DT-Web

DB00089 - Capromab


Identification
Name Capromab
Accession Number DB00089 (BIOD00080, BTD00080)
Type biotech
Description Murine IgG1 monoclonal antibody 7E11-C5.3 antibody conjugated to linker chelator peptide group for indium attachment
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight Not Available
Groups approved
Monoisotopic Weight Not Available
Pharmacology
Indication For diagnosis of prostate cancer and detection of intra-pelvic metastases.
Mechanism of action Binds selectively to cell-surface prostate-specific membrane antigen (PSMA) expressed on prostate tissues and tumors.
Absorption Not Available
Protein binding Not Available
Biotransformation Most likely removed by opsonization via the reticuloendothelial system or by human antimurine antibody production
Route of elimination Approximately 10% of the administered radioisotope dose is excreted in the urine during the 72 hours following intravenous infusion.
Toxicity Not Available
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Glutamate carboxypeptidase 2
Name Glutamate carboxypeptidase 2
Gene Name FOLH1
Pharmacological action yes
Actions other/unknown
References
  • Smith-Jones PM, Vallabahajosula S, Goldsmith SJ, Navarro V, Hunter CJ, Bastidas D, Bander NH: In vitro characterization of radiolabeled monoclonal antibodies specific for the extracellular domain of prostate-specific membrane antigen. Cancer Res. 2000 Sep 15;60(18):5237-43. - Pubmed
  • Sodee DB, Nelson AD, Faulhaber PF, Maclennan GT, Resnick MI, Bakale G: Update on fused capromab pendetide imaging of prostate cancer. Clin Prostate Cancer. 2005 Mar;3(4):230-8. - Pubmed
  • Gregorakis AK, Holmes EH, Murphy GP: Prostate-specific membrane antigen: current and future utility. Semin Urol Oncol. 1998 Feb;16(1):2-12. - Pubmed
  • Sodee DB, Ellis RJ, Samuels MA, Spirnak JP, Poole WF, Riester C, Martanovic DM, Stonecipher R, Bellon EM: Prostate cancer and prostate bed SPECT imaging with ProstaScint: semiquantitative correlation with prostatic biopsy results. Prostate. 1998 Nov 1;37(3):140-8. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 1.4208

Predictions


Id Partner name Gene Name Score
4026 Aspartyl aminopeptidase DNPEP 0.0068
4024 Mitochondrial glutamate carrier 2 SLC25A18 0.0068
4025 Mitochondrial glutamate carrier 1 SLC25A22 0.0068
4023 N-acetylglutamate synthase, mitochondrial NAGS 0.0068
1047 Excitatory amino acid transporter 2 SLC1A2 0.0068
4022 Glutamate--ammonia ligase domain-containing protein 1 LGSN 0.0068
4021 Probable glutamyl-tRNA synthetase, mitochondrial EARS2 0.0068
1912 Excitatory amino acid transporter 1 SLC1A3 0.0068
4016 Excitatory amino acid transporter 5 SLC1A7 0.0068
4019 Excitatory amino acid transporter 4 SLC1A6 0.0068
664 Glutamate decarboxylase 2 GAD2 0.0068
3890 Glutamate decarboxylase 2 GAD2 0.0068
920 Glutamate receptor, ionotropic kainate 5 GRIK5 0.0068
4020 Glutamyl aminopeptidase ENPEP 0.0068
915 Delta 1-pyrroline-5-carboxylate synthetase ALDH18A1 0.0068
4017 5-oxoprolinase OPLAH 0.0068
922 Glutamate receptor 4 GRIA4 0.0068
927 Metabotropic glutamate receptor 8 GRM8 0.0068
925 Metabotropic glutamate receptor 4 GRM4 0.0068
926 Metabotropic glutamate receptor 7 GRM7 0.0068
924 Glutamate receptor, ionotropic kainate 3 GRIK3 0.0068
919 Glutamate receptor, ionotropic kainate 4 GRIK4 0.0068
4018 Glutamate receptor delta-2 subunit GRID2 0.0068
4027 Glutamate receptor delta-1 subunit GRID1 0.0068
5 Glutaminase liver isoform, mitochondrial GLS2 0.0057
3984 Probable glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial PET112L 0.0057
917 Glutaminase kidney isoform, mitochondrial GLS 0.0057
355 GMP synthase [glutamine-hydrolyzing] GMPS 0.0057
4353 GMP synthase [glutamine-hydrolyzing] guaA 0.0057
3991 Glutamine-dependent NAD(+) synthetase NADSYN1 0.0057
668 Glutamate--cysteine ligase regulatory subunit GCLM 0.0057
3982 Phosphoribosylformylglycinamidine synthase PFAS 0.0057
5261 Phosphoribosylformylglycinamidine synthase purL 0.0057
665 Phosphoserine aminotransferase PSAT1 0.0055
4652 Phosphoserine aminotransferase serC 0.0055
801 Kynurenine/alpha-aminoadipate aminotransferase mitochondrial AADAT 0.0055
3895 Kynurenine--oxoglutarate transaminase 3 CCBL2 0.0055
420 Glutamate decarboxylase 1 GAD1 0.0055
3900 Glutamate decarboxylase 1 GAD1 0.0055
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.0054
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0054
916 Metabotropic glutamate receptor 1 GRM1 0.0053
923 Glutamate receptor 3 GRIA3 0.0052
1671 Excitatory amino acid transporter 3 SLC1A1 0.0051
83 Alpha-aminoadipic semialdehyde synthase, mitochondrial AASS 0.0051
210 Bifunctional aminoacyl-tRNA synthetase [Includes: Glutamyl-tRNA synthetase EPRS 0.005
186 Glutamate--cysteine ligase catalytic subunit GCLC 0.005
3877 Growth-inhibiting protein 18 GIG18 0.005
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0049
914 Formimidoyltransferase-cyclodeaminase FTCD 0.0049
426 Aspartate aminotransferase, mitochondrial GOT2 0.0049
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0048
763 Tyrosine aminotransferase TAT 0.0047
5493 Tyrosine aminotransferase Not Available 0.0047
735 Alanine aminotransferase 1 GPT 0.0047
3904 Alanine aminotransferase 2 GPT2 0.0047
586 Aspartate aminotransferase, cytoplasmic GOT1 0.0046
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0046
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0046
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0045
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0045
795 Branched-chain-amino-acid aminotransferase, mitochondrial BCAT2 0.0045
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0044
33 Cystine/glutamate transporter SLC7A11 0.0043
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0043
574 Branched-chain-amino-acid aminotransferase, cytosolic BCAT1 0.0043
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0041
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0041
705 Glutamate receptor 1 GRIA1 0.0041
3426 Glutamine synthetase glnA 0.0041
3987 Glutamine synthetase GLUL 0.0041
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.004
738 Monocarboxylate transporter 1 SLC16A1 0.0035
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0033
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0032
6151 Monocarboxylate transporter 10 SLC16A10 0.0032
921 Glutamate receptor 2 GRIA2 0.0031
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