DT-Web

DB00818 - Propofol


Identification
Name Propofol
Accession Number DB00818 (APRD01201, DB05893, EXPT02558)
Type small molecule
Description Propofol is an intravenous anaesthetic agent used for induction and maintenance of general anaesthesia. IV administration of propfol is used to induce unconsciousness after which anaesthesia may be maintained using a combination of medications. Recovery from propofol-induced anaesthesia is generally rapid and associated with less frequent side effects (e.g. drowsiness, nausea, vomiting) than with thiopental, methohexital, and etomidate. Propofol may be used prior to diagnostic procedures requiring anaesthesia, in the management of refractory status epilepticus, and for induction and/or maintenance of anaesthesia prior to and during surgeries.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 178.2707
Groups approved
Monoisotopic Weight 178.135765198
Pharmacology
Indication Used for induction and/or maintenance of anaesthesia and for management of refractory status epilepticus.
Mechanism of action The action of propofol involves a positive modulation of the inhibitory function of the neurotransmitter gama-aminobutyric acid (GABA) through GABA-A receptors.
Absorption Rapid - time to onset of unconsciousness is 15-30 seconds, due to rapid distribution from plasma to the CNS. Distribution is so rapid that peak plasma concentrations cannot be readily measured. Duration of action is 5-10 minutes.
Protein binding 95 to 99%, primarily to serum albumin and hemoglobin
Biotransformation Hepatically metabolized mainly by glucuronidation at the C1-hydroxyl. Hydroxylation of the benzene ring to 4-hydroxypropofol may also occur via CYP2B6 and 2C9 with subsequent conjugation to sulfuric and/or glucuronic acid. Hydroxypropofol has approximately 1/3 of hypnotic activity of propofol.
Route of elimination It is chiefly eliminated by hepatic conjugation to inactive metabolites which are excreted by the kidney.
Toxicity Overdosage may increase pharmacologic and adverse effects or cause death.

IV LD50=53 mg/kg (mice), 42 mg/kg (rats). Oral LD50 (as a solution in soybean oil)=1230 mg/kg (mice), 600 mg/kg (rats)
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Tacrine The metabolism of Tacrine, a CYP1A2 substrate, may be reduced by Propofol, a CYP1A2 inhibitors. Monitor the efficacy and toxicity of Tacrine if Propofol is initiated, discontinued or if the dose is changed.
Tizanidine Propofol may decrease the metabolism and clearance of Tizanidine. Consider alternate therapy or use caution during co-administration.
Food Interactions Not Available

Targets


Gamma-aminobutyric-acid receptor subunit beta-2
Name Gamma-aminobutyric-acid receptor subunit beta-2
Gene Name GABRB2
Pharmacological action yes
Actions potentiator
References
  • Franks NP: Molecular targets underlying general anaesthesia. Br J Pharmacol. 2006 Jan;147 Suppl 1:S72-81. - Pubmed
DTHybrid score 0.257
Gamma-aminobutyric-acid receptor subunit beta-3
Name Gamma-aminobutyric-acid receptor subunit beta-3
Gene Name GABRB3
Pharmacological action yes
Actions potentiator
References
  • Franks NP: Molecular targets underlying general anaesthesia. Br J Pharmacol. 2006 Jan;147 Suppl 1:S72-81. - Pubmed
DTHybrid score 0.2822
Sodium channel protein type 4 subunit alpha
Name Sodium channel protein type 4 subunit alpha
Gene Name SCN4A
Pharmacological action unknown
Actions inhibitor
References
  • Haeseler G, Karst M, Foadi N, Gudehus S, Roeder A, Hecker H, Dengler R, Leuwer M: High-affinity blockade of voltage-operated skeletal muscle and neuronal sodium channels by halogenated propofol analogues. Br J Pharmacol. 2008 Sep;155(2):265-75. Epub 2008 Jun 23. - Pubmed
DTHybrid score 0.2323
Sodium channel protein type 2 subunit alpha
Name Sodium channel protein type 2 subunit alpha
Gene Name SCN2A
Pharmacological action unknown
Actions inhibitor
References
  • Haeseler G, Karst M, Foadi N, Gudehus S, Roeder A, Hecker H, Dengler R, Leuwer M: High-affinity blockade of voltage-operated skeletal muscle and neuronal sodium channels by halogenated propofol analogues. Br J Pharmacol. 2008 Sep;155(2):265-75. Epub 2008 Jun 23. - Pubmed
DTHybrid score 0.2561

Enzymes


Cytochrome P450 2C9
Name Cytochrome P450 2C9
Gene Name CYP2C9
Actions substrate,inhibitor
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.891
Cytochrome P450 2B6
Name Cytochrome P450 2B6
Gene Name CYP2B6
Actions substrate
References
  • Walsky RL, Astuccio AV, Obach RS: Evaluation of 227 drugs for in vitro inhibition of cytochrome P450 2B6. J Clin Pharmacol. 2006 Dec;46(12):1426-38. - Pubmed
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.5491
UDP-glucuronosyltransferase 1-8
Name UDP-glucuronosyltransferase 1-8
Gene Name UGT1A8
Actions substrate
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
DTHybrid score 0.2016
UDP-glucuronosyltransferase 1-9
Name UDP-glucuronosyltransferase 1-9
Gene Name UGT1A9
Actions substrate
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Takahashi H, Maruo Y, Mori A, Iwai M, Sato H, Takeuchi Y: Effect of D256N and Y483D on propofol glucuronidation by human uridine 5'-diphosphate glucuronosyltransferase (UGT1A9). Basic Clin Pharmacol Toxicol. 2008 Aug;103(2):131-6. - Pubmed
DTHybrid score 0.3652
UDP-glucuronosyltransferase 1-1
Name UDP-glucuronosyltransferase 1-1
Gene Name UGT1A1
Actions inhibitor
References
  • Mano Y, Usui T, Kamimura H: Substrate-dependent modulation of UDP-glucuronosyltransferase 1A1 (UGT1A1) by propofol in recombinant human UGT1A1 and human liver microsomes. Basic Clin Pharmacol Toxicol. 2007 Sep;101(3):211-4. - Pubmed
DTHybrid score 0.3277
Fatty-acid amide hydrolase
Name Fatty-acid amide hydrolase
Gene Name FAAH
Actions substrate
References
  • Zhu F, Han B, Kumar P, Liu X, Ma X, Wei X, Huang L, Guo Y, Han L, Zheng C, Chen Y: Update of TTD: Therapeutic Target Database. Nucleic Acids Res. 2010 Jan;38(Database issue):D787-91. Epub 2009 Nov 20. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.0734
Cytochrome P450 2E1
Name Cytochrome P450 2E1
Gene Name CYP2E1
Actions substrate,inhibitor
References
  • Chen TL, Ueng TH, Chen SH, Lee PH, Fan SZ, Liu CC: Human cytochrome P450 mono-oxygenase system is suppressed by propofol. Br J Anaesth. 1995 May;74(5):558-62. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.5117
Cytochrome P450 1B1
Name Cytochrome P450 1B1
Gene Name CYP1B1
Actions inhibitor
References
  • Chen TL, Ueng TH, Chen SH, Lee PH, Fan SZ, Liu CC: Human cytochrome P450 mono-oxygenase system is suppressed by propofol. Br J Anaesth. 1995 May;74(5):558-62. - Pubmed
DTHybrid score 0.2494
Cytochrome P450 1A1
Name Cytochrome P450 1A1
Gene Name CYP1A1
Actions inhibitor
References
  • Chen TL, Ueng TH, Chen SH, Lee PH, Fan SZ, Liu CC: Human cytochrome P450 mono-oxygenase system is suppressed by propofol. Br J Anaesth. 1995 May;74(5):558-62. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4562
Cytochrome P450 1A2
Name Cytochrome P450 1A2
Gene Name CYP1A2
Actions substrate,inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.7545
Cytochrome P450 2A6
Name Cytochrome P450 2A6
Gene Name CYP2A6
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.484
Cytochrome P450 2C18
Name Cytochrome P450 2C18
Gene Name CYP2C18
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3285
Cytochrome P450 2C19
Name Cytochrome P450 2C19
Gene Name CYP2C19
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.7466
Cytochrome P450 2C8
Name Cytochrome P450 2C8
Gene Name CYP2C8
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.6416
Cytochrome P450 2D6
Name Cytochrome P450 2D6
Gene Name CYP2D6
Actions substrate,inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.7895
Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate,inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 1.0746
UDP-glucuronosyltransferase 1-6
Name UDP-glucuronosyltransferase 1-6
Gene Name Not Available
Actions substrate
References
  • Gu J, Lu K, Xia P, Tang M, Dai Q, Ma D, Tao G: Pharmacokinetics of propofol and extrahepatic UGT1A6 gene expression in anhepatic rats. Pharmacology. 2009;84(4):219-26. Epub 2009 Sep 10. - Pubmed
DTHybrid score Not Available

Carriers


Predictions


Id Partner name Gene Name Score
1588 Multidrug resistance protein 1 ABCB1 0.5103
4118 Cytochrome P450 3A5 CYP3A5 0.385
6107 Cytochrome P450 3A7 CYP3A7 0.2744
20 Prostaglandin G/H synthase 1 PTGS1 0.2587
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.1924
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.1919
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.1739
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.1738
290 Prostaglandin G/H synthase 2 PTGS2 0.1632
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.156
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.1551
6245 SDS hydrolase SdsA1 sdsA1 0.1544
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.1536
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.1534
1729 Solute carrier family 22 member 6 SLC22A6 0.1476
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.1437
220 Sodium channel protein type 5 subunit alpha SCN5A 0.1432
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.1362
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.1362
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.1361
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.1361
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.136
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.136
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.1358
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.1355
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.1326
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.1313
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.1308
1181 Alpha-1-acid glycoprotein 1 ORM1 0.1178
862 Multidrug resistance-associated protein 1 ABCC1 0.1075
492 Histamine H1 receptor HRH1 0.1064
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.106
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.103
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.1014
824 Sodium-dependent serotonin transporter SLC6A4 0.0984
3811 Cytochrome P450 19A1 CYP19A1 0.0979
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0902
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0845
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0832
6145 Solute carrier family 22 member 1 SLC22A1 0.0783
502 5-hydroxytryptamine 2A receptor HTR2A 0.0766
468 Cytochrome P450 4A11 CYP4A11 0.073
776 Bile salt export pump ABCB11 0.0728
6142 Solute carrier family 22 member 8 SLC22A8 0.0725
831 D(2) dopamine receptor DRD2 0.0724
847 Mu-type opioid receptor OPRM1 0.0723
6144 Solute carrier family 22 member 2 SLC22A2 0.0705
2164 Multidrug resistance-associated protein 4 ABCC4 0.0701
467 Delta-type opioid receptor OPRD1 0.0673
556 Alpha-1A adrenergic receptor ADRA1A 0.066
696 Kappa-type opioid receptor OPRK1 0.0649
118 Organic cation/carnitine transporter 2 SLC22A5 0.0637
136 Estrogen receptor ESR1 0.0625
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0619
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0618
766 Beta-2 adrenergic receptor ADRB2 0.0611
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0604
3941 Amine oxidase [flavin-containing] A MAOA 0.0595
811 Translocator protein TSPO 0.0588
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0587
6102 Arylamine N-acetyltransferase 2 NAT2 0.0557
6143 Solute carrier family 22 member 7 SLC22A7 0.0549
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0543
891 Dihydropteroate synthase folP 0.0533
5359 Dihydropteroate synthase folP 0.0533
7175 Dihydropteroate synthase sulI 0.0533
373 Transthyretin TTR 0.0526
23 D(1A) dopamine receptor DRD1 0.0524
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0518
320 5-hydroxytryptamine 1A receptor HTR1A 0.0515
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0502
318 Alpha-2A adrenergic receptor ADRA2A 0.0502
6147 Solute carrier family 22 member 3 SLC22A3 0.0498
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0498
4604 Liver carboxylesterase 1 CES1 0.0493
590 5-hydroxytryptamine 2C receptor HTR2C 0.0491
341 5-hydroxytryptamine 3 receptor HTR3A 0.0489
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0488
713 Sodium-dependent dopamine transporter SLC6A3 0.0487
1024 Solute carrier family 22 member 11 SLC22A11 0.0475
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0467
3939 Amine oxidase [flavin-containing] B MAOB 0.0467
6031 Cytochrome P450 3A43 CYP3A43 0.0466
3810 Catechol O-methyltransferase COMT 0.0466
465 Calmodulin CALM1 0.0461
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0457
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0452
260 Cytochrome P450 51 ERG11 0.0447
761 Cytochrome P450 51 ERG11 0.0447
3163 Cytochrome P450 51 cyp51 0.0447
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0441
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0432
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0428
193 Beta-1 adrenergic receptor ADRB1 0.0424
146 Androgen receptor AR 0.0419
632 Alpha-1B adrenergic receptor ADRA1B 0.0415
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0408
817 DNA topoisomerase 2-alpha TOP2A 0.0405
274 Muscarinic acetylcholine receptor M5 CHRM5 0.04
6027 Alkaline phosphatase, tissue-nonspecific isozyme ALPL 0.0399
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0397
450 Muscarinic acetylcholine receptor M4 CHRM4 0.039
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0389
871 Glucocorticoid receptor NR3C1 0.0388
3947 Xanthine dehydrogenase/oxidase XDH 0.0384
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0384
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0379
731 HIV-1 protease HIV-1 protease 0.0373
482 Glycine receptor subunit alpha-1 GLRA1 0.0368
6014 Cytochrome P450 2A13 CYP2A13 0.0367
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0365
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.036
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0359
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0357
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0355
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0348
504 Mast/stem cell growth factor receptor KIT 0.0345
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0343
833 Organic cation/carnitine transporter 1 SLC22A4 0.0339
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0338
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0338
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0337
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0333
1757 Myeloperoxidase MPO 0.0328
36 Insulin receptor INSR 0.0325
844 Epidermal growth factor receptor EGFR 0.0323
275 Arachidonate 5-lipoxygenase ALOX5 0.0321
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.032
3923 Cholinesterase BCHE 0.0318
122 P2Y purinoceptor 12 P2RY12 0.0317
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0317
6148 Multidrug resistance-associated protein 7 ABCC10 0.0314
885 5-hydroxytryptamine 1B receptor HTR1B 0.031
638 D(3) dopamine receptor DRD3 0.0309
6135 Sodium channel subunit beta-4 SCN4B 0.0308
6133 Sodium channel subunit beta-2 SCN2B 0.0308
6134 Sodium channel subunit beta-3 SCN3B 0.0308
6132 Sodium channel subunit beta-1 SCN1B 0.0308
6127 Carbonic anhydrase-related protein CA8 0.0308
6129 Carbonic anhydrase-related protein 11 CA11 0.0308
6128 Carbonic anhydrase-related protein 10 CA10 0.0308
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0306
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0306
6220 Aryl hydrocarbon receptor AHR 0.0305
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0304
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0304
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0299
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0298
26 Vascular endothelial growth factor receptor 3 FLT4 0.0288
380 Cytochrome P450 17A1 CYP17A1 0.0283
921 Glutamate receptor 2 GRIA2 0.0283
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0279
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0278
2981 Phospholipase A2, membrane associated PLA2G2A 0.0277
738 Monocarboxylate transporter 1 SLC16A1 0.0277
295 Carbonic anhydrase 1 CA1 0.0276
32 Vascular endothelial growth factor receptor 1 FLT1 0.0276
6126 Carbonic anhydrase 7 CA7 0.0276
789 Alpha-1D adrenergic receptor ADRA1D 0.0275
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0273
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0272
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0271
6020 Aldehyde oxidase AOX1 0.0269
592 Carbonic anhydrase 4 CA4 0.0269
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0268
6026 Alcohol dehydrogenase 6 ADH6 0.0266
16 Adenosine A1 receptor ADORA1 0.0261
228 Beta platelet-derived growth factor receptor PDGFRB 0.0261
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.026
6131 Carbonic anhydrase 14 CA14 0.0259
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0259
407 Vascular endothelial growth factor receptor 2 KDR 0.0257
6141 Sodium/bile acid cotransporter SLC10A1 0.0254
777 Tumor necrosis factor TNF 0.0254
725 5-hydroxytryptamine 1D receptor HTR1D 0.025
6137 Multidrug resistance-associated protein 6 ABCC6 0.0249
6130 Carbonic anhydrase 13 CA13 0.0247
6122 Carbonic anhydrase 3 CA3 0.0246
537 ATP synthase delta chain, mitochondrial ATP5D 0.0245
629 Alpha-2B adrenergic receptor ADRA2B 0.0242
6136 Multidrug resistance-associated protein 5 ABCC5 0.0242
705 Glutamate receptor 1 GRIA1 0.0237
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0235
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0235
1178 Adenosine A2a receptor ADORA2A 0.0234
70 Type-1 angiotensin II receptor AGTR1 0.0233
756 Sex hormone-binding globulin SHBG 0.023
1010 Cytochrome P450 51A1 CYP51A1 0.0228
869 Estrogen receptor beta ESR2 0.0226
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0225
4205 Carbonic anhydrase 9 CA9 0.0217
3007 Carbonic anhydrase 12 CA12 0.0217
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0216
378 Alpha-2C adrenergic receptor ADRA2C 0.0216
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0216
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0214
6085 Fatty acid-binding protein, intestinal FABP2 0.0212
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0211
267 Plasminogen activator inhibitor 1 SERPINE1 0.021
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0209
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0209
6182 Cytochrome P450 2J2 CYP2J2 0.0208
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0206
357 Carbonic anhydrase 2 CA2 0.0204
1039 Histone deacetylase 9 HDAC9 0.0203
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0203
1192 Sulfotransferase 1A1 SULT1A1 0.0202
3809 Estrogen-related receptor gamma ESRRG 0.0202
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0201
432 D(4) dopamine receptor DRD4 0.0199
442 Envelope glycoprotein gp41 0.0198
4859 Envelope glycoprotein env 0.0198
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0197
4120 NADPH--cytochrome P450 reductase POR 0.0196
4228 Keratin, type II cytoskeletal 7 KRT7 0.0194
6221 Steroid hormone receptor ERR1 ESRRA 0.0191
4164 Potassium voltage-gated channel subfamily KQT member 5 KCNQ5 0.0191
4163 Potassium voltage-gated channel subfamily KQT member 4 KCNQ4 0.0191
3866 Serum amyloid A protein SAA1 0.019
1200 AMBP protein AMBP 0.019
1932 Apolipoprotein E APOE 0.019
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0189
436 5-hydroxytryptamine 2B receptor HTR2B 0.0185
3932 Glutathione S-transferase A2 GSTA2 0.0185
4203 Histamine N-methyltransferase HNMT 0.0184
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0184
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0183
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0183
4122 Histone deacetylase 2 HDAC2 0.0183
94 5-hydroxytryptamine 4 receptor HTR4 0.0182
477 DNA topoisomerase 4 subunit A parC 0.0182
886 DNA topoisomerase 4 subunit A parC 0.0182
6226 DNA topoisomerase 4 subunit A parC 0.0182
404 DNA gyrase subunit A gyrA 0.0179
6224 DNA gyrase subunit A gyrA 0.0179
613 Atrial natriuretic peptide receptor A NPR1 0.0179
5880 Thrombopoietin receptor MPL 0.0178
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0177
273 Apoptosis regulator Bcl-2 BCL2 0.0175
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0175
614 Progesterone receptor PGR 0.0174
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0174
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0172
1050 Bile salt sulfotransferase SULT2A1 0.0171
716 5-hydroxytryptamine 7 receptor HTR7 0.017
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.017
1389 Transforming growth factor beta-1 TGFB1 0.0169
571 Melatonin receptor type 1A MTNR1A 0.0169
362 Melatonin receptor type 1B MTNR1B 0.0169
29 Tubulin beta-1 chain TUBB1 0.0164
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0162
84 Nuclear receptor 0B1 NR0B1 0.0162
319 Opioid receptor, sigma 1 OPRS1 0.0159
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0158
85 Growth hormone receptor GHR 0.0156
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0153
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0152
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.015
823 Fibroblast growth factor receptor 2 FGFR2 0.0149
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0148
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0147
1275 Estrogen sulfotransferase SULT1E1 0.0146
6541 Peptostreptococcal albumin-binding protein pab 0.0142
124 Histamine H2 receptor HRH2 0.0142
183 Vascular endothelial growth factor A VEGFA 0.0142
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0141
6043 Putative G-protein coupled receptor 44 GPR44 0.0141
1517 Beta-3 adrenergic receptor ADRB3 0.0141
6174 50S ribosomal protein L32 rpmF 0.0139
1656 CYP2B protein CYP2B 0.0139
251 Alcohol dehydrogenase 1A ADH1A 0.0136
6103 Arylamine N-acetyltransferase 1 NAT1 0.0135
365 Dihydrofolate reductase DHFR 0.0135
2381 Dihydrofolate reductase DFR1 0.0135
2833 Dihydrofolate reductase Not Available 0.0135
2931 Dihydrofolate reductase folA 0.0135
3544 Dihydrofolate reductase folA 0.0135
3682 Dihydrofolate reductase folA 0.0135
6642 Dihydrofolate reductase folA 0.0135
6756 Dihydrofolate reductase dfrA 0.0135
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0135
1618 High affinity nerve growth factor receptor NTRK1 0.0134
818 50S ribosomal protein L10 rplJ 0.0134
6432 Transporter snf 0.0134
1629 Transcription factor AP-1 JUN 0.0133
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0132
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0132
88 Retinoic acid receptor RXR-beta RXRB 0.0131
4116 Dihydropteroate synthetase Not Available 0.0131
3426 Glutamine synthetase glnA 0.0131
3987 Glutamine synthetase GLUL 0.0131
518 Peroxidase/catalase T katG 0.013
790 DNA polymerase subunit alpha B POLA2 0.0129
444 Alcohol dehydrogenase 1B ADH1B 0.0128
904 Glutathione S-transferase P GSTP1 0.0128
174 Sigma 1-type opioid receptor SIGMAR1 0.0127
814 Ryanodine receptor 1 RYR1 0.0127
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0126
936 Ephrin type-A receptor 2 EPHA2 0.0126
161 Tubulin beta chain TUBB 0.0125
312 Tubulin beta chain TUB2 0.0125
232 Corticosteroid-binding globulin SERPINA6 0.0125
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0125
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0124
2230 Catalase CAT 0.0122
3249 Catalase katA 0.0122
3625 Catalase katA 0.0122
4539 Catalase katA 0.0122
4941 Catalase katB 0.0122
461 Glycine receptor subunit alpha-3 GLRA3 0.0122
6146 High affinity copper uptake protein 1 SLC31A1 0.0122
605 Fumarate reductase flavoprotein subunit frdA 0.0121
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0121
3673 Fumarate reductase flavoprotein subunit fccA 0.0121
4912 Fumarate reductase flavoprotein subunit ifcA 0.0121
6549 Fumarate reductase flavoprotein subunit frdA 0.0121
163 D(1B) dopamine receptor DRD5 0.0121
780 Retinoic acid receptor RXR-gamma RXRG 0.0121
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0121
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.012
528 5-hydroxytryptamine 1E receptor HTR1E 0.0119
2183 Fatty acid-binding protein, adipocyte FABP4 0.0119
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0119
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0119
459 Retinoic acid receptor RXR-alpha RXRA 0.0119
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0118
1714 Mitogen-activated protein kinase 3 MAPK3 0.0118
5934 Cytochrome P450 26A1 CYP26A1 0.0117
1256 5-hydroxytryptamine 6 receptor HTR6 0.0117
48 Pyridoxal kinase PDXK 0.0116
563 Thyroid peroxidase TPO 0.0116
54 Prothrombin F2 0.0114
474 Acetylcholinesterase ACHE 0.0113
2449 Tubulin alpha-3 chain TUBA1A 0.0113
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.0113
2499 Tubulin beta-2C chain TUBB2C 0.0113
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0112
68 Cannabinoid receptor 1 CNR1 0.0112
427 Substance-P receptor TACR1 0.0111
952 Dipeptidyl peptidase 4 DPP4 0.011
131 Synaptic vesicular amine transporter SLC18A2 0.0109
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0109
908 Glutathione S-transferase theta-1 GSTT1 0.0109
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0108
5787 Angiopoietin-1 receptor TEK 0.0108
2211 Fatty acid-binding protein, heart FABP3 0.0108
723 Cytosolic phospholipase A2 PLA2G4A 0.0107
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0107
737 Mineralocorticoid receptor NR3C2 0.0107
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0106
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0106
162 Retinoic acid receptor gamma-1 RARG 0.0105
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0105
517 Alcohol dehydrogenase 1C ADH1C 0.0105
4132 Chloride channel protein ClC-Ka CLCNKA 0.0104
7 Nitric oxide synthase, inducible NOS2 0.0103
284 DNA-directed RNA polymerase beta chain rpoB 0.0102
5773 DNA-directed RNA polymerase beta chain rpoB 0.0102
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0102
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0101
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0101
3808 Dihydropteroate synthase 2 folP2 0.0101
3601 Dihydropteroate synthase 1 folP1 0.0101
3807 Dihydropteroate synthase 1 folP1 0.0101
4237 50S ribosomal protein L22 rplV 0.01
4192 DNA topoisomerase 2-beta TOP2B 0.0099
2112 Toll-like receptor 9 TLR9 0.0097
958 Insulin-like growth factor 1 receptor IGF1R 0.0097
49 Endothelin B receptor EDNRB 0.0096
165 FL cytokine receptor FLT3 0.0096
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0095
558 Solute carrier family 12 member 1 SLC12A1 0.0094
566 Serotransferrin TF 0.0094
719 Retinoic acid receptor responder protein 1 RARRES1 0.0094
770 Retinoic acid-induced protein 3 GPRC5A 0.0094
820 Glycine receptor subunit alpha-2 GLRA2 0.0094
569 Retinal dehydrogenase 2 ALDH1A2 0.0094
5798 Mitogen-activated protein kinase 11 MAPK11 0.0093
4311 tRNA TRDMT1 0.0093
4325 tRNA trmD 0.0093
4328 tRNA trmD 0.0093
1852 Microtubule-associated protein 2 MAP2 0.0093
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0092
2021 Thrombomodulin THBD 0.0091
775 Acetyl-CoA carboxylase 2 ACACB 0.0091
1353 DNA topoisomerase 1 TOP1 0.0091
3552 DNA topoisomerase 1 topA 0.0091
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.009
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.009
578 Endothelin-1 receptor EDNRA 0.009
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.009
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.009
469 Annexin A1 ANXA1 0.009
5923 Microtubule-associated protein tau MAPT 0.009
5924 Microtubule-associated protein 4 MAP4 0.009
1992 Vitamin D-binding protein GC 0.0089
6766 O-GlcNAcase BT_4395 BT_4395 0.0089
2236 Casein kinase II subunit alpha CSNK2A1 0.0089
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0088
4238 50S ribosomal protein L4 rplD 0.0088
5578 50S ribosomal protein L4 rplD 0.0088
6173 50S ribosomal protein L4 rplD 0.0088
6219 50S ribosomal protein L4 rplD 0.0088
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0088
268 Adenosine A2b receptor ADORA2B 0.0088
106 Cannabinoid receptor 2 CNR2 0.0088
611 Retinal dehydrogenase 1 ALDH1A1 0.0088
3830 Calreticulin CALR 0.0088
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0087
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0087
6044 Serum paraoxonase/lactonase 3 PON3 0.0086
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0085
1569 G1/S-specific cyclin-D1 CCND1 0.0085
489 Monocarboxylate transporter 2 SLC16A7 0.0085
1630 Integrin beta-2 ITGB2 0.0085
581 Cytochrome P450 2R1 CYP2R1 0.0085
3917 Methylenetetrahydrofolate reductase MTHFR 0.0085
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0084
856 Vitamin D3 receptor VDR 0.0084
33 Cystine/glutamate transporter SLC7A11 0.0083
3856 Fibroblast growth factor receptor 3 FGFR3 0.0082
24 Thymidylate synthase TMP1 0.0082
359 Thymidylate synthase TYMS 0.0082
2626 Thymidylate synthase thyA 0.0082
2729 Thymidylate synthase thyA 0.0082
5352 Thymidylate synthase THYA 0.0082
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0082
6034 Hydroxyindole O-methyltransferase ASMT 0.0081
6035 Nuclear receptor ROR-beta RORB 0.0081
6036 Eosinophil peroxidase EPX 0.0081
117 Sterol O-acyltransferase 1 SOAT1 0.0081
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0081
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0081
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0081
565 Extracellular calcium-sensing receptor CASR 0.008
6525 Group IID secretory phospholipase A2 PLA2G2D 0.008
634 Squalene monooxygenase SQLE 0.0079
7196 Squalene monooxygenase ERG1 0.0079
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0079
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0079
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0079
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0079
511 5-hydroxytryptamine 1F receptor HTR1F 0.0079
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0079
173 Toll-like receptor 7 TLR7 0.0079
645 Penicillin-binding protein 1A mrcA 0.0078
5805 Penicillin-binding protein 1A ponA 0.0078
6185 Penicillin-binding protein 1A mrcA 0.0078
6799 Penicillin-binding protein 1A pbpA 0.0078
2178 Metabotropic glutamate receptor 5 GRM5 0.0078
6138 Multidrug resistance protein 3 ABCB4 0.0077
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0077
1176 Mitogen-activated protein kinase 1 MAPK1 0.0077
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0076
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0076
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0076
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0076
3957 Adenosine deaminase ADA 0.0076
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0075
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0075
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0075
1541 Metalloproteinase mmp20 0.0074
164 Histamine H4 receptor HRH4 0.0074
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0074
976 Platelet glycoprotein IX GP9 0.0073
4148 Serine/threonine-protein kinase mTOR MTOR 0.0073
153 Dopamine beta-hydroxylase DBH 0.0073
543 Penicillin-binding protein 1B mrcB 0.0072
6186 Penicillin-binding protein 1B ponB 0.0072
6822 Penicillin-binding protein 1b pbp1b 0.0072
6844 Penicillin-binding protein 1b pbp1b 0.0072
1360 Sphingomyelin phosphodiesterase SMPD1 0.0072
1 Peptidoglycan synthetase ftsI ftsI 0.0071
4155 Peptidoglycan synthetase ftsI ftsI 0.0071
765 Indoleamine 2,3-dioxygenase IDO1 0.0071
81 Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial MCCC2 0.007
547 Propionyl-CoA carboxylase alpha chain, mitochondrial PCCA 0.007
495 Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial MCCC1 0.007
177 Biotin--protein ligase HLCS 0.007
690 Acetyl-CoA carboxylase 1 ACACA 0.007
6163 Copper-transporting ATPase 2 ATP7B 0.007
6165 Copper-transporting ATPase 1 ATP7A 0.007
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0069
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0069
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0069
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0069
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0069
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0069
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0069
2853 14 kDa fatty acid-binding protein Not Available 0.0068
239 Coagulation factor X F10 0.0068
1063 Signal transducer and activator of transcription 5B STAT5B 0.0067
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0067
105 Sodium-dependent multivitamin transporter SLC5A6 0.0067
1636 Trace amine-associated receptor 1 TAAR1 0.0067
2298 Cytochrome P450-cam camC 0.0066
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0066
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0066
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0066
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0065
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0064
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0064
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0064
1820 Beta-nerve growth factor NGF 0.0064
896 Glutathione S-transferase Mu 1 GSTM1 0.0063
6500 Phospholipase A2 PLA2G1B 0.0063
1792 Tissue-type plasminogen activator PLAT 0.0063
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0063
1648 Elastin ELN 0.0063
65 Matrix metalloproteinase-9 Not Available 0.0063
1119 Peroxiredoxin-5, mitochondrial PRDX5 0.0063
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0063
133 Dihydropterate synthase sulI 0.0063
6042 Prostaglandin reductase 2 PTGR2 0.0063
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0062
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0062
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0062
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0061
734 D1 dopamine receptor-interacting protein calcyon CALY 0.006
601 Propionyl-CoA carboxylase beta chain, mitochondrial PCCB 0.006
890 Niemann-Pick C1-like protein 1 NPC1L1 0.006
633 Penicillin-binding proteins 1A/1B pbpA 0.0059
4103 Proteasome subunit beta type 2 PSMB2 0.0059
4102 Proteasome subunit beta type 5 PSMB5 0.0059
4101 Proteasome subunit beta type 1 PSMB1 0.0059
4217 Telomerase reverse transcriptase TERT 0.0059
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0058
208 DNA-directed RNA polymerase beta' chain rpoC 0.0058
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0058
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0057
400 Coagulation factor IX F9 0.0057
5461 Coagulation factor IX F9 0.0057
2539 Tubulin alpha-1 chain TUBA4A 0.0057
1483 Membrane copper amine oxidase AOC3 0.0057
771 Pyruvate carboxylase, mitochondrial PC 0.0056
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0055
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0055
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0055
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0055
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0055
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0055
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0055
6506 Stathmin-4 STMN4 0.0055
5300 Antigen peptide transporter 1 TAP1 0.0055
4226 Uridine phosphorylase 2 UPP2 0.0055
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0055
1374 Natriuretic peptides B NPPB 0.0054
572 Integrin alpha-L ITGAL 0.0054
1827 Gap junction alpha-1 protein GJA1 0.0054
1908 Vascular cell adhesion protein 1 VCAM1 0.0054
484 Tyrosine-protein kinase ABL2 ABL2 0.0054
291 Nitric-oxide synthase, endothelial NOS3 0.0054
2207 Rhodopsin RHO 0.0053
390 Adenosine A3 receptor ADORA3 0.0053
1760 Aminopeptidase N ANPEP 0.0053
6843 Aminopeptidase N pepN 0.0053
5998 Toll-like receptor 8 TLR8 0.0053
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0053
594 Thyroxine-binding globulin SERPINA7 0.0053
1268 Neuropeptide S receptor NPSR1 0.0053
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0053
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0053
3639 Thymidine phosphorylase deoA 0.0053
3936 Thymidine phosphorylase TYMP 0.0053
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0052
604 Vitamin K-dependent protein Z PROZ 0.0052
6339 Ig kappa chain V-II region RPMI 6410 Not Available 0.0052
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0052
712 Tubulin alpha chain TUB1 0.0052
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0052
3090 Chitosanase csn 0.0052
4149 Nuclear factor NF-kappa-B p100 subunit NFKB2 0.0052
4752 Peroxisomal trans-2-enoyl-CoA reductase PECR 0.0052
2751 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0052
4755 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0052
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0051
3823 Cytokine receptor common gamma chain IL2RG 0.0051
4692 A/G-specific adenine glycosylase mutY 0.0051
6149 Solute carrier family 22 member 10 SLC22A10 0.0051
751 Potassium channel subfamily K member 6 KCNK6 0.0051
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0051
4225 Uridine phosphorylase 1 UPP1 0.005
229 Retinoic acid receptor beta RARB 0.005
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.005
730 Retinoic acid receptor alpha RARA 0.0049
3404 Exotoxin A eta 0.0049
758 Thyroid hormone receptor alpha THRA 0.0049
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0048
6184 D-alanyl-D-alanine carboxypeptidase dacC dacC 0.0048
1313 Lactoylglutathione lyase GLO1 0.0048
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0048
422 Vitamin K-dependent protein C PROC 0.0048
1245 Vitamin K-dependent protein S PROS1 0.0048
6288 Low molecular weight phosphotyrosine protein phosphatase ACP1 0.0048
6073 Potassium channel subfamily K member 9 KCNK9 0.0047
6072 Potassium channel subfamily K member 3 KCNK3 0.0047
413 Amidophosphoribosyltransferase PPAT 0.0047
2515 Amidophosphoribosyltransferase purF 0.0047
3714 Amidophosphoribosyltransferase purF 0.0047
6832 Serine/threonine-protein kinase SRPK2 SRPK2 0.0046
172 Potassium channel subfamily K member 1 KCNK1 0.0046
1253 Interferon gamma IFNG 0.0046
2320 Thymidine kinase, cytosolic TK1 0.0046
3382 Glycolipid transfer protein GLTP 0.0046
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0046
992 Protein tyrosine kinase 2 beta PTK2B 0.0045
527 Prostacyclin receptor PTGIR 0.0045
3086 Plasmepsin-2 Not Available 0.0045
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0045
768 FK506-binding protein 1A FKBP1A 0.0045
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0045
724 Interleukin-2 receptor alpha chain IL2RA 0.0045
717 Interleukin-2 receptor subunit beta IL2RB 0.0045
115 Penicillin-binding protein 2 mrdA 0.0044
6069 Penicillin-binding protein 2 mrdA 0.0044
6118 Penicillin-binding protein 2 penA 0.0044
6187 Penicillin-binding protein 2 pbpA 0.0044
6686 Penicillin-binding protein 2 pbp2 0.0044
6939 Penicillin-binding protein 2 mrdA 0.0044
7163 Penicillin-binding protein 2 pbpA 0.0044
760 Fibroblast growth factor 1 FGF1 0.0044
1196 Complement decay-accelerating factor CD55 0.0044
130 Prostacyclin synthase PTGIS 0.0044
1262 Corticotropin-lipotropin POMC 0.0044
346 Thyroid hormone receptor beta-1 THRB 0.0044
5645 DNA topoisomerase 4 subunit B parE 0.0044
6227 DNA topoisomerase 4 subunit B parE 0.0044
887 DNA gyrase subunit B gyrB 0.0044
4150 DNA gyrase subunit B gyrB 0.0044
6225 DNA gyrase subunit B gyrB 0.0044
6033 High affinity interleukin-8 receptor A CXCR1 0.0044
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0043
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0043
473 L-lactate dehydrogenase A chain LDHA 0.0042
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0042
714 Glutathione reductase, mitochondrial GSR 0.0042
4606 Purine trans deoxyribosylase ptd 0.0042
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0041
6677 Myelin P2 protein PMP2 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
3679 MTA/SAH nucleosidase mtnN 0.004
1958 S-methyl-5-thioadenosine phosphorylase MTAP 0.004
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.004
6508 Putative uncharacterized protein srtB 0.004
6543 Putative uncharacterized protein tcp14 0.004
6615 Putative uncharacterized protein MT0785 0.004
6623 Putative uncharacterized protein Not Available 0.004
6806 Putative uncharacterized protein AGR_C_2535 0.004
6813 Putative uncharacterized protein SAV4671 0.004
6815 Putative uncharacterized protein AFE_1514 0.004
6819 Putative uncharacterized protein RUMGNA_03254 0.004
6825 Putative uncharacterized protein CV_3270 0.004
3913 Glutamic acid decarboxylase GAD65 0.004
4161 Furin FURIN 0.004
4210 Toll-like receptor 4 TLR4 0.0039
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0039
2290 ADP-ribosyl cyclase 2 BST1 0.0039
798 Osteocalcin BGLAP 0.0039
4146 Phosphatidylinositol 3-kinase regulatory subunit gamma PIK3R3 0.0039
4145 Phosphatidylinositol 3-kinase regulatory subunit beta PIK3R2 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
128 Adenine phosphoribosyltransferase APRT 0.0038
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0038
6067 Penicillin binding protein 2a mecA 0.0038
2808 Chloramphenicol acetyltransferase 3 cat3 0.0038
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0038
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0038
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0036
1291 cAMP response element-binding protein CREB1 0.0036
199 Monocarboxylate transporter 8 SLC16A2 0.0036
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0036
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0036
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0036
819 Penicillin-binding protein 4 dacB 0.0036
6168 Solute carrier family 22 member 16 SLC22A16 0.0035
822 Aldose reductase AKR1B1 0.0035
185 Vasopressin V1a receptor AVPR1A 0.0035
369 Coagulation factor VII F7 0.0035
2417 Chloramphenicol acetyltransferase cat 0.0035
3278 Chloramphenicol acetyltransferase cat 0.0035
2810 Dr hemagglutinin structural subunit draA 0.0035
939 50S ribosomal protein L3 rplC 0.0035
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0035
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0034
322 Vasopressin V2 receptor AVPR2 0.0034
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0034
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0034
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0034
1864 RET proto-oncogene RET 0.0034
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0033
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0033
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0033
735 Alanine aminotransferase 1 GPT 0.0033
3904 Alanine aminotransferase 2 GPT2 0.0033
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0033
1281 Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 0.0033
358 Cystathionine beta-synthase CBS 0.0033
233 Potassium channel subfamily K member 2 KCNK2 0.0033
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0032
331 Retinol-binding protein I, cellular RBP1 0.0032
707 72 kDa type IV collagenase MMP2 0.0032
1867 Major prion protein PRNP 0.0032
595 Fibrinogen alpha chain FGA 0.0032
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
1227 Cytochrome b MT-CYB 0.0031
6386 Cytochrome b petB 0.0031
6937 Cytochrome b MT-CYB 0.0031
674 Dihydroorotate dehydrogenase homolog, mitochondrial PFF0160c 0.0031
3760 Penicillin-binding protein 5 precursor dacA 0.0031
2264 Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase cobT 0.0031
76 Nitric-oxide synthase, brain NOS1 0.003
6459 Glycodelin PAEP 0.003
2578 Tubulin beta-3 chain TUBB3 0.003
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.003
3813 Fibrinogen gamma chain FGG 0.0029
3812 Fibrinogen beta chain [Contains: Fibrinopeptide B] FGB 0.0029
244 Angiotensin-converting enzyme ACE 0.0029
512 DNA-directed RNA polymerase alpha chain rpoA 0.0029
5772 DNA-directed RNA polymerase alpha chain rpoA 0.0029
330 Spermidine synthase SRM 0.0028
3038 Spermidine synthase speE 0.0028
6207 30S ribosomal protein S14 rpsN 0.0028
6209 30S ribosomal protein S19 rpsS 0.0028
6712 30S ribosomal protein S19 rpsS 0.0028
6726 30S ribosomal protein S19 rpsS 0.0028
1525 Heparin-binding growth factor 2 FGF2 0.0028
5431 Lipid binding protein Not Available 0.0028
3616 Fatty acid-binding protein, epidermal FABP5 0.0028
5433 UPF0230 protein TM_1468 TM_1468 0.0028
6218 Pannexin-1 PANX1 0.0028
1278 Pro-epidermal growth factor EGF 0.0028
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0028
1144 Hepatocyte growth factor receptor MET 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
2159 Quinone oxidoreductase CRYZ 0.0027
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0027
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0027
3849 Insulin-like growth factor-binding protein 7 IGFBP7 0.0027
2009 Protein NOV homolog NOV 0.0027
3847 Neuroendocrine convertase 2 PCSK2 0.0027
1949 Carboxypeptidase E CPE 0.0027
3850 Synaptotagmin-like protein 4 SYTL4 0.0027
3848 Neuroendocrine convertase 1 PCSK1 0.0027
3846 Retinoblastoma-associated protein RB1 0.0027
889 3-oxoacyl-[acyl-carrier-protein] synthase 1 fabB 0.0027
6860 3-oxoacyl-[acyl-carrier-protein] synthase 1 kasA 0.0027
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0026
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0026
4252 Penicillin-binding protein 5 dacA 0.0025
3221 Cytochrome c4 cc4 0.0025
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0025
334 S-adenosylmethionine synthetase isoform type-2 MAT2A 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
2300 Lysozyme E 0.0024
3633 Lysozyme R 0.0024
5597 Lysozyme 17 0.0024
159 Penicillin-binding protein 2B penA 0.0024
6121 Penicillin-binding protein 2B penA 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
6231 Pepsin A PGA3 0.0024
6070 Nischarin NISCH 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
4773 Deoxycytidine kinase DCK 0.0024
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0023
6048 Troponin C, skeletal muscle TNNC2 0.0023
283 SEC14-like protein 2 SEC14L2 0.0023
332 Beta-lactamase blaZ 0.0023
2478 Beta-lactamase ampC 0.0023
2613 Beta-lactamase ampC 0.0023
2635 Beta-lactamase ampC 0.0023
2700 Beta-lactamase penP 0.0023
5445 Beta-lactamase blaB 0.0023
6019 Beta-lactamase SHV-7 0.0023
6701 Beta-lactamase cphA 0.0023
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0023
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0023
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0023
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0023
1830 5'-nucleotidase NT5E 0.0023
6151 Monocarboxylate transporter 10 SLC16A10 0.0023
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.0023
293 Gamma-glutamyl hydrolase GGH 0.0023
1341 Histamine H3 receptor HRH3 0.0023
113 S-adenosylmethionine decarboxylase proenzyme AMD1 0.0022
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0022
411 Glycine N-methyltransferase GNMT 0.0022
2155 Insulin-degrading enzyme IDE 0.0022
2232 Interleukin-5 IL5 0.0022
6824 Tyrosine-protein kinase Lyn LYN 0.0021
997 Protein kinase C beta type PRKCB 0.0021
298 Renin REN 0.0021
1593 Mucin-2 MUC2 0.0021
2091 Endoplasmin HSP90B1 0.0021
4948 Cytochrome c-553 Not Available 0.0021
4923 Cytochrome c3 DvMF_2499 0.0021
4945 Cytochrome c3 Not Available 0.0021
4949 Cytochrome c3 DVU_3171 0.0021
4968 Cytochrome c3 cytc3 0.0021
4997 Cytochrome c3 SO_2727 0.0021
5219 Cytochrome c3 cyd 0.0021
4902 Nine-heme cytochrome c Ddes_2038 0.0021
3189 High-molecular-weight cytochrome c hmcA 0.0021
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.0021
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0021
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0021
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0021
63 Malate dehydrogenase mdh 0.0021
2329 Malate dehydrogenase mdh 0.0021
3445 Malate dehydrogenase mdh 0.0021
4420 Malate dehydrogenase mdh 0.0021
4438 Malate dehydrogenase mdh 0.0021
4954 Soluble cytochrome b558 Not Available 0.0021
4925 Cytochrome c-type protein SHP shp 0.0021
4934 Cytochrome c-551 nirM 0.0021
5218 Cytochrome c-551 nirM 0.0021
4943 Cytochrome c6 petJ 0.0021
4947 Bacterial hemoglobin vhb 0.0021
4905 Cytochrome c2 Not Available 0.0021
4939 Cytochrome c2 cycA 0.0021
4964 Cytochrome c2 cycA 0.0021
4979 Cytochrome c2 cycA 0.0021
6673 Cytochrome c2 cycA 0.0021
4915 Cytochrome c-550 psbV 0.0021
4959 Cytochrome c-550 psbV 0.0021
5216 Cytochrome c-550 psbV 0.0021
4916 Cyanoglobin glbN 0.0021
4975 Cytochrome c-556 RPA3973 0.0021
4984 Neuroglobin NGB 0.0021
4998 Hemoglobin-like protein yjbI yjbI 0.0021
4994 Hemoglobin-like protein HbO glbO 0.0021
4936 Cytochrome c2 iso-2 Not Available 0.0021
4909 CooA protein cooA 0.0021
4942 Diheme cytochrome c napB napB 0.0021
4907 Cytochrome c-L moxG 0.0021
6865 Cytochrome c-L moxG 0.0021
5000 HemO hemO 0.0021
4981 Iron-starvation protein PigA pigA 0.0021
644 Heme oxygenase 2 HMOX2 0.0021
4982 Heme oxygenase 2 pbsA2 0.0021
4935 Cytochrome c-554 cycA1 0.0021
4910 Cytoglobin CYGB 0.0021
4961 Hemophore HasA hasA 0.0021
4971 Nonaheme cytochrome c hmcA 0.0021
4904 Cytochrome c family protein GSU1996 0.0021
4976 Apocytochrome f petA 0.0021
6407 Apocytochrome f petA 0.0021
4989 Cytochrome c551 peroxidase ccp 0.0021
5222 Cytochrome c551 peroxidase ccpA 0.0021
4931 Cytochrome P450 167A1 CYP167A1 0.0021
4999 Cytochrome P450 165B3 CYP165B3 0.0021
4764 Cytochrome P450 165C4 CYP165C4 0.0021
4960 Putative cytochrome P450-family protein SCO7417 0.0021
4937 Cytochrome oxidase subunit II rcoxA 0.0021
4926 Heme-based aerotactic transducer hemAT hemAT 0.0021
4903 Methyl-accepting chemotaxis protein Tar4 0.0021
4972 P450cin cinA 0.0021
4993 Hydroxylamine oxidoreductase hao1 0.0021
4922 Cytochrome c, putative SO_4144 0.0021
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0021
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0021
3093 Catalase HPII katE 0.0021
4952 Catalase/peroxidase katA 0.0021
828 Phenylalanine-4-hydroxylase PAH 0.0021
3109 Phenylalanine-4-hydroxylase phhA 0.0021
1650 Heme carrier protein 1 SLC46A1 0.002
3611 Cytidine deaminase cdd 0.002
3707 Cytidine deaminase cdd 0.002
4211 Cytidine deaminase CDA 0.002
6501 Fatty acid-binding protein, liver FABP1 0.002
1970 Protein kinase C alpha type PRKCA 0.002
2216 Fibroblast growth factor receptor 4 FGFR4 0.0019
2408 Tyrosine-protein kinase SYK SYK 0.0019
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0019
718 Folate receptor gamma FOLR3 0.0019
299 Folate receptor beta FOLR2 0.0019
804 Mitochondrial folate transporter/carrier SLC25A32 0.0019
893 [Citrate [pro-3S]-lyase] ligase citC 0.0018
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0018
4386 Hemoglobin-like protein HbN glbN 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
327 Glutathione reductase gor 0.0018
5110 Glutathione reductase GR2 0.0018
3312 Fatty acid-binding protein, brain FABP7 0.0018
683 Potassium transporter GK0582 0.0018
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0018
1198 Serum paraoxonase/arylesterase 1 PON1 0.0018
6223 Penicillin-binding protein 1C pbpC 0.0018
1123 Eosinophil cationic protein RNASE3 0.0018
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
144 Hemoglobin subunit alpha HBA1 0.0016
1243 Cathepsin D CTSD 0.0016
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0015
3233 Bile acid receptor NR1H4 0.0015
4920 Peroxidase/catalase katG 0.0015
2119 Cytochrome b5 CYB5A 0.0015
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0015
4990 PpcA ppcA 0.0015
3375 Acidic cytochrome c3 Not Available 0.0015
4988 Sulfite oxidase, mitochondrial SUOX 0.0015
4385 Cytochrome c' Not Available 0.0015
4967 Cytochrome c' cycA 0.0015
5038 Cytochrome c' Not Available 0.0015
5223 Cytochrome c' cycP 0.0015
2915 Sensor protein fixL fixL 0.0015
4944 Sensor protein fixL fixL 0.0015
4037 Hypothetical protein GPX1 0.0015
4297 Hypothetical protein SP_1951 0.0015
4521 Hypothetical protein BC_2969 0.0015
4540 Hypothetical protein TM_1070 0.0015
4555 Hypothetical protein MT1739 0.0015
4569 Hypothetical protein mshD 0.0015
4578 Hypothetical protein PA3270 0.0015
4747 Hypothetical protein PA3967 0.0015
5177 Hypothetical protein TM_0096 0.0015
5194 Hypothetical protein PA1204 0.0015
5240 Hypothetical protein Rv2991 0.0015
5370 Hypothetical protein TM_1158 0.0015
5710 Hypothetical protein Tb927.5.1360 0.0015
3570 Cytochrome P450 152A1 cypC 0.0015
4992 Cytochrome c peroxidase Not Available 0.0015
4813 Heme oxygenase hmuO 0.0015
5769 Heme oxygenase Not Available 0.0015
4289 Cytochrome P450 TT_P0059 0.0015
6262 Cytochrome P450 staP 0.0015
3844 HLA class II histocompatibility antigen, DQ(6) alpha chain HLA-DQA2 0.0015
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0015
6167 Organic solute transporter subunit beta OSTB 0.0014
1507 Cytochrome c CYCS 0.0014
6166 Organic solute transporter subunit alpha OSTA 0.0014
2599 Tyrosine-protein kinase HCK HCK 0.0014
6859 Protein S100-A4 S100A4 0.0014
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0014
3670 Soluble cytochrome b562 precursor cybC 0.0013
3411 Cytochrome P450 121 cyp121 0.0013
561 Retinol-binding protein II, cellular RBP2 0.0013
35 Dehydrogenase/reductase SDR family member 4 DHRS4 0.0013
4073 Retinol dehydrogenase 11 RDH11 0.0013
4074 Retinol dehydrogenase 14 RDH14 0.0013
1097 Lecithin retinol acyltransferase LRAT 0.0013
589 Retinoid-binding protein 7 RBP7 0.0013
753 Retinol-binding protein III, cellular RBP5 0.0013
4071 Short-chain dehydrogenase/reductase 3 DHRS3 0.0013
4075 Photoreceptor outer segment all-trans retinol dehydrogenase RDH8 0.0013
863 Cellular retinaldehyde-binding protein RLBP1 0.0013
800 Retinol dehydrogenase 12 RDH12 0.0013
282 Interphotoreceptor retinoid-binding protein RBP3 0.0013
651 Retinol dehydrogenase 13 RDH13 0.0013
4072 All-trans-retinol 13,14-reductase RETSAT 0.0013
3291 Cytochrome c-552 cycA 0.0013
4927 Cytochrome c-552 nrfA 0.0013
4938 Cytochrome c-552 cycA 0.0013
4953 Cytochrome c-552 nrfA 0.0013
5217 Cytochrome c-552 cycM 0.0013
2617 Nitric oxide synthase oxygenase nos 0.0013
2701 Nitric oxide synthase oxygenase nos 0.0013
6211 Tubulin epsilon chain TUBE1 0.0013
6212 Tubulin gamma-1 chain TUBG1 0.0013
6210 Tubulin delta chain TUBD1 0.0013
3102 Flavohemoprotein hmp 0.0013
4969 Flavohemoprotein hmp 0.0013
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0013
860 Nicotinamide N-methyltransferase NNMT 0.0013
5626 Nucleoside diphosphate kinase B NME2 0.0013
699 Nicotinic acid receptor 1 GPR109A 0.0013
928 Nicotinic acid receptor 2 GPR109B 0.0013
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0013
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
1405 Thiopurine S-methyltransferase TPMT 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
2107 Microtubule-associated protein 1A MAP1A 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
1295 Fatty acid synthase FASN 0.0012
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0012
2972 6-deoxyerythronolide B hydroxylase eryF 0.0012
627 11-cis retinol dehydrogenase RDH5 0.0011
640 Aldehyde dehydrogenase 1A3 ALDH1A3 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
4608 Putative cytochrome P450 SCO1207 0.0011
4963 Putative cytochrome P450 SCO2884 0.0011
6254 Putative cytochrome P450 SCO6998 0.0011
6316 ADP-ribosylation factor 1 ARF1 0.0011
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
2461 D-alanyl-D-alanine carboxypeptidase Not Available 0.001
5756 D-alanyl-D-alanine carboxypeptidase dac 0.001
3238 Multidrug resistance protein mexA mexA 0.001
3709 Glycerol uptake facilitator protein glpF 0.001
3116 Bacterioferritin bfr 0.001
4906 Bacterioferritin bfr 0.001
4965 Bacterioferritin bfr 0.001
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.001
3173 Enolase eno 0.001
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.001
3393 TGF-beta receptor type-2 TGFBR2 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
5294 Nucleoside diphosphate kinase A NME1 0.001
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.001
345 Plasma retinol-binding protein RBP4 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
693 Hemoglobin subunit beta HBB 0.001
6228 Nuclear receptor coactivator 1 NCOA1 0.001
6837 Serine/threonine-protein kinase 17B STK17B 0.001
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.001
2268 Cholesterol oxidase choB 0.0009
2822 Cholesterol oxidase choA 0.0009
6268 Hydroxyacid oxidase 1 HAO1 0.0009
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0009
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0009
810 Heme oxygenase 1 HMOX1 0.0009
3391 Heme oxygenase 1 pbsA1 0.0009
1048 Protein S100-A13 S100A13 0.0009
2226 Protein S100-A12 S100A12 0.0009
2852 DNA mismatch repair protein mutL mutL 0.0009
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0009
1770 Phospholipase C PLCL1 0.0009
2841 Phospholipase C plc 0.0009
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0009
2283 Steroid Delta-isomerase ksi 0.0009
2920 Steroid Delta-isomerase ksi 0.0009
3191 Histidinol dehydrogenase hisD 0.0009
2132 Protein S100-B S100B 0.0009
740 Argininosuccinate synthase ASS1 0.0009
865 Argininosuccinate synthase ASS1 0.0009
2680 Argininosuccinate synthase argG 0.0009
3194 Argininosuccinate synthase argG 0.0009
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0008
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
6599 HTH-type transcriptional regulator ttgR ttgR 0.0008
500 Monocarboxylate transporter 4 SLC16A3 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
1025 Aquaporin-1 AQP1 0.0008
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0007
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0007
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0007
5818 Folate receptor alpha FOLR1 0.0007
2802 Endoglucanase G celCCG 0.0007
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0007
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0007
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0007
6241 Nuclear receptor coactivator 2 NCOA2 0.0007
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
125 DNA polymerase beta POLB 0.0007
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0007
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0006
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0006
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0006
5221 Cytochrome c3, 13 kDa Not Available 0.0006
3152 Cytochrome c'' cycA 0.0006
5220 Split-Soret cytochrome c Ddes_2150 0.0006
3700 Cytochrome c-552 precursor nrfA 0.0006
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0005
6743 Non-fluorescent flavoprotein luxF 0.0005
6753 Apolipoprotein M APOM 0.0005
2528 Fatty acid metabolism regulator protein fadR 0.0005
6740 Fatty acid metabolism regulator protein fadR 0.0005
6752 Guanylyl cyclase-activating protein 1 GUCA1A 0.0005
394 Calcineurin subunit B isoform 1 PPP3R1 0.0005
6742 Recoverin RCVRN 0.0005
6747 Chalcone/stilbene synthase family protein MT1417 0.0005
6741 Peroxisomal 3,2-trans-enoyl-CoA isomerase PECI 0.0005
6522 Hepatocyte nuclear factor 4-alpha HNF4A 0.0005
6751 Gag polyprotein gag 0.0005
6746 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform PPP3CA 0.0005
6749 Polyprotein Not Available 0.0005
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0005
3127 Nitrite reductase nirS 0.0005
3284 Nitrite reductase nirS 0.0005
5961 Insulin INS 0.0005
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0005
6527 Lymphocyte antigen 96 LY96 0.0005
6755 Poliovirus receptor PVR 0.0005
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0004
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0004
3405 Quinohaemoprotein ethanol dehydrogenase type-1 qheDH 0.0004
6750 ADP-ribosylation factor 6 ARF6 0.0004
4373 Medium-chain-fatty-acid--CoA ligase Not Available 0.0004
6524 Protein tonB tonB 0.0004
2616 Ganglioside GM2 activator GM2A 0.0004
2435 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase lpxC 0.0004
6613 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase lpxC 0.0004
2297 Genome polyprotein Not Available 0.0004
2322 Genome polyprotein Not Available 0.0004
2694 Genome polyprotein Not Available 0.0004
2719 Genome polyprotein Not Available 0.0004
2860 Genome polyprotein Not Available 0.0004
2928 Genome polyprotein Not Available 0.0004
3160 Genome polyprotein Not Available 0.0004
3260 Genome polyprotein Not Available 0.0004
4783 Genome polyprotein Not Available 0.0004
5726 Genome polyprotein Not Available 0.0004
5779 Genome polyprotein Not Available 0.0004
5867 Genome polyprotein Not Available 0.0004
6253 Genome polyprotein Not Available 0.0004
6301 Genome polyprotein Not Available 0.0004
6380 Genome polyprotein Not Available 0.0004
6381 Genome polyprotein Not Available 0.0004
6437 Genome polyprotein Not Available 0.0004
6520 Genome polyprotein Not Available 0.0004
6521 Genome polyprotein Not Available 0.0004
6652 Genome polyprotein Not Available 0.0004
6734 Genome polyprotein Not Available 0.0004
6735 Genome polyprotein Not Available 0.0004
6736 Genome polyprotein Not Available 0.0004
6737 Genome polyprotein Not Available 0.0004
6738 Genome polyprotein Not Available 0.0004
6739 Genome polyprotein Not Available 0.0004
6744 Genome polyprotein Not Available 0.0004
6748 Genome polyprotein Not Available 0.0004
6894 Genome polyprotein Not Available 0.0004
6898 Genome polyprotein Not Available 0.0004
864 Gag-Pol polyprotein gag-pol 0.0003
2237 Gag-Pol polyprotein gag-pol 0.0003
2326 Gag-Pol polyprotein gag-pol 0.0003
2451 Gag-Pol polyprotein gag-pol 0.0003
2901 Gag-Pol polyprotein gag-pol 0.0003
3165 Gag-Pol polyprotein gag-pol 0.0003
3722 Gag-Pol polyprotein gag-pol 0.0003
6306 Gag-Pol polyprotein gag-pol 0.0003
6624 Gag-Pol polyprotein gag-pol 0.0003
2240 Cell division protein kinase 2 CDK2 0.0003
2427 Ferrichrome-iron receptor fhuA 0.0003
6264 cAMP-dependent protein kinase inhibitor alpha PKIA 0.0003
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