0.0019
264 Choline/ethanolamine kinase [Includes: Choline kinase beta CHKB 0.0019
576 Choline O-acetyltransferase CHAT 0.0019
3922 Phospholipase D2 PLD2 0.0019
3924 Phospholipase D1 PLD1 0.0019
1074 Urokinase-type plasminogen activator PLAU 0.0019
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0019
2958 Probable tautomerase ydcE pptA 0.0019
2573 Cocaine esterase cocE 0.0019
7263 Cocaine esterase Not Available 0.0019
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0019
2936 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0019
5184 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0019
3115 Ras-related protein Rab-9 RAB9A 0.0019
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0018
3603 Chlorocatechol 1,2-dioxygenase clcA 0.0018
1253 Interferon gamma IFNG 0.0018
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0018
604 Vitamin K-dependent protein Z PROZ 0.0018
5998 Toll-like receptor 8 TLR8 0.0018
712 Tubulin alpha chain TUB1 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
565 Extracellular calcium-sensing receptor CASR 0.0018
3312 Fatty acid-binding protein, brain FABP7 0.0018
1123 Eosinophil cationic protein RNASE3 0.0018
613 Atrial natriuretic peptide receptor A NPR1 0.0017
1374 Natriuretic peptides B NPPB 0.0017
1827 Gap junction alpha-1 protein GJA1 0.0017
1908 Vascular cell adhesion protein 1 VCAM1 0.0017
144 Hemoglobin subunit alpha HBA1 0.0017
1245 Vitamin K-dependent protein S PROS1 0.0017
422 Vitamin K-dependent protein C PROC 0.0017
820 Glycine receptor subunit alpha-2 GLRA2 0.0016
6766 O-GlcNAcase BT_4395 BT_4395 0.0016
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0016
173 Toll-like receptor 7 TLR7 0.0016
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0016
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0016
2297 Genome polyprotein Not Available 0.0016
2322 Genome polyprotein Not Available 0.0016
2694 Genome polyprotein Not Available 0.0016
2719 Genome polyprotein Not Available 0.0016
2860 Genome polyprotein Not Available 0.0016
2928 Genome polyprotein Not Available 0.0016
3160 Genome polyprotein Not Available 0.0016
3260 Genome polyprotein Not Available 0.0016
4783 Genome polyprotein Not Available 0.0016
5726 Genome polyprotein Not Available 0.0016
5779 Genome polyprotein Not Available 0.0016
5867 Genome polyprotein Not Available 0.0016
6253 Genome polyprotein Not Available 0.0016
6301 Genome polyprotein Not Available 0.0016
6380 Genome polyprotein Not Available 0.0016
6381 Genome polyprotein Not Available 0.0016
6437 Genome polyprotein Not Available 0.0016
6520 Genome polyprotein Not Available 0.0016
6521 Genome polyprotein Not Available 0.0016
6652 Genome polyprotein Not Available 0.0016
6734 Genome polyprotein Not Available 0.0016
6735 Genome polyprotein Not Available 0.0016
6736 Genome polyprotein Not Available 0.0016
6737 Genome polyprotein Not Available 0.0016
6738 Genome polyprotein Not Available 0.0016
6739 Genome polyprotein Not Available 0.0016
6744 Genome polyprotein Not Available 0.0016
6748 Genome polyprotein Not Available 0.0016
6894 Genome polyprotein Not Available 0.0016
6898 Genome polyprotein Not Available 0.0016
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0015
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0015
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0015
1569 G1/S-specific cyclin-D1 CCND1 0.0015
2693 Heat-labile enterotoxin B chain eltB 0.0014
4674 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase cumD 0.0014
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0014
2129 Sucrase-isomaltase, intestinal SI 0.0014
6645 D-amino-acid oxidase DAO 0.0014
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.0014
3221 Cytochrome c4 cc4 0.0014
76 Nitric-oxide synthase, brain NOS1 0.0014
798 Osteocalcin BGLAP 0.0014
1152 Glycogen phosphorylase, muscle form PYGM 0.0013
4010 Mitochondrial dicarboxylate carrier SLC25A10 0.0013
1410 Oxidoreductase HSD17B6 0.0013
4725 Oxidoreductase Not Available 0.0013
5124 Oxidoreductase Not Available 0.0013
4007 Succinate receptor 1 SUCNR1 0.0013
4008 Succinyl-CoA:3-ketoacid-coenzyme A transferase 2, mitochondrial OXCT2 0.0013
4002 Succinyl-CoA ligase [GDP-forming] subunit alpha, mitochondrial SUCLG1 0.0013
673 Solute carrier family 13 member 3 SLC13A3 0.0013
391 Succinyl-CoA ligase [GDP-forming] beta-chain, mitochondrial SUCLG2 0.0013
4009 Succinyl-CoA ligase [ADP-forming] beta-chain, mitochondrial SUCLA2 0.0013
498 Solute carrier family 13 member 2 SLC13A2 0.0013
25 Solute carrier family 13 member 1 SLC13A1 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
369 Coagulation factor VII F7 0.0012
3823 Cytokine receptor common gamma chain IL2RG 0.0012
1295 Fatty acid synthase FASN 0.0012
4948 Cytochrome c-553 Not Available 0.0012
4923 Cytochrome c3 DvMF_2499 0.0012
4945 Cytochrome c3 Not Available 0.0012
4949 Cytochrome c3 DVU_3171 0.0012
4968 Cytochrome c3 cytc3 0.0012
4997 Cytochrome c3 SO_2727 0.0012
5219 Cytochrome c3 cyd 0.0012
4902 Nine-heme cytochrome c Ddes_2038 0.0012
3189 High-molecular-weight cytochrome c hmcA 0.0012
4003 Succinyl-CoA:3-ketoacid-coenzyme A transferase 1, mitochondrial OXCT1 0.0012
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0012
6859 Protein S100-A4 S100A4 0.0012
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
4000 Prolyl 4-hydroxylase subunit alpha-2 P4HA2 0.0011
585 Aspartyl/asparaginyl beta-hydroxylase ASPH 0.0011
3940 Gamma-butyrobetaine dioxygenase BBOX1 0.0011
97 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 PLOD1 0.0011
3938 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 PLOD3 0.0011
3964 Trimethyllysine dioxygenase, mitochondrial TMLHE 0.0011
4006 Succinate dehydrogenase cytochrome b560 subunit, mitochondrial SDHC 0.0011
4001 Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial SDHB 0.0011
724 Interleukin-2 receptor alpha chain IL2RA 0.0011
717 Interleukin-2 receptor subunit beta IL2RB 0.0011
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
4228 Keratin, type II cytoskeletal 7 KRT7 0.001
3949 Prolyl 3-hydroxylase 2 LEPREL1 0.001
3945 Prolyl 3-hydroxylase 1 LEPRE1 0.001
3951 Prolyl 3-hydroxylase 3 LEPREL2 0.001
4386 Hemoglobin-like protein HbN glbN 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
3999 Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial SDHD 0.001
512 DNA-directed RNA polymerase alpha chain rpoA 0.001
5772 DNA-directed RNA polymerase alpha chain rpoA 0.001
1176 Mitogen-activated protein kinase 1 MAPK1 0.001
197 Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial SDHA 0.001
2473 Tyrosine-protein kinase CSK CSK 0.001
2398 Tyrosine-protein kinase ZAP-70 ZAP70 0.001
2268 Cholesterol oxidase choB 0.0009
2822 Cholesterol oxidase choA 0.0009
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0009
1048 Protein S100-A13 S100A13 0.0009
2226 Protein S100-A12 S100A12 0.0009
2283 Steroid Delta-isomerase ksi 0.0009
2920 Steroid Delta-isomerase ksi 0.0009
390 Adenosine A3 receptor ADORA3 0.0009
2132 Protein S100-B S100B 0.0009
3404 Exotoxin A eta 0.0008
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0008
4954 Soluble cytochrome b558 Not Available 0.0008
4943 Cytochrome c6 petJ 0.0008
4916 Cyanoglobin glbN 0.0008
4947 Bacterial hemoglobin vhb 0.0008
4934 Cytochrome c-551 nirM 0.0008
5218 Cytochrome c-551 nirM 0.0008
4915 Cytochrome c-550 psbV 0.0008
4959 Cytochrome c-550 psbV 0.0008
5216 Cytochrome c-550 psbV 0.0008
4925 Cytochrome c-type protein SHP shp 0.0008
5000 HemO hemO 0.0008
4975 Cytochrome c-556 RPA3973 0.0008
4936 Cytochrome c2 iso-2 Not Available 0.0008
4994 Hemoglobin-like protein HbO glbO 0.0008
4905 Cytochrome c2 Not Available 0.0008
4939 Cytochrome c2 cycA 0.0008
4964 Cytochrome c2 cycA 0.0008
4979 Cytochrome c2 cycA 0.0008
6673 Cytochrome c2 cycA 0.0008
4942 Diheme cytochrome c napB napB 0.0008
4984 Neuroglobin NGB 0.0008
4981 Iron-starvation protein PigA pigA 0.0008
4998 Hemoglobin-like protein yjbI yjbI 0.0008
4935 Cytochrome c-554 cycA1 0.0008
4909 CooA protein cooA 0.0008
4910 Cytoglobin CYGB 0.0008
4961 Hemophore HasA hasA 0.0008
4904 Cytochrome c family protein GSU1996 0.0008
644 Heme oxygenase 2 HMOX2 0.0008
4982 Heme oxygenase 2 pbsA2 0.0008
4971 Nonaheme cytochrome c hmcA 0.0008
4907 Cytochrome c-L moxG 0.0008
6865 Cytochrome c-L moxG 0.0008
4937 Cytochrome oxidase subunit II rcoxA 0.0008
4989 Cytochrome c551 peroxidase ccp 0.0008
5222 Cytochrome c551 peroxidase ccpA 0.0008
4931 Cytochrome P450 167A1 CYP167A1 0.0008
4976 Apocytochrome f petA 0.0008
6407 Apocytochrome f petA 0.0008
4764 Cytochrome P450 165C4 CYP165C4 0.0008
4999 Cytochrome P450 165B3 CYP165B3 0.0008
4960 Putative cytochrome P450-family protein SCO7417 0.0008
4903 Methyl-accepting chemotaxis protein Tar4 0.0008
4922 Cytochrome c, putative SO_4144 0.0008
4926 Heme-based aerotactic transducer hemAT hemAT 0.0008
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0008
4972 P450cin cinA 0.0008
4993 Hydroxylamine oxidoreductase hao1 0.0008
4952 Catalase/peroxidase katA 0.0008
3093 Catalase HPII katE 0.0008
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
2530 Protein kinase C theta type PRKCQ 0.0008
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0008
2091 Endoplasmin HSP90B1 0.0008
473 L-lactate dehydrogenase A chain LDHA 0.0007
6316 ADP-ribosylation factor 1 ARF1 0.0007
6134 Sodium channel subunit beta-3 SCN3B 0.0007
6133 Sodium channel subunit beta-2 SCN2B 0.0007
6135 Sodium channel subunit beta-4 SCN4B 0.0007
6132 Sodium channel subunit beta-1 SCN1B 0.0007
6129 Carbonic anhydrase-related protein 11 CA11 0.0007
6127 Carbonic anhydrase-related protein CA8 0.0007
6128 Carbonic anhydrase-related protein 10 CA10 0.0007
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0007
2290 ADP-ribosyl cyclase 2 BST1 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0006
6130 Carbonic anhydrase 13 CA13 0.0006
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0006
4920 Peroxidase/catalase katG 0.0006
2119 Cytochrome b5 CYB5A 0.0006
4990 PpcA ppcA 0.0006
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0006
3375 Acidic cytochrome c3 Not Available 0.0006
4988 Sulfite oxidase, mitochondrial SUOX 0.0006
2915 Sensor protein fixL fixL 0.0006
4944 Sensor protein fixL fixL 0.0006
3570 Cytochrome P450 152A1 cypC 0.0006
4813 Heme oxygenase hmuO 0.0006
5769 Heme oxygenase Not Available 0.0006
4385 Cytochrome c' Not Available 0.0006
4967 Cytochrome c' cycA 0.0006
5038 Cytochrome c' Not Available 0.0006
5223 Cytochrome c' cycP 0.0006
4289 Cytochrome P450 TT_P0059 0.0006
6262 Cytochrome P450 staP 0.0006
4992 Cytochrome c peroxidase Not Available 0.0006
5221 Cytochrome c3, 13 kDa Not Available 0.0006
3152 Cytochrome c'' cycA 0.0006
5220 Split-Soret cytochrome c Ddes_2150 0.0006
3700 Cytochrome c-552 precursor nrfA 0.0006
1721 Glycogen synthase kinase-3 beta GSK3B 0.0005
3238 Multidrug resistance protein mexA mexA 0.0005
3116 Bacterioferritin bfr 0.0005
4906 Bacterioferritin bfr 0.0005
4965 Bacterioferritin bfr 0.0005
3173 Enolase eno 0.0005
3709 Glycerol uptake facilitator protein glpF 0.0005
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0005
3393 TGF-beta receptor type-2 TGFBR2 0.0005
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0005
6743 Non-fluorescent flavoprotein luxF 0.0005
6753 Apolipoprotein M APOM 0.0005
2528 Fatty acid metabolism regulator protein fadR 0.0005
6740 Fatty acid metabolism regulator protein fadR 0.0005
6752 Guanylyl cyclase-activating protein 1 GUCA1A 0.0005
394 Calcineurin subunit B isoform 1 PPP3R1 0.0005
6742 Recoverin RCVRN 0.0005
6747 Chalcone/stilbene synthase family protein MT1417 0.0005
6741 Peroxisomal 3,2-trans-enoyl-CoA isomerase PECI 0.0005
6522 Hepatocyte nuclear factor 4-alpha HNF4A 0.0005
6751 Gag polyprotein gag 0.0005
6746 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform PPP3CA 0.0005
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0005
6749 Polyprotein Not Available 0.0005
3670 Soluble cytochrome b562 precursor cybC 0.0005
3411 Cytochrome P450 121 cyp121 0.0005
3291 Cytochrome c-552 cycA 0.0005
4927 Cytochrome c-552 nrfA 0.0005
4938 Cytochrome c-552 cycA 0.0005
4953 Cytochrome c-552 nrfA 0.0005
5217 Cytochrome c-552 cycM 0.0005
2617 Nitric oxide synthase oxygenase nos 0.0005
2701 Nitric oxide synthase oxygenase nos 0.0005
3102 Flavohemoprotein hmp 0.0005
4969 Flavohemoprotein hmp 0.0005
3127 Nitrite reductase nirS 0.0005
3284 Nitrite reductase nirS 0.0005
2852 DNA mismatch repair protein mutL mutL 0.0005
5961 Insulin INS 0.0005
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0005
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0005
6527 Lymphocyte antigen 96 LY96 0.0005
3191 Histidinol dehydrogenase hisD 0.0005
2972 6-deoxyerythronolide B hydroxylase eryF 0.0005
4608 Putative cytochrome P450 SCO1207 0.0004
4963 Putative cytochrome P450 SCO2884 0.0004
6254 Putative cytochrome P450 SCO6998 0.0004
3405 Quinohaemoprotein ethanol dehydrogenase type-1 qheDH 0.0004
6750 ADP-ribosylation factor 6 ARF6 0.0004
4373 Medium-chain-fatty-acid--CoA ligase Not Available 0.0004
4692 A/G-specific adenine glycosylase mutY 0.0004
6524 Protein tonB tonB 0.0004
358 Cystathionine beta-synthase CBS 0.0004
2435 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase lpxC 0.0004
6613 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase lpxC 0.0004
693 Hemoglobin subunit beta HBB 0.0004
2802 Endoglucanase G celCCG 0.0004
340 Apoptotic protease-activating factor 1 APAF1 0.0004
6268 Hydroxyacid oxidase 1 HAO1 0.0004
810 Heme oxygenase 1 HMOX1 0.0004
3391 Heme oxygenase 1 pbsA1 0.0004
864 Gag-Pol polyprotein gag-pol 0.0003
2237 Gag-Pol polyprotein gag-pol 0.0003
2326 Gag-Pol polyprotein gag-pol 0.0003
2451 Gag-Pol polyprotein gag-pol 0.0003
2901 Gag-Pol polyprotein gag-pol 0.0003
3165 Gag-Pol polyprotein gag-pol 0.0003
3722 Gag-Pol polyprotein gag-pol 0.0003
6306 Gag-Pol polyprotein gag-pol 0.0003
6624 Gag-Pol polyprotein gag-pol 0.0003
825 Arsenical pump-driving ATPase ASNA1 0.0003
3435 Arsenical pump-driving ATPase arsA 0.0003
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0003
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0003
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0003
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0003
733 Activin receptor type 1B ACVR1B 0.0003
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0003
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0003
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0003
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0003
154 AFG3-like protein 2 AFG3L2 0.0003
395 ALK tyrosine kinase receptor Not Available 0.0003
292 Activin receptor type-1 ACVR1 0.0003
849 Activated CDC42 kinase 1 TNK2 0.0003
2427 Ferrichrome-iron receptor fhuA 0.0003
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0003
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0003
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0003
297 Adenylate cyclase type 1 ADCY1 0.0003
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0003
6264 cAMP-dependent protein kinase inhibitor alpha PKIA 0.0003
740 Argininosuccinate synthase ASS1 0.0002
865 Argininosuccinate synthase ASS1 0.0002
2680 Argininosuccinate synthase argG 0.0002
3194 Argininosuccinate synthase argG 0.0002
661 ADP/ATP translocase 1 SLC25A4 0.0002
6021 Adenosine kinase ADK 0.0002
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0002
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