DT-Web

DB02930 - Phosphothiophosphoric Acid-Adenylate Ester


Identification
Name Phosphothiophosphoric Acid-Adenylate Ester
Accession Number DB02930 (EXPT00458)
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 523.247
Groups experimental
Monoisotopic Weight 522.972901227
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Chloramphenicol 3-O phosphotransferase
Name Chloramphenicol 3-O phosphotransferase
Gene Name Not Available
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.6079
Phosphoribosylglycinamide formyltransferase 2
Name Phosphoribosylglycinamide formyltransferase 2
Gene Name purT
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.9483
Cag-alfa
Name Cag-alfa
Gene Name cag-alfa
Pharmacological action unknown
Actions Not Available
References Not Available
DTHybrid score 0.8118
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
Name 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
Gene Name PFKFB1
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.2813
PMS1 protein homolog 2
Name PMS1 protein homolog 2
Gene Name PMS2
Pharmacological action unknown
Actions Not Available
References Not Available
DTHybrid score 0.8114
DNA polymerase III subunit tau
Name DNA polymerase III subunit tau
Gene Name dnaX
Pharmacological action unknown
Actions Not Available
References Not Available
DTHybrid score 0.8117
Probable serine/threonine-protein kinase pknB
Name Probable serine/threonine-protein kinase pknB
Gene Name pknB
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.8837
ATP-dependent DNA helicase recQ
Name ATP-dependent DNA helicase recQ
Gene Name recQ
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.9114

Predictions


Id Partner name Gene Name Score
3514 Granulysin GNLY 0.1356
2803 Pyridoxine 5'-phosphate synthase pdxJ 0.1258
5312 Kinesin-like protein KIF1A KIF1A 0.1178
2615 Chemotaxis protein cheA cheA 0.1113
2314 Triosephosphate isomerase TPI 0.1094
3417 Triosephosphate isomerase tpiA 0.1094
3443 Triosephosphate isomerase tpiA 0.1094
6346 Triosephosphate isomerase TPI1 0.1094
3669 Ribokinase rbsK 0.1046
2689 Phosphoribosylglycinamide formyltransferase purN 0.1027
3500 Putative family 31 glucosidase yicI yicI 0.1026
6390 Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 ATP2A1 0.0999
1043 Trifunctional purine biosynthetic protein adenosine-3 [Includes: Phosphoribosylamine--glycine ligase GART 0.0971
6433 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 PFKFB4 0.0956
2621 Thermoresistant gluconokinase gntK 0.0927
5466 Putative sugar kinase STM4066 0.0927
4517 Probable butyrate kinase 2 buk2 0.0927
2299 UDP-N-acetylmuramate--L-alanine ligase murC 0.0925
48 Pyridoxal kinase PDXK 0.0861
3309 6-phosphofructokinase pfkA 0.0818
2717 Folylpolyglutamate synthase fgs 0.0772
36 Insulin receptor INSR 0.0659
2206 Glucose-6-phosphate isomerase GPI 0.062
4198 Fructose-1,6-bisphosphatase 1 FBP1 0.0593
1196 Complement decay-accelerating factor CD55 0.0405
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.038
2808 Chloramphenicol acetyltransferase 3 cat3 0.0359
3390 Aminoglycoside 3'-phosphotransferase aphA 0.0351
6029 Aminoglycoside 3'-phosphotransferase aphA1 0.0351
5646 Galactokinase GALK1 0.0351
5265 FtsH ftsH 0.0351
5302 TrwB trwB 0.0351
2810 Dr hemagglutinin structural subunit draA 0.0338
5287 Signaling protein Not Available 0.0315
5304 UPF0166 protein TM_0021 TM_0021 0.0315
5293 Shikimate kinase 2 aroL 0.0315
5288 Shikimate kinase aroK 0.0315
5314 UPF0079 ATP-binding protein HI0065 HI_0065 0.0315
3199 Phosphopantetheine adenylyltransferase coaD 0.0315
3543 Phosphopantetheine adenylyltransferase coaD 0.0315
3567 Phosphopantetheine adenylyltransferase coaD 0.0315
5289 Phosphopantetheine adenylyltransferase coaD 0.0315
5292 Putative partitioning protein TT_C1605 0.0315
5290 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0315
5638 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0315
2874 Nitrogenase iron protein 1 nifH1 0.0315
4346 Polynucleotide kinase pseT 0.0315
5283 D-alanine--D-alanine ligase B ddlB 0.0315
5270 ATP-dependent Clp protease ATP-binding subunit clpX clpX 0.0315
5266 Activator of hgdC 0.0315
5305 Phosphoribosylaminoimidazole carboxylase ATPase subunit purK 0.0315
5281 Plasmid segregation protein parM parM 0.0315
5276 Chromosomal replication initiator protein dnaA dnaA 0.0315
5299 D-alanine--D-alanine ligase ddl 0.0315
6598 D-alanine--D-alanine ligase ddl 0.0315
5259 Transcriptional regulator ntrC1 0.0315
6699 Transcriptional regulator Cgl2612 0.0315
5291 Glycogen synthase 1 glgA1 0.0315
5264 DNA replication protein REP 0.0315
5275 Multidrug resistance ABC transporter ATP-binding and permease protein lmrA 0.0315
4794 Phosphoenolpyruvate carboxykinase [ATP] pckA 0.0315
1549 Heat shock 70 kDa protein 1 HSPA1A 0.0315
5284 Large T antigen Not Available 0.0315
3777 ATP-dependent Clp protease ATP-binding subunit clpA clpA 0.0315
5315 Chaperone protein htpG htpG 0.0315
5285 Kinesin heavy chain KIF5B 0.0315
5277 Preprotein translocase subunit secA secA 0.0315
5308 Preprotein translocase secA 1 subunit secA1 0.0315
3982 Phosphoribosylformylglycinamidine synthase PFAS 0.0315
5261 Phosphoribosylformylglycinamidine synthase purL 0.0315
1673 GTP cyclohydrolase I GCH1 0.0313
3302 GTP cyclohydrolase I folE 0.0313
3209 Ornithine decarboxylase, inducible odcI 0.0313
2892 Acetylglutamate kinase argB 0.0306
3550 Acetylglutamate kinase argB 0.0306
2371 Pantothenate kinase coaA 0.0306
825 Arsenical pump-driving ATPase ASNA1 0.0306
3435 Arsenical pump-driving ATPase arsA 0.0306
2950 Inositol-trisphosphate 3-kinase A ITPKA 0.0306
1881 Hexokinase-1 HK1 0.0306
2417 Chloramphenicol acetyltransferase cat 0.0301
3278 Chloramphenicol acetyltransferase cat 0.0301
2727 S-adenosylmethionine synthetase metK 0.0292
6832 Serine/threonine-protein kinase SRPK2 SRPK2 0.0292
2270 Dephospho-CoA kinase coaE 0.0275
2284 Adenylate kinase adk 0.0274
2296 Adenylate kinase adk 0.0274
2311 Adenylate kinase adk 0.0274
2312 Adenylate kinase Not Available 0.0274
4106 Guanylate kinase GUK1 0.0274
4516 Guanylate kinase gmk 0.0274
3470 Hypothetical protein MG245 homolog MPN_348 0.0274
2751 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0274
4755 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0274
5295 2-keto-3-deoxy-gluconate kinase TT_P0036 0.0274
4774 NTPase P4 Not Available 0.0274
3426 Glutamine synthetase glnA 0.0274
3987 Glutamine synthetase GLUL 0.0274
413 Amidophosphoribosyltransferase PPAT 0.0274
2515 Amidophosphoribosyltransferase purF 0.0274
3714 Amidophosphoribosyltransferase purF 0.0274
3175 Glutamate--cysteine ligase gshA 0.0274
6277 Heat shock cognate 71 kDa protein HSPA8 0.0274
5189 Trimethylamine dehydrogenase tmd 0.0274
3335 Probable GTP-binding protein engB engB 0.0273
3354 Ras-related protein Rap-2a RAP2A 0.0273
3311 mRNA-capping enzyme A103R 0.0273
3085 Molybdopterin-guanine dinucleotide biosynthesis protein A mobA 0.0273
2647 RNA-directed RNA polymerase P2 0.0273
340 Apoptotic protease-activating factor 1 APAF1 0.027
2251 Thymidylate kinase tmk 0.0256
2254 Thymidylate kinase DTYMK 0.0256
3522 Thymidylate kinase tmk 0.0256
2390 Nonsecretory ribonuclease RNASE2 0.0253
2683 Mono-ADP-ribosyltransferase C3 C3 0.0253
2922 Glycerol kinase glpK 0.0253
5271 Focal adhesion kinase 1 PTK2 0.0253
2282 Protein recA recA 0.0251
2315 Protein recA recA 0.0251
2332 Protein recA recA 0.0251
5263 Protein recA recA 0.0251
207 Glutathione synthetase GSS 0.0247
5269 Glutathione synthetase gshB 0.0247
5300 Antigen peptide transporter 1 TAP1 0.0247
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0242
408 Riboflavin kinase RFK 0.0241
4366 Riboflavin kinase/FMN adenylyltransferase TM_0857 0.0239
6857 [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial PDK2 0.0239
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0239
3822 Actin, alpha skeletal muscle ACTA1 0.0238
1758 GTPase HRas HRAS 0.0227
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0226
788 Creatine kinase M-type CKM 0.0226
2697 Uridine-cytidine kinase 2 UCK2 0.022
2334 Dethiobiotin synthetase bioD 0.022
6555 Dethiobiotin synthetase bioD 0.022
1721 Glycogen synthase kinase-3 beta GSK3B 0.0219
61 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0214
2644 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0214
2710 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0214
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.0213
6316 ADP-ribosylation factor 1 ARF1 0.0213
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0208
702 UMP-CMP kinase CMPK1 0.0204
2317 UDP-N-acetylmuramoylalanine--D-glutamate ligase murD 0.0203
6395 Myosin-14 MYH14 0.0203
2091 Endoplasmin HSP90B1 0.0202
3978 Adenylosuccinate synthetase isozyme 1 ADSSL1 0.02
1422 Serine/threonine-protein kinase 6 AURKA 0.0195
3379 Kinesin-like protein KIF11 KIF11 0.0192
3456 Heat shock protein HSP 90-beta HSP90AB1 0.0189
504 Mast/stem cell growth factor receptor KIT 0.0182
509 Thymidine kinase TK 0.0178
570 Thymidine kinase TK 0.0178
2559 Thymidine kinase TK 0.0178
3430 Thymidine kinase tdk 0.0178
3518 Thymidine kinase TK 0.0178
5301 Thymidine kinase tdk 0.0178
5771 Thymidine kinase ORF36 0.0178
7009 Thymidine kinase ORF36 0.0178
5294 Nucleoside diphosphate kinase A NME1 0.0176
4773 Deoxycytidine kinase DCK 0.0166
2297 Genome polyprotein Not Available 0.0163
2322 Genome polyprotein Not Available 0.0163
2694 Genome polyprotein Not Available 0.0163
2719 Genome polyprotein Not Available 0.0163
2860 Genome polyprotein Not Available 0.0163
2928 Genome polyprotein Not Available 0.0163
3160 Genome polyprotein Not Available 0.0163
3260 Genome polyprotein Not Available 0.0163
4783 Genome polyprotein Not Available 0.0163
5726 Genome polyprotein Not Available 0.0163
5779 Genome polyprotein Not Available 0.0163
5867 Genome polyprotein Not Available 0.0163
6253 Genome polyprotein Not Available 0.0163
6301 Genome polyprotein Not Available 0.0163
6380 Genome polyprotein Not Available 0.0163
6381 Genome polyprotein Not Available 0.0163
6437 Genome polyprotein Not Available 0.0163
6520 Genome polyprotein Not Available 0.0163
6521 Genome polyprotein Not Available 0.0163
6652 Genome polyprotein Not Available 0.0163
6734 Genome polyprotein Not Available 0.0163
6735 Genome polyprotein Not Available 0.0163
6736 Genome polyprotein Not Available 0.0163
6737 Genome polyprotein Not Available 0.0163
6738 Genome polyprotein Not Available 0.0163
6739 Genome polyprotein Not Available 0.0163
6744 Genome polyprotein Not Available 0.0163
6748 Genome polyprotein Not Available 0.0163
6894 Genome polyprotein Not Available 0.0163
6898 Genome polyprotein Not Available 0.0163
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0163
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0163
5682 Ribonuclease pancreatic RNASE1 0.0159
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0146
1729 Solute carrier family 22 member 6 SLC22A6 0.0123
6107 Cytochrome P450 3A7 CYP3A7 0.0117
4924 Cytochrome P450 2C8 CYP2C8 0.0113
4118 Cytochrome P450 3A5 CYP3A5 0.0112
6016 Cytochrome P450 2C19 CYP2C19 0.0108
4757 Cytochrome P450 2C9 CYP2C9 0.0103
4512 Cytochrome P450 3A4 CYP3A4 0.0091
5641 Rod shape-determining protein MreB TM_0588 0.0088
4178 DNA repair protein RAD51 homolog 1 RAD51 0.0088
5645 DNA topoisomerase 4 subunit B parE 0.0088
6227 DNA topoisomerase 4 subunit B parE 0.0088
3794 Osmolarity sensor protein envZ envZ 0.0088
5644 Sensor protein phoQ phoQ 0.0088
5643 General secretion pathway protein E epsE 0.0088
5649 Potassium-transporting ATPase B chain kdpB 0.0088
5642 Chaperone clpB clpB 0.0088
4751 Mitogen-activated protein kinase 12 MAPK12 0.0077
2867 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase ispE 0.0077
2397 Dihydroxyacetone kinase dhaK 0.0077
740 Argininosuccinate synthase ASS1 0.0077
865 Argininosuccinate synthase ASS1 0.0077
2680 Argininosuccinate synthase argG 0.0077
3194 Argininosuccinate synthase argG 0.0077
2852 DNA mismatch repair protein mutL mutL 0.0077
4373 Medium-chain-fatty-acid--CoA ligase Not Available 0.0071
3231 Death-associated protein kinase 1 DAPK1 0.0071
936 Ephrin type-A receptor 2 EPHA2 0.0063
887 DNA gyrase subunit B gyrB 0.0063
4150 DNA gyrase subunit B gyrB 0.0063
6225 DNA gyrase subunit B gyrB 0.0063
958 Insulin-like growth factor 1 receptor IGF1R 0.0057
4192 DNA topoisomerase 2-beta TOP2B 0.0052
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0052
1836 Mitogen-activated protein kinase 10 MAPK10 0.005
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0048
2236 Casein kinase II subunit alpha CSNK2A1 0.0047
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