DT-Web

DB01544 - Flunitrazepam


Identification
Name Flunitrazepam
Accession Number DB01544
Type small molecule
Description A benzodiazepine with pharmacologic actions similar to those of diazepam that can cause anterograde amnesia. Some reports indicate that it is used as a date rape drug and suggest that it may precipitate violent behavior. The United States Government has banned the importation of this drug. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 313.2832
Groups illicit
Monoisotopic Weight 313.08626947
Pharmacology
Indication For short-term treatment of severe insomnias, that are not responsive to other hypnotics.
Mechanism of action Benzodiazepines bind nonspecifically to benzodiazepine receptors BNZ1, which mediates sleep, and BNZ2, which affects affects muscle relaxation, anticonvulsant activity, motor coordination, and memory. As benzodiazepine receptors are thought to be coupled to gamma-aminobutyric acid-A (GABAA) receptors, this enhances the effects of GABA by increasing GABA affinity for the GABA receptor. Binding of the inhibitory neurotransmitter GABA to the site opens the chloride channel, resulting in a hyperpolarized cell membrane that prevents further excitation of the cell.
Absorption 50% (suppository) and 64-77% (oral)
Protein binding Not Available
Biotransformation Hepatic.
Route of elimination Not Available
Toxicity Symptoms of overdose include confusion, coma, impaired coordination, sleepiness, and slowed reaction time.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Clozapine Increased risk of toxicity
Food Interactions
  • Take with food.
  • Avoid excessive quantities of coffee or tea (Caffeine).
  • Avoid alcohol.
  • Avoid taking with grapefruit juice.

Targets


Translocator protein
Name Translocator protein
Gene Name TSPO
Pharmacological action yes
Actions agonist
References
  • Katz Y, Weizman R, Weizman A, Gavish M: Disulfiram and diethyldithiocarbamate are competitive inhibitors at the peripheral benzodiazepine receptor. J Pharmacol Exp Ther. 1992 Jul;262(1):394-7. - Pubmed
  • Papadopoulos V, Berkovich A, Krueger KE, Costa E, Guidotti A: Diazepam binding inhibitor and its processing products stimulate mitochondrial steroid biosynthesis via an interaction with mitochondrial benzodiazepine receptors. Endocrinology. 1991 Sep;129(3):1481-8. - Pubmed
  • Papadopoulos V, Nowzari FB, Krueger KE: Hormone-stimulated steroidogenesis is coupled to mitochondrial benzodiazepine receptors. Tropic hormone action on steroid biosynthesis is inhibited by flunitrazepam. J Biol Chem. 1991 Feb 25;266(6):3682-7. - Pubmed
  • Awad M, Gavish M: Solubilization of peripheral-type benzodiazepine binding sites from cat cerebral cortex. J Neurochem. 1989 Jun;52(6):1880-5. - Pubmed
  • Gandolfo P, Patte C, Leprince J, Thoumas JL, Vaudry H, Tonon MC: The stimulatory effect of the octadecaneuropeptide (ODN) on cytosolic Ca2+ in rat astrocytes is not mediated through classical benzodiazepine receptors. Eur J Pharmacol. 1997 Mar 19;322(2-3):275-81. - Pubmed
  • Poisnel G, Dhilly M, Le Boisselier R, Barre L, Debruyne D: Comparison of five benzodiazepine-receptor agonists on buprenorphine-induced mu-opioid receptor regulation. J Pharmacol Sci. 2009 May;110(1):36-46. - Pubmed
DTHybrid score 0.3341
Gamma-aminobutyric-acid receptor subunit alpha-2
Name Gamma-aminobutyric-acid receptor subunit alpha-2
Gene Name GABRA2
Pharmacological action yes
Actions potentiator
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Oelschlager H: [Chemical and pharmacologic aspects of benzodiazepines] Schweiz Rundsch Med Prax. 1989 Jul 4;78(27-28):766-72. - Pubmed
  • Oblak AL, Gibbs TT, Blatt GJ: Reduced GABA(A) receptors and benzodiazepine binding sites in the posterior cingulate cortex and fusiform gyrus in autism. Brain Res. 2010 Sep 18. - Pubmed
  • You H, Kozuska JL, Paulsen IM, Dunn SM: Benzodiazepine modulation of the rat GABAA receptor alpha4beta3gamma2L subtype expressed in Xenopus oocytes. Neuropharmacology. 2010 Nov;59(6):527-33. Epub 2010 Jul 16. - Pubmed
  • Skilbeck KJ, O'Reilly JN, Johnston GA, Hinton T: Antipsychotic drug administration differentially affects [3H]muscimol and [3H]flunitrazepam GABA(A) receptor binding sites. Prog Neuropsychopharmacol Biol Psychiatry. 2008 Feb 15;32(2):492-8. Epub 2007 Oct 10. - Pubmed
DTHybrid score 0.5388
Gamma-aminobutyric-acid receptor subunit alpha-4
Name Gamma-aminobutyric-acid receptor subunit alpha-4
Gene Name GABRA4
Pharmacological action yes
Actions agonist
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Oblak AL, Gibbs TT, Blatt GJ: Reduced GABA(A) receptors and benzodiazepine binding sites in the posterior cingulate cortex and fusiform gyrus in autism. Brain Res. 2010 Sep 18. - Pubmed
  • You H, Kozuska JL, Paulsen IM, Dunn SM: Benzodiazepine modulation of the rat GABAA receptor alpha4beta3gamma2L subtype expressed in Xenopus oocytes. Neuropharmacology. 2010 Nov;59(6):527-33. Epub 2010 Jul 16. - Pubmed
  • Skilbeck KJ, O'Reilly JN, Johnston GA, Hinton T: Antipsychotic drug administration differentially affects [3H]muscimol and [3H]flunitrazepam GABA(A) receptor binding sites. Prog Neuropsychopharmacol Biol Psychiatry. 2008 Feb 15;32(2):492-8. Epub 2007 Oct 10. - Pubmed
DTHybrid score 0.466
Gamma-aminobutyric-acid receptor subunit alpha-5
Name Gamma-aminobutyric-acid receptor subunit alpha-5
Gene Name GABRA5
Pharmacological action yes
Actions potentiator
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Oblak AL, Gibbs TT, Blatt GJ: Reduced GABA(A) receptors and benzodiazepine binding sites in the posterior cingulate cortex and fusiform gyrus in autism. Brain Res. 2010 Sep 18. - Pubmed
  • You H, Kozuska JL, Paulsen IM, Dunn SM: Benzodiazepine modulation of the rat GABAA receptor alpha4beta3gamma2L subtype expressed in Xenopus oocytes. Neuropharmacology. 2010 Nov;59(6):527-33. Epub 2010 Jul 16. - Pubmed
DTHybrid score 0.5392
Gamma-aminobutyric-acid receptor subunit alpha-6
Name Gamma-aminobutyric-acid receptor subunit alpha-6
Gene Name GABRA6
Pharmacological action yes
Actions potentiator
References
  • Santhakumar V, Hanchar HJ, Wallner M, Olsen RW, Otis TS: Contributions of the GABAA receptor alpha6 subunit to phasic and tonic inhibition revealed by a naturally occurring polymorphism in the alpha6 gene. J Neurosci. 2006 Mar 22;26(12):3357-64. - Pubmed
  • You H, Kozuska JL, Paulsen IM, Dunn SM: Benzodiazepine modulation of the rat GABAA receptor alpha4beta3gamma2L subtype expressed in Xenopus oocytes. Neuropharmacology. 2010 Nov;59(6):527-33. Epub 2010 Jul 16. - Pubmed
  • Skilbeck KJ, O'Reilly JN, Johnston GA, Hinton T: Antipsychotic drug administration differentially affects [3H]muscimol and [3H]flunitrazepam GABA(A) receptor binding sites. Prog Neuropsychopharmacol Biol Psychiatry. 2008 Feb 15;32(2):492-8. Epub 2007 Oct 10. - Pubmed
DTHybrid score 0.4601
Gamma-aminobutyric-acid receptor subunit alpha-3
Name Gamma-aminobutyric-acid receptor subunit alpha-3
Gene Name GABRA3
Pharmacological action yes
Actions potentiator
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • You H, Kozuska JL, Paulsen IM, Dunn SM: Benzodiazepine modulation of the rat GABAA receptor alpha4beta3gamma2L subtype expressed in Xenopus oocytes. Neuropharmacology. 2010 Nov;59(6):527-33. Epub 2010 Jul 16. - Pubmed
DTHybrid score 0.5363

Enzymes


Cytochrome P450 2C19
Name Cytochrome P450 2C19
Gene Name CYP2C19
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.5746
UDP-glucuronosyltransferase 2B7
Name UDP-glucuronosyltransferase 2B7
Gene Name UGT2B7
Actions inhibitor
References
  • Thomassin J, Tephly TR: Photoaffinity labeling of rat liver microsomal morphine UDP-glucuronosyltransferase by [3H]flunitrazepam. Mol Pharmacol. 1990 Sep;38(3):294-8. - Pubmed
  • Cheng Z, Rios GR, King CD, Coffman BL, Green MD, Mojarrabi B, Mackenzie PI, Tephly TR: Glucuronidation of catechol estrogens by expressed human UDP-glucuronosyltransferases (UGTs) 1A1, 1A3, and 2B7. Toxicol Sci. 1998 Sep;45(1):52-7. - Pubmed
DTHybrid score 0.2911
Cytochrome P450 1A2
Name Cytochrome P450 1A2
Gene Name CYP1A2
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.5501
Cytochrome P450 2A6
Name Cytochrome P450 2A6
Gene Name CYP2A6
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3927
Cytochrome P450 2B6
Name Cytochrome P450 2B6
Gene Name CYP2B6
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4364
Cytochrome P450 2C9
Name Cytochrome P450 2C9
Gene Name CYP2C9
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.6613
Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.8269
Cytochrome P450 2E1
Name Cytochrome P450 2E1
Gene Name CYP2E1
Actions inhibitor
References
  • Tassaneeyakul W, Birkett DJ, Miners JO: Inhibition of human hepatic cytochrome P4502E1 by azole antifungals, CNS-active drugs and non-steroidal anti-inflammatory agents. Xenobiotica. 1998 Mar;28(3):293-301. - Pubmed
DTHybrid score 0.4305
UDP-glucuronosyltransferase 1-1
Name UDP-glucuronosyltransferase 1-1
Gene Name UGT1A1
Actions inhibitor
References
  • Cheng Z, Rios GR, King CD, Coffman BL, Green MD, Mojarrabi B, Mackenzie PI, Tephly TR: Glucuronidation of catechol estrogens by expressed human UDP-glucuronosyltransferases (UGTs) 1A1, 1A3, and 2B7. Toxicol Sci. 1998 Sep;45(1):52-7. - Pubmed
DTHybrid score 0.3016
UDP-glucuronosyltransferase 1-3
Name UDP-glucuronosyltransferase 1-3
Gene Name UGT1A3
Actions inhibitor
References
  • Cheng Z, Rios GR, King CD, Coffman BL, Green MD, Mojarrabi B, Mackenzie PI, Tephly TR: Glucuronidation of catechol estrogens by expressed human UDP-glucuronosyltransferases (UGTs) 1A1, 1A3, and 2B7. Toxicol Sci. 1998 Sep;45(1):52-7. - Pubmed
DTHybrid score 0.2674

Predictions


Id Partner name Gene Name Score
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.5035
4924 Cytochrome P450 2C8 CYP2C8 0.4004
4119 Cytochrome P450 2D6 CYP2D6 0.3763
1588 Multidrug resistance protein 1 ABCB1 0.3377
4118 Cytochrome P450 3A5 CYP3A5 0.2755
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.27
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.2699
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.2613
921 Glutamate receptor 2 GRIA2 0.2279
6107 Cytochrome P450 3A7 CYP3A7 0.2062
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.2048
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.201
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.1983
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.1979
20 Prostaglandin G/H synthase 1 PTGS1 0.1974
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.1961
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.1951
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.1949
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.1875
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.1869
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.1867
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.1865
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.1834
6024 Cytochrome P450 1A1 CYP1A1 0.1702
587 Serum albumin ALB 0.152
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.1518
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.132
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.1121
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.106
6106 Cytochrome P450 2C18 CYP2C18 0.1
290 Prostaglandin G/H synthase 2 PTGS2 0.0966
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0957
1729 Solute carrier family 22 member 6 SLC22A6 0.0845
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0728
492 Histamine H1 receptor HRH1 0.0706
3811 Cytochrome P450 19A1 CYP19A1 0.0694
862 Multidrug resistance-associated protein 1 ABCC1 0.0685
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0644
824 Sodium-dependent serotonin transporter SLC6A4 0.0573
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0571
2164 Multidrug resistance-associated protein 4 ABCC4 0.0518
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0513
1898 Cytochrome P450 1B1 CYP1B1 0.051
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.051
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.051
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0501
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0496
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0488
502 5-hydroxytryptamine 2A receptor HTR2A 0.0483
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0468
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0463
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0453
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0446
6145 Solute carrier family 22 member 1 SLC22A1 0.0443
6144 Solute carrier family 22 member 2 SLC22A2 0.0443
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0434
6102 Arylamine N-acetyltransferase 2 NAT2 0.0432
556 Alpha-1A adrenergic receptor ADRA1A 0.0428
847 Mu-type opioid receptor OPRM1 0.0424
776 Bile salt export pump ABCB11 0.0406
467 Delta-type opioid receptor OPRD1 0.04
468 Cytochrome P450 4A11 CYP4A11 0.0398
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0398
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0395
70 Type-1 angiotensin II receptor AGTR1 0.0394
696 Kappa-type opioid receptor OPRK1 0.0392
590 5-hydroxytryptamine 2C receptor HTR2C 0.0391
260 Cytochrome P450 51 ERG11 0.0383
761 Cytochrome P450 51 ERG11 0.0383
3163 Cytochrome P450 51 cyp51 0.0383
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0383
136 Estrogen receptor ESR1 0.0382
6142 Solute carrier family 22 member 8 SLC22A8 0.0375
831 D(2) dopamine receptor DRD2 0.0371
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0354
766 Beta-2 adrenergic receptor ADRB2 0.0348
341 5-hydroxytryptamine 3 receptor HTR3A 0.0343
3941 Amine oxidase [flavin-containing] A MAOA 0.0341
713 Sodium-dependent dopamine transporter SLC6A3 0.0334
6031 Cytochrome P450 3A43 CYP3A43 0.0332
817 DNA topoisomerase 2-alpha TOP2A 0.0329
318 Alpha-2A adrenergic receptor ADRA2A 0.0328
5880 Thrombopoietin receptor MPL 0.0328
118 Organic cation/carnitine transporter 2 SLC22A5 0.0322
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0317
6143 Solute carrier family 22 member 7 SLC22A7 0.031
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0298
632 Alpha-1B adrenergic receptor ADRA1B 0.0294
731 HIV-1 protease HIV-1 protease 0.0291
4604 Liver carboxylesterase 1 CES1 0.029
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0278
23 D(1A) dopamine receptor DRD1 0.0273
3939 Amine oxidase [flavin-containing] B MAOB 0.0271
6026 Alcohol dehydrogenase 6 ADH6 0.0266
465 Calmodulin CALM1 0.0263
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0261
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.026
36 Insulin receptor INSR 0.0258
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0257
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0256
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0256
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0254
146 Androgen receptor AR 0.0253
1024 Solute carrier family 22 member 11 SLC22A11 0.0252
6147 Solute carrier family 22 member 3 SLC22A3 0.0252
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.025
320 5-hydroxytryptamine 1A receptor HTR1A 0.0249
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0244
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0242
6220 Aryl hydrocarbon receptor AHR 0.0242
122 P2Y purinoceptor 12 P2RY12 0.0241
871 Glucocorticoid receptor NR3C1 0.0241
789 Alpha-1D adrenergic receptor ADRA1D 0.0239
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0239
6136 Multidrug resistance-associated protein 5 ABCC5 0.0238
3937 Fatty-acid amide hydrolase FAAH 0.0237
6014 Cytochrome P450 2A13 CYP2A13 0.0234
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0234
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0232
3810 Catechol O-methyltransferase COMT 0.0231
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.023
6020 Aldehyde oxidase AOX1 0.023
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0228
891 Dihydropteroate synthase folP 0.0222
5359 Dihydropteroate synthase folP 0.0222
7175 Dihydropteroate synthase sulI 0.0222
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0215
885 5-hydroxytryptamine 1B receptor HTR1B 0.0214
482 Glycine receptor subunit alpha-1 GLRA1 0.0213
4164 Potassium voltage-gated channel subfamily KQT member 5 KCNQ5 0.0211
4163 Potassium voltage-gated channel subfamily KQT member 4 KCNQ4 0.0211
26 Vascular endothelial growth factor receptor 3 FLT4 0.021
117 Sterol O-acyltransferase 1 SOAT1 0.0205
504 Mast/stem cell growth factor receptor KIT 0.0204
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0203
32 Vascular endothelial growth factor receptor 1 FLT1 0.0201
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0199
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0198
442 Envelope glycoprotein gp41 0.0198
4859 Envelope glycoprotein env 0.0198
3923 Cholinesterase BCHE 0.0194
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0194
407 Vascular endothelial growth factor receptor 2 KDR 0.0188
6141 Sodium/bile acid cotransporter SLC10A1 0.0187
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0187
4122 Histone deacetylase 2 HDAC2 0.0187
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0183
725 5-hydroxytryptamine 1D receptor HTR1D 0.018
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0179
1760 Aminopeptidase N ANPEP 0.0178
6843 Aminopeptidase N pepN 0.0178
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0178
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0178
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0174
537 ATP synthase delta chain, mitochondrial ATP5D 0.0173
3233 Bile acid receptor NR1H4 0.0171
705 Glutamate receptor 1 GRIA1 0.0171
833 Organic cation/carnitine transporter 1 SLC22A4 0.0169
638 D(3) dopamine receptor DRD3 0.0169
1630 Integrin beta-2 ITGB2 0.0167
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0166
193 Beta-1 adrenergic receptor ADRB1 0.0166
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0166
477 DNA topoisomerase 4 subunit A parC 0.0165
886 DNA topoisomerase 4 subunit A parC 0.0165
6226 DNA topoisomerase 4 subunit A parC 0.0165
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0163
404 DNA gyrase subunit A gyrA 0.0163
6224 DNA gyrase subunit A gyrA 0.0163
6137 Multidrug resistance-associated protein 6 ABCC6 0.016
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0159
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0158
16 Adenosine A1 receptor ADORA1 0.0158
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0157
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0156
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0156
6138 Multidrug resistance protein 3 ABCB4 0.0156
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0154
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0153
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0153
777 Tumor necrosis factor TNF 0.0152
6044 Serum paraoxonase/lactonase 3 PON3 0.0152
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0151
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.015
629 Alpha-2B adrenergic receptor ADRA2B 0.0149
459 Retinoic acid receptor RXR-alpha RXRA 0.0147
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0146
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0146
588 Chromodomain-helicase-DNA-binding protein 1 CHD1 0.0144
319 Opioid receptor, sigma 1 OPRS1 0.0142
723 Cytosolic phospholipase A2 PLA2G4A 0.0142
6085 Fatty acid-binding protein, intestinal FABP2 0.0139
228 Beta platelet-derived growth factor receptor PDGFRB 0.0139
869 Estrogen receptor beta ESR2 0.0138
1010 Cytochrome P450 51A1 CYP51A1 0.0137
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0136
6148 Multidrug resistance-associated protein 7 ABCC10 0.0135
818 50S ribosomal protein L10 rplJ 0.0134
1757 Myeloperoxidase MPO 0.0133
844 Epidermal growth factor receptor EGFR 0.013
3809 Estrogen-related receptor gamma ESRRG 0.013
275 Arachidonate 5-lipoxygenase ALOX5 0.0129
378 Alpha-2C adrenergic receptor ADRA2C 0.0127
94 5-hydroxytryptamine 4 receptor HTR4 0.0127
273 Apoptosis regulator Bcl-2 BCL2 0.0124
1178 Adenosine A2a receptor ADORA2A 0.0122
571 Melatonin receptor type 1A MTNR1A 0.0122
362 Melatonin receptor type 1B MTNR1B 0.0122
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0122
251 Alcohol dehydrogenase 1A ADH1A 0.0121
1629 Transcription factor AP-1 JUN 0.0121
267 Plasminogen activator inhibitor 1 SERPINE1 0.012
432 D(4) dopamine receptor DRD4 0.0119
716 5-hydroxytryptamine 7 receptor HTR7 0.0119
373 Transthyretin TTR 0.0118
2021 Thrombomodulin THBD 0.0117
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0116
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0116
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0115
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0115
444 Alcohol dehydrogenase 1B ADH1B 0.0115
572 Integrin alpha-L ITGAL 0.0115
3947 Xanthine dehydrogenase/oxidase XDH 0.0114
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0113
232 Corticosteroid-binding globulin SERPINA6 0.0113
6182 Cytochrome P450 2J2 CYP2J2 0.0112
436 5-hydroxytryptamine 2B receptor HTR2B 0.0112
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0112
2230 Catalase CAT 0.0112
3249 Catalase katA 0.0112
3625 Catalase katA 0.0112
4539 Catalase katA 0.0112
4941 Catalase katB 0.0112
295 Carbonic anhydrase 1 CA1 0.0111
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.011
592 Carbonic anhydrase 4 CA4 0.011
6221 Steroid hormone receptor ERR1 ESRRA 0.011
756 Sex hormone-binding globulin SHBG 0.0109
172 Potassium channel subfamily K member 1 KCNK1 0.0109
124 Histamine H2 receptor HRH2 0.0109
4120 NADPH--cytochrome P450 reductase POR 0.0107
563 Thyroid peroxidase TPO 0.0106
613 Atrial natriuretic peptide receptor A NPR1 0.0106
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0106
1192 Sulfotransferase 1A1 SULT1A1 0.0106
4116 Dihydropteroate synthetase Not Available 0.0106
1656 CYP2B protein CYP2B 0.0106
54 Prothrombin F2 0.0105
1039 Histone deacetylase 9 HDAC9 0.0103
2981 Phospholipase A2, membrane associated PLA2G2A 0.0103
614 Progesterone receptor PGR 0.0102
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0102
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0101
952 Dipeptidyl peptidase 4 DPP4 0.01
4237 50S ribosomal protein L22 rplV 0.01
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.01
174 Sigma 1-type opioid receptor SIGMAR1 0.0099
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0099
284 DNA-directed RNA polymerase beta chain rpoB 0.0097
5773 DNA-directed RNA polymerase beta chain rpoB 0.0097
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0097
958 Insulin-like growth factor 1 receptor IGF1R 0.0097
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0096
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0096
518 Peroxidase/catalase T katG 0.0096
49 Endothelin B receptor EDNRB 0.0096
427 Substance-P receptor TACR1 0.0095
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0095
517 Alcohol dehydrogenase 1C ADH1C 0.0094
380 Cytochrome P450 17A1 CYP17A1 0.0092
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0092
1275 Estrogen sulfotransferase SULT1E1 0.0092
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0092
6043 Putative G-protein coupled receptor 44 GPR44 0.0091
578 Endothelin-1 receptor EDNRA 0.009
161 Tubulin beta chain TUBB 0.009
312 Tubulin beta chain TUB2 0.009
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0089
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0088
4238 50S ribosomal protein L4 rplD 0.0088
5578 50S ribosomal protein L4 rplD 0.0088
6173 50S ribosomal protein L4 rplD 0.0088
6219 50S ribosomal protein L4 rplD 0.0088
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0088
68 Cannabinoid receptor 1 CNR1 0.0087
3932 Glutathione S-transferase A2 GSTA2 0.0087
823 Fibroblast growth factor receptor 2 FGFR2 0.0087
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0086
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0085
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0084
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.0082
357 Carbonic anhydrase 2 CA2 0.0082
738 Monocarboxylate transporter 1 SLC16A1 0.0081
29 Tubulin beta-1 chain TUBB1 0.0081
1792 Tissue-type plasminogen activator PLAT 0.0081
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.008
1618 High affinity nerve growth factor receptor NTRK1 0.008
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0078
904 Glutathione S-transferase P GSTP1 0.0078
365 Dihydrofolate reductase DHFR 0.0078
2381 Dihydrofolate reductase DFR1 0.0078
2833 Dihydrofolate reductase Not Available 0.0078
2931 Dihydrofolate reductase folA 0.0078
3544 Dihydrofolate reductase folA 0.0078
3682 Dihydrofolate reductase folA 0.0078
6642 Dihydrofolate reductase folA 0.0078
6756 Dihydrofolate reductase dfrA 0.0078
4217 Telomerase reverse transcriptase TERT 0.0077
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0076
6126 Carbonic anhydrase 7 CA7 0.0076
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0076
528 5-hydroxytryptamine 1E receptor HTR1E 0.0075
1050 Bile salt sulfotransferase SULT2A1 0.0073
511 5-hydroxytryptamine 1F receptor HTR1F 0.0073
183 Vascular endothelial growth factor A VEGFA 0.0072
6432 Transporter snf 0.0072
790 DNA polymerase subunit alpha B POLA2 0.0071
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0071
163 D(1B) dopamine receptor DRD5 0.007
84 Nuclear receptor 0B1 NR0B1 0.007
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0069
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0069
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0069
153 Dopamine beta-hydroxylase DBH 0.0068
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0067
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0066
1256 5-hydroxytryptamine 6 receptor HTR6 0.0066
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0064
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0063
908 Glutathione S-transferase theta-1 GSTT1 0.0063
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0063
780 Retinoic acid receptor RXR-gamma RXRG 0.0063
133 Dihydropterate synthase sulI 0.0063
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0062
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0062
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0062
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0062
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0062
106 Cannabinoid receptor 2 CNR2 0.0062
6174 50S ribosomal protein L32 rpmF 0.0061
474 Acetylcholinesterase ACHE 0.0061
2298 Cytochrome P450-cam camC 0.006
2320 Thymidine kinase, cytosolic TK1 0.006
102 DNA topoisomerase I, mitochondrial TOP1MT 0.006
4148 Serine/threonine-protein kinase mTOR MTOR 0.0059
814 Ryanodine receptor 1 RYR1 0.0059
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0058
856 Vitamin D3 receptor VDR 0.0058
88 Retinoic acid receptor RXR-beta RXRB 0.0057
3917 Methylenetetrahydrofolate reductase MTHFR 0.0057
131 Synaptic vesicular amine transporter SLC18A2 0.0057
7 Nitric oxide synthase, inducible NOS2 0.0056
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0055
6042 Prostaglandin reductase 2 PTGR2 0.0054
390 Adenosine A3 receptor ADORA3 0.0053
5998 Toll-like receptor 8 TLR8 0.0053
5798 Mitogen-activated protein kinase 11 MAPK11 0.0052
565 Extracellular calcium-sensing receptor CASR 0.0052
712 Tubulin alpha chain TUB1 0.0052
3856 Fibroblast growth factor receptor 3 FGFR3 0.0052
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0052
3090 Chitosanase csn 0.0052
4149 Nuclear factor NF-kappa-B p100 subunit NFKB2 0.0052
4752 Peroxisomal trans-2-enoyl-CoA reductase PECR 0.0052
2751 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0052
4755 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0052
3823 Cytokine receptor common gamma chain IL2RG 0.0051
4692 A/G-specific adenine glycosylase mutY 0.0051
239 Coagulation factor X F10 0.0051
6146 High affinity copper uptake protein 1 SLC31A1 0.0051
165 FL cytokine receptor FLT3 0.0051
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.005
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.005
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.005
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.005
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.005
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.005
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.005
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.005
4192 DNA topoisomerase 2-beta TOP2B 0.005
936 Ephrin type-A receptor 2 EPHA2 0.005
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.005
1353 DNA topoisomerase 1 TOP1 0.005
3552 DNA topoisomerase 1 topA 0.005
6766 O-GlcNAcase BT_4395 BT_4395 0.0049
24 Thymidylate synthase TMP1 0.0049
359 Thymidylate synthase TYMS 0.0049
2626 Thymidylate synthase thyA 0.0049
2729 Thymidylate synthase thyA 0.0049
5352 Thymidylate synthase THYA 0.0049
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0048
5787 Angiopoietin-1 receptor TEK 0.0048
6288 Low molecular weight phosphotyrosine protein phosphatase ACP1 0.0048
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0047
581 Cytochrome P450 2R1 CYP2R1 0.0047
737 Mineralocorticoid receptor NR3C2 0.0047
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0047
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0047
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0047
6832 Serine/threonine-protein kinase SRPK2 SRPK2 0.0046
1483 Membrane copper amine oxidase AOC3 0.0046
1253 Interferon gamma IFNG 0.0046
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0046
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0046
634 Squalene monooxygenase SQLE 0.0046
7196 Squalene monooxygenase ERG1 0.0046
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0046
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0046
173 Toll-like receptor 7 TLR7 0.0046
992 Protein tyrosine kinase 2 beta PTK2B 0.0045
527 Prostacyclin receptor PTGIR 0.0045
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0045
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0045
724 Interleukin-2 receptor alpha chain IL2RA 0.0045
717 Interleukin-2 receptor subunit beta IL2RB 0.0045
2178 Metabotropic glutamate receptor 5 GRM5 0.0045
820 Glycine receptor subunit alpha-2 GLRA2 0.0045
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0045
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0044
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0044
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0044
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0044
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0044
130 Prostacyclin synthase PTGIS 0.0044
2539 Tubulin alpha-1 chain TUBA4A 0.0043
714 Glutathione reductase, mitochondrial GSR 0.0042
4606 Purine trans deoxyribosylase ptd 0.0042
1648 Elastin ELN 0.0041
1313 Lactoylglutathione lyase GLO1 0.0041
1360 Sphingomyelin phosphodiesterase SMPD1 0.0041
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0041
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0041
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0041
1517 Beta-3 adrenergic receptor ADRB3 0.004
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.004
4311 tRNA TRDMT1 0.004
4325 tRNA trmD 0.004
4328 tRNA trmD 0.004
400 Coagulation factor IX F9 0.004
5461 Coagulation factor IX F9 0.004
3679 MTA/SAH nucleosidase mtnN 0.004
1958 S-methyl-5-thioadenosine phosphorylase MTAP 0.004
976 Platelet glycoprotein IX GP9 0.004
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.004
5934 Cytochrome P450 26A1 CYP26A1 0.004
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.004
775 Acetyl-CoA carboxylase 2 ACACB 0.004
1268 Neuropeptide S receptor NPSR1 0.004
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.004
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.004
564 Cellular retinoic acid-binding protein 1 CRABP1 0.004
469 Annexin A1 ANXA1 0.0039
1541 Metalloproteinase mmp20 0.0039
3808 Dihydropteroate synthase 2 folP2 0.0039
3601 Dihydropteroate synthase 1 folP1 0.0039
3807 Dihydropteroate synthase 1 folP1 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
128 Adenine phosphoribosyltransferase APRT 0.0038
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0038
605 Fumarate reductase flavoprotein subunit frdA 0.0038
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0038
3673 Fumarate reductase flavoprotein subunit fccA 0.0038
4912 Fumarate reductase flavoprotein subunit ifcA 0.0038
6549 Fumarate reductase flavoprotein subunit frdA 0.0038
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0038
85 Growth hormone receptor GHR 0.0038
3639 Thymidine phosphorylase deoA 0.0037
3936 Thymidine phosphorylase TYMP 0.0037
164 Histamine H4 receptor HRH4 0.0037
719 Retinoic acid receptor responder protein 1 RARRES1 0.0037
770 Retinoic acid-induced protein 3 GPRC5A 0.0037
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0037
604 Vitamin K-dependent protein Z PROZ 0.0037
3957 Adenosine deaminase ADA 0.0036
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0036
6073 Potassium channel subfamily K member 9 KCNK9 0.0036
6072 Potassium channel subfamily K member 3 KCNK3 0.0036
633 Penicillin-binding proteins 1A/1B pbpA 0.0036
1636 Trace amine-associated receptor 1 TAAR1 0.0036
3404 Exotoxin A eta 0.0036
65 Matrix metalloproteinase-9 Not Available 0.0035
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0035
185 Vasopressin V1a receptor AVPR1A 0.0035
2449 Tubulin alpha-3 chain TUBA1A 0.0035
1992 Vitamin D-binding protein GC 0.0035
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0035
939 50S ribosomal protein L3 rplC 0.0035
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0034
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0034
322 Vasopressin V2 receptor AVPR2 0.0034
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0034
2499 Tubulin beta-2C chain TUBB2C 0.0034
1245 Vitamin K-dependent protein S PROS1 0.0034
422 Vitamin K-dependent protein C PROC 0.0034
33 Cystine/glutamate transporter SLC7A11 0.0033
4226 Uridine phosphorylase 2 UPP2 0.0033
558 Solute carrier family 12 member 1 SLC12A1 0.0033
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0033
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0033
760 Fibroblast growth factor 1 FGF1 0.0033
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0033
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0033
569 Retinal dehydrogenase 2 ALDH1A2 0.0033
291 Nitric-oxide synthase, endothelial NOS3 0.0032
162 Retinoic acid receptor gamma-1 RARG 0.0032
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0032
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
4203 Histamine N-methyltransferase HNMT 0.0031
1374 Natriuretic peptides B NPPB 0.0031
1827 Gap junction alpha-1 protein GJA1 0.0031
1908 Vascular cell adhesion protein 1 VCAM1 0.0031
473 L-lactate dehydrogenase A chain LDHA 0.0031
1227 Cytochrome b MT-CYB 0.0031
6386 Cytochrome b petB 0.0031
6937 Cytochrome b MT-CYB 0.0031
674 Dihydroorotate dehydrogenase homolog, mitochondrial PFF0160c 0.0031
2264 Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase cobT 0.0031
5300 Antigen peptide transporter 1 TAP1 0.0031
611 Retinal dehydrogenase 1 ALDH1A1 0.0031
4225 Uridine phosphorylase 1 UPP1 0.0031
2578 Tubulin beta-3 chain TUBB3 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
543 Penicillin-binding protein 1B mrcB 0.003
6186 Penicillin-binding protein 1B ponB 0.003
6822 Penicillin-binding protein 1b pbp1b 0.003
6844 Penicillin-binding protein 1b pbp1b 0.003
448 Vitamin K-dependent gamma-carboxylase GGCX 0.003
4228 Keratin, type II cytoskeletal 7 KRT7 0.003
896 Glutathione S-transferase Mu 1 GSTM1 0.0029
159 Penicillin-binding protein 2B penA 0.0029
6121 Penicillin-binding protein 2B penA 0.0029
1196 Complement decay-accelerating factor CD55 0.0029
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0029
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0029
751 Potassium channel subfamily K member 6 KCNK6 0.0029
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0029
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0029
3913 Glutamic acid decarboxylase GAD65 0.0029
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0029
413 Amidophosphoribosyltransferase PPAT 0.0029
2515 Amidophosphoribosyltransferase purF 0.0029
3714 Amidophosphoribosyltransferase purF 0.0029
512 DNA-directed RNA polymerase alpha chain rpoA 0.0029
5772 DNA-directed RNA polymerase alpha chain rpoA 0.0029
2290 ADP-ribosyl cyclase 2 BST1 0.0028
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0028
330 Spermidine synthase SRM 0.0028
3038 Spermidine synthase speE 0.0028
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0028
1200 AMBP protein AMBP 0.0028
3866 Serum amyloid A protein SAA1 0.0028
1932 Apolipoprotein E APOE 0.0028
798 Osteocalcin BGLAP 0.0028
1144 Hepatocyte growth factor receptor MET 0.0027
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0027
2207 Rhodopsin RHO 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
2159 Quinone oxidoreductase CRYZ 0.0027
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0027
6163 Copper-transporting ATPase 2 ATP7B 0.0027
6165 Copper-transporting ATPase 1 ATP7A 0.0027
4103 Proteasome subunit beta type 2 PSMB2 0.0027
4102 Proteasome subunit beta type 5 PSMB5 0.0027
4101 Proteasome subunit beta type 1 PSMB1 0.0027
3849 Insulin-like growth factor-binding protein 7 IGFBP7 0.0027
2009 Protein NOV homolog NOV 0.0027
3847 Neuroendocrine convertase 2 PCSK2 0.0027
1949 Carboxypeptidase E CPE 0.0027
3850 Synaptotagmin-like protein 4 SYTL4 0.0027
3848 Neuroendocrine convertase 1 PCSK1 0.0027
3846 Retinoblastoma-associated protein RB1 0.0027
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0027
268 Adenosine A2b receptor ADORA2B 0.0026
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0026
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0026
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0026
358 Cystathionine beta-synthase CBS 0.0026
2808 Chloramphenicol acetyltransferase 3 cat3 0.0026
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0025
6149 Solute carrier family 22 member 10 SLC22A10 0.0025
3830 Calreticulin CALR 0.0025
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0025
369 Coagulation factor VII F7 0.0025
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0025
768 FK506-binding protein 1A FKBP1A 0.0025
735 Alanine aminotransferase 1 GPT 0.0024
3904 Alanine aminotransferase 2 GPT2 0.0024
334 S-adenosylmethionine synthetase isoform type-2 MAT2A 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
6070 Nischarin NISCH 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
208 DNA-directed RNA polymerase beta' chain rpoC 0.0023
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0023
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0023
6034 Hydroxyindole O-methyltransferase ASMT 0.0023
6035 Nuclear receptor ROR-beta RORB 0.0023
6036 Eosinophil peroxidase EPX 0.0023
2417 Chloramphenicol acetyltransferase cat 0.0023
3278 Chloramphenicol acetyltransferase cat 0.0023
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0023
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0023
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0023
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0023
1830 5'-nucleotidase NT5E 0.0023
2810 Dr hemagglutinin structural subunit draA 0.0023
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.0023
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0023
6131 Carbonic anhydrase 14 CA14 0.0023
1262 Corticotropin-lipotropin POMC 0.0023
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0022
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0022
113 S-adenosylmethionine decarboxylase proenzyme AMD1 0.0022
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0022
411 Glycine N-methyltransferase GNMT 0.0022
2155 Insulin-degrading enzyme IDE 0.0022
2232 Interleukin-5 IL5 0.0022
298 Renin REN 0.0021
1593 Mucin-2 MUC2 0.0021
6506 Stathmin-4 STMN4 0.0021
6122 Carbonic anhydrase 3 CA3 0.0021
2091 Endoplasmin HSP90B1 0.0021
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.0021
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0021
1852 Microtubule-associated protein 2 MAP2 0.0021
828 Phenylalanine-4-hydroxylase PAH 0.0021
3109 Phenylalanine-4-hydroxylase phhA 0.0021
765 Indoleamine 2,3-dioxygenase IDO1 0.002
3611 Cytidine deaminase cdd 0.002
3707 Cytidine deaminase cdd 0.002
4211 Cytidine deaminase CDA 0.002
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.002
1864 RET proto-oncogene RET 0.002
1820 Beta-nerve growth factor NGF 0.002
6103 Arylamine N-acetyltransferase 1 NAT1 0.002
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.002
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.002
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.002
2236 Casein kinase II subunit alpha CSNK2A1 0.0019
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0019
718 Folate receptor gamma FOLR3 0.0019
299 Folate receptor beta FOLR2 0.0019
804 Mitochondrial folate transporter/carrier SLC25A32 0.0019
233 Potassium channel subfamily K member 2 KCNK2 0.0019
3426 Glutamine synthetase glnA 0.0019
3987 Glutamine synthetase GLUL 0.0019
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
683 Potassium transporter GK0582 0.0018
1123 Eosinophil cationic protein RNASE3 0.0018
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0017
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0017
4773 Deoxycytidine kinase DCK 0.0017
3221 Cytochrome c4 cc4 0.0017
293 Gamma-glutamyl hydrolase GGH 0.0017
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0017
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0017
1243 Cathepsin D CTSD 0.0016
2853 14 kDa fatty acid-binding protein Not Available 0.0015
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0015
1714 Mitogen-activated protein kinase 3 MAPK3 0.0015
3844 HLA class II histocompatibility antigen, DQ(6) alpha chain HLA-DQA2 0.0015
1650 Heme carrier protein 1 SLC46A1 0.0015
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0015
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0015
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0015
1341 Histamine H3 receptor HRH3 0.0014
6167 Organic solute transporter subunit beta OSTB 0.0014
6166 Organic solute transporter subunit alpha OSTA 0.0014
6859 Protein S100-A4 S100A4 0.0014
2300 Lysozyme E 0.0014
3633 Lysozyme R 0.0014
5597 Lysozyme 17 0.0014
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0014
3007 Carbonic anhydrase 12 CA12 0.0014
4205 Carbonic anhydrase 9 CA9 0.0014
6218 Pannexin-1 PANX1 0.0013
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0013
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0013
5626 Nucleoside diphosphate kinase B NME2 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
2107 Microtubule-associated protein 1A MAP1A 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
5924 Microtubule-associated protein 4 MAP4 0.0012
5923 Microtubule-associated protein tau MAPT 0.0012
1295 Fatty acid synthase FASN 0.0012
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0012
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0011
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0011
1063 Signal transducer and activator of transcription 5B STAT5B 0.0011
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0011
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0011
2183 Fatty acid-binding protein, adipocyte FABP4 0.0011
6033 High affinity interleukin-8 receptor A CXCR1 0.001
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
3238 Multidrug resistance protein mexA mexA 0.001
3709 Glycerol uptake facilitator protein glpF 0.001
3116 Bacterioferritin bfr 0.001
4906 Bacterioferritin bfr 0.001
4965 Bacterioferritin bfr 0.001
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.001
3173 Enolase eno 0.001
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.001
3393 TGF-beta receptor type-2 TGFBR2 0.001
4948 Cytochrome c-553 Not Available 0.001
4923 Cytochrome c3 DvMF_2499 0.001
4945 Cytochrome c3 Not Available 0.001
4949 Cytochrome c3 DVU_3171 0.001
4968 Cytochrome c3 cytc3 0.001
4997 Cytochrome c3 SO_2727 0.001
5219 Cytochrome c3 cyd 0.001
4902 Nine-heme cytochrome c Ddes_2038 0.001
3189 High-molecular-weight cytochrome c hmcA 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
5294 Nucleoside diphosphate kinase A NME1 0.001
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.001
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
6824 Tyrosine-protein kinase Lyn LYN 0.001
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0009
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0009
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0009
2268 Cholesterol oxidase choB 0.0009
2822 Cholesterol oxidase choA 0.0009
6048 Troponin C, skeletal muscle TNNC2 0.0009
997 Protein kinase C beta type PRKCB 0.0009
6168 Solute carrier family 22 member 16 SLC22A16 0.0009
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0009
484 Tyrosine-protein kinase ABL2 ABL2 0.0009
229 Retinoic acid receptor beta RARB 0.0009
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0009
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0009
3086 Plasmepsin-2 Not Available 0.0009
730 Retinoic acid receptor alpha RARA 0.0009
1048 Protein S100-A13 S100A13 0.0009
2226 Protein S100-A12 S100A12 0.0009
2852 DNA mismatch repair protein mutL mutL 0.0009
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0009
1770 Phospholipase C PLCL1 0.0009
2841 Phospholipase C plc 0.0009
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0009
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0009
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0009
2283 Steroid Delta-isomerase ksi 0.0009
2920 Steroid Delta-isomerase ksi 0.0009
3191 Histidinol dehydrogenase hisD 0.0009
1970 Protein kinase C alpha type PRKCA 0.0009
4386 Hemoglobin-like protein HbN glbN 0.0009
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0009
2132 Protein S100-B S100B 0.0009
2408 Tyrosine-protein kinase SYK SYK 0.0009
740 Argininosuccinate synthase ASS1 0.0009
865 Argininosuccinate synthase ASS1 0.0009
2680 Argininosuccinate synthase argG 0.0009
3194 Argininosuccinate synthase argG 0.0009
76 Nitric-oxide synthase, brain NOS1 0.0009
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0008
6459 Glycodelin PAEP 0.0008
489 Monocarboxylate transporter 2 SLC16A7 0.0008
1867 Major prion protein PRNP 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
1025 Aquaporin-1 AQP1 0.0008
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0007
461 Glycine receptor subunit alpha-3 GLRA3 0.0007
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0007
2802 Endoglucanase G celCCG 0.0007
822 Aldose reductase AKR1B1 0.0007
6316 ADP-ribosylation factor 1 ARF1 0.0007
2112 Toll-like receptor 9 TLR9 0.0007
6228 Nuclear receptor coactivator 1 NCOA1 0.0007
6207 30S ribosomal protein S14 rpsN 0.0007
6209 30S ribosomal protein S19 rpsS 0.0007
6712 30S ribosomal protein S19 rpsS 0.0007
6726 30S ribosomal protein S19 rpsS 0.0007
6134 Sodium channel subunit beta-3 SCN3B 0.0007
6133 Sodium channel subunit beta-2 SCN2B 0.0007
6135 Sodium channel subunit beta-4 SCN4B 0.0007
6241 Nuclear receptor coactivator 2 NCOA2 0.0007
6132 Sodium channel subunit beta-1 SCN1B 0.0007
6129 Carbonic anhydrase-related protein 11 CA11 0.0007
6127 Carbonic anhydrase-related protein CA8 0.0007
6128 Carbonic anhydrase-related protein 10 CA10 0.0007
645 Penicillin-binding protein 1A mrcA 0.0007
5805 Penicillin-binding protein 1A ponA 0.0007
6185 Penicillin-binding protein 1A mrcA 0.0007
6799 Penicillin-binding protein 1A pbpA 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
1507 Cytochrome c CYCS 0.0007
125 DNA polymerase beta POLB 0.0007
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0007
2599 Tyrosine-protein kinase HCK HCK 0.0007
144 Hemoglobin subunit alpha HBA1 0.0006
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0006
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0006
6130 Carbonic anhydrase 13 CA13 0.0006
4954 Soluble cytochrome b558 Not Available 0.0006
4925 Cytochrome c-type protein SHP shp 0.0006
4916 Cyanoglobin glbN 0.0006
4915 Cytochrome c-550 psbV 0.0006
4959 Cytochrome c-550 psbV 0.0006
5216 Cytochrome c-550 psbV 0.0006
4947 Bacterial hemoglobin vhb 0.0006
4934 Cytochrome c-551 nirM 0.0006
5218 Cytochrome c-551 nirM 0.0006
4994 Hemoglobin-like protein HbO glbO 0.0006
4984 Neuroglobin NGB 0.0006
4943 Cytochrome c6 petJ 0.0006
4975 Cytochrome c-556 RPA3973 0.0006
4905 Cytochrome c2 Not Available 0.0006
4939 Cytochrome c2 cycA 0.0006
4964 Cytochrome c2 cycA 0.0006
4979 Cytochrome c2 cycA 0.0006
6673 Cytochrome c2 cycA 0.0006
4910 Cytoglobin CYGB 0.0006
4936 Cytochrome c2 iso-2 Not Available 0.0006
4998 Hemoglobin-like protein yjbI yjbI 0.0006
4981 Iron-starvation protein PigA pigA 0.0006
5000 HemO hemO 0.0006
4907 Cytochrome c-L moxG 0.0006
6865 Cytochrome c-L moxG 0.0006
4909 CooA protein cooA 0.0006
4935 Cytochrome c-554 cycA1 0.0006
4942 Diheme cytochrome c napB napB 0.0006
644 Heme oxygenase 2 HMOX2 0.0006
4982 Heme oxygenase 2 pbsA2 0.0006
4971 Nonaheme cytochrome c hmcA 0.0006
4904 Cytochrome c family protein GSU1996 0.0006
4961 Hemophore HasA hasA 0.0006
4976 Apocytochrome f petA 0.0006
6407 Apocytochrome f petA 0.0006
4764 Cytochrome P450 165C4 CYP165C4 0.0006
4972 P450cin cinA 0.0006
4931 Cytochrome P450 167A1 CYP167A1 0.0006
4960 Putative cytochrome P450-family protein SCO7417 0.0006
4903 Methyl-accepting chemotaxis protein Tar4 0.0006
4926 Heme-based aerotactic transducer hemAT hemAT 0.0006
4999 Cytochrome P450 165B3 CYP165B3 0.0006
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0006
4989 Cytochrome c551 peroxidase ccp 0.0006
5222 Cytochrome c551 peroxidase ccpA 0.0006
4937 Cytochrome oxidase subunit II rcoxA 0.0006
4922 Cytochrome c, putative SO_4144 0.0006
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0006
4993 Hydroxylamine oxidoreductase hao1 0.0006
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0006
3093 Catalase HPII katE 0.0006
4952 Catalase/peroxidase katA 0.0006
1291 cAMP response element-binding protein CREB1 0.0006
1569 G1/S-specific cyclin-D1 CCND1 0.0006
1525 Heparin-binding growth factor 2 FGF2 0.0006
5221 Cytochrome c3, 13 kDa Not Available 0.0006
3152 Cytochrome c'' cycA 0.0006
5220 Split-Soret cytochrome c Ddes_2150 0.0006
3700 Cytochrome c-552 precursor nrfA 0.0006
4210 Toll-like receptor 4 TLR4 0.0005
244 Angiotensin-converting enzyme ACE 0.0005
6211 Tubulin epsilon chain TUBE1 0.0005
6212 Tubulin gamma-1 chain TUBG1 0.0005
6210 Tubulin delta chain TUBD1 0.0005
3127 Nitrite reductase nirS 0.0005
3284 Nitrite reductase nirS 0.0005
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0005
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0004
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0004
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0004
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0004
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0004
4920 Peroxidase/catalase katG 0.0004
2119 Cytochrome b5 CYB5A 0.0004
4990 PpcA ppcA 0.0004
3405 Quinohaemoprotein ethanol dehydrogenase type-1 qheDH 0.0004
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0004
3375 Acidic cytochrome c3 Not Available 0.0004
4988 Sulfite oxidase, mitochondrial SUOX 0.0004
2915 Sensor protein fixL fixL 0.0004
4944 Sensor protein fixL fixL 0.0004
4385 Cytochrome c' Not Available 0.0004
4967 Cytochrome c' cycA 0.0004
5038 Cytochrome c' Not Available 0.0004
5223 Cytochrome c' cycP 0.0004
3570 Cytochrome P450 152A1 cypC 0.0004
4813 Heme oxygenase hmuO 0.0004
5769 Heme oxygenase Not Available 0.0004
4037 Hypothetical protein GPX1 0.0004
4297 Hypothetical protein SP_1951 0.0004
4521 Hypothetical protein BC_2969 0.0004
4540 Hypothetical protein TM_1070 0.0004
4555 Hypothetical protein MT1739 0.0004
4569 Hypothetical protein mshD 0.0004
4578 Hypothetical protein PA3270 0.0004
4747 Hypothetical protein PA3967 0.0004
5177 Hypothetical protein TM_0096 0.0004
5194 Hypothetical protein PA1204 0.0004
5240 Hypothetical protein Rv2991 0.0004
5370 Hypothetical protein TM_1158 0.0004
5710 Hypothetical protein Tb927.5.1360 0.0004
4289 Cytochrome P450 TT_P0059 0.0004
6262 Cytochrome P450 staP 0.0004
4992 Cytochrome c peroxidase Not Available 0.0004
2216 Fibroblast growth factor receptor 4 FGFR4 0.0004
1176 Mitogen-activated protein kinase 1 MAPK1 0.0004
3411 Cytochrome P450 121 cyp121 0.0004
3670 Soluble cytochrome b562 precursor cybC 0.0004
3291 Cytochrome c-552 cycA 0.0004
4927 Cytochrome c-552 nrfA 0.0004
4938 Cytochrome c-552 cycA 0.0004
4953 Cytochrome c-552 nrfA 0.0004
5217 Cytochrome c-552 cycM 0.0004
2617 Nitric oxide synthase oxygenase nos 0.0004
2701 Nitric oxide synthase oxygenase nos 0.0004
3102 Flavohemoprotein hmp 0.0004
4969 Flavohemoprotein hmp 0.0004
594 Thyroxine-binding globulin SERPINA7 0.0004
758 Thyroid hormone receptor alpha THRA 0.0003
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0003
2972 6-deoxyerythronolide B hydroxylase eryF 0.0003
2240 Cell division protein kinase 2 CDK2 0.0003
199 Monocarboxylate transporter 8 SLC16A2 0.0003
4608 Putative cytochrome P450 SCO1207 0.0003
4963 Putative cytochrome P450 SCO2884 0.0003
6254 Putative cytochrome P450 SCO6998 0.0003
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0003
346 Thyroid hormone receptor beta-1 THRB 0.0003
693 Hemoglobin subunit beta HBB 0.0003
6268 Hydroxyacid oxidase 1 HAO1 0.0003
810 Heme oxygenase 1 HMOX1 0.0003
3391 Heme oxygenase 1 pbsA1 0.0003
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