DT-Web

DB04207 - N-(5-Amino-5-Carboxypentyl)Glutamic Acid


Identification
Name N-(5-Amino-5-Carboxypentyl)Glutamic Acid
Accession Number DB04207 (EXPT02906)
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 276.2863
Groups experimental
Monoisotopic Weight 276.132136382
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Alpha-aminoadipic semialdehyde synthase, mitochondrial
Name Alpha-aminoadipic semialdehyde synthase, mitochondrial
Gene Name AASS
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.4948

Predictions


Id Partner name Gene Name Score
1799 Glucose-6-phosphate 1-dehydrogenase G6PD 0.0632
2630 Glucose-6-phosphate 1-dehydrogenase zwf 0.0632
2826 Glucose--fructose oxidoreductase gfo 0.0621
2675 Pteridine reductase 1 PTR1 0.0595
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0534
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0471
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.0078
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0067
4026 Aspartyl aminopeptidase DNPEP 0.0057
4024 Mitochondrial glutamate carrier 2 SLC25A18 0.0057
4025 Mitochondrial glutamate carrier 1 SLC25A22 0.0057
4022 Glutamate--ammonia ligase domain-containing protein 1 LGSN 0.0057
4023 N-acetylglutamate synthase, mitochondrial NAGS 0.0057
1912 Excitatory amino acid transporter 1 SLC1A3 0.0057
4016 Excitatory amino acid transporter 5 SLC1A7 0.0057
4019 Excitatory amino acid transporter 4 SLC1A6 0.0057
1047 Excitatory amino acid transporter 2 SLC1A2 0.0057
664 Glutamate decarboxylase 2 GAD2 0.0057
3890 Glutamate decarboxylase 2 GAD2 0.0057
4021 Probable glutamyl-tRNA synthetase, mitochondrial EARS2 0.0057
924 Glutamate receptor, ionotropic kainate 3 GRIK3 0.0057
4018 Glutamate receptor delta-2 subunit GRID2 0.0057
915 Delta 1-pyrroline-5-carboxylate synthetase ALDH18A1 0.0057
922 Glutamate receptor 4 GRIA4 0.0057
927 Metabotropic glutamate receptor 8 GRM8 0.0057
925 Metabotropic glutamate receptor 4 GRM4 0.0057
926 Metabotropic glutamate receptor 7 GRM7 0.0057
919 Glutamate receptor, ionotropic kainate 4 GRIK4 0.0057
4020 Glutamyl aminopeptidase ENPEP 0.0057
920 Glutamate receptor, ionotropic kainate 5 GRIK5 0.0057
4027 Glutamate receptor delta-1 subunit GRID1 0.0057
4017 5-oxoprolinase OPLAH 0.0057
625 Glutamate carboxypeptidase 2 FOLH1 0.0051
355 GMP synthase [glutamine-hydrolyzing] GMPS 0.0048
4353 GMP synthase [glutamine-hydrolyzing] guaA 0.0048
917 Glutaminase kidney isoform, mitochondrial GLS 0.0048
3991 Glutamine-dependent NAD(+) synthetase NADSYN1 0.0048
3984 Probable glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial PET112L 0.0048
5 Glutaminase liver isoform, mitochondrial GLS2 0.0048
3982 Phosphoribosylformylglycinamidine synthase PFAS 0.0048
5261 Phosphoribosylformylglycinamidine synthase purL 0.0048
668 Glutamate--cysteine ligase regulatory subunit GCLM 0.0048
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0046
916 Metabotropic glutamate receptor 1 GRM1 0.0046
3895 Kynurenine--oxoglutarate transaminase 3 CCBL2 0.0046
665 Phosphoserine aminotransferase PSAT1 0.0046
4652 Phosphoserine aminotransferase serC 0.0046
420 Glutamate decarboxylase 1 GAD1 0.0046
3900 Glutamate decarboxylase 1 GAD1 0.0046
801 Kynurenine/alpha-aminoadipate aminotransferase mitochondrial AADAT 0.0046
923 Glutamate receptor 3 GRIA3 0.0045
210 Bifunctional aminoacyl-tRNA synthetase [Includes: Glutamyl-tRNA synthetase EPRS 0.0045
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0043
1671 Excitatory amino acid transporter 3 SLC1A1 0.0043
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0042
186 Glutamate--cysteine ligase catalytic subunit GCLC 0.0042
914 Formimidoyltransferase-cyclodeaminase FTCD 0.0042
3877 Growth-inhibiting protein 18 GIG18 0.0042
426 Aspartate aminotransferase, mitochondrial GOT2 0.0042
586 Aspartate aminotransferase, cytoplasmic GOT1 0.004
795 Branched-chain-amino-acid aminotransferase, mitochondrial BCAT2 0.0039
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0039
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0039
763 Tyrosine aminotransferase TAT 0.0039
5493 Tyrosine aminotransferase Not Available 0.0039
735 Alanine aminotransferase 1 GPT 0.0039
3904 Alanine aminotransferase 2 GPT2 0.0039
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0038
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0037
33 Cystine/glutamate transporter SLC7A11 0.0037
574 Branched-chain-amino-acid aminotransferase, cytosolic BCAT1 0.0037
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0036
705 Glutamate receptor 1 GRIA1 0.0036
3426 Glutamine synthetase glnA 0.0036
3987 Glutamine synthetase GLUL 0.0036
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0035
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0034
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0033
738 Monocarboxylate transporter 1 SLC16A1 0.003
190 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4 NDUFA4 0.003
247 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 NDUFA1 0.003
343 NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial NDUFC1 0.003
324 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 NDUFB4 0.003
755 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 NDUFA3 0.003
313 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 NDUFB3 0.003
607 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 NDUFA2 0.003
300 NADH-ubiquinone oxidoreductase chain 4L MT-ND4L 0.003
374 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 NDUFB1 0.003
30 NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial NDUFV3 0.003
525 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 NDUFA5 0.003
219 NADH-ubiquinone oxidoreductase chain 3 MT-ND3 0.003
270 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial NDUFB5 0.003
104 NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial NDUFS6 0.003
417 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 NDUFB6 0.003
568 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 NDUFB7 0.003
582 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 NDUFA13 0.003
353 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 NDUFA4L2 0.003
602 Acyl carrier protein, mitochondrial NDUFAB1 0.003
405 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 NDUFA8 0.003
272 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 NDUFB10 0.003
384 NADH-ubiquinone oxidoreductase chain 6 MT-ND6 0.003
656 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 NDUFB9 0.003
829 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 NDUFA12 0.003
746 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial NDUFB8 0.003
475 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial NDUFB2 0.003
99 NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 NDUFS5 0.003
372 Estradiol 17-beta-dehydrogenase 3 HSD17B3 0.003
446 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 NDUFA7 0.003
644 Heme oxygenase 2 HMOX2 0.003
4982 Heme oxygenase 2 pbsA2 0.003
41 NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial NDUFS8 0.003
167 L-lactate dehydrogenase C chain LDHC 0.003
326 L-lactate dehydrogenase A-like 6A LDHAL6A 0.003
141 3-hydroxyisobutyrate dehydrogenase, mitochondrial HIBADH 0.003
236 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 NDUFA6 0.003
91 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial NDUFA10 0.003
608 NADH-ubiquinone oxidoreductase chain 4 MT-ND4 0.003
335 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial NDUFA9 0.003
112 L-lactate dehydrogenase A-like 6B LDHAL6B 0.003
598 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 NDUFA11 0.003
152 NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial NDUFV2 0.003
848 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial IDH3G 0.003
609 15-hydroxyprostaglandin dehydrogenase [NAD+] HPGD 0.003
107 C-4 methylsterol oxidase SC4MOL 0.003
216 Aldehyde dehydrogenase 3B2 ALDH3B2 0.003
9 Estradiol 17-beta-dehydrogenase 2 HSD17B2 0.003
555 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial NDUFS4 0.003
643 Peroxisomal bifunctional enzyme EHHADH 0.003
729 GDP-L-fucose synthetase TSTA3 0.003
3463 GDP-L-fucose synthetase fcl 0.003
487 Aldo-keto reductase family 1 member C4 AKR1C4 0.003
180 D-3-phosphoglycerate dehydrogenase PHGDH 0.003
3726 D-3-phosphoglycerate dehydrogenase serA 0.003
4291 D-3-phosphoglycerate dehydrogenase serA 0.003
206 3-keto-steroid reductase HSD17B7 0.003
196 D-beta-hydroxybutyrate dehydrogenase, mitochondrial BDH1 0.003
721 NADH-ubiquinone oxidoreductase chain 2 MT-ND2 0.003
231 Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic GPD1 0.003
496 Aldehyde dehydrogenase 3B1 ALDH3B1 0.003
14 Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial IDH3A 0.003
50 Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating NSDHL 0.003
662 Fatty aldehyde dehydrogenase ALDH3A2 0.003
616 Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial IDH3B 0.003
671 Pyruvate dehydrogenase E1 component alpha subunit, testis-specific form, mitochondrial PDHA2 0.003
628 Pyruvate dehydrogenase E1 component alpha subunit, somatic form, mitochondrial PDHA1 0.003
145 Corticosteroid 11-beta-dehydrogenase isozyme 2 HSD11B2 0.003
539 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial NDUFV1 0.003
548 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial NDUFS1 0.003
34 7-dehydrocholesterol reductase DHCR7 0.003
711 UDP-glucose 6-dehydrogenase UGDH 0.003
3672 UDP-glucose 6-dehydrogenase hasB 0.003
149 Alpha-aminoadipic semialdehyde dehydrogenase ALDH7A1 0.003
531 Aldehyde dehydrogenase X, mitochondrial ALDH1B1 0.003
258 Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial ALDH6A1 0.003
271 Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial ALDH4A1 0.003
637 NADH-ubiquinone oxidoreductase chain 5 MT-ND5 0.003
393 GDH/6PGL endoplasmic bifunctional protein [Includes: Glucose 1-dehydrogenase H6PD 0.003
288 Trifunctional enzyme subunit alpha, mitochondrial HADHA 0.003
816 Biliverdin reductase A BLVRA 0.0029
579 Alcohol dehydrogenase class 4 mu/sigma chain ADH7 0.0029
792 Aldehyde dehydrogenase, dimeric NADP-preferring ALDH3A1 0.0029
316 4-trimethylaminobutyraldehyde dehydrogenase ALDH9A1 0.0029
6151 Monocarboxylate transporter 10 SLC16A10 0.0028
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0027
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0027
921 Glutamate receptor 2 GRIA2 0.0027
635 Estradiol 17-beta-dehydrogenase 8 HSD17B8 0.0027
666 NADP-dependent malic enzyme ME1 0.0027
857 Malate dehydrogenase, mitochondrial MDH2 0.0027
350 3-hydroxyacyl-CoA dehydrogenase type-2 HSD17B10 0.0027
646 Malate dehydrogenase, cytoplasmic MDH1 0.0027
178 NADH-cytochrome b5 reductase 3 CYB5R3 0.0027
812 Dihydrolipoyl dehydrogenase, mitochondrial DLD 0.0027
454 Peroxisomal multifunctional enzyme type 2 HSD17B4 0.0027
363 NADP-dependent malic enzyme, mitochondrial ME3 0.0026
597 Dihydropteridine reductase QDPR 0.0026
328 Sorbitol dehydrogenase SORD 0.0026
396 Alcohol dehydrogenase 4 ADH4 0.0026
11 NAD(P) transhydrogenase, mitochondrial NNT 0.0025
839 Short-chain specific acyl-CoA dehydrogenase, mitochondrial ACADS 0.0025
419 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial HADH 0.0025
12 Alcohol dehydrogenase class 3 ADH5 0.0025
77 L-lactate dehydrogenase B chain LDHB 0.0025
74 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial DLAT 0.0024
626 Cysteine dioxygenase type 1 CDO1 0.0024
802 Pyrroline-5-carboxylate reductase 2 PYCR2 0.0024
248 Pyrroline-5-carboxylate reductase 1 PYCR1 0.0024
296 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial MTHFD2 0.0024
599 Glyceraldehyde-3-phosphate dehydrogenase GAPDH 0.0024
4426 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0024
4454 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0024
4489 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0024
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0024
6026 Alcohol dehydrogenase 6 ADH6 0.0024
473 L-lactate dehydrogenase A chain LDHA 0.0023
794 Glyceraldehyde-3-phosphate dehydrogenase, testis-specific GAPDHS 0.0023
110 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial PDHB 0.0023
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0023
13 Aminomethyltransferase, mitochondrial AMT 0.0023
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0023
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0023
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0023
627 11-cis retinol dehydrogenase RDH5 0.0023
640 Aldehyde dehydrogenase 1A3 ALDH1A3 0.0023
166 NAD-dependent malic enzyme, mitochondrial ME2 0.0022
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0022
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0022
679 C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 0.0022
569 Retinal dehydrogenase 2 ALDH1A2 0.0021
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0021
611 Retinal dehydrogenase 1 ALDH1A1 0.0021
654 Flavin reductase BLVRB 0.002
57 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I HSD3B1 0.002
251 Alcohol dehydrogenase 1A ADH1A 0.002
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.002
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0019
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0019
810 Heme oxygenase 1 HMOX1 0.0019
3391 Heme oxygenase 1 pbsA1 0.0019
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0019
279 Tyrosinase TYR 0.0019
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0019
444 Alcohol dehydrogenase 1B ADH1B 0.0019
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0018
714 Glutathione reductase, mitochondrial GSR 0.0018
380 Cytochrome P450 17A1 CYP17A1 0.0018
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0017
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0017
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0017
517 Alcohol dehydrogenase 1C ADH1C 0.0017
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0016
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0016
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0016
822 Aldose reductase AKR1B1 0.0016
365 Dihydrofolate reductase DHFR 0.0015
2381 Dihydrofolate reductase DFR1 0.0015
2833 Dihydrofolate reductase Not Available 0.0015
2931 Dihydrofolate reductase folA 0.0015
3544 Dihydrofolate reductase folA 0.0015
3682 Dihydrofolate reductase folA 0.0015
6642 Dihydrofolate reductase folA 0.0015
6756 Dihydrofolate reductase dfrA 0.0015
468 Cytochrome P450 4A11 CYP4A11 0.0015
6020 Aldehyde oxidase AOX1 0.0015
3947 Xanthine dehydrogenase/oxidase XDH 0.0014
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