DT-Web: DB00943

Identification

Name

Zalcitabine

Accession Number

DB00943 (APRD00562)

Type

small molecule

Description

A dideoxynucleoside compound in which the 3'-hydroxyl group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of 5' to 3' phosphodiester linkages, which are needed for the elongation of DNA chains, thus resulting in the termination of viral DNA growth. The compound is a potent inhibitor of HIV replication at low concentrations, acting as a chain-terminator of viral DNA by binding to reverse transcriptase. Its principal toxic side effect is axonal degeneration resulting in peripheral neuropathy. [PubChem]

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

211.2178

Groups

approved

Monoisotopic Weight

211.095691297

Pharmacology

Indication

For the treatment of Human immunovirus (HIV) infections in conjunction with other antivirals.

Mechanism of action

Zalcitabine is a nucleoside reverse transcriptase inhibitor (NRTI) with activity against Human Immunodeficiency Virus Type 1 (HIV-1). Within cells, zalcitabine is converted to its active metabolite, dideoxycytidine 5'-triphosphate (ddCTP), by the sequential action of cellular enzymes. ddCTP interferes with viral RNA-directed DNA polymerase (reverse transcriptase) by competing for utilization of the natural substrate deoxycytidine 5'-triphosphate (dCTP), as well as incorpating into viral DNA. Due to it's lack of a 3'-OH group, the formation of a 5' to 3' phosphodiester linkage that is necessary for DNA chain elongation is inhibited, thus leading to the termination of viral DNA growth.

Absorption

Bioavailability is over 80% following oral administration.

Protein binding

Less than 4%

Biotransformation

Hepatic

Route of elimination

Renal excretion of unchanged drug appears to be the primary route of elimination, accounting for approximately 80% of an intravenous dose and 60% of an orally administered dose within 24 hours after dosing (n=19). Renal clearance exceeds glomerular filtration rate suggesting renal tubular secretion contributes to the elimination of zalcitabine by the kidneys.

Toxicity

Acute overdose: Inadvertent pediatric overdoses have occurred with doses up to 1.5 mg/kg zalcitabine. Chronic overdose: in an initial dose-finding study in which zalcitabine was administered at doses 25 times (0.25 mg/kg every 8 hours) the currently recommended dose, one patient discontinued zalcitabine after 1 1/2 weeks of treatment subsequent to the development of a rash and fever.

Affected organisms

Human Immunodeficiency Virus

Interactions

Drug Interactions

Drug	Mechanism of interaction
Didanosine	Additive toxicities (peripheral neuropathy)
Lamivudine	Lamivudine may reduce the efficacy of zalcitabine. Combination therapy is not recommended.
Pentamidine	Additive risk of pancreatitis. Concomitant therapy should be avoided.
Ribavirin	Ribavirin may increase the hepatotoxicity of zalcitabine. May cause lactic acidosis. MOnitor for lactic acidosis during concomitant therapy.

Food Interactions

Do not take calcium, aluminium, magnesium or iron supplements within 2 hours of taking this medication.
Take on empty stomach: 1 hour before or 2 hours after meals.

Reverse transcriptase
Name	Reverse transcriptase
Gene Name	Not Available
Pharmacological action	yes
Actions	inhibitor
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Barry M, Gibbons S, Back D, Mulcahy F: Protease inhibitors in patients with HIV disease. Clinically important pharmacokinetic considerations. Clin Pharmacokinet. 1997 Mar;32(3):194-209. - Pubmed
DTHybrid score	Not Available

Deoxycytidine kinase
Name	Deoxycytidine kinase
Gene Name	DCK
Actions	substrate
References	- Rossi L, Serafini S, Schiavano GF, Casabianca A, Vallanti G, Chiarantini L, Magnani M: Metabolism, mitochondrial uptake and toxicity of 2', 3'-dideoxycytidine. Biochem J. 1999 Dec 15;344 Pt 3:915-20. - Pubmed Kitos TE, Tyrrell DL: Intracellular metabolism of 2',3'-dideoxynucleosides in duck hepatocyte primary cultures. Biochem Pharmacol. 1995 May 11;49(9):1291-302. - Pubmed
DTHybrid score	0.5474
Cytochrome P450 2C9
Name	Cytochrome P450 2C9
Gene Name	CYP2C9
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.4199
Cytochrome P450 2D6
Name	Cytochrome P450 2D6
Gene Name	CYP2D6
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.4498
Cytochrome P450 3A4
Name	Cytochrome P450 3A4
Gene Name	CYP3A4
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.6697
Cytochrome P450 3A43
Name	Cytochrome P450 3A43
Gene Name	CYP3A43
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.1822
Cytochrome P450 3A5
Name	Cytochrome P450 3A5
Gene Name	CYP3A5
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.4442
Cytochrome P450 3A7
Name	Cytochrome P450 3A7
Gene Name	CYP3A7
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.3702

Solute carrier family 22 member 6
Name	Solute carrier family 22 member 6
Gene Name	SLC22A6
Actions	substrate
References	Wada S, Tsuda M, Sekine T, Cha SH, Kimura M, Kanai Y, Endou H: Rat multispecific organic anion transporter 1 (rOAT1) transports zidovudine, acyclovir, and other antiviral nucleoside analogs. J Pharmacol Exp Ther. 2000 Sep;294(3):844-9. - Pubmed
DTHybrid score	0.3578
Solute carrier family 22 member 7
Name	Solute carrier family 22 member 7
Gene Name	SLC22A7
Actions	substrate
References	Morita N, Kusuhara H, Sekine T, Endou H, Sugiyama Y: Functional characterization of rat organic anion transporter 2 in LLC-PK1 cells. J Pharmacol Exp Ther. 2001 Sep;298(3):1179-84. - Pubmed
DTHybrid score	0.2037
Equilibrative nucleoside transporter 1
Name	Equilibrative nucleoside transporter 1
Gene Name	SLC29A1
Actions	Not Available
References	Yao SY, Ng AM, Sundaram M, Cass CE, Baldwin SA, Young JD: Transport of antiviral 3'-deoxy-nucleoside drugs by recombinant human and rat equilibrative, nitrobenzylthioinosine (NBMPR)-insensitive (ENT2) nucleoside transporter proteins produced in Xenopus oocytes. Mol Membr Biol. 2001 Apr-Jun;18(2):161-7. - Pubmed
DTHybrid score	0.3628
Equilibrative nucleoside transporter 2
Name	Equilibrative nucleoside transporter 2
Gene Name	Not Available
Actions	Not Available
References	Yao SY, Ng AM, Sundaram M, Cass CE, Baldwin SA, Young JD: Transport of antiviral 3'-deoxy-nucleoside drugs by recombinant human and rat equilibrative, nitrobenzylthioinosine (NBMPR)-insensitive (ENT2) nucleoside transporter proteins produced in Xenopus oocytes. Mol Membr Biol. 2001 Apr-Jun;18(2):161-7. - Pubmed
DTHybrid score	Not Available

Id	Partner name	Gene Name	Score
6016	Cytochrome P450 2C19	CYP2C19	0.2781
1588	Multidrug resistance protein 1	ABCB1	0.2651
4924	Cytochrome P450 2C8	CYP2C8	0.2435
4200	Cytochrome P450 1A2	CYP1A2	0.2253
6142	Solute carrier family 22 member 8	SLC22A8	0.1453
6030	Cytochrome P450 2B6	CYP2B6	0.1385
603	DNA polymerase alpha catalytic subunit	POLA1	0.1348
6013	Cytochrome P450 2E1	CYP2E1	0.1298
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.1243
6171	Solute carrier family 28 member 3	SLC28A3	0.1152
587	Serum albumin	ALB	0.1145
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.1077
1024	Solute carrier family 22 member 11	SLC22A11	0.1005
3690	Class B acid phosphatase precursor	aphA	0.0952
20	Prostaglandin G/H synthase 1	PTGS1	0.0951
6024	Cytochrome P450 1A1	CYP1A1	0.0946
5718	Cytochrome P450 2A6	CYP2A6	0.0936
3755	Nucleoside-specific channel-forming protein tsx precursor	tsx	0.085
6145	Solute carrier family 22 member 1	SLC22A1	0.0824
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.0795
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.0761
862	Multidrug resistance-associated protein 1	ABCC1	0.0722
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.0703
6144	Solute carrier family 22 member 2	SLC22A2	0.0697
24	Thymidylate synthase	TMP1	0.067
359	Thymidylate synthase	TYMS	0.067
2626	Thymidylate synthase	thyA	0.067
2729	Thymidylate synthase	thyA	0.067
5352	Thymidylate synthase	THYA	0.067
290	Prostaglandin G/H synthase 2	PTGS2	0.065
1064	DNA (cytosine-5)-methyltransferase 1	DNMT1	0.0645
2164	Multidrug resistance-associated protein 4	ABCC4	0.0642
492	Histamine H1 receptor	HRH1	0.0641
6148	Multidrug resistance-associated protein 7	ABCC10	0.0625
3611	Cytidine deaminase	cdd	0.0611
3707	Cytidine deaminase	cdd	0.0611
4211	Cytidine deaminase	CDA	0.0611
6106	Cytochrome P450 2C18	CYP2C18	0.0564
776	Bile salt export pump	ABCB11	0.0513
824	Sodium-dependent serotonin transporter	SLC6A4	0.0504
1181	Alpha-1-acid glycoprotein 1	ORM1	0.0486
118	Organic cation/carnitine transporter 2	SLC22A5	0.0468
6083	Deoxyguanosine kinase, mitochondrial	DGUOK	0.0461
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0453
847	Mu-type opioid receptor	OPRM1	0.0445
277	Purine nucleoside phosphorylase	PNP	0.0444
2870	Purine nucleoside phosphorylase	punA	0.0444
2945	Purine nucleoside phosphorylase	punA	0.0444
4659	Purine nucleoside phosphorylase	TM_1596	0.0444
4825	Purine nucleoside phosphorylase	TTHA1435	0.0444
6136	Multidrug resistance-associated protein 5	ABCC5	0.0444
1043	Trifunctional purine biosynthetic protein adenosine-3 [Includes: Phosphoribosylamine--glycine ligase	GART	0.0431
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0429
3811	Cytochrome P450 19A1	CYP19A1	0.0428
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0425
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0419
831	D(2) dopamine receptor	DRD2	0.0418
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0416
1898	Cytochrome P450 1B1	CYP1B1	0.0416
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0408
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.0407
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.0387
702	UMP-CMP kinase	CMPK1	0.0378
556	Alpha-1A adrenergic receptor	ADRA1A	0.0373
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0356
365	Dihydrofolate reductase	DHFR	0.0351
2381	Dihydrofolate reductase	DFR1	0.0351
2833	Dihydrofolate reductase	Not Available	0.0351
2931	Dihydrofolate reductase	folA	0.0351
3544	Dihydrofolate reductase	folA	0.0351
3682	Dihydrofolate reductase	folA	0.0351
6642	Dihydrofolate reductase	folA	0.0351
6756	Dihydrofolate reductase	dfrA	0.0351
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0348
1830	5'-nucleotidase	NT5E	0.0345
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0337
125	DNA polymerase beta	POLB	0.0322
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0322
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0321
871	Glucocorticoid receptor	NR3C1	0.032
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0318
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0318
467	Delta-type opioid receptor	OPRD1	0.0316
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0316
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0315
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0312
766	Beta-2 adrenergic receptor	ADRB2	0.0311
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0311
6147	Solute carrier family 22 member 3	SLC22A3	0.0302
713	Sodium-dependent dopamine transporter	SLC6A3	0.0291
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0289
6020	Aldehyde oxidase	AOX1	0.0288
696	Kappa-type opioid receptor	OPRK1	0.0286
833	Organic cation/carnitine transporter 1	SLC22A4	0.0284
318	Alpha-2A adrenergic receptor	ADRA2A	0.0282
3941	Amine oxidase [flavin-containing] A	MAOA	0.0279
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0277
731	HIV-1 protease	HIV-1 protease	0.0272
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0268
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0268
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0267
738	Monocarboxylate transporter 1	SLC16A1	0.025
3957	Adenosine deaminase	ADA	0.0248
632	Alpha-1B adrenergic receptor	ADRA1B	0.0246
23	D(1A) dopamine receptor	DRD1	0.0243
193	Beta-1 adrenergic receptor	ADRB1	0.0242
468	Cytochrome P450 4A11	CYP4A11	0.0238
638	D(3) dopamine receptor	DRD3	0.0235
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0231
3947	Xanthine dehydrogenase/oxidase	XDH	0.0231
6141	Sodium/bile acid cotransporter	SLC10A1	0.0227
311	RNA-directed RNA polymerase catalytic subunit	PB1	0.0227
752	Large structural protein	L	0.0227
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0217
295	Carbonic anhydrase 1	CA1	0.0217
3639	Thymidine phosphorylase	deoA	0.0216
3936	Thymidine phosphorylase	TYMP	0.0216
592	Carbonic anhydrase 4	CA4	0.0214
817	DNA topoisomerase 2-alpha	TOP2A	0.0213
404	DNA gyrase subunit A	gyrA	0.0212
6224	DNA gyrase subunit A	gyrA	0.0212
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0212
136	Estrogen receptor	ESR1	0.0212
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0211
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0204
140	30S ribosomal protein S9	rpsI	0.0198
6719	30S ribosomal protein S9	rpsI	0.0198
6725	30S ribosomal protein S9	rpsI	0.0198
260	Cytochrome P450 51	ERG11	0.0198
761	Cytochrome P450 51	ERG11	0.0198
3163	Cytochrome P450 51	cyp51	0.0198
338	DNA polymerase	UL30	0.0197
379	DNA polymerase	UL54	0.0197
697	DNA polymerase	ORF28	0.0197
2482	DNA polymerase	43	0.0197
4104	DNA polymerase	BALF5	0.0197
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0197
289	Cytosolic purine 5'-nucleotidase	NT5C2	0.0196
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0196
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0193
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0193
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0192
6182	Cytochrome P450 2J2	CYP2J2	0.0192
633	Penicillin-binding proteins 1A/1B	pbpA	0.0192
6174	50S ribosomal protein L32	rpmF	0.0192
614	Progesterone receptor	PGR	0.0186
22	30S ribosomal protein S4	rpsD	0.0185
6714	30S ribosomal protein S4	rpsD	0.0185
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0185
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0184
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0182
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0181
274	Muscarinic acetylcholine receptor M5	CHRM5	0.018
508	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	ENPP1	0.0179
3939	Amine oxidase [flavin-containing] B	MAOB	0.0178
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0175
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0172
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0172
146	Androgen receptor	AR	0.017
357	Carbonic anhydrase 2	CA2	0.017
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.017
756	Sex hormone-binding globulin	SHBG	0.017
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0169
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0168
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0167
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0166
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0166
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0164
380	Cytochrome P450 17A1	CYP17A1	0.0164
629	Alpha-2B adrenergic receptor	ADRA2B	0.0162
723	Cytosolic phospholipase A2	PLA2G4A	0.0161
465	Calmodulin	CALM1	0.016
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.016
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.016
6021	Adenosine kinase	ADK	0.0159
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0159
378	Alpha-2C adrenergic receptor	ADRA2C	0.0159
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0157
432	D(4) dopamine receptor	DRD4	0.0156
232	Corticosteroid-binding globulin	SERPINA6	0.0156
737	Mineralocorticoid receptor	NR3C2	0.0155
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0154
818	50S ribosomal protein L10	rplJ	0.0148
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0147
1483	Membrane copper amine oxidase	AOC3	0.0146
6014	Cytochrome P450 2A13	CYP2A13	0.0145
6012	Tryptophan 2,3-dioxygenase	TDO2	0.0145
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0144
5849	cAMP-dependent protein kinase type I-alpha regulatory subunit	PRKAR1A	0.0143
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0142
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0142
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0141
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0141
891	Dihydropteroate synthase	folP	0.014
5359	Dihydropteroate synthase	folP	0.014
7175	Dihydropteroate synthase	sulI	0.014
5626	Nucleoside diphosphate kinase B	NME2	0.0139
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0139
3913	Glutamic acid decarboxylase	GAD65	0.0138
477	DNA topoisomerase 4 subunit A	parC	0.0138
886	DNA topoisomerase 4 subunit A	parC	0.0138
6226	DNA topoisomerase 4 subunit A	parC	0.0138
811	Translocator protein	TSPO	0.0138
1405	Thiopurine S-methyltransferase	TPMT	0.0137
1178	Adenosine A2a receptor	ADORA2A	0.0135
4122	Histone deacetylase 2	HDAC2	0.0135
4226	Uridine phosphorylase 2	UPP2	0.0134
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0134
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0134
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0133
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0133
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0133
645	Penicillin-binding protein 1A	mrcA	0.0132
5805	Penicillin-binding protein 1A	ponA	0.0132
6185	Penicillin-binding protein 1A	mrcA	0.0132
6799	Penicillin-binding protein 1A	pbpA	0.0132
789	Alpha-1D adrenergic receptor	ADRA1D	0.0132
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0132
6111	DNA polymerase epsilon subunit 4	POLE4	0.0131
6112	DNA polymerase epsilon subunit 3	POLE3	0.0131
6108	Ribonucleoside-diphosphate reductase subunit M2 B	RRM2B	0.0131
6110	DNA polymerase epsilon subunit 2	POLE2	0.0131
6109	DNA polymerase epsilon catalytic subunit A	POLE	0.0131
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.013
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.013
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.013
122	P2Y purinoceptor 12	P2RY12	0.013
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.013
725	5-hydroxytryptamine 1D receptor	HTR1D	0.013
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0129
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0129
16	Adenosine A1 receptor	ADORA1	0.0129
6126	Carbonic anhydrase 7	CA7	0.0127
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0127
4604	Liver carboxylesterase 1	CES1	0.0127
504	Mast/stem cell growth factor receptor	KIT	0.0127
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0127
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.0126
87	Hypoxanthine-guanine phosphoribosyltransferase	HPRT1	0.0125
5353	Glutamate decarboxylase alpha	gadA	0.0125
29	Tubulin beta-1 chain	TUBB1	0.0123
6137	Multidrug resistance-associated protein 6	ABCC6	0.0123
308	30S ribosomal protein S12	rpsL	0.0122
6704	30S ribosomal protein S12	rpsL	0.0122
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0122
4225	Uridine phosphorylase 1	UPP1	0.0121
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0121
5294	Nucleoside diphosphate kinase A	NME1	0.0119
275	Arachidonate 5-lipoxygenase	ALOX5	0.0118
527	Prostacyclin receptor	PTGIR	0.0117
3904	Alanine aminotransferase 2	GPT2	0.0116
735	Alanine aminotransferase 1	GPT	0.0116
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0115
4237	50S ribosomal protein L22	rplV	0.0115
642	3-oxo-5-alpha-steroid 4-dehydrogenase 2	SRD5A2	0.0115
284	DNA-directed RNA polymerase beta chain	rpoB	0.0115
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0115
70	Type-1 angiotensin II receptor	AGTR1	0.0115
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0112
94	5-hydroxytryptamine 4 receptor	HTR4	0.0112
413	Amidophosphoribosyltransferase	PPAT	0.0112
2515	Amidophosphoribosyltransferase	purF	0.0112
3714	Amidophosphoribosyltransferase	purF	0.0112
3923	Cholinesterase	BCHE	0.0111
469	Annexin A1	ANXA1	0.011
4790	Glycosyltransferase GtfA	gtfA	0.011
844	Epidermal growth factor receptor	EGFR	0.011
84	Nuclear receptor 0B1	NR0B1	0.0108
716	5-hydroxytryptamine 7 receptor	HTR7	0.0108
4238	50S ribosomal protein L4	rplD	0.0105
5578	50S ribosomal protein L4	rplD	0.0105
6173	50S ribosomal protein L4	rplD	0.0105
6219	50S ribosomal protein L4	rplD	0.0105
1867	Major prion protein	PRNP	0.0105
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0104
558	Solute carrier family 12 member 1	SLC12A1	0.0104
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0104
6149	Solute carrier family 22 member 10	SLC22A10	0.0104
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0102
543	Penicillin-binding protein 1B	mrcB	0.0102
6186	Penicillin-binding protein 1B	ponB	0.0102
6822	Penicillin-binding protein 1b	pbp1b	0.0102
6844	Penicillin-binding protein 1b	pbp1b	0.0102
677	Choline-phosphate cytidylyltransferase A	PCYT1A	0.0102
124	Histamine H2 receptor	HRH2	0.0102
4218	Ribonucleoside-diphosphate reductase M2 subunit	RRM2	0.0102
407	Vascular endothelial growth factor receptor 2	KDR	0.0101
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0101
6220	Aryl hydrocarbon receptor	AHR	0.0101
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0099
474	Acetylcholinesterase	ACHE	0.0098
163	D(1B) dopamine receptor	DRD5	0.0097
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0096
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0096
3688	Branched-chain-amino-acid aminotransferase	ilvE	0.0095
2320	Thymidine kinase, cytosolic	TK1	0.0093
267	Plasminogen activator inhibitor 1	SERPINE1	0.0093
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0093
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0092
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0092
244	Angiotensin-converting enzyme	ACE	0.0092
6207	30S ribosomal protein S14	rpsN	0.009
6209	30S ribosomal protein S19	rpsS	0.009
6712	30S ribosomal protein S19	rpsS	0.009
6726	30S ribosomal protein S19	rpsS	0.009
1244	Low-density lipoprotein receptor-related protein 2	LRP2	0.009
3685	Catabolite gene activator	crp	0.0089
4655	Adenylate cyclase	cyaC	0.0089
4759	Adenylate cyclase	cyaB2	0.0089
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0089
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0089
183	Vascular endothelial growth factor A	VEGFA	0.0089
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0089
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0089
427	Substance-P receptor	TACR1	0.0089
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0089
1852	Microtubule-associated protein 2	MAP2	0.0088
1656	CYP2B protein	CYP2B	0.0088
161	Tubulin beta chain	TUBB	0.0088
312	Tubulin beta chain	TUB2	0.0088
1010	Cytochrome P450 51A1	CYP51A1	0.0087
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0087
273	Apoptosis regulator Bcl-2	BCL2	0.0087
26	Vascular endothelial growth factor receptor 3	FLT4	0.0087
952	Dipeptidyl peptidase 4	DPP4	0.0087
3809	Estrogen-related receptor gamma	ESRRG	0.0086
6102	Arylamine N-acetyltransferase 2	NAT2	0.0086
373	Transthyretin	TTR	0.0086
1757	Myeloperoxidase	MPO	0.0085
5924	Microtubule-associated protein 4	MAP4	0.0085
5923	Microtubule-associated protein tau	MAPT	0.0085
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0085
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0083
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0083
768	FK506-binding protein 1A	FKBP1A	0.0083
32	Vascular endothelial growth factor receptor 1	FLT1	0.0083
6221	Steroid hormone receptor ERR1	ESRRA	0.0082
6033	High affinity interleukin-8 receptor A	CXCR1	0.0082
2016	Dipeptidase 1	DPEP1	0.0082
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0081
6043	Putative G-protein coupled receptor 44	GPR44	0.008
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0079
4120	NADPH--cytochrome P450 reductase	POR	0.0079
777	Tumor necrosis factor	TNF	0.0078
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0078
705	Glutamate receptor 1	GRIA1	0.0078
2249	Aspartate aminotransferase	aspC	0.0077
2671	Aspartate aminotransferase	aspC	0.0077
5490	Aspartate aminotransferase	Not Available	0.0077
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0077
4760	Mll3241 protein	mll3241	0.0076
131	Synaptic vesicular amine transporter	SLC18A2	0.0076
3932	Glutathione S-transferase A2	GSTA2	0.0075
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0074
1196	Complement decay-accelerating factor	CD55	0.0074
4116	Dihydropteroate synthetase	Not Available	0.0072
65	Matrix metalloproteinase-9	Not Available	0.0072
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0072
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0072
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0071
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0071
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0071
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.007
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0069
1050	Bile salt sulfotransferase	SULT2A1	0.0069
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0069
49	Endothelin B receptor	EDNRB	0.0069
672	Prostaglandin F2-alpha receptor	PTGFR	0.0069
130	Prostacyclin synthase	PTGIS	0.0069
115	Penicillin-binding protein 2	mrdA	0.0069
6069	Penicillin-binding protein 2	mrdA	0.0069
6118	Penicillin-binding protein 2	penA	0.0069
6187	Penicillin-binding protein 2	pbpA	0.0069
6686	Penicillin-binding protein 2	pbp2	0.0069
6939	Penicillin-binding protein 2	mrdA	0.0069
7163	Penicillin-binding protein 2	pbpA	0.0069
2112	Toll-like receptor 9	TLR9	0.0069
814	Ryanodine receptor 1	RYR1	0.0067
4203	Histamine N-methyltransferase	HNMT	0.0066
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0066
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0066
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0065
578	Endothelin-1 receptor	EDNRA	0.0065
867	Penicillin-binding protein 3	pbpC	0.0065
6119	Penicillin-binding protein 3	pbp3	0.0065
7154	Penicillin-binding protein 3	pbp3	0.0065
7157	Penicillin-binding protein 3	LMHCC_2184	0.0065
7162	Penicillin-binding protein 3	pbpB	0.0065
7172	Penicillin-binding protein 3	pbp3	0.0065
165	FL cytokine receptor	FLT3	0.0064
1654	Interleukin-1 beta	IL1B	0.0064
2808	Chloramphenicol acetyltransferase 3	cat3	0.0064
1	Peptidoglycan synthetase ftsI	ftsI	0.0064
4155	Peptidoglycan synthetase ftsI	ftsI	0.0064
133	Dihydropterate synthase	sulI	0.0063
54	Prothrombin	F2	0.0062
6105	3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	0.0062
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.006
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.006
3810	Catechol O-methyltransferase	COMT	0.006
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.006
53	Solute carrier family 12 member 5	SLC12A5	0.006
663	Solute carrier family 12 member 4	SLC12A4	0.006
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0059
869	Estrogen receptor beta	ESR2	0.0059
2539	Tubulin alpha-1 chain	TUBA4A	0.0059
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.0059
4217	Telomerase reverse transcriptase	TERT	0.0059
2417	Chloramphenicol acetyltransferase	cat	0.0058
3278	Chloramphenicol acetyltransferase	cat	0.0058
2810	Dr hemagglutinin structural subunit	draA	0.0058
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0057
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0057
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0057
7	Nitric oxide synthase, inducible	NOS2	0.0056
310	Solute carrier family 12 member 2	SLC12A2	0.0056
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0055
153	Dopamine beta-hydroxylase	DBH	0.0055
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0055
408	Riboflavin kinase	RFK	0.0055
6506	Stathmin-4	STMN4	0.0055
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0055
466	Solute carrier family 12 member 3	SLC12A3	0.0055
1507	Cytochrome c	CYCS	0.0054
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0054
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0054
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0054
1275	Estrogen sulfotransferase	SULT1E1	0.0053
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0053
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0053
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.0053
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0052
494	Caspase-1	CASP1	0.0051
438	Taste receptor type 1 member 2	TAS1R2	0.0051
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0051
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0051
253	Sodium/potassium-transporting ATPase gamma chain	FXYD2	0.0051
1650	Heme carrier protein 1	SLC46A1	0.0051
174	Sigma 1-type opioid receptor	SIGMAR1	0.0051
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0051
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.005
5300	Antigen peptide transporter 1	TAP1	0.005
6085	Fatty acid-binding protein, intestinal	FABP2	0.0049
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0049
173	Toll-like receptor 7	TLR7	0.0049
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0048
459	Retinoic acid receptor RXR-alpha	RXRA	0.0048
780	Retinoic acid receptor RXR-gamma	RXRG	0.0048
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0048
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0048
6167	Organic solute transporter subunit beta	OSTB	0.0047
6166	Organic solute transporter subunit alpha	OSTA	0.0047
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0047
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0047
3760	Penicillin-binding protein 5 precursor	dacA	0.0046
565	Extracellular calcium-sensing receptor	CASR	0.0046
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0046
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0046
1039	Histone deacetylase 9	HDAC9	0.0046
1192	Sulfotransferase 1A1	SULT1A1	0.0046
3086	Plasmepsin-2	Not Available	0.0046
856	Vitamin D3 receptor	VDR	0.0046
68	Cannabinoid receptor 1	CNR1	0.0046
239	Coagulation factor X	F10	0.0046
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0046
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0046
3686	Acyl-CoA thioesterase I precursor	tesA	0.0045
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0045
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0045
6131	Carbonic anhydrase 14	CA14	0.0044
6339	Ig kappa chain V-II region RPMI 6410	Not Available	0.0044
6184	D-alanyl-D-alanine carboxypeptidase dacC	dacC	0.0044
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0044
482	Glycine receptor subunit alpha-1	GLRA1	0.0044
268	Adenosine A2b receptor	ADORA2B	0.0044
319	Opioid receptor, sigma 1	OPRS1	0.0044
88	Retinoic acid receptor RXR-beta	RXRB	0.0043
293	Gamma-glutamyl hydrolase	GGH	0.0043
1618	High affinity nerve growth factor receptor	NTRK1	0.0043
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0043
2077	Caspase-3	CASP3	0.0043
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0043
1517	Beta-3 adrenergic receptor	ADRB3	0.0043
5698	Riboflavin synthase alpha chain	ribE	0.0043
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0042
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0042
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0042
823	Fibroblast growth factor receptor 2	FGFR2	0.0042
819	Penicillin-binding protein 4	dacB	0.0042
1630	Integrin beta-2	ITGB2	0.0042
3601	Dihydropteroate synthase 1	folP1	0.0041
3807	Dihydropteroate synthase 1	folP1	0.0041
3808	Dihydropteroate synthase 2	folP2	0.0041
887	DNA gyrase subunit B	gyrB	0.0041
4150	DNA gyrase subunit B	gyrB	0.0041
6225	DNA gyrase subunit B	gyrB	0.0041
1629	Transcription factor AP-1	JUN	0.0041
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0041
976	Platelet glycoprotein IX	GP9	0.0041
6122	Carbonic anhydrase 3	CA3	0.0041
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0041
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.004
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.004
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.004
1558	Transient receptor potential cation channel subfamily V member 1	TRPV1	0.004
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0039
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0039
6218	Pannexin-1	PANX1	0.0039
2268	Cholesterol oxidase	choB	0.0039
2822	Cholesterol oxidase	choA	0.0039
1541	Metalloproteinase	mmp20	0.0039
1129	C-C chemokine receptor type 5	CCR5	0.0039
4209	ATP-sensitive inward rectifier potassium channel 8	KCNJ8	0.0038
571	Melatonin receptor type 1A	MTNR1A	0.0038
362	Melatonin receptor type 1B	MTNR1B	0.0038
2461	D-alanyl-D-alanine carboxypeptidase	Not Available	0.0038
5756	D-alanyl-D-alanine carboxypeptidase	dac	0.0038
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0037
1525	Heparin-binding growth factor 2	FGF2	0.0037
2283	Steroid Delta-isomerase	ksi	0.0037
2920	Steroid Delta-isomerase	ksi	0.0037
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0037
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0036
707	72 kDa type IV collagenase	MMP2	0.0036
6048	Troponin C, skeletal muscle	TNNC2	0.0035
185	Vasopressin V1a receptor	AVPR1A	0.0035
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0035
889	3-oxoacyl-[acyl-carrier-protein] synthase 1	fabB	0.0035
6860	3-oxoacyl-[acyl-carrier-protein] synthase 1	kasA	0.0035
1025	Aquaporin-1	AQP1	0.0035
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0035
939	50S ribosomal protein L3	rplC	0.0035
33	Cystine/glutamate transporter	SLC7A11	0.0035
322	Vasopressin V2 receptor	AVPR2	0.0034
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0034
3007	Carbonic anhydrase 12	CA12	0.0034
4205	Carbonic anhydrase 9	CA9	0.0034
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0034
6044	Serum paraoxonase/lactonase 3	PON3	0.0034
634	Squalene monooxygenase	SQLE	0.0033
7196	Squalene monooxygenase	ERG1	0.0033
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0033
4311	tRNA	TRDMT1	0.0033
4325	tRNA	trmD	0.0033
4328	tRNA	trmD	0.0033
332	Beta-lactamase	blaZ	0.0033
2478	Beta-lactamase	ampC	0.0033
2613	Beta-lactamase	ampC	0.0033
2635	Beta-lactamase	ampC	0.0033
2700	Beta-lactamase	penP	0.0033
5445	Beta-lactamase	blaB	0.0033
6019	Beta-lactamase	SHV-7	0.0033
6701	Beta-lactamase	cphA	0.0033
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0032
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0032
6042	Prostaglandin reductase 2	PTGR2	0.0032
921	Glutamate receptor 2	GRIA2	0.0032
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0032
1770	Phospholipase C	PLCL1	0.0032
2841	Phospholipase C	plc	0.0032
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0031
1636	Trace amine-associated receptor 1	TAAR1	0.0031
572	Integrin alpha-L	ITGAL	0.0031
1227	Cytochrome b	MT-CYB	0.0031
6386	Cytochrome b	petB	0.0031
6937	Cytochrome b	MT-CYB	0.0031
674	Dihydroorotate dehydrogenase homolog, mitochondrial	PFF0160c	0.0031
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0031
342	P protein [Includes: DNA-directed DNA polymerase	P	0.0031
612	P protein [Includes: DNA-directed DNA polymerase	P	0.0031
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0031
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0031
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.003
2578	Tubulin beta-3 chain	TUBB3	0.003
1353	DNA topoisomerase 1	TOP1	0.003
3552	DNA topoisomerase 1	topA	0.003
2285	Streptogramin A acetyltransferase	vatD	0.003
1864	RET proto-oncogene	RET	0.003
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.003
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.003
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.003
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.003
581	Cytochrome P450 2R1	CYP2R1	0.003
719	Retinoic acid receptor responder protein 1	RARRES1	0.003
770	Retinoic acid-induced protein 3	GPRC5A	0.003
654	Flavin reductase	BLVRB	0.0029
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0029
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0029
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0029
5818	Folate receptor alpha	FOLR1	0.0029
164	Histamine H4 receptor	HRH4	0.0029
424	Dihydroorotate dehydrogenase, mitochondrial	DHODH	0.0029
4252	Penicillin-binding protein 5	dacA	0.0028
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0028
518	Peroxidase/catalase T	katG	0.0028
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0028
159	Penicillin-binding protein 2B	penA	0.0028
6121	Penicillin-binding protein 2B	penA	0.0028
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.0028
3856	Fibroblast growth factor receptor 3	FGFR3	0.0028
1200	AMBP protein	AMBP	0.0028
3866	Serum amyloid A protein	SAA1	0.0028
1932	Apolipoprotein E	APOE	0.0028
5934	Cytochrome P450 26A1	CYP26A1	0.0027
1144	Hepatocyte growth factor receptor	MET	0.0027
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.0027
2449	Tubulin alpha-3 chain	TUBA1A	0.0027
4173	Tyrosine-protein kinase JAK2	JAK2	0.0027
2159	Quinone oxidoreductase	CRYZ	0.0027
4228	Keratin, type II cytoskeletal 7	KRT7	0.0027
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0027
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0026
6432	Transporter	snf	0.0026
5787	Angiopoietin-1 receptor	TEK	0.0026
569	Retinal dehydrogenase 2	ALDH1A2	0.0026
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0026
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0025
509	Thymidine kinase	TK	0.0025
570	Thymidine kinase	TK	0.0025
2559	Thymidine kinase	TK	0.0025
3430	Thymidine kinase	tdk	0.0025
3518	Thymidine kinase	TK	0.0025
5301	Thymidine kinase	tdk	0.0025
5771	Thymidine kinase	ORF36	0.0025
7009	Thymidine kinase	ORF36	0.0025
6138	Multidrug resistance protein 3	ABCB4	0.0025
563	Thyroid peroxidase	TPO	0.0025
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0025
904	Glutathione S-transferase P	GSTP1	0.0025
489	Monocarboxylate transporter 2	SLC16A7	0.0025
1648	Elastin	ELN	0.0024
1313	Lactoylglutathione lyase	GLO1	0.0024
611	Retinal dehydrogenase 1	ALDH1A1	0.0024
544	Potassium voltage-gated channel subfamily E member 1	KCNE1	0.0024
1714	Mitogen-activated protein kinase 3	MAPK3	0.0024
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0024
471	Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)	SLC6A14	0.0024
233	Potassium channel subfamily K member 2	KCNK2	0.0024
5852	Type-2 angiotensin II receptor	AGTR2	0.0024
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0023
1341	Histamine H3 receptor	HRH3	0.0023
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0023
3587	Gastrotropin	FABP6	0.0023
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0022
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0022
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0022
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0022
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0022
3404	Exotoxin A	eta	0.0022
6824	Tyrosine-protein kinase Lyn	LYN	0.0022
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0022
2232	Interleukin-5	IL5	0.0022
298	Renin	REN	0.0021
1593	Mucin-2	MUC2	0.0021
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0021
718	Folate receptor gamma	FOLR3	0.0021
299	Folate receptor beta	FOLR2	0.0021
804	Mitochondrial folate transporter/carrier	SLC25A32	0.0021
1198	Serum paraoxonase/arylesterase 1	PON1	0.0021
6223	Penicillin-binding protein 1C	pbpC	0.0021
5287	Signaling protein	Not Available	0.0021
63	Malate dehydrogenase	mdh	0.0021
2329	Malate dehydrogenase	mdh	0.0021
3445	Malate dehydrogenase	mdh	0.0021
4420	Malate dehydrogenase	mdh	0.0021
4438	Malate dehydrogenase	mdh	0.0021
5288	Shikimate kinase	aroK	0.0021
5304	UPF0166 protein TM_0021	TM_0021	0.0021
5270	ATP-dependent Clp protease ATP-binding subunit clpX	clpX	0.0021
5314	UPF0079 ATP-binding protein HI0065	HI_0065	0.0021
5259	Transcriptional regulator	ntrC1	0.0021
6699	Transcriptional regulator	Cgl2612	0.0021
5290	ATP-dependent hsl protease ATP-binding subunit hslU	hslU	0.0021
5638	ATP-dependent hsl protease ATP-binding subunit hslU	hslU	0.0021
3199	Phosphopantetheine adenylyltransferase	coaD	0.0021
3543	Phosphopantetheine adenylyltransferase	coaD	0.0021
3567	Phosphopantetheine adenylyltransferase	coaD	0.0021
5289	Phosphopantetheine adenylyltransferase	coaD	0.0021
2874	Nitrogenase iron protein 1	nifH1	0.0021
4346	Polynucleotide kinase	pseT	0.0021
5293	Shikimate kinase 2	aroL	0.0021
5292	Putative partitioning protein	TT_C1605	0.0021
5281	Plasmid segregation protein parM	parM	0.0021
5305	Phosphoribosylaminoimidazole carboxylase ATPase subunit	purK	0.0021
5299	D-alanine--D-alanine ligase	ddl	0.0021
6598	D-alanine--D-alanine ligase	ddl	0.0021
5276	Chromosomal replication initiator protein dnaA	dnaA	0.0021
5266	Activator of	hgdC	0.0021
4794	Phosphoenolpyruvate carboxykinase [ATP]	pckA	0.0021
5283	D-alanine--D-alanine ligase B	ddlB	0.0021
5275	Multidrug resistance ABC transporter ATP-binding and permease protein	lmrA	0.0021
5308	Preprotein translocase secA 1 subunit	secA1	0.0021
5315	Chaperone protein htpG	htpG	0.0021
1549	Heat shock 70 kDa protein 1	HSPA1A	0.0021
5284	Large T antigen	Not Available	0.0021
3777	ATP-dependent Clp protease ATP-binding subunit clpA	clpA	0.0021
3982	Phosphoribosylformylglycinamidine synthase	PFAS	0.0021
5261	Phosphoribosylformylglycinamidine synthase	purL	0.0021
5277	Preprotein translocase subunit secA	secA	0.0021
5291	Glycogen synthase 1	glgA1	0.0021
5264	DNA replication protein	REP	0.0021
5285	Kinesin heavy chain	KIF5B	0.0021
4192	DNA topoisomerase 2-beta	TOP2B	0.0021
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.002
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.002
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.002
751	Potassium channel subfamily K member 6	KCNK6	0.002
2216	Fibroblast growth factor receptor 4	FGFR4	0.002
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.002
6103	Arylamine N-acetyltransferase 1	NAT1	0.002
6146	High affinity copper uptake protein 1	SLC31A1	0.002
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.002
2499	Tubulin beta-2C chain	TUBB2C	0.0019
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0019
473	L-lactate dehydrogenase A chain	LDHA	0.0019
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0019
162	Retinoic acid receptor gamma-1	RARG	0.0019
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0019
1992	Vitamin D-binding protein	GC	0.0019
172	Potassium channel subfamily K member 1	KCNK1	0.0018
893	[Citrate [pro-3S]-lyase] ligase	citC	0.0018
845	Pyruvate dehydrogenase [cytochrome]	poxB	0.0018
2391	Ferrochelatase	hemH	0.0018
6502	Ferrochelatase	DKFZp686P18130	0.0018
1591	Ferrochelatase, mitochondrial	FECH	0.0018
5998	Toll-like receptor 8	TLR8	0.0018
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0018
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0018
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0018
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0018
712	Tubulin alpha chain	TUB1	0.0018
936	Ephrin type-A receptor 2	EPHA2	0.0018
1968	ATP-sensitive inward rectifier potassium channel 12	KCNJ12	0.0018
327	Glutathione reductase	gor	0.0018
5110	Glutathione reductase	GR2	0.0018
683	Potassium transporter	GK0582	0.0018
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.0018
517	Alcohol dehydrogenase 1C	ADH1C	0.0018
2091	Endoplasmin	HSP90B1	0.0018
1123	Eosinophil cationic protein	RNASE3	0.0018
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0017
613	Atrial natriuretic peptide receptor A	NPR1	0.0017
4103	Proteasome subunit beta type 2	PSMB2	0.0017
4102	Proteasome subunit beta type 5	PSMB5	0.0017
4101	Proteasome subunit beta type 1	PSMB1	0.0017
2290	ADP-ribosyl cyclase 2	BST1	0.0017
1374	Natriuretic peptides B	NPPB	0.0017
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.0017
1827	Gap junction alpha-1 protein	GJA1	0.0017
1908	Vascular cell adhesion protein 1	VCAM1	0.0017
106	Cannabinoid receptor 2	CNR2	0.0017
2021	Thrombomodulin	THBD	0.0017
992	Protein tyrosine kinase 2 beta	PTK2B	0.0017
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0017
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0017
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0017
4106	Guanylate kinase	GUK1	0.0016
4516	Guanylate kinase	gmk	0.0016
78	Acetyl-CoA acetyltransferase, mitochondrial	ACAT1	0.0016
144	Hemoglobin subunit alpha	HBA1	0.0016
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0016
6277	Heat shock cognate 71 kDa protein	HSPA8	0.0016
3390	Aminoglycoside 3'-phosphotransferase	aphA	0.0016
6029	Aminoglycoside 3'-phosphotransferase	aphA1	0.0016
4837	Cag-alfa	cag-alfa	0.0016
5646	Galactokinase	GALK1	0.0016
5302	TrwB	trwB	0.0016
4839	DNA polymerase III subunit tau	dnaX	0.0016
4774	NTPase P4	Not Available	0.0016
4838	PMS1 protein homolog 2	PMS2	0.0016
5265	FtsH	ftsH	0.0016
340	Apoptotic protease-activating factor 1	APAF1	0.0016
6497	Cytochrome c oxidase subunit 6A2, mitochondrial	COX6A2	0.0016
6496	Cytochrome c oxidase subunit 8A, mitochondrial	COX8A	0.0016
6495	Cytochrome c oxidase subunit 7C, mitochondrial	COX7C	0.0016
6493	Cytochrome c oxidase subunit 6C	COX6C	0.0016
6499	Cytochrome c oxidase polypeptide 7A1, mitochondrial	COX7A1	0.0016
6494	Cytochrome c oxidase subunit 7B, mitochondrial	COX7B	0.0016
6498	Cytochrome c oxidase subunit 6B1	COX6B1	0.0016
6490	Cytochrome c oxidase subunit 3	MT-CO3	0.0016
6489	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	COX4I1	0.0016
6491	Cytochrome c oxidase subunit 5A, mitochondrial	COX5A	0.0016
371	Cytochrome c oxidase subunit 1	MT-CO1	0.0016
6558	Cytochrome c oxidase subunit 1	ctaD	0.0016
5793	Cytochrome c oxidase subunit 2	MT-CO2	0.0016
6559	Cytochrome c oxidase subunit 2	ctaC	0.0016
6669	Cytochrome c oxidase subunit 2	ctaC	0.0016
2270	Dephospho-CoA kinase	coaE	0.0016
5189	Trimethylamine dehydrogenase	tmd	0.0016
2284	Adenylate kinase	adk	0.0016
2296	Adenylate kinase	adk	0.0016
2311	Adenylate kinase	adk	0.0016
2312	Adenylate kinase	Not Available	0.0016
3233	Bile acid receptor	NR1H4	0.0015
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0015
2853	14 kDa fatty acid-binding protein	Not Available	0.0015
5295	2-keto-3-deoxy-gluconate kinase	TT_P0036	0.0015
2751	Holliday junction ATP-dependent DNA helicase ruvB	ruvB	0.0015
4755	Holliday junction ATP-dependent DNA helicase ruvB	ruvB	0.0015
3470	Hypothetical protein MG245 homolog	MPN_348	0.0015
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0015
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0015
982	Cocaine- and amphetamine-regulated transcript protein	CARTPT	0.0015
3175	Glutamate--cysteine ligase	gshA	0.0015
3426	Glutamine synthetase	glnA	0.0015
3987	Glutamine synthetase	GLUL	0.0015
2683	Mono-ADP-ribosyltransferase C3	C3	0.0015
3937	Fatty-acid amide hydrolase	FAAH	0.0015
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0015
2540	Choloylglycine hydrolase	cbh	0.0014
2390	Nonsecretory ribonuclease	RNASE2	0.0014
5312	Kinesin-like protein KIF1A	KIF1A	0.0014
2282	Protein recA	recA	0.0014
2315	Protein recA	recA	0.0014
2332	Protein recA	recA	0.0014
5263	Protein recA	recA	0.0014
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0014
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0014
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.0014
2922	Glycerol kinase	glpK	0.0014
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.0014
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0014
1262	Corticotropin-lipotropin	POMC	0.0014
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0014
6501	Fatty acid-binding protein, liver	FABP1	0.0014
822	Aldose reductase	AKR1B1	0.0014
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0013
5271	Focal adhesion kinase 1	PTK2	0.0013
2615	Chemotaxis protein cheA	cheA	0.0013
908	Glutathione S-transferase theta-1	GSTT1	0.0013
5278	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1	PAPSS1	0.0013
6211	Tubulin epsilon chain	TUBE1	0.0013
6212	Tubulin gamma-1 chain	TUBG1	0.0013
6210	Tubulin delta chain	TUBD1	0.0013
6832	Serine/threonine-protein kinase SRPK2	SRPK2	0.0013
1881	Hexokinase-1	HK1	0.0013
2371	Pantothenate kinase	coaA	0.0013
860	Nicotinamide N-methyltransferase	NNMT	0.0013
699	Nicotinic acid receptor 1	GPR109A	0.0013
928	Nicotinic acid receptor 2	GPR109B	0.0013
583	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	QPRT	0.0013
2442	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0013
2459	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0013
3669	Ribokinase	rbsK	0.0013
6116	Gastric triacylglycerol lipase	LIPF	0.0012
2950	Inositol-trisphosphate 3-kinase A	ITPKA	0.0012
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0012
3823	Cytokine receptor common gamma chain	IL2RG	0.0012
85	Growth hormone receptor	GHR	0.0012
2892	Acetylglutamate kinase	argB	0.0012
3550	Acetylglutamate kinase	argB	0.0012
4366	Riboflavin kinase/FMN adenylyltransferase	TM_0857	0.0012
2107	Microtubule-associated protein 1A	MAP1A	0.0012
825	Arsenical pump-driving ATPase	ASNA1	0.0012
3435	Arsenical pump-driving ATPase	arsA	0.0012
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0012
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0012
1295	Fatty acid synthase	FASN	0.0012
1268	Neuropeptide S receptor	NPSR1	0.0012
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0012
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0012
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0012
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0012
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0012
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0012
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0012
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0012
2697	Uridine-cytidine kinase 2	UCK2	0.0012
6857	[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial	PDK2	0.0012
2727	S-adenosylmethionine synthetase	metK	0.0012
2236	Casein kinase II subunit alpha	CSNK2A1	0.0012
1792	Tissue-type plasminogen activator	PLAT	0.0012
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0012
201	Glutamate dehydrogenase 1, mitochondrial	GLUD1	0.0011
788	Creatine kinase M-type	CKM	0.0011
6500	Phospholipase A2	PLA2G1B	0.0011
2817	Phosphoribosylglycinamide formyltransferase 2	purT	0.0011
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0011
6390	Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	ATP2A1	0.0011
484	Tyrosine-protein kinase ABL2	ABL2	0.0011
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0011
453	S-adenosylmethionine synthetase isoform type-1	MAT1A	0.0011
754	Pancreatic triacylglycerol lipase	PNLIP	0.0011
48	Pyridoxal kinase	PDXK	0.0011
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0011
6073	Potassium channel subfamily K member 9	KCNK9	0.0011
2251	Thymidylate kinase	tmk	0.0011
2254	Thymidylate kinase	DTYMK	0.0011
3522	Thymidylate kinase	tmk	0.0011
6072	Potassium channel subfamily K member 3	KCNK3	0.0011
61	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK	0.0011
2644	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK	0.0011
2710	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK	0.0011
896	Glutathione S-transferase Mu 1	GSTM1	0.0011
2178	Metabotropic glutamate receptor 5	GRM5	0.0011
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0011
724	Interleukin-2 receptor alpha chain	IL2RA	0.0011
717	Interleukin-2 receptor subunit beta	IL2RB	0.0011
605	Fumarate reductase flavoprotein subunit	frdA	0.0011
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0011
3673	Fumarate reductase flavoprotein subunit	fccA	0.0011
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0011
6549	Fumarate reductase flavoprotein subunit	frdA	0.0011
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.001
2300	Lysozyme	E	0.001
3633	Lysozyme	R	0.001
5597	Lysozyme	17	0.001
207	Glutathione synthetase	GSS	0.001
5269	Glutathione synthetase	gshB	0.001
2334	Dethiobiotin synthetase	bioD	0.001
6555	Dethiobiotin synthetase	bioD	0.001
1810	Protein S100-A1	S100A1	0.001
6097	Protein S100-A2	S100A2	0.001
997	Protein kinase C beta type	PRKCB	0.001
291	Nitric-oxide synthase, endothelial	NOS3	0.001
493	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	0.001
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.001
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.001
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.001
512	DNA-directed RNA polymerase alpha chain	rpoA	0.001
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.001
4041	Microsomal glutathione S-transferase 2	MGST2	0.001
2511	MAP kinase-activated protein kinase 2	MAPKAPK2	0.001
251	Alcohol dehydrogenase 1A	ADH1A	0.001
1970	Protein kinase C alpha type	PRKCA	0.001
2317	UDP-N-acetylmuramoylalanine--D-glutamate ligase	murD	0.001
6395	Myosin-14	MYH14	0.0009
2408	Tyrosine-protein kinase SYK	SYK	0.0009
820	Glycine receptor subunit alpha-2	GLRA2	0.0009
1422	Serine/threonine-protein kinase 6	AURKA	0.0009
828	Phenylalanine-4-hydroxylase	PAH	0.0009
3109	Phenylalanine-4-hydroxylase	phhA	0.0009
1048	Protein S100-A13	S100A13	0.0009
2226	Protein S100-A12	S100A12	0.0009
3379	Kinesin-like protein KIF11	KIF11	0.0009
3456	Heat shock protein HSP 90-beta	HSP90AB1	0.0009
444	Alcohol dehydrogenase 1B	ADH1B	0.0009
390	Adenosine A3 receptor	ADORA3	0.0009
3822	Actin, alpha skeletal muscle	ACTA1	0.0009
2132	Protein S100-B	S100B	0.0009
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0008
5798	Mitogen-activated protein kinase 11	MAPK11	0.0008
2207	Rhodopsin	RHO	0.0008
5682	Ribonuclease pancreatic	RNASE1	0.0008
1721	Glycogen synthase kinase-3 beta	GSK3B	0.0008
4948	Cytochrome c-553	Not Available	0.0008
4923	Cytochrome c3	DvMF_2499	0.0008
4945	Cytochrome c3	Not Available	0.0008
4949	Cytochrome c3	DVU_3171	0.0008
4968	Cytochrome c3	cytc3	0.0008
4997	Cytochrome c3	SO_2727	0.0008
5219	Cytochrome c3	cyd	0.0008
4902	Nine-heme cytochrome c	Ddes_2038	0.0008
3189	High-molecular-weight cytochrome c	hmcA	0.0008
4031	Glutathione S-transferase A1	GSTA1	0.0008
500	Monocarboxylate transporter 4	SLC16A3	0.0008
1649	Small inducible cytokine A2	CCL2	0.0008
3830	Calreticulin	CALR	0.0008
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.0007
2298	Cytochrome P450-cam	camC	0.0007
866	Large neutral amino acids transporter small subunit 2	SLC7A8	0.0007
461	Glycine receptor subunit alpha-3	GLRA3	0.0007
760	Fibroblast growth factor 1	FGF1	0.0007
6034	Hydroxyindole O-methyltransferase	ASMT	0.0007
6035	Nuclear receptor ROR-beta	RORB	0.0007
6036	Eosinophil peroxidase	EPX	0.0007
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.0007
226	Gonadotropin-releasing hormone receptor	GNRHR	0.0007
4386	Hemoglobin-like protein HbN	glbN	0.0007
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0007
2599	Tyrosine-protein kinase HCK	HCK	0.0007
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0006
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0006
6263	cAMP-dependent protein kinase catalytic subunit alpha	PRKACA	0.0006
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0006
3221	Cytochrome c4	cc4	0.0006
765	Indoleamine 2,3-dioxygenase	IDO1	0.0006
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0006
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0006
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0006
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0006
6168	Solute carrier family 22 member 16	SLC22A16	0.0006
1291	cAMP response element-binding protein	CREB1	0.0006
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0006
1569	G1/S-specific cyclin-D1	CCND1	0.0006
5221	Cytochrome c3, 13 kDa	Not Available	0.0006
3152	Cytochrome c''	cycA	0.0006
5220	Split-Soret cytochrome c	Ddes_2150	0.0006
3700	Cytochrome c-552 precursor	nrfA	0.0006
4210	Toll-like receptor 4	TLR4	0.0005
1760	Aminopeptidase N	ANPEP	0.0005
6843	Aminopeptidase N	pepN	0.0005
117	Sterol O-acyltransferase 1	SOAT1	0.0005
6151	Monocarboxylate transporter 10	SLC16A10	0.0005
76	Nitric-oxide synthase, brain	NOS1	0.0005
3127	Nitrite reductase	nirS	0.0005
3284	Nitrite reductase	nirS	0.0005
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0004
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0004
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0004
3405	Quinohaemoprotein ethanol dehydrogenase type-1	qheDH	0.0004
6163	Copper-transporting ATPase 2	ATP7B	0.0004
6165	Copper-transporting ATPase 1	ATP7A	0.0004
1176	Mitogen-activated protein kinase 1	MAPK1	0.0004
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0004
594	Thyroxine-binding globulin	SERPINA7	0.0004
758	Thyroid hormone receptor alpha	THRA	0.0003
2240	Cell division protein kinase 2	CDK2	0.0003
199	Monocarboxylate transporter 8	SLC16A2	0.0003
346	Thyroid hormone receptor beta-1	THRB	0.0003
4954	Soluble cytochrome b558	Not Available	0.0003
4916	Cyanoglobin	glbN	0.0003
4934	Cytochrome c-551	nirM	0.0003
5218	Cytochrome c-551	nirM	0.0003
4947	Bacterial hemoglobin	vhb	0.0003
4915	Cytochrome c-550	psbV	0.0003
4959	Cytochrome c-550	psbV	0.0003
5216	Cytochrome c-550	psbV	0.0003
4925	Cytochrome c-type protein SHP	shp	0.0003
4905	Cytochrome c2	Not Available	0.0003
4939	Cytochrome c2	cycA	0.0003
4964	Cytochrome c2	cycA	0.0003
4979	Cytochrome c2	cycA	0.0003
6673	Cytochrome c2	cycA	0.0003
4943	Cytochrome c6	petJ	0.0003
4998	Hemoglobin-like protein yjbI	yjbI	0.0003
4984	Neuroglobin	NGB	0.0003
4936	Cytochrome c2 iso-2	Not Available	0.0003
4975	Cytochrome c-556	RPA3973	0.0003
4994	Hemoglobin-like protein HbO	glbO	0.0003
5000	HemO	hemO	0.0003
4910	Cytoglobin	CYGB	0.0003
4981	Iron-starvation protein PigA	pigA	0.0003
4909	CooA protein	cooA	0.0003
3116	Bacterioferritin	bfr	0.0003
4906	Bacterioferritin	bfr	0.0003
4965	Bacterioferritin	bfr	0.0003
4935	Cytochrome c-554	cycA1	0.0003
4907	Cytochrome c-L	moxG	0.0003
6865	Cytochrome c-L	moxG	0.0003
4971	Nonaheme cytochrome c	hmcA	0.0003
4904	Cytochrome c family protein	GSU1996	0.0003
4942	Diheme cytochrome c napB	napB	0.0003
644	Heme oxygenase 2	HMOX2	0.0003
4982	Heme oxygenase 2	pbsA2	0.0003
4989	Cytochrome c551 peroxidase	ccp	0.0003
5222	Cytochrome c551 peroxidase	ccpA	0.0003
4961	Hemophore HasA	hasA	0.0003
4976	Apocytochrome f	petA	0.0003
6407	Apocytochrome f	petA	0.0003
4764	Cytochrome P450 165C4	CYP165C4	0.0003
4931	Cytochrome P450 167A1	CYP167A1	0.0003
4960	Putative cytochrome P450-family protein	SCO7417	0.0003
4937	Cytochrome oxidase subunit II	rcoxA	0.0003
4922	Cytochrome c, putative	SO_4144	0.0003
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0003
4903	Methyl-accepting chemotaxis protein	Tar4	0.0003
4993	Hydroxylamine oxidoreductase	hao1	0.0003
4999	Cytochrome P450 165B3	CYP165B3	0.0003
4972	P450cin	cinA	0.0003
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0003
4952	Catalase/peroxidase	katA	0.0003
3093	Catalase HPII	katE	0.0003
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0003
6135	Sodium channel subunit beta-4	SCN4B	0.0002
6134	Sodium channel subunit beta-3	SCN3B	0.0002
6132	Sodium channel subunit beta-1	SCN1B	0.0002
6127	Carbonic anhydrase-related protein	CA8	0.0002
6128	Carbonic anhydrase-related protein 10	CA10	0.0002
6133	Sodium channel subunit beta-2	SCN2B	0.0002
6129	Carbonic anhydrase-related protein 11	CA11	0.0002
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0002
6130	Carbonic anhydrase 13	CA13	0.0002
4920	Peroxidase/catalase	katG	0.0002
2119	Cytochrome b5	CYB5A	0.0002
4990	PpcA	ppcA	0.0002
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0002
3375	Acidic cytochrome c3	Not Available	0.0002
4988	Sulfite oxidase, mitochondrial	SUOX	0.0002
2915	Sensor protein fixL	fixL	0.0002
4944	Sensor protein fixL	fixL	0.0002
3570	Cytochrome P450 152A1	cypC	0.0002
4385	Cytochrome c'	Not Available	0.0002
4967	Cytochrome c'	cycA	0.0002
5038	Cytochrome c'	Not Available	0.0002
5223	Cytochrome c'	cycP	0.0002
4813	Heme oxygenase	hmuO	0.0002
5769	Heme oxygenase	Not Available	0.0002
4037	Hypothetical protein	GPX1	0.0002
4297	Hypothetical protein	SP_1951	0.0002
4521	Hypothetical protein	BC_2969	0.0002
4540	Hypothetical protein	TM_1070	0.0002
4555	Hypothetical protein	MT1739	0.0002
4569	Hypothetical protein	mshD	0.0002
4578	Hypothetical protein	PA3270	0.0002
4747	Hypothetical protein	PA3967	0.0002
5177	Hypothetical protein	TM_0096	0.0002
5194	Hypothetical protein	PA1204	0.0002
5240	Hypothetical protein	Rv2991	0.0002
5370	Hypothetical protein	TM_1158	0.0002
5710	Hypothetical protein	Tb927.5.1360	0.0002
4289	Cytochrome P450	TT_P0059	0.0002
6262	Cytochrome P450	staP	0.0002
4992	Cytochrome c peroxidase	Not Available	0.0002
2230	Catalase	CAT	0.0002
3249	Catalase	katA	0.0002
3625	Catalase	katA	0.0002
4539	Catalase	katA	0.0002
4941	Catalase	katB	0.0002
3670	Soluble cytochrome b562 precursor	cybC	0.0002
3411	Cytochrome P450 121	cyp121	0.0002
3291	Cytochrome c-552	cycA	0.0002
4927	Cytochrome c-552	nrfA	0.0002
4938	Cytochrome c-552	cycA	0.0002
4953	Cytochrome c-552	nrfA	0.0002
5217	Cytochrome c-552	cycM	0.0002
2617	Nitric oxide synthase oxygenase	nos	0.0002
2701	Nitric oxide synthase oxygenase	nos	0.0002
3102	Flavohemoprotein	hmp	0.0002
4969	Flavohemoprotein	hmp	0.0002
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0001
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0001
4608	Putative cytochrome P450	SCO1207	0.0001
4963	Putative cytochrome P450	SCO2884	0.0001
6254	Putative cytochrome P450	SCO6998	0.0001
358	Cystathionine beta-synthase	CBS	0.0001
693	Hemoglobin subunit beta	HBB	0.0001
6268	Hydroxyacid oxidase 1	HAO1	0.0001
810	Heme oxygenase 1	HMOX1	0.0001
3391	Heme oxygenase 1	pbsA1	0.0001

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB00943 - Zalcitabine

Targets

Enzymes

Transporters

Predictions