DT-Web

DB02452 - Thymidine-5'-Triphosphate


Identification
Name Thymidine-5'-Triphosphate
Accession Number DB02452 (EXPT03131)
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 482.1683
Groups experimental
Monoisotopic Weight 481.989262798
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Glucose-1-phosphate thymidylyltransferase
Name Glucose-1-phosphate thymidylyltransferase
Gene Name rmlA
Pharmacological action unknown
Actions Not Available
References Not Available
DTHybrid score 0.9493
Glucose-1-phosphate thymidylyltransferase 2
Name Glucose-1-phosphate thymidylyltransferase 2
Gene Name rmlA2
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.91
DNA primase/helicase
Name DNA primase/helicase
Gene Name 4
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.124
Glucose-1-phosphate thymidylyltransferase
Name Glucose-1-phosphate thymidylyltransferase
Gene Name rmlA
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.9493
Thymidine kinase 2, mitochondrial
Name Thymidine kinase 2, mitochondrial
Gene Name TK2
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score Not Available
Thymidine kinase
Name Thymidine kinase
Gene Name tdk
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.1299
Ribonucleoside-diphosphate reductase 2 alpha subunit
Name Ribonucleoside-diphosphate reductase 2 alpha subunit
Gene Name nrdE
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.3053
Thymidine kinase, cytosolic
Name Thymidine kinase, cytosolic
Gene Name TK1
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.8724
Anaerobic ribonucleoside-triphosphate reductase
Name Anaerobic ribonucleoside-triphosphate reductase
Gene Name NRDD
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.4718
Thymidylate kinase
Name Thymidylate kinase
Gene Name tmk
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.2183

Predictions


Id Partner name Gene Name Score
2254 Thymidylate kinase DTYMK 1.2183
3522 Thymidylate kinase tmk 1.2183
2282 Protein recA recA 0.2896
2315 Protein recA recA 0.2896
2332 Protein recA recA 0.2896
5263 Protein recA recA 0.2896
125 DNA polymerase beta POLB 0.2768
2712 Deoxycytidine triphosphate deaminase dcd 0.2762
3023 DNA polymerase I, thermostable polA 0.276
3598 dTDP-4-dehydrorhamnose reductase rfbD 0.1544
5294 Nucleoside diphosphate kinase A NME1 0.1521
3524 DNA beta-glucosyltransferase bgt 0.1419
4504 WbpP Not Available 0.1309
509 Thymidine kinase TK 0.1299
570 Thymidine kinase TK 0.1299
2559 Thymidine kinase TK 0.1299
3518 Thymidine kinase TK 0.1299
5301 Thymidine kinase tdk 0.1299
5771 Thymidine kinase ORF36 0.1299
7009 Thymidine kinase ORF36 0.1299
2439 Alpha,alpha-trehalose-phosphate synthase [UDP-forming] otsA 0.1236
2280 Listeriolysin regulatory protein prfA 0.1195
2762 UDP-glucose 4-epimerase GALE 0.1105
3461 UDP-glucose 4-epimerase galE 0.1105
2333 6,7-dimethyl-8-ribityllumazine synthase ribH 0.0979
2642 6,7-dimethyl-8-ribityllumazine synthase ribH 0.0979
3216 6,7-dimethyl-8-ribityllumazine synthase ribH 0.0979
24 Thymidylate synthase TMP1 0.0944
359 Thymidylate synthase TYMS 0.0944
2626 Thymidylate synthase thyA 0.0944
2729 Thymidylate synthase thyA 0.0944
5352 Thymidylate synthase THYA 0.0944
3755 Nucleoside-specific channel-forming protein tsx precursor tsx 0.077
3639 Thymidine phosphorylase deoA 0.0749
3936 Thymidine phosphorylase TYMP 0.0749
3101 Glucose-1-phosphatase agp 0.0685
4275 PCZA361.16 Not Available 0.067
4276 DNA polymerase III subunit epsilon dnaQ 0.067
4427 TDP-glucose-4,6-dehydratase desIV 0.0618
3177 dTDP-glucose 4,6-dehydratase rfbB 0.0617
4499 dTDP-glucose 4,6-dehydratase rmlB 0.0617
3028 dTDP-4-dehydrorhamnose 3,5-epimerase rfbC 0.061
4294 DTDP-4-dehydrorhamnose 3,5-epimerase rmlC 0.061
5127 DTDP-4-dehydrorhamnose 3,5-epimerase rmlC 0.061
1353 DNA topoisomerase 1 TOP1 0.0597
3552 DNA topoisomerase 1 topA 0.0597
3091 Maltodextrin phosphorylase malP 0.055
2257 Uridine phosphorylase udp 0.0547
5132 Uridine phosphorylase udp 0.0547
2503 Phosphomannomutase/phosphoglucomutase algC 0.0499
2632 Adenylosuccinate synthetase purA 0.0459
3323 Adenylosuccinate synthetase purA 0.0459
3975 Adenylosuccinate synthetase ADSS 0.0459
4598 Adenylosuccinate synthetase Adss 0.0459
6817 Adenylosuccinate synthetase purA 0.0459
2756 Geranyltranstransferase ispA 0.0458
6171 Solute carrier family 28 member 3 SLC28A3 0.0455
2434 NH(3)-dependent NAD(+) synthetase nadE 0.044
2910 NH(3)-dependent NAD(+) synthetase nadE 0.044
3217 NH(3)-dependent NAD(+) synthetase nadE 0.044
1729 Solute carrier family 22 member 6 SLC22A6 0.0433
2586 Isopentenyl-diphosphate Delta-isomerase idi 0.0415
5187 Isopentenyl-diphosphate delta-isomerase fni 0.0415
5199 Isopentenyl-diphosphate delta-isomerase fni 0.0415
2427 Ferrichrome-iron receptor fhuA 0.0318
1152 Glycogen phosphorylase, muscle form PYGM 0.031
4217 Telomerase reverse transcriptase TERT 0.0254
6145 Solute carrier family 22 member 1 SLC22A1 0.0254
6136 Multidrug resistance-associated protein 5 ABCC5 0.0117
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0103
6143 Solute carrier family 22 member 7 SLC22A7 0.0098
1024 Solute carrier family 22 member 11 SLC22A11 0.0097
2164 Multidrug resistance-associated protein 4 ABCC4 0.0097
6144 Solute carrier family 22 member 2 SLC22A2 0.0089
6142 Solute carrier family 22 member 8 SLC22A8 0.0086
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0086
5718 Cytochrome P450 2A6 CYP2A6 0.0086
587 Serum albumin ALB 0.0078
4924 Cytochrome P450 2C8 CYP2C8 0.0071
6016 Cytochrome P450 2C19 CYP2C19 0.0068
1588 Multidrug resistance protein 1 ABCB1 0.0066
4757 Cytochrome P450 2C9 CYP2C9 0.0065
4512 Cytochrome P450 3A4 CYP3A4 0.0058
5591 Complement component C8 gamma chain C8G 0.0053
5598 Glycerol uptake operon antiterminator-related protein TM_1436 0.0053
5577 N5-carboxyaminoimidazole ribonucleotide mutase purE 0.0053
3792 KHG/KDPG aldolase [Includes: 4-hydroxy-2-oxoglutarate aldolase eda 0.0053
5582 Regulator of transcription; stringent starvation protein A sspA 0.0053
5587 Iron(III)-binding periplasmic protein fbpA 0.0053
2838 Ribose-5-phosphate isomerase A rpiA 0.0053
2952 Ribose-5-phosphate isomerase A rpiA 0.0053
5595 Ribose-5-phosphate isomerase A rpiA 0.0053
5590 N utilization substance protein B homolog nusB 0.0053
5593 Transferase Not Available 0.0053
5588 Cell division protein FtsY TM_0570 0.0053
5592 Ribonucleoside-diphosphate reductase subunit beta nrdF 0.0053
2300 Lysozyme E 0.0053
3633 Lysozyme R 0.0053
5597 Lysozyme 17 0.0053
5575 Short tail fiber protein 12 0.0053
5583 RNA 3'-terminal phosphate cyclase rtcA 0.0053
4238 50S ribosomal protein L4 rplD 0.0053
5578 50S ribosomal protein L4 rplD 0.0053
6173 50S ribosomal protein L4 rplD 0.0053
6219 50S ribosomal protein L4 rplD 0.0053
4695 UPF0124 protein yfiH yfiH 0.0053
5581 Beta-fructosidase bfrA 0.0053
5060 Intron-associated endonuclease 1 ITEVIR 0.0053
5600 Pyruvate decarboxylase pdc 0.0053
4375 Glutamine synthetase 1 glnA1 0.0053
5586 Pleckstrin homology domain-containing family A member 1 PLEKHA1 0.0053
5580 Hexon protein PII 0.0053
5574 Invasin YPTB1668 0.0053
3087 Nicotinate-nucleotide adenylyltransferase nadD 0.0047
4469 Nicotinate-nucleotide adenylyltransferase nadD 0.0047
4992 Cytochrome c peroxidase Not Available 0.0047
3085 Molybdopterin-guanine dinucleotide biosynthesis protein A mobA 0.0047
3729 Citrate synthase gltA 0.0046
4575 Citrate synthase cit 0.0046
4580 Citrate synthase gltA 0.0046
5328 Prostaglandin F synthase Tb11.02.2310 0.0046
3132 Tryptophan synthase alpha chain trpA 0.0046
6568 Tryptophan synthase alpha chain trpA 0.0046
355 GMP synthase [glutamine-hydrolyzing] GMPS 0.0046
4353 GMP synthase [glutamine-hydrolyzing] guaA 0.0046
5006 RNASE4 protein RNASE4 0.0046
4533 Glyoxalase family protein BC_1747 0.0046
5599 3-carboxy-cis,cis-muconate cycloisomerase pcaB 0.0046
2555 Pol polyprotein pol 0.0046
3242 Pol polyprotein gag-pol 0.0046
3471 Pol polyprotein gag-pro-pol 0.0046
5256 Pol polyprotein pol 0.0046
6469 Pol polyprotein gag-pol 0.0046
6565 Pol polyprotein Not Available 0.0046
1467 Tumor necrosis factor ligand superfamily member 13B TNFSF13B 0.0043
2521 Cell division protein ftsZ ftsZ 0.0043
3301 Cell division protein ftsZ ftsZ 0.0043
4373 Medium-chain-fatty-acid--CoA ligase Not Available 0.0043
2149 Angiogenin ANG 0.0043
2603 Beta-lactamase II blm 0.0042
3583 6-phosphogluconolactonase pgl 0.0042
4366 Riboflavin kinase/FMN adenylyltransferase TM_0857 0.0041
2869 1-deoxy-D-xylulose 5-phosphate reductoisomerase dxr 0.004
2942 Sialidase nanH 0.004
3546 Sialidase nedA 0.004
857 Malate dehydrogenase, mitochondrial MDH2 0.004
3486 Fumarate hydratase class II fumC 0.004
2286 Isocitrate dehydrogenase [NADP] icd 0.004
2302 Isocitrate dehydrogenase [NADP] icd 0.004
2771 Isocitrate dehydrogenase [NADP] icd 0.004
2805 Heparan sulfate glucosamine 3-O-sulfotransferase 3A1 HS3ST3A1 0.0039
2697 Uridine-cytidine kinase 2 UCK2 0.0038
1123 Eosinophil cationic protein RNASE3 0.0038
332 Beta-lactamase blaZ 0.0037
2478 Beta-lactamase ampC 0.0037
2613 Beta-lactamase ampC 0.0037
2635 Beta-lactamase ampC 0.0037
2700 Beta-lactamase penP 0.0037
5445 Beta-lactamase blaB 0.0037
6019 Beta-lactamase SHV-7 0.0037
6701 Beta-lactamase cphA 0.0037
941 Betaine--homocysteine S-methyltransferase 1 BHMT 0.0037
2936 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0037
5184 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0037
2452 Tryptophanyl-tRNA synthetase trpS 0.0037
5579 Carboxypeptidase B CPB1 0.0035
3384 Macrophage migration inhibitory factor MIF 0.0034
411 Glycine N-methyltransferase GNMT 0.0034
128 Adenine phosphoribosyltransferase APRT 0.0032
5682 Ribonuclease pancreatic RNASE1 0.0027
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0027
822 Aldose reductase AKR1B1 0.0027
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0025
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.002
↑