DT-Web

DB03723 - 2'-Deoxy-Thymidine-Beta-L-Rhamnose


Identification
Name 2'-Deoxy-Thymidine-Beta-L-Rhamnose
Accession Number DB03723 (EXPT03108)
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 548.3296
Groups experimental
Monoisotopic Weight 548.080841196
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Glucose-1-phosphate thymidylyltransferase
Name Glucose-1-phosphate thymidylyltransferase
Gene Name rmlA
Pharmacological action unknown
Actions Not Available
References Not Available
DTHybrid score 0.0365
dTDP-4-dehydrorhamnose reductase
Name dTDP-4-dehydrorhamnose reductase
Gene Name rfbD
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.6615

Predictions


Id Partner name Gene Name Score
2251 Thymidylate kinase tmk 0.0807
2254 Thymidylate kinase DTYMK 0.0807
3522 Thymidylate kinase tmk 0.0807
3101 Glucose-1-phosphatase agp 0.0685
4427 TDP-glucose-4,6-dehydratase desIV 0.0678
3177 dTDP-glucose 4,6-dehydratase rfbB 0.0677
4499 dTDP-glucose 4,6-dehydratase rmlB 0.0677
3028 dTDP-4-dehydrorhamnose 3,5-epimerase rfbC 0.061
4294 DTDP-4-dehydrorhamnose 3,5-epimerase rmlC 0.061
5127 DTDP-4-dehydrorhamnose 3,5-epimerase rmlC 0.061
3091 Maltodextrin phosphorylase malP 0.055
2503 Phosphomannomutase/phosphoglucomutase algC 0.0499
509 Thymidine kinase TK 0.0455
570 Thymidine kinase TK 0.0455
2559 Thymidine kinase TK 0.0455
3430 Thymidine kinase tdk 0.0455
3518 Thymidine kinase TK 0.0455
5301 Thymidine kinase tdk 0.0455
5771 Thymidine kinase ORF36 0.0455
7009 Thymidine kinase ORF36 0.0455
3481 Glucose-1-phosphate thymidylyltransferase 2 rmlA2 0.0405
3755 Nucleoside-specific channel-forming protein tsx precursor tsx 0.0385
3478 Glucose-1-phosphate thymidylyltransferase rmlA 0.0365
3299 DNA primase/helicase 4 0.0339
4275 PCZA361.16 Not Available 0.0326
4276 DNA polymerase III subunit epsilon dnaQ 0.0326
3244 Ribonucleoside-diphosphate reductase 2 alpha subunit nrdE 0.0312
1152 Glycogen phosphorylase, muscle form PYGM 0.031
1353 DNA topoisomerase 1 TOP1 0.0296
3552 DNA topoisomerase 1 topA 0.0296
2633 Anaerobic ribonucleoside-triphosphate reductase NRDD 0.0294
2257 Uridine phosphorylase udp 0.0273
5132 Uridine phosphorylase udp 0.0273
2320 Thymidine kinase, cytosolic TK1 0.0262
6171 Solute carrier family 28 member 3 SLC28A3 0.0225
24 Thymidylate synthase TMP1 0.0177
359 Thymidylate synthase TYMS 0.0177
2626 Thymidylate synthase thyA 0.0177
2729 Thymidylate synthase thyA 0.0177
5352 Thymidylate synthase THYA 0.0177
6145 Solute carrier family 22 member 1 SLC22A1 0.0127
3087 Nicotinate-nucleotide adenylyltransferase nadD 0.0107
4469 Nicotinate-nucleotide adenylyltransferase nadD 0.0107
4506 Myo-inositol-1-phosphate synthase-related protein TM_1419 0.0069
4428 Redox-sensing transcriptional repressor rex rex 0.0069
4336 Glyceraldehyde 3-phosphate dehydrogenase Not Available 0.0069
4436 Glyceraldehyde 3-phosphate dehydrogenase tthHB8IM 0.0069
4418 AGR_L_3209p AGR_L_3209 0.0069
4446 3alpha-hydroxysteroid dehydrogenase/carbonyl reductase Not Available 0.0069
4472 Glucose 1-dehydrogenase Not Available 0.0069
180 D-3-phosphoglycerate dehydrogenase PHGDH 0.0069
3726 D-3-phosphoglycerate dehydrogenase serA 0.0069
4291 D-3-phosphoglycerate dehydrogenase serA 0.0069
4456 Inorganic polyphosphate/ATP-NAD kinase ppnK 0.0069
4448 L-2-hydroxyisocaproate dehydrogenase Not Available 0.0069
4500 L-lactate dehydrogenase 2 ldh2 0.0069
4447 Hypothetical protein yhfP yhfP 0.0069
3381 Alcohol dehydrogenase Not Available 0.0069
4508 Alcohol dehydrogenase adhA 0.0069
4414 Dehydrogenase TT_P0035 0.0069
2350 3-isopropylmalate dehydrogenase leuB 0.0069
3092 3-isopropylmalate dehydrogenase leuB 0.0069
4471 CDP-D-glucose-4,6-dehydratase ascB 0.0069
4507 Alanine dehydrogenase ald 0.0069
4455 Glycerol dehydrogenase gldA 0.0069
4497 Benzyl alcohol dehydrogenase xylB 0.0069
4449 ADP-ribosyltransferase Not Available 0.0069
3735 NAD(P) transhydrogenase subunit alpha part 1 pntAA 0.0069
4502 Formate dehydrogenase Not Available 0.0069
4487 Transcriptional regulator nadR nadR 0.0069
4495 3-oxoacyl-(Acyl carrier protein) reductase TM_1169 0.0069
4435 L-aspartate dehydrogenase nadX 0.0069
4451 Vip2Ac vip2Ac 0.0069
4423 Levodione reductase lvr 0.0069
4505 Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase bphB 0.0069
4443 Quinate/shikimate dehydrogenase ydiB 0.0069
3729 Citrate synthase gltA 0.0069
4575 Citrate synthase cit 0.0069
4580 Citrate synthase gltA 0.0069
4475 Hypothetical protein Rv0046c/MT0052 ino1 0.0069
4466 Glutathione-independent formaldehyde dehydrogenase fdhA 0.0069
4467 Alpha-glucosidase, putative TM_0752 0.0069
4503 NADPH-flavin oxidoreductase frp 0.006
4486 Phenol 2-hydroxylase component B pheA2 0.006
2831 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase Not Available 0.006
3059 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase fabG3 0.006
4509 Acetoin(diacetyl) reductase budC 0.006
126 D-lactate dehydrogenase dld 0.006
3545 D-lactate dehydrogenase Not Available 0.006
4510 D-lactate dehydrogenase ldhA 0.006
3615 Dihydrodipicolinate reductase dapB 0.006
3618 Dihydrodipicolinate reductase dapB 0.006
4462 Dihydrodipicolinate reductase dapB 0.006
4484 2,5-diketo-D-gluconic acid reductase A dkgA 0.006
4496 C-terminal-binding protein 1 CTBP1 0.006
2424 L-lactate dehydrogenase ldh 0.006
2641 L-lactate dehydrogenase Not Available 0.006
4437 L-lactate dehydrogenase ldh 0.006
4442 L-lactate dehydrogenase ldh 0.006
1199 GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1 ART1 0.006
3401 D-2-hydroxyisocaproate dehydrogenase Not Available 0.006
4498 Ornithine cyclodeaminase PP3533 0.006
3081 3-dehydroquinate synthase aroB 0.006
2018 Deoxyhypusine synthase DHPS 0.006
4482 UDP-galactose 4-epimerase galE 0.006
4439 Ferredoxin reductase bphA4 0.006
6698 Dehydrogenase/reductase SDR family member 4-like 2 DHRS4L2 0.006
2538 6-phospho-beta-glucosidase bglT bglT 0.006
2393 Maltose-6'-phosphate glucosidase glvA 0.006
3671 7-alpha-hydroxysteroid dehydrogenase hdhA 0.006
2881 Gamma-aminobutyraldehyde dehydrogenase prr 0.006
2591 Urocanate hydratase hutU 0.006
2507 Diphtheria toxin Not Available 0.006
2336 2,3-diketo-L-gulonate reductase dlgD 0.006
2967 CDP-paratose 2-epimerase rfbE 0.006
4450 Iota toxin component Ia Not Available 0.006
4477 Dihydrolipoyl dehydrogenase lpdV 0.006
5077 Dihydrolipoyl dehydrogenase Not Available 0.006
5117 Dihydrolipoyl dehydrogenase lpd 0.006
579 Alcohol dehydrogenase class 4 mu/sigma chain ADH7 0.0057
816 Biliverdin reductase A BLVRA 0.0057
792 Aldehyde dehydrogenase, dimeric NADP-preferring ALDH3A1 0.0057
316 4-trimethylaminobutyraldehyde dehydrogenase ALDH9A1 0.0057
3736 Glyceraldehyde-3-phosphate dehydrogenase A gapA 0.0055
2799 Glyceraldehyde-3-phosphate dehydrogenase, glycosomal Not Available 0.0055
3367 GDP-mannose 6-dehydrogenase algD 0.0055
2683 Mono-ADP-ribosyltransferase C3 C3 0.0055
4318 Siroheme synthase cysG 0.0055
4343 Alpha-glucosidase aglA 0.0055
3296 Nicotinamide mononucleotide adenylyltransferase 1 NMNAT1 0.0055
711 UDP-glucose 6-dehydrogenase UGDH 0.0055
3672 UDP-glucose 6-dehydrogenase hasB 0.0055
4440 NADH peroxidase npr 0.0055
4504 WbpP Not Available 0.0055
63 Malate dehydrogenase mdh 0.0054
2329 Malate dehydrogenase mdh 0.0054
3445 Malate dehydrogenase mdh 0.0054
4420 Malate dehydrogenase mdh 0.0054
4438 Malate dehydrogenase mdh 0.0054
4476 Mannitol dehydrogenase mtlD 0.0054
597 Dihydropteridine reductase QDPR 0.0053
350 3-hydroxyacyl-CoA dehydrogenase type-2 HSD17B10 0.0053
178 NADH-cytochrome b5 reductase 3 CYB5R3 0.0053
328 Sorbitol dehydrogenase SORD 0.0053
396 Alcohol dehydrogenase 4 ADH4 0.0053
363 NADP-dependent malic enzyme, mitochondrial ME3 0.0053
812 Dihydrolipoyl dehydrogenase, mitochondrial DLD 0.0053
646 Malate dehydrogenase, cytoplasmic MDH1 0.0053
454 Peroxisomal multifunctional enzyme type 2 HSD17B4 0.0053
5591 Complement component C8 gamma chain C8G 0.0053
5598 Glycerol uptake operon antiterminator-related protein TM_1436 0.0053
5577 N5-carboxyaminoimidazole ribonucleotide mutase purE 0.0053
3792 KHG/KDPG aldolase [Includes: 4-hydroxy-2-oxoglutarate aldolase eda 0.0053
5582 Regulator of transcription; stringent starvation protein A sspA 0.0053
5587 Iron(III)-binding periplasmic protein fbpA 0.0053
2838 Ribose-5-phosphate isomerase A rpiA 0.0053
2952 Ribose-5-phosphate isomerase A rpiA 0.0053
5595 Ribose-5-phosphate isomerase A rpiA 0.0053
5590 N utilization substance protein B homolog nusB 0.0053
5593 Transferase Not Available 0.0053
5588 Cell division protein FtsY TM_0570 0.0053
5592 Ribonucleoside-diphosphate reductase subunit beta nrdF 0.0053
2300 Lysozyme E 0.0053
3633 Lysozyme R 0.0053
5597 Lysozyme 17 0.0053
5575 Short tail fiber protein 12 0.0053
5583 RNA 3'-terminal phosphate cyclase rtcA 0.0053
4238 50S ribosomal protein L4 rplD 0.0053
5578 50S ribosomal protein L4 rplD 0.0053
6173 50S ribosomal protein L4 rplD 0.0053
6219 50S ribosomal protein L4 rplD 0.0053
4695 UPF0124 protein yfiH yfiH 0.0053
5581 Beta-fructosidase bfrA 0.0053
5060 Intron-associated endonuclease 1 ITEVIR 0.0053
5600 Pyruvate decarboxylase pdc 0.0053
4375 Glutamine synthetase 1 glnA1 0.0053
5586 Pleckstrin homology domain-containing family A member 1 PLEKHA1 0.0053
5580 Hexon protein PII 0.0053
5574 Invasin YPTB1668 0.0053
3333 Nicotinamide mononucleotide adenylyltransferase 3 NMNAT3 0.0052
3070 Adenosylhomocysteinase AHCY 0.0052
4424 Adenosylhomocysteinase PFE1050w 0.0052
6278 Adenosylhomocysteinase ahcY 0.0052
2826 Glucose--fructose oxidoreductase gfo 0.0052
1799 Glucose-6-phosphate 1-dehydrogenase G6PD 0.0052
2630 Glucose-6-phosphate 1-dehydrogenase zwf 0.0052
5325 2,4-dienoyl-CoA reductase, mitochondrial DECR1 0.0052
3191 Histidinol dehydrogenase hisD 0.0052
2617 Nitric oxide synthase oxygenase nos 0.0052
2701 Nitric oxide synthase oxygenase nos 0.0052
2434 NH(3)-dependent NAD(+) synthetase nadE 0.0052
2910 NH(3)-dependent NAD(+) synthetase nadE 0.0052
3217 NH(3)-dependent NAD(+) synthetase nadE 0.0052
327 Glutathione reductase gor 0.0052
5110 Glutathione reductase GR2 0.0052
419 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial HADH 0.0051
77 L-lactate dehydrogenase B chain LDHB 0.0051
12 Alcohol dehydrogenase class 3 ADH5 0.0051
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.005
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.005
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.005
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.005
473 L-lactate dehydrogenase A chain LDHA 0.0049
794 Glyceraldehyde-3-phosphate dehydrogenase, testis-specific GAPDHS 0.0049
599 Glyceraldehyde-3-phosphate dehydrogenase GAPDH 0.0049
4426 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0049
4454 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0049
4489 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0049
4491 DNA ligase, NAD-dependent ligA 0.0048
2286 Isocitrate dehydrogenase [NADP] icd 0.0048
2302 Isocitrate dehydrogenase [NADP] icd 0.0048
2771 Isocitrate dehydrogenase [NADP] icd 0.0048
4992 Cytochrome c peroxidase Not Available 0.0047
166 NAD-dependent malic enzyme, mitochondrial ME2 0.0047
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0047
2762 UDP-glucose 4-epimerase GALE 0.0047
3461 UDP-glucose 4-epimerase galE 0.0047
3085 Molybdopterin-guanine dinucleotide biosynthesis protein A mobA 0.0047
5328 Prostaglandin F synthase Tb11.02.2310 0.0046
3132 Tryptophan synthase alpha chain trpA 0.0046
6568 Tryptophan synthase alpha chain trpA 0.0046
355 GMP synthase [glutamine-hydrolyzing] GMPS 0.0046
4353 GMP synthase [glutamine-hydrolyzing] guaA 0.0046
5006 RNASE4 protein RNASE4 0.0046
4533 Glyoxalase family protein BC_1747 0.0046
5599 3-carboxy-cis,cis-muconate cycloisomerase pcaB 0.0046
2555 Pol polyprotein pol 0.0046
3242 Pol polyprotein gag-pol 0.0046
3471 Pol polyprotein gag-pro-pol 0.0046
5256 Pol polyprotein pol 0.0046
6469 Pol polyprotein gag-pol 0.0046
6565 Pol polyprotein Not Available 0.0046
569 Retinal dehydrogenase 2 ALDH1A2 0.0045
611 Retinal dehydrogenase 1 ALDH1A1 0.0045
251 Alcohol dehydrogenase 1A ADH1A 0.0044
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0044
1467 Tumor necrosis factor ligand superfamily member 13B TNFSF13B 0.0043
2521 Cell division protein ftsZ ftsZ 0.0043
3301 Cell division protein ftsZ ftsZ 0.0043
4373 Medium-chain-fatty-acid--CoA ligase Not Available 0.0043
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0043
2149 Angiogenin ANG 0.0043
2603 Beta-lactamase II blm 0.0042
3583 6-phosphogluconolactonase pgl 0.0042
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0042
444 Alcohol dehydrogenase 1B ADH1B 0.0041
4366 Riboflavin kinase/FMN adenylyltransferase TM_0857 0.0041
2869 1-deoxy-D-xylulose 5-phosphate reductoisomerase dxr 0.004
2942 Sialidase nanH 0.004
3546 Sialidase nedA 0.004
857 Malate dehydrogenase, mitochondrial MDH2 0.004
3486 Fumarate hydratase class II fumC 0.004
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.004
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.004
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.004
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.004
714 Glutathione reductase, mitochondrial GSR 0.0039
2805 Heparan sulfate glucosamine 3-O-sulfotransferase 3A1 HS3ST3A1 0.0039
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0039
2697 Uridine-cytidine kinase 2 UCK2 0.0038
1123 Eosinophil cationic protein RNASE3 0.0038
332 Beta-lactamase blaZ 0.0037
2478 Beta-lactamase ampC 0.0037
2613 Beta-lactamase ampC 0.0037
2635 Beta-lactamase ampC 0.0037
2700 Beta-lactamase penP 0.0037
5445 Beta-lactamase blaB 0.0037
6019 Beta-lactamase SHV-7 0.0037
6701 Beta-lactamase cphA 0.0037
941 Betaine--homocysteine S-methyltransferase 1 BHMT 0.0037
2936 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0037
5184 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0037
2452 Tryptophanyl-tRNA synthetase trpS 0.0037
517 Alcohol dehydrogenase 1C ADH1C 0.0037
5579 Carboxypeptidase B CPB1 0.0035
3384 Macrophage migration inhibitory factor MIF 0.0034
411 Glycine N-methyltransferase GNMT 0.0034
128 Adenine phosphoribosyltransferase APRT 0.0032
5682 Ribonuclease pancreatic RNASE1 0.0027
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0027
822 Aldose reductase AKR1B1 0.0027
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0025
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.002
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