DT-Web

DB02999 - Quisqualate


Identification
Name Quisqualate
Accession Number DB02999 (EXPT02735)
Type small molecule
Description An agonist at two subsets of excitatory amino acid receptors, ionotropic receptors that directly control membrane channels and metabotropic receptors that indirectly mediate calcium mobilization from intracellular stores. The compound is obtained from the seeds and fruit of Quisqualis chinensis. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 189.1262
Groups experimental
Monoisotopic Weight 189.038570349
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Glutamate receptor 2
Name Glutamate receptor 2
Gene Name GRIA2
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.908
Glutamate receptor, ionotropic kainate 2
Name Glutamate receptor, ionotropic kainate 2
Gene Name GRIK2
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.3711

Predictions


Id Partner name Gene Name Score
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.1416
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.1416
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.1218
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.1206
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.1155
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.1104
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.1103
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.1069
6016 Cytochrome P450 2C19 CYP2C19 0.0171
923 Glutamate receptor 3 GRIA3 0.0159
4512 Cytochrome P450 3A4 CYP3A4 0.014
4200 Cytochrome P450 1A2 CYP1A2 0.0121
4757 Cytochrome P450 2C9 CYP2C9 0.0117
6030 Cytochrome P450 2B6 CYP2B6 0.0106
6013 Cytochrome P450 2E1 CYP2E1 0.0101
172 Potassium channel subfamily K member 1 KCNK1 0.0095
4924 Cytochrome P450 2C8 CYP2C8 0.0094
3937 Fatty-acid amide hydrolase FAAH 0.0092
5718 Cytochrome P450 2A6 CYP2A6 0.0081
502 5-hydroxytryptamine 2A receptor HTR2A 0.0065
831 D(2) dopamine receptor DRD2 0.0064
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0059
20 Prostaglandin G/H synthase 1 PTGS1 0.0039
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0032
468 Cytochrome P450 4A11 CYP4A11 0.0032
6106 Cytochrome P450 2C18 CYP2C18 0.0026
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0026
1898 Cytochrome P450 1B1 CYP1B1 0.0025
776 Bile salt export pump ABCB11 0.0025
924 Glutamate receptor, ionotropic kainate 3 GRIK3 0.0024
862 Multidrug resistance-associated protein 1 ABCC1 0.0023
922 Glutamate receptor 4 GRIA4 0.0023
920 Glutamate receptor, ionotropic kainate 5 GRIK5 0.0022
919 Glutamate receptor, ionotropic kainate 4 GRIK4 0.0022
4027 Glutamate receptor delta-1 subunit GRID1 0.0022
4018 Glutamate receptor delta-2 subunit GRID2 0.0022
4025 Mitochondrial glutamate carrier 1 SLC25A22 0.0022
4024 Mitochondrial glutamate carrier 2 SLC25A18 0.0022
1912 Excitatory amino acid transporter 1 SLC1A3 0.0022
664 Glutamate decarboxylase 2 GAD2 0.0022
3890 Glutamate decarboxylase 2 GAD2 0.0022
4016 Excitatory amino acid transporter 5 SLC1A7 0.0022
4019 Excitatory amino acid transporter 4 SLC1A6 0.0022
1047 Excitatory amino acid transporter 2 SLC1A2 0.0022
4026 Aspartyl aminopeptidase DNPEP 0.0022
4022 Glutamate--ammonia ligase domain-containing protein 1 LGSN 0.0022
4021 Probable glutamyl-tRNA synthetase, mitochondrial EARS2 0.0022
4023 N-acetylglutamate synthase, mitochondrial NAGS 0.0022
925 Metabotropic glutamate receptor 4 GRM4 0.0022
926 Metabotropic glutamate receptor 7 GRM7 0.0022
927 Metabotropic glutamate receptor 8 GRM8 0.0022
915 Delta 1-pyrroline-5-carboxylate synthetase ALDH18A1 0.0022
4020 Glutamyl aminopeptidase ENPEP 0.0022
4017 5-oxoprolinase OPLAH 0.0022
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0021
6024 Cytochrome P450 1A1 CYP1A1 0.002
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.002
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.002
625 Glutamate carboxypeptidase 2 FOLH1 0.002
6107 Cytochrome P450 3A7 CYP3A7 0.0019
3984 Probable glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial PET112L 0.0019
5 Glutaminase liver isoform, mitochondrial GLS2 0.0019
917 Glutaminase kidney isoform, mitochondrial GLS 0.0019
355 GMP synthase [glutamine-hydrolyzing] GMPS 0.0019
4353 GMP synthase [glutamine-hydrolyzing] guaA 0.0019
3991 Glutamine-dependent NAD(+) synthetase NADSYN1 0.0019
3982 Phosphoribosylformylglycinamidine synthase PFAS 0.0019
5261 Phosphoribosylformylglycinamidine synthase purL 0.0019
668 Glutamate--cysteine ligase regulatory subunit GCLM 0.0019
665 Phosphoserine aminotransferase PSAT1 0.0019
4652 Phosphoserine aminotransferase serC 0.0019
3895 Kynurenine--oxoglutarate transaminase 3 CCBL2 0.0019
801 Kynurenine/alpha-aminoadipate aminotransferase mitochondrial AADAT 0.0019
420 Glutamate decarboxylase 1 GAD1 0.0019
3900 Glutamate decarboxylase 1 GAD1 0.0019
4118 Cytochrome P450 3A5 CYP3A5 0.0018
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0018
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0018
916 Metabotropic glutamate receptor 1 GRM1 0.0018
1671 Excitatory amino acid transporter 3 SLC1A1 0.0017
186 Glutamate--cysteine ligase catalytic subunit GCLC 0.0017
83 Alpha-aminoadipic semialdehyde synthase, mitochondrial AASS 0.0017
3877 Growth-inhibiting protein 18 GIG18 0.0017
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0017
210 Bifunctional aminoacyl-tRNA synthetase [Includes: Glutamyl-tRNA synthetase EPRS 0.0017
914 Formimidoyltransferase-cyclodeaminase FTCD 0.0017
426 Aspartate aminotransferase, mitochondrial GOT2 0.0017
1588 Multidrug resistance protein 1 ABCB1 0.0017
763 Tyrosine aminotransferase TAT 0.0016
5493 Tyrosine aminotransferase Not Available 0.0016
735 Alanine aminotransferase 1 GPT 0.0016
3904 Alanine aminotransferase 2 GPT2 0.0016
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0016
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0016
586 Aspartate aminotransferase, cytoplasmic GOT1 0.0016
705 Glutamate receptor 1 GRIA1 0.0016
795 Branched-chain-amino-acid aminotransferase, mitochondrial BCAT2 0.0016
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0015
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0015
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0015
574 Branched-chain-amino-acid aminotransferase, cytosolic BCAT1 0.0015
33 Cystine/glutamate transporter SLC7A11 0.0015
3426 Glutamine synthetase glnA 0.0015
3987 Glutamine synthetase GLUL 0.0015
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0015
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0014
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0014
738 Monocarboxylate transporter 1 SLC16A1 0.0012
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0012
6151 Monocarboxylate transporter 10 SLC16A10 0.0011
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