DT-Web

DB00317 - Gefitinib


Identification
Name Gefitinib
Accession Number DB00317 (APRD00997, DB07998)
Type small molecule
Description Gefitinib (originally coded ZD1839) is a drug used in the treatment of certain types of cancer. Acting in a similar manner to erlotinib (marketed as Tarceva), gefitinib selectively targets the mutant proteins in malignant cells. It is marketed by AstraZeneca under the trade name Iressa. [Wikipedia]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 446.902
Groups approved
Monoisotopic Weight 446.152096566
Pharmacology
Indication For the continued treatment of patients with locally advanced or metastatic non-small cell lung cancer after failure of either platinum-based or docetaxel chemotherapies.
Mechanism of action Gefitinib inhibits the epidermal growth factor receptor (EGFR) tyrosine kinase by binding to the adenosine triphosphate (ATP)-binding site of the enzyme. Thus the function of the EGFR tyrosine kinase in activating the Ras signal transduction cascade is inhibited; and malignant cells are inhibited. Gefitinib is the first selective inhibitor of the EGFR tyrosine kinase which is also referred to as Her1 or ErbB-1. EGFR is overexpressed in the cells of certain types of human carcinomas - for example in lung and breast cancers. Overexpression leads to inappropriate activation of the apoptotic Ras signal transduction cascade, eventually leading to uncontrolled cell proliferation.
Absorption Absorbed slowly after oral administration with a mean bioavailability of 60%. Peak plasma levels occurs 3-7 hours post-administration. Food does not affect the bioavailability of gefitinib.
Protein binding 90% primarily to serum albumin and alpha 1-acid glycoproteins (independent of drug concentrations).
Biotransformation Primarily hepatic via CYP3A4. Three sites of biotransformation have been identified: metabolism of the N-propoxymorpholino-group, demethylation of the methoxy-substituent on the quinazoline, and oxidative defluorination of the halogenated phenyl group.
Route of elimination Elimination is by metabolism (primarily CYP3A4) and excretion in feces. Excretion is predominantly via the feces (86%), with renal elimination of drug and metabolites accounting for less than 4% of the administered dose.
Toxicity The acute toxicity of gefitinib up to 500 mg in clinical studies has been low. In non-clinical studies, a single dose of 12,000 mg/m2 (about 80 times the recommended clinical dose on a mg/m2 basis) was lethal to rats. Half this dose caused no mortality in mice. Symptoms of overdose include diarrhea and skin rash.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Acenocoumarol Gefitinib may increase the anticoagulant effect of acenocoumarol.
Amobarbital The CYP3A4 inducer, amobarbital, may decrease the serum concentration and therapeutic effects of gefitinib.
Anisindione Gefitinib may increase the anticoagulant effect of anisindione.
Aprobarbital The CYP3A4 inducer, aprobarbital, may decrease the serum concentration and therapeutic effects of gefitinib.
Butabarbital The CYP3A4 inducer, butabarbital, may decrease the serum concentration and therapeutic effects of gefitinib.
Butalbital The CYP3A4 inducer, butalbital, may decrease the serum concentration and therapeutic effects of gefitinib.
Butethal The CYP3A4 inducer, butethal, may decrease the serum concentration and therapeutic effects of gefitinib.
Carbamazepine The CYP3A4 inducer, carbamazepine, may decrease the serum concentration and therapeutic effects of gefitinib.
Clarithromycin This CYP3A4 inhibitor increases levels/toxicity of gefitinib
Dicumarol Gefitinib may increase the anticoagulant effect of dicumarol.
Dihydroquinidine barbiturate The CYP3A4 inducer, dihydroquinidine barbiturate, may decrease the serum concentration and therapeutic effects of gefitinib.
Erythromycin This CYP3A4 inhibitor increases levels/toxicity of gefitinib
Ethotoin The CYP3A4 inducer, ethotoin, may decrease the serum concentration and therapeutic effects of gefitinib.
Etravirine Gefitinib, when administered concomitantly with etravirine (a strong CYP3A4 inducer), may experience a decrease in serum concentration. It is recommended to increase gefitinib dosage, if clinically appropriate, and to monitor for gefitinib therapy for efficacy and toxicity.
Fosphenytoin The CYP3A4 inducer, fosphenytoin, may decrease the serum concentration and therapeutic effects of gefitinib.
Heptabarbital The CYP3A4 inducer, heptabarbital, may decrease the serum concentration and therapeutic effects of gefitinib.
Hexobarbital The CYP3A4 inducer, hexobarbital, may decrease the serum concentration and therapeutic effects of gefitinib.
Itraconazole Itraconazole, a strong CYP3A4 inhibitor, may decrease the metabolism of gefitinib. Monitor for changes in the therapeutic and adverse effects of gefitinib if itraconazole is initiated, discontinued or dose changed.
Ketoconazole This CYP3A4 inhibitor increases levels/toxicity of gefitinib
Mephenytoin The CYP3A4 inducer, mephenytoin, may decrease the serum concentration and therapeutic effects of gefitinib.
Methohexital The CYP3A4 inducer, methohexital, may decrease the serum concentration and therapeutic effects of gefitinib.
Methylphenobarbital The CYP3A4 inducer, methylphenobarbital, may decrease the serum concentration and therapeutic effects of gefitinib.
Pentobarbital The CYP3A4 inducer, pentobarbital, may decrease the serum concentration and therapeutic effects of gefitinib.
Phenobarbital The CYP3A4 inducer, phenobarbital, may decrease the serum concentration and therapeutic effects of gefitinib.
Phenytoin The CYP3A4 inducer, phenytoin, may decrease the serum concentration and therapeutic effects of gefitinib.
Primidone The CYP3A4 inducer, primidone, may decrease the serum concentration and therapeutic effects of gefitinib.
Quinidine barbiturate The CYP3A4 inducer, quinidine barbiturate, may decrease the serum concentration and therapeutic effects of gefitinib.
Rifampin Rifampin reduces levels and efficacy of gefitinib
Ritonavir This CYP3A4 inhibitor increases levels/toxicity of gefitinib
Secobarbital The CYP3A4 inducer, secobarbital, may decrease the serum concentration and therapeutic effects of gefitinib.
St. John's Wort The CYP3A4 inducer, St. John's Wort, may decrease the serum concentration and therapeutic effects of gefitinib.
Talbutal The CYP3A4 inducer, talbutal, may decrease the serum concentration and therapeutic effects of gefitinib.
Telithromycin Telithromycin may reduce clearance of Gefitinib. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Gefitinib if Telithromycin is initiated, discontinued or dose changed.
Topotecan The BCRP/ABCG2 inhibitor, Gefitnib, may increase the bioavailability and serum concentration of oral Topotecan. Monitor for change in the therapeutic and adverse effects of Topotecan if Gefitinib is initiated, discontinued or dose changed.
Trastuzumab Trastuzumab may increase the risk of neutropenia and anemia. Monitor closely for signs and symptoms of adverse events.
Voriconazole Voriconazole, a strong CYP3A4 inhibitor, may increase the serum concentration of gefitinib by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of gefitinib if voriconazole is initiated, discontinued or dose changed.
Warfarin Gefitinib may increase the anticoagulant effect of warfarin.
Food Interactions
  • Take without regard to meals.
  • Avoid fresh grapefruit and its juice during therapy as grapefruit may increase serum product levels.

Targets


Epidermal growth factor receptor
Name Epidermal growth factor receptor
Gene Name EGFR
Pharmacological action yes
Actions antagonist
References
  • Ciardiello F, Caputo R, Bianco R, Damiano V, Pomatico G, De Placido S, Bianco AR, Tortora G: Antitumor effect and potentiation of cytotoxic drugs activity in human cancer cells by ZD-1839 (Iressa), an epidermal growth factor receptor-selective tyrosine kinase inhibitor. Clin Cancer Res. 2000 May;6(5):2053-63. - Pubmed
  • Albanell J, Codony-Servat J, Rojo F, Del Campo JM, Sauleda S, Anido J, Raspall G, Giralt J, Rosello J, Nicholson RI, Mendelsohn J, Baselga J: Activated extracellular signal-regulated kinases: association with epidermal growth factor receptor/transforming growth factor alpha expression in head and neck squamous carcinoma and inhibition by anti-epidermal growth factor receptor treatments. Cancer Res. 2001 Sep 1;61(17):6500-10. - Pubmed
  • Nicholson RI, Hutcheson IR, Harper ME, Knowlden JM, Barrow D, McClelland RA, Jones HE, Wakeling AE, Gee JM: Modulation of epidermal growth factor receptor in endocrine-resistant, oestrogen receptor-positive breast cancer. Endocr Relat Cancer. 2001 Sep;8(3):175-82. - Pubmed
  • Moasser MM, Basso A, Averbuch SD, Rosen N: The tyrosine kinase inhibitor ZD1839 ( - Iressa
  • Arteaga CL, Johnson DH: Tyrosine kinase inhibitors-ZD1839 (Iressa). Curr Opin Oncol. 2001 Nov;13(6):491-8. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 0.5721

Enzymes


Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.8264
Cytochrome P450 2D6
Name Cytochrome P450 2D6
Gene Name CYP2D6
Actions substrate,inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.5789
Cytochrome P450 3A5
Name Cytochrome P450 3A5
Gene Name CYP3A5
Actions Not Available
References
  • Li J, Zhao M, He P, Hidalgo M, Baker SD: Differential metabolism of gefitinib and erlotinib by human cytochrome P450 enzymes. Clin Cancer Res. 2007 Jun 15;13(12):3731-7. - Pubmed
DTHybrid score 0.4243
Cytochrome P450 1A1
Name Cytochrome P450 1A1
Gene Name CYP1A1
Actions substrate,inhibitor
References
  • Li J, Zhao M, He P, Hidalgo M, Baker SD: Differential metabolism of gefitinib and erlotinib by human cytochrome P450 enzymes. Clin Cancer Res. 2007 Jun 15;13(12):3731-7. - Pubmed
  • https://www.pharmgkb.org/pathway/PA152325160 -
DTHybrid score 0.2917
Cytochrome P450 2C9
Name Cytochrome P450 2C9
Gene Name CYP2C9
Actions inhibitor
References
  • https://www.pharmgkb.org/pathway/PA152325160 -
DTHybrid score 0.5425
Cytochrome P450 2C19
Name Cytochrome P450 2C19
Gene Name CYP2C19
Actions inhibitor
References
  • https://www.pharmgkb.org/pathway/PA152325160 -
DTHybrid score 0.4933

Transporters


Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions substrate,inhibitor
References
  • Shen J, Carcaboso AM, Hubbard KE, Tagen M, Wynn HG, Panetta JC, Waters CM, Elmeliegy MA, Stewart CF: Compartment-specific roles of ATP-binding cassette transporters define differential topotecan distribution in brain parenchyma and cerebrospinal fluid. Cancer Res. 2009 Jul 15;69(14):5885-92. Epub 2009 Jun 30. - Pubmed
DTHybrid score 0.5885
ATP-binding cassette sub-family G member 2
Name ATP-binding cassette sub-family G member 2
Gene Name ABCG2
Actions substrate,inhibitor
References
  • Ozvegy-Laczka C, Hegedus T, Varady G, Ujhelly O, Schuetz JD, Varadi A, Keri G, Orfi L, Nemet K, Sarkadi B: High-affinity interaction of tyrosine kinase inhibitors with the ABCG2 multidrug transporter. Mol Pharmacol. 2004 Jun;65(6):1485-95. - Pubmed
  • An Y, Ongkeko WM: ABCG2: the key to chemoresistance in cancer stem cells? Expert Opin Drug Metab Toxicol. 2009 Dec;5(12):1529-42. - Pubmed
  • Shen J, Carcaboso AM, Hubbard KE, Tagen M, Wynn HG, Panetta JC, Waters CM, Elmeliegy MA, Stewart CF: Compartment-specific roles of ATP-binding cassette transporters define differential topotecan distribution in brain parenchyma and cerebrospinal fluid. Cancer Res. 2009 Jul 15;69(14):5885-92. Epub 2009 Jun 30. - Pubmed
  • Noguchi K, Kawahara H, Kaji A, Katayama K, Mitsuhashi J, Sugimoto Y: Substrate-dependent bidirectional modulation of P-glycoprotein-mediated drug resistance by erlotinib. Cancer Sci. 2009 Sep;100(9):1701-7. Epub 2009 May 12. - Pubmed
  • Shi Z, Parmar S, Peng XX, Shen T, Robey RW, Bates SE, Fu LW, Shao Y, Chen YM, Zang F, Chen ZS: The epidermal growth factor tyrosine kinase inhibitor AG1478 and erlotinib reverse ABCG2-mediated drug resistance. Oncol Rep. 2009 Feb;21(2):483-9. - Pubmed
DTHybrid score 0.332

Carriers


Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions
References Not Available
DTHybrid score 0.5885
ATP-binding cassette sub-family G member 2
Name ATP-binding cassette sub-family G member 2
Gene Name ABCG2
Actions
References Not Available
DTHybrid score 0.332

Predictions


Id Partner name Gene Name Score
4200 Cytochrome P450 1A2 CYP1A2 0.3743
4924 Cytochrome P450 2C8 CYP2C8 0.3359
6107 Cytochrome P450 3A7 CYP3A7 0.2547
6030 Cytochrome P450 2B6 CYP2B6 0.2104
6013 Cytochrome P450 2E1 CYP2E1 0.1803
5718 Cytochrome P450 2A6 CYP2A6 0.1258
20 Prostaglandin G/H synthase 1 PTGS1 0.1153
862 Multidrug resistance-associated protein 1 ABCC1 0.1123
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.1051
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.1021
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0987
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0913
1898 Cytochrome P450 1B1 CYP1B1 0.086
492 Histamine H1 receptor HRH1 0.0853
1729 Solute carrier family 22 member 6 SLC22A6 0.0836
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0829
824 Sodium-dependent serotonin transporter SLC6A4 0.0819
6145 Solute carrier family 22 member 1 SLC22A1 0.0783
6106 Cytochrome P450 2C18 CYP2C18 0.0776
540 Sodium-dependent noradrenaline transporter SLC6A2 0.077
556 Alpha-1A adrenergic receptor ADRA1A 0.076
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0693
290 Prostaglandin G/H synthase 2 PTGS2 0.0682
6144 Solute carrier family 22 member 2 SLC22A2 0.0647
502 5-hydroxytryptamine 2A receptor HTR2A 0.0632
831 D(2) dopamine receptor DRD2 0.0607
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0601
320 5-hydroxytryptamine 1A receptor HTR1A 0.0593
776 Bile salt export pump ABCB11 0.0579
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.057
766 Beta-2 adrenergic receptor ADRB2 0.0561
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.055
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0539
3811 Cytochrome P450 19A1 CYP19A1 0.0538
6142 Solute carrier family 22 member 8 SLC22A8 0.0532
193 Beta-1 adrenergic receptor ADRB1 0.0524
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0503
632 Alpha-1B adrenergic receptor ADRA1B 0.0497
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0496
118 Organic cation/carnitine transporter 2 SLC22A5 0.0469
2164 Multidrug resistance-associated protein 4 ABCC4 0.0462
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0453
136 Estrogen receptor ESR1 0.0448
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0444
847 Mu-type opioid receptor OPRM1 0.0444
318 Alpha-2A adrenergic receptor ADRA2A 0.0443
871 Glucocorticoid receptor NR3C1 0.044
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0439
713 Sodium-dependent dopamine transporter SLC6A3 0.0435
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0419
731 HIV-1 protease HIV-1 protease 0.0415
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.041
23 D(1A) dopamine receptor DRD1 0.0408
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0407
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0401
6143 Solute carrier family 22 member 7 SLC22A7 0.0399
789 Alpha-1D adrenergic receptor ADRA1D 0.039
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0381
590 5-hydroxytryptamine 2C receptor HTR2C 0.0372
6147 Solute carrier family 22 member 3 SLC22A3 0.0368
891 Dihydropteroate synthase folP 0.0364
5359 Dihydropteroate synthase folP 0.0364
7175 Dihydropteroate synthase sulI 0.0364
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0363
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0363
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0359
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.035
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0349
817 DNA topoisomerase 2-alpha TOP2A 0.0347
468 Cytochrome P450 4A11 CYP4A11 0.0342
696 Kappa-type opioid receptor OPRK1 0.034
467 Delta-type opioid receptor OPRD1 0.0332
1024 Solute carrier family 22 member 11 SLC22A11 0.0332
183 Vascular endothelial growth factor A VEGFA 0.0329
465 Calmodulin CALM1 0.0328
341 5-hydroxytryptamine 3 receptor HTR3A 0.032
3941 Amine oxidase [flavin-containing] A MAOA 0.0319
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0313
5787 Angiopoietin-1 receptor TEK 0.0312
5300 Antigen peptide transporter 1 TAP1 0.0301
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0299
6031 Cytochrome P450 3A43 CYP3A43 0.0299
260 Cytochrome P450 51 ERG11 0.0291
761 Cytochrome P450 51 ERG11 0.0291
3163 Cytochrome P450 51 cyp51 0.0291
6148 Multidrug resistance-associated protein 7 ABCC10 0.0289
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0287
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0287
238 Peroxisome proliferator-activated receptor gamma PPARG 0.028
6182 Cytochrome P450 2J2 CYP2J2 0.0278
3923 Cholinesterase BCHE 0.0275
504 Mast/stem cell growth factor receptor KIT 0.0274
6137 Multidrug resistance-associated protein 6 ABCC6 0.0272
885 5-hydroxytryptamine 1B receptor HTR1B 0.0264
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0263
833 Organic cation/carnitine transporter 1 SLC22A4 0.0259
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0259
638 D(3) dopamine receptor DRD3 0.0257
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0257
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0254
122 P2Y purinoceptor 12 P2RY12 0.025
3939 Amine oxidase [flavin-containing] B MAOB 0.0244
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0243
146 Androgen receptor AR 0.0234
6141 Sodium/bile acid cotransporter SLC10A1 0.0233
629 Alpha-2B adrenergic receptor ADRA2B 0.023
4604 Liver carboxylesterase 1 CES1 0.0228
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0228
756 Sex hormone-binding globulin SHBG 0.0225
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0223
70 Type-1 angiotensin II receptor AGTR1 0.0223
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0223
2782 Complement C1s subcomponent C1S 0.0221
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0221
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0218
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0215
1353 DNA topoisomerase 1 TOP1 0.0215
3552 DNA topoisomerase 1 topA 0.0215
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0214
1517 Beta-3 adrenergic receptor ADRB3 0.0213
228 Beta platelet-derived growth factor receptor PDGFRB 0.0212
380 Cytochrome P450 17A1 CYP17A1 0.021
777 Tumor necrosis factor TNF 0.0209
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0207
378 Alpha-2C adrenergic receptor ADRA2C 0.0207
614 Progesterone receptor PGR 0.0207
725 5-hydroxytryptamine 1D receptor HTR1D 0.0203
3817 Complement C1q subcomponent subunit C C1QC 0.0202
3816 Complement C1q subcomponent subunit B C1QB 0.0202
3815 Complement C1q subcomponent subunit A C1QA 0.0202
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0201
3950 Cell division protein kinase 9 CDK9 0.02
1102 Low affinity immunoglobulin gamma Fc region receptor III-B FCGR3B 0.02
3818 Low affinity immunoglobulin gamma Fc region receptor III-A FCGR3A 0.02
3968 Cell division protein kinase 8 CDK8 0.02
3819 Low affinity immunoglobulin gamma Fc region receptor II-a FCGR2A 0.02
3821 Low affinity immunoglobulin gamma Fc region receptor II-c FCGR2C 0.02
3814 Complement C1r subcomponent C1R 0.02
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0199
3820 Low affinity immunoglobulin gamma Fc region receptor II-b FCGR2B 0.0198
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0198
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0197
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0192
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0191
784 High affinity immunoglobulin gamma Fc receptor I FCGR1A 0.0191
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0191
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.019
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0189
4120 NADPH--cytochrome P450 reductase POR 0.0185
1757 Myeloperoxidase MPO 0.0185
6220 Aryl hydrocarbon receptor AHR 0.0184
407 Vascular endothelial growth factor receptor 2 KDR 0.018
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0179
373 Transthyretin TTR 0.0176
3959 Cell division protein kinase 4 CDK4 0.0176
6014 Cytochrome P450 2A13 CYP2A13 0.0175
6136 Multidrug resistance-associated protein 5 ABCC5 0.0174
436 5-hydroxytryptamine 2B receptor HTR2B 0.0173
432 D(4) dopamine receptor DRD4 0.0173
3482 Cell division protein kinase 7 CDK7 0.0172
124 Histamine H2 receptor HRH2 0.0172
33 Cystine/glutamate transporter SLC7A11 0.0172
738 Monocarboxylate transporter 1 SLC16A1 0.0172
26 Vascular endothelial growth factor receptor 3 FLT4 0.0171
869 Estrogen receptor beta ESR2 0.017
1389 Transforming growth factor beta-1 TGFB1 0.0169
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0168
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0167
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0167
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0165
32 Vascular endothelial growth factor receptor 1 FLT1 0.0163
1656 CYP2B protein CYP2B 0.0162
3955 Cell division protein kinase 6 CDK6 0.0162
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0161
29 Tubulin beta-1 chain TUBB1 0.0154
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0154
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0151
161 Tubulin beta chain TUBB 0.0151
312 Tubulin beta chain TUB2 0.0151
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0151
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0151
232 Corticosteroid-binding globulin SERPINA6 0.015
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0149
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0147
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0144
811 Translocator protein TSPO 0.0144
6541 Peptostreptococcal albumin-binding protein pab 0.0142
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.014
1742 D-HSCDK2 CDK2deltaT 0.014
1771 Cell division control protein 2 homolog CDK1 0.014
3321 Cell division control protein 2 homolog CRK2 0.014
716 5-hydroxytryptamine 7 receptor HTR7 0.0139
705 Glutamate receptor 1 GRIA1 0.0139
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0138
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0138
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0138
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0137
474 Acetylcholinesterase ACHE 0.0137
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0136
1058 Cell division protein kinase 5 CDK5 0.0135
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0135
3947 Xanthine dehydrogenase/oxidase XDH 0.0135
2449 Tubulin alpha-3 chain TUBA1A 0.0135
4148 Serine/threonine-protein kinase mTOR MTOR 0.0134
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0134
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0134
737 Mineralocorticoid receptor NR3C2 0.0132
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0132
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0132
768 FK506-binding protein 1A FKBP1A 0.013
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.013
2499 Tubulin beta-2C chain TUBB2C 0.0129
2539 Tubulin alpha-1 chain TUBA4A 0.0129
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0129
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0128
1618 High affinity nerve growth factor receptor NTRK1 0.0128
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0127
6085 Fatty acid-binding protein, intestinal FABP2 0.0127
3932 Glutathione S-transferase A2 GSTA2 0.0126
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0125
1050 Bile salt sulfotransferase SULT2A1 0.0124
1010 Cytochrome P450 51A1 CYP51A1 0.0124
482 Glycine receptor subunit alpha-1 GLRA1 0.0123
4773 Deoxycytidine kinase DCK 0.0122
952 Dipeptidyl peptidase 4 DPP4 0.0121
6102 Arylamine N-acetyltransferase 2 NAT2 0.0121
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.012
1192 Sulfotransferase 1A1 SULT1A1 0.012
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0118
68 Cannabinoid receptor 1 CNR1 0.0118
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0117
48 Pyridoxal kinase PDXK 0.0116
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0115
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0115
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0115
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0115
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0115
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0115
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0115
818 50S ribosomal protein L10 rplJ 0.0114
163 D(1B) dopamine receptor DRD5 0.0114
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0113
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.011
4203 Histamine N-methyltransferase HNMT 0.011
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.011
2112 Toll-like receptor 9 TLR9 0.0109
823 Fibroblast growth factor receptor 2 FGFR2 0.0109
295 Carbonic anhydrase 1 CA1 0.0107
592 Carbonic anhydrase 4 CA4 0.0105
2211 Fatty acid-binding protein, heart FABP3 0.0105
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0105
904 Glutathione S-transferase P GSTP1 0.0104
117 Sterol O-acyltransferase 1 SOAT1 0.0104
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0104
528 5-hydroxytryptamine 1E receptor HTR1E 0.0103
165 FL cytokine receptor FLT3 0.0103
1256 5-hydroxytryptamine 6 receptor HTR6 0.0103
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0102
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0102
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0102
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0101
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.01
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0099
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0099
6146 High affinity copper uptake protein 1 SLC31A1 0.0098
6599 HTH-type transcriptional regulator ttgR ttgR 0.0097
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0097
239 Coagulation factor X F10 0.0097
49 Endothelin B receptor EDNRB 0.0096
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0095
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0095
365 Dihydrofolate reductase DHFR 0.0095
2381 Dihydrofolate reductase DFR1 0.0095
2833 Dihydrofolate reductase Not Available 0.0095
2931 Dihydrofolate reductase folA 0.0095
3544 Dihydrofolate reductase folA 0.0095
3682 Dihydrofolate reductase folA 0.0095
6642 Dihydrofolate reductase folA 0.0095
6756 Dihydrofolate reductase dfrA 0.0095
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0095
566 Serotransferrin TF 0.0094
477 DNA topoisomerase 4 subunit A parC 0.0094
886 DNA topoisomerase 4 subunit A parC 0.0094
6226 DNA topoisomerase 4 subunit A parC 0.0094
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0094
106 Cannabinoid receptor 2 CNR2 0.0094
94 5-hydroxytryptamine 4 receptor HTR4 0.0093
404 DNA gyrase subunit A gyrA 0.0093
6224 DNA gyrase subunit A gyrA 0.0093
992 Protein tyrosine kinase 2 beta PTK2B 0.0092
244 Angiotensin-converting enzyme ACE 0.0092
6432 Transporter snf 0.0091
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0091
6043 Putative G-protein coupled receptor 44 GPR44 0.0091
1852 Microtubule-associated protein 2 MAP2 0.009
1152 Glycogen phosphorylase, muscle form PYGM 0.009
578 Endothelin-1 receptor EDNRA 0.009
537 ATP synthase delta chain, mitochondrial ATP5D 0.009
613 Atrial natriuretic peptide receptor A NPR1 0.009
427 Substance-P receptor TACR1 0.009
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0089
3810 Catechol O-methyltransferase COMT 0.0088
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0088
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0088
357 Carbonic anhydrase 2 CA2 0.0088
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0087
2240 Cell division protein kinase 2 CDK2 0.0087
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0087
131 Synaptic vesicular amine transporter SLC18A2 0.0086
461 Glycine receptor subunit alpha-3 GLRA3 0.0086
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0086
275 Arachidonate 5-lipoxygenase ALOX5 0.0086
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0086
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0086
469 Annexin A1 ANXA1 0.0085
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0085
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0085
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0085
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0085
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0085
1178 Adenosine A2a receptor ADORA2A 0.0085
571 Melatonin receptor type 1A MTNR1A 0.0084
362 Melatonin receptor type 1B MTNR1B 0.0084
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0084
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0083
605 Fumarate reductase flavoprotein subunit frdA 0.0083
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0083
3673 Fumarate reductase flavoprotein subunit fccA 0.0083
4912 Fumarate reductase flavoprotein subunit ifcA 0.0083
6549 Fumarate reductase flavoprotein subunit frdA 0.0083
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0083
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0083
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0082
24 Thymidylate synthase TMP1 0.0081
359 Thymidylate synthase TYMS 0.0081
2626 Thymidylate synthase thyA 0.0081
2729 Thymidylate synthase thyA 0.0081
5352 Thymidylate synthase THYA 0.0081
908 Glutathione S-transferase theta-1 GSTT1 0.0081
273 Apoptosis regulator Bcl-2 BCL2 0.0081
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0081
6525 Group IID secretory phospholipase A2 PLA2G2D 0.008
645 Penicillin-binding protein 1A mrcA 0.0078
5805 Penicillin-binding protein 1A ponA 0.0078
6185 Penicillin-binding protein 1A mrcA 0.0078
6799 Penicillin-binding protein 1A pbpA 0.0078
442 Envelope glycoprotein gp41 0.0078
4859 Envelope glycoprotein env 0.0078
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0078
4311 tRNA TRDMT1 0.0078
4325 tRNA trmD 0.0078
4328 tRNA trmD 0.0078
54 Prothrombin F2 0.0077
814 Ryanodine receptor 1 RYR1 0.0077
4237 50S ribosomal protein L22 rplV 0.0076
1864 RET proto-oncogene RET 0.0076
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0076
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0076
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0076
6020 Aldehyde oxidase AOX1 0.0076
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0075
780 Retinoic acid receptor RXR-gamma RXRG 0.0075
1629 Transcription factor AP-1 JUN 0.0075
603 DNA polymerase alpha catalytic subunit POLA1 0.0074
3856 Fibroblast growth factor receptor 3 FGFR3 0.0074
558 Solute carrier family 12 member 1 SLC12A1 0.0073
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0073
4116 Dihydropteroate synthetase Not Available 0.0072
543 Penicillin-binding protein 1B mrcB 0.0072
6186 Penicillin-binding protein 1B ponB 0.0072
6822 Penicillin-binding protein 1b pbp1b 0.0072
6844 Penicillin-binding protein 1b pbp1b 0.0072
84 Nuclear receptor 0B1 NR0B1 0.0072
1 Peptidoglycan synthetase ftsI ftsI 0.0071
4155 Peptidoglycan synthetase ftsI ftsI 0.0071
1650 Heme carrier protein 1 SLC46A1 0.0071
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0071
936 Ephrin type-A receptor 2 EPHA2 0.0071
1714 Mitogen-activated protein kinase 3 MAPK3 0.0071
5923 Microtubule-associated protein tau MAPT 0.0071
5924 Microtubule-associated protein 4 MAP4 0.0071
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.007
3426 Glutamine synthetase glnA 0.007
3987 Glutamine synthetase GLUL 0.007
4228 Keratin, type II cytoskeletal 7 KRT7 0.007
6126 Carbonic anhydrase 7 CA7 0.007
459 Retinoic acid receptor RXR-alpha RXRA 0.007
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0069
4192 DNA topoisomerase 2-beta TOP2B 0.0068
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0068
2853 14 kDa fatty acid-binding protein Not Available 0.0068
88 Retinoic acid receptor RXR-beta RXRB 0.0068
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0068
5934 Cytochrome P450 26A1 CYP26A1 0.0068
16 Adenosine A1 receptor ADORA1 0.0067
723 Cytosolic phospholipase A2 PLA2G4A 0.0067
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0067
36 Insulin receptor INSR 0.0066
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0066
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0066
820 Glycine receptor subunit alpha-2 GLRA2 0.0066
856 Vitamin D3 receptor VDR 0.0066
6149 Solute carrier family 22 member 10 SLC22A10 0.0066
4103 Proteasome subunit beta type 2 PSMB2 0.0065
4102 Proteasome subunit beta type 5 PSMB5 0.0065
4101 Proteasome subunit beta type 1 PSMB1 0.0065
1992 Vitamin D-binding protein GC 0.0065
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0065
511 5-hydroxytryptamine 1F receptor HTR1F 0.0064
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0064
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0064
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0064
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0064
3432 Multidrug-efflux transporter 1 regulator bmrR 0.0063
4476 Mannitol dehydrogenase mtlD 0.0063
1119 Peroxiredoxin-5, mitochondrial PRDX5 0.0063
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0063
133 Dihydropterate synthase sulI 0.0063
4238 50S ribosomal protein L4 rplD 0.0063
5578 50S ribosomal protein L4 rplD 0.0063
6173 50S ribosomal protein L4 rplD 0.0063
6219 50S ribosomal protein L4 rplD 0.0063
2183 Fatty acid-binding protein, adipocyte FABP4 0.0063
3917 Methylenetetrahydrofolate reductase MTHFR 0.0062
319 Opioid receptor, sigma 1 OPRS1 0.0062
6163 Copper-transporting ATPase 2 ATP7B 0.0062
6165 Copper-transporting ATPase 1 ATP7A 0.0062
3809 Estrogen-related receptor gamma ESRRG 0.0062
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0062
4122 Histone deacetylase 2 HDAC2 0.0061
153 Dopamine beta-hydroxylase DBH 0.0061
176 30S ribosomal protein S10 rpsJ 0.006
6175 30S ribosomal protein S10 rpsJ 0.006
4117 Probable pyruvate-flavodoxin oxidoreductase ydbK 0.006
976 Platelet glycoprotein IX GP9 0.006
185 Vasopressin V1a receptor AVPR1A 0.006
633 Penicillin-binding proteins 1A/1B pbpA 0.0059
208 DNA-directed RNA polymerase beta' chain rpoC 0.0059
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0059
1275 Estrogen sulfotransferase SULT1E1 0.0059
581 Cytochrome P450 2R1 CYP2R1 0.0059
921 Glutamate receptor 2 GRIA2 0.0059
896 Glutathione S-transferase Mu 1 GSTM1 0.0058
3382 Glycolipid transfer protein GLTP 0.0058
322 Vasopressin V2 receptor AVPR2 0.0058
790 DNA polymerase subunit alpha B POLA2 0.0058
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0058
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0058
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0057
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0057
685 Oxygen-insensitive NADPH nitroreductase nfsA 0.0057
6945 Oxygen-insensitive NADPH nitroreductase rdxA 0.0057
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0056
6174 50S ribosomal protein L32 rpmF 0.0056
6766 O-GlcNAcase BT_4395 BT_4395 0.0056
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0056
6506 Stathmin-4 STMN4 0.0055
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0054
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0054
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0054
1063 Signal transducer and activator of transcription 5B STAT5B 0.0054
4217 Telomerase reverse transcriptase TERT 0.0054
594 Thyroxine-binding globulin SERPINA7 0.0053
6138 Multidrug resistance protein 3 ABCB4 0.0053
6339 Ig kappa chain V-II region RPMI 6410 Not Available 0.0052
174 Sigma 1-type opioid receptor SIGMAR1 0.0052
7 Nitric oxide synthase, inducible NOS2 0.0052
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0051
887 DNA gyrase subunit B gyrB 0.0051
4150 DNA gyrase subunit B gyrB 0.0051
6225 DNA gyrase subunit B gyrB 0.0051
6824 Tyrosine-protein kinase Lyn LYN 0.0051
65 Matrix metalloproteinase-9 Not Available 0.0051
1525 Heparin-binding growth factor 2 FGF2 0.0051
2616 Ganglioside GM2 activator GM2A 0.0051
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.005
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.005
6027 Alkaline phosphatase, tissue-nonspecific isozyme ALPL 0.005
758 Thyroid hormone receptor alpha THRA 0.0049
173 Toll-like receptor 7 TLR7 0.0049
6184 D-alanyl-D-alanine carboxypeptidase dacC dacC 0.0048
2981 Phospholipase A2, membrane associated PLA2G2A 0.0048
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0048
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0048
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0048
1176 Mitogen-activated protein kinase 1 MAPK1 0.0047
751 Potassium channel subfamily K member 6 KCNK6 0.0047
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0047
484 Tyrosine-protein kinase ABL2 ABL2 0.0047
634 Squalene monooxygenase SQLE 0.0047
7196 Squalene monooxygenase ERG1 0.0047
683 Potassium transporter GK0582 0.0047
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0046
1770 Phospholipase C PLCL1 0.0046
2841 Phospholipase C plc 0.0046
565 Extracellular calcium-sensing receptor CASR 0.0046
3086 Plasmepsin-2 Not Available 0.0046
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0046
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0046
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0046
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0045
527 Prostacyclin receptor PTGIR 0.0045
284 DNA-directed RNA polymerase beta chain rpoB 0.0045
5773 DNA-directed RNA polymerase beta chain rpoB 0.0045
1196 Complement decay-accelerating factor CD55 0.0045
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0045
115 Penicillin-binding protein 2 mrdA 0.0044
6069 Penicillin-binding protein 2 mrdA 0.0044
6118 Penicillin-binding protein 2 penA 0.0044
6187 Penicillin-binding protein 2 pbpA 0.0044
6686 Penicillin-binding protein 2 pbp2 0.0044
6939 Penicillin-binding protein 2 mrdA 0.0044
7163 Penicillin-binding protein 2 pbpA 0.0044
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0044
346 Thyroid hormone receptor beta-1 THRB 0.0044
130 Prostacyclin synthase PTGIS 0.0044
1820 Beta-nerve growth factor NGF 0.0044
2178 Metabotropic glutamate receptor 5 GRM5 0.0044
5645 DNA topoisomerase 4 subunit B parE 0.0044
6227 DNA topoisomerase 4 subunit B parE 0.0044
707 72 kDa type IV collagenase MMP2 0.0044
1483 Membrane copper amine oxidase AOC3 0.0043
2216 Fibroblast growth factor receptor 4 FGFR4 0.0043
162 Retinoic acid receptor gamma-1 RARG 0.0043
518 Peroxidase/catalase T katG 0.0043
172 Potassium channel subfamily K member 1 KCNK1 0.0043
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0043
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0043
1630 Integrin beta-2 ITGB2 0.0043
2320 Thymidine kinase, cytosolic TK1 0.0043
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0042
6103 Arylamine N-acetyltransferase 1 NAT1 0.0042
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0042
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0041
164 Histamine H4 receptor HRH4 0.0041
293 Gamma-glutamyl hydrolase GGH 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
1374 Natriuretic peptides B NPPB 0.004
1827 Gap junction alpha-1 protein GJA1 0.004
1908 Vascular cell adhesion protein 1 VCAM1 0.004
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.004
6508 Putative uncharacterized protein srtB 0.004
6543 Putative uncharacterized protein tcp14 0.004
6615 Putative uncharacterized protein MT0785 0.004
6623 Putative uncharacterized protein Not Available 0.004
6806 Putative uncharacterized protein AGR_C_2535 0.004
6813 Putative uncharacterized protein SAV4671 0.004
6815 Putative uncharacterized protein AFE_1514 0.004
6819 Putative uncharacterized protein RUMGNA_03254 0.004
6825 Putative uncharacterized protein CV_3270 0.004
4161 Furin FURIN 0.004
569 Retinal dehydrogenase 2 ALDH1A2 0.004
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.004
3639 Thymidine phosphorylase deoA 0.0039
3936 Thymidine phosphorylase TYMP 0.0039
1541 Metalloproteinase mmp20 0.0039
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0039
2808 Chloramphenicol acetyltransferase 3 cat3 0.0039
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0039
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0039
4146 Phosphatidylinositol 3-kinase regulatory subunit gamma PIK3R3 0.0039
4145 Phosphatidylinositol 3-kinase regulatory subunit beta PIK3R2 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0038
6067 Penicillin binding protein 2a mecA 0.0038
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0038
6677 Myelin P2 protein PMP2 0.0038
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0038
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0038
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0038
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0038
1569 G1/S-specific cyclin-D1 CCND1 0.0038
233 Potassium channel subfamily K member 2 KCNK2 0.0038
1760 Aminopeptidase N ANPEP 0.0038
6843 Aminopeptidase N pepN 0.0038
85 Growth hormone receptor GHR 0.0038
563 Thyroid peroxidase TPO 0.0037
3937 Fatty-acid amide hydrolase FAAH 0.0037
6167 Organic solute transporter subunit beta OSTB 0.0037
6166 Organic solute transporter subunit alpha OSTA 0.0037
611 Retinal dehydrogenase 1 ALDH1A1 0.0037
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0037
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0037
2599 Tyrosine-protein kinase HCK HCK 0.0036
1360 Sphingomyelin phosphodiesterase SMPD1 0.0036
819 Penicillin-binding protein 4 dacB 0.0036
3601 Dihydropteroate synthase 1 folP1 0.0036
3807 Dihydropteroate synthase 1 folP1 0.0036
3808 Dihydropteroate synthase 2 folP2 0.0036
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0036
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0036
2417 Chloramphenicol acetyltransferase cat 0.0036
3278 Chloramphenicol acetyltransferase cat 0.0036
4210 Toll-like receptor 4 TLR4 0.0035
3830 Calreticulin CALR 0.0035
4226 Uridine phosphorylase 2 UPP2 0.0035
2810 Dr hemagglutinin structural subunit draA 0.0035
6044 Serum paraoxonase/lactonase 3 PON3 0.0035
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0035
2300 Lysozyme E 0.0035
3633 Lysozyme R 0.0035
5597 Lysozyme 17 0.0035
939 50S ribosomal protein L3 rplC 0.0035
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0035
267 Plasminogen activator inhibitor 1 SERPINE1 0.0034
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0034
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0034
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0034
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0034
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0034
5798 Mitogen-activated protein kinase 11 MAPK11 0.0034
1281 Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 0.0033
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0033
4225 Uridine phosphorylase 1 UPP1 0.0033
6034 Hydroxyindole O-methyltransferase ASMT 0.0033
6035 Nuclear receptor ROR-beta RORB 0.0033
6036 Eosinophil peroxidase EPX 0.0033
572 Integrin alpha-L ITGAL 0.0032
719 Retinoic acid receptor responder protein 1 RARRES1 0.0032
770 Retinoic acid-induced protein 3 GPRC5A 0.0032
331 Retinol-binding protein I, cellular RBP1 0.0032
251 Alcohol dehydrogenase 1A ADH1A 0.0032
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0032
1867 Major prion protein PRNP 0.0032
444 Alcohol dehydrogenase 1B ADH1B 0.0032
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0032
1291 cAMP response element-binding protein CREB1 0.0032
2107 Microtubule-associated protein 1A MAP1A 0.0032
595 Fibrinogen alpha chain FGA 0.0032
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0031
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0031
1636 Trace amine-associated receptor 1 TAAR1 0.0031
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0031
489 Monocarboxylate transporter 2 SLC16A7 0.0031
199 Monocarboxylate transporter 8 SLC16A2 0.0031
2236 Casein kinase II subunit alpha CSNK2A1 0.0031
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0031
6221 Steroid hormone receptor ERR1 ESRRA 0.0031
1227 Cytochrome b MT-CYB 0.0031
6386 Cytochrome b petB 0.0031
6937 Cytochrome b MT-CYB 0.0031
674 Dihydroorotate dehydrogenase homolog, mitochondrial PFF0160c 0.0031
3760 Penicillin-binding protein 5 precursor dacA 0.0031
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0031
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0031
2578 Tubulin beta-3 chain TUBB3 0.003
413 Amidophosphoribosyltransferase PPAT 0.003
2515 Amidophosphoribosyltransferase purF 0.003
3714 Amidophosphoribosyltransferase purF 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
702 UMP-CMP kinase CMPK1 0.003
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.003
3611 Cytidine deaminase cdd 0.003
3707 Cytidine deaminase cdd 0.003
4211 Cytidine deaminase CDA 0.003
6048 Troponin C, skeletal muscle TNNC2 0.0029
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0029
3813 Fibrinogen gamma chain FGG 0.0029
3812 Fibrinogen beta chain [Contains: Fibrinopeptide B] FGB 0.0029
2207 Rhodopsin RHO 0.0029
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0029
6033 High affinity interleukin-8 receptor A CXCR1 0.0029
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0029
765 Indoleamine 2,3-dioxygenase IDO1 0.0029
268 Adenosine A2b receptor ADORA2B 0.0029
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0028
3957 Adenosine deaminase ADA 0.0028
822 Aldose reductase AKR1B1 0.0028
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0028
6207 30S ribosomal protein S14 rpsN 0.0028
6209 30S ribosomal protein S19 rpsS 0.0028
6712 30S ribosomal protein S19 rpsS 0.0028
6726 30S ribosomal protein S19 rpsS 0.0028
1278 Pro-epidermal growth factor EGF 0.0028
1200 AMBP protein AMBP 0.0028
3866 Serum amyloid A protein SAA1 0.0028
1932 Apolipoprotein E APOE 0.0028
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0028
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0027
2021 Thrombomodulin THBD 0.0027
6232 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short GNAS 0.0027
6233 Adenylate cyclase type 2 ADCY2 0.0027
6234 Adenylate cyclase type 5 ADCY5 0.0027
1144 Hepatocyte growth factor receptor MET 0.0027
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
2159 Quinone oxidoreductase CRYZ 0.0027
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0027
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0027
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0027
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0027
144 Hemoglobin subunit alpha HBA1 0.0027
517 Alcohol dehydrogenase 1C ADH1C 0.0027
889 3-oxoacyl-[acyl-carrier-protein] synthase 1 fabB 0.0027
6860 3-oxoacyl-[acyl-carrier-protein] synthase 1 kasA 0.0027
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0026
6228 Nuclear receptor coactivator 1 NCOA1 0.0026
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0026
804 Mitochondrial folate transporter/carrier SLC25A32 0.0026
718 Folate receptor gamma FOLR3 0.0026
299 Folate receptor beta FOLR2 0.0026
6131 Carbonic anhydrase 14 CA14 0.0026
3913 Glutamic acid decarboxylase GAD65 0.0026
6218 Pannexin-1 PANX1 0.0025
1385 Angiotensin-converting enzyme 2 ACE2 0.0025
4252 Penicillin-binding protein 5 dacA 0.0025
6837 Serine/threonine-protein kinase 17B STK17B 0.0025
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0025
6151 Monocarboxylate transporter 10 SLC16A10 0.0025
229 Retinoic acid receptor beta RARB 0.0025
760 Fibroblast growth factor 1 FGF1 0.0024
1648 Elastin ELN 0.0024
730 Retinoic acid receptor alpha RARA 0.0024
291 Nitric-oxide synthase, endothelial NOS3 0.0024
3616 Fatty acid-binding protein, epidermal FABP5 0.0024
5431 Lipid binding protein Not Available 0.0024
5433 UPF0230 protein TM_1468 TM_1468 0.0024
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0024
159 Penicillin-binding protein 2B penA 0.0024
6121 Penicillin-binding protein 2B penA 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
6122 Carbonic anhydrase 3 CA3 0.0024
6231 Pepsin A PGA3 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
6171 Solute carrier family 28 member 3 SLC28A3 0.0024
6459 Glycodelin PAEP 0.0024
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0024
4221 Vascular endothelial growth factor VEGF 0.0023
5816 Cadherin-5 CDH5 0.0023
332 Beta-lactamase blaZ 0.0023
2478 Beta-lactamase ampC 0.0023
2613 Beta-lactamase ampC 0.0023
2635 Beta-lactamase ampC 0.0023
2700 Beta-lactamase penP 0.0023
5445 Beta-lactamase blaB 0.0023
6019 Beta-lactamase SHV-7 0.0023
6701 Beta-lactamase cphA 0.0023
6241 Nuclear receptor coactivator 2 NCOA2 0.0023
6501 Fatty acid-binding protein, liver FABP1 0.0023
1341 Histamine H3 receptor HRH3 0.0023
342 P protein [Includes: DNA-directed DNA polymerase P 0.0023
612 P protein [Includes: DNA-directed DNA polymerase P 0.0023
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0022
1262 Corticotropin-lipotropin POMC 0.0022
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0022
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0022
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0022
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0022
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0022
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0022
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0022
6111 DNA polymerase epsilon subunit 4 POLE4 0.0022
6112 DNA polymerase epsilon subunit 3 POLE3 0.0022
6110 DNA polymerase epsilon subunit 2 POLE2 0.0022
6108 Ribonucleoside-diphosphate reductase subunit M2 B RRM2B 0.0022
6109 DNA polymerase epsilon catalytic subunit A POLE 0.0022
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0022
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0022
3404 Exotoxin A eta 0.0022
2232 Interleukin-5 IL5 0.0022
3904 Alanine aminotransferase 2 GPT2 0.0021
735 Alanine aminotransferase 1 GPT 0.0021
298 Renin REN 0.0021
1593 Mucin-2 MUC2 0.0021
5818 Folate receptor alpha FOLR1 0.0021
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0021
6211 Tubulin epsilon chain TUBE1 0.0021
6212 Tubulin gamma-1 chain TUBG1 0.0021
6210 Tubulin delta chain TUBD1 0.0021
63 Malate dehydrogenase mdh 0.0021
2329 Malate dehydrogenase mdh 0.0021
3445 Malate dehydrogenase mdh 0.0021
4420 Malate dehydrogenase mdh 0.0021
4438 Malate dehydrogenase mdh 0.0021
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0021
1268 Neuropeptide S receptor NPSR1 0.002
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.002
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.002
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.002
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.002
3090 Chitosanase csn 0.002
4149 Nuclear factor NF-kappa-B p100 subunit NFKB2 0.002
5626 Nucleoside diphosphate kinase B NME2 0.002
6042 Prostaglandin reductase 2 PTGR2 0.002
283 SEC14-like protein 2 SEC14L2 0.002
4218 Ribonucleoside-diphosphate reductase M2 subunit RRM2 0.002
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.002
6755 Poliovirus receptor PVR 0.002
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.002
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0019
1039 Histone deacetylase 9 HDAC9 0.0019
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0019
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0019
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0019
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0019
6168 Solute carrier family 22 member 16 SLC22A16 0.0019
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0019
1792 Tissue-type plasminogen activator PLAT 0.0019
473 L-lactate dehydrogenase A chain LDHA 0.0019
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0019
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0019
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0019
6073 Potassium channel subfamily K member 9 KCNK9 0.0019
6072 Potassium channel subfamily K member 3 KCNK3 0.0019
893 [Citrate [pro-3S]-lyase] ligase citC 0.0018
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0018
1253 Interferon gamma IFNG 0.0018
5998 Toll-like receptor 8 TLR8 0.0018
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0018
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0018
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0018
712 Tubulin alpha chain TUB1 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
327 Glutathione reductase gor 0.0018
5110 Glutathione reductase GR2 0.0018
3312 Fatty acid-binding protein, brain FABP7 0.0018
1198 Serum paraoxonase/arylesterase 1 PON1 0.0018
6223 Penicillin-binding protein 1C pbpC 0.0018
1123 Eosinophil cationic protein RNASE3 0.0018
2408 Tyrosine-protein kinase SYK SYK 0.0018
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
3587 Gastrotropin FABP6 0.0017
2290 ADP-ribosyl cyclase 2 BST1 0.0017
5294 Nucleoside diphosphate kinase A NME1 0.0017
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0017
400 Coagulation factor IX F9 0.0017
5461 Coagulation factor IX F9 0.0017
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0017
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0016
3007 Carbonic anhydrase 12 CA12 0.0016
4205 Carbonic anhydrase 9 CA9 0.0016
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0016
2297 Genome polyprotein Not Available 0.0016
2322 Genome polyprotein Not Available 0.0016
2694 Genome polyprotein Not Available 0.0016
2719 Genome polyprotein Not Available 0.0016
2860 Genome polyprotein Not Available 0.0016
2928 Genome polyprotein Not Available 0.0016
3160 Genome polyprotein Not Available 0.0016
3260 Genome polyprotein Not Available 0.0016
4783 Genome polyprotein Not Available 0.0016
5726 Genome polyprotein Not Available 0.0016
5779 Genome polyprotein Not Available 0.0016
5867 Genome polyprotein Not Available 0.0016
6253 Genome polyprotein Not Available 0.0016
6301 Genome polyprotein Not Available 0.0016
6380 Genome polyprotein Not Available 0.0016
6381 Genome polyprotein Not Available 0.0016
6437 Genome polyprotein Not Available 0.0016
6520 Genome polyprotein Not Available 0.0016
6521 Genome polyprotein Not Available 0.0016
6652 Genome polyprotein Not Available 0.0016
6734 Genome polyprotein Not Available 0.0016
6735 Genome polyprotein Not Available 0.0016
6736 Genome polyprotein Not Available 0.0016
6737 Genome polyprotein Not Available 0.0016
6738 Genome polyprotein Not Available 0.0016
6739 Genome polyprotein Not Available 0.0016
6744 Genome polyprotein Not Available 0.0016
6748 Genome polyprotein Not Available 0.0016
6894 Genome polyprotein Not Available 0.0016
6898 Genome polyprotein Not Available 0.0016
1313 Lactoylglutathione lyase GLO1 0.0016
3233 Bile acid receptor NR1H4 0.0015
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0015
604 Vitamin K-dependent protein Z PROZ 0.0015
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0015
76 Nitric-oxide synthase, brain NOS1 0.0015
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0015
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0015
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0015
422 Vitamin K-dependent protein C PROC 0.0014
1245 Vitamin K-dependent protein S PROS1 0.0014
2129 Sucrase-isomaltase, intestinal SI 0.0014
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.0014
277 Purine nucleoside phosphorylase PNP 0.0014
2870 Purine nucleoside phosphorylase punA 0.0014
2945 Purine nucleoside phosphorylase punA 0.0014
4659 Purine nucleoside phosphorylase TM_1596 0.0014
4825 Purine nucleoside phosphorylase TTHA1435 0.0014
561 Retinol-binding protein II, cellular RBP2 0.0013
35 Dehydrogenase/reductase SDR family member 4 DHRS4 0.0013
4073 Retinol dehydrogenase 11 RDH11 0.0013
4074 Retinol dehydrogenase 14 RDH14 0.0013
1097 Lecithin retinol acyltransferase LRAT 0.0013
589 Retinoid-binding protein 7 RBP7 0.0013
753 Retinol-binding protein III, cellular RBP5 0.0013
4071 Short-chain dehydrogenase/reductase 3 DHRS3 0.0013
4075 Photoreceptor outer segment all-trans retinol dehydrogenase RDH8 0.0013
863 Cellular retinaldehyde-binding protein RLBP1 0.0013
800 Retinol dehydrogenase 12 RDH12 0.0013
282 Interphotoreceptor retinoid-binding protein RBP3 0.0013
651 Retinol dehydrogenase 13 RDH13 0.0013
4072 All-trans-retinol 13,14-reductase RETSAT 0.0013
860 Nicotinamide N-methyltransferase NNMT 0.0013
699 Nicotinic acid receptor 1 GPR109A 0.0013
928 Nicotinic acid receptor 2 GPR109B 0.0013
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0013
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
1405 Thiopurine S-methyltransferase TPMT 0.0013
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0012
6116 Gastric triacylglycerol lipase LIPF 0.0012
3221 Cytochrome c4 cc4 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
694 Matrix protein 2 M 0.0012
3823 Cytokine receptor common gamma chain IL2RG 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
997 Protein kinase C beta type PRKCB 0.0012
1295 Fatty acid synthase FASN 0.0012
6859 Protein S100-A4 S100A4 0.0012
627 11-cis retinol dehydrogenase RDH5 0.0011
640 Aldehyde dehydrogenase 1A3 ALDH1A3 0.0011
798 Osteocalcin BGLAP 0.0011
1970 Protein kinase C alpha type PRKCA 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
724 Interleukin-2 receptor alpha chain IL2RA 0.0011
717 Interleukin-2 receptor subunit beta IL2RB 0.0011
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
2461 D-alanyl-D-alanine carboxypeptidase Not Available 0.001
5756 D-alanyl-D-alanine carboxypeptidase dac 0.001
369 Coagulation factor VII F7 0.001
4948 Cytochrome c-553 Not Available 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
4923 Cytochrome c3 DvMF_2499 0.001
4945 Cytochrome c3 Not Available 0.001
4949 Cytochrome c3 DVU_3171 0.001
4968 Cytochrome c3 cytc3 0.001
4997 Cytochrome c3 SO_2727 0.001
5219 Cytochrome c3 cyd 0.001
4902 Nine-heme cytochrome c Ddes_2038 0.001
3189 High-molecular-weight cytochrome c hmcA 0.001
345 Plasma retinol-binding protein RBP4 0.001
512 DNA-directed RNA polymerase alpha chain rpoA 0.001
5772 DNA-directed RNA polymerase alpha chain rpoA 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
2473 Tyrosine-protein kinase CSK CSK 0.001
2398 Tyrosine-protein kinase ZAP-70 ZAP70 0.001
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.001
2268 Cholesterol oxidase choB 0.0009
2822 Cholesterol oxidase choA 0.0009
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0009
828 Phenylalanine-4-hydroxylase PAH 0.0009
3109 Phenylalanine-4-hydroxylase phhA 0.0009
1048 Protein S100-A13 S100A13 0.0009
2226 Protein S100-A12 S100A12 0.0009
2283 Steroid Delta-isomerase ksi 0.0009
2920 Steroid Delta-isomerase ksi 0.0009
2298 Cytochrome P450-cam camC 0.0009
4386 Hemoglobin-like protein HbN glbN 0.0009
390 Adenosine A3 receptor ADORA3 0.0009
2132 Protein S100-B S100B 0.0009
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
500 Monocarboxylate transporter 4 SLC16A3 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
2530 Protein kinase C theta type PRKCQ 0.0008
1025 Aquaporin-1 AQP1 0.0008
2091 Endoplasmin HSP90B1 0.0008
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0007
6316 ADP-ribosylation factor 1 ARF1 0.0007
6134 Sodium channel subunit beta-3 SCN3B 0.0007
6133 Sodium channel subunit beta-2 SCN2B 0.0007
6135 Sodium channel subunit beta-4 SCN4B 0.0007
6132 Sodium channel subunit beta-1 SCN1B 0.0007
6129 Carbonic anhydrase-related protein 11 CA11 0.0007
6127 Carbonic anhydrase-related protein CA8 0.0007
6128 Carbonic anhydrase-related protein 10 CA10 0.0007
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
1830 5'-nucleotidase NT5E 0.0007
1507 Cytochrome c CYCS 0.0007
125 DNA polymerase beta POLB 0.0007
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0006
6130 Carbonic anhydrase 13 CA13 0.0006
4954 Soluble cytochrome b558 Not Available 0.0006
4943 Cytochrome c6 petJ 0.0006
4916 Cyanoglobin glbN 0.0006
5000 HemO hemO 0.0006
4934 Cytochrome c-551 nirM 0.0006
5218 Cytochrome c-551 nirM 0.0006
4947 Bacterial hemoglobin vhb 0.0006
4942 Diheme cytochrome c napB napB 0.0006
4994 Hemoglobin-like protein HbO glbO 0.0006
4981 Iron-starvation protein PigA pigA 0.0006
4984 Neuroglobin NGB 0.0006
4975 Cytochrome c-556 RPA3973 0.0006
4905 Cytochrome c2 Not Available 0.0006
4939 Cytochrome c2 cycA 0.0006
4964 Cytochrome c2 cycA 0.0006
4979 Cytochrome c2 cycA 0.0006
6673 Cytochrome c2 cycA 0.0006
4915 Cytochrome c-550 psbV 0.0006
4959 Cytochrome c-550 psbV 0.0006
5216 Cytochrome c-550 psbV 0.0006
4925 Cytochrome c-type protein SHP shp 0.0006
4935 Cytochrome c-554 cycA1 0.0006
4910 Cytoglobin CYGB 0.0006
4936 Cytochrome c2 iso-2 Not Available 0.0006
4998 Hemoglobin-like protein yjbI yjbI 0.0006
4909 CooA protein cooA 0.0006
4961 Hemophore HasA hasA 0.0006
644 Heme oxygenase 2 HMOX2 0.0006
4982 Heme oxygenase 2 pbsA2 0.0006
4971 Nonaheme cytochrome c hmcA 0.0006
4907 Cytochrome c-L moxG 0.0006
6865 Cytochrome c-L moxG 0.0006
4904 Cytochrome c family protein GSU1996 0.0006
4937 Cytochrome oxidase subunit II rcoxA 0.0006
4931 Cytochrome P450 167A1 CYP167A1 0.0006
4989 Cytochrome c551 peroxidase ccp 0.0006
5222 Cytochrome c551 peroxidase ccpA 0.0006
4976 Apocytochrome f petA 0.0006
6407 Apocytochrome f petA 0.0006
4903 Methyl-accepting chemotaxis protein Tar4 0.0006
4764 Cytochrome P450 165C4 CYP165C4 0.0006
4960 Putative cytochrome P450-family protein SCO7417 0.0006
4922 Cytochrome c, putative SO_4144 0.0006
4926 Heme-based aerotactic transducer hemAT hemAT 0.0006
4999 Cytochrome P450 165B3 CYP165B3 0.0006
4972 P450cin cinA 0.0006
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0006
4993 Hydroxylamine oxidoreductase hao1 0.0006
4952 Catalase/peroxidase katA 0.0006
3093 Catalase HPII katE 0.0006
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0006
5221 Cytochrome c3, 13 kDa Not Available 0.0006
3152 Cytochrome c'' cycA 0.0006
5220 Split-Soret cytochrome c Ddes_2150 0.0006
3700 Cytochrome c-552 precursor nrfA 0.0006
1721 Glycogen synthase kinase-3 beta GSK3B 0.0005
3238 Multidrug resistance protein mexA mexA 0.0005
3116 Bacterioferritin bfr 0.0005
4906 Bacterioferritin bfr 0.0005
4965 Bacterioferritin bfr 0.0005
3173 Enolase eno 0.0005
3709 Glycerol uptake facilitator protein glpF 0.0005
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0005
3393 TGF-beta receptor type-2 TGFBR2 0.0005
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0005
6743 Non-fluorescent flavoprotein luxF 0.0005
6753 Apolipoprotein M APOM 0.0005
2528 Fatty acid metabolism regulator protein fadR 0.0005
6740 Fatty acid metabolism regulator protein fadR 0.0005
6752 Guanylyl cyclase-activating protein 1 GUCA1A 0.0005
394 Calcineurin subunit B isoform 1 PPP3R1 0.0005
6742 Recoverin RCVRN 0.0005
6747 Chalcone/stilbene synthase family protein MT1417 0.0005
6741 Peroxisomal 3,2-trans-enoyl-CoA isomerase PECI 0.0005
6522 Hepatocyte nuclear factor 4-alpha HNF4A 0.0005
6751 Gag polyprotein gag 0.0005
6746 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform PPP3CA 0.0005
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0005
6749 Polyprotein Not Available 0.0005
3127 Nitrite reductase nirS 0.0005
3284 Nitrite reductase nirS 0.0005
2852 DNA mismatch repair protein mutL mutL 0.0005
5961 Insulin INS 0.0005
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0005
6527 Lymphocyte antigen 96 LY96 0.0005
3191 Histidinol dehydrogenase hisD 0.0005
3405 Quinohaemoprotein ethanol dehydrogenase type-1 qheDH 0.0004
6750 ADP-ribosylation factor 6 ARF6 0.0004
4373 Medium-chain-fatty-acid--CoA ligase Not Available 0.0004
4920 Peroxidase/catalase katG 0.0004
4692 A/G-specific adenine glycosylase mutY 0.0004
6524 Protein tonB tonB 0.0004
2119 Cytochrome b5 CYB5A 0.0004
4990 PpcA ppcA 0.0004
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0004
4988 Sulfite oxidase, mitochondrial SUOX 0.0004
3375 Acidic cytochrome c3 Not Available 0.0004
4037 Hypothetical protein GPX1 0.0004
4297 Hypothetical protein SP_1951 0.0004
4521 Hypothetical protein BC_2969 0.0004
4540 Hypothetical protein TM_1070 0.0004
4555 Hypothetical protein MT1739 0.0004
4569 Hypothetical protein mshD 0.0004
4578 Hypothetical protein PA3270 0.0004
4747 Hypothetical protein PA3967 0.0004
5177 Hypothetical protein TM_0096 0.0004
5194 Hypothetical protein PA1204 0.0004
5240 Hypothetical protein Rv2991 0.0004
5370 Hypothetical protein TM_1158 0.0004
5710 Hypothetical protein Tb927.5.1360 0.0004
3570 Cytochrome P450 152A1 cypC 0.0004
2915 Sensor protein fixL fixL 0.0004
4944 Sensor protein fixL fixL 0.0004
4813 Heme oxygenase hmuO 0.0004
5769 Heme oxygenase Not Available 0.0004
4289 Cytochrome P450 TT_P0059 0.0004
6262 Cytochrome P450 staP 0.0004
4992 Cytochrome c peroxidase Not Available 0.0004
4385 Cytochrome c' Not Available 0.0004
4967 Cytochrome c' cycA 0.0004
5038 Cytochrome c' Not Available 0.0004
5223 Cytochrome c' cycP 0.0004
2230 Catalase CAT 0.0004
3249 Catalase katA 0.0004
3625 Catalase katA 0.0004
4539 Catalase katA 0.0004
4941 Catalase katB 0.0004
2435 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase lpxC 0.0004
6613 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase lpxC 0.0004
2802 Endoglucanase G celCCG 0.0004
340 Apoptotic protease-activating factor 1 APAF1 0.0004
2391 Ferrochelatase hemH 0.0004
6502 Ferrochelatase DKFZp686P18130 0.0004
1591 Ferrochelatase, mitochondrial FECH 0.0004
3670 Soluble cytochrome b562 precursor cybC 0.0004
3411 Cytochrome P450 121 cyp121 0.0004
3291 Cytochrome c-552 cycA 0.0004
4927 Cytochrome c-552 nrfA 0.0004
4938 Cytochrome c-552 cycA 0.0004
4953 Cytochrome c-552 nrfA 0.0004
5217 Cytochrome c-552 cycM 0.0004
2617 Nitric oxide synthase oxygenase nos 0.0004
2701 Nitric oxide synthase oxygenase nos 0.0004
3102 Flavohemoprotein hmp 0.0004
4969 Flavohemoprotein hmp 0.0004
864 Gag-Pol polyprotein gag-pol 0.0003
2237 Gag-Pol polyprotein gag-pol 0.0003
2326 Gag-Pol polyprotein gag-pol 0.0003
2451 Gag-Pol polyprotein gag-pol 0.0003
2901 Gag-Pol polyprotein gag-pol 0.0003
3165 Gag-Pol polyprotein gag-pol 0.0003
3722 Gag-Pol polyprotein gag-pol 0.0003
6306 Gag-Pol polyprotein gag-pol 0.0003
6624 Gag-Pol polyprotein gag-pol 0.0003
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0003
825 Arsenical pump-driving ATPase ASNA1 0.0003
3435 Arsenical pump-driving ATPase arsA 0.0003
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0003
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0003
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0003
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0003
733 Activin receptor type 1B ACVR1B 0.0003
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0003
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0003
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0003
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0003
154 AFG3-like protein 2 AFG3L2 0.0003
395 ALK tyrosine kinase receptor Not Available 0.0003
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0003
2972 6-deoxyerythronolide B hydroxylase eryF 0.0003
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0003
6493 Cytochrome c oxidase subunit 6C COX6C 0.0003
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0003
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0003
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0003
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0003
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0003
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0003
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0003
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0003
6559 Cytochrome c oxidase subunit 2 ctaC 0.0003
6669 Cytochrome c oxidase subunit 2 ctaC 0.0003
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0003
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0003
6558 Cytochrome c oxidase subunit 1 ctaD 0.0003
292 Activin receptor type-1 ACVR1 0.0003
849 Activated CDC42 kinase 1 TNK2 0.0003
4608 Putative cytochrome P450 SCO1207 0.0003
4963 Putative cytochrome P450 SCO2884 0.0003
6254 Putative cytochrome P450 SCO6998 0.0003
2540 Choloylglycine hydrolase cbh 0.0003
2427 Ferrichrome-iron receptor fhuA 0.0003
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0003
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0003
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0003
297 Adenylate cyclase type 1 ADCY1 0.0003
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0003
358 Cystathionine beta-synthase CBS 0.0003
6264 cAMP-dependent protein kinase inhibitor alpha PKIA 0.0003
693 Hemoglobin subunit beta HBB 0.0003
6268 Hydroxyacid oxidase 1 HAO1 0.0003
810 Heme oxygenase 1 HMOX1 0.0002
3391 Heme oxygenase 1 pbsA1 0.0002
740 Argininosuccinate synthase ASS1 0.0002
865 Argininosuccinate synthase ASS1 0.0002
2680 Argininosuccinate synthase argG 0.0002
3194 Argininosuccinate synthase argG 0.0002
661 ADP/ATP translocase 1 SLC25A4 0.0002
6021 Adenosine kinase ADK 0.0002
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0002
6500 Phospholipase A2 PLA2G1B 0.0002
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