DT-Web: DB08820

Identification

Name

Ivacaftor

Accession Number

DB08820

Type

small molecule

Description

Ivacaftor (also known as Kalydeco or VX-770) is a drug for the treatment of cystic fibrosis, developed by Vertex Pharmaceuticals and the Cystic Fibrosis Foundation. FDA approved on January 31, 2012.

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Respiratory System Agents

Molecular Weight

392.4907

Groups

approved

Monoisotopic Weight

392.209992772

Pharmacology

Indication

For the treatment of cystic fibrosis (CF) in patients age 6 years and older who have a G551D mutation in the CFTR gene.

Mechanism of action

Cystic fibrosis is caused by any one of several defects in a protein, cystic fibrosis transmembrane conductance regulator, which regulates fluid flow within cells and affects the components of sweat, digestive fluids, and mucus. The defect, which is caused by a mutation in the individual's DNA, can be in any of several locations along the protein, each of which interferes with a different function of the protein. One mutation, G551D, lets the CFTR protein reach the epithelial cell surface, but doesn't let it transport chloride through the ion channel. Ivacaftor is a potentiator of the CFTR protein. The CFTR protein is a chloride channel present at the surface of epithelial cells in multiple organs. Ivacaftor facilitates increased chloride transport by potentiating the channel-open probability (or gating) of the G551D-CFTR protein.

Absorption

The pharmacokinetics of ivacaftor is similar between healthy adult volunteers and patients with CF. When given a single oral dose of 150 mg to healthy subjects, the parameters were as follows: Tmax = 4 hours; Cmax = 768 ng/mL; AUC = 10600 ng*hr/mL; Time to steady state, 12 hour dosing = 3-5 days Following repeated doses for ivacaftor, accumulation occurs. When given with a fatty meal, exposure increases 2-4 fold.

Protein binding

Ivacaftor is approximately 99% bound to plasma proteins, primarily to alpha 1-acid glycoprotein and albumin. Ivacaftor does not bind to human red blood cells.

Biotransformation

Ivacaftor is extensively metabolized in humans. In vitro and clinical studies indicate that ivacaftor is primarily metabolized by CYP3A. M1 and M6 are the two major metabolites of ivacaftor in humans. M1 has approximately one-sixth the potency of ivacaftor and is considered pharmacologically active. M6 has less than one-fiftieth the potency of ivacaftor and is not considered pharmacologically active.

Route of elimination

Following oral administration, the majority of ivacaftor (87.8%) is eliminated in the feces after metabolic conversion. The major metabolites M1 and M6 accounted for approximately 65% of the total dose eliminated with 22% as M1 and 43% as M6. There was negligible urinary excretion of ivacaftor as unchanged parent.

Toxicity

There have been no reports of overdose with Ivacaftor. The highest single dose used in a clinical study was 800 mg in a solution formulation without any treatment-related adverse events.

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Alvimopan	Decreases levels by P-glycoprotein (MDR-1) efflux transporter. Can significantly increase systemic exposure to P-glycoprotein substrates.
Bendamustine	Increases levels of bendamustine by P-glycoprotein (MDR-1) efflux transporter.
Carbamazepine	Strong CYP3A4 inducers may decrease levels of ivacaftor. Monitor concomitant therapy closely.
Clarithromycin	Strong CYP3A4 inhibitors may increase levels of ivacaftor. Monitor concomitant therapy closely.
Erythromycin	Moderate CYP3A4 inhibitors may increase levels of ivacaftor. Consider dose reduction.
Etravirine	Ivacaftor, when used concomitantly with etravirine (a strong CYP3A4 inducer), may experience a decrease in serum concentration. It is recommended to avoid this combination.
Fluconazole	Moderate CYP3A4 inhibitors may increase levels of ivacaftor. Consider dose reduction.
Itraconazole	Strong CYP3A4 inhibitors may increase levels of ivacaftor. Monitor concomitant therapy closely.
Ketoconazole	Strong CYP3A4 inhibitors may increase levels of ivacaftor. Monitor concomitant therapy closely.
Pazopanib	Inhibits p-glycoprotein and affects heptatic metabolism via CYP3A4 therefore increases levels of pazopanib. Consider alternate therapy.
Phenobarbital	Strong CYP3A4 inducers may decrease levels of ivacaftor. Monitor concomitant therapy closely.
Phenytoin	Strong CYP3A4 inducers may decrease levels of ivacaftor. Monitor concomitant therapy closely.
Posaconazole	Strong CYP3A4 inhibitors may increase levels of ivacaftor. Monitor concomitant therapy closely.
Rifabutin	Strong CYP3A4 inducers may decrease levels of ivacaftor. Monitor concomitant therapy closely.
Rifampin	Strong CYP3A4 inducers may decrease levels of ivacaftor. Monitor concomitant therapy closely.
St. John's Wort	Strong CYP3A4 inducers may decrease levels of ivacaftor. Monitor concomitant therapy closely.
Telithromycin	Strong CYP3A4 inhibitors may increase levels of ivacaftor. Monitor concomitant therapy closely.
Tofacitinib	Ivacaftor, when used in combination with tofacitinib, may increase tofaciitinib concentrations, It is recommended to monitor therapy for signs of toxicity or worsened side effects.
Vismodegib	P-glycoprotein inhibitors may increase the chance of adverse drug reactions. Consider using alternative therapy.
Voriconazole	Strong CYP3A4 inhibitors may increase levels of ivacaftor. Monitor concomitant therapy closely.

Food Interactions

Exposure increases 2- to 4- fold when given with a high fat meal. It is recommended that ivacaftor be given this way.

Cystic fibrosis transmembrane conductance regulator
Name	Cystic fibrosis transmembrane conductance regulator
Gene Name	CFTR
Pharmacological action	yes
Actions	potentiator
References	Yu H, Burton B, Huang CJ, Worley J, Cao D, Johnson JP Jr, Urrutia A, Joubran J, Seepersaud S, Sussky K, Hoffman BJ, Van Goor F: Ivacaftor potentiation of multiple CFTR channels with gating mutations. J Cyst Fibros. 2012 Jan 30. - Pubmed
DTHybrid score	0.3376

Cytochrome P450 3A4
Name	Cytochrome P450 3A4
Gene Name	CYP3A4
Actions	substrate,inhibitor
References	FDA Label -
DTHybrid score	0.4172

Multidrug resistance protein 1
Name	Multidrug resistance protein 1
Gene Name	ABCB1
Actions	inhibitor
References	FDA Label -
DTHybrid score	0.3375

Multidrug resistance protein 1
Name	Multidrug resistance protein 1
Gene Name	ABCB1
Actions
References	Not Available
DTHybrid score	0.3375

Id	Partner name	Gene Name	Score
4119	Cytochrome P450 2D6	CYP2D6	0.1525
4757	Cytochrome P450 2C9	CYP2C9	0.1335
6016	Cytochrome P450 2C19	CYP2C19	0.1203
4118	Cytochrome P450 3A5	CYP3A5	0.1157
4924	Cytochrome P450 2C8	CYP2C8	0.1071
4200	Cytochrome P450 1A2	CYP1A2	0.106
6107	Cytochrome P450 3A7	CYP3A7	0.0762
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.0739
6030	Cytochrome P450 2B6	CYP2B6	0.0657
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.0614
1729	Solute carrier family 22 member 6	SLC22A6	0.0565
862	Multidrug resistance-associated protein 1	ABCC1	0.0512
6013	Cytochrome P450 2E1	CYP2E1	0.0503
6024	Cytochrome P450 1A1	CYP1A1	0.0464
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.0449
290	Prostaglandin G/H synthase 2	PTGS2	0.0441
20	Prostaglandin G/H synthase 1	PTGS1	0.044
556	Alpha-1A adrenergic receptor	ADRA1A	0.0436
6142	Solute carrier family 22 member 8	SLC22A8	0.0382
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.0377
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.0371
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0363
6145	Solute carrier family 22 member 1	SLC22A1	0.0343
6143	Solute carrier family 22 member 7	SLC22A7	0.0325
824	Sodium-dependent serotonin transporter	SLC6A4	0.0324
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0321
1024	Solute carrier family 22 member 11	SLC22A11	0.032
492	Histamine H1 receptor	HRH1	0.0308
5718	Cytochrome P450 2A6	CYP2A6	0.0299
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0293
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.029
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0289
871	Glucocorticoid receptor	NR3C1	0.0277
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0267
632	Alpha-1B adrenergic receptor	ADRA1B	0.0266
831	D(2) dopamine receptor	DRD2	0.0259
789	Alpha-1D adrenergic receptor	ADRA1D	0.0259
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0258
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0258
2164	Multidrug resistance-associated protein 4	ABCC4	0.0254
6144	Solute carrier family 22 member 2	SLC22A2	0.0253
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0247
6141	Sodium/bile acid cotransporter	SLC10A1	0.0237
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0232
776	Bile salt export pump	ABCB11	0.023
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0229
193	Beta-1 adrenergic receptor	ADRB1	0.0228
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0225
844	Epidermal growth factor receptor	EGFR	0.022
891	Dihydropteroate synthase	folP	0.022
5359	Dihydropteroate synthase	folP	0.022
7175	Dihydropteroate synthase	sulI	0.022
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0217
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0217
766	Beta-2 adrenergic receptor	ADRB2	0.0212
136	Estrogen receptor	ESR1	0.0206
3811	Cytochrome P450 19A1	CYP19A1	0.0206
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0205
318	Alpha-2A adrenergic receptor	ADRA2A	0.0205
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0204
6106	Cytochrome P450 2C18	CYP2C18	0.0203
23	D(1A) dopamine receptor	DRD1	0.0198
847	Mu-type opioid receptor	OPRM1	0.0195
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0194
3923	Cholinesterase	BCHE	0.0193
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0188
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0184
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0182
1898	Cytochrome P450 1B1	CYP1B1	0.0173
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0171
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0171
53	Solute carrier family 12 member 5	SLC12A5	0.0171
663	Solute carrier family 12 member 4	SLC12A4	0.0171
1389	Transforming growth factor beta-1	TGFB1	0.0169
731	HIV-1 protease	HIV-1 protease	0.0163
558	Solute carrier family 12 member 1	SLC12A1	0.0162
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0159
118	Organic cation/carnitine transporter 2	SLC22A5	0.0158
310	Solute carrier family 12 member 2	SLC12A2	0.0158
465	Calmodulin	CALM1	0.0158
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0156
2514	Phosphocarrier protein HPr	ptsH	0.0154
5689	Phosphocarrier protein HPr	ptsH	0.0154
3602	Anti-sigma F factor antagonist	spoIIAA	0.0154
5686	Potassium voltage-gated channel subfamily C member 4	KCNC4	0.0154
696	Kappa-type opioid receptor	OPRK1	0.015
6085	Fatty acid-binding protein, intestinal	FABP2	0.0146
6541	Peptostreptococcal albumin-binding protein	pab	0.0142
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0141
713	Sodium-dependent dopamine transporter	SLC6A3	0.014
467	Delta-type opioid receptor	OPRD1	0.0135
1130	Lithostathine 1 alpha	REG1A	0.0134
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0134
4542	Glutaminase 1	glsA1	0.0134
4544	Glutaminase 1	glsA1	0.0134
2530	Protein kinase C theta type	PRKCQ	0.0131
4318	Siroheme synthase	cysG	0.013
2347	Proto-oncogene serine/threonine-protein kinase Pim-1	PIM1	0.0125
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0125
3119	Fimbrial protein	pilE1	0.0125
6147	Solute carrier family 22 member 3	SLC22A3	0.0123
756	Sex hormone-binding globulin	SHBG	0.0119
614	Progesterone receptor	PGR	0.0118
4604	Liver carboxylesterase 1	CES1	0.0117
1517	Beta-3 adrenergic receptor	ADRB3	0.0116
3453	Alkaline phosphatase	phoA	0.0116
2021	Thrombomodulin	THBD	0.0115
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0114
5150	Endo-1,4-beta-xylanase Y	xynY	0.0113
2207	Rhodopsin	RHO	0.0113
260	Cytochrome P450 51	ERG11	0.0112
761	Cytochrome P450 51	ERG11	0.0112
3163	Cytochrome P450 51	cyp51	0.0112
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0112
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.011
2503	Phosphomannomutase/phosphoglucomutase	algC	0.011
183	Vascular endothelial growth factor A	VEGFA	0.0109
380	Cytochrome P450 17A1	CYP17A1	0.0109
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0106
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0106
3941	Amine oxidase [flavin-containing] A	MAOA	0.0105
768	FK506-binding protein 1A	FKBP1A	0.0105
2211	Fatty acid-binding protein, heart	FABP3	0.0105
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0104
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0104
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0103
817	DNA topoisomerase 2-alpha	TOP2A	0.0102
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0102
629	Alpha-2B adrenergic receptor	ADRA2B	0.0101
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0101
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0101
132	ATP-binding cassette sub-family A member 1	ABCA1	0.01
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.01
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.01
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0099
122	P2Y purinoceptor 12	P2RY12	0.0098
273	Apoptosis regulator Bcl-2	BCL2	0.0098
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0097
504	Mast/stem cell growth factor receptor	KIT	0.0097
833	Organic cation/carnitine transporter 1	SLC22A4	0.0096
3939	Amine oxidase [flavin-containing] B	MAOB	0.0095
566	Serotransferrin	TF	0.0094
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0094
1050	Bile salt sulfotransferase	SULT2A1	0.0094
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0094
232	Corticosteroid-binding globulin	SERPINA6	0.0091
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0091
10	Glycogen phosphorylase, liver form	PYGL	0.0091
378	Alpha-2C adrenergic receptor	ADRA2C	0.0091
725	5-hydroxytryptamine 1D receptor	HTR1D	0.009
738	Monocarboxylate transporter 1	SLC16A1	0.009
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0089
1656	CYP2B protein	CYP2B	0.0088
6182	Cytochrome P450 2J2	CYP2J2	0.0088
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0088
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0088
70	Type-1 angiotensin II receptor	AGTR1	0.0087
373	Transthyretin	TTR	0.0086
5787	Angiopoietin-1 receptor	TEK	0.0085
705	Glutamate receptor 1	GRIA1	0.0085
146	Androgen receptor	AR	0.0085
1792	Tissue-type plasminogen activator	PLAT	0.0085
818	50S ribosomal protein L10	rplJ	0.0085
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0085
244	Angiotensin-converting enzyme	ACE	0.0084
869	Estrogen receptor beta	ESR2	0.0084
638	D(3) dopamine receptor	DRD3	0.0083
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0083
5646	Galactokinase	GALK1	0.0081
3390	Aminoglycoside 3'-phosphotransferase	aphA	0.0081
6029	Aminoglycoside 3'-phosphotransferase	aphA1	0.0081
5302	TrwB	trwB	0.0081
5265	FtsH	ftsH	0.0081
6525	Group IID secretory phospholipase A2	PLA2G2D	0.008
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0079
645	Penicillin-binding protein 1A	mrcA	0.0078
5805	Penicillin-binding protein 1A	ponA	0.0078
6185	Penicillin-binding protein 1A	mrcA	0.0078
6799	Penicillin-binding protein 1A	pbpA	0.0078
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0077
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0077
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0077
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0077
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0077
952	Dipeptidyl peptidase 4	DPP4	0.0077
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0076
6137	Multidrug resistance-associated protein 6	ABCC6	0.0076
6148	Multidrug resistance-associated protein 7	ABCC10	0.0076
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0076
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0076
6263	cAMP-dependent protein kinase catalytic subunit alpha	PRKACA	0.0075
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0075
124	Histamine H2 receptor	HRH2	0.0075
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0074
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0074
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0074
474	Acetylcholinesterase	ACHE	0.0073
161	Tubulin beta chain	TUBB	0.0073
312	Tubulin beta chain	TUB2	0.0073
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0073
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0073
5312	Kinesin-like protein KIF1A	KIF1A	0.0073
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0072
543	Penicillin-binding protein 1B	mrcB	0.0072
6186	Penicillin-binding protein 1B	ponB	0.0072
6822	Penicillin-binding protein 1b	pbp1b	0.0072
6844	Penicillin-binding protein 1b	pbp1b	0.0072
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0072
1353	DNA topoisomerase 1	TOP1	0.0072
3552	DNA topoisomerase 1	topA	0.0072
482	Glycine receptor subunit alpha-1	GLRA1	0.0072
1	Peptidoglycan synthetase ftsI	ftsI	0.0071
4155	Peptidoglycan synthetase ftsI	ftsI	0.0071
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0071
1152	Glycogen phosphorylase, muscle form	PYGM	0.007
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.007
811	Translocator protein	TSPO	0.0069
2892	Acetylglutamate kinase	argB	0.0068
3550	Acetylglutamate kinase	argB	0.0068
2371	Pantothenate kinase	coaA	0.0068
2615	Chemotaxis protein cheA	cheA	0.0068
2950	Inositol-trisphosphate 3-kinase A	ITPKA	0.0067
1881	Hexokinase-1	HK1	0.0067
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0067
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0066
36	Insulin receptor	INSR	0.0066
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0066
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0066
29	Tubulin beta-1 chain	TUBB1	0.0066
6832	Serine/threonine-protein kinase SRPK2	SRPK2	0.0065
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0065
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0065
716	5-hydroxytryptamine 7 receptor	HTR7	0.0065
1618	High affinity nerve growth factor receptor	NTRK1	0.0064
2727	S-adenosylmethionine synthetase	metK	0.0064
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0064
3432	Multidrug-efflux transporter 1 regulator	bmrR	0.0063
4476	Mannitol dehydrogenase	mtlD	0.0063
1119	Peroxiredoxin-5, mitochondrial	PRDX5	0.0063
6432	Transporter	snf	0.0063
468	Cytochrome P450 4A11	CYP4A11	0.0062
4237	50S ribosomal protein L22	rplV	0.0062
6031	Cytochrome P450 3A43	CYP3A43	0.0062
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0062
4120	NADPH--cytochrome P450 reductase	POR	0.0062
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0062
2817	Phosphoribosylglycinamide formyltransferase 2	purT	0.0061
6136	Multidrug resistance-associated protein 5	ABCC5	0.0061
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0061
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0061
1757	Myeloperoxidase	MPO	0.0061
936	Ephrin type-A receptor 2	EPHA2	0.0061
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0061
1192	Sulfotransferase 1A1	SULT1A1	0.006
185	Vasopressin V1a receptor	AVPR1A	0.006
4178	DNA repair protein RAD51 homolog 1	RAD51	0.006
5643	General secretion pathway protein E	epsE	0.006
3794	Osmolarity sensor protein envZ	envZ	0.006
5644	Sensor protein phoQ	phoQ	0.006
5641	Rod shape-determining protein MreB	TM_0588	0.006
5649	Potassium-transporting ATPase B chain	kdpB	0.0059
5642	Chaperone clpB	clpB	0.0059
5645	DNA topoisomerase 4 subunit B	parE	0.0059
6227	DNA topoisomerase 4 subunit B	parE	0.0059
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.0059
3382	Glycolipid transfer protein	GLTP	0.0058
6043	Putative G-protein coupled receptor 44	GPR44	0.0058
322	Vasopressin V2 receptor	AVPR2	0.0058
207	Glutathione synthetase	GSS	0.0057
5269	Glutathione synthetase	gshB	0.0057
3932	Glutathione S-transferase A2	GSTA2	0.0057
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0057
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0057
2852	DNA mismatch repair protein mutL	mutL	0.0057
2449	Tubulin alpha-3 chain	TUBA1A	0.0056
2251	Thymidylate kinase	tmk	0.0056
2254	Thymidylate kinase	DTYMK	0.0056
3522	Thymidylate kinase	tmk	0.0056
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0055
432	D(4) dopamine receptor	DRD4	0.0055
4192	DNA topoisomerase 2-beta	TOP2B	0.0054
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0054
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0054
477	DNA topoisomerase 4 subunit A	parC	0.0054
886	DNA topoisomerase 4 subunit A	parC	0.0054
6226	DNA topoisomerase 4 subunit A	parC	0.0054
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0053
404	DNA gyrase subunit A	gyrA	0.0053
6224	DNA gyrase subunit A	gyrA	0.0053
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0053
1721	Glycogen synthase kinase-3 beta	GSK3B	0.0053
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0053
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0053
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0053
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0053
594	Thyroxine-binding globulin	SERPINA7	0.0053
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0053
2853	14 kDa fatty acid-binding protein	Not Available	0.0053
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0052
4373	Medium-chain-fatty-acid--CoA ligase	Not Available	0.0052
4751	Mitogen-activated protein kinase 12	MAPK12	0.0052
2867	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase	ispE	0.0052
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0052
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0052
2397	Dihydroxyacetone kinase	dhaK	0.0052
6433	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4	PFKFB4	0.0052
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.0051
407	Vascular endothelial growth factor receptor 2	KDR	0.0051
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0051
3822	Actin, alpha skeletal muscle	ACTA1	0.0051
2616	Ganglioside GM2 activator	GM2A	0.0051
2499	Tubulin beta-2C chain	TUBB2C	0.0051
777	Tumor necrosis factor	TNF	0.005
737	Mineralocorticoid receptor	NR3C2	0.005
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.005
6027	Alkaline phosphatase, tissue-nonspecific isozyme	ALPL	0.005
758	Thyroid hormone receptor alpha	THRA	0.0049
5300	Antigen peptide transporter 1	TAP1	0.0049
3231	Death-associated protein kinase 1	DAPK1	0.0049
6184	D-alanyl-D-alanine carboxypeptidase dacC	dacC	0.0048
2299	UDP-N-acetylmuramate--L-alanine ligase	murC	0.0048
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0047
26	Vascular endothelial growth factor receptor 3	FLT4	0.0047
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0047
4238	50S ribosomal protein L4	rplD	0.0047
5578	50S ribosomal protein L4	rplD	0.0047
6173	50S ribosomal protein L4	rplD	0.0047
6219	50S ribosomal protein L4	rplD	0.0047
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0047
459	Retinoic acid receptor RXR-alpha	RXRA	0.0047
683	Potassium transporter	GK0582	0.0047
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0046
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0046
887	DNA gyrase subunit B	gyrB	0.0046
4150	DNA gyrase subunit B	gyrB	0.0046
6225	DNA gyrase subunit B	gyrB	0.0046
32	Vascular endothelial growth factor receptor 1	FLT1	0.0045
68	Cannabinoid receptor 1	CNR1	0.0045
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0045
6102	Arylamine N-acetyltransferase 2	NAT2	0.0045
115	Penicillin-binding protein 2	mrdA	0.0044
6069	Penicillin-binding protein 2	mrdA	0.0044
6118	Penicillin-binding protein 2	penA	0.0044
6187	Penicillin-binding protein 2	pbpA	0.0044
6686	Penicillin-binding protein 2	pbp2	0.0044
6939	Penicillin-binding protein 2	mrdA	0.0044
7163	Penicillin-binding protein 2	pbpA	0.0044
346	Thyroid hormone receptor beta-1	THRB	0.0044
2178	Metabotropic glutamate receptor 5	GRM5	0.0044
3947	Xanthine dehydrogenase/oxidase	XDH	0.0044
958	Insulin-like growth factor 1 receptor	IGF1R	0.0043
633	Penicillin-binding proteins 1A/1B	pbpA	0.0043
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0043
6138	Multidrug resistance protein 3	ABCB4	0.0043
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0042
1852	Microtubule-associated protein 2	MAP2	0.0042
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0041
163	D(1B) dopamine receptor	DRD5	0.0041
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0041
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.004
6020	Aldehyde oxidase	AOX1	0.004
528	5-hydroxytryptamine 1E receptor	HTR1E	0.004
6508	Putative uncharacterized protein	srtB	0.004
6543	Putative uncharacterized protein	tcp14	0.004
6615	Putative uncharacterized protein	MT0785	0.004
6623	Putative uncharacterized protein	Not Available	0.004
6806	Putative uncharacterized protein	AGR_C_2535	0.004
6813	Putative uncharacterized protein	SAV4671	0.004
6815	Putative uncharacterized protein	AFE_1514	0.004
6819	Putative uncharacterized protein	RUMGNA_03254	0.004
6825	Putative uncharacterized protein	CV_3270	0.004
1864	RET proto-oncogene	RET	0.004
4161	Furin	FURIN	0.004
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.004
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.004
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.004
6149	Solute carrier family 22 member 10	SLC22A10	0.0039
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0039
814	Ryanodine receptor 1	RYR1	0.0039
1129	C-C chemokine receptor type 5	CCR5	0.0039
24	Thymidylate synthase	TMP1	0.0039
359	Thymidylate synthase	TYMS	0.0039
2626	Thymidylate synthase	thyA	0.0039
2729	Thymidylate synthase	thyA	0.0039
5352	Thymidylate synthase	THYA	0.0039
6067	Penicillin binding protein 2a	mecA	0.0038
6677	Myelin P2 protein	PMP2	0.0038
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0038
2539	Tubulin alpha-1 chain	TUBA4A	0.0037
723	Cytosolic phospholipase A2	PLA2G4A	0.0037
780	Retinoic acid receptor RXR-gamma	RXRG	0.0037
1525	Heparin-binding growth factor 2	FGF2	0.0037
2236	Casein kinase II subunit alpha	CSNK2A1	0.0037
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0037
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0036
819	Penicillin-binding protein 4	dacB	0.0036
904	Glutathione S-transferase P	GSTP1	0.0036
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0036
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.0036
4773	Deoxycytidine kinase	DCK	0.0036
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0035
4210	Toll-like receptor 4	TLR4	0.0035
856	Vitamin D3 receptor	VDR	0.0035
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0035
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0035
939	50S ribosomal protein L3	rplC	0.0035
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0035
1836	Mitogen-activated protein kinase 10	MAPK10	0.0034
88	Retinoic acid receptor RXR-beta	RXRB	0.0034
357	Carbonic anhydrase 2	CA2	0.0034
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.0033
233	Potassium channel subfamily K member 2	KCNK2	0.0033
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0033
707	72 kDa type IV collagenase	MMP2	0.0033
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0032
702	UMP-CMP kinase	CMPK1	0.0032
1867	Major prion protein	PRNP	0.0032
284	DNA-directed RNA polymerase beta chain	rpoB	0.0032
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0032
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0032
592	Carbonic anhydrase 4	CA4	0.0032
1291	cAMP response element-binding protein	CREB1	0.0032
2107	Microtubule-associated protein 1A	MAP1A	0.0032
595	Fibrinogen alpha chain	FGA	0.0032
140	30S ribosomal protein S9	rpsI	0.0031
6719	30S ribosomal protein S9	rpsI	0.0031
6725	30S ribosomal protein S9	rpsI	0.0031
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0031
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0031
199	Monocarboxylate transporter 8	SLC16A2	0.0031
3760	Penicillin-binding protein 5 precursor	dacA	0.0031
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0031
5287	Signaling protein	Not Available	0.003
5288	Shikimate kinase	aroK	0.003
5314	UPF0079 ATP-binding protein HI0065	HI_0065	0.003
5304	UPF0166 protein TM_0021	TM_0021	0.003
3199	Phosphopantetheine adenylyltransferase	coaD	0.003
3543	Phosphopantetheine adenylyltransferase	coaD	0.003
3567	Phosphopantetheine adenylyltransferase	coaD	0.003
5289	Phosphopantetheine adenylyltransferase	coaD	0.003
4346	Polynucleotide kinase	pseT	0.003
5293	Shikimate kinase 2	aroL	0.003
5283	D-alanine--D-alanine ligase B	ddlB	0.003
5281	Plasmid segregation protein parM	parM	0.003
5305	Phosphoribosylaminoimidazole carboxylase ATPase subunit	purK	0.003
5292	Putative partitioning protein	TT_C1605	0.003
5276	Chromosomal replication initiator protein dnaA	dnaA	0.003
5266	Activator of	hgdC	0.003
5290	ATP-dependent hsl protease ATP-binding subunit hslU	hslU	0.003
5638	ATP-dependent hsl protease ATP-binding subunit hslU	hslU	0.003
5270	ATP-dependent Clp protease ATP-binding subunit clpX	clpX	0.003
2874	Nitrogenase iron protein 1	nifH1	0.003
5299	D-alanine--D-alanine ligase	ddl	0.003
6598	D-alanine--D-alanine ligase	ddl	0.003
5275	Multidrug resistance ABC transporter ATP-binding and permease protein	lmrA	0.003
1549	Heat shock 70 kDa protein 1	HSPA1A	0.003
5308	Preprotein translocase secA 1 subunit	secA1	0.003
5259	Transcriptional regulator	ntrC1	0.003
6699	Transcriptional regulator	Cgl2612	0.003
5284	Large T antigen	Not Available	0.003
5291	Glycogen synthase 1	glgA1	0.003
3777	ATP-dependent Clp protease ATP-binding subunit clpA	clpA	0.003
5264	DNA replication protein	REP	0.003
5277	Preprotein translocase subunit secA	secA	0.003
4794	Phosphoenolpyruvate carboxykinase [ATP]	pckA	0.003
5285	Kinesin heavy chain	KIF5B	0.003
5315	Chaperone protein htpG	htpG	0.003
3982	Phosphoribosylformylglycinamidine synthase	PFAS	0.003
5261	Phosphoribosylformylglycinamidine synthase	purL	0.003
6014	Cytochrome P450 2A13	CYP2A13	0.003
2578	Tubulin beta-3 chain	TUBB3	0.003
2285	Streptogramin A acetyltransferase	vatD	0.003
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.003
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.003
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.003
239	Coagulation factor X	F10	0.003
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.003
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.003
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.003
295	Carbonic anhydrase 1	CA1	0.003
1714	Mitogen-activated protein kinase 3	MAPK3	0.0029
6103	Arylamine N-acetyltransferase 1	NAT1	0.0029
3813	Fibrinogen gamma chain	FGG	0.0029
3812	Fibrinogen beta chain [Contains: Fibrinopeptide B]	FGB	0.0029
1629	Transcription factor AP-1	JUN	0.0029
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0029
319	Opioid receptor, sigma 1	OPRS1	0.0028
1435	Synaptic vesicle glycoprotein 2A	SV2A	0.0028
65	Matrix metalloproteinase-9	Not Available	0.0028
365	Dihydrofolate reductase	DHFR	0.0028
2381	Dihydrofolate reductase	DFR1	0.0028
2833	Dihydrofolate reductase	Not Available	0.0028
2931	Dihydrofolate reductase	folA	0.0028
3544	Dihydrofolate reductase	folA	0.0028
3682	Dihydrofolate reductase	folA	0.0028
6642	Dihydrofolate reductase	folA	0.0028
6756	Dihydrofolate reductase	dfrA	0.0028
6207	30S ribosomal protein S14	rpsN	0.0028
6209	30S ribosomal protein S19	rpsS	0.0028
6712	30S ribosomal protein S19	rpsS	0.0028
6726	30S ribosomal protein S19	rpsS	0.0028
1278	Pro-epidermal growth factor	EGF	0.0028
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0028
4103	Proteasome subunit beta type 2	PSMB2	0.0027
4102	Proteasome subunit beta type 5	PSMB5	0.0027
4101	Proteasome subunit beta type 1	PSMB1	0.0027
6232	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	GNAS	0.0027
6233	Adenylate cyclase type 2	ADCY2	0.0027
6234	Adenylate cyclase type 5	ADCY5	0.0027
751	Potassium channel subfamily K member 6	KCNK6	0.0027
4173	Tyrosine-protein kinase JAK2	JAK2	0.0027
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0027
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0027
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0027
340	Apoptotic protease-activating factor 1	APAF1	0.0027
1010	Cytochrome P450 51A1	CYP51A1	0.0027
889	3-oxoacyl-[acyl-carrier-protein] synthase 1	fabB	0.0027
6860	3-oxoacyl-[acyl-carrier-protein] synthase 1	kasA	0.0027
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0027
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0026
6824	Tyrosine-protein kinase Lyn	LYN	0.0026
6599	HTH-type transcriptional regulator ttgR	ttgR	0.0026
605	Fumarate reductase flavoprotein subunit	frdA	0.0026
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0026
3673	Fumarate reductase flavoprotein subunit	fccA	0.0026
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0026
6549	Fumarate reductase flavoprotein subunit	frdA	0.0026
1178	Adenosine A2a receptor	ADORA2A	0.0026
5997	Tumor necrosis factor ligand superfamily member 11	TNFSF11	0.0026
49	Endothelin B receptor	EDNRB	0.0026
427	Substance-P receptor	TACR1	0.0026
6220	Aryl hydrocarbon receptor	AHR	0.0026
1385	Angiotensin-converting enzyme 2	ACE2	0.0025
4252	Penicillin-binding protein 5	dacA	0.0025
5934	Cytochrome P450 26A1	CYP26A1	0.0025
5278	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1	PAPSS1	0.0025
229	Retinoic acid receptor beta	RARB	0.0025
172	Potassium channel subfamily K member 1	KCNK1	0.0025
162	Retinoic acid receptor gamma-1	RARG	0.0025
2091	Endoplasmin	HSP90B1	0.0025
3470	Hypothetical protein MG245 homolog	MPN_348	0.0025
6277	Heat shock cognate 71 kDa protein	HSPA8	0.0025
3426	Glutamine synthetase	glnA	0.0025
3987	Glutamine synthetase	GLUL	0.0025
3175	Glutamate--cysteine ligase	gshA	0.0025
5295	2-keto-3-deoxy-gluconate kinase	TT_P0036	0.0025
5189	Trimethylamine dehydrogenase	tmd	0.0025
2751	Holliday junction ATP-dependent DNA helicase ruvB	ruvB	0.0025
4755	Holliday junction ATP-dependent DNA helicase ruvB	ruvB	0.0025
4106	Guanylate kinase	GUK1	0.0025
4516	Guanylate kinase	gmk	0.0025
2511	MAP kinase-activated protein kinase 2	MAPKAPK2	0.0024
2270	Dephospho-CoA kinase	coaE	0.0024
4837	Cag-alfa	cag-alfa	0.0024
4774	NTPase P4	Not Available	0.0024
4838	PMS1 protein homolog 2	PMS2	0.0024
2284	Adenylate kinase	adk	0.0024
2296	Adenylate kinase	adk	0.0024
2311	Adenylate kinase	adk	0.0024
2312	Adenylate kinase	Not Available	0.0024
4839	DNA polymerase III subunit tau	dnaX	0.0024
730	Retinoic acid receptor alpha	RARA	0.0024
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0024
578	Endothelin-1 receptor	EDNRA	0.0024
3616	Fatty acid-binding protein, epidermal	FABP5	0.0024
5431	Lipid binding protein	Not Available	0.0024
5433	UPF0230 protein TM_1468	TM_1468	0.0024
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0024
5430	Hepatocyte nuclear factor 4-gamma	HNF4G	0.0024
544	Potassium voltage-gated channel subfamily E member 1	KCNE1	0.0024
1483	Membrane copper amine oxidase	AOC3	0.0024
159	Penicillin-binding protein 2B	penA	0.0024
6121	Penicillin-binding protein 2B	penA	0.0024
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0024
1992	Vitamin D-binding protein	GC	0.0024
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0024
6231	Pepsin A	PGA3	0.0024
5852	Type-2 angiotensin II receptor	AGTR2	0.0024
165	FL cytokine receptor	FLT3	0.0024
6459	Glycodelin	PAEP	0.0024
5432	Trafficking protein particle complex subunit 3	TRAPPC3	0.0024
1770	Phospholipase C	PLCL1	0.0024
2841	Phospholipase C	plc	0.0024
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0024
642	3-oxo-5-alpha-steroid 4-dehydrogenase 2	SRD5A2	0.0023
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0023
275	Arachidonate 5-lipoxygenase	ALOX5	0.0023
4221	Vascular endothelial growth factor	VEGF	0.0023
5816	Cadherin-5	CDH5	0.0023
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0023
332	Beta-lactamase	blaZ	0.0023
2478	Beta-lactamase	ampC	0.0023
2613	Beta-lactamase	ampC	0.0023
2635	Beta-lactamase	ampC	0.0023
2700	Beta-lactamase	penP	0.0023
5445	Beta-lactamase	blaB	0.0023
6019	Beta-lactamase	SHV-7	0.0023
6701	Beta-lactamase	cphA	0.0023
2683	Mono-ADP-ribosyltransferase C3	C3	0.0023
6501	Fatty acid-binding protein, liver	FABP1	0.0023
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0023
2599	Tyrosine-protein kinase HCK	HCK	0.0022
5271	Focal adhesion kinase 1	PTK2	0.0022
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0022
2390	Nonsecretory ribonuclease	RNASE2	0.0022
4217	Telomerase reverse transcriptase	TERT	0.0022
2922	Glycerol kinase	glpK	0.0022
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.0022
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0022
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0021
298	Renin	REN	0.0021
6506	Stathmin-4	STMN4	0.0021
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0021
2282	Protein recA	recA	0.0021
2315	Protein recA	recA	0.0021
2332	Protein recA	recA	0.0021
5263	Protein recA	recA	0.0021
408	Riboflavin kinase	RFK	0.0021
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0021
6857	[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial	PDK2	0.0021
331	Retinol-binding protein I, cellular	RBP1	0.0021
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.0021
4366	Riboflavin kinase/FMN adenylyltransferase	TM_0857	0.0021
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0021
4203	Histamine N-methyltransferase	HNMT	0.002
3669	Ribokinase	rbsK	0.002
6151	Monocarboxylate transporter 10	SLC16A10	0.002
283	SEC14-like protein 2	SEC14L2	0.002
3856	Fibroblast growth factor receptor 3	FGFR3	0.002
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.002
6755	Poliovirus receptor	PVR	0.002
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.002
788	Creatine kinase M-type	CKM	0.002
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.002
6390	Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	ATP2A1	0.002
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0019
461	Glycine receptor subunit alpha-3	GLRA3	0.0019
5294	Nucleoside diphosphate kinase A	NME1	0.0019
54	Prothrombin	F2	0.0019
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0019
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0019
2334	Dethiobiotin synthetase	bioD	0.0019
6555	Dethiobiotin synthetase	bioD	0.0019
2697	Uridine-cytidine kinase 2	UCK2	0.0019
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.0019
6167	Organic solute transporter subunit beta	OSTB	0.0019
6166	Organic solute transporter subunit alpha	OSTA	0.0019
6033	High affinity interleukin-8 receptor A	CXCR1	0.0018
453	S-adenosylmethionine synthetase isoform type-1	MAT1A	0.0018
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0018
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0018
2112	Toll-like receptor 9	TLR9	0.0018
5998	Toll-like receptor 8	TLR8	0.0018
61	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK	0.0018
2644	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK	0.0018
2710	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK	0.0018
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0018
469	Annexin A1	ANXA1	0.0018
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0018
712	Tubulin alpha chain	TUB1	0.0018
1968	ATP-sensitive inward rectifier potassium channel 12	KCNJ12	0.0018
5923	Microtubule-associated protein tau	MAPT	0.0018
5924	Microtubule-associated protein 4	MAP4	0.0018
565	Extracellular calcium-sensing receptor	CASR	0.0018
48	Pyridoxal kinase	PDXK	0.0018
201	Glutamate dehydrogenase 1, mitochondrial	GLUD1	0.0018
3312	Fatty acid-binding protein, brain	FABP7	0.0018
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0018
4122	Histone deacetylase 2	HDAC2	0.0018
1198	Serum paraoxonase/arylesterase 1	PON1	0.0018
6223	Penicillin-binding protein 1C	pbpC	0.0018
2320	Thymidine kinase, cytosolic	TK1	0.0018
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0017
613	Atrial natriuretic peptide receptor A	NPR1	0.0017
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0017
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0017
16	Adenosine A1 receptor	ADORA1	0.0017
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0017
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0017
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0017
2317	UDP-N-acetylmuramoylalanine--D-glutamate ligase	murD	0.0017
131	Synaptic vesicular amine transporter	SLC18A2	0.0017
6395	Myosin-14	MYH14	0.0017
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0017
144	Hemoglobin subunit alpha	HBA1	0.0017
106	Cannabinoid receptor 2	CNR2	0.0016
1422	Serine/threonine-protein kinase 6	AURKA	0.0016
6174	50S ribosomal protein L32	rpmF	0.0016
33	Cystine/glutamate transporter	SLC7A11	0.0016
3379	Kinesin-like protein KIF11	KIF11	0.0016
6766	O-GlcNAcase BT_4395	BT_4395	0.0016
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0016
3456	Heat shock protein HSP 90-beta	HSP90AB1	0.0016
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0016
173	Toll-like receptor 7	TLR7	0.0016
2297	Genome polyprotein	Not Available	0.0016
2322	Genome polyprotein	Not Available	0.0016
2694	Genome polyprotein	Not Available	0.0016
2719	Genome polyprotein	Not Available	0.0016
2860	Genome polyprotein	Not Available	0.0016
2928	Genome polyprotein	Not Available	0.0016
3160	Genome polyprotein	Not Available	0.0016
3260	Genome polyprotein	Not Available	0.0016
4783	Genome polyprotein	Not Available	0.0016
5726	Genome polyprotein	Not Available	0.0016
5779	Genome polyprotein	Not Available	0.0016
5867	Genome polyprotein	Not Available	0.0016
6253	Genome polyprotein	Not Available	0.0016
6301	Genome polyprotein	Not Available	0.0016
6380	Genome polyprotein	Not Available	0.0016
6381	Genome polyprotein	Not Available	0.0016
6437	Genome polyprotein	Not Available	0.0016
6520	Genome polyprotein	Not Available	0.0016
6521	Genome polyprotein	Not Available	0.0016
6652	Genome polyprotein	Not Available	0.0016
6734	Genome polyprotein	Not Available	0.0016
6735	Genome polyprotein	Not Available	0.0016
6736	Genome polyprotein	Not Available	0.0016
6737	Genome polyprotein	Not Available	0.0016
6738	Genome polyprotein	Not Available	0.0016
6739	Genome polyprotein	Not Available	0.0016
6744	Genome polyprotein	Not Available	0.0016
6748	Genome polyprotein	Not Available	0.0016
6894	Genome polyprotein	Not Available	0.0016
6898	Genome polyprotein	Not Available	0.0016
3233	Bile acid receptor	NR1H4	0.0015
6218	Pannexin-1	PANX1	0.0015
3809	Estrogen-related receptor gamma	ESRRG	0.0015
3611	Cytidine deaminase	cdd	0.0015
3707	Cytidine deaminase	cdd	0.0015
4211	Cytidine deaminase	CDA	0.0015
509	Thymidine kinase	TK	0.0015
570	Thymidine kinase	TK	0.0015
2559	Thymidine kinase	TK	0.0015
3430	Thymidine kinase	tdk	0.0015
3518	Thymidine kinase	TK	0.0015
5301	Thymidine kinase	tdk	0.0015
5771	Thymidine kinase	ORF36	0.0015
7009	Thymidine kinase	ORF36	0.0015
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0015
581	Cytochrome P450 2R1	CYP2R1	0.0015
1569	G1/S-specific cyclin-D1	CCND1	0.0015
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0014
1541	Metalloproteinase	mmp20	0.0014
3937	Fatty-acid amide hydrolase	FAAH	0.0014
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0014
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0014
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0014
1760	Aminopeptidase N	ANPEP	0.0014
6843	Aminopeptidase N	pepN	0.0014
2129	Sucrase-isomaltase, intestinal	SI	0.0014
489	Monocarboxylate transporter 2	SLC16A7	0.0014
1262	Corticotropin-lipotropin	POMC	0.0014
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.0014
117	Sterol O-acyltransferase 1	SOAT1	0.0014
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0014
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.0014
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0013
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0013
823	Fibroblast growth factor receptor 2	FGFR2	0.0013
5682	Ribonuclease pancreatic	RNASE1	0.0013
6211	Tubulin epsilon chain	TUBE1	0.0013
6212	Tubulin gamma-1 chain	TUBG1	0.0013
6210	Tubulin delta chain	TUBD1	0.0013
921	Glutamate receptor 2	GRIA2	0.0013
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0013
3810	Catechol O-methyltransferase	COMT	0.0013
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0013
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0013
7	Nitric oxide synthase, inducible	NOS2	0.0013
1405	Thiopurine S-methyltransferase	TPMT	0.0013
6116	Gastric triacylglycerol lipase	LIPF	0.0012
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0012
822	Aldose reductase	AKR1B1	0.0012
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0012
694	Matrix protein 2	M	0.0012
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0012
2240	Cell division protein kinase 2	CDK2	0.0012
3823	Cytokine receptor common gamma chain	IL2RG	0.0012
85	Growth hormone receptor	GHR	0.0012
6126	Carbonic anhydrase 7	CA7	0.0012
571	Melatonin receptor type 1A	MTNR1A	0.0012
362	Melatonin receptor type 1B	MTNR1B	0.0012
338	DNA polymerase	UL30	0.0012
379	DNA polymerase	UL54	0.0012
697	DNA polymerase	ORF28	0.0012
2482	DNA polymerase	43	0.0012
4104	DNA polymerase	BALF5	0.0012
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0012
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0012
1295	Fatty acid synthase	FASN	0.0012
4226	Uridine phosphorylase 2	UPP2	0.0012
3957	Adenosine deaminase	ADA	0.0012
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0012
6859	Protein S100-A4	S100A4	0.0012
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0012
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0011
1268	Neuropeptide S receptor	NPSR1	0.0011
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0011
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0011
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0011
6042	Prostaglandin reductase 2	PTGR2	0.0011
484	Tyrosine-protein kinase ABL2	ABL2	0.0011
754	Pancreatic triacylglycerol lipase	PNLIP	0.0011
4225	Uridine phosphorylase 1	UPP1	0.0011
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0011
5818	Folate receptor alpha	FOLR1	0.0011
2300	Lysozyme	E	0.0011
3633	Lysozyme	R	0.0011
5597	Lysozyme	17	0.0011
4311	tRNA	TRDMT1	0.0011
4325	tRNA	trmD	0.0011
4328	tRNA	trmD	0.0011
1630	Integrin beta-2	ITGB2	0.0011
896	Glutathione S-transferase Mu 1	GSTM1	0.0011
724	Interleukin-2 receptor alpha chain	IL2RA	0.0011
717	Interleukin-2 receptor subunit beta	IL2RB	0.0011
976	Platelet glycoprotein IX	GP9	0.0011
1374	Natriuretic peptides B	NPPB	0.001
1827	Gap junction alpha-1 protein	GJA1	0.001
1908	Vascular cell adhesion protein 1	VCAM1	0.001
1810	Protein S100-A1	S100A1	0.001
6097	Protein S100-A2	S100A2	0.001
908	Glutathione S-transferase theta-1	GSTT1	0.001
4116	Dihydropteroate synthetase	Not Available	0.001
4228	Keratin, type II cytoskeletal 7	KRT7	0.001
2461	D-alanyl-D-alanine carboxypeptidase	Not Available	0.001
5756	D-alanyl-D-alanine carboxypeptidase	dac	0.001
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.001
1063	Signal transducer and activator of transcription 5B	STAT5B	0.001
2216	Fibroblast growth factor receptor 4	FGFR4	0.001
413	Amidophosphoribosyltransferase	PPAT	0.001
2515	Amidophosphoribosyltransferase	purF	0.001
3714	Amidophosphoribosyltransferase	purF	0.001
6073	Potassium channel subfamily K member 9	KCNK9	0.001
6072	Potassium channel subfamily K member 3	KCNK3	0.001
1144	Hepatocyte growth factor receptor	MET	0.001
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.001
493	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	0.001
2404	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PIK3CG	0.001
512	DNA-directed RNA polymerase alpha chain	rpoA	0.001
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.001
4041	Microsomal glutathione S-transferase 2	MGST2	0.001
1176	Mitogen-activated protein kinase 1	MAPK1	0.001
2473	Tyrosine-protein kinase CSK	CSK	0.001
2398	Tyrosine-protein kinase ZAP-70	ZAP70	0.001
293	Gamma-glutamyl hydrolase	GGH	0.001
2268	Cholesterol oxidase	choB	0.0009
2822	Cholesterol oxidase	choA	0.0009
174	Sigma 1-type opioid receptor	SIGMAR1	0.0009
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0009
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0009
164	Histamine H4 receptor	HRH4	0.0009
6048	Troponin C, skeletal muscle	TNNC2	0.0009
6105	3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	0.0009
3086	Plasmepsin-2	Not Available	0.0009
6228	Nuclear receptor coactivator 1	NCOA1	0.0009
84	Nuclear receptor 0B1	NR0B1	0.0009
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.0009
1048	Protein S100-A13	S100A13	0.0009
2226	Protein S100-A12	S100A12	0.0009
1648	Elastin	ELN	0.0009
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0009
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0009
6131	Carbonic anhydrase 14	CA14	0.0009
2283	Steroid Delta-isomerase	ksi	0.0009
2920	Steroid Delta-isomerase	ksi	0.0009
153	Dopamine beta-hydroxylase	DBH	0.0009
1313	Lactoylglutathione lyase	GLO1	0.0009
992	Protein tyrosine kinase 2 beta	PTK2B	0.0009
6044	Serum paraoxonase/lactonase 3	PON3	0.0009
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0009
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0009
390	Adenosine A3 receptor	ADORA3	0.0009
6171	Solute carrier family 28 member 3	SLC28A3	0.0009
1650	Heme carrier protein 1	SLC46A1	0.0009
518	Peroxidase/catalase T	katG	0.0009
2132	Protein S100-B	S100B	0.0009
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0009
291	Nitric-oxide synthase, endothelial	NOS3	0.0009
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0008
3404	Exotoxin A	eta	0.0008
3639	Thymidine phosphorylase	deoA	0.0008
3936	Thymidine phosphorylase	TYMP	0.0008
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0008
22	30S ribosomal protein S4	rpsD	0.0008
6714	30S ribosomal protein S4	rpsD	0.0008
6122	Carbonic anhydrase 3	CA3	0.0008
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0008
94	5-hydroxytryptamine 4 receptor	HTR4	0.0008
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0008
572	Integrin alpha-L	ITGAL	0.0008
5798	Mitogen-activated protein kinase 11	MAPK11	0.0008
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0008
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0008
2298	Cytochrome P450-cam	camC	0.0008
2232	Interleukin-5	IL5	0.0008
1593	Mucin-2	MUC2	0.0008
4031	Glutathione S-transferase A1	GSTA1	0.0008
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.0008
1649	Small inducible cytokine A2	CCL2	0.0008
1025	Aquaporin-1	AQP1	0.0008
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0008
1275	Estrogen sulfotransferase	SULT1E1	0.0008
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0008
760	Fibroblast growth factor 1	FGF1	0.0007
473	L-lactate dehydrogenase A chain	LDHA	0.0007
6146	High affinity copper uptake protein 1	SLC31A1	0.0007
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0007
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0007
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0007
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0007
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0007
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0007
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0007
130	Prostacyclin synthase	PTGIS	0.0007
6316	ADP-ribosylation factor 1	ARF1	0.0007
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0007
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0007
2408	Tyrosine-protein kinase SYK	SYK	0.0007
3587	Gastrotropin	FABP6	0.0007
3221	Cytochrome c4	cc4	0.0007
2290	ADP-ribosyl cyclase 2	BST1	0.0007
226	Gonadotropin-releasing hormone receptor	GNRHR	0.0007
1830	5'-nucleotidase	NT5E	0.0007
6836	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	HIBCH	0.0007
6837	Serine/threonine-protein kinase 17B	STK17B	0.0007
444	Alcohol dehydrogenase 1B	ADH1B	0.0007
125	DNA polymerase beta	POLB	0.0007
1123	Eosinophil cationic protein	RNASE3	0.0007
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0006
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0006
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0006
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0006
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0006
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0006
6241	Nuclear receptor coactivator 2	NCOA2	0.0006
342	P protein [Includes: DNA-directed DNA polymerase	P	0.0006
612	P protein [Includes: DNA-directed DNA polymerase	P	0.0006
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0006
1196	Complement decay-accelerating factor	CD55	0.0006
677	Choline-phosphate cytidylyltransferase A	PCYT1A	0.0006
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0006
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0006
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0006
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0006
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0006
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0006
563	Thyroid peroxidase	TPO	0.0006
6656	UDP-glucuronosyltransferase 3A1	UGT3A1	0.0006
6168	Solute carrier family 22 member 16	SLC22A16	0.0006
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0006
634	Squalene monooxygenase	SQLE	0.0006
7196	Squalene monooxygenase	ERG1	0.0006
76	Nitric-oxide synthase, brain	NOS1	0.0005
5626	Nucleoside diphosphate kinase B	NME2	0.0005
2808	Chloramphenicol acetyltransferase 3	cat3	0.0005
1341	Histamine H3 receptor	HRH3	0.0005
3238	Multidrug resistance protein mexA	mexA	0.0005
3116	Bacterioferritin	bfr	0.0005
4906	Bacterioferritin	bfr	0.0005
4965	Bacterioferritin	bfr	0.0005
3173	Enolase	eno	0.0005
3709	Glycerol uptake facilitator protein	glpF	0.0005
3336	C4-dicarboxylate transport transcriptional regulatory protein dctD	dctD	0.0005
3393	TGF-beta receptor type-2	TGFBR2	0.0005
5489	Ribonucleoside-diphosphate reductase 1 subunit beta	nrdB	0.0005
6743	Non-fluorescent flavoprotein	luxF	0.0005
6753	Apolipoprotein M	APOM	0.0005
2528	Fatty acid metabolism regulator protein	fadR	0.0005
6740	Fatty acid metabolism regulator protein	fadR	0.0005
6752	Guanylyl cyclase-activating protein 1	GUCA1A	0.0005
394	Calcineurin subunit B isoform 1	PPP3R1	0.0005
6742	Recoverin	RCVRN	0.0005
6747	Chalcone/stilbene synthase family protein	MT1417	0.0005
6741	Peroxisomal 3,2-trans-enoyl-CoA isomerase	PECI	0.0005
6522	Hepatocyte nuclear factor 4-alpha	HNF4A	0.0005
6751	Gag polyprotein	gag	0.0005
6746	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	PPP3CA	0.0005
6749	Polyprotein	Not Available	0.0005
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0005
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0005
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0005
2417	Chloramphenicol acetyltransferase	cat	0.0005
3278	Chloramphenicol acetyltransferase	cat	0.0005
2810	Dr hemagglutinin structural subunit	draA	0.0005
517	Alcohol dehydrogenase 1C	ADH1C	0.0005
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0005
6344	ATP synthase subunit gamma, mitochondrial	ATP5C1	0.0005
6343	ATP synthase subunit beta, mitochondrial	ATP5B	0.0005
6342	ATP synthase subunit alpha, mitochondrial	ATP5A1	0.0005
3601	Dihydropteroate synthase 1	folP1	0.0005
3807	Dihydropteroate synthase 1	folP1	0.0005
3808	Dihydropteroate synthase 2	folP2	0.0005
5961	Insulin	INS	0.0005
6527	Lymphocyte antigen 96	LY96	0.0005
3913	Glutamic acid decarboxylase	GAD65	0.0005
3191	Histidinol dehydrogenase	hisD	0.0005
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0004
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0004
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0004
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0004
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0004
6259	(3R)-hydroxymyristoyl-acyl carrier protein dehydratase	fabZ	0.0004
6750	ADP-ribosylation factor 6	ARF6	0.0004
4692	A/G-specific adenine glycosylase	mutY	0.0004
6524	Protein tonB	tonB	0.0004
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0004
4943	Cytochrome c6	petJ	0.0004
4954	Soluble cytochrome b558	Not Available	0.0004
4942	Diheme cytochrome c napB	napB	0.0004
4916	Cyanoglobin	glbN	0.0004
4994	Hemoglobin-like protein HbO	glbO	0.0004
5000	HemO	hemO	0.0004
4981	Iron-starvation protein PigA	pigA	0.0004
4984	Neuroglobin	NGB	0.0004
4947	Bacterial hemoglobin	vhb	0.0004
4935	Cytochrome c-554	cycA1	0.0004
4975	Cytochrome c-556	RPA3973	0.0004
4936	Cytochrome c2 iso-2	Not Available	0.0004
4934	Cytochrome c-551	nirM	0.0004
5218	Cytochrome c-551	nirM	0.0004
4905	Cytochrome c2	Not Available	0.0004
4939	Cytochrome c2	cycA	0.0004
4964	Cytochrome c2	cycA	0.0004
4979	Cytochrome c2	cycA	0.0004
6673	Cytochrome c2	cycA	0.0004
4910	Cytoglobin	CYGB	0.0004
4915	Cytochrome c-550	psbV	0.0004
4959	Cytochrome c-550	psbV	0.0004
5216	Cytochrome c-550	psbV	0.0004
4925	Cytochrome c-type protein SHP	shp	0.0004
4961	Hemophore HasA	hasA	0.0004
4909	CooA protein	cooA	0.0004
4998	Hemoglobin-like protein yjbI	yjbI	0.0004
4904	Cytochrome c family protein	GSU1996	0.0004
4931	Cytochrome P450 167A1	CYP167A1	0.0004
644	Heme oxygenase 2	HMOX2	0.0004
4982	Heme oxygenase 2	pbsA2	0.0004
4937	Cytochrome oxidase subunit II	rcoxA	0.0004
4903	Methyl-accepting chemotaxis protein	Tar4	0.0004
4971	Nonaheme cytochrome c	hmcA	0.0004
4989	Cytochrome c551 peroxidase	ccp	0.0004
5222	Cytochrome c551 peroxidase	ccpA	0.0004
4976	Apocytochrome f	petA	0.0004
6407	Apocytochrome f	petA	0.0004
4907	Cytochrome c-L	moxG	0.0004
6865	Cytochrome c-L	moxG	0.0004
4972	P450cin	cinA	0.0004
4960	Putative cytochrome P450-family protein	SCO7417	0.0004
4764	Cytochrome P450 165C4	CYP165C4	0.0004
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0004
4999	Cytochrome P450 165B3	CYP165B3	0.0004
4952	Catalase/peroxidase	katA	0.0004
4993	Hydroxylamine oxidoreductase	hao1	0.0004
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0004
4922	Cytochrome c, putative	SO_4144	0.0004
3093	Catalase HPII	katE	0.0004
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0004
2435	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase	lpxC	0.0004
6613	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase	lpxC	0.0004
6163	Copper-transporting ATPase 2	ATP7B	0.0004
6165	Copper-transporting ATPase 1	ATP7A	0.0004
735	Alanine aminotransferase 1	GPT	0.0004
3904	Alanine aminotransferase 2	GPT2	0.0004
2802	Endoglucanase G	celCCG	0.0004
2391	Ferrochelatase	hemH	0.0004
6502	Ferrochelatase	DKFZp686P18130	0.0004
1591	Ferrochelatase, mitochondrial	FECH	0.0004
251	Alcohol dehydrogenase 1A	ADH1A	0.0004
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0004
719	Retinoic acid receptor responder protein 1	RARRES1	0.0003
770	Retinoic acid-induced protein 3	GPRC5A	0.0003
820	Glycine receptor subunit alpha-2	GLRA2	0.0003
864	Gag-Pol polyprotein	gag-pol	0.0003
2237	Gag-Pol polyprotein	gag-pol	0.0003
2326	Gag-Pol polyprotein	gag-pol	0.0003
2451	Gag-Pol polyprotein	gag-pol	0.0003
2901	Gag-Pol polyprotein	gag-pol	0.0003
3165	Gag-Pol polyprotein	gag-pol	0.0003
3722	Gag-Pol polyprotein	gag-pol	0.0003
6306	Gag-Pol polyprotein	gag-pol	0.0003
6624	Gag-Pol polyprotein	gag-pol	0.0003
2101	Glutathione-requiring prostaglandin D synthase	HPGDS	0.0003
268	Adenosine A2b receptor	ADORA2B	0.0003
828	Phenylalanine-4-hydroxylase	PAH	0.0003
3109	Phenylalanine-4-hydroxylase	phhA	0.0003
825	Arsenical pump-driving ATPase	ASNA1	0.0003
3435	Arsenical pump-driving ATPase	arsA	0.0003
486	Serine/threonine-protein kinase ALS2CR7	CDK15	0.0003
2105	ATP-binding cassette sub-family G member 1	ABCG1	0.0003
377	Beta-adrenergic receptor kinase 1	ADRBK1	0.0003
510	Serine/threonine-protein kinase receptor R3	ACVRL1	0.0003
733	Activin receptor type 1B	ACVR1B	0.0003
225	NEDD8-activating enzyme E1 regulatory subunit	NAE1	0.0003
745	Anti-Muellerian hormone type-2 receptor	AMHR2	0.0003
483	A-Raf proto-oncogene serine/threonine-protein kinase	ARAF	0.0003
21	Beta-adrenergic receptor kinase 2	ADRBK2	0.0003
154	AFG3-like protein 2	AFG3L2	0.0003
395	ALK tyrosine kinase receptor	Not Available	0.0003
6496	Cytochrome c oxidase subunit 8A, mitochondrial	COX8A	0.0003
6493	Cytochrome c oxidase subunit 6C	COX6C	0.0003
6495	Cytochrome c oxidase subunit 7C, mitochondrial	COX7C	0.0003
6499	Cytochrome c oxidase polypeptide 7A1, mitochondrial	COX7A1	0.0003
6494	Cytochrome c oxidase subunit 7B, mitochondrial	COX7B	0.0003
6491	Cytochrome c oxidase subunit 5A, mitochondrial	COX5A	0.0003
6498	Cytochrome c oxidase subunit 6B1	COX6B1	0.0003
6497	Cytochrome c oxidase subunit 6A2, mitochondrial	COX6A2	0.0003
6489	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	COX4I1	0.0003
5793	Cytochrome c oxidase subunit 2	MT-CO2	0.0003
6559	Cytochrome c oxidase subunit 2	ctaC	0.0003
6669	Cytochrome c oxidase subunit 2	ctaC	0.0003
6490	Cytochrome c oxidase subunit 3	MT-CO3	0.0003
371	Cytochrome c oxidase subunit 1	MT-CO1	0.0003
6558	Cytochrome c oxidase subunit 1	ctaD	0.0003
292	Activin receptor type-1	ACVR1	0.0003
849	Activated CDC42 kinase 1	TNK2	0.0003
569	Retinal dehydrogenase 2	ALDH1A2	0.0003
267	Plasminogen activator inhibitor 1	SERPINE1	0.0003
4920	Peroxidase/catalase	katG	0.0003
2540	Choloylglycine hydrolase	cbh	0.0003
4948	Cytochrome c-553	Not Available	0.0003
4923	Cytochrome c3	DvMF_2499	0.0003
4945	Cytochrome c3	Not Available	0.0003
4949	Cytochrome c3	DVU_3171	0.0003
4968	Cytochrome c3	cytc3	0.0003
4997	Cytochrome c3	SO_2727	0.0003
5219	Cytochrome c3	cyd	0.0003
2119	Cytochrome b5	CYB5A	0.0003
4902	Nine-heme cytochrome c	Ddes_2038	0.0003
3189	High-molecular-weight cytochrome c	hmcA	0.0003
4990	PpcA	ppcA	0.0003
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0003
2427	Ferrichrome-iron receptor	fhuA	0.0003
3375	Acidic cytochrome c3	Not Available	0.0003
4988	Sulfite oxidase, mitochondrial	SUOX	0.0003
4037	Hypothetical protein	GPX1	0.0003
4297	Hypothetical protein	SP_1951	0.0003
4521	Hypothetical protein	BC_2969	0.0003
4540	Hypothetical protein	TM_1070	0.0003
4555	Hypothetical protein	MT1739	0.0003
4569	Hypothetical protein	mshD	0.0003
4578	Hypothetical protein	PA3270	0.0003
4747	Hypothetical protein	PA3967	0.0003
5177	Hypothetical protein	TM_0096	0.0003
5194	Hypothetical protein	PA1204	0.0003
5240	Hypothetical protein	Rv2991	0.0003
5370	Hypothetical protein	TM_1158	0.0003
5710	Hypothetical protein	Tb927.5.1360	0.0003
3570	Cytochrome P450 152A1	cypC	0.0003
2915	Sensor protein fixL	fixL	0.0003
4944	Sensor protein fixL	fixL	0.0003
4289	Cytochrome P450	TT_P0059	0.0003
6262	Cytochrome P450	staP	0.0003
4813	Heme oxygenase	hmuO	0.0003
5769	Heme oxygenase	Not Available	0.0003
4992	Cytochrome c peroxidase	Not Available	0.0003
4385	Cytochrome c'	Not Available	0.0003
4967	Cytochrome c'	cycA	0.0003
5038	Cytochrome c'	Not Available	0.0003
5223	Cytochrome c'	cycP	0.0003
704	Long-chain-fatty-acid--CoA ligase 1	ACSL1	0.0003
821	Acetyl-coenzyme A synthetase 2-like, mitochondrial	ACSS1	0.0003
386	Acetyl-coenzyme A synthetase, cytoplasmic	ACSS2	0.0003
297	Adenylate cyclase type 1	ADCY1	0.0003
289	Cytosolic purine 5'-nucleotidase	NT5C2	0.0003
611	Retinal dehydrogenase 1	ALDH1A1	0.0003
2230	Catalase	CAT	0.0003
3249	Catalase	katA	0.0003
3625	Catalase	katA	0.0003
4539	Catalase	katA	0.0003
4941	Catalase	katB	0.0003
6264	cAMP-dependent protein kinase inhibitor alpha	PKIA	0.0003
6221	Steroid hormone receptor ERR1	ESRRA	0.0003
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.0003
1039	Histone deacetylase 9	HDAC9	0.0003
3670	Soluble cytochrome b562 precursor	cybC	0.0003
3411	Cytochrome P450 121	cyp121	0.0003
3291	Cytochrome c-552	cycA	0.0003
4927	Cytochrome c-552	nrfA	0.0003
4938	Cytochrome c-552	cycA	0.0003
4953	Cytochrome c-552	nrfA	0.0003
5217	Cytochrome c-552	cycM	0.0003
2617	Nitric oxide synthase oxygenase	nos	0.0003
2701	Nitric oxide synthase oxygenase	nos	0.0003
3102	Flavohemoprotein	hmp	0.0003
4969	Flavohemoprotein	hmp	0.0003
4386	Hemoglobin-like protein HbN	glbN	0.0003
740	Argininosuccinate synthase	ASS1	0.0002
865	Argininosuccinate synthase	ASS1	0.0002
2680	Argininosuccinate synthase	argG	0.0002
3194	Argininosuccinate synthase	argG	0.0002
661	ADP/ATP translocase 1	SLC25A4	0.0002
6021	Adenosine kinase	ADK	0.0002
242	Asparagine synthetase [glutamine-hydrolyzing]	ASNS	0.0002
6500	Phospholipase A2	PLA2G1B	0.0002
3127	Nitrite reductase	nirS	0.0002
3284	Nitrite reductase	nirS	0.0002
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0002
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0002
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0002
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0002
6135	Sodium channel subunit beta-4	SCN4B	0.0002
6134	Sodium channel subunit beta-3	SCN3B	0.0002
6132	Sodium channel subunit beta-1	SCN1B	0.0002
6127	Carbonic anhydrase-related protein	CA8	0.0002
6128	Carbonic anhydrase-related protein 10	CA10	0.0002
6133	Sodium channel subunit beta-2	SCN2B	0.0002
6129	Carbonic anhydrase-related protein 11	CA11	0.0002
4608	Putative cytochrome P450	SCO1207	0.0002
4963	Putative cytochrome P450	SCO2884	0.0002
6254	Putative cytochrome P450	SCO6998	0.0002
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0002
6130	Carbonic anhydrase 13	CA13	0.0002
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0002
358	Cystathionine beta-synthase	CBS	0.0002
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0002
1507	Cytochrome c	CYCS	0.0002
693	Hemoglobin subunit beta	HBB	0.0002
6268	Hydroxyacid oxidase 1	HAO1	0.0002
810	Heme oxygenase 1	HMOX1	0.0002
3391	Heme oxygenase 1	pbsA1	0.0002
3007	Carbonic anhydrase 12	CA12	0.0002
4205	Carbonic anhydrase 9	CA9	0.0002

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB08820 - Ivacaftor

Targets

Enzymes

Transporters

Carriers

Predictions