DT-Web

DB00173 - Adenine


Identification
Name Adenine
Accession Number DB00173 (EXPT00520, NUTR00012)
Type small molecule
Description A purine base and a fundamental unit of adenine nucleotides. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 135.1267
Groups approved
Monoisotopic Weight 135.054495185
Pharmacology
Indication For nutritional supplementation, also for treating dietary shortage or imbalance
Mechanism of action Adenine forms adenosine, a nucleoside, when attached to ribose, and deoxyadenosine when attached to deoxyribose, and it forms adenosine triphosphate (ATP), a nucleotide, when three phosphate groups are added to adenosine. Adenosine triphosphate is used in cellular metabolism as one of the basic methods of transferring chemical energy between reactions. In older literature, adenine was sometimes called Vitamin B4Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Adenine phosphoribosyltransferase
Name Adenine phosphoribosyltransferase
Gene Name APRT
Pharmacological action unknown
Actions Not Available
References
  • Barrett C, Alley J, Pulido JC, Spurling H, Li P, Parsons T, Mallender WD, Bembenek ME: Configuration of a scintillation proximity assay for the activity assessment of recombinant human adenine phosphoribosyltransferase. Assay Drug Dev Technol. 2006 Dec;4(6):661-9. - Pubmed
  • Di Pietro V, Perruzza I, Amorini AM, Balducci A, Ceccarelli L, Lazzarino G, Barsotti P, Giardina B, Tavazzi B: Clinical, biochemical and molecular diagnosis of a compound homozygote for the 254 bp deletion-8 bp insertion of the APRT gene suffering from severe renal failure. Clin Biochem. 2007 Jan;40(1-2):73-80. Epub 2006 Oct 19. - Pubmed
  • Katahira R, Ashihara H: Profiles of purine biosynthesis, salvage and degradation in disks of potato (Solanum tuberosum L.) tubers. Planta. 2006 Dec;225(1):115-26. Epub 2006 Jul 15. - Pubmed
  • Katahira R, Ashihara H: Role of adenosine salvage in wound-induced adenylate biosynthesis in potato tuber slices. Plant Physiol Biochem. 2006 Oct;44(10):551-5. Epub 2006 Oct 9. - Pubmed
  • Boitz JM, Ullman B: Leishmania donovani singly deficient in HGPRT, APRT or XPRT are viable in vitro and within mammalian macrophages. Mol Biochem Parasitol. 2006 Jul;148(1):24-30. Epub 2006 Mar 15. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.804
MTA/SAH nucleosidase
Name MTA/SAH nucleosidase
Gene Name mtnN
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Singh V, Lee JE, Nunez S, Howell PL, Schramm VL: Transition state structure of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase from Escherichia coli and its similarity to transition state analogues. Biochemistry. 2005 Sep 6;44(35):11647-59. - Pubmed
  • Walker RD, Duerre JA: S-adenosylhomocysteine metabolism in various species. Can J Biochem. 1975 Mar;53(3):312-9. - Pubmed
  • Singh V, Schramm VL: Transition-state analysis of S. pneumoniae 5'-methylthioadenosine nucleosidase. J Am Chem Soc. 2007 Mar 14;129(10):2783-95. Epub 2007 Feb 14. - Pubmed
DTHybrid score 1.8078
Acetyl-CoA carboxylase 2
Name Acetyl-CoA carboxylase 2
Gene Name ACACB
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Rasmussen JT, Rosendal J, Knudsen J: Interaction of acyl-CoA binding protein (ACBP) on processes for which acyl-CoA is a substrate, product or inhibitor. Biochem J. 1993 Jun 15;292 ( Pt 3):907-13. - Pubmed
  • Witters LA, Mendel DB, Colliton JW: Modulation of acetyl-CoA carboxylase by inhibitors of IMP dehydrogenase: implications for insulin regulation. Arch Biochem Biophys. 1987 Jan;252(1):130-5. - Pubmed
  • Itani SI, Saha AK, Kurowski TG, Coffin HR, Tornheim K, Ruderman NB: Glucose autoregulates its uptake in skeletal muscle: involvement of AMP-activated protein kinase. Diabetes. 2003 Jul;52(7):1635-40. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.3947
Low molecular weight phosphotyrosine protein phosphatase
Name Low molecular weight phosphotyrosine protein phosphatase
Gene Name ACP1
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Wang S, Stauffacher CV, Van Etten RL: Structural and mechanistic basis for the activation of a low-molecular weight protein tyrosine phosphatase by adenine. Biochemistry. 2000 Feb 15;39(6):1234-42. - Pubmed
  • Magherini F, Gamberi T, Paoli P, Marchetta M, Biagini M, Raugei G, Camici G, Ramponi G, Modesti A: The in vivo tyrosine phosphorylation level of yeast immunophilin Fpr3 is influenced by the LMW-PTP Ltp1. Biochem Biophys Res Commun. 2004 Aug 20;321(2):424-31. - Pubmed
  • Ostanin K, Pokalsky C, Wang S, Van Etten RL: Cloning and characterization of a Saccharomyces cerevisiae gene encoding the low molecular weight protein-tyrosine phosphatase. J Biol Chem. 1995 Aug 4;270(31):18491-9. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.9121
Peroxisomal trans-2-enoyl-CoA reductase
Name Peroxisomal trans-2-enoyl-CoA reductase
Gene Name PECR
Pharmacological action unknown
Actions Not Available
References Not Available
DTHybrid score 0.6249
A/G-specific adenine glycosylase
Name A/G-specific adenine glycosylase
Gene Name mutY
Pharmacological action unknown
Actions Not Available
References Not Available
DTHybrid score 0.4777
Purine trans deoxyribosylase
Name Purine trans deoxyribosylase
Gene Name ptd
Pharmacological action unknown
Actions Not Available
References Not Available
DTHybrid score 1.8354
Serine/threonine-protein kinase SRPK2
Name Serine/threonine-protein kinase SRPK2
Gene Name SRPK2
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.5617
Holliday junction ATP-dependent DNA helicase ruvB
Name Holliday junction ATP-dependent DNA helicase ruvB
Gene Name ruvB
Pharmacological action unknown
Actions Not Available
References Not Available
DTHybrid score 0.0044
DNA
Name DNA
Gene Name Not Available
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Simon R, Heithoff DM, Mahan MJ, Samuel CE: Tissue Selective Proinflammatory Gene Induction in Mice Infected with Wild-Type Compared to DNA Adenine Methylase- or Flagella-deficient Salmonella. Infect Immun. 2007 Sep 24;. - Pubmed
  • Ichida H, Maeda K, Ichise H, Matsuyama T, Abe T, Yoneyama K, Koba T: In silico restriction landmark genome scanning analysis of Xanthomonas oryzae pathovar oryzae MAFF 311018. Biochem Biophys Res Commun. 2007 Nov 23;363(3):852-6. Epub 2007 Sep 24. - Pubmed
  • Mamdouh W, Dong M, Kelly RE, Kantorovich LN, Besenbacher F: Coexistence of Homochiral and Heterochiral Adenine Domains at the Liquid/Solid Interface. J Phys Chem B. 2007 Oct 5;. - Pubmed
DTHybrid score Not Available
S-methyl-5-thioadenosine phosphorylase
Name S-methyl-5-thioadenosine phosphorylase
Gene Name MTAP
Pharmacological action unknown
Actions Not Available
References
  • Chow WA, Bedell V, Gaytan P, Borden E, Goldblum J, Hicks D, Slovak ML: Methylthioadenosine phosphorylase gene deletions are frequently detected by fluorescence in situ hybridization in conventional chondrosarcomas. Cancer Genet Cytogenet. 2006 Apr 15;166(2):95-100. - Pubmed
  • Chattopadhyay S, Zhao R, Tsai E, Schramm VL, Goldman ID: The effect of a novel transition state inhibitor of methylthioadenosine phosphorylase on pemetrexed activity. Mol Cancer Ther. 2006 Oct;5(10):2549-55. - Pubmed
  • Singh V, Schramm VL: Transition-state structure of human 5'-methylthioadenosine phosphorylase. J Am Chem Soc. 2006 Nov 15;128(45):14691-6. - Pubmed
DTHybrid score 1.6289
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase
Name Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase
Gene Name cobT
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Maggio-Hall LA, Escalante-Semerena JC: Alpha-5,6-dimethylbenzimidazole adenine dinucleotide (alpha-DAD), a putative new intermediate of coenzyme B12 biosynthesis in Salmonella typhimurium. Microbiology. 2003 Apr;149(Pt 4):983-90. - Pubmed
  • Cheong CG, Escalante-Semerena JC, Rayment I: Structural investigation of the biosynthesis of alternative lower ligands for cobamides by nicotinate mononucleotide: 5,6-dimethylbenzimidazole phosphoribosyltransferase from Salmonella enterica. J Biol Chem. 2001 Oct 5;276(40):37612-20. Epub 2001 Jul 5. - Pubmed
  • Trzebiatowski JR, Escalante-Semerena JC: Purification and characterization of CobT, the nicotinate-mononucleotide:5,6-dimethylbenzimidazole phosphoribosyltransferase enzyme from Salmonella typhimurium LT2. J Biol Chem. 1997 Jul 11;272(28):17662-7. - Pubmed
DTHybrid score 1.9932

Enzymes


UDP-glucuronosyltransferase 1-1
Name UDP-glucuronosyltransferase 1-1
Gene Name UGT1A1
Actions inhibitor
References
  • -
  • Nishimura Y, Maeda S, Ikushiro S, Mackenzie PI, Ishii Y, Yamada H: Inhibitory effects of adenine nucleotides and related substances on UDP-glucuronosyltransferase: structure-effect relationships and evidence for an allosteric mechanism. Biochim Biophys Acta. 2007 Nov;1770(11):1557-66. Epub 2007 Aug 8. - Pubmed
DTHybrid score 0.369

Predictions


Id Partner name Gene Name Score
6289 Dual specificity protein phosphatase 23 DUSP23 0.3894
2653 Modification methylase RsrI rsrIM 0.1795
3959 Cell division protein kinase 4 CDK4 0.0748
1771 Cell division control protein 2 homolog CDK1 0.0747
3321 Cell division control protein 2 homolog CRK2 0.0747
4271 Anthranilate phosphoribosyltransferase trpD 0.0661
2794 Orotate phosphoribosyltransferase pyrE 0.0604
1714 Mitogen-activated protein kinase 3 MAPK3 0.058
2658 Catechol 1,2-dioxygenase catA 0.0574
4269 Hypoxanthine-guanine phosphoribosyltransferase, putative HGPRTase 0.0561
2300 Lysozyme E 0.0545
3633 Lysozyme R 0.0545
5597 Lysozyme 17 0.0545
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.05
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.05
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.05
1176 Mitogen-activated protein kinase 1 MAPK1 0.0487
87 Hypoxanthine-guanine phosphoribosyltransferase HPRT1 0.0468
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0438
1588 Multidrug resistance protein 1 ABCB1 0.0399
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0377
690 Acetyl-CoA carboxylase 1 ACACA 0.0354
2852 DNA mismatch repair protein mutL mutL 0.0334
495 Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial MCCC1 0.0325
547 Propionyl-CoA carboxylase alpha chain, mitochondrial PCCA 0.0325
177 Biotin--protein ligase HLCS 0.0324
81 Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial MCCC2 0.0324
2240 Cell division protein kinase 2 CDK2 0.032
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0303
4924 Cytochrome P450 2C8 CYP2C8 0.0303
105 Sodium-dependent multivitamin transporter SLC5A6 0.0295
4512 Cytochrome P450 3A4 CYP3A4 0.0289
771 Pyruvate carboxylase, mitochondrial PC 0.0276
2457 Bacillolysin nprS 0.0272
601 Propionyl-CoA carboxylase beta chain, mitochondrial PCCB 0.0271
6026 Alcohol dehydrogenase 6 ADH6 0.0266
3709 Glycerol uptake facilitator protein glpF 0.0265
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0265
3116 Bacterioferritin bfr 0.0265
4906 Bacterioferritin bfr 0.0265
4965 Bacterioferritin bfr 0.0265
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0265
3173 Enolase eno 0.0265
3393 TGF-beta receptor type-2 TGFBR2 0.0265
3238 Multidrug resistance protein mexA mexA 0.0265
4757 Cytochrome P450 2C9 CYP2C9 0.0258
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0252
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0242
2802 Endoglucanase G celCCG 0.0237
6459 Glycodelin PAEP 0.0213
851 5'-AMP-activated protein kinase subunit beta-2 PRKAB2 0.0212
388 AMP deaminase 1 AMPD1 0.0212
4200 Cytochrome P450 1A2 CYP1A2 0.0211
3191 Histidinol dehydrogenase hisD 0.021
3221 Cytochrome c4 cc4 0.021
1898 Cytochrome P450 1B1 CYP1B1 0.02
4311 tRNA TRDMT1 0.0195
4325 tRNA trmD 0.0195
4328 tRNA trmD 0.0195
1881 Hexokinase-1 HK1 0.0182
20 Prostaglandin G/H synthase 1 PTGS1 0.0181
6316 ADP-ribosylation factor 1 ARF1 0.0181
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0179
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0179
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0179
297 Adenylate cyclase type 1 ADCY1 0.0179
4118 Cytochrome P450 3A5 CYP3A5 0.0178
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0177
6016 Cytochrome P450 2C19 CYP2C19 0.0174
290 Prostaglandin G/H synthase 2 PTGS2 0.017
2684 Histidine triad nucleotide-binding protein 1 HINT1 0.017
10 Glycogen phosphorylase, liver form PYGL 0.017
1291 cAMP response element-binding protein CREB1 0.0167
281 5'-AMP-activated protein kinase subunit beta-1 PRKAB1 0.0163
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0162
444 Alcohol dehydrogenase 1B ADH1B 0.0157
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0157
587 Serum albumin ALB 0.0155
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0155
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0155
6030 Cytochrome P450 2B6 CYP2B6 0.0152
3390 Aminoglycoside 3'-phosphotransferase aphA 0.0147
6029 Aminoglycoside 3'-phosphotransferase aphA1 0.0147
5646 Galactokinase GALK1 0.0147
5265 FtsH ftsH 0.0147
5302 TrwB trwB 0.0147
6021 Adenosine kinase ADK 0.0147
6013 Cytochrome P450 2E1 CYP2E1 0.0146
904 Glutathione S-transferase P GSTP1 0.0145
4198 Fructose-1,6-bisphosphatase 1 FBP1 0.014
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.014
4119 Cytochrome P450 2D6 CYP2D6 0.0136
4373 Medium-chain-fatty-acid--CoA ligase Not Available 0.0136
5312 Kinesin-like protein KIF1A KIF1A 0.0134
504 Mast/stem cell growth factor receptor KIT 0.0132
2615 Chemotaxis protein cheA cheA 0.0125
3810 Catechol O-methyltransferase COMT 0.0125
26 Vascular endothelial growth factor receptor 3 FLT4 0.0125
2371 Pantothenate kinase coaA 0.0124
2892 Acetylglutamate kinase argB 0.0124
3550 Acetylglutamate kinase argB 0.0124
825 Arsenical pump-driving ATPase ASNA1 0.0124
3435 Arsenical pump-driving ATPase arsA 0.0124
2950 Inositol-trisphosphate 3-kinase A ITPKA 0.0124
5880 Thrombopoietin receptor MPL 0.012
32 Vascular endothelial growth factor receptor 1 FLT1 0.0119
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0119
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0118
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0118
2727 S-adenosylmethionine synthetase metK 0.0118
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0116
2817 Phosphoribosylglycinamide formyltransferase 2 purT 0.0114
5641 Rod shape-determining protein MreB TM_0588 0.0114
4178 DNA repair protein RAD51 homolog 1 RAD51 0.0114
5645 DNA topoisomerase 4 subunit B parE 0.0114
6227 DNA topoisomerase 4 subunit B parE 0.0114
3794 Osmolarity sensor protein envZ envZ 0.0114
5644 Sensor protein phoQ phoQ 0.0114
5643 General secretion pathway protein E epsE 0.0114
5642 Chaperone clpB clpB 0.0114
5649 Potassium-transporting ATPase B chain kdpB 0.0114
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0113
2358 cAMP-specific 3',5'-cyclic phosphodiesterase 4D PDE4D 0.0112
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.011
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0109
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0109
936 Ephrin type-A receptor 2 EPHA2 0.0105
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0105
1729 Solute carrier family 22 member 6 SLC22A6 0.0104
146 Androgen receptor AR 0.0104
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0103
2251 Thymidylate kinase tmk 0.0102
2254 Thymidylate kinase DTYMK 0.0102
3522 Thymidylate kinase tmk 0.0102
207 Glutathione synthetase GSS 0.01
5269 Glutathione synthetase gshB 0.01
2867 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase ispE 0.0098
4751 Mitogen-activated protein kinase 12 MAPK12 0.0097
740 Argininosuccinate synthase ASS1 0.0097
865 Argininosuccinate synthase ASS1 0.0097
2680 Argininosuccinate synthase argG 0.0097
3194 Argininosuccinate synthase argG 0.0097
6433 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 PFKFB4 0.0097
2397 Dihydroxyacetone kinase dhaK 0.0097
407 Vascular endothelial growth factor receptor 2 KDR 0.0096
319 Opioid receptor, sigma 1 OPRS1 0.0094
4192 DNA topoisomerase 2-beta TOP2B 0.0094
3822 Actin, alpha skeletal muscle ACTA1 0.0094
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0093
2299 UDP-N-acetylmuramate--L-alanine ligase murC 0.009
3231 Death-associated protein kinase 1 DAPK1 0.009
6107 Cytochrome P450 3A7 CYP3A7 0.0089
6024 Cytochrome P450 1A1 CYP1A1 0.0088
1721 Glycogen synthase kinase-3 beta GSK3B 0.0087
862 Multidrug resistance-associated protein 1 ABCC1 0.0087
2164 Multidrug resistance-associated protein 4 ABCC4 0.0087
4366 Riboflavin kinase/FMN adenylyltransferase TM_0857 0.0085
887 DNA gyrase subunit B gyrB 0.0083
4150 DNA gyrase subunit B gyrB 0.0083
6225 DNA gyrase subunit B gyrB 0.0083
5718 Cytochrome P450 2A6 CYP2A6 0.0081
467 Delta-type opioid receptor OPRD1 0.0081
696 Kappa-type opioid receptor OPRK1 0.0081
2697 Uridine-cytidine kinase 2 UCK2 0.0078
847 Mu-type opioid receptor OPRM1 0.0077
958 Insulin-like growth factor 1 receptor IGF1R 0.0076
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0075
766 Beta-2 adrenergic receptor ADRB2 0.0075
3689 Endoglucanase A celA 0.0074
5411 Slt-IIvB stxB2e 0.0074
5046 Ecotin eco 0.0074
5563 Galectin-2 LGALS2 0.0074
3009 Beta-glucanase Not Available 0.0074
5565 Inorganic polyphosphate/ATP-glucomannokinase ppgmk 0.0074
5554 D-galactose-binding periplasmic protein mglB 0.0074
3741 D-galactose-binding periplasmic protein precursor mglB 0.0074
1875 Pulmonary surfactant-associated protein D SFTPD 0.0074
5562 Hexokinase Not Available 0.0074
3793 Aspartate ammonia-lyase aspA 0.0074
5569 Endo-1,4-beta glucanase EngF engF 0.0074
5553 Endoglucanase E1 Acel_0614 0.0074
5568 Endoglucanase C307 celC307 0.0074
4670 Cellulase B celB 0.0074
4668 Laminarinase TM_0024 0.0074
3744 Endoglucanase SS precursor celS 0.0073
5570 Endoglucanase E-4 celD 0.0073
4667 BH0236 protein BH0236 0.0073
5559 Neopullulanase nplT 0.0073
4671 Endoglucanase C cenC 0.0073
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0072
4509 Acetoin(diacetyl) reductase budC 0.0069
4164 Potassium voltage-gated channel subfamily KQT member 5 KCNQ5 0.0069
1184 Interferon beta IFNB1 0.0069
4163 Potassium voltage-gated channel subfamily KQT member 4 KCNQ4 0.0069
6102 Arylamine N-acetyltransferase 2 NAT2 0.0069
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0068
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0067
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0066
228 Beta platelet-derived growth factor receptor PDGFRB 0.0065
5176 YtnJ moxC 0.0065
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0065
1503 Galectin-7 LGALS7 0.0064
3525 ADP-ribose pyrophosphatase, mitochondrial NUDT9 0.0064
2728 Glucan 1,4-alpha-maltotetraohydrolase amyP 0.0064
5056 Maltooligosyltrehalose trehalohydrolase, putative treZ 0.0064
5416 Coat protein VP1 Not Available 0.0064
4669 Endo-1,4-beta-xylanase A xynA 0.0064
4715 Endo-1,4-beta-xylanase A xlnA 0.0064
5560 Endo-1,4-beta-xylanase A xynA 0.0064
5247 Endo-1,4-beta-xylanase Not Available 0.0064
5248 Endo-1,4-beta-xylanase xlnA 0.0064
5250 Endo-1,4-beta-xylanase xyl 0.0064
5498 Maltoporin lamB 0.0064
5561 Maltoporin lamB 0.0064
2705 Dimethyl sulfoxide reductase dmsA 0.0064
4622 Amylase Not Available 0.0064
1836 Mitogen-activated protein kinase 10 MAPK10 0.0063
2324 Botulinum neurotoxin type B botB 0.0059
3153 Quinoprotein glucose dehydrogenase-B gdhB 0.0059
2856 Glucosamine-6-phosphate isomerase GNPDA1 0.0059
4819 Hydrolase Not Available 0.0059
5249 Hydrolase Not Available 0.0059
5436 Hydrolase Not Available 0.0059
3547 Enterotoxin type B entB 0.0059
2564 Glucan 1,4-alpha-maltohexaosidase Not Available 0.0059
4811 Amylosucrase ams 0.0059
2531 Alpha-amylase amyE 0.0059
2948 Alpha-amylase amy 0.0059
3169 Alpha-amylase Not Available 0.0059
2541 Neopullulanase 1 tvaI 0.0059
3747 Cellulase B precursor celB 0.0059
3091 Maltodextrin phosphorylase malP 0.0059
2606 Neopullulanase 2 tvaII 0.0059
2236 Casein kinase II subunit alpha CSNK2A1 0.0059
2826 Glucose--fructose oxidoreductase gfo 0.0058
4666 Fucose-binding lectin PA-IIL lecB 0.0058
2372 Bifunctional tail protein 9 0.0058
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0057
3087 Nicotinate-nucleotide adenylyltransferase nadD 0.0056
4469 Nicotinate-nucleotide adenylyltransferase nadD 0.0056
4992 Cytochrome c peroxidase Not Available 0.0056
3225 Shiga toxin B-chain stxB 0.0056
4830 Aldose 1-epimerase galM 0.0056
3365 Beta-amylase spoII 0.0056
5577 N5-carboxyaminoimidazole ribonucleotide mutase purE 0.0055
3792 KHG/KDPG aldolase [Includes: 4-hydroxy-2-oxoglutarate aldolase eda 0.0055
4695 UPF0124 protein yfiH yfiH 0.0055
5590 N utilization substance protein B homolog nusB 0.0055
5588 Cell division protein FtsY TM_0570 0.0055
5598 Glycerol uptake operon antiterminator-related protein TM_1436 0.0055
5587 Iron(III)-binding periplasmic protein fbpA 0.0055
5591 Complement component C8 gamma chain C8G 0.0055
5582 Regulator of transcription; stringent starvation protein A sspA 0.0055
2838 Ribose-5-phosphate isomerase A rpiA 0.0055
2952 Ribose-5-phosphate isomerase A rpiA 0.0055
5595 Ribose-5-phosphate isomerase A rpiA 0.0055
5593 Transferase Not Available 0.0055
4238 50S ribosomal protein L4 rplD 0.0055
5578 50S ribosomal protein L4 rplD 0.0055
6173 50S ribosomal protein L4 rplD 0.0055
6219 50S ribosomal protein L4 rplD 0.0055
5581 Beta-fructosidase bfrA 0.0055
5060 Intron-associated endonuclease 1 ITEVIR 0.0055
4375 Glutamine synthetase 1 glnA1 0.0055
5600 Pyruvate decarboxylase pdc 0.0055
5592 Ribonucleoside-diphosphate reductase subunit beta nrdF 0.0055
5583 RNA 3'-terminal phosphate cyclase rtcA 0.0055
5586 Pleckstrin homology domain-containing family A member 1 PLEKHA1 0.0055
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0055
5575 Short tail fiber protein 12 0.0055
5580 Hexon protein PII 0.0055
5574 Invasin YPTB1668 0.0055
5682 Ribonuclease pancreatic RNASE1 0.0055
4604 Liver carboxylesterase 1 CES1 0.0054
1675 Glucokinase GCK 0.0054
4662 Glucokinase glk 0.0054
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0054
6614 Lactase-like protein LCTL 0.0054
3030 Salivary alpha-amylase AMY1A 0.0053
2293 Cyclomaltodextrin glucanotransferase Not Available 0.0053
2508 Cyclomaltodextrin glucanotransferase cgt 0.0053
2523 Cyclomaltodextrin glucanotransferase cgt 0.0053
3207 Cyclomaltodextrin glucanotransferase amyA 0.0053
5304 UPF0166 protein TM_0021 TM_0021 0.0053
5266 Activator of hgdC 0.0053
5314 UPF0079 ATP-binding protein HI0065 HI_0065 0.0053
5293 Shikimate kinase 2 aroL 0.0053
2874 Nitrogenase iron protein 1 nifH1 0.0053
5287 Signaling protein Not Available 0.0053
5292 Putative partitioning protein TT_C1605 0.0053
3199 Phosphopantetheine adenylyltransferase coaD 0.0053
3543 Phosphopantetheine adenylyltransferase coaD 0.0053
3567 Phosphopantetheine adenylyltransferase coaD 0.0053
5289 Phosphopantetheine adenylyltransferase coaD 0.0053
4346 Polynucleotide kinase pseT 0.0053
5283 D-alanine--D-alanine ligase B ddlB 0.0053
5288 Shikimate kinase aroK 0.0053
5281 Plasmid segregation protein parM parM 0.0053
5305 Phosphoribosylaminoimidazole carboxylase ATPase subunit purK 0.0053
5299 D-alanine--D-alanine ligase ddl 0.0053
6598 D-alanine--D-alanine ligase ddl 0.0053
5275 Multidrug resistance ABC transporter ATP-binding and permease protein lmrA 0.0053
5276 Chromosomal replication initiator protein dnaA dnaA 0.0053
5259 Transcriptional regulator ntrC1 0.0053
6699 Transcriptional regulator Cgl2612 0.0053
5290 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0053
5638 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0053
5270 ATP-dependent Clp protease ATP-binding subunit clpX clpX 0.0053
5284 Large T antigen Not Available 0.0053
5291 Glycogen synthase 1 glgA1 0.0053
5264 DNA replication protein REP 0.0053
4794 Phosphoenolpyruvate carboxykinase [ATP] pckA 0.0053
5285 Kinesin heavy chain KIF5B 0.0053
5315 Chaperone protein htpG htpG 0.0053
1549 Heat shock 70 kDa protein 1 HSPA1A 0.0053
5277 Preprotein translocase subunit secA secA 0.0053
3777 ATP-dependent Clp protease ATP-binding subunit clpA clpA 0.0053
5308 Preprotein translocase secA 1 subunit secA1 0.0053
3982 Phosphoribosylformylglycinamidine synthase PFAS 0.0053
5261 Phosphoribosylformylglycinamidine synthase purL 0.0053
4272 POSSIBLE CELLULASE CELA1 celA1 0.0052
2448 Exoglucanase/xylanase [Includes: Exoglucanase cex 0.0052
3668 Maltose-binding periplasmic protein precursor malE 0.0051
2570 Tetanus toxin tetX 0.0051
3085 Molybdopterin-guanine dinucleotide biosynthesis protein A mobA 0.0051
3729 Citrate synthase gltA 0.0051
4575 Citrate synthase cit 0.0051
4580 Citrate synthase gltA 0.0051
5328 Prostaglandin F synthase Tb11.02.2310 0.0051
3132 Tryptophan synthase alpha chain trpA 0.005
6568 Tryptophan synthase alpha chain trpA 0.005
355 GMP synthase [glutamine-hydrolyzing] GMPS 0.0049
4353 GMP synthase [glutamine-hydrolyzing] guaA 0.0049
1467 Tumor necrosis factor ligand superfamily member 13B TNFSF13B 0.0049
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0049
2440 Endoglucanase F celCCF 0.0049
5006 RNASE4 protein RNASE4 0.0048
4533 Glyoxalase family protein BC_1747 0.0048
2430 Chondroitinase B cslB 0.0048
5599 3-carboxy-cis,cis-muconate cycloisomerase pcaB 0.0048
2555 Pol polyprotein pol 0.0048
3242 Pol polyprotein gag-pol 0.0048
3471 Pol polyprotein gag-pro-pol 0.0048
5256 Pol polyprotein pol 0.0048
6469 Pol polyprotein gag-pol 0.0048
6565 Pol polyprotein Not Available 0.0048
2521 Cell division protein ftsZ ftsZ 0.0048
3301 Cell division protein ftsZ ftsZ 0.0048
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0048
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0048
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0048
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0048
1760 Aminopeptidase N ANPEP 0.0047
6843 Aminopeptidase N pepN 0.0047
117 Sterol O-acyltransferase 1 SOAT1 0.0046
2245 Xylose isomerase xylA 0.0046
2253 Xylose isomerase xylA 0.0046
2260 Xylose isomerase xylA 0.0046
2431 Xylose isomerase xylA 0.0046
857 Malate dehydrogenase, mitochondrial MDH2 0.0046
2252 Endoglucanase 5A cel5A 0.0046
2149 Angiogenin ANG 0.0045
1024 Solute carrier family 22 member 11 SLC22A11 0.0045
2603 Beta-lactamase II blm 0.0045
4837 Cag-alfa cag-alfa 0.0045
4774 NTPase P4 Not Available 0.0045
6277 Heat shock cognate 71 kDa protein HSPA8 0.0045
3583 6-phosphogluconolactonase pgl 0.0045
4839 DNA polymerase III subunit tau dnaX 0.0045
4838 PMS1 protein homolog 2 PMS2 0.0044
2270 Dephospho-CoA kinase coaE 0.0044
5189 Trimethylamine dehydrogenase tmd 0.0044
2284 Adenylate kinase adk 0.0044
2296 Adenylate kinase adk 0.0044
2311 Adenylate kinase adk 0.0044
2312 Adenylate kinase Not Available 0.0044
1123 Eosinophil cationic protein RNASE3 0.0044
4106 Guanylate kinase GUK1 0.0044
4516 Guanylate kinase gmk 0.0044
413 Amidophosphoribosyltransferase PPAT 0.0044
2515 Amidophosphoribosyltransferase purF 0.0044
3714 Amidophosphoribosyltransferase purF 0.0044
3470 Hypothetical protein MG245 homolog MPN_348 0.0044
5295 2-keto-3-deoxy-gluconate kinase TT_P0036 0.0044
2751 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0044
3426 Glutamine synthetase glnA 0.0044
3987 Glutamine synthetase GLUL 0.0044
3175 Glutamate--cysteine ligase gshA 0.0044
2723 Cholera enterotoxin subunit B ctxB 0.0043
2869 1-deoxy-D-xylulose 5-phosphate reductoisomerase dxr 0.0043
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0043
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0043
2942 Sialidase nanH 0.0043
3546 Sialidase nedA 0.0043
2805 Heparan sulfate glucosamine 3-O-sulfotransferase 3A1 HS3ST3A1 0.0042
3486 Fumarate hydratase class II fumC 0.0042
340 Apoptotic protease-activating factor 1 APAF1 0.0042
2452 Tryptophanyl-tRNA synthetase trpS 0.0042
2286 Isocitrate dehydrogenase [NADP] icd 0.0042
2302 Isocitrate dehydrogenase [NADP] icd 0.0042
2771 Isocitrate dehydrogenase [NADP] icd 0.0042
4513 Pancreatic alpha-amylase AMY2A 0.0042
941 Betaine--homocysteine S-methyltransferase 1 BHMT 0.0042
332 Beta-lactamase blaZ 0.0041
2478 Beta-lactamase ampC 0.0041
2613 Beta-lactamase ampC 0.0041
2635 Beta-lactamase ampC 0.0041
2700 Beta-lactamase penP 0.0041
5445 Beta-lactamase blaB 0.0041
6019 Beta-lactamase SHV-7 0.0041
6701 Beta-lactamase cphA 0.0041
2427 Ferrichrome-iron receptor fhuA 0.0041
2683 Mono-ADP-ribosyltransferase C3 C3 0.0041
411 Glycine N-methyltransferase GNMT 0.0041
2390 Nonsecretory ribonuclease RNASE2 0.0041
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0041
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0041
5300 Antigen peptide transporter 1 TAP1 0.004
2922 Glycerol kinase glpK 0.004
5271 Focal adhesion kinase 1 PTK2 0.004
2936 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.004
5184 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.004
3478 Glucose-1-phosphate thymidylyltransferase rmlA 0.0039
4277 Glucose-1-phosphate thymidylyltransferase rmlA 0.0039
2282 Protein recA recA 0.0039
2315 Protein recA recA 0.0039
2332 Protein recA recA 0.0039
5263 Protein recA recA 0.0039
6142 Solute carrier family 22 member 8 SLC22A8 0.0039
408 Riboflavin kinase RFK 0.0038
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0038
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0038
3669 Ribokinase rbsK 0.0037
6857 [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial PDK2 0.0037
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0037
3856 Fibroblast growth factor receptor 3 FGFR3 0.0037
5579 Carboxypeptidase B CPB1 0.0037
1630 Integrin beta-2 ITGB2 0.0036
3384 Macrophage migration inhibitory factor MIF 0.0036
6390 Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 ATP2A1 0.0036
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0036
788 Creatine kinase M-type CKM 0.0035
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0035
6137 Multidrug resistance-associated protein 6 ABCC6 0.0035
2334 Dethiobiotin synthetase bioD 0.0034
6555 Dethiobiotin synthetase bioD 0.0034
6085 Fatty acid-binding protein, intestinal FABP2 0.0034
1152 Glycogen phosphorylase, muscle form PYGM 0.0034
61 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0034
2644 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0034
2710 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0034
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.0033
48 Pyridoxal kinase PDXK 0.0032
844 Epidermal growth factor receptor EGFR 0.0032
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0032
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0032
702 UMP-CMP kinase CMPK1 0.0032
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0032
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0032
2091 Endoplasmin HSP90B1 0.0031
6395 Myosin-14 MYH14 0.0031
2317 UDP-N-acetylmuramoylalanine--D-glutamate ligase murD 0.0031
6148 Multidrug resistance-associated protein 7 ABCC10 0.0031
1422 Serine/threonine-protein kinase 6 AURKA 0.003
2981 Phospholipase A2, membrane associated PLA2G2A 0.003
6147 Solute carrier family 22 member 3 SLC22A3 0.003
6044 Serum paraoxonase/lactonase 3 PON3 0.0029
3379 Kinesin-like protein KIF11 KIF11 0.0029
3456 Heat shock protein HSP 90-beta HSP90AB1 0.0029
6136 Multidrug resistance-associated protein 5 ABCC5 0.0029
822 Aldose reductase AKR1B1 0.0029
2021 Thrombomodulin THBD 0.0028
509 Thymidine kinase TK 0.0028
570 Thymidine kinase TK 0.0028
2559 Thymidine kinase TK 0.0028
3430 Thymidine kinase tdk 0.0028
3518 Thymidine kinase TK 0.0028
5301 Thymidine kinase tdk 0.0028
5771 Thymidine kinase ORF36 0.0028
7009 Thymidine kinase ORF36 0.0028
5798 Mitogen-activated protein kinase 11 MAPK11 0.0028
6106 Cytochrome P450 2C18 CYP2C18 0.0027
572 Integrin alpha-L ITGAL 0.0027
5294 Nucleoside diphosphate kinase A NME1 0.0027
1353 DNA topoisomerase 1 TOP1 0.0027
3552 DNA topoisomerase 1 topA 0.0027
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0027
1192 Sulfotransferase 1A1 SULT1A1 0.0027
70 Type-1 angiotensin II receptor AGTR1 0.0026
267 Plasminogen activator inhibitor 1 SERPINE1 0.0026
4773 Deoxycytidine kinase DCK 0.0026
1275 Estrogen sulfotransferase SULT1E1 0.0025
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0025
4122 Histone deacetylase 2 HDAC2 0.0025
760 Fibroblast growth factor 1 FGF1 0.0025
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0025
1050 Bile salt sulfotransferase SULT2A1 0.0024
776 Bile salt export pump ABCB11 0.0024
6221 Steroid hormone receptor ERR1 ESRRA 0.0024
811 Translocator protein TSPO 0.0024
908 Glutathione S-transferase theta-1 GSTT1 0.0023
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0022
6143 Solute carrier family 22 member 7 SLC22A7 0.0022
3937 Fatty-acid amide hydrolase FAAH 0.0022
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0022
6042 Prostaglandin reductase 2 PTGR2 0.0021
6220 Aryl hydrocarbon receptor AHR 0.0021
1618 High affinity nerve growth factor receptor NTRK1 0.0021
5787 Angiopoietin-1 receptor TEK 0.0021
165 FL cytokine receptor FLT3 0.0021
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0021
823 Fibroblast growth factor receptor 2 FGFR2 0.002
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.002
1792 Tissue-type plasminogen activator PLAT 0.002
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0019
6043 Putative G-protein coupled receptor 44 GPR44 0.0019
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0019
273 Apoptosis regulator Bcl-2 BCL2 0.0019
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0019
3809 Estrogen-related receptor gamma ESRRG 0.0019
284 DNA-directed RNA polymerase beta chain rpoB 0.0018
5773 DNA-directed RNA polymerase beta chain rpoB 0.0018
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0018
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0018
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0018
817 DNA topoisomerase 2-alpha TOP2A 0.0018
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0017
3923 Cholinesterase BCHE 0.0016
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0016
1313 Lactoylglutathione lyase GLO1 0.0016
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0016
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0016
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0016
468 Cytochrome P450 4A11 CYP4A11 0.0015
6031 Cytochrome P450 3A43 CYP3A43 0.0014
275 Arachidonate 5-lipoxygenase ALOX5 0.0014
6141 Sodium/bile acid cotransporter SLC10A1 0.0014
952 Dipeptidyl peptidase 4 DPP4 0.0014
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0013
756 Sex hormone-binding globulin SHBG 0.0013
3811 Cytochrome P450 19A1 CYP19A1 0.0013
869 Estrogen receptor beta ESR2 0.0011
373 Transthyretin TTR 0.0011
136 Estrogen receptor ESR1 0.001
6144 Solute carrier family 22 member 2 SLC22A2 0.0009
6145 Solute carrier family 22 member 1 SLC22A1 0.0009
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