DT-Web

DB01156 - Bupropion


Identification
Name Bupropion
Accession Number DB01156 (APRD00621)
Type small molecule
Description A unicyclic, aminoketone antidepressant. The mechanism of its therapeutic actions is not well understood, but it does appear to block dopamine uptake. The hydrochloride is available as an aid to smoking cessation treatment. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 239.741
Groups approved
Monoisotopic Weight 239.10769191
Pharmacology
Indication For the treatment of depression and as aid to smoking cessation.
Mechanism of action Bupropion selectively inhibits the neuronal reuptake of dopamine, norepinephrine, and serotonin; actions on dopaminergic systems are more significant than imipramine or amitriptyline whereas the blockade of norepinephrine and serotonin reuptake at the neuronal membrane is weaker for bupropion than for tricyclic antidepressants. The increase in norepinephrine may attenuate nicotine withdrawal symptoms and the increase in dopamine at neuronal sites may reduce nicotine cravings and the urge to smoke. Bupropion exhibits moderate anticholinergic effects.
Absorption For sustained release, peak plasma concentrations are achieved within 3 hours.
Protein binding 84 %
Biotransformation Reduction of the carbonyl groupand/or hydroxylation of the tert-butyl group of bupropion.
Route of elimination Bupropion is extensively metabolized in humans. Oxidation of the bupropion side chain results in the formation of a glycine conjugate of metachlorobenzoic acid, which is then excreted as the major urinary metabolite. Following oral administration of 200 mg of 14C-bupropion in humans, 87% and 10% of the radioactive dose were recovered in the urine and feces, respectively. However, the fraction of the oral dose of bupropion excreted unchanged was only 0.5%, a finding consistent with the extensive metabolism of bupropion.
Toxicity Symptoms of overdose include seizures, hallucinations, loss of consciousness, tachycardia, and cardiac arrest.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Carbamazepine Carbamazepine, a strong CYP2B6 inducer, may increase the metabolism of bupropion. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of bupropion if carbamazepine is initiated, discontinued or dose changed.
Cyclosporine Bupropion may decrease the therapeutic effect of cyclosporine.
Isocarboxazid Possible severe adverse reaction with this combination
Phenelzine Possible severe adverse reaction with this combination
Rasagiline Possible severe adverse reaction with this combination
Rifabutin Rifampin reduces bupropion levels
Rifampin Rifampin reduces bupropion levels
Ritonavir Ritonavir increases the effect and toxicity of bupropion
Thioridazine Bupropion may increase the effect and toxicity of thioridazine.
Thiotepa Thiotepa, a strong CYP2B6 inhibitor, may decrease the metabolism and clearance of Bupropion, a CYP2B6 substrate. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of Bupropion if Thiotepa is initiated, discontinued or dose changed.
Tranylcypromine The MAO inhibitor, Tranylcypromine, may increase the central neurotoxic effects of the Bupropion. These agents should not be administered within 14 days of each other.
Triprolidine The CNS depressants, Triprolidine and Bupropion, may increase adverse/toxic effects due to additivity. Monitor for increased CNS depressant effects during concomitant therapy.
Zuclopenthixol Bupropion, a strong CYP2D6 inhibitor, may increase the serum concentration of zuclopenthixol by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of zuclopenthixol if bupropion is initiated, discontinued or dose changed.
Food Interactions
  • Take without regard to meals.
  • Avoid St.John's Wort.
  • Avoid alcohol.

Targets


Sodium-dependent dopamine transporter
Name Sodium-dependent dopamine transporter
Gene Name SLC6A3
Pharmacological action yes
Actions inhibitor
References
  • Miller DK, Sumithran SP, Dwoskin LP: Bupropion inhibits nicotine-evoked [(3)H]overflow from rat striatal slices preloaded with [(3)H]dopamine and from rat hippocampal slices preloaded with [(3)H]norepinephrine. J Pharmacol Exp Ther. 2002 Sep;302(3):1113-22. - Pubmed
  • Meyer JH, Goulding VS, Wilson AA, Hussey D, Christensen BK, Houle S: Bupropion occupancy of the dopamine transporter is low during clinical treatment. Psychopharmacology (Berl). 2002 Aug;163(1):102-5. Epub 2002 Jul 13. - Pubmed
  • Kugaya A, Seneca NM, Snyder PJ, Williams SA, Malison RT, Baldwin RM, Seibyl JP, Innis RB: Changes in human in vivo serotonin and dopamine transporter availabilities during chronic antidepressant administration. Neuropsychopharmacology. 2003 Feb;28(2):413-20. Epub 2002 Jul 19. - Pubmed
  • Learned-Coughlin SM, Bergstrom M, Savitcheva I, Ascher J, Schmith VD, Langstrom B: In vivo activity of bupropion at the human dopamine transporter as measured by positron emission tomography. Biol Psychiatry. 2003 Oct 15;54(8):800-5. - Pubmed
  • Szabo Z, Argyelan M, Kanyo B, Pavics L, Janka Z: [Change of dopamine transporter activity (DAT) during the action of bupropion (in depression)] Neuropsychopharmacol Hung. 2004 Jun;6(2):79-81. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
  • Tatsumi M, Groshan K, Blakely RD, Richelson E: Pharmacological profile of antidepressants and related compounds at human monoamine transporters. Eur J Pharmacol. 1997 Dec 11;340(2-3):249-58. - Pubmed
  • Stahl SM, Pradko JF, Haight BR, Modell JG, Rockett CB, Learned-Coughlin S: A Review of the Neuropharmacology of Bupropion, a Dual Norepinephrine and Dopamine Reuptake Inhibitor. Prim Care Companion J Clin Psychiatry. 2004;6(4):159-166. - Pubmed
DTHybrid score 0.5145
Sodium-dependent noradrenaline transporter
Name Sodium-dependent noradrenaline transporter
Gene Name SLC6A2
Pharmacological action yes
Actions inhibitor
References
  • Bondarev ML, Bondareva TS, Young R, Glennon RA: Behavioral and biochemical investigations of bupropion metabolites. Eur J Pharmacol. 2003 Aug 1;474(1):85-93. - Pubmed
  • Mitchell HA, Ahern TH, Liles LC, Javors MA, Weinshenker D: The effects of norepinephrine transporter inactivation on locomotor activity in mice. Biol Psychiatry. 2006 Nov 15;60(10):1046-52. Epub 2006 Aug 7. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
  • Stahl SM, Pradko JF, Haight BR, Modell JG, Rockett CB, Learned-Coughlin S: A Review of the Neuropharmacology of Bupropion, a Dual Norepinephrine and Dopamine Reuptake Inhibitor. Prim Care Companion J Clin Psychiatry. 2004;6(4):159-166. - Pubmed
DTHybrid score 0.5334
Neuronal acetylcholine receptor subunit alpha-3
Name Neuronal acetylcholine receptor subunit alpha-3
Gene Name CHRNA3
Pharmacological action unknown
Actions antagonist
References
  • Fryer JD, Lukas RJ: Noncompetitive functional inhibition at diverse, human nicotinic acetylcholine receptor subtypes by bupropion, phencyclidine, and ibogaine. J Pharmacol Exp Ther. 1999 Jan;288(1):88-92. - Pubmed
  • Slemmer JE, Martin BR, Damaj MI: Bupropion is a nicotinic antagonist. J Pharmacol Exp Ther. 2000 Oct;295(1):321-7. - Pubmed
DTHybrid score 0.3217

Enzymes


Cytochrome P450 2B6
Name Cytochrome P450 2B6
Gene Name CYP2B6
Actions substrate,inhibitor
References
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Walsky RL, Astuccio AV, Obach RS: Evaluation of 227 drugs for in vitro inhibition of cytochrome P450 2B6. J Clin Pharmacol. 2006 Dec;46(12):1426-38. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
  • Lewis DF, Modi S, Dickins M: Structure-activity relationship for human cytochrome P450 substrates and inhibitors. Drug Metab Rev. 2002 Feb-May;34(1-2):69-82. - Pubmed
  • Hesse LM, Venkatakrishnan K, Court MH, von Moltke LL, Duan SX, Shader RI, Greenblatt DJ: CYP2B6 mediates the in vitro hydroxylation of bupropion: potential drug interactions with other antidepressants. Drug Metab Dispos. 2000 Oct;28(10):1176-83. - Pubmed
  • Jefferson JW, Pradko JF, Muir KT: Bupropion for major depressive disorder: Pharmacokinetic and formulation considerations. Clin Ther. 2005 Nov;27(11):1685-95. - Pubmed
  • Foley KF, DeSanty KP, Kast RE: Bupropion: pharmacology and therapeutic applications. Expert Rev Neurother. 2006 Sep;6(9):1249-65. - Pubmed
DTHybrid score 0.4172
Cytochrome P450 2D6
Name Cytochrome P450 2D6
Gene Name CYP2D6
Actions substrate,inhibitor
References
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
  • Foley KF, DeSanty KP, Kast RE: Bupropion: pharmacology and therapeutic applications. Expert Rev Neurother. 2006 Sep;6(9):1249-65. - Pubmed
DTHybrid score 0.7002
Cytochrome P450 1A2
Name Cytochrome P450 1A2
Gene Name CYP1A2
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.5503
Cytochrome P450 2A6
Name Cytochrome P450 2A6
Gene Name CYP2A6
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3765
Cytochrome P450 2C8
Name Cytochrome P450 2C8
Gene Name CYP2C8
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4242
Cytochrome P450 2C9
Name Cytochrome P450 2C9
Gene Name CYP2C9
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.5994
Cytochrome P450 2E1
Name Cytochrome P450 2E1
Gene Name CYP2E1
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3812
Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.8313

Carriers


Predictions


Id Partner name Gene Name Score
6016 Cytochrome P450 2C19 CYP2C19 0.4273
1588 Multidrug resistance protein 1 ABCB1 0.3258
824 Sodium-dependent serotonin transporter SLC6A4 0.2897
4118 Cytochrome P450 3A5 CYP3A5 0.2598
6107 Cytochrome P450 3A7 CYP3A7 0.1984
6024 Cytochrome P450 1A1 CYP1A1 0.1869
587 Serum albumin ALB 0.159
492 Histamine H1 receptor HRH1 0.1411
556 Alpha-1A adrenergic receptor ADRA1A 0.1388
20 Prostaglandin G/H synthase 1 PTGS1 0.117
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.1152
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.1069
1075 Alkaline phosphatase, placental-like ALPPL2 0.1024
3941 Amine oxidase [flavin-containing] A MAOA 0.0964
502 5-hydroxytryptamine 2A receptor HTR2A 0.0962
632 Alpha-1B adrenergic receptor ADRA1B 0.0891
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0858
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0853
6106 Cytochrome P450 2C18 CYP2C18 0.0852
318 Alpha-2A adrenergic receptor ADRA2A 0.084
3811 Cytochrome P450 19A1 CYP19A1 0.0825
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0815
3939 Amine oxidase [flavin-containing] B MAOB 0.0806
131 Synaptic vesicular amine transporter SLC18A2 0.0777
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0759
831 D(2) dopamine receptor DRD2 0.0673
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0662
6144 Solute carrier family 22 member 2 SLC22A2 0.0654
6145 Solute carrier family 22 member 1 SLC22A1 0.0647
766 Beta-2 adrenergic receptor ADRB2 0.0647
590 5-hydroxytryptamine 2C receptor HTR2C 0.0639
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0632
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0617
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0611
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0598
847 Mu-type opioid receptor OPRM1 0.0596
290 Prostaglandin G/H synthase 2 PTGS2 0.0594
862 Multidrug resistance-associated protein 1 ABCC1 0.0592
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0575
320 5-hydroxytryptamine 1A receptor HTR1A 0.0571
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.057
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0562
118 Organic cation/carnitine transporter 2 SLC22A5 0.0552
193 Beta-1 adrenergic receptor ADRB1 0.0546
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0533
341 5-hydroxytryptamine 3 receptor HTR3A 0.0523
1729 Solute carrier family 22 member 6 SLC22A6 0.0519
1898 Cytochrome P450 1B1 CYP1B1 0.0514
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0486
6147 Solute carrier family 22 member 3 SLC22A3 0.048
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0475
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0468
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0462
23 D(1A) dopamine receptor DRD1 0.0453
789 Alpha-1D adrenergic receptor ADRA1D 0.0443
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0439
3923 Cholinesterase BCHE 0.0438
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0429
465 Calmodulin CALM1 0.0414
136 Estrogen receptor ESR1 0.0408
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0404
629 Alpha-2B adrenergic receptor ADRA2B 0.0401
776 Bile salt export pump ABCB11 0.0369
696 Kappa-type opioid receptor OPRK1 0.0365
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.036
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0355
2164 Multidrug resistance-associated protein 4 ABCC4 0.0352
467 Delta-type opioid receptor OPRD1 0.0352
1636 Trace amine-associated receptor 1 TAAR1 0.0347
468 Cytochrome P450 4A11 CYP4A11 0.0331
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0331
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0329
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0329
378 Alpha-2C adrenergic receptor ADRA2C 0.0327
260 Cytochrome P450 51 ERG11 0.0324
761 Cytochrome P450 51 ERG11 0.0324
3163 Cytochrome P450 51 cyp51 0.0324
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0323
833 Organic cation/carnitine transporter 1 SLC22A4 0.0316
731 HIV-1 protease HIV-1 protease 0.0315
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0312
885 5-hydroxytryptamine 1B receptor HTR1B 0.0304
6014 Cytochrome P450 2A13 CYP2A13 0.0298
871 Glucocorticoid receptor NR3C1 0.0297
436 5-hydroxytryptamine 2B receptor HTR2B 0.0292
1757 Myeloperoxidase MPO 0.0291
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.029
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0283
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0281
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.028
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.028
6142 Solute carrier family 22 member 8 SLC22A8 0.0275
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0273
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.027
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.027
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0268
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0265
638 D(3) dopamine receptor DRD3 0.0262
891 Dihydropteroate synthase folP 0.026
5359 Dihydropteroate synthase folP 0.026
7175 Dihydropteroate synthase sulI 0.026
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0259
6031 Cytochrome P450 3A43 CYP3A43 0.0259
36 Insulin receptor INSR 0.0258
482 Glycine receptor subunit alpha-1 GLRA1 0.0255
6143 Solute carrier family 22 member 7 SLC22A7 0.0247
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0247
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0244
817 DNA topoisomerase 2-alpha TOP2A 0.0243
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0241
725 5-hydroxytryptamine 1D receptor HTR1D 0.024
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0239
1656 CYP2B protein CYP2B 0.0238
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0235
122 P2Y purinoceptor 12 P2RY12 0.0234
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0233
844 Epidermal growth factor receptor EGFR 0.0231
1517 Beta-3 adrenergic receptor ADRB3 0.023
474 Acetylcholinesterase ACHE 0.0228
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0227
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0218
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0216
6102 Arylamine N-acetyltransferase 2 NAT2 0.0214
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0208
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0206
6182 Cytochrome P450 2J2 CYP2J2 0.0202
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0199
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0197
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0197
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0193
432 D(4) dopamine receptor DRD4 0.0193
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0192
380 Cytochrome P450 17A1 CYP17A1 0.019
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0188
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0184
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0184
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0182
537 ATP synthase delta chain, mitochondrial ATP5D 0.0182
4120 NADPH--cytochrome P450 reductase POR 0.0181
16 Adenosine A1 receptor ADORA1 0.018
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0177
705 Glutamate receptor 1 GRIA1 0.0176
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0176
94 5-hydroxytryptamine 4 receptor HTR4 0.0174
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0174
811 Translocator protein TSPO 0.0173
6220 Aryl hydrocarbon receptor AHR 0.0167
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0167
477 DNA topoisomerase 4 subunit A parC 0.0165
886 DNA topoisomerase 4 subunit A parC 0.0165
6226 DNA topoisomerase 4 subunit A parC 0.0165
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0165
404 DNA gyrase subunit A gyrA 0.0163
6224 DNA gyrase subunit A gyrA 0.0163
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0163
6136 Multidrug resistance-associated protein 5 ABCC5 0.0162
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0161
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.016
504 Mast/stem cell growth factor receptor KIT 0.016
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0159
146 Androgen receptor AR 0.0158
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0158
1024 Solute carrier family 22 member 11 SLC22A11 0.0156
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0155
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0154
1178 Adenosine A2a receptor ADORA2A 0.0154
1010 Cytochrome P450 51A1 CYP51A1 0.0152
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0152
6432 Transporter snf 0.0151
869 Estrogen receptor beta ESR2 0.015
4604 Liver carboxylesterase 1 CES1 0.015
777 Tumor necrosis factor TNF 0.015
70 Type-1 angiotensin II receptor AGTR1 0.0149
716 5-hydroxytryptamine 7 receptor HTR7 0.0146
6141 Sodium/bile acid cotransporter SLC10A1 0.0142
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0141
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0139
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0138
1050 Bile salt sulfotransferase SULT2A1 0.0138
163 D(1B) dopamine receptor DRD5 0.0136
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0135
3810 Catechol O-methyltransferase COMT 0.0133
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0132
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0132
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0132
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0132
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0131
4116 Dihydropteroate synthetase Not Available 0.0131
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.013
3947 Xanthine dehydrogenase/oxidase XDH 0.013
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0129
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0129
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0129
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0129
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0128
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0127
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0127
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0126
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0126
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0125
124 Histamine H2 receptor HRH2 0.0125
232 Corticosteroid-binding globulin SERPINA6 0.0125
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0124
6148 Multidrug resistance-associated protein 7 ABCC10 0.0121
365 Dihydrofolate reductase DHFR 0.0121
2381 Dihydrofolate reductase DFR1 0.0121
2833 Dihydrofolate reductase Not Available 0.0121
2931 Dihydrofolate reductase folA 0.0121
3544 Dihydrofolate reductase folA 0.0121
3682 Dihydrofolate reductase folA 0.0121
6642 Dihydrofolate reductase folA 0.0121
6756 Dihydrofolate reductase dfrA 0.0121
818 50S ribosomal protein L10 rplJ 0.0121
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0121
442 Envelope glycoprotein gp41 0.012
4859 Envelope glycoprotein env 0.012
174 Sigma 1-type opioid receptor SIGMAR1 0.012
614 Progesterone receptor PGR 0.0119
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0118
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0118
921 Glutamate receptor 2 GRIA2 0.0117
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0115
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0115
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0115
295 Carbonic anhydrase 1 CA1 0.0115
251 Alcohol dehydrogenase 1A ADH1A 0.0114
6137 Multidrug resistance-associated protein 6 ABCC6 0.0114
275 Arachidonate 5-lipoxygenase ALOX5 0.0114
2230 Catalase CAT 0.0114
3249 Catalase katA 0.0114
3625 Catalase katA 0.0114
4539 Catalase katA 0.0114
4941 Catalase katB 0.0114
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.0113
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0112
4122 Histone deacetylase 2 HDAC2 0.0111
29 Tubulin beta-1 chain TUBB1 0.011
518 Peroxidase/catalase T katG 0.0109
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0109
444 Alcohol dehydrogenase 1B ADH1B 0.0108
3932 Glutathione S-transferase A2 GSTA2 0.0108
1618 High affinity nerve growth factor receptor NTRK1 0.0107
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0107
228 Beta platelet-derived growth factor receptor PDGFRB 0.0107
373 Transthyretin TTR 0.0107
613 Atrial natriuretic peptide receptor A NPR1 0.0106
407 Vascular endothelial growth factor receptor 2 KDR 0.0106
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0105
161 Tubulin beta chain TUBB 0.0105
312 Tubulin beta chain TUB2 0.0105
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0105
6020 Aldehyde oxidase AOX1 0.0105
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0104
563 Thyroid peroxidase TPO 0.0103
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0103
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0101
4237 50S ribosomal protein L22 rplV 0.01
1256 5-hydroxytryptamine 6 receptor HTR6 0.0098
183 Vascular endothelial growth factor A VEGFA 0.0097
958 Insulin-like growth factor 1 receptor IGF1R 0.0097
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0096
1192 Sulfotransferase 1A1 SULT1A1 0.0095
756 Sex hormone-binding globulin SHBG 0.0095
427 Substance-P receptor TACR1 0.0093
952 Dipeptidyl peptidase 4 DPP4 0.0093
592 Carbonic anhydrase 4 CA4 0.0093
153 Dopamine beta-hydroxylase DBH 0.0092
26 Vascular endothelial growth factor receptor 3 FLT4 0.0092
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0091
528 5-hydroxytryptamine 1E receptor HTR1E 0.0091
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.009
571 Melatonin receptor type 1A MTNR1A 0.009
362 Melatonin receptor type 1B MTNR1B 0.009
738 Monocarboxylate transporter 1 SLC16A1 0.0089
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0088
4238 50S ribosomal protein L4 rplD 0.0088
5578 50S ribosomal protein L4 rplD 0.0088
6173 50S ribosomal protein L4 rplD 0.0088
6219 50S ribosomal protein L4 rplD 0.0088
32 Vascular endothelial growth factor receptor 1 FLT1 0.0088
517 Alcohol dehydrogenase 1C ADH1C 0.0088
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0086
5787 Angiopoietin-1 receptor TEK 0.0086
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0085
88 Retinoic acid receptor RXR-beta RXRB 0.0084
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0084
904 Glutathione S-transferase P GSTP1 0.0083
84 Nuclear receptor 0B1 NR0B1 0.0081
565 Extracellular calcium-sensing receptor CASR 0.008
606 Cytochrome P450 27, mitochondrial CYP27A1 0.008
2981 Phospholipase A2, membrane associated PLA2G2A 0.008
284 DNA-directed RNA polymerase beta chain rpoB 0.0079
5773 DNA-directed RNA polymerase beta chain rpoB 0.0079
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0079
173 Toll-like receptor 7 TLR7 0.0079
1275 Estrogen sulfotransferase SULT1E1 0.0078
6138 Multidrug resistance protein 3 ABCB4 0.0077
1360 Sphingomyelin phosphodiesterase SMPD1 0.0077
6085 Fatty acid-binding protein, intestinal FABP2 0.0077
68 Cannabinoid receptor 1 CNR1 0.0075
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0075
737 Mineralocorticoid receptor NR3C2 0.0074
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0074
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0074
1541 Metalloproteinase mmp20 0.0074
814 Ryanodine receptor 1 RYR1 0.0074
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0073
4148 Serine/threonine-protein kinase mTOR MTOR 0.0073
2183 Fatty acid-binding protein, adipocyte FABP4 0.0072
511 5-hydroxytryptamine 1F receptor HTR1F 0.0071
790 DNA polymerase subunit alpha B POLA2 0.0071
24 Thymidylate synthase TMP1 0.0071
359 Thymidylate synthase TYMS 0.0071
2626 Thymidylate synthase thyA 0.0071
2729 Thymidylate synthase thyA 0.0071
5352 Thymidylate synthase THYA 0.0071
3809 Estrogen-related receptor gamma ESRRG 0.0071
4203 Histamine N-methyltransferase HNMT 0.0071
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0071
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0071
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0071
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0071
6126 Carbonic anhydrase 7 CA7 0.007
357 Carbonic anhydrase 2 CA2 0.0069
49 Endothelin B receptor EDNRB 0.0069
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0069
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0069
780 Retinoic acid receptor RXR-gamma RXRG 0.0069
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0069
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0069
768 FK506-binding protein 1A FKBP1A 0.0068
1629 Transcription factor AP-1 JUN 0.0068
823 Fibroblast growth factor receptor 2 FGFR2 0.0068
2112 Toll-like receptor 9 TLR9 0.0068
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0067
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0067
3937 Fatty-acid amide hydrolase FAAH 0.0066
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0066
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0066
578 Endothelin-1 receptor EDNRA 0.0065
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0065
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0065
856 Vitamin D3 receptor VDR 0.0064
828 Phenylalanine-4-hydroxylase PAH 0.0064
3109 Phenylalanine-4-hydroxylase phhA 0.0064
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0064
1648 Elastin ELN 0.0063
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0063
3917 Methylenetetrahydrofolate reductase MTHFR 0.0063
133 Dihydropterate synthase sulI 0.0063
6174 50S ribosomal protein L32 rpmF 0.0062
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0062
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0062
2298 Cytochrome P450-cam camC 0.0061
7 Nitric oxide synthase, inducible NOS2 0.0061
273 Apoptosis regulator Bcl-2 BCL2 0.0061
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.006
751 Potassium channel subfamily K member 6 KCNK6 0.006
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.006
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0059
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0059
162 Retinoic acid receptor gamma-1 RARG 0.0059
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0059
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0058
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0058
5880 Thrombopoietin receptor MPL 0.0058
208 DNA-directed RNA polymerase beta' chain rpoC 0.0058
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0058
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0058
6146 High affinity copper uptake protein 1 SLC31A1 0.0058
634 Squalene monooxygenase SQLE 0.0056
7196 Squalene monooxygenase ERG1 0.0056
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0056
319 Opioid receptor, sigma 1 OPRS1 0.0056
581 Cytochrome P450 2R1 CYP2R1 0.0056
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0055
172 Potassium channel subfamily K member 1 KCNK1 0.0055
6506 Stathmin-4 STMN4 0.0055
469 Annexin A1 ANXA1 0.0054
390 Adenosine A3 receptor ADORA3 0.0053
4311 tRNA TRDMT1 0.0053
4325 tRNA trmD 0.0053
4328 tRNA trmD 0.0053
5998 Toll-like receptor 8 TLR8 0.0053
239 Coagulation factor X F10 0.0052
54 Prothrombin F2 0.0052
712 Tubulin alpha chain TUB1 0.0052
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0052
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0051
3823 Cytokine receptor common gamma chain IL2RG 0.0051
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0051
6044 Serum paraoxonase/lactonase 3 PON3 0.005
6766 O-GlcNAcase BT_4395 BT_4395 0.0049
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0049
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0049
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0049
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0049
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0049
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0049
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0049
3404 Exotoxin A eta 0.0049
164 Histamine H4 receptor HRH4 0.0048
106 Cannabinoid receptor 2 CNR2 0.0048
976 Platelet glycoprotein IX GP9 0.0048
1483 Membrane copper amine oxidase AOC3 0.0048
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0048
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0047
908 Glutathione S-transferase theta-1 GSTT1 0.0047
723 Cytosolic phospholipase A2 PLA2G4A 0.0047
4228 Keratin, type II cytoskeletal 7 KRT7 0.0046
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0046
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0046
719 Retinoic acid receptor responder protein 1 RARRES1 0.0045
165 FL cytokine receptor FLT3 0.0045
770 Retinoic acid-induced protein 3 GPRC5A 0.0045
992 Protein tyrosine kinase 2 beta PTK2B 0.0045
527 Prostacyclin receptor PTGIR 0.0045
3086 Plasmepsin-2 Not Available 0.0045
3856 Fibroblast growth factor receptor 3 FGFR3 0.0045
3957 Adenosine deaminase ADA 0.0045
5934 Cytochrome P450 26A1 CYP26A1 0.0045
724 Interleukin-2 receptor alpha chain IL2RA 0.0045
717 Interleukin-2 receptor subunit beta IL2RB 0.0045
2178 Metabotropic glutamate receptor 5 GRM5 0.0045
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0045
6043 Putative G-protein coupled receptor 44 GPR44 0.0044
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0044
3639 Thymidine phosphorylase deoA 0.0044
3936 Thymidine phosphorylase TYMP 0.0044
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0044
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0044
1268 Neuropeptide S receptor NPSR1 0.0044
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0044
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0044
130 Prostacyclin synthase PTGIS 0.0044
1262 Corticotropin-lipotropin POMC 0.0044
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0043
1992 Vitamin D-binding protein GC 0.0043
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0043
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0043
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0043
4226 Uridine phosphorylase 2 UPP2 0.0043
473 L-lactate dehydrogenase A chain LDHA 0.0042
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0042
714 Glutathione reductase, mitochondrial GSR 0.0042
1864 RET proto-oncogene RET 0.0041
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0041
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0041
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0041
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0041
2449 Tubulin alpha-3 chain TUBA1A 0.0041
459 Retinoic acid receptor RXR-alpha RXRA 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
3808 Dihydropteroate synthase 2 folP2 0.0041
3601 Dihydropteroate synthase 1 folP1 0.0041
3807 Dihydropteroate synthase 1 folP1 0.0041
400 Coagulation factor IX F9 0.004
5461 Coagulation factor IX F9 0.004
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.004
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.004
1630 Integrin beta-2 ITGB2 0.004
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.004
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.004
268 Adenosine A2b receptor ADORA2B 0.004
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.004
569 Retinal dehydrogenase 2 ALDH1A2 0.004
6073 Potassium channel subfamily K member 9 KCNK9 0.004
6072 Potassium channel subfamily K member 3 KCNK3 0.004
1039 Histone deacetylase 9 HDAC9 0.004
4225 Uridine phosphorylase 1 UPP1 0.0039
4217 Telomerase reverse transcriptase TERT 0.0039
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0039
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0039
2290 ADP-ribosyl cyclase 2 BST1 0.0039
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0038
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0038
4164 Potassium voltage-gated channel subfamily KQT member 5 KCNQ5 0.0038
4163 Potassium voltage-gated channel subfamily KQT member 4 KCNQ4 0.0038
605 Fumarate reductase flavoprotein subunit frdA 0.0038
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0038
3673 Fumarate reductase flavoprotein subunit fccA 0.0038
4912 Fumarate reductase flavoprotein subunit ifcA 0.0038
6549 Fumarate reductase flavoprotein subunit frdA 0.0038
1374 Natriuretic peptides B NPPB 0.0038
2207 Rhodopsin RHO 0.0038
820 Glycine receptor subunit alpha-2 GLRA2 0.0037
1827 Gap junction alpha-1 protein GJA1 0.0037
1908 Vascular cell adhesion protein 1 VCAM1 0.0037
611 Retinal dehydrogenase 1 ALDH1A1 0.0037
6103 Arylamine N-acetyltransferase 1 NAT1 0.0037
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0037
604 Vitamin K-dependent protein Z PROZ 0.0037
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0037
413 Amidophosphoribosyltransferase PPAT 0.0037
2515 Amidophosphoribosyltransferase purF 0.0037
3714 Amidophosphoribosyltransferase purF 0.0037
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0036
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0036
558 Solute carrier family 12 member 1 SLC12A1 0.0036
543 Penicillin-binding protein 1B mrcB 0.0035
6186 Penicillin-binding protein 1B ponB 0.0035
6822 Penicillin-binding protein 1b pbp1b 0.0035
6844 Penicillin-binding protein 1b pbp1b 0.0035
185 Vasopressin V1a receptor AVPR1A 0.0035
117 Sterol O-acyltransferase 1 SOAT1 0.0035
2539 Tubulin alpha-1 chain TUBA4A 0.0035
159 Penicillin-binding protein 2B penA 0.0035
6121 Penicillin-binding protein 2B penA 0.0035
939 50S ribosomal protein L3 rplC 0.0035
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0035
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0035
4103 Proteasome subunit beta type 2 PSMB2 0.0034
291 Nitric-oxide synthase, endothelial NOS3 0.0034
4102 Proteasome subunit beta type 5 PSMB5 0.0034
4101 Proteasome subunit beta type 1 PSMB1 0.0034
322 Vasopressin V2 receptor AVPR2 0.0034
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0034
2499 Tubulin beta-2C chain TUBB2C 0.0034
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0034
1245 Vitamin K-dependent protein S PROS1 0.0034
422 Vitamin K-dependent protein C PROC 0.0034
5300 Antigen peptide transporter 1 TAP1 0.0034
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0033
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0033
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0033
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0033
229 Retinoic acid receptor beta RARB 0.0033
730 Retinoic acid receptor alpha RARA 0.0032
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0032
4192 DNA topoisomerase 2-beta TOP2B 0.0032
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0032
3090 Chitosanase csn 0.0031
4149 Nuclear factor NF-kappa-B p100 subunit NFKB2 0.0031
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0031
1196 Complement decay-accelerating factor CD55 0.0031
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0031
1227 Cytochrome b MT-CYB 0.0031
6386 Cytochrome b petB 0.0031
6937 Cytochrome b MT-CYB 0.0031
674 Dihydroorotate dehydrogenase homolog, mitochondrial PFF0160c 0.0031
65 Matrix metalloproteinase-9 Not Available 0.0031
2320 Thymidine kinase, cytosolic TK1 0.003
2578 Tubulin beta-3 chain TUBB3 0.003
3913 Glutamic acid decarboxylase GAD65 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
448 Vitamin K-dependent gamma-carboxylase GGCX 0.003
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.003
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.003
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.003
896 Glutathione S-transferase Mu 1 GSTM1 0.0029
936 Ephrin type-A receptor 2 EPHA2 0.0029
512 DNA-directed RNA polymerase alpha chain rpoA 0.0029
5772 DNA-directed RNA polymerase alpha chain rpoA 0.0029
1253 Interferon gamma IFNG 0.0028
330 Spermidine synthase SRM 0.0028
3038 Spermidine synthase speE 0.0028
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0028
1200 AMBP protein AMBP 0.0028
3866 Serum amyloid A protein SAA1 0.0028
1932 Apolipoprotein E APOE 0.0028
798 Osteocalcin BGLAP 0.0028
1852 Microtubule-associated protein 2 MAP2 0.0028
6151 Monocarboxylate transporter 10 SLC16A10 0.0028
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0027
2808 Chloramphenicol acetyltransferase 3 cat3 0.0027
1144 Hepatocyte growth factor receptor MET 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
2159 Quinone oxidoreductase CRYZ 0.0027
6163 Copper-transporting ATPase 2 ATP7B 0.0027
6165 Copper-transporting ATPase 1 ATP7A 0.0027
33 Cystine/glutamate transporter SLC7A11 0.0027
358 Cystathionine beta-synthase CBS 0.0027
3849 Insulin-like growth factor-binding protein 7 IGFBP7 0.0027
2009 Protein NOV homolog NOV 0.0027
3847 Neuroendocrine convertase 2 PCSK2 0.0027
1949 Carboxypeptidase E CPE 0.0027
3850 Synaptotagmin-like protein 4 SYTL4 0.0027
3848 Neuroendocrine convertase 1 PCSK1 0.0027
3846 Retinoblastoma-associated protein RB1 0.0027
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0027
6149 Solute carrier family 22 member 10 SLC22A10 0.0026
5798 Mitogen-activated protein kinase 11 MAPK11 0.0026
735 Alanine aminotransferase 1 GPT 0.0025
3904 Alanine aminotransferase 2 GPT2 0.0025
6033 High affinity interleukin-8 receptor A CXCR1 0.0025
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0025
267 Plasminogen activator inhibitor 1 SERPINE1 0.0025
369 Coagulation factor VII F7 0.0025
2417 Chloramphenicol acetyltransferase cat 0.0025
3278 Chloramphenicol acetyltransferase cat 0.0025
2810 Dr hemagglutinin structural subunit draA 0.0025
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0025
334 S-adenosylmethionine synthetase isoform type-2 MAT2A 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
6070 Nischarin NISCH 0.0024
233 Potassium channel subfamily K member 2 KCNK2 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
4773 Deoxycytidine kinase DCK 0.0024
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0023
6048 Troponin C, skeletal muscle TNNC2 0.0023
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0023
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0023
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0023
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0023
1830 5'-nucleotidase NT5E 0.0023
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.0023
1353 DNA topoisomerase 1 TOP1 0.0023
3552 DNA topoisomerase 1 topA 0.0023
1341 Histamine H3 receptor HRH3 0.0023
6221 Steroid hormone receptor ERR1 ESRRA 0.0023
113 S-adenosylmethionine decarboxylase proenzyme AMD1 0.0022
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0022
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0022
411 Glycine N-methyltransferase GNMT 0.0022
2155 Insulin-degrading enzyme IDE 0.0022
2232 Interleukin-5 IL5 0.0022
6824 Tyrosine-protein kinase Lyn LYN 0.0021
298 Renin REN 0.0021
1593 Mucin-2 MUC2 0.0021
2091 Endoplasmin HSP90B1 0.0021
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.0021
63 Malate dehydrogenase mdh 0.0021
2329 Malate dehydrogenase mdh 0.0021
3445 Malate dehydrogenase mdh 0.0021
4420 Malate dehydrogenase mdh 0.0021
4438 Malate dehydrogenase mdh 0.0021
572 Integrin alpha-L ITGAL 0.0021
3868 Calcineurin subunit B isoform 2 PPP3R2 0.002
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.002
594 Thyroxine-binding globulin SERPINA7 0.002
3611 Cytidine deaminase cdd 0.002
3707 Cytidine deaminase cdd 0.002
4211 Cytidine deaminase CDA 0.002
1820 Beta-nerve growth factor NGF 0.002
2236 Casein kinase II subunit alpha CSNK2A1 0.0019
633 Penicillin-binding proteins 1A/1B pbpA 0.0019
5923 Microtubule-associated protein tau MAPT 0.0019
5924 Microtubule-associated protein 4 MAP4 0.0019
2216 Fibroblast growth factor receptor 4 FGFR4 0.0019
1291 cAMP response element-binding protein CREB1 0.0019
718 Folate receptor gamma FOLR3 0.0019
299 Folate receptor beta FOLR2 0.0019
804 Mitochondrial folate transporter/carrier SLC25A32 0.0019
760 Fibroblast growth factor 1 FGF1 0.0019
6131 Carbonic anhydrase 14 CA14 0.0019
758 Thyroid hormone receptor alpha THRA 0.0019
893 [Citrate [pro-3S]-lyase] ligase citC 0.0018
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0018
4210 Toll-like receptor 4 TLR4 0.0018
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0018
3221 Cytochrome c4 cc4 0.0018
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
327 Glutathione reductase gor 0.0018
5110 Glutathione reductase GR2 0.0018
683 Potassium transporter GK0582 0.0018
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0018
6122 Carbonic anhydrase 3 CA3 0.0018
1123 Eosinophil cationic protein RNASE3 0.0018
6459 Glycodelin PAEP 0.0018
199 Monocarboxylate transporter 8 SLC16A2 0.0018
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0017
293 Gamma-glutamyl hydrolase GGH 0.0017
346 Thyroid hormone receptor beta-1 THRB 0.0017
144 Hemoglobin subunit alpha HBA1 0.0016
1243 Cathepsin D CTSD 0.0016
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0016
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0016
3830 Calreticulin CALR 0.0016
3233 Bile acid receptor NR1H4 0.0015
2853 14 kDa fatty acid-binding protein Not Available 0.0015
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0015
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0015
1714 Mitogen-activated protein kinase 3 MAPK3 0.0015
6034 Hydroxyindole O-methyltransferase ASMT 0.0015
3844 HLA class II histocompatibility antigen, DQ(6) alpha chain HLA-DQA2 0.0015
6035 Nuclear receptor ROR-beta RORB 0.0015
6036 Eosinophil peroxidase EPX 0.0015
1650 Heme carrier protein 1 SLC46A1 0.0015
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0015
489 Monocarboxylate transporter 2 SLC16A7 0.0014
6167 Organic solute transporter subunit beta OSTB 0.0014
6166 Organic solute transporter subunit alpha OSTA 0.0014
2599 Tyrosine-protein kinase HCK HCK 0.0014
6218 Pannexin-1 PANX1 0.0014
6859 Protein S100-A4 S100A4 0.0014
2021 Thrombomodulin THBD 0.0013
244 Angiotensin-converting enzyme ACE 0.0013
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0013
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0013
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0013
6211 Tubulin epsilon chain TUBE1 0.0013
6212 Tubulin gamma-1 chain TUBG1 0.0013
6210 Tubulin delta chain TUBD1 0.0013
6168 Solute carrier family 22 member 16 SLC22A16 0.0013
765 Indoleamine 2,3-dioxygenase IDO1 0.0013
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0013
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0013
860 Nicotinamide N-methyltransferase NNMT 0.0013
5626 Nucleoside diphosphate kinase B NME2 0.0013
699 Nicotinic acid receptor 1 GPR109A 0.0013
928 Nicotinic acid receptor 2 GPR109B 0.0013
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0013
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
85 Growth hormone receptor GHR 0.0012
2107 Microtubule-associated protein 1A MAP1A 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
4948 Cytochrome c-553 Not Available 0.0012
4923 Cytochrome c3 DvMF_2499 0.0012
4945 Cytochrome c3 Not Available 0.0012
4949 Cytochrome c3 DVU_3171 0.0012
4968 Cytochrome c3 cytc3 0.0012
4997 Cytochrome c3 SO_2727 0.0012
5219 Cytochrome c3 cyd 0.0012
1295 Fatty acid synthase FASN 0.0012
4902 Nine-heme cytochrome c Ddes_2038 0.0012
3189 High-molecular-weight cytochrome c hmcA 0.0012
5433 UPF0230 protein TM_1468 TM_1468 0.0012
5431 Lipid binding protein Not Available 0.0012
3616 Fatty acid-binding protein, epidermal FABP5 0.0012
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0012
76 Nitric-oxide synthase, brain NOS1 0.0012
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0011
1063 Signal transducer and activator of transcription 5B STAT5B 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
707 72 kDa type IV collagenase MMP2 0.0011
2300 Lysozyme E 0.001
3633 Lysozyme R 0.001
5597 Lysozyme 17 0.001
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.001
3238 Multidrug resistance protein mexA mexA 0.001
3709 Glycerol uptake facilitator protein glpF 0.001
3116 Bacterioferritin bfr 0.001
4906 Bacterioferritin bfr 0.001
4965 Bacterioferritin bfr 0.001
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.001
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.001
3173 Enolase eno 0.001
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.001
3393 TGF-beta receptor type-2 TGFBR2 0.001
4386 Hemoglobin-like protein HbN glbN 0.001
3007 Carbonic anhydrase 12 CA12 0.001
4205 Carbonic anhydrase 9 CA9 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
5294 Nucleoside diphosphate kinase A NME1 0.001
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.001
283 SEC14-like protein 2 SEC14L2 0.001
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
6837 Serine/threonine-protein kinase 17B STK17B 0.001
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.001
2268 Cholesterol oxidase choB 0.0009
2822 Cholesterol oxidase choA 0.0009
997 Protein kinase C beta type PRKCB 0.0009
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0009
2211 Fatty acid-binding protein, heart FABP3 0.0009
484 Tyrosine-protein kinase ABL2 ABL2 0.0009
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0009
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0009
1792 Tissue-type plasminogen activator PLAT 0.0009
1048 Protein S100-A13 S100A13 0.0009
2226 Protein S100-A12 S100A12 0.0009
2852 DNA mismatch repair protein mutL mutL 0.0009
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0009
1770 Phospholipase C PLCL1 0.0009
2841 Phospholipase C plc 0.0009
6677 Myelin P2 protein PMP2 0.0009
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0009
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0009
2283 Steroid Delta-isomerase ksi 0.0009
2920 Steroid Delta-isomerase ksi 0.0009
3191 Histidinol dehydrogenase hisD 0.0009
1970 Protein kinase C alpha type PRKCA 0.0009
2132 Protein S100-B S100B 0.0009
2408 Tyrosine-protein kinase SYK SYK 0.0009
740 Argininosuccinate synthase ASS1 0.0009
865 Argininosuccinate synthase ASS1 0.0009
2680 Argininosuccinate synthase argG 0.0009
3194 Argininosuccinate synthase argG 0.0009
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0008
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0008
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0008
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0008
4692 A/G-specific adenine glycosylase mutY 0.0008
4954 Soluble cytochrome b558 Not Available 0.0008
4925 Cytochrome c-type protein SHP shp 0.0008
4916 Cyanoglobin glbN 0.0008
4947 Bacterial hemoglobin vhb 0.0008
4915 Cytochrome c-550 psbV 0.0008
4959 Cytochrome c-550 psbV 0.0008
5216 Cytochrome c-550 psbV 0.0008
4934 Cytochrome c-551 nirM 0.0008
5218 Cytochrome c-551 nirM 0.0008
4943 Cytochrome c6 petJ 0.0008
4975 Cytochrome c-556 RPA3973 0.0008
4936 Cytochrome c2 iso-2 Not Available 0.0008
4994 Hemoglobin-like protein HbO glbO 0.0008
4905 Cytochrome c2 Not Available 0.0008
4939 Cytochrome c2 cycA 0.0008
4964 Cytochrome c2 cycA 0.0008
4979 Cytochrome c2 cycA 0.0008
6673 Cytochrome c2 cycA 0.0008
4984 Neuroglobin NGB 0.0008
4998 Hemoglobin-like protein yjbI yjbI 0.0008
5000 HemO hemO 0.0008
4910 Cytoglobin CYGB 0.0008
4909 CooA protein cooA 0.0008
4981 Iron-starvation protein PigA pigA 0.0008
4907 Cytochrome c-L moxG 0.0008
6865 Cytochrome c-L moxG 0.0008
644 Heme oxygenase 2 HMOX2 0.0008
4982 Heme oxygenase 2 pbsA2 0.0008
4942 Diheme cytochrome c napB napB 0.0008
4935 Cytochrome c-554 cycA1 0.0008
4961 Hemophore HasA hasA 0.0008
4904 Cytochrome c family protein GSU1996 0.0008
4971 Nonaheme cytochrome c hmcA 0.0008
4976 Apocytochrome f petA 0.0008
6407 Apocytochrome f petA 0.0008
4764 Cytochrome P450 165C4 CYP165C4 0.0008
4999 Cytochrome P450 165B3 CYP165B3 0.0008
4960 Putative cytochrome P450-family protein SCO7417 0.0008
4931 Cytochrome P450 167A1 CYP167A1 0.0008
4989 Cytochrome c551 peroxidase ccp 0.0008
5222 Cytochrome c551 peroxidase ccpA 0.0008
4937 Cytochrome oxidase subunit II rcoxA 0.0008
4972 P450cin cinA 0.0008
4903 Methyl-accepting chemotaxis protein Tar4 0.0008
4926 Heme-based aerotactic transducer hemAT hemAT 0.0008
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0008
4922 Cytochrome c, putative SO_4144 0.0008
4993 Hydroxylamine oxidoreductase hao1 0.0008
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0008
3093 Catalase HPII katE 0.0008
4952 Catalase/peroxidase katA 0.0008
1867 Major prion protein PRNP 0.0008
1507 Cytochrome c CYCS 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
6599 HTH-type transcriptional regulator ttgR ttgR 0.0008
500 Monocarboxylate transporter 4 SLC16A3 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
1025 Aquaporin-1 AQP1 0.0008
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0007
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0007
461 Glycine receptor subunit alpha-3 GLRA3 0.0007
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0007
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0007
2802 Endoglucanase G celCCG 0.0007
822 Aldose reductase AKR1B1 0.0007
6316 ADP-ribosylation factor 1 ARF1 0.0007
6228 Nuclear receptor coactivator 1 NCOA1 0.0007
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0007
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0007
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0007
6207 30S ribosomal protein S14 rpsN 0.0007
6209 30S ribosomal protein S19 rpsS 0.0007
6712 30S ribosomal protein S19 rpsS 0.0007
6726 30S ribosomal protein S19 rpsS 0.0007
6241 Nuclear receptor coactivator 2 NCOA2 0.0007
645 Penicillin-binding protein 1A mrcA 0.0007
5805 Penicillin-binding protein 1A ponA 0.0007
6185 Penicillin-binding protein 1A mrcA 0.0007
6799 Penicillin-binding protein 1A pbpA 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
125 DNA polymerase beta POLB 0.0007
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0007
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0007
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0006
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0006
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0006
3426 Glutamine synthetase glnA 0.0006
3987 Glutamine synthetase GLUL 0.0006
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0006
4920 Peroxidase/catalase katG 0.0006
2119 Cytochrome b5 CYB5A 0.0006
4990 PpcA ppcA 0.0006
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0006
3375 Acidic cytochrome c3 Not Available 0.0006
4988 Sulfite oxidase, mitochondrial SUOX 0.0006
2915 Sensor protein fixL fixL 0.0006
4944 Sensor protein fixL fixL 0.0006
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0006
4385 Cytochrome c' Not Available 0.0006
4967 Cytochrome c' cycA 0.0006
5038 Cytochrome c' Not Available 0.0006
5223 Cytochrome c' cycP 0.0006
3570 Cytochrome P450 152A1 cypC 0.0006
4813 Heme oxygenase hmuO 0.0006
5769 Heme oxygenase Not Available 0.0006
4037 Hypothetical protein GPX1 0.0006
4297 Hypothetical protein SP_1951 0.0006
4521 Hypothetical protein BC_2969 0.0006
4540 Hypothetical protein TM_1070 0.0006
4555 Hypothetical protein MT1739 0.0006
4569 Hypothetical protein mshD 0.0006
4578 Hypothetical protein PA3270 0.0006
4747 Hypothetical protein PA3967 0.0006
5177 Hypothetical protein TM_0096 0.0006
5194 Hypothetical protein PA1204 0.0006
5240 Hypothetical protein Rv2991 0.0006
5370 Hypothetical protein TM_1158 0.0006
5710 Hypothetical protein Tb927.5.1360 0.0006
4289 Cytochrome P450 TT_P0059 0.0006
6262 Cytochrome P450 staP 0.0006
4992 Cytochrome c peroxidase Not Available 0.0006
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0006
1569 G1/S-specific cyclin-D1 CCND1 0.0006
1525 Heparin-binding growth factor 2 FGF2 0.0006
5221 Cytochrome c3, 13 kDa Not Available 0.0006
3152 Cytochrome c'' cycA 0.0006
5220 Split-Soret cytochrome c Ddes_2150 0.0006
3700 Cytochrome c-552 precursor nrfA 0.0006
1760 Aminopeptidase N ANPEP 0.0005
6843 Aminopeptidase N pepN 0.0005
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0005
3411 Cytochrome P450 121 cyp121 0.0005
3670 Soluble cytochrome b562 precursor cybC 0.0005
3291 Cytochrome c-552 cycA 0.0005
4927 Cytochrome c-552 nrfA 0.0005
4938 Cytochrome c-552 cycA 0.0005
4953 Cytochrome c-552 nrfA 0.0005
5217 Cytochrome c-552 cycM 0.0005
2617 Nitric oxide synthase oxygenase nos 0.0005
2701 Nitric oxide synthase oxygenase nos 0.0005
3102 Flavohemoprotein hmp 0.0005
4969 Flavohemoprotein hmp 0.0005
3127 Nitrite reductase nirS 0.0005
3284 Nitrite reductase nirS 0.0005
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0005
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0005
2972 6-deoxyerythronolide B hydroxylase eryF 0.0005
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0004
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0004
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0004
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0004
4608 Putative cytochrome P450 SCO1207 0.0004
4963 Putative cytochrome P450 SCO2884 0.0004
6254 Putative cytochrome P450 SCO6998 0.0004
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0004
3405 Quinohaemoprotein ethanol dehydrogenase type-1 qheDH 0.0004
6042 Prostaglandin reductase 2 PTGR2 0.0004
693 Hemoglobin subunit beta HBB 0.0004
1176 Mitogen-activated protein kinase 1 MAPK1 0.0004
6268 Hydroxyacid oxidase 1 HAO1 0.0004
810 Heme oxygenase 1 HMOX1 0.0004
3391 Heme oxygenase 1 pbsA1 0.0004
2240 Cell division protein kinase 2 CDK2 0.0003
1313 Lactoylglutathione lyase GLO1 0.0003
6135 Sodium channel subunit beta-4 SCN4B 0.0002
6134 Sodium channel subunit beta-3 SCN3B 0.0002
6132 Sodium channel subunit beta-1 SCN1B 0.0002
6127 Carbonic anhydrase-related protein CA8 0.0002
6128 Carbonic anhydrase-related protein 10 CA10 0.0002
6133 Sodium channel subunit beta-2 SCN2B 0.0002
6129 Carbonic anhydrase-related protein 11 CA11 0.0002
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0002
6130 Carbonic anhydrase 13 CA13 0.0002
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