DT-Web

DB03575 - Phencyclidine


Identification
Name Phencyclidine
Accession Number DB03575 (EXPT03307)
Type small molecule
Description A hallucinogen formerly used as a veterinary anesthetic, and briefly as a general anesthetic for humans. Phencyclidine is similar to ketamine in structure and in many of its effects. Like ketamine, it can produce a dissociative state. It exerts its pharmacological action through inhibition of NMDA receptors (receptors, N-methyl-D-aspartate). As a drug of abuse, it is known as PCP and Angel Dust. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 243.3871
Groups illicit
Monoisotopic Weight 243.198699805
Pharmacology
Indication Not Available
Mechanism of action The N-methyl-D-Aspartate (NMDA) receptor, a type of ionotropic receptor, is found on the dendrites of neurons and receives signals in the form of neurotransmitters. It is a major excitatory receptor in the brain. Normal physiological function requires that the activated receptor fluxes positive ions through the channel part of the receptor. PCP enters the ion channel from the outside of the neuron and binds, reversibly, to a site in the channel pore, blocking the flux of positive ions into the cell. PCP therefore inhibits depolarization of neurons and interferes with cognitive and other functions of the nervous system. [Wikipedia]
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Telithromycin Telithromycin may reduce clearance of Phencyclidine. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Phencyclidine if Telithromycin is initiated, discontinued or dose changed.
Voriconazole Voriconazole, a strong CYP3A4 inhibitor, may increase the serum concentration of phencyclidine by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of phencyclidine if voriconazole is initiated, discontinued or dose changed.
Food Interactions Not Available

Targets


Glutamate [NMDA] receptor subunit 3A
Name Glutamate [NMDA] receptor subunit 3A
Gene Name GRIN3A
Pharmacological action yes
Actions antagonist
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.2978
Sigma 1-type opioid receptor
Name Sigma 1-type opioid receptor
Gene Name SIGMAR1
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.4331

Enzymes


Cytochrome P450 2B6
Name Cytochrome P450 2B6
Gene Name CYP2B6
Actions inhibitor
References
  • Shebley M, Kent UM, Ballou DP, Hollenberg PF: Mechanistic analysis of the inactivation of cytochrome P450 2B6 by phencyclidine: effects on substrate binding, electron transfer, and uncoupling. Drug Metab Dispos. 2009 Apr;37(4):745-52. Epub 2009 Jan 14. - Pubmed
DTHybrid score 0.2573

Predictions


Id Partner name Gene Name Score
4512 Cytochrome P450 3A4 CYP3A4 0.0947
4119 Cytochrome P450 2D6 CYP2D6 0.0778
502 5-hydroxytryptamine 2A receptor HTR2A 0.0741
6016 Cytochrome P450 2C19 CYP2C19 0.0701
1256 5-hydroxytryptamine 6 receptor HTR6 0.0692
4757 Cytochrome P450 2C9 CYP2C9 0.067
847 Mu-type opioid receptor OPRM1 0.0658
696 Kappa-type opioid receptor OPRK1 0.0641
831 D(2) dopamine receptor DRD2 0.0616
6013 Cytochrome P450 2E1 CYP2E1 0.0532
4924 Cytochrome P450 2C8 CYP2C8 0.053
1588 Multidrug resistance protein 1 ABCB1 0.05
4200 Cytochrome P450 1A2 CYP1A2 0.0456
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0388
4118 Cytochrome P450 3A5 CYP3A5 0.0373
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0371
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0325
319 Opioid receptor, sigma 1 OPRS1 0.0322
3923 Cholinesterase BCHE 0.0321
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0321
6107 Cytochrome P450 3A7 CYP3A7 0.0321
5718 Cytochrome P450 2A6 CYP2A6 0.0315
341 5-hydroxytryptamine 3 receptor HTR3A 0.0294
638 D(3) dopamine receptor DRD3 0.0288
432 D(4) dopamine receptor DRD4 0.0283
824 Sodium-dependent serotonin transporter SLC6A4 0.0277
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0266
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.026
713 Sodium-dependent dopamine transporter SLC6A3 0.0257
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0251
6024 Cytochrome P450 1A1 CYP1A1 0.0189
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0185
4096 Metabotropic glutamate receptor 3 GRM3 0.0174
1362 Metabotropic glutamate receptor 2 GRM2 0.0174
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0174
6106 Cytochrome P450 2C18 CYP2C18 0.0167
103 Muscarinic acetylcholine receptor M1 CHRM1 0.016
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0158
916 Metabotropic glutamate receptor 1 GRM1 0.0157
2178 Metabotropic glutamate receptor 5 GRM5 0.0157
6144 Solute carrier family 22 member 2 SLC22A2 0.0153
492 Histamine H1 receptor HRH1 0.0153
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0144
587 Serum albumin ALB 0.0133
20 Prostaglandin G/H synthase 1 PTGS1 0.0127
482 Glycine receptor subunit alpha-1 GLRA1 0.0124
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0123
694 Matrix protein 2 M 0.0121
427 Substance-P receptor TACR1 0.012
593 Proton-coupled amino acid transporter 1 SLC36A1 0.0118
3811 Cytochrome P450 19A1 CYP19A1 0.0117
467 Delta-type opioid receptor OPRD1 0.0113
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0112
468 Cytochrome P450 4A11 CYP4A11 0.0111
6145 Solute carrier family 22 member 1 SLC22A1 0.0098
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0094
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0091
3939 Amine oxidase [flavin-containing] B MAOB 0.0091
3876 Aromatic-L-amino-acid decarboxylase DDC 0.009
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0089
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0085
590 5-hydroxytryptamine 2C receptor HTR2C 0.0078
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0078
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0077
537 ATP synthase delta chain, mitochondrial ATP5D 0.0074
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0073
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.007
465 Calmodulin CALM1 0.0067
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0067
251 Alcohol dehydrogenase 1A ADH1A 0.0066
862 Multidrug resistance-associated protein 1 ABCC1 0.0063
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0063
820 Glycine receptor subunit alpha-2 GLRA2 0.0062
122 P2Y purinoceptor 12 P2RY12 0.006
444 Alcohol dehydrogenase 1B ADH1B 0.0058
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0057
556 Alpha-1A adrenergic receptor ADRA1A 0.0053
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0052
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0052
1268 Neuropeptide S receptor NPSR1 0.0052
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0052
731 HIV-1 protease HIV-1 protease 0.0051
705 Glutamate receptor 1 GRIA1 0.005
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.005
4120 NADPH--cytochrome P450 reductase POR 0.005
517 Alcohol dehydrogenase 1C ADH1C 0.005
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.005
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0048
136 Estrogen receptor ESR1 0.0048
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0047
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0047
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0047
6073 Potassium channel subfamily K member 9 KCNK9 0.0047
6072 Potassium channel subfamily K member 3 KCNK3 0.0047
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0044
260 Cytochrome P450 51 ERG11 0.0044
761 Cytochrome P450 51 ERG11 0.0044
3163 Cytochrome P450 51 cyp51 0.0044
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0044
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0043
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0043
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0041
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0041
1898 Cytochrome P450 1B1 CYP1B1 0.0041
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.004
318 Alpha-2A adrenergic receptor ADRA2A 0.0039
776 Bile salt export pump ABCB11 0.0039
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0039
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0038
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0038
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0038
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0035
6147 Solute carrier family 22 member 3 SLC22A3 0.0035
118 Organic cation/carnitine transporter 2 SLC22A5 0.0034
2207 Rhodopsin RHO 0.0034
1656 CYP2B protein CYP2B 0.0034
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0034
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0034
6220 Aryl hydrocarbon receptor AHR 0.0033
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0033
818 50S ribosomal protein L10 rplJ 0.0032
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0032
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0031
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0031
146 Androgen receptor AR 0.003
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.003
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.003
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.003
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.003
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.003
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0029
504 Mast/stem cell growth factor receptor KIT 0.0029
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0028
3941 Amine oxidase [flavin-containing] A MAOA 0.0028
921 Glutamate receptor 2 GRIA2 0.0028
6142 Solute carrier family 22 member 8 SLC22A8 0.0027
6136 Multidrug resistance-associated protein 5 ABCC5 0.0027
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0027
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0027
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0027
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0026
1010 Cytochrome P450 51A1 CYP51A1 0.0026
4604 Liver carboxylesterase 1 CES1 0.0025
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0025
891 Dihydropteroate synthase folP 0.0025
5359 Dihydropteroate synthase folP 0.0025
7175 Dihydropteroate synthase sulI 0.0025
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0025
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0025
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0025
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0025
2164 Multidrug resistance-associated protein 4 ABCC4 0.0025
833 Organic cation/carnitine transporter 1 SLC22A4 0.0025
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0025
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0025
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0025
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0025
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0024
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0024
6137 Multidrug resistance-associated protein 6 ABCC6 0.0023
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0023
756 Sex hormone-binding globulin SHBG 0.0023
869 Estrogen receptor beta ESR2 0.0023
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0023
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0022
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0022
131 Synaptic vesicular amine transporter SLC18A2 0.0021
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0021
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0021
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.002
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.002
80 Peroxisome proliferator-activated receptor alpha PPARA 0.002
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.002
6020 Aldehyde oxidase AOX1 0.0019
3932 Glutathione S-transferase A2 GSTA2 0.0019
6138 Multidrug resistance protein 3 ABCB4 0.0019
563 Thyroid peroxidase TPO 0.0019
811 Translocator protein TSPO 0.0019
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0019
632 Alpha-1B adrenergic receptor ADRA1B 0.0019
1757 Myeloperoxidase MPO 0.0018
1262 Corticotropin-lipotropin POMC 0.0017
84 Nuclear receptor 0B1 NR0B1 0.0017
290 Prostaglandin G/H synthase 2 PTGS2 0.0017
6031 Cytochrome P450 3A43 CYP3A43 0.0016
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0016
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0015
26 Vascular endothelial growth factor receptor 3 FLT4 0.0015
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0015
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0015
581 Cytochrome P450 2R1 CYP2R1 0.0015
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0015
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0015
922 Glutamate receptor 4 GRIA4 0.0015
924 Glutamate receptor, ionotropic kainate 3 GRIK3 0.0015
919 Glutamate receptor, ionotropic kainate 4 GRIK4 0.0015
4024 Mitochondrial glutamate carrier 2 SLC25A18 0.0015
920 Glutamate receptor, ionotropic kainate 5 GRIK5 0.0015
4025 Mitochondrial glutamate carrier 1 SLC25A22 0.0015
4022 Glutamate--ammonia ligase domain-containing protein 1 LGSN 0.0015
4018 Glutamate receptor delta-2 subunit GRID2 0.0015
4027 Glutamate receptor delta-1 subunit GRID1 0.0015
1912 Excitatory amino acid transporter 1 SLC1A3 0.0015
4019 Excitatory amino acid transporter 4 SLC1A6 0.0015
4016 Excitatory amino acid transporter 5 SLC1A7 0.0015
4026 Aspartyl aminopeptidase DNPEP 0.0015
915 Delta 1-pyrroline-5-carboxylate synthetase ALDH18A1 0.0015
4021 Probable glutamyl-tRNA synthetase, mitochondrial EARS2 0.0015
4023 N-acetylglutamate synthase, mitochondrial NAGS 0.0015
1047 Excitatory amino acid transporter 2 SLC1A2 0.0015
664 Glutamate decarboxylase 2 GAD2 0.0015
3890 Glutamate decarboxylase 2 GAD2 0.0015
4017 5-oxoprolinase OPLAH 0.0015
927 Metabotropic glutamate receptor 8 GRM8 0.0015
925 Metabotropic glutamate receptor 4 GRM4 0.0015
926 Metabotropic glutamate receptor 7 GRM7 0.0015
4020 Glutamyl aminopeptidase ENPEP 0.0015
7 Nitric oxide synthase, inducible NOS2 0.0015
32 Vascular endothelial growth factor receptor 1 FLT1 0.0015
29 Tubulin beta-1 chain TUBB1 0.0014
161 Tubulin beta chain TUBB 0.0014
312 Tubulin beta chain TUB2 0.0014
124 Histamine H2 receptor HRH2 0.0014
1992 Vitamin D-binding protein GC 0.0014
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.0014
716 5-hydroxytryptamine 7 receptor HTR7 0.0014
6085 Fatty acid-binding protein, intestinal FABP2 0.0014
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0014
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0014
228 Beta platelet-derived growth factor receptor PDGFRB 0.0014
1729 Solute carrier family 22 member 6 SLC22A6 0.0014
1618 High affinity nerve growth factor receptor NTRK1 0.0013
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0013
789 Alpha-1D adrenergic receptor ADRA1D 0.0013
6014 Cytochrome P450 2A13 CYP2A13 0.0013
625 Glutamate carboxypeptidase 2 FOLH1 0.0013
1630 Integrin beta-2 ITGB2 0.0013
801 Kynurenine/alpha-aminoadipate aminotransferase mitochondrial AADAT 0.0013
665 Phosphoserine aminotransferase PSAT1 0.0013
4652 Phosphoserine aminotransferase serC 0.0013
3895 Kynurenine--oxoglutarate transaminase 3 CCBL2 0.0013
420 Glutamate decarboxylase 1 GAD1 0.0013
3900 Glutamate decarboxylase 1 GAD1 0.0013
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0013
738 Monocarboxylate transporter 1 SLC16A1 0.0013
3984 Probable glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial PET112L 0.0013
917 Glutaminase kidney isoform, mitochondrial GLS 0.0013
3991 Glutamine-dependent NAD(+) synthetase NADSYN1 0.0013
5 Glutaminase liver isoform, mitochondrial GLS2 0.0013
355 GMP synthase [glutamine-hydrolyzing] GMPS 0.0013
4353 GMP synthase [glutamine-hydrolyzing] guaA 0.0013
3982 Phosphoribosylformylglycinamidine synthase PFAS 0.0013
5261 Phosphoribosylformylglycinamidine synthase purL 0.0013
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0013
668 Glutamate--cysteine ligase regulatory subunit GCLM 0.0013
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0013
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0013
6143 Solute carrier family 22 member 7 SLC22A7 0.0013
6182 Cytochrome P450 2J2 CYP2J2 0.0013
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0012
94 5-hydroxytryptamine 4 receptor HTR4 0.0012
6432 Transporter snf 0.0012
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0012
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0012
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0012
923 Glutamate receptor 3 GRIA3 0.0012
407 Vascular endothelial growth factor receptor 2 KDR 0.0012
186 Glutamate--cysteine ligase catalytic subunit GCLC 0.0012
3877 Growth-inhibiting protein 18 GIG18 0.0012
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0012
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0012
763 Tyrosine aminotransferase TAT 0.0012
5493 Tyrosine aminotransferase Not Available 0.0012
1671 Excitatory amino acid transporter 3 SLC1A1 0.0012
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0011
914 Formimidoyltransferase-cyclodeaminase FTCD 0.0011
735 Alanine aminotransferase 1 GPT 0.0011
3904 Alanine aminotransferase 2 GPT2 0.0011
426 Aspartate aminotransferase, mitochondrial GOT2 0.0011
83 Alpha-aminoadipic semialdehyde synthase, mitochondrial AASS 0.0011
719 Retinoic acid receptor responder protein 1 RARRES1 0.0011
770 Retinoic acid-induced protein 3 GPRC5A 0.0011
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0011
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0011
210 Bifunctional aminoacyl-tRNA synthetase [Includes: Glutamyl-tRNA synthetase EPRS 0.0011
856 Vitamin D3 receptor VDR 0.0011
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0011
586 Aspartate aminotransferase, cytoplasmic GOT1 0.0011
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.001
844 Epidermal growth factor receptor EGFR 0.001
3426 Glutamine synthetase glnA 0.001
3987 Glutamine synthetase GLUL 0.001
33 Cystine/glutamate transporter SLC7A11 0.001
5798 Mitogen-activated protein kinase 11 MAPK11 0.001
3947 Xanthine dehydrogenase/oxidase XDH 0.001
795 Branched-chain-amino-acid aminotransferase, mitochondrial BCAT2 0.001
574 Branched-chain-amino-acid aminotransferase, cytosolic BCAT1 0.001
291 Nitric-oxide synthase, endothelial NOS3 0.001
23 D(1A) dopamine receptor DRD1 0.001
1353 DNA topoisomerase 1 TOP1 0.001
3552 DNA topoisomerase 1 topA 0.001
569 Retinal dehydrogenase 2 ALDH1A2 0.001
267 Plasminogen activator inhibitor 1 SERPINE1 0.001
611 Retinal dehydrogenase 1 ALDH1A1 0.0009
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0009
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0009
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0009
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0009
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0009
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0009
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0009
6221 Steroid hormone receptor ERR1 ESRRA 0.0009
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0009
5934 Cytochrome P450 26A1 CYP26A1 0.0009
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0009
751 Potassium channel subfamily K member 6 KCNK6 0.0008
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0008
1039 Histone deacetylase 9 HDAC9 0.0008
6148 Multidrug resistance-associated protein 7 ABCC10 0.0008
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0008
1360 Sphingomyelin phosphodiesterase SMPD1 0.0008
3937 Fatty-acid amide hydrolase FAAH 0.0008
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0008
780 Retinoic acid receptor RXR-gamma RXRG 0.0008
172 Potassium channel subfamily K member 1 KCNK1 0.0008
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0008
936 Ephrin type-A receptor 2 EPHA2 0.0008
6163 Copper-transporting ATPase 2 ATP7B 0.0008
6165 Copper-transporting ATPase 1 ATP7A 0.0008
5787 Angiopoietin-1 receptor TEK 0.0008
165 FL cytokine receptor FLT3 0.0008
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0008
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0008
823 Fibroblast growth factor receptor 2 FGFR2 0.0007
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0007
1192 Sulfotransferase 1A1 SULT1A1 0.0007
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0007
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0007
88 Retinoic acid receptor RXR-beta RXRB 0.0007
6146 High affinity copper uptake protein 1 SLC31A1 0.0007
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0007
6151 Monocarboxylate transporter 10 SLC16A10 0.0007
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0007
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0007
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0007
162 Retinoic acid receptor gamma-1 RARG 0.0007
6168 Solute carrier family 22 member 16 SLC22A16 0.0007
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0007
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0007
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0007
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0007
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0007
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0007
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0007
3809 Estrogen-related receptor gamma ESRRG 0.0007
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0007
908 Glutathione S-transferase theta-1 GSTT1 0.0007
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0007
469 Annexin A1 ANXA1 0.0007
284 DNA-directed RNA polymerase beta chain rpoB 0.0007
5773 DNA-directed RNA polymerase beta chain rpoB 0.0007
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0007
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0007
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0006
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0006
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0006
275 Arachidonate 5-lipoxygenase ALOX5 0.0006
896 Glutathione S-transferase Mu 1 GSTM1 0.0006
295 Carbonic anhydrase 1 CA1 0.0006
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0006
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0006
76 Nitric-oxide synthase, brain NOS1 0.0006
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0006
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0006
380 Cytochrome P450 17A1 CYP17A1 0.0006
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0006
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0006
904 Glutathione S-transferase P GSTP1 0.0006
2981 Phospholipase A2, membrane associated PLA2G2A 0.0005
6141 Sodium/bile acid cotransporter SLC10A1 0.0005
952 Dipeptidyl peptidase 4 DPP4 0.0005
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0005
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0005
817 DNA topoisomerase 2-alpha TOP2A 0.0005
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0005
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0005
373 Transthyretin TTR 0.0004
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0004
871 Glucocorticoid receptor NR3C1 0.0004
1024 Solute carrier family 22 member 11 SLC22A11 0.0004
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0004
193 Beta-1 adrenergic receptor ADRB1 0.0004
766 Beta-2 adrenergic receptor ADRB2 0.0004
320 5-hydroxytryptamine 1A receptor HTR1A 0.0003
4925 Cytochrome c-type protein SHP shp 0.0003
4954 Soluble cytochrome b558 Not Available 0.0003
4916 Cyanoglobin glbN 0.0003
4994 Hemoglobin-like protein HbO glbO 0.0003
4915 Cytochrome c-550 psbV 0.0003
4959 Cytochrome c-550 psbV 0.0003
5216 Cytochrome c-550 psbV 0.0003
4947 Bacterial hemoglobin vhb 0.0003
4975 Cytochrome c-556 RPA3973 0.0003
4984 Neuroglobin NGB 0.0003
4943 Cytochrome c6 petJ 0.0003
3116 Bacterioferritin bfr 0.0003
4906 Bacterioferritin bfr 0.0003
4965 Bacterioferritin bfr 0.0003
4934 Cytochrome c-551 nirM 0.0003
5218 Cytochrome c-551 nirM 0.0003
4905 Cytochrome c2 Not Available 0.0003
4939 Cytochrome c2 cycA 0.0003
4964 Cytochrome c2 cycA 0.0003
4979 Cytochrome c2 cycA 0.0003
6673 Cytochrome c2 cycA 0.0003
4910 Cytoglobin CYGB 0.0003
4907 Cytochrome c-L moxG 0.0003
6865 Cytochrome c-L moxG 0.0003
4981 Iron-starvation protein PigA pigA 0.0003
4936 Cytochrome c2 iso-2 Not Available 0.0003
4909 CooA protein cooA 0.0003
5000 HemO hemO 0.0003
4998 Hemoglobin-like protein yjbI yjbI 0.0003
644 Heme oxygenase 2 HMOX2 0.0003
4982 Heme oxygenase 2 pbsA2 0.0003
4942 Diheme cytochrome c napB napB 0.0003
4935 Cytochrome c-554 cycA1 0.0003
4972 P450cin cinA 0.0003
4971 Nonaheme cytochrome c hmcA 0.0003
4961 Hemophore HasA hasA 0.0003
4976 Apocytochrome f petA 0.0003
6407 Apocytochrome f petA 0.0003
4903 Methyl-accepting chemotaxis protein Tar4 0.0003
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0003
4999 Cytochrome P450 165B3 CYP165B3 0.0003
4764 Cytochrome P450 165C4 CYP165C4 0.0003
4960 Putative cytochrome P450-family protein SCO7417 0.0003
4931 Cytochrome P450 167A1 CYP167A1 0.0003
4926 Heme-based aerotactic transducer hemAT hemAT 0.0003
4904 Cytochrome c family protein GSU1996 0.0003
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0003
4937 Cytochrome oxidase subunit II rcoxA 0.0003
4993 Hydroxylamine oxidoreductase hao1 0.0003
4922 Cytochrome c, putative SO_4144 0.0003
4989 Cytochrome c551 peroxidase ccp 0.0003
5222 Cytochrome c551 peroxidase ccpA 0.0003
3093 Catalase HPII katE 0.0003
4952 Catalase/peroxidase katA 0.0003
4920 Peroxidase/catalase katG 0.0002
4948 Cytochrome c-553 Not Available 0.0002
4923 Cytochrome c3 DvMF_2499 0.0002
4945 Cytochrome c3 Not Available 0.0002
4949 Cytochrome c3 DVU_3171 0.0002
4968 Cytochrome c3 cytc3 0.0002
4997 Cytochrome c3 SO_2727 0.0002
5219 Cytochrome c3 cyd 0.0002
4902 Nine-heme cytochrome c Ddes_2038 0.0002
2119 Cytochrome b5 CYB5A 0.0002
3189 High-molecular-weight cytochrome c hmcA 0.0002
4990 PpcA ppcA 0.0002
3375 Acidic cytochrome c3 Not Available 0.0002
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0002
2915 Sensor protein fixL fixL 0.0002
4944 Sensor protein fixL fixL 0.0002
4988 Sulfite oxidase, mitochondrial SUOX 0.0002
4385 Cytochrome c' Not Available 0.0002
4967 Cytochrome c' cycA 0.0002
5038 Cytochrome c' Not Available 0.0002
5223 Cytochrome c' cycP 0.0002
3570 Cytochrome P450 152A1 cypC 0.0002
4813 Heme oxygenase hmuO 0.0002
5769 Heme oxygenase Not Available 0.0002
4037 Hypothetical protein GPX1 0.0002
4297 Hypothetical protein SP_1951 0.0002
4521 Hypothetical protein BC_2969 0.0002
4540 Hypothetical protein TM_1070 0.0002
4555 Hypothetical protein MT1739 0.0002
4569 Hypothetical protein mshD 0.0002
4578 Hypothetical protein PA3270 0.0002
4747 Hypothetical protein PA3967 0.0002
5177 Hypothetical protein TM_0096 0.0002
5194 Hypothetical protein PA1204 0.0002
5240 Hypothetical protein Rv2991 0.0002
5370 Hypothetical protein TM_1158 0.0002
5710 Hypothetical protein Tb927.5.1360 0.0002
4289 Cytochrome P450 TT_P0059 0.0002
6262 Cytochrome P450 staP 0.0002
4992 Cytochrome c peroxidase Not Available 0.0002
2230 Catalase CAT 0.0002
3249 Catalase katA 0.0002
3625 Catalase katA 0.0002
4539 Catalase katA 0.0002
4941 Catalase katB 0.0002
3411 Cytochrome P450 121 cyp121 0.0002
3670 Soluble cytochrome b562 precursor cybC 0.0002
3291 Cytochrome c-552 cycA 0.0002
4927 Cytochrome c-552 nrfA 0.0002
4938 Cytochrome c-552 cycA 0.0002
4953 Cytochrome c-552 nrfA 0.0002
5217 Cytochrome c-552 cycM 0.0002
2617 Nitric oxide synthase oxygenase nos 0.0002
2701 Nitric oxide synthase oxygenase nos 0.0002
4386 Hemoglobin-like protein HbN glbN 0.0002
3102 Flavohemoprotein hmp 0.0002
4969 Flavohemoprotein hmp 0.0002
518 Peroxidase/catalase T katG 0.0002
3127 Nitrite reductase nirS 0.0002
3284 Nitrite reductase nirS 0.0002
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0002
3221 Cytochrome c4 cc4 0.0002
2972 6-deoxyerythronolide B hydroxylase eryF 0.0002
605 Fumarate reductase flavoprotein subunit frdA 0.0002
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0002
3673 Fumarate reductase flavoprotein subunit fccA 0.0002
4912 Fumarate reductase flavoprotein subunit ifcA 0.0002
6549 Fumarate reductase flavoprotein subunit frdA 0.0002
4608 Putative cytochrome P450 SCO1207 0.0002
4963 Putative cytochrome P450 SCO2884 0.0002
6254 Putative cytochrome P450 SCO6998 0.0002
358 Cystathionine beta-synthase CBS 0.0002
1507 Cytochrome c CYCS 0.0002
693 Hemoglobin subunit beta HBB 0.0002
6268 Hydroxyacid oxidase 1 HAO1 0.0001
810 Heme oxygenase 1 HMOX1 0.0001
3391 Heme oxygenase 1 pbsA1 0.0001
2298 Cytochrome P450-cam camC 0.0001
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