DT-Web

DB03408 - Gamma-Glutamylcysteine


Identification
Name Gamma-Glutamylcysteine
Accession Number DB03408 (EXPT00168)
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 250.272
Groups experimental
Monoisotopic Weight 250.062342258
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Glutathione synthetase
Name Glutathione synthetase
Gene Name GSS
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.3323

Predictions


Id Partner name Gene Name Score
5269 Glutathione synthetase gshB 0.3323
171 Cysteine dioxygenase CDO-1 0.022
1314 Thiamine transporter 2 SLC19A3 0.0219
4064 Probable cysteinyl-tRNA synthetase, mitochondrial CARS2 0.0219
774 Cysteinyl-tRNA synthetase, cytoplasmic CARS 0.0219
1999 Methylated-DNA--protein-cysteine methyltransferase MGMT 0.0186
668 Glutamate--cysteine ligase regulatory subunit GCLM 0.0184
626 Cysteine dioxygenase type 1 CDO1 0.0178
89 Cysteine sulfinic acid decarboxylase CSAD 0.0174
169 Cysteine desulfurase, mitochondrial NFS1 0.0165
186 Glutamate--cysteine ligase catalytic subunit GCLC 0.0161
358 Cystathionine beta-synthase CBS 0.0157
868 Cystathionine gamma-lyase CTH 0.0156
6151 Monocarboxylate transporter 10 SLC16A10 0.015
586 Aspartate aminotransferase, cytoplasmic GOT1 0.015
5646 Galactokinase GALK1 0.0099
5265 FtsH ftsH 0.0099
3390 Aminoglycoside 3'-phosphotransferase aphA 0.0099
6029 Aminoglycoside 3'-phosphotransferase aphA1 0.0099
5302 TrwB trwB 0.0099
4058 Glycine N-acyltransferase-like protein 2 GLYATL2 0.0093
4057 Glycine N-acyltransferase GLYAT 0.0093
4061 Peroxisomal sarcosine oxidase PIPOX 0.0093
4055 Bile acid CoA:amino acid N-acyltransferase BAAT 0.0093
4056 N-arachidonyl glycine receptor GPR18 0.0093
4060 Vesicular inhibitory amino acid transporter SLC32A1 0.0093
4059 Glycine N-acyltransferase-like protein 1 GLYATL1 0.0093
1088 5-aminolevulinate synthase, erythroid-specific, mitochondrial ALAS2 0.0093
1236 Sodium- and chloride-dependent glycine transporter 1 SLC6A9 0.0093
1466 Glycyl-tRNA synthetase GARS 0.0093
4062 Sodium- and chloride-dependent glycine transporter 2 SLC6A5 0.0093
5312 Kinesin-like protein KIF1A KIF1A 0.0088
2892 Acetylglutamate kinase argB 0.0083
3550 Acetylglutamate kinase argB 0.0083
2371 Pantothenate kinase coaA 0.0082
2950 Inositol-trisphosphate 3-kinase A ITPKA 0.0081
825 Arsenical pump-driving ATPase ASNA1 0.0081
3435 Arsenical pump-driving ATPase arsA 0.0081
2615 Chemotaxis protein cheA cheA 0.0081
1881 Hexokinase-1 HK1 0.0081
6832 Serine/threonine-protein kinase SRPK2 SRPK2 0.0079
2727 S-adenosylmethionine synthetase metK 0.0077
4054 Glycine cleavage system H protein, mitochondrial GCSH 0.0077
575 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial GCAT 0.0074
455 5-aminolevulinate synthase, nonspecific, mitochondrial ALAS1 0.0074
681 Glycine dehydrogenase [decarboxylating], mitochondrial GLDC 0.0074
62 Glycine receptor subunit beta GLRB 0.0074
2817 Phosphoribosylglycinamide formyltransferase 2 purT 0.0074
4034 Glutaredoxin-1 GLRX 0.0072
4037 Hypothetical protein GPX1 0.0072
4297 Hypothetical protein SP_1951 0.0072
4521 Hypothetical protein BC_2969 0.0072
4540 Hypothetical protein TM_1070 0.0072
4555 Hypothetical protein MT1739 0.0072
4569 Hypothetical protein mshD 0.0072
4578 Hypothetical protein PA3270 0.0072
4747 Hypothetical protein PA3967 0.0072
5177 Hypothetical protein TM_0096 0.0072
5194 Hypothetical protein PA1204 0.0072
5240 Hypothetical protein Rv2991 0.0072
5370 Hypothetical protein TM_1158 0.0072
5710 Hypothetical protein Tb927.5.1360 0.0072
4038 Glutathione peroxidase 4 GPX4 0.0072
1975 Phospholipid hydroperoxide glutathione peroxidase, mitochondrial GPX4 0.0072
4035 Glutathione S-transferase Mu 5 GSTM5 0.0072
1928 Leukotriene C4 synthase LTC4S 0.0072
4029 Microsomal glutathione S-transferase 3 MGST3 0.0072
4032 Microsomal glutathione S-transferase 1 MGST1 0.0072
906 Glutathione peroxidase 1 GPX1 0.0072
4043 Glutaredoxin-2, mitochondrial GLRX2 0.0072
4030 Thioredoxin domain-containing protein 12 TXNDC12 0.0072
4033 S-formylglutathione hydrolase ESD 0.0072
4039 CDNA FLJ23636 fis, clone CAS07176 GPX8 0.0072
4036 Glutathione peroxidase 6 GPX6 0.0072
900 Glutathione S-transferase A4 GSTA4 0.0072
903 Glutathione S-transferase A5 GSTA5 0.0072
911 Glutathione peroxidase 3 GPX3 0.0072
4040 Glutathione peroxidase 7 GPX7 0.0072
907 Glutathione peroxidase 2 GPX2 0.0072
910 Epididymal secretory glutathione peroxidase GPX5 0.0072
4042 Glutathione transferase omega-2 GSTO2 0.0072
1056 Gamma-glutamyltranspeptidase 1 GGT1 0.0072
411 Glycine N-methyltransferase GNMT 0.007
5641 Rod shape-determining protein MreB TM_0588 0.007
4178 DNA repair protein RAD51 homolog 1 RAD51 0.007
5649 Potassium-transporting ATPase B chain kdpB 0.007
3794 Osmolarity sensor protein envZ envZ 0.007
5644 Sensor protein phoQ phoQ 0.007
5643 General secretion pathway protein E epsE 0.007
5645 DNA topoisomerase 4 subunit B parE 0.007
6227 DNA topoisomerase 4 subunit B parE 0.007
5642 Chaperone clpB clpB 0.007
383 Glycine amidinotransferase, mitochondrial GATM 0.0069
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0068
3884 SHMT2 protein SHMT2 0.0067
3901 SHMT2 protein SHMT2 0.0067
3885 Hypothetical protein DKFZp686P09201 DKFZp686P09201 0.0067
3879 Serine hydroxymethyltransferase 2 Not Available 0.0067
321 Serine hydroxymethyltransferase, mitochondrial SHMT2 0.0067
897 Glutathione S-transferase kappa 1 GSTK1 0.0066
2251 Thymidylate kinase tmk 0.0066
2254 Thymidylate kinase DTYMK 0.0066
3522 Thymidylate kinase tmk 0.0066
114 Alanine--glyoxylate aminotransferase 2, mitochondrial AGXT2 0.0065
898 Glutathione S-transferase A3 GSTA3 0.0065
3319 Hydroxyacylglutathione hydrolase HAGH 0.0065
4751 Mitogen-activated protein kinase 12 MAPK12 0.0064
909 Maleylacetoacetate isomerase GSTZ1 0.0063
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0063
593 Proton-coupled amino acid transporter 1 SLC36A1 0.0063
349 Serine--pyruvate aminotransferase AGXT 0.0063
740 Argininosuccinate synthase ASS1 0.0063
865 Argininosuccinate synthase ASS1 0.0063
2680 Argininosuccinate synthase argG 0.0063
3194 Argininosuccinate synthase argG 0.0063
2852 DNA mismatch repair protein mutL mutL 0.0062
461 Glycine receptor subunit alpha-3 GLRA3 0.0061
2397 Dihydroxyacetone kinase dhaK 0.0061
2867 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase ispE 0.0061
820 Glycine receptor subunit alpha-2 GLRA2 0.0061
6433 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 PFKFB4 0.0061
3822 Actin, alpha skeletal muscle ACTA1 0.0061
367 Serine hydroxymethyltransferase, cytosolic SHMT1 0.006
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0059
4373 Medium-chain-fatty-acid--CoA ligase Not Available 0.0058
2165 Glutathione S-transferase Mu 2 GSTM2 0.0058
4041 Microsomal glutathione S-transferase 2 MGST2 0.0058
899 Glutathione S-transferase Mu 3 GSTM3 0.0058
905 Glutathione transferase omega-1 GSTO1 0.0057
2299 UDP-N-acetylmuramate--L-alanine ligase murC 0.0057
3231 Death-associated protein kinase 1 DAPK1 0.0056
1721 Glycogen synthase kinase-3 beta GSK3B 0.0056
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0054
901 Glutathione S-transferase Mu 4 GSTM4 0.0054
887 DNA gyrase subunit B gyrB 0.0054
4150 DNA gyrase subunit B gyrB 0.0054
6225 DNA gyrase subunit B gyrB 0.0054
936 Ephrin type-A receptor 2 EPHA2 0.0053
958 Insulin-like growth factor 1 receptor IGF1R 0.0053
482 Glycine receptor subunit alpha-1 GLRA1 0.0052
1313 Lactoylglutathione lyase GLO1 0.0049
4031 Glutathione S-transferase A1 GSTA1 0.0047
4192 DNA topoisomerase 2-beta TOP2B 0.0046
908 Glutathione S-transferase theta-1 GSTT1 0.0045
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0045
714 Glutathione reductase, mitochondrial GSR 0.0043
3932 Glutathione S-transferase A2 GSTA2 0.0042
896 Glutathione S-transferase Mu 1 GSTM1 0.0042
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0042
1836 Mitogen-activated protein kinase 10 MAPK10 0.004
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0038
5314 UPF0079 ATP-binding protein HI0065 HI_0065 0.0038
904 Glutathione S-transferase P GSTP1 0.0038
5293 Shikimate kinase 2 aroL 0.0038
5288 Shikimate kinase aroK 0.0038
5304 UPF0166 protein TM_0021 TM_0021 0.0038
5287 Signaling protein Not Available 0.0038
5292 Putative partitioning protein TT_C1605 0.0038
5266 Activator of hgdC 0.0038
5259 Transcriptional regulator ntrC1 0.0038
6699 Transcriptional regulator Cgl2612 0.0038
5270 ATP-dependent Clp protease ATP-binding subunit clpX clpX 0.0038
3199 Phosphopantetheine adenylyltransferase coaD 0.0038
3543 Phosphopantetheine adenylyltransferase coaD 0.0038
3567 Phosphopantetheine adenylyltransferase coaD 0.0038
5289 Phosphopantetheine adenylyltransferase coaD 0.0038
2874 Nitrogenase iron protein 1 nifH1 0.0038
4346 Polynucleotide kinase pseT 0.0038
5283 D-alanine--D-alanine ligase B ddlB 0.0038
5281 Plasmid segregation protein parM parM 0.0038
5305 Phosphoribosylaminoimidazole carboxylase ATPase subunit purK 0.0038
5275 Multidrug resistance ABC transporter ATP-binding and permease protein lmrA 0.0038
5315 Chaperone protein htpG htpG 0.0038
5290 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0038
5638 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0038
5291 Glycogen synthase 1 glgA1 0.0038
3777 ATP-dependent Clp protease ATP-binding subunit clpA clpA 0.0038
5264 DNA replication protein REP 0.0038
4794 Phosphoenolpyruvate carboxykinase [ATP] pckA 0.0038
5308 Preprotein translocase secA 1 subunit secA1 0.0038
5285 Kinesin heavy chain KIF5B 0.0038
1549 Heat shock 70 kDa protein 1 HSPA1A 0.0038
5299 D-alanine--D-alanine ligase ddl 0.0038
6598 D-alanine--D-alanine ligase ddl 0.0038
5284 Large T antigen Not Available 0.0038
5276 Chromosomal replication initiator protein dnaA dnaA 0.0038
3982 Phosphoribosylformylglycinamidine synthase PFAS 0.0038
5261 Phosphoribosylformylglycinamidine synthase purL 0.0038
5277 Preprotein translocase subunit secA secA 0.0038
2236 Casein kinase II subunit alpha CSNK2A1 0.0037
6136 Multidrug resistance-associated protein 5 ABCC5 0.0036
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0032
3426 Glutamine synthetase glnA 0.0031
3987 Glutamine synthetase GLUL 0.0031
3175 Glutamate--cysteine ligase gshA 0.0031
5295 2-keto-3-deoxy-gluconate kinase TT_P0036 0.003
3470 Hypothetical protein MG245 homolog MPN_348 0.003
2164 Multidrug resistance-associated protein 4 ABCC4 0.003
2751 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.003
4755 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.003
5189 Trimethylamine dehydrogenase tmd 0.003
4106 Guanylate kinase GUK1 0.003
4516 Guanylate kinase gmk 0.003
2270 Dephospho-CoA kinase coaE 0.003
2284 Adenylate kinase adk 0.003
2296 Adenylate kinase adk 0.003
2311 Adenylate kinase adk 0.003
2312 Adenylate kinase Not Available 0.003
6277 Heat shock cognate 71 kDa protein HSPA8 0.003
413 Amidophosphoribosyltransferase PPAT 0.003
2515 Amidophosphoribosyltransferase purF 0.003
3714 Amidophosphoribosyltransferase purF 0.003
4837 Cag-alfa cag-alfa 0.003
4839 DNA polymerase III subunit tau dnaX 0.003
4774 NTPase P4 Not Available 0.003
4838 PMS1 protein homolog 2 PMS2 0.003
2683 Mono-ADP-ribosyltransferase C3 C3 0.0029
340 Apoptotic protease-activating factor 1 APAF1 0.0028
862 Multidrug resistance-associated protein 1 ABCC1 0.0028
5300 Antigen peptide transporter 1 TAP1 0.0028
5271 Focal adhesion kinase 1 PTK2 0.0027
2390 Nonsecretory ribonuclease RNASE2 0.0027
2922 Glycerol kinase glpK 0.0027
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0026
2282 Protein recA recA 0.0026
2315 Protein recA recA 0.0026
2332 Protein recA recA 0.0026
5263 Protein recA recA 0.0026
408 Riboflavin kinase RFK 0.0026
788 Creatine kinase M-type CKM 0.0025
4366 Riboflavin kinase/FMN adenylyltransferase TM_0857 0.0025
6857 [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial PDK2 0.0025
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0025
3669 Ribokinase rbsK 0.0025
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0024
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.0024
6390 Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 ATP2A1 0.0023
2334 Dethiobiotin synthetase bioD 0.0023
6555 Dethiobiotin synthetase bioD 0.0023
2697 Uridine-cytidine kinase 2 UCK2 0.0022
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0022
61 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0021
2644 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0021
2710 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0021
48 Pyridoxal kinase PDXK 0.0021
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0021
2317 UDP-N-acetylmuramoylalanine--D-glutamate ligase murD 0.0021
702 UMP-CMP kinase CMPK1 0.0021
2091 Endoplasmin HSP90B1 0.002
6395 Myosin-14 MYH14 0.002
1422 Serine/threonine-protein kinase 6 AURKA 0.0019
3379 Kinesin-like protein KIF11 KIF11 0.0019
3456 Heat shock protein HSP 90-beta HSP90AB1 0.0019
504 Mast/stem cell growth factor receptor KIT 0.0019
509 Thymidine kinase TK 0.0018
570 Thymidine kinase TK 0.0018
2559 Thymidine kinase TK 0.0018
3430 Thymidine kinase tdk 0.0018
3518 Thymidine kinase TK 0.0018
5301 Thymidine kinase tdk 0.0018
5771 Thymidine kinase ORF36 0.0018
7009 Thymidine kinase ORF36 0.0018
5294 Nucleoside diphosphate kinase A NME1 0.0017
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0017
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0017
4773 Deoxycytidine kinase DCK 0.0017
5682 Ribonuclease pancreatic RNASE1 0.0016
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0014
↑