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DB04466 - SR12813


Identification
Name SR12813
Accession Number DB04466 (EXPT02953)
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 504.5336
Groups experimental
Monoisotopic Weight 504.240576722
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Nuclear receptor subfamily 1 group I member 2
Name Nuclear receptor subfamily 1 group I member 2
Gene Name NR1I2
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.2977

Predictions


Id Partner name Gene Name Score
284 DNA-directed RNA polymerase beta chain rpoB 0.0495
5773 DNA-directed RNA polymerase beta chain rpoB 0.0495
4512 Cytochrome P450 3A4 CYP3A4 0.0355
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0281
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.028
275 Arachidonate 5-lipoxygenase ALOX5 0.025
2907 Oxysterols receptor LXR-beta NR1H2 0.0242
6283 Oxysterols receptor LXR-alpha NR1H3 0.0242
1588 Multidrug resistance protein 1 ABCB1 0.0227
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0198
4924 Cytochrome P450 2C8 CYP2C8 0.0182
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0182
88 Retinoic acid receptor RXR-beta RXRB 0.0176
6228 Nuclear receptor coactivator 1 NCOA1 0.0173
6241 Nuclear receptor coactivator 2 NCOA2 0.0171
776 Bile salt export pump ABCB11 0.017
4200 Cytochrome P450 1A2 CYP1A2 0.0138
20 Prostaglandin G/H synthase 1 PTGS1 0.0134
136 Estrogen receptor ESR1 0.0126
1898 Cytochrome P450 1B1 CYP1B1 0.0126
6141 Sodium/bile acid cotransporter SLC10A1 0.0122
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0116
4118 Cytochrome P450 3A5 CYP3A5 0.0112
6016 Cytochrome P450 2C19 CYP2C19 0.0101
6030 Cytochrome P450 2B6 CYP2B6 0.0093
4077 Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform PPP2CB 0.0087
86 SEC14-like protein 4 SEC14L4 0.0087
375 SEC14-like protein 3 SEC14L3 0.0087
4076 Diacylglycerol kinase alpha DGKA 0.0087
844 Epidermal growth factor receptor EGFR 0.0086
708 Alpha-tocopherol transfer protein TTPA 0.0082
283 SEC14-like protein 2 SEC14L2 0.0081
6148 Multidrug resistance-associated protein 7 ABCC10 0.0078
4078 Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform PPP2CA 0.0077
997 Protein kinase C beta type PRKCB 0.0077
6107 Cytochrome P450 3A7 CYP3A7 0.0074
899 Glutathione S-transferase Mu 3 GSTM3 0.0072
905 Glutathione transferase omega-1 GSTO1 0.0072
5923 Microtubule-associated protein tau MAPT 0.0071
5924 Microtubule-associated protein 4 MAP4 0.007
1970 Protein kinase C alpha type PRKCA 0.007
6024 Cytochrome P450 1A1 CYP1A1 0.0069
1852 Microtubule-associated protein 2 MAP2 0.0066
587 Serum albumin ALB 0.0066
186 Glutamate--cysteine ligase catalytic subunit GCLC 0.0065
862 Multidrug resistance-associated protein 1 ABCC1 0.0064
4757 Cytochrome P450 2C9 CYP2C9 0.0064
810 Heme oxygenase 1 HMOX1 0.0063
3391 Heme oxygenase 1 pbsA1 0.0063
273 Apoptosis regulator Bcl-2 BCL2 0.0061
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0061
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0059
29 Tubulin beta-1 chain TUBB1 0.0059
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0056
3932 Glutathione S-transferase A2 GSTA2 0.0056
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0053
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0053
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0051
904 Glutathione S-transferase P GSTP1 0.005
6085 Fatty acid-binding protein, intestinal FABP2 0.0041
3811 Cytochrome P450 19A1 CYP19A1 0.004
6031 Cytochrome P450 3A43 CYP3A43 0.0037
468 Cytochrome P450 4A11 CYP4A11 0.0037
4119 Cytochrome P450 2D6 CYP2D6 0.0037
756 Sex hormone-binding globulin SHBG 0.0035
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0034
6136 Multidrug resistance-associated protein 5 ABCC5 0.0034
869 Estrogen receptor beta ESR2 0.0032
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0031
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0031
6143 Solute carrier family 22 member 7 SLC22A7 0.0029
6147 Solute carrier family 22 member 3 SLC22A3 0.0027
1024 Solute carrier family 22 member 11 SLC22A11 0.0026
5718 Cytochrome P450 2A6 CYP2A6 0.0026
6144 Solute carrier family 22 member 2 SLC22A2 0.0024
6145 Solute carrier family 22 member 1 SLC22A1 0.0023
6013 Cytochrome P450 2E1 CYP2E1 0.0023
6142 Solute carrier family 22 member 8 SLC22A8 0.0023
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