DT-Web: DB08828

Identification

Name

Vismodegib

Accession Number

DB08828

Type

small molecule

Description

Vismodegib inhibits the hedgehog signalling pathway and is indicated for treatment of adult basal cell carcinoma. FDA approved on Jan 30, 2012.

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Antineoplastic Agents

Molecular Weight

421.297

Groups

approved

Monoisotopic Weight

420.010218428

Pharmacology

Indication

Vismodegib is used for treating locally advanced or metastatic basal cell carcinoma in patients whose carcinoma has recurred after surgery, and in patients who are not candidates for surgery or radiation.

Mechanism of action

Mutations of the Hedgehog pathway may results in uncontrolled proliferation of skin basal cells. Vismodegib binds to and inhibits the transmembrane protein Smoothened homologue (SMO) to inhibit the Hedgehog signalling pathway.

Absorption

The absolute bioavailability of a single dose is 31.8%. Absorption is saturable and is not affected by food.

Protein binding

Vismodegib is highly protein bound with plasma protein binding at about 99%. Vismodegib binds to the plasma proteins, albumin and alpha-1-acid glycoprotein (saturable bnding).

Biotransformation

The main metabolic enzymes are CYP2C9 and CYP3A4, however more than 98% of total systemic vismodegib is not metabolized. Metabolic pathways of vismodegib in humans include oxidation, glucuronidation, and pyridine ring cleavage. The two most abundant oxidative metabolites recovered in feces are produced in vitro by recombinant CYP2C9 and CYP3A4/5.

Route of elimination

Vismodegib is mostly excreted unchanged, and the main route of elimination is by the feces (82%) and the urine accounts for 4.4%.

Toxicity

Increased risk of embryo-fetal death and significant birth defects. Common adverse event include muscle spasms, alopecia, dysgeusia, weight loss, fatigue, nausea, diarrhea, decreased appetite, constipation, arthralgias, vomiting, and ageusia.

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Azithromycin	P-glycoprotein inhibitors may increase the chance of adverse drug reactions.
Clarithromycin	P-glycoprotein inhibitors may increase the chance of adverse drug reactions.
Erythromycin	P-glycoprotein inhibitors may increase the chance of adverse drug reactions.
Ivacaftor	P-glycoprotein inhibitors may increase the chance of adverse drug reactions. Consider using alternative therapy.
Omeprazole	Vismodegib serum concentrations may be decreased by proton pump inhibitors such as omeprazole.
Ranitidine	Vismodegib serum concentrations may be decreased by histamine 2 receptor antagonists such as ranitidine.

Food Interactions

Food does not affect absorption.

Smoothened homolog
Name	Smoothened homolog
Gene Name	SMO
Pharmacological action	yes
Actions	antagonist
References	Stated on FDA label. - Sandhiya S, Melvin G, Kumar SS, Dkhar SA: The dawn of hedgehog inhibitors: Vismodegib. J Pharmacol Pharmacother. 2013 Jan;4(1):4-7. doi: 10.4103/0976-500X.107628. - Pubmed
DTHybrid score	Not Available

Cytochrome P450 2C9
Name	Cytochrome P450 2C9
Gene Name	CYP2C9
Actions	substrate,inhibitor
References	Stated on FDA label. - Sandhiya S, Melvin G, Kumar SS, Dkhar SA: The dawn of hedgehog inhibitors: Vismodegib. J Pharmacol Pharmacother. 2013 Jan;4(1):4-7. doi: 10.4103/0976-500X.107628. - Pubmed
DTHybrid score	0.5034
Cytochrome P450 3A4
Name	Cytochrome P450 3A4
Gene Name	CYP3A4
Actions	substrate
References	Stated on FDA label. - Sandhiya S, Melvin G, Kumar SS, Dkhar SA: The dawn of hedgehog inhibitors: Vismodegib. J Pharmacol Pharmacother. 2013 Jan;4(1):4-7. doi: 10.4103/0976-500X.107628. - Pubmed
DTHybrid score	0.6471
Cytochrome P450 2C8
Name	Cytochrome P450 2C8
Gene Name	CYP2C8
Actions	inhibitor
References	FDA label -
DTHybrid score	0.3709
Cytochrome P450 2C19
Name	Cytochrome P450 2C19
Gene Name	CYP2C19
Actions	inhibitor
References	FDA label -
DTHybrid score	0.4207

Multidrug resistance protein 1
Name	Multidrug resistance protein 1
Gene Name	ABCB1
Actions	substrate
References	Sandhiya S, Melvin G, Kumar SS, Dkhar SA: The dawn of hedgehog inhibitors: Vismodegib. J Pharmacol Pharmacother. 2013 Jan;4(1):4-7. doi: 10.4103/0976-500X.107628. - Pubmed
DTHybrid score	0.4753
ATP-binding cassette sub-family G member 2
Name	ATP-binding cassette sub-family G member 2
Gene Name	ABCG2
Actions	inhibitor
References	FDA Label -
DTHybrid score	0.2656

Multidrug resistance protein 1
Name	Multidrug resistance protein 1
Gene Name	ABCB1
Actions
References	Not Available
DTHybrid score	0.4753
ATP-binding cassette sub-family G member 2
Name	ATP-binding cassette sub-family G member 2
Gene Name	ABCG2
Actions
References	Not Available
DTHybrid score	0.2656

Id	Partner name	Gene Name	Score
4119	Cytochrome P450 2D6	CYP2D6	0.3148
4200	Cytochrome P450 1A2	CYP1A2	0.2543
4118	Cytochrome P450 3A5	CYP3A5	0.2301
6030	Cytochrome P450 2B6	CYP2B6	0.1689
6107	Cytochrome P450 3A7	CYP3A7	0.1536
6013	Cytochrome P450 2E1	CYP2E1	0.1372
20	Prostaglandin G/H synthase 1	PTGS1	0.1142
6024	Cytochrome P450 1A1	CYP1A1	0.1075
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.0949
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.0943
862	Multidrug resistance-associated protein 1	ABCC1	0.0904
5718	Cytochrome P450 2A6	CYP2A6	0.0897
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.0828
1729	Solute carrier family 22 member 6	SLC22A6	0.0771
290	Prostaglandin G/H synthase 2	PTGS2	0.0692
6106	Cytochrome P450 2C18	CYP2C18	0.0664
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0623
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0588
6145	Solute carrier family 22 member 1	SLC22A1	0.0565
824	Sodium-dependent serotonin transporter	SLC6A4	0.0563
492	Histamine H1 receptor	HRH1	0.0544
556	Alpha-1A adrenergic receptor	ADRA1A	0.0542
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.0541
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0515
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0508
1898	Cytochrome P450 1B1	CYP1B1	0.0504
6142	Solute carrier family 22 member 8	SLC22A8	0.0495
6144	Solute carrier family 22 member 2	SLC22A2	0.0474
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0473
2164	Multidrug resistance-associated protein 4	ABCC4	0.0468
776	Bile salt export pump	ABCB11	0.0447
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0433
3811	Cytochrome P450 19A1	CYP19A1	0.0433
844	Epidermal growth factor receptor	EGFR	0.0422
136	Estrogen receptor	ESR1	0.0411
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0399
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0397
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0393
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.038
831	D(2) dopamine receptor	DRD2	0.0376
891	Dihydropteroate synthase	folP	0.037
5359	Dihydropteroate synthase	folP	0.037
7175	Dihydropteroate synthase	sulI	0.037
6143	Solute carrier family 22 member 7	SLC22A7	0.0369
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0365
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0364
632	Alpha-1B adrenergic receptor	ADRA1B	0.0363
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0361
871	Glucocorticoid receptor	NR3C1	0.0359
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0346
731	HIV-1 protease	HIV-1 protease	0.0344
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0343
1024	Solute carrier family 22 member 11	SLC22A11	0.0341
789	Alpha-1D adrenergic receptor	ADRA1D	0.0326
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0325
766	Beta-2 adrenergic receptor	ADRB2	0.0319
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0319
847	Mu-type opioid receptor	OPRM1	0.0296
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0292
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0286
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0284
193	Beta-1 adrenergic receptor	ADRB1	0.0283
23	D(1A) dopamine receptor	DRD1	0.0282
118	Organic cation/carnitine transporter 2	SLC22A5	0.0278
713	Sodium-dependent dopamine transporter	SLC6A3	0.0276
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0274
318	Alpha-2A adrenergic receptor	ADRA2A	0.0274
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0272
260	Cytochrome P450 51	ERG11	0.0263
761	Cytochrome P450 51	ERG11	0.0263
3163	Cytochrome P450 51	cyp51	0.0263
696	Kappa-type opioid receptor	OPRK1	0.0263
6147	Solute carrier family 22 member 3	SLC22A3	0.0262
3941	Amine oxidase [flavin-containing] A	MAOA	0.026
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0259
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0251
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0251
817	DNA topoisomerase 2-alpha	TOP2A	0.0249
70	Type-1 angiotensin II receptor	AGTR1	0.0244
6137	Multidrug resistance-associated protein 6	ABCC6	0.0244
504	Mast/stem cell growth factor receptor	KIT	0.0244
467	Delta-type opioid receptor	OPRD1	0.0243
6141	Sodium/bile acid cotransporter	SLC10A1	0.0241
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0241
465	Calmodulin	CALM1	0.024
122	P2Y purinoceptor 12	P2RY12	0.0234
590	5-hydroxytryptamine 2C receptor	HTR2C	0.023
3923	Cholinesterase	BCHE	0.0229
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0225
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0224
468	Cytochrome P450 4A11	CYP4A11	0.022
6148	Multidrug resistance-associated protein 7	ABCC10	0.022
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.022
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0213
6182	Cytochrome P450 2J2	CYP2J2	0.0212
146	Androgen receptor	AR	0.0211
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0211
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0211
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.021
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.021
1353	DNA topoisomerase 1	TOP1	0.0207
3552	DNA topoisomerase 1	topA	0.0207
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0206
4604	Liver carboxylesterase 1	CES1	0.0201
3939	Amine oxidase [flavin-containing] B	MAOB	0.02
756	Sex hormone-binding globulin	SHBG	0.0197
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0196
6031	Cytochrome P450 3A43	CYP3A43	0.0192
380	Cytochrome P450 17A1	CYP17A1	0.0185
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0183
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0182
183	Vascular endothelial growth factor A	VEGFA	0.0181
885	5-hydroxytryptamine 1B receptor	HTR1B	0.018
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0179
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0178
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0178
869	Estrogen receptor beta	ESR2	0.0176
4120	NADPH--cytochrome P450 reductase	POR	0.0175
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.017
1389	Transforming growth factor beta-1	TGFB1	0.0169
6136	Multidrug resistance-associated protein 5	ABCC5	0.0169
614	Progesterone receptor	PGR	0.0166
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0166
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0164
833	Organic cation/carnitine transporter 1	SLC22A4	0.0163
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0162
407	Vascular endothelial growth factor receptor 2	KDR	0.0161
373	Transthyretin	TTR	0.0161
738	Monocarboxylate transporter 1	SLC16A1	0.016
5787	Angiopoietin-1 receptor	TEK	0.0156
29	Tubulin beta-1 chain	TUBB1	0.0156
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0155
1757	Myeloperoxidase	MPO	0.0154
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0153
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0151
424	Dihydroorotate dehydrogenase, mitochondrial	DHODH	0.0151
26	Vascular endothelial growth factor receptor 3	FLT4	0.0151
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0149
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0148
811	Translocator protein	TSPO	0.0147
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0146
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0146
32	Vascular endothelial growth factor receptor 1	FLT1	0.0144
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0144
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0143
6085	Fatty acid-binding protein, intestinal	FABP2	0.0143
6541	Peptostreptococcal albumin-binding protein	pab	0.0142
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0141
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0139
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0139
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0137
629	Alpha-2B adrenergic receptor	ADRA2B	0.0132
124	Histamine H2 receptor	HRH2	0.0131
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.0131
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0128
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0128
6102	Arylamine N-acetyltransferase 2	NAT2	0.0128
638	D(3) dopamine receptor	DRD3	0.0128
161	Tubulin beta chain	TUBB	0.0128
312	Tubulin beta chain	TUB2	0.0128
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0127
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0127
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0127
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0124
1517	Beta-3 adrenergic receptor	ADRB3	0.0123
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0123
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0122
1656	CYP2B protein	CYP2B	0.0122
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0122
1050	Bile salt sulfotransferase	SULT2A1	0.0121
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0121
1618	High affinity nerve growth factor receptor	NTRK1	0.012
2539	Tubulin alpha-1 chain	TUBA4A	0.0118
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0117
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0115
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0114
2211	Fatty acid-binding protein, heart	FABP3	0.0114
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0114
33	Cystine/glutamate transporter	SLC7A11	0.0113
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.011
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.011
6220	Aryl hydrocarbon receptor	AHR	0.011
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.011
365	Dihydrofolate reductase	DHFR	0.0109
2381	Dihydrofolate reductase	DFR1	0.0109
2833	Dihydrofolate reductase	Not Available	0.0109
2931	Dihydrofolate reductase	folA	0.0109
3544	Dihydrofolate reductase	folA	0.0109
3682	Dihydrofolate reductase	folA	0.0109
6642	Dihydrofolate reductase	folA	0.0109
6756	Dihydrofolate reductase	dfrA	0.0109
777	Tumor necrosis factor	TNF	0.0109
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0109
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0109
378	Alpha-2C adrenergic receptor	ADRA2C	0.0108
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0108
952	Dipeptidyl peptidase 4	DPP4	0.0107
6599	HTH-type transcriptional regulator ttgR	ttgR	0.0105
768	FK506-binding protein 1A	FKBP1A	0.0105
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0105
117	Sterol O-acyltransferase 1	SOAT1	0.0104
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0104
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0104
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0104
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0104
4773	Deoxycytidine kinase	DCK	0.0104
24	Thymidylate synthase	TMP1	0.0103
359	Thymidylate synthase	TYMS	0.0103
2626	Thymidylate synthase	thyA	0.0103
2729	Thymidylate synthase	thyA	0.0103
5352	Thymidylate synthase	THYA	0.0103
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0103
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0103
482	Glycine receptor subunit alpha-1	GLRA1	0.0103
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0103
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0101
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0098
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0098
818	50S ribosomal protein L10	rplJ	0.0098
4116	Dihydropteroate synthetase	Not Available	0.0097
1192	Sulfotransferase 1A1	SULT1A1	0.0097
49	Endothelin B receptor	EDNRB	0.0096
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0096
558	Solute carrier family 12 member 1	SLC12A1	0.0094
566	Serotransferrin	TF	0.0094
68	Cannabinoid receptor 1	CNR1	0.0094
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0093
3810	Catechol O-methyltransferase	COMT	0.0093
992	Protein tyrosine kinase 2 beta	PTK2B	0.0092
705	Glutamate receptor 1	GRIA1	0.0091
232	Corticosteroid-binding globulin	SERPINA6	0.0091
716	5-hydroxytryptamine 7 receptor	HTR7	0.0091
904	Glutathione S-transferase P	GSTP1	0.009
578	Endothelin-1 receptor	EDNRA	0.009
592	Carbonic anhydrase 4	CA4	0.009
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0088
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0088
275	Arachidonate 5-lipoxygenase	ALOX5	0.0087
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0087
3947	Xanthine dehydrogenase/oxidase	XDH	0.0087
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0086
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0086
737	Mineralocorticoid receptor	NR3C2	0.0086
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0085
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0085
165	FL cytokine receptor	FLT3	0.0085
6014	Cytochrome P450 2A13	CYP2A13	0.0084
474	Acetylcholinesterase	ACHE	0.0084
427	Substance-P receptor	TACR1	0.0084
244	Angiotensin-converting enzyme	ACE	0.0084
432	D(4) dopamine receptor	DRD4	0.0084
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0083
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0083
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0083
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0083
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0082
295	Carbonic anhydrase 1	CA1	0.0081
1852	Microtubule-associated protein 2	MAP2	0.0081
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0081
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0081
88	Retinoic acid receptor RXR-beta	RXRB	0.008
6525	Group IID secretory phospholipase A2	PLA2G2D	0.008
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.008
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0079
6432	Transporter	snf	0.0079
1010	Cytochrome P450 51A1	CYP51A1	0.0079
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0079
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0079
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0078
645	Penicillin-binding protein 1A	mrcA	0.0078
5805	Penicillin-binding protein 1A	ponA	0.0078
6185	Penicillin-binding protein 1A	mrcA	0.0078
6799	Penicillin-binding protein 1A	pbpA	0.0078
442	Envelope glycoprotein	gp41	0.0078
4859	Envelope glycoprotein	env	0.0078
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0078
273	Apoptosis regulator Bcl-2	BCL2	0.0077
357	Carbonic anhydrase 2	CA2	0.0077
823	Fibroblast growth factor receptor 2	FGFR2	0.0076
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0075
603	DNA polymerase alpha catalytic subunit	POLA1	0.0074
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0074
1541	Metalloproteinase	mmp20	0.0074
6146	High affinity copper uptake protein 1	SLC31A1	0.0074
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0074
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0073
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0073
543	Penicillin-binding protein 1B	mrcB	0.0072
6186	Penicillin-binding protein 1B	ponB	0.0072
6822	Penicillin-binding protein 1b	pbp1b	0.0072
6844	Penicillin-binding protein 1b	pbp1b	0.0072
469	Annexin A1	ANXA1	0.0072
1	Peptidoglycan synthetase ftsI	ftsI	0.0071
4155	Peptidoglycan synthetase ftsI	ftsI	0.0071
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0071
3856	Fibroblast growth factor receptor 3	FGFR3	0.0071
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0071
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0071
6149	Solute carrier family 22 member 10	SLC22A10	0.0071
5300	Antigen peptide transporter 1	TAP1	0.0071
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0071
571	Melatonin receptor type 1A	MTNR1A	0.007
362	Melatonin receptor type 1B	MTNR1B	0.007
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.007
239	Coagulation factor X	F10	0.007
3932	Glutathione S-transferase A2	GSTA2	0.007
459	Retinoic acid receptor RXR-alpha	RXRA	0.007
594	Thyroxine-binding globulin	SERPINA7	0.007
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.007
908	Glutathione S-transferase theta-1	GSTT1	0.0069
2853	14 kDa fatty acid-binding protein	Not Available	0.0068
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.0068
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0068
106	Cannabinoid receptor 2	CNR2	0.0068
6138	Multidrug resistance protein 3	ABCB4	0.0067
6043	Putative G-protein coupled receptor 44	GPR44	0.0067
36	Insulin receptor	INSR	0.0066
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0066
921	Glutamate receptor 2	GRIA2	0.0065
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0065
758	Thyroid hormone receptor alpha	THRA	0.0064
1864	RET proto-oncogene	RET	0.0064
780	Retinoic acid receptor RXR-gamma	RXRG	0.0064
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0064
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0064
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0064
6020	Aldehyde oxidase	AOX1	0.0063
3432	Multidrug-efflux transporter 1 regulator	bmrR	0.0063
4476	Mannitol dehydrogenase	mtlD	0.0063
4217	Telomerase reverse transcriptase	TERT	0.0063
1119	Peroxiredoxin-5, mitochondrial	PRDX5	0.0063
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0063
133	Dihydropterate synthase	sulI	0.0063
3809	Estrogen-related receptor gamma	ESRRG	0.0062
4237	50S ribosomal protein L22	rplV	0.0062
4203	Histamine N-methyltransferase	HNMT	0.0061
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0061
94	5-hydroxytryptamine 4 receptor	HTR4	0.0061
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0061
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0061
5923	Microtubule-associated protein tau	MAPT	0.006
5924	Microtubule-associated protein 4	MAP4	0.006
176	30S ribosomal protein S10	rpsJ	0.006
6175	30S ribosomal protein S10	rpsJ	0.006
4117	Probable pyruvate-flavodoxin oxidoreductase	ydbK	0.006
185	Vasopressin V1a receptor	AVPR1A	0.006
6103	Arylamine N-acetyltransferase 1	NAT1	0.0059
633	Penicillin-binding proteins 1A/1B	pbpA	0.0059
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0059
1650	Heme carrier protein 1	SLC46A1	0.0059
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0059
3382	Glycolipid transfer protein	GLTP	0.0058
322	Vasopressin V2 receptor	AVPR2	0.0058
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0058
346	Thyroid hormone receptor beta-1	THRB	0.0058
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0058
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0058
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0057
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0057
685	Oxygen-insensitive NADPH nitroreductase	nfsA	0.0057
6945	Oxygen-insensitive NADPH nitroreductase	rdxA	0.0057
2449	Tubulin alpha-3 chain	TUBA1A	0.0056
163	D(1B) dopamine receptor	DRD5	0.0056
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0056
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0056
856	Vitamin D3 receptor	VDR	0.0055
936	Ephrin type-A receptor 2	EPHA2	0.0055
162	Retinoic acid receptor gamma-1	RARG	0.0055
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0055
6174	50S ribosomal protein L32	rpmF	0.0055
319	Opioid receptor, sigma 1	OPRS1	0.0055
814	Ryanodine receptor 1	RYR1	0.0055
1629	Transcription factor AP-1	JUN	0.0054
477	DNA topoisomerase 4 subunit A	parC	0.0054
886	DNA topoisomerase 4 subunit A	parC	0.0054
6226	DNA topoisomerase 4 subunit A	parC	0.0054
404	DNA gyrase subunit A	gyrA	0.0053
6224	DNA gyrase subunit A	gyrA	0.0053
4103	Proteasome subunit beta type 2	PSMB2	0.0052
4102	Proteasome subunit beta type 5	PSMB5	0.0052
4101	Proteasome subunit beta type 1	PSMB1	0.0052
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0052
6126	Carbonic anhydrase 7	CA7	0.0052
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.0051
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.0051
887	DNA gyrase subunit B	gyrB	0.0051
4150	DNA gyrase subunit B	gyrB	0.0051
6225	DNA gyrase subunit B	gyrB	0.0051
461	Glycine receptor subunit alpha-3	GLRA3	0.0051
1992	Vitamin D-binding protein	GC	0.0051
2616	Ganglioside GM2 activator	GM2A	0.0051
2499	Tubulin beta-2C chain	TUBB2C	0.0051
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.005
1275	Estrogen sulfotransferase	SULT1E1	0.005
2320	Thymidine kinase, cytosolic	TK1	0.005
518	Peroxidase/catalase T	katG	0.005
6027	Alkaline phosphatase, tissue-nonspecific isozyme	ALPL	0.005
6163	Copper-transporting ATPase 2	ATP7B	0.0049
6165	Copper-transporting ATPase 1	ATP7A	0.0049
1178	Adenosine A2a receptor	ADORA2A	0.0049
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0049
229	Retinoic acid receptor beta	RARB	0.0049
896	Glutathione S-transferase Mu 1	GSTM1	0.0048
4210	Toll-like receptor 4	TLR4	0.0048
6184	D-alanyl-D-alanine carboxypeptidase dacC	dacC	0.0048
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0048
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0048
4192	DNA topoisomerase 2-beta	TOP2B	0.0048
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0048
730	Retinoic acid receptor alpha	RARA	0.0048
6677	Myelin P2 protein	PMP2	0.0047
4238	50S ribosomal protein L4	rplD	0.0047
5578	50S ribosomal protein L4	rplD	0.0047
6173	50S ribosomal protein L4	rplD	0.0047
6219	50S ribosomal protein L4	rplD	0.0047
4122	Histone deacetylase 2	HDAC2	0.0047
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0047
683	Potassium transporter	GK0582	0.0047
6824	Tyrosine-protein kinase Lyn	LYN	0.0046
1648	Elastin	ELN	0.0046
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0046
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0046
3639	Thymidine phosphorylase	deoA	0.0046
3936	Thymidine phosphorylase	TYMP	0.0046
199	Monocarboxylate transporter 8	SLC16A2	0.0046
84	Nuclear receptor 0B1	NR0B1	0.0046
1291	cAMP response element-binding protein	CREB1	0.0045
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0045
54	Prothrombin	F2	0.0045
527	Prostacyclin receptor	PTGIR	0.0045
284	DNA-directed RNA polymerase beta chain	rpoB	0.0045
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0045
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0045
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0045
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0045
4226	Uridine phosphorylase 2	UPP2	0.0045
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0045
115	Penicillin-binding protein 2	mrdA	0.0044
6069	Penicillin-binding protein 2	mrdA	0.0044
6118	Penicillin-binding protein 2	penA	0.0044
6187	Penicillin-binding protein 2	pbpA	0.0044
6686	Penicillin-binding protein 2	pbp2	0.0044
6939	Penicillin-binding protein 2	mrdA	0.0044
7163	Penicillin-binding protein 2	pbpA	0.0044
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0044
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0044
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0044
1196	Complement decay-accelerating factor	CD55	0.0044
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0044
130	Prostacyclin synthase	PTGIS	0.0044
2599	Tyrosine-protein kinase HCK	HCK	0.0044
2178	Metabotropic glutamate receptor 5	GRM5	0.0044
5645	DNA topoisomerase 4 subunit B	parE	0.0044
6227	DNA topoisomerase 4 subunit B	parE	0.0044
6033	High affinity interleukin-8 receptor A	CXCR1	0.0044
581	Cytochrome P450 2R1	CYP2R1	0.0043
1483	Membrane copper amine oxidase	AOC3	0.0043
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0043
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0043
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0042
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0042
65	Matrix metalloproteinase-9	Not Available	0.0042
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0042
5934	Cytochrome P450 26A1	CYP26A1	0.0042
4225	Uridine phosphorylase 1	UPP1	0.0042
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0042
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0041
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0041
489	Monocarboxylate transporter 2	SLC16A7	0.0041
293	Gamma-glutamyl hydrolase	GGH	0.0041
5798	Mitogen-activated protein kinase 11	MAPK11	0.0041
16	Adenosine A1 receptor	ADORA1	0.0041
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0041
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0041
3868	Calcineurin subunit B isoform 2	PPP3R2	0.004
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.004
7	Nitric oxide synthase, inducible	NOS2	0.004
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.004
6508	Putative uncharacterized protein	srtB	0.004
6543	Putative uncharacterized protein	tcp14	0.004
6615	Putative uncharacterized protein	MT0785	0.004
6623	Putative uncharacterized protein	Not Available	0.004
6806	Putative uncharacterized protein	AGR_C_2535	0.004
6813	Putative uncharacterized protein	SAV4671	0.004
6815	Putative uncharacterized protein	AFE_1514	0.004
6819	Putative uncharacterized protein	RUMGNA_03254	0.004
6825	Putative uncharacterized protein	CV_3270	0.004
4311	tRNA	TRDMT1	0.004
4325	tRNA	trmD	0.004
4328	tRNA	trmD	0.004
4161	Furin	FURIN	0.004
634	Squalene monooxygenase	SQLE	0.004
7196	Squalene monooxygenase	ERG1	0.004
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.004
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0039
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0039
1129	C-C chemokine receptor type 5	CCR5	0.0039
6067	Penicillin binding protein 2a	mecA	0.0038
413	Amidophosphoribosyltransferase	PPAT	0.0038
2515	Amidophosphoribosyltransferase	purF	0.0038
3714	Amidophosphoribosyltransferase	purF	0.0038
2808	Chloramphenicol acetyltransferase 3	cat3	0.0038
751	Potassium channel subfamily K member 6	KCNK6	0.0038
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0038
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0038
1760	Aminopeptidase N	ANPEP	0.0038
6843	Aminopeptidase N	pepN	0.0038
85	Growth hormone receptor	GHR	0.0038
6167	Organic solute transporter subunit beta	OSTB	0.0037
6166	Organic solute transporter subunit alpha	OSTA	0.0037
3426	Glutamine synthetase	glnA	0.0037
3987	Glutamine synthetase	GLUL	0.0037
723	Cytosolic phospholipase A2	PLA2G4A	0.0037
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0037
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0037
1525	Heparin-binding growth factor 2	FGF2	0.0037
2216	Fibroblast growth factor receptor 4	FGFR4	0.0037
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0037
3616	Fatty acid-binding protein, epidermal	FABP5	0.0036
5431	Lipid binding protein	Not Available	0.0036
5433	UPF0230 protein TM_1468	TM_1468	0.0036
5430	Hepatocyte nuclear factor 4-gamma	HNF4G	0.0036
1630	Integrin beta-2	ITGB2	0.0036
976	Platelet glycoprotein IX	GP9	0.0036
819	Penicillin-binding protein 4	dacB	0.0036
2021	Thrombomodulin	THBD	0.0035
3808	Dihydropteroate synthase 2	folP2	0.0035
3601	Dihydropteroate synthase 1	folP1	0.0035
3807	Dihydropteroate synthase 1	folP1	0.0035
2112	Toll-like receptor 9	TLR9	0.0035
2417	Chloramphenicol acetyltransferase	cat	0.0035
3278	Chloramphenicol acetyltransferase	cat	0.0035
172	Potassium channel subfamily K member 1	KCNK1	0.0035
6837	Serine/threonine-protein kinase 17B	STK17B	0.0035
6836	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	HIBCH	0.0035
2810	Dr hemagglutinin structural subunit	draA	0.0035
939	50S ribosomal protein L3	rplC	0.0035
153	Dopamine beta-hydroxylase	DBH	0.0035
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0034
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0034
2207	Rhodopsin	RHO	0.0033
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0033
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.0033
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0033
233	Potassium channel subfamily K member 2	KCNK2	0.0033
6459	Glycodelin	PAEP	0.0033
5432	Trafficking protein particle complex subunit 3	TRAPPC3	0.0033
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0033
5880	Thrombopoietin receptor	MPL	0.0033
707	72 kDa type IV collagenase	MMP2	0.0033
1867	Major prion protein	PRNP	0.0032
6218	Pannexin-1	PANX1	0.0032
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0032
174	Sigma 1-type opioid receptor	SIGMAR1	0.0032
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0032
2107	Microtubule-associated protein 1A	MAP1A	0.0032
595	Fibrinogen alpha chain	FGA	0.0032
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0032
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0032
140	30S ribosomal protein S9	rpsI	0.0031
6719	30S ribosomal protein S9	rpsI	0.0031
6725	30S ribosomal protein S9	rpsI	0.0031
3086	Plasmepsin-2	Not Available	0.0031
1227	Cytochrome b	MT-CYB	0.0031
6386	Cytochrome b	petB	0.0031
6937	Cytochrome b	MT-CYB	0.0031
674	Dihydroorotate dehydrogenase homolog, mitochondrial	PFF0160c	0.0031
3760	Penicillin-binding protein 5 precursor	dacA	0.0031
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.003
2578	Tubulin beta-3 chain	TUBB3	0.003
6656	UDP-glucuronosyltransferase 3A1	UGT3A1	0.003
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.003
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.003
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.003
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.003
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.003
2285	Streptogramin A acetyltransferase	vatD	0.003
283	SEC14-like protein 2	SEC14L2	0.003
702	UMP-CMP kinase	CMPK1	0.003
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.003
3611	Cytidine deaminase	cdd	0.003
3707	Cytidine deaminase	cdd	0.003
4211	Cytidine deaminase	CDA	0.003
3937	Fatty-acid amide hydrolase	FAAH	0.0029
1714	Mitogen-activated protein kinase 3	MAPK3	0.0029
3813	Fibrinogen gamma chain	FGG	0.0029
3812	Fibrinogen beta chain [Contains: Fibrinopeptide B]	FGB	0.0029
6044	Serum paraoxonase/lactonase 3	PON3	0.0029
3950	Cell division protein kinase 9	CDK9	0.0029
3968	Cell division protein kinase 8	CDK8	0.0029
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0028
1435	Synaptic vesicle glycoprotein 2A	SV2A	0.0028
605	Fumarate reductase flavoprotein subunit	frdA	0.0028
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0028
3673	Fumarate reductase flavoprotein subunit	fccA	0.0028
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0028
6549	Fumarate reductase flavoprotein subunit	frdA	0.0028
563	Thyroid peroxidase	TPO	0.0028
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0028
78	Acetyl-CoA acetyltransferase, mitochondrial	ACAT1	0.0028
6207	30S ribosomal protein S14	rpsN	0.0028
6209	30S ribosomal protein S19	rpsS	0.0028
6712	30S ribosomal protein S19	rpsS	0.0028
6726	30S ribosomal protein S19	rpsS	0.0028
164	Histamine H4 receptor	HRH4	0.0028
1278	Pro-epidermal growth factor	EGF	0.0028
1200	AMBP protein	AMBP	0.0028
3866	Serum amyloid A protein	SAA1	0.0028
1932	Apolipoprotein E	APOE	0.0028
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0027
6232	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	GNAS	0.0027
6233	Adenylate cyclase type 2	ADCY2	0.0027
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0027
6234	Adenylate cyclase type 5	ADCY5	0.0027
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0027
1144	Hepatocyte growth factor receptor	MET	0.0027
572	Integrin alpha-L	ITGAL	0.0027
4173	Tyrosine-protein kinase JAK2	JAK2	0.0027
2404	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PIK3CG	0.0027
2159	Quinone oxidoreductase	CRYZ	0.0027
760	Fibroblast growth factor 1	FGF1	0.0027
1262	Corticotropin-lipotropin	POMC	0.0027
889	3-oxoacyl-[acyl-carrier-protein] synthase 1	fabB	0.0027
6860	3-oxoacyl-[acyl-carrier-protein] synthase 1	kasA	0.0027
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0026
6228	Nuclear receptor coactivator 1	NCOA1	0.0026
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0026
5997	Tumor necrosis factor ligand superfamily member 11	TNFSF11	0.0026
804	Mitochondrial folate transporter/carrier	SLC25A32	0.0026
718	Folate receptor gamma	FOLR3	0.0026
299	Folate receptor beta	FOLR2	0.0026
484	Tyrosine-protein kinase ABL2	ABL2	0.0025
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0025
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0025
3959	Cell division protein kinase 4	CDK4	0.0025
1385	Angiotensin-converting enzyme 2	ACE2	0.0025
4252	Penicillin-binding protein 5	dacA	0.0025
3913	Glutamic acid decarboxylase	GAD65	0.0025
6151	Monocarboxylate transporter 10	SLC16A10	0.0025
6344	ATP synthase subunit gamma, mitochondrial	ATP5C1	0.0025
6343	ATP synthase subunit beta, mitochondrial	ATP5B	0.0025
6342	ATP synthase subunit alpha, mitochondrial	ATP5A1	0.0025
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0025
3482	Cell division protein kinase 7	CDK7	0.0025
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0025
2300	Lysozyme	E	0.0024
3633	Lysozyme	R	0.0024
5597	Lysozyme	17	0.0024
1792	Tissue-type plasminogen activator	PLAT	0.0024
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0024
544	Potassium voltage-gated channel subfamily E member 1	KCNE1	0.0024
2347	Proto-oncogene serine/threonine-protein kinase Pim-1	PIM1	0.0024
159	Penicillin-binding protein 2B	penA	0.0024
6121	Penicillin-binding protein 2B	penA	0.0024
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0024
6231	Pepsin A	PGA3	0.0024
5852	Type-2 angiotensin II receptor	AGTR2	0.0024
6171	Solute carrier family 28 member 3	SLC28A3	0.0024
6048	Troponin C, skeletal muscle	TNNC2	0.0024
1770	Phospholipase C	PLCL1	0.0024
2841	Phospholipase C	plc	0.0024
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0024
642	3-oxo-5-alpha-steroid 4-dehydrogenase 2	SRD5A2	0.0023
3955	Cell division protein kinase 6	CDK6	0.0023
4221	Vascular endothelial growth factor	VEGF	0.0023
5816	Cadherin-5	CDH5	0.0023
332	Beta-lactamase	blaZ	0.0023
2478	Beta-lactamase	ampC	0.0023
2613	Beta-lactamase	ampC	0.0023
2635	Beta-lactamase	ampC	0.0023
2700	Beta-lactamase	penP	0.0023
5445	Beta-lactamase	blaB	0.0023
6019	Beta-lactamase	SHV-7	0.0023
6701	Beta-lactamase	cphA	0.0023
6241	Nuclear receptor coactivator 2	NCOA2	0.0023
2240	Cell division protein kinase 2	CDK2	0.0023
6501	Fatty acid-binding protein, liver	FABP1	0.0023
342	P protein [Includes: DNA-directed DNA polymerase	P	0.0023
612	P protein [Includes: DNA-directed DNA polymerase	P	0.0023
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0023
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0023
677	Choline-phosphate cytidylyltransferase A	PCYT1A	0.0022
4209	ATP-sensitive inward rectifier potassium channel 8	KCNJ8	0.0022
6259	(3R)-hydroxymyristoyl-acyl carrier protein dehydratase	fabZ	0.0022
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0022
6111	DNA polymerase epsilon subunit 4	POLE4	0.0022
6112	DNA polymerase epsilon subunit 3	POLE3	0.0022
6110	DNA polymerase epsilon subunit 2	POLE2	0.0022
6108	Ribonucleoside-diphosphate reductase subunit M2 B	RRM2B	0.0022
6109	DNA polymerase epsilon catalytic subunit A	POLE	0.0022
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.0022
267	Plasminogen activator inhibitor 1	SERPINE1	0.0022
2232	Interleukin-5	IL5	0.0022
298	Renin	REN	0.0021
1593	Mucin-2	MUC2	0.0021
6506	Stathmin-4	STMN4	0.0021
5818	Folate receptor alpha	FOLR1	0.0021
735	Alanine aminotransferase 1	GPT	0.0021
3904	Alanine aminotransferase 2	GPT2	0.0021
291	Nitric-oxide synthase, endothelial	NOS3	0.0021
3957	Adenosine deaminase	ADA	0.0021
331	Retinol-binding protein I, cellular	RBP1	0.0021
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.0021
3090	Chitosanase	csn	0.002
4149	Nuclear factor NF-kappa-B p100 subunit	NFKB2	0.002
5626	Nucleoside diphosphate kinase B	NME2	0.002
1742	D-HSCDK2	CDK2deltaT	0.002
1771	Cell division control protein 2 homolog	CDK1	0.002
3321	Cell division control protein 2 homolog	CRK2	0.002
6042	Prostaglandin reductase 2	PTGR2	0.002
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.002
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.002
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.002
4218	Ribonucleoside-diphosphate reductase M2 subunit	RRM2	0.002
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.002
6755	Poliovirus receptor	PVR	0.002
1058	Cell division protein kinase 5	CDK5	0.002
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.002
6221	Steroid hormone receptor ERR1	ESRRA	0.0019
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0019
1039	Histone deacetylase 9	HDAC9	0.0019
444	Alcohol dehydrogenase 1B	ADH1B	0.0019
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.0019
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0018
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0018
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0018
1253	Interferon gamma	IFNG	0.0018
5998	Toll-like receptor 8	TLR8	0.0018
712	Tubulin alpha chain	TUB1	0.0018
1968	ATP-sensitive inward rectifier potassium channel 12	KCNJ12	0.0018
565	Extracellular calcium-sensing receptor	CASR	0.0018
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0018
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0018
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0018
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0018
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0018
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0018
3312	Fatty acid-binding protein, brain	FABP7	0.0018
1198	Serum paraoxonase/arylesterase 1	PON1	0.0018
6223	Penicillin-binding protein 1C	pbpC	0.0018
1123	Eosinophil cationic protein	RNASE3	0.0018
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0017
613	Atrial natriuretic peptide receptor A	NPR1	0.0017
719	Retinoic acid receptor responder protein 1	RARRES1	0.0017
3587	Gastrotropin	FABP6	0.0017
770	Retinoic acid-induced protein 3	GPRC5A	0.0017
251	Alcohol dehydrogenase 1A	ADH1A	0.0017
268	Adenosine A2b receptor	ADORA2B	0.0017
1374	Natriuretic peptides B	NPPB	0.0017
131	Synaptic vesicular amine transporter	SLC18A2	0.0017
1827	Gap junction alpha-1 protein	GJA1	0.0017
1908	Vascular cell adhesion protein 1	VCAM1	0.0017
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.0017
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0017
5294	Nucleoside diphosphate kinase A	NME1	0.0017
144	Hemoglobin subunit alpha	HBA1	0.0017
3830	Calreticulin	CALR	0.0017
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0016
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0016
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0016
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0016
820	Glycine receptor subunit alpha-2	GLRA2	0.0016
6766	O-GlcNAcase BT_4395	BT_4395	0.0016
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0016
1268	Neuropeptide S receptor	NPSR1	0.0016
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0016
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0016
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0016
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0016
173	Toll-like receptor 7	TLR7	0.0016
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0016
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0016
2297	Genome polyprotein	Not Available	0.0016
2322	Genome polyprotein	Not Available	0.0016
2694	Genome polyprotein	Not Available	0.0016
2719	Genome polyprotein	Not Available	0.0016
2860	Genome polyprotein	Not Available	0.0016
2928	Genome polyprotein	Not Available	0.0016
3160	Genome polyprotein	Not Available	0.0016
3260	Genome polyprotein	Not Available	0.0016
4783	Genome polyprotein	Not Available	0.0016
5726	Genome polyprotein	Not Available	0.0016
5779	Genome polyprotein	Not Available	0.0016
5867	Genome polyprotein	Not Available	0.0016
6253	Genome polyprotein	Not Available	0.0016
6301	Genome polyprotein	Not Available	0.0016
6380	Genome polyprotein	Not Available	0.0016
6381	Genome polyprotein	Not Available	0.0016
6437	Genome polyprotein	Not Available	0.0016
6520	Genome polyprotein	Not Available	0.0016
6521	Genome polyprotein	Not Available	0.0016
6652	Genome polyprotein	Not Available	0.0016
6734	Genome polyprotein	Not Available	0.0016
6735	Genome polyprotein	Not Available	0.0016
6736	Genome polyprotein	Not Available	0.0016
6737	Genome polyprotein	Not Available	0.0016
6738	Genome polyprotein	Not Available	0.0016
6739	Genome polyprotein	Not Available	0.0016
6744	Genome polyprotein	Not Available	0.0016
6748	Genome polyprotein	Not Available	0.0016
6894	Genome polyprotein	Not Available	0.0016
6898	Genome polyprotein	Not Available	0.0016
6034	Hydroxyindole O-methyltransferase	ASMT	0.0016
6035	Nuclear receptor ROR-beta	RORB	0.0016
6036	Eosinophil peroxidase	EPX	0.0016
1313	Lactoylglutathione lyase	GLO1	0.0016
6168	Solute carrier family 22 member 16	SLC22A16	0.0016
3233	Bile acid receptor	NR1H4	0.0015
517	Alcohol dehydrogenase 1C	ADH1C	0.0015
569	Retinal dehydrogenase 2	ALDH1A2	0.0015
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0015
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.0015
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0015
6073	Potassium channel subfamily K member 9	KCNK9	0.0015
6072	Potassium channel subfamily K member 3	KCNK3	0.0015
1569	G1/S-specific cyclin-D1	CCND1	0.0015
1341	Histamine H3 receptor	HRH3	0.0014
611	Retinal dehydrogenase 1	ALDH1A1	0.0014
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0014
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0014
2129	Sucrase-isomaltase, intestinal	SI	0.0014
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.0014
3221	Cytochrome c4	cc4	0.0014
76	Nitric-oxide synthase, brain	NOS1	0.0014
765	Indoleamine 2,3-dioxygenase	IDO1	0.0014
277	Purine nucleoside phosphorylase	PNP	0.0014
2870	Purine nucleoside phosphorylase	punA	0.0014
2945	Purine nucleoside phosphorylase	punA	0.0014
4659	Purine nucleoside phosphorylase	TM_1596	0.0014
4825	Purine nucleoside phosphorylase	TTHA1435	0.0014
6211	Tubulin epsilon chain	TUBE1	0.0013
6212	Tubulin gamma-1 chain	TUBG1	0.0013
6210	Tubulin delta chain	TUBD1	0.0013
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0013
1152	Glycogen phosphorylase, muscle form	PYGM	0.0013
6131	Carbonic anhydrase 14	CA14	0.0013
1405	Thiopurine S-methyltransferase	TPMT	0.0013
6116	Gastric triacylglycerol lipase	LIPF	0.0012
822	Aldose reductase	AKR1B1	0.0012
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0012
694	Matrix protein 2	M	0.0012
3823	Cytokine receptor common gamma chain	IL2RG	0.0012
338	DNA polymerase	UL30	0.0012
379	DNA polymerase	UL54	0.0012
697	DNA polymerase	ORF28	0.0012
2482	DNA polymerase	43	0.0012
4104	DNA polymerase	BALF5	0.0012
6122	Carbonic anhydrase 3	CA3	0.0012
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0012
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0012
1295	Fatty acid synthase	FASN	0.0012
4948	Cytochrome c-553	Not Available	0.0012
4923	Cytochrome c3	DvMF_2499	0.0012
4945	Cytochrome c3	Not Available	0.0012
4949	Cytochrome c3	DVU_3171	0.0012
4968	Cytochrome c3	cytc3	0.0012
4997	Cytochrome c3	SO_2727	0.0012
5219	Cytochrome c3	cyd	0.0012
4902	Nine-heme cytochrome c	Ddes_2038	0.0012
3189	High-molecular-weight cytochrome c	hmcA	0.0012
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0012
6859	Protein S100-A4	S100A4	0.0012
754	Pancreatic triacylglycerol lipase	PNLIP	0.0011
724	Interleukin-2 receptor alpha chain	IL2RA	0.0011
717	Interleukin-2 receptor subunit beta	IL2RB	0.0011
1810	Protein S100-A1	S100A1	0.001
6097	Protein S100-A2	S100A2	0.001
4228	Keratin, type II cytoskeletal 7	KRT7	0.001
2461	D-alanyl-D-alanine carboxypeptidase	Not Available	0.001
5756	D-alanyl-D-alanine carboxypeptidase	dac	0.001
4386	Hemoglobin-like protein HbN	glbN	0.001
493	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	0.001
512	DNA-directed RNA polymerase alpha chain	rpoA	0.001
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.001
4041	Microsomal glutathione S-transferase 2	MGST2	0.001
1176	Mitogen-activated protein kinase 1	MAPK1	0.001
2473	Tyrosine-protein kinase CSK	CSK	0.001
2398	Tyrosine-protein kinase ZAP-70	ZAP70	0.001
2298	Cytochrome P450-cam	camC	0.001
2268	Cholesterol oxidase	choB	0.0009
2822	Cholesterol oxidase	choA	0.0009
6105	3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	0.0009
828	Phenylalanine-4-hydroxylase	PAH	0.0009
3109	Phenylalanine-4-hydroxylase	phhA	0.0009
1048	Protein S100-A13	S100A13	0.0009
2226	Protein S100-A12	S100A12	0.0009
2283	Steroid Delta-isomerase	ksi	0.0009
2920	Steroid Delta-isomerase	ksi	0.0009
390	Adenosine A3 receptor	ADORA3	0.0009
2132	Protein S100-B	S100B	0.0009
3404	Exotoxin A	eta	0.0008
22	30S ribosomal protein S4	rpsD	0.0008
6714	30S ribosomal protein S4	rpsD	0.0008
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0008
4954	Soluble cytochrome b558	Not Available	0.0008
4943	Cytochrome c6	petJ	0.0008
4916	Cyanoglobin	glbN	0.0008
4947	Bacterial hemoglobin	vhb	0.0008
4934	Cytochrome c-551	nirM	0.0008
5218	Cytochrome c-551	nirM	0.0008
4915	Cytochrome c-550	psbV	0.0008
4959	Cytochrome c-550	psbV	0.0008
5216	Cytochrome c-550	psbV	0.0008
4925	Cytochrome c-type protein SHP	shp	0.0008
5000	HemO	hemO	0.0008
4975	Cytochrome c-556	RPA3973	0.0008
4936	Cytochrome c2 iso-2	Not Available	0.0008
4994	Hemoglobin-like protein HbO	glbO	0.0008
4905	Cytochrome c2	Not Available	0.0008
4939	Cytochrome c2	cycA	0.0008
4964	Cytochrome c2	cycA	0.0008
4979	Cytochrome c2	cycA	0.0008
6673	Cytochrome c2	cycA	0.0008
4942	Diheme cytochrome c napB	napB	0.0008
4984	Neuroglobin	NGB	0.0008
4981	Iron-starvation protein PigA	pigA	0.0008
4998	Hemoglobin-like protein yjbI	yjbI	0.0008
4935	Cytochrome c-554	cycA1	0.0008
4909	CooA protein	cooA	0.0008
4910	Cytoglobin	CYGB	0.0008
4961	Hemophore HasA	hasA	0.0008
4904	Cytochrome c family protein	GSU1996	0.0008
644	Heme oxygenase 2	HMOX2	0.0008
4982	Heme oxygenase 2	pbsA2	0.0008
4971	Nonaheme cytochrome c	hmcA	0.0008
4907	Cytochrome c-L	moxG	0.0008
6865	Cytochrome c-L	moxG	0.0008
4937	Cytochrome oxidase subunit II	rcoxA	0.0008
4989	Cytochrome c551 peroxidase	ccp	0.0008
5222	Cytochrome c551 peroxidase	ccpA	0.0008
4931	Cytochrome P450 167A1	CYP167A1	0.0008
4976	Apocytochrome f	petA	0.0008
6407	Apocytochrome f	petA	0.0008
4764	Cytochrome P450 165C4	CYP165C4	0.0008
4999	Cytochrome P450 165B3	CYP165B3	0.0008
4960	Putative cytochrome P450-family protein	SCO7417	0.0008
4903	Methyl-accepting chemotaxis protein	Tar4	0.0008
4922	Cytochrome c, putative	SO_4144	0.0008
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0008
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0008
4972	P450cin	cinA	0.0008
4993	Hydroxylamine oxidoreductase	hao1	0.0008
4952	Catalase/peroxidase	katA	0.0008
3093	Catalase HPII	katE	0.0008
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0008
4031	Glutathione S-transferase A1	GSTA1	0.0008
1507	Cytochrome c	CYCS	0.0008
1649	Small inducible cytokine A2	CCL2	0.0008
2530	Protein kinase C theta type	PRKCQ	0.0008
1025	Aquaporin-1	AQP1	0.0008
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0008
2091	Endoplasmin	HSP90B1	0.0008
473	L-lactate dehydrogenase A chain	LDHA	0.0007
6316	ADP-ribosylation factor 1	ARF1	0.0007
6134	Sodium channel subunit beta-3	SCN3B	0.0007
6133	Sodium channel subunit beta-2	SCN2B	0.0007
6135	Sodium channel subunit beta-4	SCN4B	0.0007
6132	Sodium channel subunit beta-1	SCN1B	0.0007
6129	Carbonic anhydrase-related protein 11	CA11	0.0007
6127	Carbonic anhydrase-related protein	CA8	0.0007
6128	Carbonic anhydrase-related protein 10	CA10	0.0007
2408	Tyrosine-protein kinase SYK	SYK	0.0007
2511	MAP kinase-activated protein kinase 2	MAPKAPK2	0.0007
2290	ADP-ribosyl cyclase 2	BST1	0.0007
226	Gonadotropin-releasing hormone receptor	GNRHR	0.0007
1830	5'-nucleotidase	NT5E	0.0007
125	DNA polymerase beta	POLB	0.0007
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0006
6130	Carbonic anhydrase 13	CA13	0.0006
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0006
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0006
4920	Peroxidase/catalase	katG	0.0006
2119	Cytochrome b5	CYB5A	0.0006
4990	PpcA	ppcA	0.0006
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0006
3375	Acidic cytochrome c3	Not Available	0.0006
4988	Sulfite oxidase, mitochondrial	SUOX	0.0006
2915	Sensor protein fixL	fixL	0.0006
4944	Sensor protein fixL	fixL	0.0006
3570	Cytochrome P450 152A1	cypC	0.0006
4037	Hypothetical protein	GPX1	0.0006
4297	Hypothetical protein	SP_1951	0.0006
4521	Hypothetical protein	BC_2969	0.0006
4540	Hypothetical protein	TM_1070	0.0006
4555	Hypothetical protein	MT1739	0.0006
4569	Hypothetical protein	mshD	0.0006
4578	Hypothetical protein	PA3270	0.0006
4747	Hypothetical protein	PA3967	0.0006
5177	Hypothetical protein	TM_0096	0.0006
5194	Hypothetical protein	PA1204	0.0006
5240	Hypothetical protein	Rv2991	0.0006
5370	Hypothetical protein	TM_1158	0.0006
5710	Hypothetical protein	Tb927.5.1360	0.0006
4813	Heme oxygenase	hmuO	0.0006
5769	Heme oxygenase	Not Available	0.0006
4385	Cytochrome c'	Not Available	0.0006
4967	Cytochrome c'	cycA	0.0006
5038	Cytochrome c'	Not Available	0.0006
5223	Cytochrome c'	cycP	0.0006
4289	Cytochrome P450	TT_P0059	0.0006
6262	Cytochrome P450	staP	0.0006
4992	Cytochrome c peroxidase	Not Available	0.0006
2230	Catalase	CAT	0.0006
3249	Catalase	katA	0.0006
3625	Catalase	katA	0.0006
4539	Catalase	katA	0.0006
4941	Catalase	katB	0.0006
5221	Cytochrome c3, 13 kDa	Not Available	0.0006
3152	Cytochrome c''	cycA	0.0006
5220	Split-Soret cytochrome c	Ddes_2150	0.0006
3700	Cytochrome c-552 precursor	nrfA	0.0006
1721	Glycogen synthase kinase-3 beta	GSK3B	0.0005
3238	Multidrug resistance protein mexA	mexA	0.0005
3116	Bacterioferritin	bfr	0.0005
4906	Bacterioferritin	bfr	0.0005
4965	Bacterioferritin	bfr	0.0005
3173	Enolase	eno	0.0005
3709	Glycerol uptake facilitator protein	glpF	0.0005
3336	C4-dicarboxylate transport transcriptional regulatory protein dctD	dctD	0.0005
3393	TGF-beta receptor type-2	TGFBR2	0.0005
5489	Ribonucleoside-diphosphate reductase 1 subunit beta	nrdB	0.0005
6743	Non-fluorescent flavoprotein	luxF	0.0005
6753	Apolipoprotein M	APOM	0.0005
2528	Fatty acid metabolism regulator protein	fadR	0.0005
6740	Fatty acid metabolism regulator protein	fadR	0.0005
6752	Guanylyl cyclase-activating protein 1	GUCA1A	0.0005
394	Calcineurin subunit B isoform 1	PPP3R1	0.0005
6742	Recoverin	RCVRN	0.0005
6747	Chalcone/stilbene synthase family protein	MT1417	0.0005
6741	Peroxisomal 3,2-trans-enoyl-CoA isomerase	PECI	0.0005
6522	Hepatocyte nuclear factor 4-alpha	HNF4A	0.0005
6751	Gag polyprotein	gag	0.0005
6746	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	PPP3CA	0.0005
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0005
6749	Polyprotein	Not Available	0.0005
3670	Soluble cytochrome b562 precursor	cybC	0.0005
3411	Cytochrome P450 121	cyp121	0.0005
3291	Cytochrome c-552	cycA	0.0005
4927	Cytochrome c-552	nrfA	0.0005
4938	Cytochrome c-552	cycA	0.0005
4953	Cytochrome c-552	nrfA	0.0005
5217	Cytochrome c-552	cycM	0.0005
2617	Nitric oxide synthase oxygenase	nos	0.0005
2701	Nitric oxide synthase oxygenase	nos	0.0005
3102	Flavohemoprotein	hmp	0.0005
4969	Flavohemoprotein	hmp	0.0005
3007	Carbonic anhydrase 12	CA12	0.0005
4205	Carbonic anhydrase 9	CA9	0.0005
3127	Nitrite reductase	nirS	0.0005
3284	Nitrite reductase	nirS	0.0005
2852	DNA mismatch repair protein mutL	mutL	0.0005
5961	Insulin	INS	0.0005
2236	Casein kinase II subunit alpha	CSNK2A1	0.0005
5278	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1	PAPSS1	0.0005
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0005
6527	Lymphocyte antigen 96	LY96	0.0005
3191	Histidinol dehydrogenase	hisD	0.0005
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0005
4608	Putative cytochrome P450	SCO1207	0.0004
4963	Putative cytochrome P450	SCO2884	0.0004
6254	Putative cytochrome P450	SCO6998	0.0004
3405	Quinohaemoprotein ethanol dehydrogenase type-1	qheDH	0.0004
6750	ADP-ribosylation factor 6	ARF6	0.0004
4373	Medium-chain-fatty-acid--CoA ligase	Not Available	0.0004
4692	A/G-specific adenine glycosylase	mutY	0.0004
6524	Protein tonB	tonB	0.0004
358	Cystathionine beta-synthase	CBS	0.0004
2435	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase	lpxC	0.0004
6613	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase	lpxC	0.0004
693	Hemoglobin subunit beta	HBB	0.0004
2802	Endoglucanase G	celCCG	0.0004
340	Apoptotic protease-activating factor 1	APAF1	0.0004
2391	Ferrochelatase	hemH	0.0004
6502	Ferrochelatase	DKFZp686P18130	0.0004
1591	Ferrochelatase, mitochondrial	FECH	0.0004
6268	Hydroxyacid oxidase 1	HAO1	0.0004
810	Heme oxygenase 1	HMOX1	0.0004
3391	Heme oxygenase 1	pbsA1	0.0004
864	Gag-Pol polyprotein	gag-pol	0.0003
2237	Gag-Pol polyprotein	gag-pol	0.0003
2326	Gag-Pol polyprotein	gag-pol	0.0003
2451	Gag-Pol polyprotein	gag-pol	0.0003
2901	Gag-Pol polyprotein	gag-pol	0.0003
3165	Gag-Pol polyprotein	gag-pol	0.0003
3722	Gag-Pol polyprotein	gag-pol	0.0003
6306	Gag-Pol polyprotein	gag-pol	0.0003
6624	Gag-Pol polyprotein	gag-pol	0.0003
2101	Glutathione-requiring prostaglandin D synthase	HPGDS	0.0003
825	Arsenical pump-driving ATPase	ASNA1	0.0003
3435	Arsenical pump-driving ATPase	arsA	0.0003
486	Serine/threonine-protein kinase ALS2CR7	CDK15	0.0003
2105	ATP-binding cassette sub-family G member 1	ABCG1	0.0003
377	Beta-adrenergic receptor kinase 1	ADRBK1	0.0003
510	Serine/threonine-protein kinase receptor R3	ACVRL1	0.0003
733	Activin receptor type 1B	ACVR1B	0.0003
225	NEDD8-activating enzyme E1 regulatory subunit	NAE1	0.0003
745	Anti-Muellerian hormone type-2 receptor	AMHR2	0.0003
483	A-Raf proto-oncogene serine/threonine-protein kinase	ARAF	0.0003
21	Beta-adrenergic receptor kinase 2	ADRBK2	0.0003
154	AFG3-like protein 2	AFG3L2	0.0003
395	ALK tyrosine kinase receptor	Not Available	0.0003
6496	Cytochrome c oxidase subunit 8A, mitochondrial	COX8A	0.0003
6493	Cytochrome c oxidase subunit 6C	COX6C	0.0003
6495	Cytochrome c oxidase subunit 7C, mitochondrial	COX7C	0.0003
6499	Cytochrome c oxidase polypeptide 7A1, mitochondrial	COX7A1	0.0003
6494	Cytochrome c oxidase subunit 7B, mitochondrial	COX7B	0.0003
6491	Cytochrome c oxidase subunit 5A, mitochondrial	COX5A	0.0003
6498	Cytochrome c oxidase subunit 6B1	COX6B1	0.0003
6497	Cytochrome c oxidase subunit 6A2, mitochondrial	COX6A2	0.0003
6489	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	COX4I1	0.0003
5793	Cytochrome c oxidase subunit 2	MT-CO2	0.0003
6559	Cytochrome c oxidase subunit 2	ctaC	0.0003
6669	Cytochrome c oxidase subunit 2	ctaC	0.0003
6490	Cytochrome c oxidase subunit 3	MT-CO3	0.0003
371	Cytochrome c oxidase subunit 1	MT-CO1	0.0003
6558	Cytochrome c oxidase subunit 1	ctaD	0.0003
292	Activin receptor type-1	ACVR1	0.0003
849	Activated CDC42 kinase 1	TNK2	0.0003
2540	Choloylglycine hydrolase	cbh	0.0003
2427	Ferrichrome-iron receptor	fhuA	0.0003
704	Long-chain-fatty-acid--CoA ligase 1	ACSL1	0.0003
821	Acetyl-coenzyme A synthetase 2-like, mitochondrial	ACSS1	0.0003
386	Acetyl-coenzyme A synthetase, cytoplasmic	ACSS2	0.0003
297	Adenylate cyclase type 1	ADCY1	0.0003
289	Cytosolic purine 5'-nucleotidase	NT5C2	0.0003
6264	cAMP-dependent protein kinase inhibitor alpha	PKIA	0.0003
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.0003
6263	cAMP-dependent protein kinase catalytic subunit alpha	PRKACA	0.0003
740	Argininosuccinate synthase	ASS1	0.0002
865	Argininosuccinate synthase	ASS1	0.0002
2680	Argininosuccinate synthase	argG	0.0002
3194	Argininosuccinate synthase	argG	0.0002
661	ADP/ATP translocase 1	SLC25A4	0.0002
6021	Adenosine kinase	ADK	0.0002
242	Asparagine synthetase [glutamine-hydrolyzing]	ASNS	0.0002
6500	Phospholipase A2	PLA2G1B	0.0002

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB08828 - Vismodegib

Targets

Enzymes

Transporters

Carriers

Predictions