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Phosphoribosylglycinamide formyltransferase


Partner ID 2689
Name Phosphoribosylglycinamide formyltransferase
Synonyms 4618
Gene name purN
General function Nucleotide transport and metabolism
Specific function 10-formyltetrahydrofolate + 1-N-(5-phospho-D- ribosyl)glycinamide = tetrahydrofolate + 2-N-formyl-1-N-(5- phospho-D-ribosyl)glycinamide
Gene sequence + ...

ATGAATATTGTGGTGCTTATTTCCGGCAACGGAAGTAATTTACAGGCAATTATTGACGCCTGTAAAACCAACAAAATTAAAGGCACCGTACGGGCAGTTTTCAGCAATAAGGCCGACGCGTTCGGCCTTGAACGCGCCCGCCAGGCGGGTATTGCAACGCATACGCTCATCGCCAGCGCGTTTGACAGTCGTGAAGCCTATGACCGGGAGTTGATTCATGAAATCGACATGTACGCACCCGATGTGGTCGTGCTGGCTGGTTTTATGCGCATTCTCAGCCCGGCGTTTGTCTCCCACTATGCCGGGCGTTTGCTGAACATTCACCCTTCTCTGCTGCCGAAATATCCCGGATTACACACCCATCGTCAGGCGCTGGAAAATGGCGATGAAGAGCACGGTACATCGGTGCATTTCGTCACCGATGAACTGGACGGTGGCCCGGTTATTTTACAGGCGAAAGTCCCGGTATTTGCTGGTGATTCGGAAGATGACATCACCGCCCGCGTGCAAACCCAGGAACACGCCATTTATCCACTGGTGATTAGCTGGTTTGCCGATGGTCGTCTGAAAATGCACGAAAACGCCGCGTGGCTGGATGGTCAACGTCTGCCGCCGCAGGGCTACGCTGCCGACGAGTAA
Protein sequence + ...

MNIVVLISGNGSNLQAIIDACKTNKIKGTVRAVFSNKADAFGLERARQAGIATHTLIASAFDSREAYDRELIHEIDMYAPDVVVLAGFMRILSPAFVSHYAGRLLNIHPSLLPKYPGLHTHRQALENGDEEHGTSVHFVTDELDGGPVILQAKVPVFAGDSEDDITARVQTQEHAIYPLVISWFADGRLKMHENAAWLDGQRLPPQGYAADE
GO Classification
function
glycine hydroxymethyltransferase activity
catalytic activity
phosphoribosylglycinamide formyltransferase activity
hydroxymethyl-, formyl- and related transferase activity
transferase activity
transferase activity, transferring one-carbon groups
methyltransferase activity
process
nucleobase, nucleoside, nucleotide and nucleic acid metabolism
nucleotide metabolism
purine nucleoside monophosphate biosynthesis
purine ribonucleoside monophosphate biosynthesis
physiological process
purine nucleotide metabolism
purine nucleotide biosynthesis
metabolism
cellular metabolism
biosynthesis
IMP biosynthesis
'de novo' IMP biosynthesis
See more information at   →   www.drugbank.ca

Drugs


Associated as Target

Id Name
DB02236 Glycinamide Ribonucleotide
DB02540 (10S)-10-Formyl-5,8,10-Trideazafolic Acid
DB02794 N-[5'-O-Phosphono-Ribofuranosyl]-2-[2-Hydroxy-2-[4-[Glutamic Acid]-N-Carbonylphenyl]-3-[2-Amino-4-Hydroxy-Quinazolin-6-Yl]-Propanylamino]-Acetamide
DB04264 (10R)-10-Formyl-5,8,10-Trideazafolic Acid

Associated as Prediction

Id Name
DB00642 Pemetrexed
DB02236 Glycinamide Ribonucleotide
DB02540 (10S)-10-Formyl-5,8,10-Trideazafolic Acid
DB02794 N-[5'-O-Phosphono-Ribofuranosyl]-2-[2-Hydroxy-2-[4-[Glutamic Acid]-N-Carbonylphenyl]-3-[2-Amino-4-Hydroxy-Quinazolin-6-Yl]-Propanylamino]-Acetamide
DB02930 Phosphothiophosphoric Acid-Adenylate Ester
DB03431 Adenosine-5'-Diphosphate
DB03434 3[N-Morpholino]Propane Sulfonic Acid
DB03546 10-CF3C(OH)2-DDACTHF
DB03909 Adenosine-5'-[Beta, Gamma-Methylene]Triphosphate
DB04264 (10R)-10-Formyl-5,8,10-Trideazafolic Acid
DB04395 Phosphoaminophosphonic Acid-Adenylate Ester
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