DT-Web

DB01221 - Ketamine


Identification
Name Ketamine
Accession Number DB01221 (APRD00493)
Type small molecule
Description A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can block NMDA receptors (receptors, N-methyl-D-aspartate) and may interact with sigma receptors. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 237.725
Groups approved
Monoisotopic Weight 237.092041846
Pharmacology
Indication For use as the sole anesthetic agent for diagnostic and surgical procedures that do not require skeletal muscle relaxation.
Mechanism of action Ketamine has several clinically useful properties, including analgesia and less cardiorespiratory depressant effects than other anaesthetic agents, it also causes some stimulation of the cardiocascular system. Ketamine has been reported to produce general as well as local anaesthesia. It interacts with N-methyl-D-aspartate (NMDA) receptors, opioid receptors, monoaminergic receptors, muscarinic receptors and voltage sensitive Ca ion channels. Unlike other general anaesthetic agents, ketamine does not interact with GABA receptors.
Absorption Rapidly absorbed following parenteral administration.
Protein binding Not Available
Biotransformation Hepatic.
Route of elimination Not Available
Toxicity Not Available
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Memantine Increased risk of CNS adverse effects with this association
Telithromycin Telithromycin may reduce clearance of Ketamine. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Ketamine if Telithromycin is initiated, discontinued or dose changed.
Thiotepa Thiotepa, a strong CYP2B6 inhibitor, may decrease the metabolism and clearance of Ketamine, a CYP2B6 substrate. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of Ketamine if Thiotepa is initiated, discontinued or dose changed.
Tolbutamide Tolbutamide, a strong CYP2C9 inhibitor, may decrease the metabolism and clearance of Ketamine. Consider alternate therapy or monitor for changes in Ketamine therapeutic and adverse effects if Tolbutamide is initiated, discontinued or dose changed.
Voriconazole Voriconazole, a strong CYP3A4 inhibitor, may increase the serum concentration of ketamine by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of ketamine if voriconazole is initiated, discontinued or dose changed.
Food Interactions Not Available

Targets


Glutamate [NMDA] receptor subunit 3A
Name Glutamate [NMDA] receptor subunit 3A
Gene Name GRIN3A
Pharmacological action yes
Actions antagonist
References
  • Smothers CT, Woodward JJ: Pharmacological characterization of glycine-activated currents in HEK 293 cells expressing N-methyl-D-aspartate NR1 and NR3 subunits. J Pharmacol Exp Ther. 2007 Aug;322(2):739-48. Epub 2007 May 14. - Pubmed
  • Harrison NL, Simmonds MA: Quantitative studies on some antagonists of N-methyl D-aspartate in slices of rat cerebral cortex. Br J Pharmacol. 1985 Feb;84(2):381-91. - Pubmed
  • Sinner B, Graf BM: Ketamine. Handb Exp Pharmacol. 2008;(182):313-33. - Pubmed
  • Radovanovic D, Pjevic M: [Ketamine: the past 30 years and its future] Med Pregl. 2003 Sep-Oct;56(9-10):439-45. - Pubmed
DTHybrid score 0.2822
Substance-P receptor
Name Substance-P receptor
Gene Name TACR1
Pharmacological action unknown
Actions antagonist
References
  • Okamoto T, Minami K, Uezono Y, Ogata J, Shiraishi M, Shigematsu A, Ueta Y: The inhibitory effects of ketamine and pentobarbital on substance p receptors expressed in Xenopus oocytes. Anesth Analg. 2003 Jul;97(1):104-10, table of contents. - Pubmed
DTHybrid score 0.332
D(2) dopamine receptor
Name D(2) dopamine receptor
Gene Name DRD2
Pharmacological action unknown
Actions agonist,partial agonist
References
  • Seeman P, Guan HC, Hirbec H: Dopamine D2High receptors stimulated by phencyclidines, lysergic acid diethylamide, salvinorin A, and modafinil. Synapse. 2009 Aug;63(8):698-704. - Pubmed
DTHybrid score 0.3028

Enzymes


Cytochrome P450 2C9
Name Cytochrome P450 2C9
Gene Name CYP2C9
Actions substrate
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.5045
Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.6243
Cytochrome P450 2B6
Name Cytochrome P450 2B6
Gene Name CYP2B6
Actions substrate
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3496
Prostaglandin G/H synthase 1
Name Prostaglandin G/H synthase 1
Gene Name PTGS1
Actions substrate
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
DTHybrid score 0.4815
Cytochrome P450 2C8
Name Cytochrome P450 2C8
Gene Name CYP2C8
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.362

Transporters


Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions inhibitor
References
  • Mahar Doan KM, Humphreys JE, Webster LO, Wring SA, Shampine LJ, Serabjit-Singh CJ, Adkison KK, Polli JW: Passive permeability and P-glycoprotein-mediated efflux differentiate central nervous system (CNS) and non-CNS marketed drugs. J Pharmacol Exp Ther. 2002 Dec;303(3):1029-37. - Pubmed
DTHybrid score 0.4071

Predictions


Id Partner name Gene Name Score
6016 Cytochrome P450 2C19 CYP2C19 0.3097
4119 Cytochrome P450 2D6 CYP2D6 0.3007
4200 Cytochrome P450 1A2 CYP1A2 0.2553
4118 Cytochrome P450 3A5 CYP3A5 0.213
290 Prostaglandin G/H synthase 2 PTGS2 0.1787
6107 Cytochrome P450 3A7 CYP3A7 0.1617
6013 Cytochrome P450 2E1 CYP2E1 0.1498
3872 Somatostatin receptor type 5 SSTR5 0.1385
6008 Somatostatin receptor type 2 SSTR2 0.1385
587 Serum albumin ALB 0.1165
502 5-hydroxytryptamine 2A receptor HTR2A 0.1062
5718 Cytochrome P450 2A6 CYP2A6 0.1014
23 D(1A) dopamine receptor DRD1 0.0947
6024 Cytochrome P450 1A1 CYP1A1 0.0911
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0835
556 Alpha-1A adrenergic receptor ADRA1A 0.0693
492 Histamine H1 receptor HRH1 0.0662
6106 Cytochrome P450 2C18 CYP2C18 0.0637
1729 Solute carrier family 22 member 6 SLC22A6 0.0631
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0619
3923 Cholinesterase BCHE 0.0609
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0605
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0598
638 D(3) dopamine receptor DRD3 0.0566
320 5-hydroxytryptamine 1A receptor HTR1A 0.0534
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0529
824 Sodium-dependent serotonin transporter SLC6A4 0.0528
590 5-hydroxytryptamine 2C receptor HTR2C 0.0513
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0502
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0501
6145 Solute carrier family 22 member 1 SLC22A1 0.0493
862 Multidrug resistance-associated protein 1 ABCC1 0.0487
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0487
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0486
174 Sigma 1-type opioid receptor SIGMAR1 0.0473
341 5-hydroxytryptamine 3 receptor HTR3A 0.0461
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0454
3811 Cytochrome P450 19A1 CYP19A1 0.044
318 Alpha-2A adrenergic receptor ADRA2A 0.0438
6144 Solute carrier family 22 member 2 SLC22A2 0.0423
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0419
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0413
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0413
432 D(4) dopamine receptor DRD4 0.0409
713 Sodium-dependent dopamine transporter SLC6A3 0.0405
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0405
632 Alpha-1B adrenergic receptor ADRA1B 0.0401
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0381
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0377
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0372
136 Estrogen receptor ESR1 0.0351
847 Mu-type opioid receptor OPRM1 0.0348
6142 Solute carrier family 22 member 8 SLC22A8 0.0347
2164 Multidrug resistance-associated protein 4 ABCC4 0.0329
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0326
1898 Cytochrome P450 1B1 CYP1B1 0.0325
467 Delta-type opioid receptor OPRD1 0.0323
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0322
275 Arachidonate 5-lipoxygenase ALOX5 0.032
163 D(1B) dopamine receptor DRD5 0.0318
871 Glucocorticoid receptor NR3C1 0.0318
776 Bile salt export pump ABCB11 0.031
629 Alpha-2B adrenergic receptor ADRA2B 0.0308
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0303
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0298
465 Calmodulin CALM1 0.0296
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0294
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0289
378 Alpha-2C adrenergic receptor ADRA2C 0.0285
725 5-hydroxytryptamine 1D receptor HTR1D 0.0279
436 5-hydroxytryptamine 2B receptor HTR2B 0.0277
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0277
696 Kappa-type opioid receptor OPRK1 0.0276
885 5-hydroxytryptamine 1B receptor HTR1B 0.0269
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0264
731 HIV-1 protease HIV-1 protease 0.0264
716 5-hydroxytryptamine 7 receptor HTR7 0.0264
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0261
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0251
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.025
6143 Solute carrier family 22 member 7 SLC22A7 0.025
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.025
789 Alpha-1D adrenergic receptor ADRA1D 0.0247
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0237
260 Cytochrome P450 51 ERG11 0.0235
761 Cytochrome P450 51 ERG11 0.0235
3163 Cytochrome P450 51 cyp51 0.0235
468 Cytochrome P450 4A11 CYP4A11 0.0233
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0232
122 P2Y purinoceptor 12 P2RY12 0.0229
3939 Amine oxidase [flavin-containing] B MAOB 0.0229
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0226
118 Organic cation/carnitine transporter 2 SLC22A5 0.0218
1024 Solute carrier family 22 member 11 SLC22A11 0.0217
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0217
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0214
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0212
70 Type-1 angiotensin II receptor AGTR1 0.0203
3876 Aromatic-L-amino-acid decarboxylase DDC 0.02
891 Dihydropteroate synthase folP 0.019
5359 Dihydropteroate synthase folP 0.019
7175 Dihydropteroate synthase sulI 0.019
766 Beta-2 adrenergic receptor ADRB2 0.0185
3941 Amine oxidase [flavin-containing] A MAOA 0.0183
146 Androgen receptor AR 0.0181
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0181
1757 Myeloperoxidase MPO 0.0178
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0177
4096 Metabotropic glutamate receptor 3 GRM3 0.0174
1362 Metabotropic glutamate receptor 2 GRM2 0.0174
694 Matrix protein 2 M 0.0172
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0172
6182 Cytochrome P450 2J2 CYP2J2 0.0171
811 Translocator protein TSPO 0.0169
2178 Metabotropic glutamate receptor 5 GRM5 0.0167
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0166
193 Beta-1 adrenergic receptor ADRB1 0.0164
6147 Solute carrier family 22 member 3 SLC22A3 0.0163
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0162
482 Glycine receptor subunit alpha-1 GLRA1 0.016
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.016
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0157
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0157
916 Metabotropic glutamate receptor 1 GRM1 0.0157
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0153
4604 Liver carboxylesterase 1 CES1 0.0153
6137 Multidrug resistance-associated protein 6 ABCC6 0.0149
6031 Cytochrome P450 3A43 CYP3A43 0.0149
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0149
4120 NADPH--cytochrome P450 reductase POR 0.0148
504 Mast/stem cell growth factor receptor KIT 0.0147
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0147
817 DNA topoisomerase 2-alpha TOP2A 0.0145
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0145
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0144
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0144
373 Transthyretin TTR 0.0142
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0142
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0139
614 Progesterone receptor PGR 0.0137
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0136
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0136
380 Cytochrome P450 17A1 CYP17A1 0.0136
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0135
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0134
869 Estrogen receptor beta ESR2 0.0133
6102 Arylamine N-acetyltransferase 2 NAT2 0.0132
6136 Multidrug resistance-associated protein 5 ABCC5 0.013
6085 Fatty acid-binding protein, intestinal FABP2 0.0129
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0129
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0129
6141 Sodium/bile acid cotransporter SLC10A1 0.0129
844 Epidermal growth factor receptor EGFR 0.0128
319 Opioid receptor, sigma 1 OPRS1 0.0126
738 Monocarboxylate transporter 1 SLC16A1 0.0123
921 Glutamate receptor 2 GRIA2 0.0123
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0123
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0123
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0121
1256 5-hydroxytryptamine 6 receptor HTR6 0.0121
29 Tubulin beta-1 chain TUBB1 0.0121
833 Organic cation/carnitine transporter 1 SLC22A4 0.0121
6148 Multidrug resistance-associated protein 7 ABCC10 0.012
158 Sodium channel protein type 1 subunit alpha SCN1A 0.012
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.012
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.012
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0119
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0119
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0118
593 Proton-coupled amino acid transporter 1 SLC36A1 0.0118
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0118
818 50S ribosomal protein L10 rplJ 0.0117
1507 Cytochrome c CYCS 0.0117
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0115
756 Sex hormone-binding globulin SHBG 0.0113
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0113
952 Dipeptidyl peptidase 4 DPP4 0.0111
124 Histamine H2 receptor HRH2 0.0111
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0111
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.011
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0109
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0109
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0109
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0109
185 Vasopressin V1a receptor AVPR1A 0.0106
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0106
94 5-hydroxytryptamine 4 receptor HTR4 0.0105
161 Tubulin beta chain TUBB 0.0105
312 Tubulin beta chain TUB2 0.0105
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0105
407 Vascular endothelial growth factor receptor 2 KDR 0.0105
322 Vasopressin V2 receptor AVPR2 0.0104
2183 Fatty acid-binding protein, adipocyte FABP4 0.0103
474 Acetylcholinesterase ACHE 0.0102
777 Tumor necrosis factor TNF 0.0102
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0102
1192 Sulfotransferase 1A1 SULT1A1 0.0101
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.01
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0099
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0099
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0099
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0099
131 Synaptic vesicular amine transporter SLC18A2 0.0099
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0098
4116 Dihydropteroate synthetase Not Available 0.0097
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0097
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0096
528 5-hydroxytryptamine 1E receptor HTR1E 0.0093
228 Beta platelet-derived growth factor receptor PDGFRB 0.0093
537 ATP synthase delta chain, mitochondrial ATP5D 0.0092
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0091
232 Corticosteroid-binding globulin SERPINA6 0.0091
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0091
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0091
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0091
26 Vascular endothelial growth factor receptor 3 FLT4 0.009
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.009
1656 CYP2B protein CYP2B 0.009
365 Dihydrofolate reductase DHFR 0.009
2381 Dihydrofolate reductase DFR1 0.009
2833 Dihydrofolate reductase Not Available 0.009
2931 Dihydrofolate reductase folA 0.009
3544 Dihydrofolate reductase folA 0.009
3682 Dihydrofolate reductase folA 0.009
6642 Dihydrofolate reductase folA 0.009
6756 Dihydrofolate reductase dfrA 0.009
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0089
3947 Xanthine dehydrogenase/oxidase XDH 0.0089
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0088
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0088
1010 Cytochrome P450 51A1 CYP51A1 0.0087
32 Vascular endothelial growth factor receptor 1 FLT1 0.0087
6138 Multidrug resistance protein 3 ABCB4 0.0086
3312 Fatty acid-binding protein, brain FABP7 0.0086
923 Glutamate receptor 3 GRIA3 0.0086
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0085
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0085
6220 Aryl hydrocarbon receptor AHR 0.0084
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0084
4148 Serine/threonine-protein kinase mTOR MTOR 0.0083
6014 Cytochrome P450 2A13 CYP2A13 0.0082
737 Mineralocorticoid receptor NR3C2 0.0082
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0082
1648 Elastin ELN 0.0081
705 Glutamate receptor 1 GRIA1 0.0081
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0081
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0081
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0079
68 Cannabinoid receptor 1 CNR1 0.0079
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0078
3810 Catechol O-methyltransferase COMT 0.0078
1629 Transcription factor AP-1 JUN 0.0078
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0078
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0077
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0077
295 Carbonic anhydrase 1 CA1 0.0077
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0076
24 Thymidylate synthase TMP1 0.0076
359 Thymidylate synthase TYMS 0.0076
2626 Thymidylate synthase thyA 0.0076
2729 Thymidylate synthase thyA 0.0076
5352 Thymidylate synthase THYA 0.0076
251 Alcohol dehydrogenase 1A ADH1A 0.0075
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0075
1541 Metalloproteinase mmp20 0.0074
7 Nitric oxide synthase, inducible NOS2 0.0074
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0073
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0073
1353 DNA topoisomerase 1 TOP1 0.0072
3552 DNA topoisomerase 1 topA 0.0072
88 Retinoic acid receptor RXR-beta RXRB 0.0072
130 Prostacyclin synthase PTGIS 0.0072
820 Glycine receptor subunit alpha-2 GLRA2 0.0071
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0071
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0071
444 Alcohol dehydrogenase 1B ADH1B 0.007
558 Solute carrier family 12 member 1 SLC12A1 0.007
6020 Aldehyde oxidase AOX1 0.007
49 Endothelin B receptor EDNRB 0.0069
6043 Putative G-protein coupled receptor 44 GPR44 0.0069
2207 Rhodopsin RHO 0.0069
244 Angiotensin-converting enzyme ACE 0.0068
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0068
592 Carbonic anhydrase 4 CA4 0.0067
823 Fibroblast growth factor receptor 2 FGFR2 0.0066
6103 Arylamine N-acetyltransferase 1 NAT1 0.0065
578 Endothelin-1 receptor EDNRA 0.0065
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0065
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0065
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0064
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0064
3432 Multidrug-efflux transporter 1 regulator bmrR 0.0063
4476 Mannitol dehydrogenase mtlD 0.0063
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0063
133 Dihydropterate synthase sulI 0.0063
4237 50S ribosomal protein L22 rplV 0.0062
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0062
1618 High affinity nerve growth factor receptor NTRK1 0.0062
4203 Histamine N-methyltransferase HNMT 0.0061
1275 Estrogen sulfotransferase SULT1E1 0.0061
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0061
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.006
4103 Proteasome subunit beta type 2 PSMB2 0.006
4102 Proteasome subunit beta type 5 PSMB5 0.006
4101 Proteasome subunit beta type 1 PSMB1 0.006
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.006
723 Cytosolic phospholipase A2 PLA2G4A 0.006
3932 Glutathione S-transferase A2 GSTA2 0.006
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.006
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.006
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.006
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.006
1268 Neuropeptide S receptor NPSR1 0.006
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.006
517 Alcohol dehydrogenase 1C ADH1C 0.0059
856 Vitamin D3 receptor VDR 0.0059
1050 Bile salt sulfotransferase SULT2A1 0.0059
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0058
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0058
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0058
459 Retinoic acid receptor RXR-alpha RXRA 0.0058
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0057
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0057
2449 Tubulin alpha-3 chain TUBA1A 0.0056
703 NADPH azoreductase azr 0.0056
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0055
780 Retinoic acid receptor RXR-gamma RXRG 0.0055
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0055
814 Ryanodine receptor 1 RYR1 0.0055
477 DNA topoisomerase 4 subunit A parC 0.0054
886 DNA topoisomerase 4 subunit A parC 0.0054
6226 DNA topoisomerase 4 subunit A parC 0.0054
6073 Potassium channel subfamily K member 9 KCNK9 0.0054
6072 Potassium channel subfamily K member 3 KCNK3 0.0054
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0054
6149 Solute carrier family 22 member 10 SLC22A10 0.0053
404 DNA gyrase subunit A gyrA 0.0053
6224 DNA gyrase subunit A gyrA 0.0053
1852 Microtubule-associated protein 2 MAP2 0.0053
6859 Protein S100-A4 S100A4 0.0053
850 Vasopressin V1b receptor AVPR1B 0.0053
2853 14 kDa fatty acid-binding protein Not Available 0.0053
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0052
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0051
2539 Tubulin alpha-1 chain TUBA4A 0.0051
106 Cannabinoid receptor 2 CNR2 0.0051
2499 Tubulin beta-2C chain TUBB2C 0.0051
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.005
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.005
183 Vascular endothelial growth factor A VEGFA 0.005
634 Squalene monooxygenase SQLE 0.005
7196 Squalene monooxygenase ERG1 0.005
357 Carbonic anhydrase 2 CA2 0.005
5300 Antigen peptide transporter 1 TAP1 0.005
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.005
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0049
1178 Adenosine A2a receptor ADORA2A 0.0049
6033 High affinity interleukin-8 receptor A CXCR1 0.0049
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0049
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0049
581 Cytochrome P450 2R1 CYP2R1 0.0048
273 Apoptosis regulator Bcl-2 BCL2 0.0048
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0048
6146 High affinity copper uptake protein 1 SLC31A1 0.0048
84 Nuclear receptor 0B1 NR0B1 0.0048
904 Glutathione S-transferase P GSTP1 0.0048
165 FL cytokine receptor FLT3 0.0048
4238 50S ribosomal protein L4 rplD 0.0047
5578 50S ribosomal protein L4 rplD 0.0047
6173 50S ribosomal protein L4 rplD 0.0047
6219 50S ribosomal protein L4 rplD 0.0047
3809 Estrogen-related receptor gamma ESRRG 0.0047
284 DNA-directed RNA polymerase beta chain rpoB 0.0047
5773 DNA-directed RNA polymerase beta chain rpoB 0.0047
162 Retinoic acid receptor gamma-1 RARG 0.0047
2616 Ganglioside GM2 activator GM2A 0.0047
2981 Phospholipase A2, membrane associated PLA2G2A 0.0047
683 Potassium transporter GK0582 0.0047
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0046
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0046
6012 Tryptophan 2,3-dioxygenase TDO2 0.0045
54 Prothrombin F2 0.0045
239 Coagulation factor X F10 0.0045
527 Prostacyclin receptor PTGIR 0.0045
469 Annexin A1 ANXA1 0.0045
489 Monocarboxylate transporter 2 SLC16A7 0.0044
208 DNA-directed RNA polymerase beta' chain rpoC 0.0044
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0044
1262 Corticotropin-lipotropin POMC 0.0044
3808 Dihydropteroate synthase 2 folP2 0.0044
3601 Dihydropteroate synthase 1 folP1 0.0044
3807 Dihydropteroate synthase 1 folP1 0.0044
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0043
5787 Angiopoietin-1 receptor TEK 0.0043
153 Dopamine beta-hydroxylase DBH 0.0043
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0043
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0042
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0042
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0042
6174 50S ribosomal protein L32 rpmF 0.0042
768 FK506-binding protein 1A FKBP1A 0.0042
4122 Histone deacetylase 2 HDAC2 0.0041
16 Adenosine A1 receptor ADORA1 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
1630 Integrin beta-2 ITGB2 0.004
511 5-hydroxytryptamine 1F receptor HTR1F 0.004
4132 Chloride channel protein ClC-Ka CLCNKA 0.0039
33 Cystine/glutamate transporter SLC7A11 0.0039
518 Peroxidase/catalase T katG 0.0039
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
571 Melatonin receptor type 1A MTNR1A 0.0038
362 Melatonin receptor type 1B MTNR1B 0.0038
3856 Fibroblast growth factor receptor 3 FGFR3 0.0038
6126 Carbonic anhydrase 7 CA7 0.0038
594 Thyroxine-binding globulin SERPINA7 0.0037
908 Glutathione S-transferase theta-1 GSTT1 0.0037
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0036
1992 Vitamin D-binding protein GC 0.0036
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0036
6151 Monocarboxylate transporter 10 SLC16A10 0.0036
2112 Toll-like receptor 9 TLR9 0.0035
563 Thyroid peroxidase TPO 0.0035
939 50S ribosomal protein L3 rplC 0.0035
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0035
758 Thyroid hormone receptor alpha THRA 0.0034
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0034
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0034
1483 Membrane copper amine oxidase AOC3 0.0034
6599 HTH-type transcriptional regulator ttgR ttgR 0.0034
1714 Mitogen-activated protein kinase 3 MAPK3 0.0034
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0033
6824 Tyrosine-protein kinase Lyn LYN 0.0033
5880 Thrombopoietin receptor MPL 0.0033
164 Histamine H4 receptor HRH4 0.0033
1374 Natriuretic peptides B NPPB 0.0033
6432 Transporter snf 0.0033
4192 DNA topoisomerase 2-beta TOP2B 0.0033
1827 Gap junction alpha-1 protein GJA1 0.0033
1908 Vascular cell adhesion protein 1 VCAM1 0.0033
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0033
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0033
936 Ephrin type-A receptor 2 EPHA2 0.0032
4784 Beta-mannosidase manB 0.0032
6695 Beta-mannosidase BT_0458 0.0032
1039 Histone deacetylase 9 HDAC9 0.0032
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0032
229 Retinoic acid receptor beta RARB 0.0032
2107 Microtubule-associated protein 1A MAP1A 0.0032
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0031
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0031
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0031
1196 Complement decay-accelerating factor CD55 0.0031
730 Retinoic acid receptor alpha RARA 0.0031
3086 Plasmepsin-2 Not Available 0.0031
2021 Thrombomodulin THBD 0.0031
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0031
1227 Cytochrome b MT-CYB 0.0031
6386 Cytochrome b petB 0.0031
6937 Cytochrome b MT-CYB 0.0031
674 Dihydroorotate dehydrogenase homolog, mitochondrial PFF0160c 0.0031
5798 Mitogen-activated protein kinase 11 MAPK11 0.0031
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0031
346 Thyroid hormone receptor beta-1 THRB 0.0031
605 Fumarate reductase flavoprotein subunit frdA 0.003
2709 Fumarate reductase flavoprotein subunit SO_0970 0.003
3673 Fumarate reductase flavoprotein subunit fccA 0.003
4912 Fumarate reductase flavoprotein subunit ifcA 0.003
6549 Fumarate reductase flavoprotein subunit frdA 0.003
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.003
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.003
5923 Microtubule-associated protein tau MAPT 0.003
5924 Microtubule-associated protein 4 MAP4 0.003
2578 Tubulin beta-3 chain TUBB3 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.003
2599 Tyrosine-protein kinase HCK HCK 0.003
3611 Cytidine deaminase cdd 0.003
3707 Cytidine deaminase cdd 0.003
4211 Cytidine deaminase CDA 0.003
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0029
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0029
4773 Deoxycytidine kinase DCK 0.0029
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0029
6500 Phospholipase A2 PLA2G1B 0.0029
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0029
719 Retinoic acid receptor responder protein 1 RARRES1 0.0028
770 Retinoic acid-induced protein 3 GPRC5A 0.0028
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0028
1291 cAMP response element-binding protein CREB1 0.0028
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0028
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0028
2998 Sialic acid-binding Ig-like lectin 7 SIGLEC7 0.0028
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0028
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0028
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0028
1200 AMBP protein AMBP 0.0028
3866 Serum amyloid A protein SAA1 0.0028
1932 Apolipoprotein E APOE 0.0028
6131 Carbonic anhydrase 14 CA14 0.0027
2808 Chloramphenicol acetyltransferase 3 cat3 0.0027
6232 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short GNAS 0.0027
6233 Adenylate cyclase type 2 ADCY2 0.0027
976 Platelet glycoprotein IX GP9 0.0027
6234 Adenylate cyclase type 5 ADCY5 0.0027
199 Monocarboxylate transporter 8 SLC16A2 0.0027
1144 Hepatocyte growth factor receptor MET 0.0027
4210 Toll-like receptor 4 TLR4 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0027
2159 Quinone oxidoreductase CRYZ 0.0027
5934 Cytochrome P450 26A1 CYP26A1 0.0027
4311 tRNA TRDMT1 0.0026
4325 tRNA trmD 0.0026
4328 tRNA trmD 0.0026
751 Potassium channel subfamily K member 6 KCNK6 0.0026
4217 Telomerase reverse transcriptase TERT 0.0026
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0026
992 Protein tyrosine kinase 2 beta PTK2B 0.0026
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0025
3639 Thymidine phosphorylase deoA 0.0025
3936 Thymidine phosphorylase TYMP 0.0025
1385 Angiotensin-converting enzyme 2 ACE2 0.0025
569 Retinal dehydrogenase 2 ALDH1A2 0.0025
267 Plasminogen activator inhibitor 1 SERPINE1 0.0025
4787 Envelope glycoprotein gp160 env 0.0025
4820 Envelope glycoprotein gp160 env 0.0025
5727 Envelope glycoprotein gp160 env 0.0025
2417 Chloramphenicol acetyltransferase cat 0.0025
3278 Chloramphenicol acetyltransferase cat 0.0025
2810 Dr hemagglutinin structural subunit draA 0.0025
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0025
3937 Fatty-acid amide hydrolase FAAH 0.0025
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0025
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0024
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0024
1517 Beta-3 adrenergic receptor ADRB3 0.0024
735 Alanine aminotransferase 1 GPT 0.0024
3904 Alanine aminotransferase 2 GPT2 0.0024
1864 RET proto-oncogene RET 0.0024
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0024
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0024
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0024
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0024
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0024
759 Free fatty acid receptor 1 FFAR1 0.0024
1818 Long-chain-fatty-acid--CoA ligase 3 ACSL3 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
172 Potassium channel subfamily K member 1 KCNK1 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
233 Potassium channel subfamily K member 2 KCNK2 0.0024
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0024
2297 Genome polyprotein Not Available 0.0024
2322 Genome polyprotein Not Available 0.0024
2694 Genome polyprotein Not Available 0.0024
2719 Genome polyprotein Not Available 0.0024
2860 Genome polyprotein Not Available 0.0024
2928 Genome polyprotein Not Available 0.0024
3160 Genome polyprotein Not Available 0.0024
3260 Genome polyprotein Not Available 0.0024
4783 Genome polyprotein Not Available 0.0024
5726 Genome polyprotein Not Available 0.0024
5779 Genome polyprotein Not Available 0.0024
5867 Genome polyprotein Not Available 0.0024
6253 Genome polyprotein Not Available 0.0024
6301 Genome polyprotein Not Available 0.0024
6380 Genome polyprotein Not Available 0.0024
6381 Genome polyprotein Not Available 0.0024
6437 Genome polyprotein Not Available 0.0024
6520 Genome polyprotein Not Available 0.0024
6521 Genome polyprotein Not Available 0.0024
6652 Genome polyprotein Not Available 0.0024
6734 Genome polyprotein Not Available 0.0024
6735 Genome polyprotein Not Available 0.0024
6736 Genome polyprotein Not Available 0.0024
6737 Genome polyprotein Not Available 0.0024
6738 Genome polyprotein Not Available 0.0024
6739 Genome polyprotein Not Available 0.0024
6744 Genome polyprotein Not Available 0.0024
6748 Genome polyprotein Not Available 0.0024
6894 Genome polyprotein Not Available 0.0024
6898 Genome polyprotein Not Available 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
6048 Troponin C, skeletal muscle TNNC2 0.0024
611 Retinal dehydrogenase 1 ALDH1A1 0.0024
1770 Phospholipase C PLCL1 0.0024
2841 Phospholipase C plc 0.0024
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0024
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0024
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0023
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0023
4221 Vascular endothelial growth factor VEGF 0.0023
5816 Cadherin-5 CDH5 0.0023
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0023
2236 Casein kinase II subunit alpha CSNK2A1 0.0023
6221 Steroid hormone receptor ERR1 ESRRA 0.0023
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0023
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0023
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0023
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0022
1650 Heme carrier protein 1 SLC46A1 0.0022
6044 Serum paraoxonase/lactonase 3 PON3 0.0022
291 Nitric-oxide synthase, endothelial NOS3 0.0022
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0022
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0022
3480 Mannan endo-1,4-beta-mannosidase manA 0.0022
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0022
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0022
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0022
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0022
2232 Interleukin-5 IL5 0.0022
298 Renin REN 0.0021
1593 Mucin-2 MUC2 0.0021
6506 Stathmin-4 STMN4 0.0021
1792 Tissue-type plasminogen activator PLAT 0.0021
3437 Eosinophil lysophospholipase CLC 0.0021
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0021
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0021
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0021
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0021
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0021
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0021
1053 BC269730_2 FADS1 0.0021
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0021
1395 Sodium/calcium exchanger 1 SLC8A1 0.0021
3957 Adenosine deaminase ADA 0.0021
572 Integrin alpha-L ITGAL 0.0021
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0021
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0021
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0021
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0021
2320 Thymidine kinase, cytosolic TK1 0.002
6459 Glycodelin PAEP 0.002
896 Glutathione S-transferase Mu 1 GSTM1 0.002
5433 UPF0230 protein TM_1468 TM_1468 0.002
3616 Fatty acid-binding protein, epidermal FABP5 0.002
5431 Lipid binding protein Not Available 0.002
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.002
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.002
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.002
1558 Transient receptor potential cation channel subfamily V member 1 TRPV1 0.002
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.002
2216 Fibroblast growth factor receptor 4 FGFR4 0.002
633 Penicillin-binding proteins 1A/1B pbpA 0.0019
461 Glycine receptor subunit alpha-3 GLRA3 0.0019
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0019
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0019
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0019
6167 Organic solute transporter subunit beta OSTB 0.0019
6166 Organic solute transporter subunit alpha OSTA 0.0019
5998 Toll-like receptor 8 TLR8 0.0018
6218 Pannexin-1 PANX1 0.0018
712 Tubulin alpha chain TUB1 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
565 Extracellular calcium-sensing receptor CASR 0.0018
1123 Eosinophil cationic protein RNASE3 0.0018
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
613 Atrial natriuretic peptide receptor A NPR1 0.0017
6042 Prostaglandin reductase 2 PTGR2 0.0017
268 Adenosine A2b receptor ADORA2B 0.0017
543 Penicillin-binding protein 1B mrcB 0.0017
6186 Penicillin-binding protein 1B ponB 0.0017
6822 Penicillin-binding protein 1b pbp1b 0.0017
6844 Penicillin-binding protein 1b pbp1b 0.0017
283 SEC14-like protein 2 SEC14L2 0.0017
159 Penicillin-binding protein 2B penA 0.0017
6121 Penicillin-binding protein 2B penA 0.0017
144 Hemoglobin subunit alpha HBA1 0.0017
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0017
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0016
6837 Serine/threonine-protein kinase 17B STK17B 0.0016
6766 O-GlcNAcase BT_4395 BT_4395 0.0016
3426 Glutamine synthetase glnA 0.0016
3987 Glutamine synthetase GLUL 0.0016
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0016
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0016
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0016
4226 Uridine phosphorylase 2 UPP2 0.0016
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0016
2211 Fatty acid-binding protein, heart FABP3 0.0016
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0016
3221 Cytochrome c4 cc4 0.0016
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0016
173 Toll-like receptor 7 TLR7 0.0016
76 Nitric-oxide synthase, brain NOS1 0.0016
822 Aldose reductase AKR1B1 0.0016
3913 Glutamic acid decarboxylase GAD65 0.0016
3233 Bile acid receptor NR1H4 0.0015
6163 Copper-transporting ATPase 2 ATP7B 0.0015
6165 Copper-transporting ATPase 1 ATP7A 0.0015
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0015
6755 Poliovirus receptor PVR 0.0015
4785 Ig gamma-1 chain C region IGHG1 0.0015
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0015
702 UMP-CMP kinase CMPK1 0.0015
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0015
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0015
6677 Myelin P2 protein PMP2 0.0015
922 Glutamate receptor 4 GRIA4 0.0015
924 Glutamate receptor, ionotropic kainate 3 GRIK3 0.0015
919 Glutamate receptor, ionotropic kainate 4 GRIK4 0.0015
4024 Mitochondrial glutamate carrier 2 SLC25A18 0.0015
920 Glutamate receptor, ionotropic kainate 5 GRIK5 0.0015
4025 Mitochondrial glutamate carrier 1 SLC25A22 0.0015
4022 Glutamate--ammonia ligase domain-containing protein 1 LGSN 0.0015
4018 Glutamate receptor delta-2 subunit GRID2 0.0015
4027 Glutamate receptor delta-1 subunit GRID1 0.0015
1912 Excitatory amino acid transporter 1 SLC1A3 0.0015
4019 Excitatory amino acid transporter 4 SLC1A6 0.0015
4016 Excitatory amino acid transporter 5 SLC1A7 0.0015
4026 Aspartyl aminopeptidase DNPEP 0.0015
915 Delta 1-pyrroline-5-carboxylate synthetase ALDH18A1 0.0015
4021 Probable glutamyl-tRNA synthetase, mitochondrial EARS2 0.0015
4023 N-acetylglutamate synthase, mitochondrial NAGS 0.0015
1047 Excitatory amino acid transporter 2 SLC1A2 0.0015
664 Glutamate decarboxylase 2 GAD2 0.0015
3890 Glutamate decarboxylase 2 GAD2 0.0015
4017 5-oxoprolinase OPLAH 0.0015
927 Metabotropic glutamate receptor 8 GRM8 0.0015
925 Metabotropic glutamate receptor 4 GRM4 0.0015
926 Metabotropic glutamate receptor 7 GRM7 0.0015
4020 Glutamyl aminopeptidase ENPEP 0.0015
1360 Sphingomyelin phosphodiesterase SMPD1 0.0015
4225 Uridine phosphorylase 1 UPP1 0.0015
4948 Cytochrome c-553 Not Available 0.0015
4923 Cytochrome c3 DvMF_2499 0.0015
4945 Cytochrome c3 Not Available 0.0015
4949 Cytochrome c3 DVU_3171 0.0015
4968 Cytochrome c3 cytc3 0.0015
4997 Cytochrome c3 SO_2727 0.0015
5219 Cytochrome c3 cyd 0.0015
4902 Nine-heme cytochrome c Ddes_2038 0.0015
3189 High-molecular-weight cytochrome c hmcA 0.0015
1525 Heparin-binding growth factor 2 FGF2 0.0015
1569 G1/S-specific cyclin-D1 CCND1 0.0015
1341 Histamine H3 receptor HRH3 0.0014
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0014
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0014
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0014
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0014
760 Fibroblast growth factor 1 FGF1 0.0014
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0014
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0014
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.0014
1760 Aminopeptidase N ANPEP 0.0014
6843 Aminopeptidase N pepN 0.0014
2129 Sucrase-isomaltase, intestinal SI 0.0014
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.0014
413 Amidophosphoribosyltransferase PPAT 0.0014
2515 Amidophosphoribosyltransferase purF 0.0014
3714 Amidophosphoribosyltransferase purF 0.0014
117 Sterol O-acyltransferase 1 SOAT1 0.0014
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0014
1313 Lactoylglutathione lyase GLO1 0.0013
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0013
625 Glutamate carboxypeptidase 2 FOLH1 0.0013
6211 Tubulin epsilon chain TUBE1 0.0013
6212 Tubulin gamma-1 chain TUBG1 0.0013
6210 Tubulin delta chain TUBD1 0.0013
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0013
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0013
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0013
6168 Solute carrier family 22 member 16 SLC22A16 0.0013
801 Kynurenine/alpha-aminoadipate aminotransferase mitochondrial AADAT 0.0013
665 Phosphoserine aminotransferase PSAT1 0.0013
4652 Phosphoserine aminotransferase serC 0.0013
3895 Kynurenine--oxoglutarate transaminase 3 CCBL2 0.0013
420 Glutamate decarboxylase 1 GAD1 0.0013
3900 Glutamate decarboxylase 1 GAD1 0.0013
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0013
3917 Methylenetetrahydrofolate reductase MTHFR 0.0013
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0013
3984 Probable glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial PET112L 0.0013
917 Glutaminase kidney isoform, mitochondrial GLS 0.0013
3991 Glutamine-dependent NAD(+) synthetase NADSYN1 0.0013
5 Glutaminase liver isoform, mitochondrial GLS2 0.0013
355 GMP synthase [glutamine-hydrolyzing] GMPS 0.0013
4353 GMP synthase [glutamine-hydrolyzing] guaA 0.0013
3982 Phosphoribosylformylglycinamidine synthase PFAS 0.0013
5261 Phosphoribosylformylglycinamidine synthase purL 0.0013
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0013
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0013
668 Glutamate--cysteine ligase regulatory subunit GCLM 0.0013
4386 Hemoglobin-like protein HbN glbN 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
3382 Glycolipid transfer protein GLTP 0.0012
2240 Cell division protein kinase 2 CDK2 0.0012
3823 Cytokine receptor common gamma chain IL2RG 0.0012
85 Growth hormone receptor GHR 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
1295 Fatty acid synthase FASN 0.0012
4954 Soluble cytochrome b558 Not Available 0.0012
4925 Cytochrome c-type protein SHP shp 0.0012
4916 Cyanoglobin glbN 0.0012
4947 Bacterial hemoglobin vhb 0.0012
4915 Cytochrome c-550 psbV 0.0012
4959 Cytochrome c-550 psbV 0.0012
5216 Cytochrome c-550 psbV 0.0012
4943 Cytochrome c6 petJ 0.0012
4934 Cytochrome c-551 nirM 0.0012
5218 Cytochrome c-551 nirM 0.0012
4905 Cytochrome c2 Not Available 0.0012
4939 Cytochrome c2 cycA 0.0012
4964 Cytochrome c2 cycA 0.0012
4979 Cytochrome c2 cycA 0.0012
6673 Cytochrome c2 cycA 0.0012
4994 Hemoglobin-like protein HbO glbO 0.0012
4975 Cytochrome c-556 RPA3973 0.0012
4984 Neuroglobin NGB 0.0012
186 Glutamate--cysteine ligase catalytic subunit GCLC 0.0012
4936 Cytochrome c2 iso-2 Not Available 0.0012
4998 Hemoglobin-like protein yjbI yjbI 0.0012
4981 Iron-starvation protein PigA pigA 0.0012
4942 Diheme cytochrome c napB napB 0.0012
4909 CooA protein cooA 0.0012
5000 HemO hemO 0.0012
4907 Cytochrome c-L moxG 0.0012
6865 Cytochrome c-L moxG 0.0012
4961 Hemophore HasA hasA 0.0012
4910 Cytoglobin CYGB 0.0012
644 Heme oxygenase 2 HMOX2 0.0012
4982 Heme oxygenase 2 pbsA2 0.0012
3877 Growth-inhibiting protein 18 GIG18 0.0012
4976 Apocytochrome f petA 0.0012
6407 Apocytochrome f petA 0.0012
4971 Nonaheme cytochrome c hmcA 0.0012
4904 Cytochrome c family protein GSU1996 0.0012
4935 Cytochrome c-554 cycA1 0.0012
4937 Cytochrome oxidase subunit II rcoxA 0.0012
4989 Cytochrome c551 peroxidase ccp 0.0012
5222 Cytochrome c551 peroxidase ccpA 0.0012
4764 Cytochrome P450 165C4 CYP165C4 0.0012
4926 Heme-based aerotactic transducer hemAT hemAT 0.0012
4999 Cytochrome P450 165B3 CYP165B3 0.0012
4960 Putative cytochrome P450-family protein SCO7417 0.0012
4931 Cytochrome P450 167A1 CYP167A1 0.0012
4972 P450cin cinA 0.0012
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0012
4903 Methyl-accepting chemotaxis protein Tar4 0.0012
4993 Hydroxylamine oxidoreductase hao1 0.0012
4922 Cytochrome c, putative SO_4144 0.0012
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0012
4952 Catalase/peroxidase katA 0.0012
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0012
3093 Catalase HPII katE 0.0012
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0012
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0012
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0012
763 Tyrosine aminotransferase TAT 0.0012
5493 Tyrosine aminotransferase Not Available 0.0012
1671 Excitatory amino acid transporter 3 SLC1A1 0.0012
914 Formimidoyltransferase-cyclodeaminase FTCD 0.0011
707 72 kDa type IV collagenase MMP2 0.0011
484 Tyrosine-protein kinase ABL2 ABL2 0.0011
426 Aspartate aminotransferase, mitochondrial GOT2 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
2298 Cytochrome P450-cam camC 0.0011
83 Alpha-aminoadipic semialdehyde synthase, mitochondrial AASS 0.0011
2300 Lysozyme E 0.0011
3633 Lysozyme R 0.0011
5597 Lysozyme 17 0.0011
210 Bifunctional aminoacyl-tRNA synthetase [Includes: Glutamyl-tRNA synthetase EPRS 0.0011
724 Interleukin-2 receptor alpha chain IL2RA 0.0011
717 Interleukin-2 receptor subunit beta IL2RB 0.0011
586 Aspartate aminotransferase, cytoplasmic GOT1 0.0011
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.001
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
4228 Keratin, type II cytoskeletal 7 KRT7 0.001
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.001
1063 Signal transducer and activator of transcription 5B STAT5B 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
795 Branched-chain-amino-acid aminotransferase, mitochondrial BCAT2 0.001
574 Branched-chain-amino-acid aminotransferase, cytosolic BCAT1 0.001
512 DNA-directed RNA polymerase alpha chain rpoA 0.001
5772 DNA-directed RNA polymerase alpha chain rpoA 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
1176 Mitogen-activated protein kinase 1 MAPK1 0.001
2473 Tyrosine-protein kinase CSK CSK 0.001
2398 Tyrosine-protein kinase ZAP-70 ZAP70 0.001
65 Matrix metalloproteinase-9 Not Available 0.001
2268 Cholesterol oxidase choB 0.0009
2822 Cholesterol oxidase choA 0.0009
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0009
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0009
828 Phenylalanine-4-hydroxylase PAH 0.0009
3109 Phenylalanine-4-hydroxylase phhA 0.0009
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0009
1048 Protein S100-A13 S100A13 0.0009
2226 Protein S100-A12 S100A12 0.0009
2283 Steroid Delta-isomerase ksi 0.0009
2920 Steroid Delta-isomerase ksi 0.0009
4920 Peroxidase/catalase katG 0.0009
2119 Cytochrome b5 CYB5A 0.0009
390 Adenosine A3 receptor ADORA3 0.0009
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0009
6171 Solute carrier family 28 member 3 SLC28A3 0.0009
4990 PpcA ppcA 0.0009
3375 Acidic cytochrome c3 Not Available 0.0009
4988 Sulfite oxidase, mitochondrial SUOX 0.0009
2915 Sensor protein fixL fixL 0.0009
4944 Sensor protein fixL fixL 0.0009
4037 Hypothetical protein GPX1 0.0009
4297 Hypothetical protein SP_1951 0.0009
4521 Hypothetical protein BC_2969 0.0009
4540 Hypothetical protein TM_1070 0.0009
4555 Hypothetical protein MT1739 0.0009
4569 Hypothetical protein mshD 0.0009
4578 Hypothetical protein PA3270 0.0009
4747 Hypothetical protein PA3967 0.0009
5177 Hypothetical protein TM_0096 0.0009
5194 Hypothetical protein PA1204 0.0009
5240 Hypothetical protein Rv2991 0.0009
5370 Hypothetical protein TM_1158 0.0009
5710 Hypothetical protein Tb927.5.1360 0.0009
3570 Cytochrome P450 152A1 cypC 0.0009
4385 Cytochrome c' Not Available 0.0009
4967 Cytochrome c' cycA 0.0009
5038 Cytochrome c' Not Available 0.0009
5223 Cytochrome c' cycP 0.0009
2132 Protein S100-B S100B 0.0009
4289 Cytochrome P450 TT_P0059 0.0009
6262 Cytochrome P450 staP 0.0009
4992 Cytochrome c peroxidase Not Available 0.0009
4813 Heme oxygenase hmuO 0.0009
5769 Heme oxygenase Not Available 0.0009
3404 Exotoxin A eta 0.0008
1184 Interferon beta IFNB1 0.0008
2230 Catalase CAT 0.0008
3249 Catalase katA 0.0008
3625 Catalase katA 0.0008
4539 Catalase katA 0.0008
4941 Catalase katB 0.0008
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
6122 Carbonic anhydrase 3 CA3 0.0008
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0008
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0008
1867 Major prion protein PRNP 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
2530 Protein kinase C theta type PRKCQ 0.0008
1025 Aquaporin-1 AQP1 0.0008
3411 Cytochrome P450 121 cyp121 0.0008
3670 Soluble cytochrome b562 precursor cybC 0.0008
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0008
3830 Calreticulin CALR 0.0008
2091 Endoplasmin HSP90B1 0.0008
3291 Cytochrome c-552 cycA 0.0007
4927 Cytochrome c-552 nrfA 0.0007
4938 Cytochrome c-552 cycA 0.0007
4953 Cytochrome c-552 nrfA 0.0007
5217 Cytochrome c-552 cycM 0.0007
2617 Nitric oxide synthase oxygenase nos 0.0007
2701 Nitric oxide synthase oxygenase nos 0.0007
3102 Flavohemoprotein hmp 0.0007
4969 Flavohemoprotein hmp 0.0007
473 L-lactate dehydrogenase A chain LDHA 0.0007
6034 Hydroxyindole O-methyltransferase ASMT 0.0007
6035 Nuclear receptor ROR-beta RORB 0.0007
6036 Eosinophil peroxidase EPX 0.0007
6207 30S ribosomal protein S14 rpsN 0.0007
4692 A/G-specific adenine glycosylase mutY 0.0007
6209 30S ribosomal protein S19 rpsS 0.0007
6712 30S ribosomal protein S19 rpsS 0.0007
6726 30S ribosomal protein S19 rpsS 0.0007
645 Penicillin-binding protein 1A mrcA 0.0007
5805 Penicillin-binding protein 1A ponA 0.0007
6185 Penicillin-binding protein 1A mrcA 0.0007
6799 Penicillin-binding protein 1A pbpA 0.0007
2408 Tyrosine-protein kinase SYK SYK 0.0007
3587 Gastrotropin FABP6 0.0007
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0007
2290 ADP-ribosyl cyclase 2 BST1 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
1830 5'-nucleotidase NT5E 0.0007
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0007
4666 Fucose-binding lectin PA-IIL lecB 0.0007
2972 6-deoxyerythronolide B hydroxylase eryF 0.0007
2372 Bifunctional tail protein 9 0.0007
125 DNA polymerase beta POLB 0.0007
4878 Glycoprotein hormones alpha chain CGA 0.0006
1052 Cytotoxic T-lymphocyte protein 4 CTLA4 0.0006
1072 Granzyme B GZMB 0.0006
4871 Endo-beta-N-acetylglucosaminidase F3 endOF3 0.0006
4880 Membrane cofactor protein CD46 0.0006
4889 Ig epsilon chain C region IGHE 0.0006
4877 Beta-mannanase man 0.0006
1563 Platelet glycoprotein Ib alpha chain GP1BA 0.0006
4850 Beta-2-glycoprotein 1 APOH 0.0006
4856 CD209 antigen CD209 0.0006
4189 Alpha-galactosidase A GLA 0.0006
4869 Major capsid protein A430L 0.0006
757 Fusion glycoprotein F0 F 0.0006
4875 Fusion glycoprotein F0 F 0.0006
4852 Reticulon-4 receptor RTN4R 0.0006
4845 ADAM 33 ADAM33 0.0006
1354 Beta-glucuronidase GUSB 0.0006
442 Envelope glycoprotein gp41 0.0006
4859 Envelope glycoprotein env 0.0006
4882 Dipeptidyl aminopeptidase-like protein 6 DPP6 0.0006
4721 Beta-1,4-mannanase manA 0.0006
3352 Structural polyprotein Not Available 0.0006
3628 Structural polyprotein Not Available 0.0006
4892 Structural polyprotein Not Available 0.0006
4608 Putative cytochrome P450 SCO1207 0.0006
4963 Putative cytochrome P450 SCO2884 0.0006
6254 Putative cytochrome P450 SCO6998 0.0006
6228 Nuclear receptor coactivator 1 NCOA1 0.0006
2802 Endoglucanase G celCCG 0.0006
6241 Nuclear receptor coactivator 2 NCOA2 0.0006
342 P protein [Includes: DNA-directed DNA polymerase P 0.0006
612 P protein [Includes: DNA-directed DNA polymerase P 0.0006
765 Indoleamine 2,3-dioxygenase IDO1 0.0006
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0006
358 Cystathionine beta-synthase CBS 0.0006
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0006
693 Hemoglobin subunit beta HBB 0.0006
4193 Atrial natriuretic peptide clearance receptor NPR3 0.0006
793 T-cell surface antigen CD2 CD2 0.0006
4861 Interleukin-6 receptor alpha chain IL6R 0.0006
119 Carcinoembryonic antigen-related cell adhesion molecule 1 CEACAM1 0.0006
3837 Cytokine receptor common beta chain CSF2RB 0.0006
5221 Cytochrome c3, 13 kDa Not Available 0.0006
3152 Cytochrome c'' cycA 0.0006
5220 Split-Soret cytochrome c Ddes_2150 0.0006
3700 Cytochrome c-552 precursor nrfA 0.0006
5626 Nucleoside diphosphate kinase B NME2 0.0005
1721 Glycogen synthase kinase-3 beta GSK3B 0.0005
2430 Chondroitinase B cslB 0.0005
6268 Hydroxyacid oxidase 1 HAO1 0.0005
3238 Multidrug resistance protein mexA mexA 0.0005
3116 Bacterioferritin bfr 0.0005
4906 Bacterioferritin bfr 0.0005
4965 Bacterioferritin bfr 0.0005
3173 Enolase eno 0.0005
3709 Glycerol uptake facilitator protein glpF 0.0005
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0005
3393 TGF-beta receptor type-2 TGFBR2 0.0005
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0005
810 Heme oxygenase 1 HMOX1 0.0005
3391 Heme oxygenase 1 pbsA1 0.0005
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0005
1379 Interleukin-12 subunit beta IL12B 0.0005
4890 Hemagglutinin HA 0.0005
6566 Hemagglutinin Not Available 0.0005
3127 Nitrite reductase nirS 0.0005
3284 Nitrite reductase nirS 0.0005
4857 Zinc-alpha-2-glycoprotein AZGP1 0.0005
6858 Inactive carboxylesterase 4 CES1P1 0.0005
2852 DNA mismatch repair protein mutL mutL 0.0005
6120 Cation-independent mannose-6-phosphate receptor IGF2R 0.0005
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0005
3191 Histidinol dehydrogenase hisD 0.0005
5294 Nucleoside diphosphate kinase A NME1 0.0005
18 High affinity immunoglobulin epsilon receptor subunit alpha FCER1A 0.0005
554 Low-density lipoprotein receptor LDLR 0.0004
852 Heparin cofactor 2 SERPIND1 0.0004
3405 Quinohaemoprotein ethanol dehydrogenase type-1 qheDH 0.0004
1859 Prostatic acid phosphatase ACPP 0.0004
595 Fibrinogen alpha chain FGA 0.0004
3140 Hemagglutinin-neuraminidase HN 0.0004
3609 Hemagglutinin-neuraminidase HN 0.0004
3444 Cyanovirin-N Not Available 0.0004
3258 Mannosyl-oligosaccharide alpha-1,2-mannosidase MSDC 0.0004
5818 Folate receptor alpha FOLR1 0.0004
4509 Acetoin(diacetyl) reductase budC 0.0004
340 Apoptotic protease-activating factor 1 APAF1 0.0004
958 Insulin-like growth factor 1 receptor IGF1R 0.0004
2391 Ferrochelatase hemH 0.0004
6502 Ferrochelatase DKFZp686P18130 0.0004
1591 Ferrochelatase, mitochondrial FECH 0.0004
6316 ADP-ribosylation factor 1 ARF1 0.0004
3689 Endoglucanase A celA 0.0004
3814 Complement C1r subcomponent C1R 0.0004
3009 Beta-glucanase Not Available 0.0004
5411 Slt-IIvB stxB2e 0.0004
5565 Inorganic polyphosphate/ATP-glucomannokinase ppgmk 0.0004
5563 Galectin-2 LGALS2 0.0004
1875 Pulmonary surfactant-associated protein D SFTPD 0.0004
5569 Endo-1,4-beta glucanase EngF engF 0.0004
5046 Ecotin eco 0.0004
3793 Aspartate ammonia-lyase aspA 0.0004
5554 D-galactose-binding periplasmic protein mglB 0.0004
3741 D-galactose-binding periplasmic protein precursor mglB 0.0004
5568 Endoglucanase C307 celC307 0.0004
5553 Endoglucanase E1 Acel_0614 0.0004
5562 Hexokinase Not Available 0.0004
3744 Endoglucanase SS precursor celS 0.0004
5570 Endoglucanase E-4 celD 0.0004
5559 Neopullulanase nplT 0.0004
4670 Cellulase B celB 0.0004
4668 Laminarinase TM_0024 0.0004
4667 BH0236 protein BH0236 0.0004
4671 Endoglucanase C cenC 0.0004
64 Neuraminidase NA 0.0004
641 Neuraminidase NA 0.0004
2676 Neuraminidase NA 0.0004
3026 Neuraminidase NA 0.0004
3519 Neuraminidase NA 0.0004
6007 Neuraminidase NA 0.0004
2577 Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase MAN1B1 0.0004
1243 Cathepsin D CTSD 0.0003
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0003
1439 Lactotransferrin LTF 0.0003
293 Gamma-glutamyl hydrolase GGH 0.0003
825 Arsenical pump-driving ATPase ASNA1 0.0003
3435 Arsenical pump-driving ATPase arsA 0.0003
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0003
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0003
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0003
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0003
733 Activin receptor type 1B ACVR1B 0.0003
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0003
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0003
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0003
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0003
154 AFG3-like protein 2 AFG3L2 0.0003
395 ALK tyrosine kinase receptor Not Available 0.0003
309 Antithrombin-III SERPINC1 0.0003
1782 Neutrophil gelatinase-associated lipocalin LCN2 0.0003
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0003
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0003
6493 Cytochrome c oxidase subunit 6C COX6C 0.0003
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0003
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0003
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0003
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0003
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0003
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0003
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0003
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0003
6559 Cytochrome c oxidase subunit 2 ctaC 0.0003
6669 Cytochrome c oxidase subunit 2 ctaC 0.0003
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0003
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0003
6558 Cytochrome c oxidase subunit 1 ctaD 0.0003
5176 YtnJ moxC 0.0003
5416 Coat protein VP1 Not Available 0.0003
2705 Dimethyl sulfoxide reductase dmsA 0.0003
5247 Endo-1,4-beta-xylanase Not Available 0.0003
5248 Endo-1,4-beta-xylanase xlnA 0.0003
5250 Endo-1,4-beta-xylanase xyl 0.0003
4669 Endo-1,4-beta-xylanase A xynA 0.0003
4715 Endo-1,4-beta-xylanase A xlnA 0.0003
5560 Endo-1,4-beta-xylanase A xynA 0.0003
1503 Galectin-7 LGALS7 0.0003
5498 Maltoporin lamB 0.0003
5561 Maltoporin lamB 0.0003
5056 Maltooligosyltrehalose trehalohydrolase, putative treZ 0.0003
3525 ADP-ribose pyrophosphatase, mitochondrial NUDT9 0.0003
4622 Amylase Not Available 0.0003
2728 Glucan 1,4-alpha-maltotetraohydrolase amyP 0.0003
292 Activin receptor type-1 ACVR1 0.0003
849 Activated CDC42 kinase 1 TNK2 0.0003
6307 Ig gamma-2 chain C region IGHG2 0.0003
2826 Glucose--fructose oxidoreductase gfo 0.0003
1881 Hexokinase-1 HK1 0.0003
2581 Chondroitinase AC cslA 0.0003
2540 Choloylglycine hydrolase cbh 0.0003
6847 Lactase-phlorizin hydrolase LCT 0.0003
2324 Botulinum neurotoxin type B botB 0.0003
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0003
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0003
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0003
297 Adenylate cyclase type 1 ADCY1 0.0003
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0003
3153 Quinoprotein glucose dehydrogenase-B gdhB 0.0003
3747 Cellulase B precursor celB 0.0003
3547 Enterotoxin type B entB 0.0003
2856 Glucosamine-6-phosphate isomerase GNPDA1 0.0003
2564 Glucan 1,4-alpha-maltohexaosidase Not Available 0.0003
4819 Hydrolase Not Available 0.0003
5249 Hydrolase Not Available 0.0003
5436 Hydrolase Not Available 0.0003
2531 Alpha-amylase amyE 0.0003
2948 Alpha-amylase amy 0.0003
3169 Alpha-amylase Not Available 0.0003
2541 Neopullulanase 1 tvaI 0.0003
4811 Amylosucrase ams 0.0003
3091 Maltodextrin phosphorylase malP 0.0003
2606 Neopullulanase 2 tvaII 0.0003
6501 Fatty acid-binding protein, liver FABP1 0.0003
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0003
3225 Shiga toxin B-chain stxB 0.0003
3365 Beta-amylase spoII 0.0003
4830 Aldose 1-epimerase galM 0.0003
6614 Lactase-like protein LCTL 0.0003
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0003
1675 Glucokinase GCK 0.0003
4662 Glucokinase glk 0.0003
3030 Salivary alpha-amylase AMY1A 0.0003
2293 Cyclomaltodextrin glucanotransferase Not Available 0.0003
2508 Cyclomaltodextrin glucanotransferase cgt 0.0003
2523 Cyclomaltodextrin glucanotransferase cgt 0.0003
3207 Cyclomaltodextrin glucanotransferase amyA 0.0003
4272 POSSIBLE CELLULASE CELA1 celA1 0.0003
2570 Tetanus toxin tetX 0.0002
2448 Exoglucanase/xylanase [Includes: Exoglucanase cex 0.0002
3668 Maltose-binding periplasmic protein precursor malE 0.0002
740 Argininosuccinate synthase ASS1 0.0002
865 Argininosuccinate synthase ASS1 0.0002
2680 Argininosuccinate synthase argG 0.0002
3194 Argininosuccinate synthase argG 0.0002
661 ADP/ATP translocase 1 SLC25A4 0.0002
6021 Adenosine kinase ADK 0.0002
2440 Endoglucanase F celCCF 0.0002
2245 Xylose isomerase xylA 0.0002
2253 Xylose isomerase xylA 0.0002
2260 Xylose isomerase xylA 0.0002
2431 Xylose isomerase xylA 0.0002
2252 Endoglucanase 5A cel5A 0.0002
6135 Sodium channel subunit beta-4 SCN4B 0.0002
6134 Sodium channel subunit beta-3 SCN3B 0.0002
6132 Sodium channel subunit beta-1 SCN1B 0.0002
6127 Carbonic anhydrase-related protein CA8 0.0002
6128 Carbonic anhydrase-related protein 10 CA10 0.0002
6133 Sodium channel subunit beta-2 SCN2B 0.0002
6129 Carbonic anhydrase-related protein 11 CA11 0.0002
10 Glycogen phosphorylase, liver form PYGL 0.0002
2723 Cholera enterotoxin subunit B ctxB 0.0002
4513 Pancreatic alpha-amylase AMY2A 0.0002
2427 Ferrichrome-iron receptor fhuA 0.0002
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0002
6130 Carbonic anhydrase 13 CA13 0.0002
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0002
1152 Glycogen phosphorylase, muscle form PYGM 0.0002
3007 Carbonic anhydrase 12 CA12 0.0002
4205 Carbonic anhydrase 9 CA9 0.0002
↑