DB00144 - Phosphatidylserine
| Identification | |
|---|---|
| Name | Phosphatidylserine |
| Accession Number | DB00144 (NUTR00048) |
| Type | small molecule |
| Description | Phosphatidylserine (PS) is a phospholipid nutrient found in fish, green leafy vegetables, soybeans and rice, and is essential for the normal functioning of neuronal cell membranes and activates Protein kinase C (PKC) which has been shown to be involved in memory function. In apoptosis, phosphatidylserine is transferred to the outer leaflet of the plasma membrane. This is part of the process by which the cell is targeted for phagocytosis. PS has been shown to slow cognitive decline in animal models. PS has been investigated in a small number of double-blind placebo trials and has been shown to increase memory performance in the elderly. Because of the potentail cognitive benefits of phosphatidylserine, the substance is sold as a dietary supplement to people who believe they can benefit from an increased intake. The dietary supplement was originally processed from bovine sources however Prion disease scares in the 1990s outlawed this process, and a soy-based alternative was adopted. |
| Structure |
|
| Categories (*) | |
| Molecular Weight | 385.3041 |
| Groups | approved |
| Monoisotopic Weight | 385.113782505 |
| Pharmacology | |
| Indication | Phosphatidylserine has demonstrated some usefulness in treating cognitive impairment, including Alzheimer's disease, age-associated memory impairment and some non-Alzheimer's dementias. More research is needed before phosphatidylserine can be indicated for immune enhancement or for reduction of exercise stress. |
| Mechanism of action | Cholinergic hypofunction is thought to account in part for the cognitive deficits found in Alzheimer's disease. The most commonly used drugs for the treatment of Alzheimer's disease are reversible acetylcholinesterase inhibitors. The rationale of these drugs is to increase acetylcholine levels in the brains of Alzheimer's patients, and they may be somewhat effective in some cases. Phosphatidylserine restores acetylcholine release in aging humans by maintaining an adequate supply of the molecule and is able to increase the availability of endogenous choline for de novo acetylcholine synthesis. The hippocampus of the brain is believed to be important for cognitive processes and is affected in those with Alzheimer's disease. The dendritic spines of pyramidal cells, the post-synaptic target of the excitatory input to the hippocampus, have been proposed as a substrate for information storage. Age-dependent dendritic spine loss in pyramidal neurons has been reported in the human brain, and the extent of synaptic loss appears to correlate with the degree of cognitive impairment. Phosphatidylserine treatment prevents the age-related reduction in dendritic spine density in rat hippocampus. Protein kinase C facilitation of acetylcholine release has been reported in rats. Phosphatidylserine was found to restore protein kinase C activity in aging rats. Stimulation of calcium uptake by brain synaptosomes and activation of protein kinase C are yet other speculative mechanisms of phosphatidylserine's putative cognition-enhancing action. |
| Absorption | Absorbed in the small intestine. |
| Protein binding | Not Available |
| Biotransformation | Following absorption, lysophosphatidylserine is metabolized in intestinal mucosa cells, and its metabolites, which include some phosphatidylserine, enter the lymphatics draining the small intestine. |
| Route of elimination | Not Available |
| Toxicity | There are no reports of overdosage. LD50 in rats is more than 5g/kg, and in rabbits is more than 2g/kg. |
| Affected organisms |
|
| Interactions | |
| Drug Interactions | Not Available |
| Food Interactions | Not Available |
Targets
| Diacylglycerol kinase gamma | |
|---|---|
| Name | Diacylglycerol kinase gamma |
| Gene Name | DGKG |
| Pharmacological action | unknown |
| Actions | Not Available |
| References |
|
| DTHybrid score | 1.6012 |
| Diacylglycerol kinase delta | |
| Name | Diacylglycerol kinase delta |
| Gene Name | DGKD |
| Pharmacological action | unknown |
| Actions | Not Available |
| References |
|
| DTHybrid score | 1.6009 |
| Phosphatidylserine synthase 2 | |
| Name | Phosphatidylserine synthase 2 |
| Gene Name | PTDSS2 |
| Pharmacological action | unknown |
| Actions | Not Available |
| References |
|
| DTHybrid score | 1.6015 |
| Sphingomyelin phosphodiesterase 4 | |
| Name | Sphingomyelin phosphodiesterase 4 |
| Gene Name | SMPD4 |
| Pharmacological action | unknown |
| Actions | Not Available |
| References |
|
| DTHybrid score | 1.601 |
| Sphingomyelin phosphodiesterase 3 | |
| Name | Sphingomyelin phosphodiesterase 3 |
| Gene Name | SMPD3 |
| Pharmacological action | unknown |
| Actions | Not Available |
| References |
|
| DTHybrid score | 1.6011 |
| Probable phospholipid-transporting ATPase IA | |
| Name | Probable phospholipid-transporting ATPase IA |
| Gene Name | ATP8A1 |
| Pharmacological action | unknown |
| Actions | Not Available |
| References |
|
| DTHybrid score | 1.6008 |
| Protein kinase C alpha type | |
| Name | Protein kinase C alpha type |
| Gene Name | PRKCA |
| Pharmacological action | unknown |
| Actions | Not Available |
| References |
|
| DTHybrid score | 1.097 |
| Phosphatidylserine synthase 1 | |
| Name | Phosphatidylserine synthase 1 |
| Gene Name | PTDSS1 |
| Pharmacological action | unknown |
| Actions | Not Available |
| References |
|
| DTHybrid score | 1.6015 |
| Phosphatidylserine decarboxylase proenzyme | |
| Name | Phosphatidylserine decarboxylase proenzyme |
| Gene Name | PISD |
| Pharmacological action | unknown |
| Actions | Not Available |
| References |
|
| DTHybrid score | 1.6014 |
| Scavenger receptor class B member 1 | |
| Name | Scavenger receptor class B member 1 |
| Gene Name | SCARB1 |
| Pharmacological action | unknown |
| Actions | Not Available |
| References |
|
| DTHybrid score | 1.6011 |