DT-Web: DB00987

Identification

Name

Cytarabine

Accession Number

DB00987 (APRD00499)

Type

small molecule

Description

A pyrimidine nucleoside analog that is used mainly in the treatment of leukemia, especially acute non-lymphoblastic leukemia. Cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. Its actions are specific for the S phase of the cell cycle. It also has antiviral and immunosuppressant properties. (From Martindale, The Extra Pharmacopoeia, 30th ed, p472)

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

243.2166

Groups

approved

Monoisotopic Weight

243.085520541

Pharmacology

Indication

For the treatment of acute non-lymphocytic leukemia, acute lymphocytic leukemia and blast phase of chronic myelocytic leukemia.

Mechanism of action

Cytarabine acts through direct DNA damage and incorporation into DNA. Cytarabine is cytotoxic to a wide variety of proliferating mammalian cells in culture. It exhibits cell phase specificity, primarily killing cells undergoing DNA synthesis (S-phase) and under certain conditions blocking the progression of cells from the G1 phase to the S-phase. Although the mechanism of action is not completely understood, it appears that cytarabine acts through the inhibition of DNA polymerase. A limited, but significant, incorporation of cytarabine into both DNA and RNA has also been reported.

Absorption

Less than 20% of the orally administered dose is absorbed from the gastrointestinal tract.

Protein binding

13%

Biotransformation

Hepatic.

Route of elimination

The primary route of elimination of cytarabine is metabolism to the inactive compound ara-U, followed by urinary excretion of ara-U.

Toxicity

Cytarabine syndrome may develop - it is characterized by fever, myalgia, bone pain, occasionally chest pain, maculopapular rash, conjunctivitis, and malaise.

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Digoxin	The antineoplasic agent decreases the effect of digoxin
Trastuzumab	Trastuzumab may increase the risk of neutropenia and anemia. Monitor closely for signs and symptoms of adverse events.

Food Interactions

Not Available

DNA
Name	DNA
Gene Name	Not Available
Pharmacological action	yes
Actions	cross-linking/alkylation
References	Prakasha Gowda AS, Polizzi JM, Eckert KA, Spratt TE: Incorporation of gemcitabine and cytarabine into DNA by DNA polymerase beta and ligase III/XRCC1. Biochemistry. 2010 Jun 15;49(23):4833-40. - Pubmed Foti M, Omichinski JG, Stahl S, Maloney D, West J, Schweitzer BI: Effects of nucleoside analog incorporation on DNA binding to the DNA binding domain of the GATA-1 erythroid transcription factor. FEBS Lett. 1999 Feb 5;444(1):47-53. - Pubmed
DTHybrid score	Not Available
DNA polymerase beta
Name	DNA polymerase beta
Gene Name	POLB
Pharmacological action	yes
Actions	inhibitor
References	Angeli JP, Ribeiro LR, Bellini MF, Mantovanil: Anti-clastogenic effect of beta-glucan extracted from barley towards chemically induced DNA damage in rodent cells. Hum Exp Toxicol. 2006 Jun;25(6):319-24. - Pubmed Miura S, Izuta S: DNA polymerases as targets of anticancer nucleosides. Curr Drug Targets. 2004 Feb;5(2):191-5. - Pubmed Krynetskaia NF, Phadke MS, Jadhav SH, Krynetskiy EY: Chromatin-associated proteins HMGB1/2 and PDIA3 trigger cellular response to chemotherapy-induced DNA damage. Mol Cancer Ther. 2009 Apr;8(4):864-72. - Pubmed
DTHybrid score	0.8983

Cytidine deaminase
Name	Cytidine deaminase
Gene Name	CDA
Actions	substrate
References	- Ohta T, Hori H, Ogawa M, Miyahara M, Kawasaki H, Taniguchi N, Komada Y: Impact of cytidine deaminase activity on intrinsic resistance to cytarabine in carcinoma cells. Oncol Rep. 2004 Nov;12(5):1115-20. - Pubmed Lamba JK: Genetic factors influencing cytarabine therapy. Pharmacogenomics. 2009 Oct;10(10):1657-74. - Pubmed
DTHybrid score	0.8424
Cytochrome P450 3A4
Name	Cytochrome P450 3A4
Gene Name	CYP3A4
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.3678
Deoxycytidine kinase
Name	Deoxycytidine kinase
Gene Name	DCK
Actions	substrate
References	Ohta T, Hori H, Ogawa M, Miyahara M, Kawasaki H, Taniguchi N, Komada Y: Impact of cytidine deaminase activity on intrinsic resistance to cytarabine in carcinoma cells. Oncol Rep. 2004 Nov;12(5):1115-20. - Pubmed Lamba JK: Genetic factors influencing cytarabine therapy. Pharmacogenomics. 2009 Oct;10(10):1657-74. - Pubmed
DTHybrid score	0.6945
5'-nucleotidase
Name	5'-nucleotidase
Gene Name	NT5E
Actions	substrate
References	Lamba JK: Genetic factors influencing cytarabine therapy. Pharmacogenomics. 2009 Oct;10(10):1657-74. - Pubmed
DTHybrid score	Not Available
Deoxycytidylate deaminase
Name	Deoxycytidylate deaminase
Gene Name	Not Available
Actions	substrate
References	Lamba JK: Genetic factors influencing cytarabine therapy. Pharmacogenomics. 2009 Oct;10(10):1657-74. - Pubmed
DTHybrid score	Not Available

Solute carrier family 22 member 2
Name	Solute carrier family 22 member 2
Gene Name	SLC22A2
Actions	substrate
References	Chen R, Nelson JA: Role of organic cation transporters in the renal secretion of nucleosides. Biochem Pharmacol. 2000 Jul 15;60(2):215-9. - Pubmed
DTHybrid score	0.3081
Solute carrier family 22 member 1
Name	Solute carrier family 22 member 1
Gene Name	SLC22A1
Actions	substrate
References	Chen R, Nelson JA: Role of organic cation transporters in the renal secretion of nucleosides. Biochem Pharmacol. 2000 Jul 15;60(2):215-9. - Pubmed
DTHybrid score	0.357
Multidrug resistance-associated protein 7
Name	Multidrug resistance-associated protein 7
Gene Name	ABCC10
Actions	substrate
References	Hopper-Borge E, Xu X, Shen T, Shi Z, Chen ZS, Kruh GD: Human multidrug resistance protein 7 (ABCC10) is a resistance factor for nucleoside analogues and epothilone B. Cancer Res. 2009 Jan 1;69(1):178-84. - Pubmed
DTHybrid score	0.2519
Equilibrative nucleoside transporter 1
Name	Equilibrative nucleoside transporter 1
Gene Name	SLC29A1
Actions	substrate
References	Santini D, Vincenzi B, Fratto ME, Perrone G, Lai R, Catalano V, Cass C, Ruffini PA, Spoto C, Muretto P, Rizzo S, Muda AO, Mackey JR, Russo A, Tonini G, Graziano F: Prognostic role of human equilibrative transporter 1 (hENT1) in patients with resected gastric cancer. J Cell Physiol. 2010 May;223(2):384-8. - Pubmed
DTHybrid score	0.4899

Id	Partner name	Gene Name	Score
3611	Cytidine deaminase	cdd	0.8424
3707	Cytidine deaminase	cdd	0.8424
1064	DNA (cytosine-5)-methyltransferase 1	DNMT1	0.204
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.1628
6171	Solute carrier family 28 member 3	SLC28A3	0.1593
1588	Multidrug resistance protein 1	ABCB1	0.1487
603	DNA polymerase alpha catalytic subunit	POLA1	0.1391
4119	Cytochrome P450 2D6	CYP2D6	0.1224
24	Thymidylate synthase	TMP1	0.1195
359	Thymidylate synthase	TYMS	0.1195
2626	Thymidylate synthase	thyA	0.1195
2729	Thymidylate synthase	thyA	0.1195
5352	Thymidylate synthase	THYA	0.1195
4200	Cytochrome P450 1A2	CYP1A2	0.1191
4118	Cytochrome P450 3A5	CYP3A5	0.1095
4757	Cytochrome P450 2C9	CYP2C9	0.1092
3690	Class B acid phosphatase precursor	aphA	0.0952
3299	DNA primase/helicase	4	0.0942
3755	Nucleoside-specific channel-forming protein tsx precursor	tsx	0.0893
3244	Ribonucleoside-diphosphate reductase 2 alpha subunit	nrdE	0.0875
2282	Protein recA	recA	0.0861
2315	Protein recA	recA	0.0861
2332	Protein recA	recA	0.0861
5263	Protein recA	recA	0.0861
6107	Cytochrome P450 3A7	CYP3A7	0.0837
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.0836
2633	Anaerobic ribonucleoside-triphosphate reductase	NRDD	0.0823
6016	Cytochrome P450 2C19	CYP2C19	0.0817
702	UMP-CMP kinase	CMPK1	0.0801
1729	Solute carrier family 22 member 6	SLC22A6	0.0767
6147	Solute carrier family 22 member 3	SLC22A3	0.075
16	Adenosine A1 receptor	ADORA1	0.0684
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0681
1178	Adenosine A2a receptor	ADORA2A	0.0663
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.0651
4924	Cytochrome P450 2C8	CYP2C8	0.0608
118	Organic cation/carnitine transporter 2	SLC22A5	0.0584
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0555
6142	Solute carrier family 22 member 8	SLC22A8	0.0552
862	Multidrug resistance-associated protein 1	ABCC1	0.0551
3639	Thymidine phosphorylase	deoA	0.0489
3936	Thymidine phosphorylase	TYMP	0.0489
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0487
833	Organic cation/carnitine transporter 1	SLC22A4	0.0475
6083	Deoxyguanosine kinase, mitochondrial	DGUOK	0.0461
6030	Cytochrome P450 2B6	CYP2B6	0.0458
2164	Multidrug resistance-associated protein 4	ABCC4	0.0458
776	Bile salt export pump	ABCB11	0.0449
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0434
1043	Trifunctional purine biosynthetic protein adenosine-3 [Includes: Phosphoribosylamine--glycine ligase	GART	0.0431
277	Purine nucleoside phosphorylase	PNP	0.0428
2870	Purine nucleoside phosphorylase	punA	0.0428
2945	Purine nucleoside phosphorylase	punA	0.0428
4659	Purine nucleoside phosphorylase	TM_1596	0.0428
4825	Purine nucleoside phosphorylase	TTHA1435	0.0428
6143	Solute carrier family 22 member 7	SLC22A7	0.0427
6013	Cytochrome P450 2E1	CYP2E1	0.0426
6024	Cytochrome P450 1A1	CYP1A1	0.0419
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.0396
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0386
587	Serum albumin	ALB	0.038
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.0352
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.035
365	Dihydrofolate reductase	DHFR	0.0306
2381	Dihydrofolate reductase	DFR1	0.0306
2833	Dihydrofolate reductase	Not Available	0.0306
2931	Dihydrofolate reductase	folA	0.0306
3544	Dihydrofolate reductase	folA	0.0306
3682	Dihydrofolate reductase	folA	0.0306
6642	Dihydrofolate reductase	folA	0.0306
6756	Dihydrofolate reductase	dfrA	0.0306
4604	Liver carboxylesterase 1	CES1	0.0303
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0287
766	Beta-2 adrenergic receptor	ADRB2	0.0285
1898	Cytochrome P450 1B1	CYP1B1	0.0284
6136	Multidrug resistance-associated protein 5	ABCC5	0.0281
556	Alpha-1A adrenergic receptor	ADRA1A	0.0269
1181	Alpha-1-acid glycoprotein 1	ORM1	0.0263
5718	Cytochrome P450 2A6	CYP2A6	0.0259
492	Histamine H1 receptor	HRH1	0.025
831	D(2) dopamine receptor	DRD2	0.0248
6031	Cytochrome P450 3A43	CYP3A43	0.0241
5626	Nucleoside diphosphate kinase B	NME2	0.0237
193	Beta-1 adrenergic receptor	ADRB1	0.0237
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0236
3947	Xanthine dehydrogenase/oxidase	XDH	0.0235
311	RNA-directed RNA polymerase catalytic subunit	PB1	0.0227
752	Large structural protein	L	0.0227
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0224
3957	Adenosine deaminase	ADA	0.0222
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0219
3811	Cytochrome P450 19A1	CYP19A1	0.0215
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0212
6137	Multidrug resistance-associated protein 6	ABCC6	0.0203
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.0201
378	Alpha-2C adrenergic receptor	ADRA2C	0.02
318	Alpha-2A adrenergic receptor	ADRA2A	0.0199
289	Cytosolic purine 5'-nucleotidase	NT5C2	0.0196
23	D(1A) dopamine receptor	DRD1	0.0196
5294	Nucleoside diphosphate kinase A	NME1	0.0195
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0192
632	Alpha-1B adrenergic receptor	ADRA1B	0.0192
6111	DNA polymerase epsilon subunit 4	POLE4	0.0189
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0189
6112	DNA polymerase epsilon subunit 3	POLE3	0.0189
6108	Ribonucleoside-diphosphate reductase subunit M2 B	RRM2B	0.0189
6110	DNA polymerase epsilon subunit 2	POLE2	0.0189
6109	DNA polymerase epsilon catalytic subunit A	POLE	0.0189
824	Sodium-dependent serotonin transporter	SLC6A4	0.0187
1024	Solute carrier family 22 member 11	SLC22A11	0.0185
3923	Cholinesterase	BCHE	0.0185
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0184
508	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	ENPP1	0.0179
629	Alpha-2B adrenergic receptor	ADRA2B	0.0179
20	Prostaglandin G/H synthase 1	PTGS1	0.0179
817	DNA topoisomerase 2-alpha	TOP2A	0.0177
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0176
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0174
136	Estrogen receptor	ESR1	0.017
124	Histamine H2 receptor	HRH2	0.017
474	Acetylcholinesterase	ACHE	0.0169
6020	Aldehyde oxidase	AOX1	0.0165
871	Glucocorticoid receptor	NR3C1	0.0163
677	Choline-phosphate cytidylyltransferase A	PCYT1A	0.0163
6106	Cytochrome P450 2C18	CYP2C18	0.016
6021	Adenosine kinase	ADK	0.0159
6010	Thiamine transporter 1	SLC19A2	0.0159
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0156
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0156
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0155
4218	Ribonucleoside-diphosphate reductase M2 subunit	RRM2	0.0151
789	Alpha-1D adrenergic receptor	ADRA1D	0.0151
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.015
342	P protein [Includes: DNA-directed DNA polymerase	P	0.0143
612	P protein [Includes: DNA-directed DNA polymerase	P	0.0143
175	Thiamin pyrophosphokinase 1	TPK1	0.0142
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0139
281	5'-AMP-activated protein kinase subunit beta-1	PRKAB1	0.0137
29	Tubulin beta-1 chain	TUBB1	0.0137
7	Nitric oxide synthase, inducible	NOS2	0.0136
731	HIV-1 protease	HIV-1 protease	0.0134
5923	Microtubule-associated protein tau	MAPT	0.0133
5924	Microtubule-associated protein 4	MAP4	0.0133
1852	Microtubule-associated protein 2	MAP2	0.0131
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.013
6141	Sodium/bile acid cotransporter	SLC10A1	0.0129
4192	DNA topoisomerase 2-beta	TOP2B	0.0127
87	Hypoxanthine-guanine phosphoribosyltransferase	HPRT1	0.0125
672	Prostaglandin F2-alpha receptor	PTGFR	0.0125
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0125
713	Sodium-dependent dopamine transporter	SLC6A3	0.0123
1405	Thiopurine S-methyltransferase	TPMT	0.0123
161	Tubulin beta chain	TUBB	0.012
312	Tubulin beta chain	TUB2	0.012
4209	ATP-sensitive inward rectifier potassium channel 8	KCNJ8	0.0116
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0116
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0114
273	Apoptosis regulator Bcl-2	BCL2	0.0114
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0112
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0112
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0112
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.011
4120	NADPH--cytochrome P450 reductase	POR	0.0108
756	Sex hormone-binding globulin	SHBG	0.0107
509	Thymidine kinase	TK	0.0106
570	Thymidine kinase	TK	0.0106
2559	Thymidine kinase	TK	0.0106
3430	Thymidine kinase	tdk	0.0106
3518	Thymidine kinase	TK	0.0106
5301	Thymidine kinase	tdk	0.0106
5771	Thymidine kinase	ORF36	0.0106
7009	Thymidine kinase	ORF36	0.0106
738	Monocarboxylate transporter 1	SLC16A1	0.0106
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0105
847	Mu-type opioid receptor	OPRM1	0.0102
3939	Amine oxidase [flavin-containing] B	MAOB	0.01
290	Prostaglandin G/H synthase 2	PTGS2	0.0097
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0096
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0095
4226	Uridine phosphorylase 2	UPP2	0.0094
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0094
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0094
4203	Histamine N-methyltransferase	HNMT	0.0094
908	Glutathione S-transferase theta-1	GSTT1	0.0093
2539	Tubulin alpha-1 chain	TUBA4A	0.0091
6070	Nischarin	NISCH	0.0089
638	D(3) dopamine receptor	DRD3	0.0089
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0088
467	Delta-type opioid receptor	OPRD1	0.0088
694	Matrix protein 2	M	0.0086
338	DNA polymerase	UL30	0.0086
379	DNA polymerase	UL54	0.0086
697	DNA polymerase	ORF28	0.0086
2482	DNA polymerase	43	0.0086
4104	DNA polymerase	BALF5	0.0086
4225	Uridine phosphorylase 1	UPP1	0.0085
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0084
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0084
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0083
869	Estrogen receptor beta	ESR2	0.0083
614	Progesterone receptor	PGR	0.0082
904	Glutathione S-transferase P	GSTP1	0.0082
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0081
2472	Voltage-gated potassium channel	kcsA	0.0081
6366	Voltage-gated potassium channel	kcsA	0.0081
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0081
432	D(4) dopamine receptor	DRD4	0.0081
232	Corticosteroid-binding globulin	SERPINA6	0.008
131	Synaptic vesicular amine transporter	SLC18A2	0.008
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0079
6167	Organic solute transporter subunit beta	OSTB	0.0078
6166	Organic solute transporter subunit alpha	OSTA	0.0078
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0078
413	Amidophosphoribosyltransferase	PPAT	0.0077
2515	Amidophosphoribosyltransferase	purF	0.0077
3714	Amidophosphoribosyltransferase	purF	0.0077
3704	Spermidine/putrescine-binding periplasmic protein precursor	potD	0.0077
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0077
477	DNA topoisomerase 4 subunit A	parC	0.0075
886	DNA topoisomerase 4 subunit A	parC	0.0075
6226	DNA topoisomerase 4 subunit A	parC	0.0075
696	Kappa-type opioid receptor	OPRK1	0.0074
404	DNA gyrase subunit A	gyrA	0.0074
6224	DNA gyrase subunit A	gyrA	0.0074
163	D(1B) dopamine receptor	DRD5	0.0073
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0072
828	Phenylalanine-4-hydroxylase	PAH	0.0072
3109	Phenylalanine-4-hydroxylase	phhA	0.0072
267	Plasminogen activator inhibitor 1	SERPINE1	0.007
260	Cytochrome P450 51	ERG11	0.0069
761	Cytochrome P450 51	ERG11	0.0069
3163	Cytochrome P450 51	cyp51	0.0069
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0069
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0067
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0067
3560	Gentamicin 3'-acetyltransferase	aacC1	0.0067
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0067
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.0067
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0067
749	Amiloride-sensitive cation channel 1, neuronal	ACCN1	0.0066
1341	Histamine H3 receptor	HRH3	0.0065
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0065
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0064
5126	Arginase	rocF	0.0064
164	Histamine H4 receptor	HRH4	0.0064
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0064
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0064
1770	Phospholipase C	PLCL1	0.0064
2841	Phospholipase C	plc	0.0064
465	Calmodulin	CALM1	0.0064
723	Cytosolic phospholipase A2	PLA2G4A	0.0063
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0063
3941	Amine oxidase [flavin-containing] A	MAOA	0.0063
6221	Steroid hormone receptor ERR1	ESRRA	0.0062
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0061
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0061
1517	Beta-3 adrenergic receptor	ADRB3	0.0061
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.006
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.006
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.006
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0059
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0059
387	Amiloride-sensitive amine oxidase [copper-containing]	ABP1	0.0059
7187	Amiloride-sensitive amine oxidase [copper-containing]	ABP1	0.0059
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0059
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0059
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0058
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0058
818	50S ribosomal protein L10	rplJ	0.0058
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0058
213	Amiloride-sensitive sodium channel subunit alpha	SCNN1A	0.0058
550	Amiloride-sensitive sodium channel subunit delta	SCNN1D	0.0058
827	Sodium/hydrogen exchanger 1	SLC9A1	0.0058
27	Amiloride-sensitive sodium channel subunit beta	SCNN1B	0.0058
552	Amiloride-sensitive sodium channel subunit gamma	SCNN1G	0.0058
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0058
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0058
740	Argininosuccinate synthase	ASS1	0.0058
865	Argininosuccinate synthase	ASS1	0.0058
2680	Argininosuccinate synthase	argG	0.0058
3194	Argininosuccinate synthase	argG	0.0058
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0056
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0055
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0055
504	Mast/stem cell growth factor receptor	KIT	0.0054
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0054
6085	Fatty acid-binding protein, intestinal	FABP2	0.0054
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0053
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0053
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0053
6014	Cytochrome P450 2A13	CYP2A13	0.0053
3809	Estrogen-related receptor gamma	ESRRG	0.0052
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0051
3587	Gastrotropin	FABP6	0.0051
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0051
624	Guanidinoacetate N-methyltransferase	GAMT	0.005
6146	High affinity copper uptake protein 1	SLC31A1	0.005
976	Platelet glycoprotein IX	GP9	0.005
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.005
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0049
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0049
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0049
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0049
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0049
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0049
6432	Transporter	snf	0.0049
6165	Copper-transporting ATPase 1	ATP7A	0.0049
6163	Copper-transporting ATPase 2	ATP7B	0.0049
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0049
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0048
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0048
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0047
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0047
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0047
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0047
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0047
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0046
896	Glutathione S-transferase Mu 1	GSTM1	0.0046
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0046
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0045
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0045
303	Diamine acetyltransferase 2	SAT2	0.0045
623	Spermine oxidase	SMOX	0.0045
1317	Spermine synthase	SMS	0.0045
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0045
737	Mineralocorticoid receptor	NR3C2	0.0045
33	Cystine/glutamate transporter	SLC7A11	0.0045
468	Cytochrome P450 4A11	CYP4A11	0.0045
5682	Ribonuclease pancreatic	RNASE1	0.0044
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0044
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0044
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0044
2449	Tubulin alpha-3 chain	TUBA1A	0.0043
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0043
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0043
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0043
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0043
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0043
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0043
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0043
5818	Folate receptor alpha	FOLR1	0.0042
6168	Solute carrier family 22 member 16	SLC22A16	0.0042
1757	Myeloperoxidase	MPO	0.0042
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0042
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0041
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0041
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0041
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0041
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0041
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.004
123	Diamine acetyltransferase 1	SAT1	0.004
153	Dopamine beta-hydroxylase	DBH	0.004
952	Dipeptidyl peptidase 4	DPP4	0.004
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.004
380	Cytochrome P450 17A1	CYP17A1	0.0039
1629	Transcription factor AP-1	JUN	0.0039
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0039
1129	C-C chemokine receptor type 5	CCR5	0.0039
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0038
146	Androgen receptor	AR	0.0038
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0038
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0038
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0037
293	Gamma-glutamyl hydrolase	GGH	0.0037
1864	RET proto-oncogene	RET	0.0036
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0036
527	Prostacyclin receptor	PTGIR	0.0036
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0036
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0036
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0036
2300	Lysozyme	E	0.0036
3633	Lysozyme	R	0.0036
5597	Lysozyme	17	0.0036
6182	Cytochrome P450 2J2	CYP2J2	0.0036
3929	Phosphoethanolamine/phosphocholine phosphatase	PHOSPHO1	0.0036
3926	Choline transporter-like protein 2	SLC44A2	0.0036
3933	Choline/ethanolaminephosphotransferase	CEPT1	0.0036
1686	Choline transporter-like protein 1	SLC44A1	0.0036
3927	Choline transporter-like protein 3	SLC44A3	0.0036
861	Choline kinase alpha	CHKA	0.0036
549	Choline-phosphate cytidylyltransferase B	PCYT1B	0.0036
3925	Choline transporter-like protein 4	SLC44A4	0.0036
264	Choline/ethanolamine kinase [Includes: Choline kinase beta	CHKB	0.0036
769	High-affinity choline transporter 1	SLC5A7	0.0036
700	Choline dehydrogenase, mitochondrial	CHDH	0.0036
576	Choline O-acetyltransferase	CHAT	0.0036
3922	Phospholipase D2	PLD2	0.0036
3924	Phospholipase D1	PLD1	0.0036
6211	Tubulin epsilon chain	TUBE1	0.0036
6212	Tubulin gamma-1 chain	TUBG1	0.0036
6210	Tubulin delta chain	TUBD1	0.0036
68	Cannabinoid receptor 1	CNR1	0.0036
1074	Urokinase-type plasminogen activator	PLAU	0.0036
122	P2Y purinoceptor 12	P2RY12	0.0035
856	Vitamin D3 receptor	VDR	0.0035
4237	50S ribosomal protein L22	rplV	0.0035
185	Vasopressin V1a receptor	AVPR1A	0.0035
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0035
939	50S ribosomal protein L3	rplC	0.0035
811	Translocator protein	TSPO	0.0035
322	Vasopressin V2 receptor	AVPR2	0.0034
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0034
1618	High affinity nerve growth factor receptor	NTRK1	0.0034
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.0033
6218	Pannexin-1	PANX1	0.0033
814	Ryanodine receptor 1	RYR1	0.0033
2251	Thymidylate kinase	tmk	0.0033
2254	Thymidylate kinase	DTYMK	0.0033
3522	Thymidylate kinase	tmk	0.0033
3478	Glucose-1-phosphate thymidylyltransferase	rmlA	0.0032
4277	Glucose-1-phosphate thymidylyltransferase	rmlA	0.0032
751	Potassium channel subfamily K member 6	KCNK6	0.0032
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0032
1650	Heme carrier protein 1	SLC46A1	0.0032
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0032
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0032
592	Carbonic anhydrase 4	CA4	0.0032
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0032
140	30S ribosomal protein S9	rpsI	0.0031
6719	30S ribosomal protein S9	rpsI	0.0031
6725	30S ribosomal protein S9	rpsI	0.0031
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0031
2257	Uridine phosphorylase	udp	0.0031
5132	Uridine phosphorylase	udp	0.0031
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0031
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0031
449	Ornithine decarboxylase	ODC1	0.0031
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0031
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0031
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0031
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0031
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0031
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0031
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0031
2578	Tubulin beta-3 chain	TUBB3	0.003
2285	Streptogramin A acetyltransferase	vatD	0.003
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.003
3810	Catechol O-methyltransferase	COMT	0.003
6043	Putative G-protein coupled receptor 44	GPR44	0.003
172	Potassium channel subfamily K member 1	KCNK1	0.003
716	5-hydroxytryptamine 7 receptor	HTR7	0.003
6149	Solute carrier family 22 member 10	SLC22A10	0.0029
284	DNA-directed RNA polymerase beta chain	rpoB	0.0029
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0029
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0029
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.0028
4217	Telomerase reverse transcriptase	TERT	0.0028
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0028
4173	Tyrosine-protein kinase JAK2	JAK2	0.0027
76	Nitric-oxide synthase, brain	NOS1	0.0027
295	Carbonic anhydrase 1	CA1	0.0027
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0027
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0027
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0026
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0026
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0026
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.0026
49	Endothelin B receptor	EDNRB	0.0026
407	Vascular endothelial growth factor receptor 2	KDR	0.0025
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0025
291	Nitric-oxide synthase, endothelial	NOS3	0.0025
5300	Antigen peptide transporter 1	TAP1	0.0025
768	FK506-binding protein 1A	FKBP1A	0.0025
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0024
705	Glutamate receptor 1	GRIA1	0.0024
578	Endothelin-1 receptor	EDNRA	0.0024
544	Potassium voltage-gated channel subfamily E member 1	KCNE1	0.0024
357	Carbonic anhydrase 2	CA2	0.0024
1483	Membrane copper amine oxidase	AOC3	0.0024
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0024
5852	Type-2 angiotensin II receptor	AGTR2	0.0024
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0024
642	3-oxo-5-alpha-steroid 4-dehydrogenase 2	SRD5A2	0.0023
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0023
844	Epidermal growth factor receptor	EGFR	0.0023
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0023
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0023
777	Tumor necrosis factor	TNF	0.0023
70	Type-1 angiotensin II receptor	AGTR1	0.0023
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0022
6220	Aryl hydrocarbon receptor	AHR	0.0022
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0022
2320	Thymidine kinase, cytosolic	TK1	0.0021
298	Renin	REN	0.0021
6506	Stathmin-4	STMN4	0.0021
1656	CYP2B protein	CYP2B	0.0021
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.0021
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0021
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0021
5287	Signaling protein	Not Available	0.0021
5288	Shikimate kinase	aroK	0.0021
5304	UPF0166 protein TM_0021	TM_0021	0.0021
5270	ATP-dependent Clp protease ATP-binding subunit clpX	clpX	0.0021
5314	UPF0079 ATP-binding protein HI0065	HI_0065	0.0021
5259	Transcriptional regulator	ntrC1	0.0021
6699	Transcriptional regulator	Cgl2612	0.0021
5290	ATP-dependent hsl protease ATP-binding subunit hslU	hslU	0.0021
5638	ATP-dependent hsl protease ATP-binding subunit hslU	hslU	0.0021
3199	Phosphopantetheine adenylyltransferase	coaD	0.0021
3543	Phosphopantetheine adenylyltransferase	coaD	0.0021
3567	Phosphopantetheine adenylyltransferase	coaD	0.0021
5289	Phosphopantetheine adenylyltransferase	coaD	0.0021
2874	Nitrogenase iron protein 1	nifH1	0.0021
4346	Polynucleotide kinase	pseT	0.0021
5293	Shikimate kinase 2	aroL	0.0021
5292	Putative partitioning protein	TT_C1605	0.0021
5281	Plasmid segregation protein parM	parM	0.0021
5305	Phosphoribosylaminoimidazole carboxylase ATPase subunit	purK	0.0021
5299	D-alanine--D-alanine ligase	ddl	0.0021
6598	D-alanine--D-alanine ligase	ddl	0.0021
5276	Chromosomal replication initiator protein dnaA	dnaA	0.0021
5266	Activator of	hgdC	0.0021
4794	Phosphoenolpyruvate carboxykinase [ATP]	pckA	0.0021
5283	D-alanine--D-alanine ligase B	ddlB	0.0021
5275	Multidrug resistance ABC transporter ATP-binding and permease protein	lmrA	0.0021
5308	Preprotein translocase secA 1 subunit	secA1	0.0021
5315	Chaperone protein htpG	htpG	0.0021
1549	Heat shock 70 kDa protein 1	HSPA1A	0.0021
5284	Large T antigen	Not Available	0.0021
3777	ATP-dependent Clp protease ATP-binding subunit clpA	clpA	0.0021
3982	Phosphoribosylformylglycinamidine synthase	PFAS	0.0021
5261	Phosphoribosylformylglycinamidine synthase	purL	0.0021
5277	Preprotein translocase subunit secA	secA	0.0021
5291	Glycogen synthase 1	glgA1	0.0021
5264	DNA replication protein	REP	0.0021
5285	Kinesin heavy chain	KIF5B	0.0021
489	Monocarboxylate transporter 2	SLC16A7	0.0021
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.002
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.002
633	Penicillin-binding proteins 1A/1B	pbpA	0.0019
373	Transthyretin	TTR	0.0019
3932	Glutathione S-transferase A2	GSTA2	0.0019
2499	Tubulin beta-2C chain	TUBB2C	0.0019
233	Potassium channel subfamily K member 2	KCNK2	0.0019
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0019
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0018
6102	Arylamine N-acetyltransferase 2	NAT2	0.0018
5998	Toll-like receptor 8	TLR8	0.0018
26	Vascular endothelial growth factor receptor 3	FLT4	0.0018
4238	50S ribosomal protein L4	rplD	0.0018
5578	50S ribosomal protein L4	rplD	0.0018
6173	50S ribosomal protein L4	rplD	0.0018
6219	50S ribosomal protein L4	rplD	0.0018
712	Tubulin alpha chain	TUB1	0.0018
1968	ATP-sensitive inward rectifier potassium channel 12	KCNJ12	0.0018
565	Extracellular calcium-sensing receptor	CASR	0.0018
683	Potassium transporter	GK0582	0.0018
2091	Endoplasmin	HSP90B1	0.0018
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0018
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0017
613	Atrial natriuretic peptide receptor A	NPR1	0.0017
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0017
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0017
32	Vascular endothelial growth factor receptor 1	FLT1	0.0017
543	Penicillin-binding protein 1B	mrcB	0.0017
6186	Penicillin-binding protein 1B	ponB	0.0017
6822	Penicillin-binding protein 1b	pbp1b	0.0017
6844	Penicillin-binding protein 1b	pbp1b	0.0017
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0017
1050	Bile salt sulfotransferase	SULT2A1	0.0017
159	Penicillin-binding protein 2B	penA	0.0017
6121	Penicillin-binding protein 2B	penA	0.0017
4106	Guanylate kinase	GUK1	0.0016
4516	Guanylate kinase	gmk	0.0016
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0016
6277	Heat shock cognate 71 kDa protein	HSPA8	0.0016
3390	Aminoglycoside 3'-phosphotransferase	aphA	0.0016
6029	Aminoglycoside 3'-phosphotransferase	aphA1	0.0016
4837	Cag-alfa	cag-alfa	0.0016
5646	Galactokinase	GALK1	0.0016
5302	TrwB	trwB	0.0016
4839	DNA polymerase III subunit tau	dnaX	0.0016
4774	NTPase P4	Not Available	0.0016
4838	PMS1 protein homolog 2	PMS2	0.0016
5265	FtsH	ftsH	0.0016
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0016
340	Apoptotic protease-activating factor 1	APAF1	0.0016
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0016
173	Toll-like receptor 7	TLR7	0.0016
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0016
2270	Dephospho-CoA kinase	coaE	0.0016
5189	Trimethylamine dehydrogenase	tmd	0.0016
2284	Adenylate kinase	adk	0.0016
2296	Adenylate kinase	adk	0.0016
2311	Adenylate kinase	adk	0.0016
2312	Adenylate kinase	Not Available	0.0016
3233	Bile acid receptor	NR1H4	0.0015
5295	2-keto-3-deoxy-gluconate kinase	TT_P0036	0.0015
2751	Holliday junction ATP-dependent DNA helicase ruvB	ruvB	0.0015
4755	Holliday junction ATP-dependent DNA helicase ruvB	ruvB	0.0015
3470	Hypothetical protein MG245 homolog	MPN_348	0.0015
6138	Multidrug resistance protein 3	ABCB4	0.0015
427	Substance-P receptor	TACR1	0.0015
3175	Glutamate--cysteine ligase	gshA	0.0015
3426	Glutamine synthetase	glnA	0.0015
3987	Glutamine synthetase	GLUL	0.0015
275	Arachidonate 5-lipoxygenase	ALOX5	0.0015
581	Cytochrome P450 2R1	CYP2R1	0.0015
2683	Mono-ADP-ribosyltransferase C3	C3	0.0015
2390	Nonsecretory ribonuclease	RNASE2	0.0014
1541	Metalloproteinase	mmp20	0.0014
5312	Kinesin-like protein KIF1A	KIF1A	0.0014
2922	Glycerol kinase	glpK	0.0014
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.0014
408	Riboflavin kinase	RFK	0.0014
1010	Cytochrome P450 51A1	CYP51A1	0.0014
5271	Focal adhesion kinase 1	PTK2	0.0013
1353	DNA topoisomerase 1	TOP1	0.0013
3552	DNA topoisomerase 1	topA	0.0013
4122	Histone deacetylase 2	HDAC2	0.0013
2615	Chemotaxis protein cheA	cheA	0.0013
5278	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1	PAPSS1	0.0013
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0013
6832	Serine/threonine-protein kinase SRPK2	SRPK2	0.0013
1881	Hexokinase-1	HK1	0.0013
2371	Pantothenate kinase	coaA	0.0013
891	Dihydropteroate synthase	folP	0.0013
5359	Dihydropteroate synthase	folP	0.0013
7175	Dihydropteroate synthase	sulI	0.0013
3669	Ribokinase	rbsK	0.0013
6116	Gastric triacylglycerol lipase	LIPF	0.0012
2950	Inositol-trisphosphate 3-kinase A	ITPKA	0.0012
780	Retinoic acid receptor RXR-gamma	RXRG	0.0012
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0012
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0012
3823	Cytokine receptor common gamma chain	IL2RG	0.0012
85	Growth hormone receptor	GHR	0.0012
6126	Carbonic anhydrase 7	CA7	0.0012
2892	Acetylglutamate kinase	argB	0.0012
3550	Acetylglutamate kinase	argB	0.0012
4366	Riboflavin kinase/FMN adenylyltransferase	TM_0857	0.0012
2107	Microtubule-associated protein 1A	MAP1A	0.0012
825	Arsenical pump-driving ATPase	ASNA1	0.0012
3435	Arsenical pump-driving ATPase	arsA	0.0012
571	Melatonin receptor type 1A	MTNR1A	0.0012
362	Melatonin receptor type 1B	MTNR1B	0.0012
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0012
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0012
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0012
1295	Fatty acid synthase	FASN	0.0012
2697	Uridine-cytidine kinase 2	UCK2	0.0012
6857	[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial	PDK2	0.0012
482	Glycine receptor subunit alpha-1	GLRA1	0.0012
2727	S-adenosylmethionine synthetase	metK	0.0012
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0012
201	Glutamate dehydrogenase 1, mitochondrial	GLUD1	0.0011
788	Creatine kinase M-type	CKM	0.0011
2817	Phosphoribosylglycinamide formyltransferase 2	purT	0.0011
239	Coagulation factor X	F10	0.0011
6390	Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	ATP2A1	0.0011
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0011
88	Retinoic acid receptor RXR-beta	RXRB	0.0011
921	Glutamate receptor 2	GRIA2	0.0011
453	S-adenosylmethionine synthetase isoform type-1	MAT1A	0.0011
754	Pancreatic triacylglycerol lipase	PNLIP	0.0011
48	Pyridoxal kinase	PDXK	0.0011
5787	Angiopoietin-1 receptor	TEK	0.0011
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0011
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0011
61	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK	0.0011
2644	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK	0.0011
2710	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK	0.0011
2178	Metabotropic glutamate receptor 5	GRM5	0.0011
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0011
724	Interleukin-2 receptor alpha chain	IL2RA	0.0011
717	Interleukin-2 receptor subunit beta	IL2RB	0.0011
54	Prothrombin	F2	0.001
207	Glutathione synthetase	GSS	0.001
5269	Glutathione synthetase	gshB	0.001
2334	Dethiobiotin synthetase	bioD	0.001
6555	Dethiobiotin synthetase	bioD	0.001
1810	Protein S100-A1	S100A1	0.001
6097	Protein S100-A2	S100A2	0.001
4116	Dihydropteroate synthetase	Not Available	0.001
4228	Keratin, type II cytoskeletal 7	KRT7	0.001
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.001
1144	Hepatocyte growth factor receptor	MET	0.001
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.001
493	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	0.001
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.001
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.001
512	DNA-directed RNA polymerase alpha chain	rpoA	0.001
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.001
4041	Microsomal glutathione S-transferase 2	MGST2	0.001
6824	Tyrosine-protein kinase Lyn	LYN	0.001
2511	MAP kinase-activated protein kinase 2	MAPKAPK2	0.001
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.001
605	Fumarate reductase flavoprotein subunit	frdA	0.001
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.001
3673	Fumarate reductase flavoprotein subunit	fccA	0.001
4912	Fumarate reductase flavoprotein subunit	ifcA	0.001
6549	Fumarate reductase flavoprotein subunit	frdA	0.001
2317	UDP-N-acetylmuramoylalanine--D-glutamate ligase	murD	0.001
6395	Myosin-14	MYH14	0.0009
2268	Cholesterol oxidase	choB	0.0009
2822	Cholesterol oxidase	choA	0.0009
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0009
6105	3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	0.0009
1422	Serine/threonine-protein kinase 6	AURKA	0.0009
3086	Plasmepsin-2	Not Available	0.0009
459	Retinoic acid receptor RXR-alpha	RXRA	0.0009
165	FL cytokine receptor	FLT3	0.0009
1048	Protein S100-A13	S100A13	0.0009
2226	Protein S100-A12	S100A12	0.0009
1648	Elastin	ELN	0.0009
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0009
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0009
6131	Carbonic anhydrase 14	CA14	0.0009
2283	Steroid Delta-isomerase	ksi	0.0009
2920	Steroid Delta-isomerase	ksi	0.0009
3379	Kinesin-like protein KIF11	KIF11	0.0009
183	Vascular endothelial growth factor A	VEGFA	0.0009
3456	Heat shock protein HSP 90-beta	HSP90AB1	0.0009
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0009
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0009
390	Adenosine A3 receptor	ADORA3	0.0009
3822	Actin, alpha skeletal muscle	ACTA1	0.0009
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0009
2132	Protein S100-B	S100B	0.0009
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0008
3404	Exotoxin A	eta	0.0008
22	30S ribosomal protein S4	rpsD	0.0008
6714	30S ribosomal protein S4	rpsD	0.0008
6122	Carbonic anhydrase 3	CA3	0.0008
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0008
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0008
94	5-hydroxytryptamine 4 receptor	HTR4	0.0008
1867	Major prion protein	PRNP	0.0008
1721	Glycogen synthase kinase-3 beta	GSK3B	0.0008
2232	Interleukin-5	IL5	0.0008
1593	Mucin-2	MUC2	0.0008
4031	Glutathione S-transferase A1	GSTA1	0.0008
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0008
1649	Small inducible cytokine A2	CCL2	0.0008
1025	Aquaporin-1	AQP1	0.0008
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0008
3856	Fibroblast growth factor receptor 3	FGFR3	0.0008
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0008
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.0007
473	L-lactate dehydrogenase A chain	LDHA	0.0007
461	Glycine receptor subunit alpha-3	GLRA3	0.0007
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0007
130	Prostacyclin synthase	PTGIS	0.0007
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0007
6103	Arylamine N-acetyltransferase 1	NAT1	0.0007
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.0007
2112	Toll-like receptor 9	TLR9	0.0007
6207	30S ribosomal protein S14	rpsN	0.0007
6209	30S ribosomal protein S19	rpsS	0.0007
6712	30S ribosomal protein S19	rpsS	0.0007
6726	30S ribosomal protein S19	rpsS	0.0007
469	Annexin A1	ANXA1	0.0007
645	Penicillin-binding protein 1A	mrcA	0.0007
5805	Penicillin-binding protein 1A	ponA	0.0007
6185	Penicillin-binding protein 1A	mrcA	0.0007
6799	Penicillin-binding protein 1A	pbpA	0.0007
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0007
2298	Cytochrome P450-cam	camC	0.0007
518	Peroxidase/catalase T	katG	0.0007
2290	ADP-ribosyl cyclase 2	BST1	0.0007
226	Gonadotropin-releasing hormone receptor	GNRHR	0.0007
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0007
4311	tRNA	TRDMT1	0.0007
4325	tRNA	trmD	0.0007
4328	tRNA	trmD	0.0007
1123	Eosinophil cationic protein	RNASE3	0.0007
2599	Tyrosine-protein kinase HCK	HCK	0.0007
3937	Fatty-acid amide hydrolase	FAAH	0.0006
144	Hemoglobin subunit alpha	HBA1	0.0006
106	Cannabinoid receptor 2	CNR2	0.0006
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0006
6174	50S ribosomal protein L32	rpmF	0.0006
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0006
1196	Complement decay-accelerating factor	CD55	0.0006
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0006
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0006
563	Thyroid peroxidase	TPO	0.0006
936	Ephrin type-A receptor 2	EPHA2	0.0006
1291	cAMP response element-binding protein	CREB1	0.0006
1569	G1/S-specific cyclin-D1	CCND1	0.0006
1525	Heparin-binding growth factor 2	FGF2	0.0006
634	Squalene monooxygenase	SQLE	0.0006
7196	Squalene monooxygenase	ERG1	0.0006
4210	Toll-like receptor 4	TLR4	0.0005
2808	Chloramphenicol acetyltransferase 3	cat3	0.0005
84	Nuclear receptor 0B1	NR0B1	0.0005
1760	Aminopeptidase N	ANPEP	0.0005
6843	Aminopeptidase N	pepN	0.0005
1262	Corticotropin-lipotropin	POMC	0.0005
1192	Sulfotransferase 1A1	SULT1A1	0.0005
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0005
117	Sterol O-acyltransferase 1	SOAT1	0.0005
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0005
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0005
244	Angiotensin-converting enzyme	ACE	0.0005
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0005
823	Fibroblast growth factor receptor 2	FGFR2	0.0005
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0005
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0005
2417	Chloramphenicol acetyltransferase	cat	0.0005
3278	Chloramphenicol acetyltransferase	cat	0.0005
2810	Dr hemagglutinin structural subunit	draA	0.0005
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0005
3601	Dihydropteroate synthase 1	folP1	0.0005
3807	Dihydropteroate synthase 1	folP1	0.0005
3808	Dihydropteroate synthase 2	folP2	0.0005
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0005
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0005
1714	Mitogen-activated protein kinase 3	MAPK3	0.0005
2236	Casein kinase II subunit alpha	CSNK2A1	0.0005
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0005
3913	Glutamic acid decarboxylase	GAD65	0.0005
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0004
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0004
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0004
1992	Vitamin D-binding protein	GC	0.0004
319	Opioid receptor, sigma 1	OPRS1	0.0004
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0004
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0004
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0004
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0004
4103	Proteasome subunit beta type 2	PSMB2	0.0004
4101	Proteasome subunit beta type 1	PSMB1	0.0004
4102	Proteasome subunit beta type 5	PSMB5	0.0004
1630	Integrin beta-2	ITGB2	0.0004
1374	Natriuretic peptides B	NPPB	0.0004
1827	Gap junction alpha-1 protein	GJA1	0.0004
1908	Vascular cell adhesion protein 1	VCAM1	0.0004
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0004
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0004
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0004
2216	Fibroblast growth factor receptor 4	FGFR4	0.0004
735	Alanine aminotransferase 1	GPT	0.0004
3904	Alanine aminotransferase 2	GPT2	0.0004
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0004
1176	Mitogen-activated protein kinase 1	MAPK1	0.0004
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0004
251	Alcohol dehydrogenase 1A	ADH1A	0.0004
174	Sigma 1-type opioid receptor	SIGMAR1	0.0004
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0004
594	Thyroxine-binding globulin	SERPINA7	0.0004
6048	Troponin C, skeletal muscle	TNNC2	0.0004
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0004
719	Retinoic acid receptor responder protein 1	RARRES1	0.0003
770	Retinoic acid-induced protein 3	GPRC5A	0.0003
820	Glycine receptor subunit alpha-2	GLRA2	0.0003
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0003
268	Adenosine A2b receptor	ADORA2B	0.0003
6044	Serum paraoxonase/lactonase 3	PON3	0.0003
758	Thyroid hormone receptor alpha	THRA	0.0003
444	Alcohol dehydrogenase 1B	ADH1B	0.0003
484	Tyrosine-protein kinase ABL2	ABL2	0.0003
2240	Cell division protein kinase 2	CDK2	0.0003
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0003
572	Integrin alpha-L	ITGAL	0.0003
5798	Mitogen-activated protein kinase 11	MAPK11	0.0003
199	Monocarboxylate transporter 8	SLC16A2	0.0003
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0003
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0003
569	Retinal dehydrogenase 2	ALDH1A2	0.0003
346	Thyroid hormone receptor beta-1	THRB	0.0003
1275	Estrogen sulfotransferase	SULT1E1	0.0003
611	Retinal dehydrogenase 1	ALDH1A1	0.0003
760	Fibroblast growth factor 1	FGF1	0.0003
517	Alcohol dehydrogenase 1C	ADH1C	0.0003
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0003
1268	Neuropeptide S receptor	NPSR1	0.0003
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0003
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0003
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0003
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0003
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0003
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0003
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0003
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0003
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0003
5934	Cytochrome P450 26A1	CYP26A1	0.0003
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0003
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0003
1039	Histone deacetylase 9	HDAC9	0.0003
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0003
6073	Potassium channel subfamily K member 9	KCNK9	0.0003
6072	Potassium channel subfamily K member 3	KCNK3	0.0003
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0002
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0002
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0002
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0002
162	Retinoic acid receptor gamma-1	RARG	0.0002
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0002
6135	Sodium channel subunit beta-4	SCN4B	0.0002
6134	Sodium channel subunit beta-3	SCN3B	0.0002
6132	Sodium channel subunit beta-1	SCN1B	0.0002
6127	Carbonic anhydrase-related protein	CA8	0.0002
6128	Carbonic anhydrase-related protein 10	CA10	0.0002
6133	Sodium channel subunit beta-2	SCN2B	0.0002
6129	Carbonic anhydrase-related protein 11	CA11	0.0002
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0002
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0002
6130	Carbonic anhydrase 13	CA13	0.0002
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0002
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0002
2207	Rhodopsin	RHO	0.0002
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0002
3007	Carbonic anhydrase 12	CA12	0.0002
4205	Carbonic anhydrase 9	CA9	0.0002
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0001
4936	Cytochrome c2 iso-2	Not Available	0.0001
4916	Cyanoglobin	glbN	0.0001
4994	Hemoglobin-like protein HbO	glbO	0.0001
4915	Cytochrome c-550	psbV	0.0001
4959	Cytochrome c-550	psbV	0.0001
5216	Cytochrome c-550	psbV	0.0001
4925	Cytochrome c-type protein SHP	shp	0.0001
4904	Cytochrome c family protein	GSU1996	0.0001
4943	Cytochrome c6	petJ	0.0001
3116	Bacterioferritin	bfr	0.0001
4906	Bacterioferritin	bfr	0.0001
4965	Bacterioferritin	bfr	0.0001
4954	Soluble cytochrome b558	Not Available	0.0001
4934	Cytochrome c-551	nirM	0.0001
5218	Cytochrome c-551	nirM	0.0001
4905	Cytochrome c2	Not Available	0.0001
4939	Cytochrome c2	cycA	0.0001
4964	Cytochrome c2	cycA	0.0001
4979	Cytochrome c2	cycA	0.0001
6673	Cytochrome c2	cycA	0.0001
4910	Cytoglobin	CYGB	0.0001
4984	Neuroglobin	NGB	0.0001
4981	Iron-starvation protein PigA	pigA	0.0001
4909	CooA protein	cooA	0.0001
4998	Hemoglobin-like protein yjbI	yjbI	0.0001
4935	Cytochrome c-554	cycA1	0.0001
4947	Bacterial hemoglobin	vhb	0.0001
4975	Cytochrome c-556	RPA3973	0.0001
4942	Diheme cytochrome c napB	napB	0.0001
4931	Cytochrome P450 167A1	CYP167A1	0.0001
5000	HemO	hemO	0.0001
4972	P450cin	cinA	0.0001
4960	Putative cytochrome P450-family protein	SCO7417	0.0001
4971	Nonaheme cytochrome c	hmcA	0.0001
4989	Cytochrome c551 peroxidase	ccp	0.0001
5222	Cytochrome c551 peroxidase	ccpA	0.0001
4961	Hemophore HasA	hasA	0.0001
4976	Apocytochrome f	petA	0.0001
6407	Apocytochrome f	petA	0.0001
4907	Cytochrome c-L	moxG	0.0001
6865	Cytochrome c-L	moxG	0.0001
4993	Hydroxylamine oxidoreductase	hao1	0.0001
4764	Cytochrome P450 165C4	CYP165C4	0.0001
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0001
644	Heme oxygenase 2	HMOX2	0.0001
4982	Heme oxygenase 2	pbsA2	0.0001
4952	Catalase/peroxidase	katA	0.0001
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0001
4937	Cytochrome oxidase subunit II	rcoxA	0.0001
4903	Methyl-accepting chemotaxis protein	Tar4	0.0001
4999	Cytochrome P450 165B3	CYP165B3	0.0001
3093	Catalase HPII	katE	0.0001
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0001
4922	Cytochrome c, putative	SO_4144	0.0001
4920	Peroxidase/catalase	katG	0.0001
4990	PpcA	ppcA	0.0001
4948	Cytochrome c-553	Not Available	0.0001
4923	Cytochrome c3	DvMF_2499	0.0001
4945	Cytochrome c3	Not Available	0.0001
4949	Cytochrome c3	DVU_3171	0.0001
4968	Cytochrome c3	cytc3	0.0001
4997	Cytochrome c3	SO_2727	0.0001
5219	Cytochrome c3	cyd	0.0001
2119	Cytochrome b5	CYB5A	0.0001
4902	Nine-heme cytochrome c	Ddes_2038	0.0001
3189	High-molecular-weight cytochrome c	hmcA	0.0001
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0001
3375	Acidic cytochrome c3	Not Available	0.0001
4988	Sulfite oxidase, mitochondrial	SUOX	0.0001
2915	Sensor protein fixL	fixL	0.0001
4944	Sensor protein fixL	fixL	0.0001
4813	Heme oxygenase	hmuO	0.0001
5769	Heme oxygenase	Not Available	0.0001
3570	Cytochrome P450 152A1	cypC	0.0001
4385	Cytochrome c'	Not Available	0.0001
4967	Cytochrome c'	cycA	0.0001
5038	Cytochrome c'	Not Available	0.0001
5223	Cytochrome c'	cycP	0.0001
4037	Hypothetical protein	GPX1	0.0001
4297	Hypothetical protein	SP_1951	0.0001
4521	Hypothetical protein	BC_2969	0.0001
4540	Hypothetical protein	TM_1070	0.0001
4555	Hypothetical protein	MT1739	0.0001
4569	Hypothetical protein	mshD	0.0001
4578	Hypothetical protein	PA3270	0.0001
4747	Hypothetical protein	PA3967	0.0001
5177	Hypothetical protein	TM_0096	0.0001
5194	Hypothetical protein	PA1204	0.0001
5240	Hypothetical protein	Rv2991	0.0001
5370	Hypothetical protein	TM_1158	0.0001
5710	Hypothetical protein	Tb927.5.1360	0.0001
4289	Cytochrome P450	TT_P0059	0.0001
6262	Cytochrome P450	staP	0.0001
4992	Cytochrome c peroxidase	Not Available	0.0001
2230	Catalase	CAT	0.0001
3249	Catalase	katA	0.0001
3625	Catalase	katA	0.0001
4539	Catalase	katA	0.0001
4941	Catalase	katB	0.0001
3670	Soluble cytochrome b562 precursor	cybC	0.0001
3411	Cytochrome P450 121	cyp121	0.0001
3291	Cytochrome c-552	cycA	0.0001
4927	Cytochrome c-552	nrfA	0.0001
4938	Cytochrome c-552	cycA	0.0001
4953	Cytochrome c-552	nrfA	0.0001
5217	Cytochrome c-552	cycM	0.0001
2617	Nitric oxide synthase oxygenase	nos	0.0001
2701	Nitric oxide synthase oxygenase	nos	0.0001
3102	Flavohemoprotein	hmp	0.0001
4969	Flavohemoprotein	hmp	0.0001
4386	Hemoglobin-like protein HbN	glbN	0.0001
3127	Nitrite reductase	nirS	0.0001
3284	Nitrite reductase	nirS	0.0001
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0001
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0001
3221	Cytochrome c4	cc4	0.0001
4608	Putative cytochrome P450	SCO1207	0.0001
4963	Putative cytochrome P450	SCO2884	0.0001
6254	Putative cytochrome P450	SCO6998	0.0001
358	Cystathionine beta-synthase	CBS	0
1507	Cytochrome c	CYCS	0
693	Hemoglobin subunit beta	HBB	0
6268	Hydroxyacid oxidase 1	HAO1	0
810	Heme oxygenase 1	HMOX1	0
3391	Heme oxygenase 1	pbsA1	0

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB00987 - Cytarabine

Targets

Enzymes

Transporters

Predictions