DT-Web: DB00877

Identification

Name

Sirolimus

Accession Number

DB00877 (APRD00178, DB02439)

Type

small molecule

Description

A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation of cytokines thereby inhibiting cytokine production. It is bioactive only when bound to immunophilins. Sirolimus is a potent immunosuppressant and possesses both antifungal and antineoplastic properties. [PubChem]

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

914.1719

Groups

approved

Monoisotopic Weight

913.555141619

Pharmacology

Indication

For the prophylaxis of organ rejection in patients receiving renal transplants.

Mechanism of action

Sirolimus inhibits T lymphocyte activation and proliferation that occurs in response to antigenic and cytokine (Interleukin IL-2, IL-4, and IL-15) stimulation by a mechanism that is distinct from that of other immunosuppressants. Sirolimus also inhibits antibody production. In cells, sirolimus binds to the immunophilin, FK Binding Protein-12 (FKBP-12), to generate an immunosuppressive complex. The sirolimus:FKBP-12 complex has no effect on calcineurin activity. This complex binds to and inhibits the activation of the mammalian Target Of Rapamycin (mTOR), a key regulatory kinase. This inhibition suppresses cytokine-driven T-cell proliferation, inhibiting the progression from the G1 to the S phase of the cell cycle.

Absorption

Not Available

Protein binding

92%

Biotransformation

Not Available

Route of elimination

Not Available

Toxicity

Not Available

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Atazanavir	Increases the effect and toxicity of immunosuppressant
Boceprevir	Boceprevir increases levels of sirolimus by affecting CYP3A4 metabolism. Concomitant therapy requires close monitoring.
Clarithromycin	The macrolide, clarithromycin, may increase the serum concentration of sirolimus.
Cyclosporine	Increases the effect and toxicity of sirolimus
Diltiazem	Increases the effect and toxicity of sirolimus
Dronedarone	Sirolimus is a CYP3A substrate with a narrow therapeutic index thus concomitant therapy with dronedarone will increase plasma levels of sirolimus. Monitor plasma concentrations and adjust dose accordingly.
Erythromycin	The macrolide, erythromycin, may increase the serum concentration of sirolimus.
Fosphenytoin	The hydantoin decreases sirolimus levels
Itraconazole	Itraconazole may increase the effect and toxicity of sirolimus.
Ketoconazole	Ketoconazole may increase the effect and toxicity of sirolimus.
Phenytoin	The hydantoin decreases sirolimus levels
Rifabutin	The rifamycin decreases the effect of sirolimus
Rifampin	The rifamycin decreases the effect of sirolimus
Rilonacept	results in increased immunosuppressive effects; increases the risk of infection.
Tacrolimus	Sirolimus may decrease the blood concentration of Tacrolimus. Monitor for changes in the therapeutic/toxic effects of Tacrolimus if Sirolimus therapy is initiated, discontinued or altered.
Telithromycin	Telithromycin may reduce clearance of Sirolimus. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Sirolimus if Telithromycin is initiated, discontinued or dose changed.
Tipranavir	Tipranavir may affect the efficacy/toxicity of Sirolimus.
Trandolapril	Increased risk of angioedema. Monitor for signs and symptoms of facial and systemic edema and/or erythema.
Trastuzumab	Trastuzumab may increase the risk of neutropenia and anemia. Monitor closely for signs and symptoms of adverse events.
Voriconazole	Voriconazole may increase the serum concentration of sirolimus likely by inhibition of CYP3A4-mediated metabolism or p-glyprotein transport of sirolimus. Consider alternate therapy or reduce the dose of sirolimus and monitor serum levels during concomitant therapy.

Food Interactions

Not Available

Serine/threonine-protein kinase mTOR
Name	Serine/threonine-protein kinase mTOR
Gene Name	MTOR
Pharmacological action	yes
Actions	inhibitor
References	Dowling RJ, Topisirovic I, Fonseca BD, Sonenberg N: Dissecting the role of mTOR: lessons from mTOR inhibitors. Biochim Biophys Acta. 2010 Mar;1804(3):433-9. Epub 2009 Dec 11. - Pubmed Shuuin T, Karashima H: [Mammalian target of rapamycin, its mode of action and clinical response in metastatic clear cell carcinoma] Gan To Kagaku Ryoho. 2009 Jul;36(7):1076-9. - Pubmed Sehgal SN: Sirolimus: its discovery, biological properties, and mechanism of action. Transplant Proc. 2003 May;35(3 Suppl):7S-14S. - Pubmed Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score	0.6087
FK506-binding protein 1A
Name	FK506-binding protein 1A
Gene Name	FKBP1A
Pharmacological action	yes
Actions	other
References	Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed Sehgal SN: Sirolimus: its discovery, biological properties, and mechanism of action. Transplant Proc. 2003 May;35(3 Suppl):7S-14S. - Pubmed
DTHybrid score	1.4279
Heparin-binding growth factor 2
Name	Heparin-binding growth factor 2
Gene Name	FGF2
Pharmacological action	yes
Actions	other/unknown
References	Sehgal SN: Sirolimus: its discovery, biological properties, and mechanism of action. Transplant Proc. 2003 May;35(3 Suppl):7S-14S. - Pubmed
DTHybrid score	0.6767

Cytochrome P450 3A4
Name	Cytochrome P450 3A4
Gene Name	CYP3A4
Actions	substrate,inhibitor
References	Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed Ekins S, Bravi G, Wikel JH, Wrighton SA: Three-dimensional-quantitative structure activity relationship analysis of cytochrome P-450 3A4 substrates. J Pharmacol Exp Ther. 1999 Oct;291(1):424-33. - Pubmed
DTHybrid score	0.6815
Cytochrome P450 3A5
Name	Cytochrome P450 3A5
Gene Name	CYP3A5
Actions	substrate
References	Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
DTHybrid score	0.4255
Cytochrome P450 3A7
Name	Cytochrome P450 3A7
Gene Name	CYP3A7
Actions	substrate
References	Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
DTHybrid score	0.3532

Multidrug resistance protein 1
Name	Multidrug resistance protein 1
Gene Name	ABCB1
Actions	inhibitor,inducer
References	Schuetz EG, Beck WT, Schuetz JD: Modulators and substrates of P-glycoprotein and cytochrome P4503A coordinately up-regulate these proteins in human colon carcinoma cells. Mol Pharmacol. 1996 Feb;49(2):311-8. - Pubmed Wacher VJ, Silverman JA, Wong S, Tran-Tau P, Chan AO, Chai A, Yu XQ, O'Mahony D, Ramtoola Z: Sirolimus oral absorption in rats is increased by ketoconazole but is not affected by D-alpha-tocopheryl poly(ethylene glycol 1000) succinate. J Pharmacol Exp Ther. 2002 Oct;303(1):308-13. - Pubmed Arceci RJ, Stieglitz K, Bierer BE: Immunosuppressants FK506 and rapamycin function as reversal agents of the multidrug resistance phenotype. Blood. 1992 Sep 15;80(6):1528-36. - Pubmed Nagy H, Goda K, Fenyvesi F, Bacso Z, Szilasi M, Kappelmayer J, Lustyik G, Cianfriglia M, Szabo G Jr: Distinct groups of multidrug resistance modulating agents are distinguished by competition of P-glycoprotein-specific antibodies. Biochem Biophys Res Commun. 2004 Mar 19;315(4):942-9. - Pubmed
DTHybrid score	0.441
Solute carrier organic anion transporter family member 1B1
Name	Solute carrier organic anion transporter family member 1B1
Gene Name	SLCO1B1
Actions	inhibitor
References	Fehrenbach T, Cui Y, Faulstich H, Keppler D: Characterization of the transport of the bicyclic peptide phalloidin by human hepatic transport proteins. Naunyn Schmiedebergs Arch Pharmacol. 2003 Nov;368(5):415-20. Epub 2003 Oct 3. - Pubmed
DTHybrid score	0.2549
Multidrug and toxin extrusion protein 1
Name	Multidrug and toxin extrusion protein 1
Gene Name	SLC47A1
Actions	Not Available
References	Meyer zu Schwabedissen HE, Verstuyft C, Kroemer HK, Becquemont L, Kim RB: Human multidrug and toxin extrusion 1 (MATE1/SLC47A1) transporter: functional characterization, interaction with OCT2 (SLC22A2), and single nucleotide polymorphisms. Am J Physiol Renal Physiol. 2010 Apr;298(4):F997-F1005. Epub 2010 Jan 6. - Pubmed
DTHybrid score	0.2812

Id	Partner name	Gene Name	Score
4119	Cytochrome P450 2D6	CYP2D6	0.2218
2805	Heparan sulfate glucosamine 3-O-sulfotransferase 3A1	HS3ST3A1	0.1682
4757	Cytochrome P450 2C9	CYP2C9	0.1677
6016	Cytochrome P450 2C19	CYP2C19	0.1659
4924	Cytochrome P450 2C8	CYP2C8	0.1593
4200	Cytochrome P450 1A2	CYP1A2	0.1478
760	Fibroblast growth factor 1	FGF1	0.1126
1729	Solute carrier family 22 member 6	SLC22A6	0.1014
587	Serum albumin	ALB	0.0988
6030	Cytochrome P450 2B6	CYP2B6	0.0986
361	Fibroblast growth factor 4	FGF4	0.0986
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.0942
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0855
6145	Solute carrier family 22 member 1	SLC22A1	0.0839
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.0836
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.0796
6013	Cytochrome P450 2E1	CYP2E1	0.0713
492	Histamine H1 receptor	HRH1	0.0713
6024	Cytochrome P450 1A1	CYP1A1	0.0695
292	Activin receptor type-1	ACVR1	0.0653
6142	Solute carrier family 22 member 8	SLC22A8	0.0596
1943	Hepatocyte growth factor	HGF	0.0584
862	Multidrug resistance-associated protein 1	ABCC1	0.0579
6144	Solute carrier family 22 member 2	SLC22A2	0.0564
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.054
2654	Complement control protein	C3L	0.0533
1181	Alpha-1-acid glycoprotein 1	ORM1	0.0499
6147	Solute carrier family 22 member 3	SLC22A3	0.0472
281	5'-AMP-activated protein kinase subunit beta-1	PRKAB1	0.0462
5718	Cytochrome P450 2A6	CYP2A6	0.0449
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0447
776	Bile salt export pump	ABCB11	0.0436
3812	Fibrinogen beta chain [Contains: Fibrinopeptide B]	FGB	0.0407
3813	Fibrinogen gamma chain	FGG	0.0407
595	Fibrinogen alpha chain	FGA	0.0385
1278	Pro-epidermal growth factor	EGF	0.0378
871	Glucocorticoid receptor	NR3C1	0.0365
118	Organic cation/carnitine transporter 2	SLC22A5	0.0362
847	Mu-type opioid receptor	OPRM1	0.0347
20	Prostaglandin G/H synthase 1	PTGS1	0.0341
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0328
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0319
6231	Pepsin A	PGA3	0.0319
6143	Solute carrier family 22 member 7	SLC22A7	0.0305
824	Sodium-dependent serotonin transporter	SLC6A4	0.03
6106	Cytochrome P450 2C18	CYP2C18	0.03
6031	Cytochrome P450 3A43	CYP3A43	0.0298
3811	Cytochrome P450 19A1	CYP19A1	0.0297
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0287
731	HIV-1 protease	HIV-1 protease	0.0286
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0283
556	Alpha-1A adrenergic receptor	ADRA1A	0.0279
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0278
1898	Cytochrome P450 1B1	CYP1B1	0.0278
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0277
831	D(2) dopamine receptor	DRD2	0.0277
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0262
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0254
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0252
2164	Multidrug resistance-associated protein 4	ABCC4	0.0251
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.025
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.025
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.0247
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0245
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0244
467	Delta-type opioid receptor	OPRD1	0.0242
338	DNA polymerase	UL30	0.024
379	DNA polymerase	UL54	0.024
697	DNA polymerase	ORF28	0.024
2482	DNA polymerase	43	0.024
4104	DNA polymerase	BALF5	0.024
136	Estrogen receptor	ESR1	0.0229
833	Organic cation/carnitine transporter 1	SLC22A4	0.0227
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0224
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0222
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0216
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0212
6148	Multidrug resistance-associated protein 7	ABCC10	0.021
696	Kappa-type opioid receptor	OPRK1	0.0209
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0208
614	Progesterone receptor	PGR	0.0202
1024	Solute carrier family 22 member 11	SLC22A11	0.0198
318	Alpha-2A adrenergic receptor	ADRA2A	0.0195
509	Thymidine kinase	TK	0.0195
570	Thymidine kinase	TK	0.0195
2559	Thymidine kinase	TK	0.0195
3430	Thymidine kinase	tdk	0.0195
3518	Thymidine kinase	TK	0.0195
5301	Thymidine kinase	tdk	0.0195
5771	Thymidine kinase	ORF36	0.0195
7009	Thymidine kinase	ORF36	0.0195
260	Cytochrome P450 51	ERG11	0.0194
761	Cytochrome P450 51	ERG11	0.0194
3163	Cytochrome P450 51	cyp51	0.0194
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0194
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0193
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0191
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0191
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0189
6182	Cytochrome P450 2J2	CYP2J2	0.0189
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0185
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0183
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0183
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0183
51	Muscarinic acetylcholine receptor M3	CHRM3	0.018
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.018
632	Alpha-1B adrenergic receptor	ADRA1B	0.0179
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0178
638	D(3) dopamine receptor	DRD3	0.0177
817	DNA topoisomerase 2-alpha	TOP2A	0.0176
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0176
70	Type-1 angiotensin II receptor	AGTR1	0.0176
6141	Sodium/bile acid cotransporter	SLC10A1	0.0174
766	Beta-2 adrenergic receptor	ADRB2	0.0172
737	Mineralocorticoid receptor	NR3C2	0.0169
4604	Liver carboxylesterase 1	CES1	0.0167
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0165
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0164
23	D(1A) dopamine receptor	DRD1	0.0163
3923	Cholinesterase	BCHE	0.016
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0159
193	Beta-1 adrenergic receptor	ADRB1	0.0155
232	Corticosteroid-binding globulin	SERPINA6	0.0154
26	Vascular endothelial growth factor receptor 3	FLT4	0.0154
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0153
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.0152
590	5-hydroxytryptamine 2C receptor	HTR2C	0.015
32	Vascular endothelial growth factor receptor 1	FLT1	0.0147
124	Histamine H2 receptor	HRH2	0.0147
29	Tubulin beta-1 chain	TUBB1	0.0144
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0142
468	Cytochrome P450 4A11	CYP4A11	0.0142
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0141
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0141
543	Penicillin-binding protein 1B	mrcB	0.014
6186	Penicillin-binding protein 1B	ponB	0.014
6822	Penicillin-binding protein 1b	pbp1b	0.014
6844	Penicillin-binding protein 1b	pbp1b	0.014
756	Sex hormone-binding globulin	SHBG	0.0139
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0139
407	Vascular endothelial growth factor receptor 2	KDR	0.0139
159	Penicillin-binding protein 2B	penA	0.0139
6121	Penicillin-binding protein 2B	penA	0.0139
290	Prostaglandin G/H synthase 2	PTGS2	0.0135
713	Sodium-dependent dopamine transporter	SLC6A3	0.0131
504	Mast/stem cell growth factor receptor	KIT	0.013
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.013
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.013
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0129
844	Epidermal growth factor receptor	EGFR	0.0128
465	Calmodulin	CALM1	0.0128
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0127
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.0126
3587	Gastrotropin	FABP6	0.0124
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0124
818	50S ribosomal protein L10	rplJ	0.0122
378	Alpha-2C adrenergic receptor	ADRA2C	0.0121
789	Alpha-1D adrenergic receptor	ADRA1D	0.012
629	Alpha-2B adrenergic receptor	ADRA2B	0.0119
758	Thyroid hormone receptor alpha	THRA	0.0117
811	Translocator protein	TSPO	0.0116
642	3-oxo-5-alpha-steroid 4-dehydrogenase 2	SRD5A2	0.0115
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0114
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.0114
2539	Tubulin alpha-1 chain	TUBA4A	0.0111
477	DNA topoisomerase 4 subunit A	parC	0.0109
886	DNA topoisomerase 4 subunit A	parC	0.0109
6226	DNA topoisomerase 4 subunit A	parC	0.0109
952	Dipeptidyl peptidase 4	DPP4	0.0109
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0109
6136	Multidrug resistance-associated protein 5	ABCC5	0.0108
404	DNA gyrase subunit A	gyrA	0.0108
6224	DNA gyrase subunit A	gyrA	0.0108
346	Thyroid hormone receptor beta-1	THRB	0.0104
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0103
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0101
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.01
3941	Amine oxidase [flavin-containing] A	MAOA	0.01
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.01
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.01
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0099
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0099
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0099
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0098
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0098
1353	DNA topoisomerase 1	TOP1	0.0098
3552	DNA topoisomerase 1	topA	0.0098
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0097
738	Monocarboxylate transporter 1	SLC16A1	0.0097
432	D(4) dopamine receptor	DRD4	0.0096
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0095
4237	50S ribosomal protein L22	rplV	0.0095
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0095
6137	Multidrug resistance-associated protein 6	ABCC6	0.0095
161	Tubulin beta chain	TUBB	0.0095
312	Tubulin beta chain	TUB2	0.0095
4120	NADPH--cytochrome P450 reductase	POR	0.0093
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0092
716	5-hydroxytryptamine 7 receptor	HTR7	0.0091
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.009
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0088
869	Estrogen receptor beta	ESR2	0.0088
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0088
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0088
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0088
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0088
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0088
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0087
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0087
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0087
723	Cytosolic phospholipase A2	PLA2G4A	0.0087
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0086
6020	Aldehyde oxidase	AOX1	0.0085
122	P2Y purinoceptor 12	P2RY12	0.0084
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0084
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0084
146	Androgen receptor	AR	0.0084
594	Thyroxine-binding globulin	SERPINA7	0.0083
380	Cytochrome P450 17A1	CYP17A1	0.0083
4238	50S ribosomal protein L4	rplD	0.0083
5578	50S ribosomal protein L4	rplD	0.0083
6173	50S ribosomal protein L4	rplD	0.0083
6219	50S ribosomal protein L4	rplD	0.0083
6220	Aryl hydrocarbon receptor	AHR	0.0083
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0082
373	Transthyretin	TTR	0.0082
5880	Thrombopoietin receptor	MPL	0.0081
1852	Microtubule-associated protein 2	MAP2	0.0079
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0079
6167	Organic solute transporter subunit beta	OSTB	0.0079
6166	Organic solute transporter subunit alpha	OSTA	0.0079
275	Arachidonate 5-lipoxygenase	ALOX5	0.0079
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0078
777	Tumor necrosis factor	TNF	0.0078
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0077
2616	Ganglioside GM2 activator	GM2A	0.0076
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0075
427	Substance-P receptor	TACR1	0.0074
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0073
1192	Sulfotransferase 1A1	SULT1A1	0.0073
1656	CYP2B protein	CYP2B	0.0073
474	Acetylcholinesterase	ACHE	0.0073
1010	Cytochrome P450 51A1	CYP51A1	0.0073
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0072
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.007
244	Angiotensin-converting enzyme	ACE	0.0068
6085	Fatty acid-binding protein, intestinal	FABP2	0.0068
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0068
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0067
165	FL cytokine receptor	FLT3	0.0067
705	Glutamate receptor 1	GRIA1	0.0067
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0067
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0066
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0066
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0066
3947	Xanthine dehydrogenase/oxidase	XDH	0.0066
3432	Multidrug-efflux transporter 1 regulator	bmrR	0.0063
4476	Mannitol dehydrogenase	mtlD	0.0063
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0063
6105	3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	0.0062
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0062
3939	Amine oxidase [flavin-containing] B	MAOB	0.0062
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0062
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0062
814	Ryanodine receptor 1	RYR1	0.0061
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.006
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.006
208	DNA-directed RNA polymerase beta' chain	rpoC	0.006
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.006
185	Vasopressin V1a receptor	AVPR1A	0.006
1630	Integrin beta-2	ITGB2	0.0059
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0059
469	Annexin A1	ANXA1	0.0059
5923	Microtubule-associated protein tau	MAPT	0.0059
5924	Microtubule-associated protein 4	MAP4	0.0059
322	Vasopressin V2 receptor	AVPR2	0.0058
239	Coagulation factor X	F10	0.0058
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0057
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0057
284	DNA-directed RNA polymerase beta chain	rpoB	0.0056
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0056
2449	Tubulin alpha-3 chain	TUBA1A	0.0056
94	5-hydroxytryptamine 4 receptor	HTR4	0.0056
33	Cystine/glutamate transporter	SLC7A11	0.0056
273	Apoptosis regulator Bcl-2	BCL2	0.0056
319	Opioid receptor, sigma 1	OPRS1	0.0054
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0053
3856	Fibroblast growth factor receptor 3	FGFR3	0.0053
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0053
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0053
163	D(1B) dopamine receptor	DRD5	0.0052
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0051
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0051
5300	Antigen peptide transporter 1	TAP1	0.0051
4122	Histone deacetylase 2	HDAC2	0.0051
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0051
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0051
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0051
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0051
2499	Tubulin beta-2C chain	TUBB2C	0.0051
3809	Estrogen-related receptor gamma	ESRRG	0.0049
6755	Poliovirus receptor	PVR	0.0049
199	Monocarboxylate transporter 8	SLC16A2	0.0048
1483	Membrane copper amine oxidase	AOC3	0.0048
6044	Serum paraoxonase/lactonase 3	PON3	0.0048
4773	Deoxycytidine kinase	DCK	0.0048
683	Potassium transporter	GK0582	0.0047
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0046
1770	Phospholipase C	PLCL1	0.0046
2841	Phospholipase C	plc	0.0046
1760	Aminopeptidase N	ANPEP	0.0046
6843	Aminopeptidase N	pepN	0.0046
1050	Bile salt sulfotransferase	SULT2A1	0.0045
68	Cannabinoid receptor 1	CNR1	0.0045
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0045
54	Prothrombin	F2	0.0045
572	Integrin alpha-L	ITGAL	0.0045
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0044
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0044
563	Thyroid peroxidase	TPO	0.0044
117	Sterol O-acyltransferase 1	SOAT1	0.0044
1178	Adenosine A2a receptor	ADORA2A	0.0044
1517	Beta-3 adrenergic receptor	ADRB3	0.0043
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0043
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0043
6138	Multidrug resistance protein 3	ABCB4	0.0043
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0043
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0042
6102	Arylamine N-acetyltransferase 2	NAT2	0.0042
4210	Toll-like receptor 4	TLR4	0.0042
1196	Complement decay-accelerating factor	CD55	0.0042
1757	Myeloperoxidase	MPO	0.0042
3932	Glutathione S-transferase A2	GSTA2	0.0041
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0041
295	Carbonic anhydrase 1	CA1	0.0041
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0041
84	Nuclear receptor 0B1	NR0B1	0.0041
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0041
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.004
2268	Cholesterol oxidase	choB	0.0039
2822	Cholesterol oxidase	choA	0.0039
394	Calcineurin subunit B isoform 1	PPP3R1	0.0039
6743	Non-fluorescent flavoprotein	luxF	0.0039
6522	Hepatocyte nuclear factor 4-alpha	HNF4A	0.0039
6753	Apolipoprotein M	APOM	0.0039
6742	Recoverin	RCVRN	0.0039
6752	Guanylyl cyclase-activating protein 1	GUCA1A	0.0039
6741	Peroxisomal 3,2-trans-enoyl-CoA isomerase	PECI	0.0039
2528	Fatty acid metabolism regulator protein	fadR	0.0039
6740	Fatty acid metabolism regulator protein	fadR	0.0039
6746	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	PPP3CA	0.0039
6747	Chalcone/stilbene synthase family protein	MT1417	0.0039
6751	Gag polyprotein	gag	0.0039
6749	Polyprotein	Not Available	0.0039
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0039
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0039
1129	C-C chemokine receptor type 5	CCR5	0.0039
2297	Genome polyprotein	Not Available	0.0039
2322	Genome polyprotein	Not Available	0.0039
2694	Genome polyprotein	Not Available	0.0039
2719	Genome polyprotein	Not Available	0.0039
2860	Genome polyprotein	Not Available	0.0039
2928	Genome polyprotein	Not Available	0.0039
3160	Genome polyprotein	Not Available	0.0039
3260	Genome polyprotein	Not Available	0.0039
4783	Genome polyprotein	Not Available	0.0039
5726	Genome polyprotein	Not Available	0.0039
5779	Genome polyprotein	Not Available	0.0039
5867	Genome polyprotein	Not Available	0.0039
6253	Genome polyprotein	Not Available	0.0039
6301	Genome polyprotein	Not Available	0.0039
6380	Genome polyprotein	Not Available	0.0039
6381	Genome polyprotein	Not Available	0.0039
6437	Genome polyprotein	Not Available	0.0039
6520	Genome polyprotein	Not Available	0.0039
6521	Genome polyprotein	Not Available	0.0039
6652	Genome polyprotein	Not Available	0.0039
6734	Genome polyprotein	Not Available	0.0039
6735	Genome polyprotein	Not Available	0.0039
6736	Genome polyprotein	Not Available	0.0039
6737	Genome polyprotein	Not Available	0.0039
6738	Genome polyprotein	Not Available	0.0039
6739	Genome polyprotein	Not Available	0.0039
6744	Genome polyprotein	Not Available	0.0039
6748	Genome polyprotein	Not Available	0.0039
6894	Genome polyprotein	Not Available	0.0039
6898	Genome polyprotein	Not Available	0.0039
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0038
267	Plasminogen activator inhibitor 1	SERPINE1	0.0038
5432	Trafficking protein particle complex subunit 3	TRAPPC3	0.0038
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0038
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0037
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0037
2283	Steroid Delta-isomerase	ksi	0.0037
2920	Steroid Delta-isomerase	ksi	0.0037
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0036
6014	Cytochrome P450 2A13	CYP2A13	0.0036
2808	Chloramphenicol acetyltransferase 3	cat3	0.0036
1618	High affinity nerve growth factor receptor	NTRK1	0.0036
2112	Toll-like receptor 9	TLR9	0.0036
4203	Histamine N-methyltransferase	HNMT	0.0036
16	Adenosine A1 receptor	ADORA1	0.0036
24	Thymidylate synthase	TMP1	0.0035
359	Thymidylate synthase	TYMS	0.0035
2626	Thymidylate synthase	thyA	0.0035
2729	Thymidylate synthase	thyA	0.0035
5352	Thymidylate synthase	THYA	0.0035
856	Vitamin D3 receptor	VDR	0.0035
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0035
780	Retinoic acid receptor RXR-gamma	RXRG	0.0035
939	50S ribosomal protein L3	rplC	0.0035
976	Platelet glycoprotein IX	GP9	0.0034
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0034
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0034
6221	Steroid hormone receptor ERR1	ESRRA	0.0034
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0034
6527	Lymphocyte antigen 96	LY96	0.0034
5961	Insulin	INS	0.0034
131	Synaptic vesicular amine transporter	SLC18A2	0.0034
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0034
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0033
6824	Tyrosine-protein kinase Lyn	LYN	0.0033
6043	Putative G-protein coupled receptor 44	GPR44	0.0033
3601	Dihydropteroate synthase 1	folP1	0.0033
3807	Dihydropteroate synthase 1	folP1	0.0033
3808	Dihydropteroate synthase 2	folP2	0.0033
2417	Chloramphenicol acetyltransferase	cat	0.0033
3278	Chloramphenicol acetyltransferase	cat	0.0033
823	Fibroblast growth factor receptor 2	FGFR2	0.0033
6149	Solute carrier family 22 member 10	SLC22A10	0.0033
6151	Monocarboxylate transporter 10	SLC16A10	0.0033
2810	Dr hemagglutinin structural subunit	draA	0.0032
6174	50S ribosomal protein L32	rpmF	0.0032
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0032
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0032
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0032
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0032
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0032
592	Carbonic anhydrase 4	CA4	0.0032
3086	Plasmepsin-2	Not Available	0.0032
88	Retinoic acid receptor RXR-beta	RXRB	0.0032
365	Dihydrofolate reductase	DHFR	0.0032
2381	Dihydrofolate reductase	DFR1	0.0032
2833	Dihydrofolate reductase	Not Available	0.0032
2931	Dihydrofolate reductase	folA	0.0032
3544	Dihydrofolate reductase	folA	0.0032
3682	Dihydrofolate reductase	folA	0.0032
6642	Dihydrofolate reductase	folA	0.0032
6756	Dihydrofolate reductase	dfrA	0.0032
2107	Microtubule-associated protein 1A	MAP1A	0.0032
6168	Solute carrier family 22 member 16	SLC22A16	0.0031
6750	ADP-ribosylation factor 6	ARF6	0.0031
140	30S ribosomal protein S9	rpsI	0.0031
6719	30S ribosomal protein S9	rpsI	0.0031
6725	30S ribosomal protein S9	rpsI	0.0031
4373	Medium-chain-fatty-acid--CoA ligase	Not Available	0.0031
6524	Protein tonB	tonB	0.0031
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0031
904	Glutathione S-transferase P	GSTP1	0.0031
153	Dopamine beta-hydroxylase	DBH	0.0031
3913	Glutamic acid decarboxylase	GAD65	0.0031
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0031
751	Potassium channel subfamily K member 6	KCNK6	0.0031
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0031
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0031
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0031
174	Sigma 1-type opioid receptor	SIGMAR1	0.003
2578	Tubulin beta-3 chain	TUBB3	0.003
2285	Streptogramin A acetyltransferase	vatD	0.003
6316	ADP-ribosylation factor 1	ARF1	0.003
4192	DNA topoisomerase 2-beta	TOP2B	0.003
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.003
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.003
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.003
6048	Troponin C, skeletal muscle	TNNC2	0.003
636	Mitochondrial carnitine/acylcarnitine carrier protein	SLC25A20	0.0029
109	Mitochondrial carnitine/acylcarnitine carrier protein CACL	SLC25A29	0.0029
1629	Transcription factor AP-1	JUN	0.0029
172	Potassium channel subfamily K member 1	KCNK1	0.0028
2435	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase	lpxC	0.0028
6613	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase	lpxC	0.0028
1435	Synaptic vesicle glycoprotein 2A	SV2A	0.0028
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0028
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0028
4103	Proteasome subunit beta type 2	PSMB2	0.0027
4102	Proteasome subunit beta type 5	PSMB5	0.0027
4101	Proteasome subunit beta type 1	PSMB1	0.0027
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0027
6232	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	GNAS	0.0027
6233	Adenylate cyclase type 2	ADCY2	0.0027
6234	Adenylate cyclase type 5	ADCY5	0.0027
4311	tRNA	TRDMT1	0.0027
4325	tRNA	trmD	0.0027
4328	tRNA	trmD	0.0027
6228	Nuclear receptor coactivator 1	NCOA1	0.0027
4173	Tyrosine-protein kinase JAK2	JAK2	0.0027
6432	Transporter	snf	0.0027
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0026
1650	Heme carrier protein 1	SLC46A1	0.0026
5787	Angiopoietin-1 receptor	TEK	0.0026
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0026
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0026
3904	Alanine aminotransferase 2	GPT2	0.0026
735	Alanine aminotransferase 1	GPT	0.0026
6599	HTH-type transcriptional regulator ttgR	ttgR	0.0026
5997	Tumor necrosis factor ligand superfamily member 11	TNFSF11	0.0026
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0026
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0026
49	Endothelin B receptor	EDNRB	0.0026
412	Peroxisomal carnitine O-octanoyltransferase	CROT	0.0026
551	Carnitine O-acetyltransferase	CRAT	0.0025
1385	Angiotensin-converting enzyme 2	ACE2	0.0025
1864	RET proto-oncogene	RET	0.0025
864	Gag-Pol polyprotein	gag-pol	0.0025
2237	Gag-Pol polyprotein	gag-pol	0.0025
2326	Gag-Pol polyprotein	gag-pol	0.0025
2451	Gag-Pol polyprotein	gag-pol	0.0025
2901	Gag-Pol polyprotein	gag-pol	0.0025
3165	Gag-Pol polyprotein	gag-pol	0.0025
3722	Gag-Pol polyprotein	gag-pol	0.0025
6306	Gag-Pol polyprotein	gag-pol	0.0025
6624	Gag-Pol polyprotein	gag-pol	0.0025
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0025
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0025
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0025
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0024
605	Fumarate reductase flavoprotein subunit	frdA	0.0024
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0024
3673	Fumarate reductase flavoprotein subunit	fccA	0.0024
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0024
6549	Fumarate reductase flavoprotein subunit	frdA	0.0024
578	Endothelin-1 receptor	EDNRA	0.0024
544	Potassium voltage-gated channel subfamily E member 1	KCNE1	0.0024
357	Carbonic anhydrase 2	CA2	0.0024
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0024
233	Potassium channel subfamily K member 2	KCNK2	0.0024
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0024
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0024
719	Retinoic acid receptor responder protein 1	RARRES1	0.0024
5852	Type-2 angiotensin II receptor	AGTR2	0.0024
770	Retinoic acid-induced protein 3	GPRC5A	0.0024
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0024
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0023
936	Ephrin type-A receptor 2	EPHA2	0.0023
4221	Vascular endothelial growth factor	VEGF	0.0023
5816	Cadherin-5	CDH5	0.0023
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0023
3810	Catechol O-methyltransferase	COMT	0.0023
5934	Cytochrome P450 26A1	CYP26A1	0.0023
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0023
2599	Tyrosine-protein kinase HCK	HCK	0.0022
162	Retinoic acid receptor gamma-1	RARG	0.0022
2427	Ferrichrome-iron receptor	fhuA	0.0022
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.0022
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0022
298	Renin	REN	0.0021
6506	Stathmin-4	STMN4	0.0021
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0021
569	Retinal dehydrogenase 2	ALDH1A2	0.0021
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0021
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.0021
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.002
1063	Signal transducer and activator of transcription 5B	STAT5B	0.002
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.002
2216	Fibroblast growth factor receptor 4	FGFR4	0.002
921	Glutamate receptor 2	GRIA2	0.002
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.002
6264	cAMP-dependent protein kinase inhibitor alpha	PKIA	0.002
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.002
7	Nitric oxide synthase, inducible	NOS2	0.002
611	Retinal dehydrogenase 1	ALDH1A1	0.0019
633	Penicillin-binding proteins 1A/1B	pbpA	0.0019
484	Tyrosine-protein kinase ABL2	ABL2	0.0019
461	Glycine receptor subunit alpha-3	GLRA3	0.0019
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.0019
6263	cAMP-dependent protein kinase catalytic subunit alpha	PRKACA	0.0018
5998	Toll-like receptor 8	TLR8	0.0018
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0018
712	Tubulin alpha chain	TUB1	0.0018
1968	ATP-sensitive inward rectifier potassium channel 12	KCNJ12	0.0018
565	Extracellular calcium-sensing receptor	CASR	0.0018
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0018
5818	Folate receptor alpha	FOLR1	0.0018
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0017
613	Atrial natriuretic peptide receptor A	NPR1	0.0017
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0017
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0017
2391	Ferrochelatase	hemH	0.0017
6502	Ferrochelatase	DKFZp686P18130	0.0017
1591	Ferrochelatase, mitochondrial	FECH	0.0017
908	Glutathione S-transferase theta-1	GSTT1	0.0017
144	Hemoglobin subunit alpha	HBA1	0.0017
459	Retinoic acid receptor RXR-alpha	RXRA	0.0017
106	Cannabinoid receptor 2	CNR2	0.0016
78	Acetyl-CoA acetyltransferase, mitochondrial	ACAT1	0.0016
6766	O-GlcNAcase BT_4395	BT_4395	0.0016
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0016
173	Toll-like receptor 7	TLR7	0.0016
3233	Bile acid receptor	NR1H4	0.0015
293	Gamma-glutamyl hydrolase	GGH	0.0015
702	UMP-CMP kinase	CMPK1	0.0015
6495	Cytochrome c oxidase subunit 7C, mitochondrial	COX7C	0.0015
6499	Cytochrome c oxidase polypeptide 7A1, mitochondrial	COX7A1	0.0015
6496	Cytochrome c oxidase subunit 8A, mitochondrial	COX8A	0.0015
6493	Cytochrome c oxidase subunit 6C	COX6C	0.0015
6494	Cytochrome c oxidase subunit 7B, mitochondrial	COX7B	0.0015
6491	Cytochrome c oxidase subunit 5A, mitochondrial	COX5A	0.0015
6498	Cytochrome c oxidase subunit 6B1	COX6B1	0.0015
6497	Cytochrome c oxidase subunit 6A2, mitochondrial	COX6A2	0.0015
6489	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	COX4I1	0.0015
3611	Cytidine deaminase	cdd	0.0015
3707	Cytidine deaminase	cdd	0.0015
4211	Cytidine deaminase	CDA	0.0015
5793	Cytochrome c oxidase subunit 2	MT-CO2	0.0015
6559	Cytochrome c oxidase subunit 2	ctaC	0.0015
6669	Cytochrome c oxidase subunit 2	ctaC	0.0015
6490	Cytochrome c oxidase subunit 3	MT-CO3	0.0015
371	Cytochrome c oxidase subunit 1	MT-CO1	0.0015
6558	Cytochrome c oxidase subunit 1	ctaD	0.0015
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.0015
1291	cAMP response element-binding protein	CREB1	0.0015
581	Cytochrome P450 2R1	CYP2R1	0.0015
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0015
1569	G1/S-specific cyclin-D1	CCND1	0.0015
1541	Metalloproteinase	mmp20	0.0014
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0014
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0014
2129	Sucrase-isomaltase, intestinal	SI	0.0014
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0014
1262	Corticotropin-lipotropin	POMC	0.0014
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.0014
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0014
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0014
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.0014
183	Vascular endothelial growth factor A	VEGFA	0.0014
2540	Choloylglycine hydrolase	cbh	0.0014
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0014
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0013
6211	Tubulin epsilon chain	TUBE1	0.0013
6212	Tubulin gamma-1 chain	TUBG1	0.0013
6210	Tubulin delta chain	TUBD1	0.0013
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0013
6501	Fatty acid-binding protein, liver	FABP1	0.0013
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0013
891	Dihydropteroate synthase	folP	0.0013
5359	Dihydropteroate synthase	folP	0.0013
7175	Dihydropteroate synthase	sulI	0.0013
6116	Gastric triacylglycerol lipase	LIPF	0.0012
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.0012
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0012
3382	Glycolipid transfer protein	GLTP	0.0012
517	Alcohol dehydrogenase 1C	ADH1C	0.0012
694	Matrix protein 2	M	0.0012
2240	Cell division protein kinase 2	CDK2	0.0012
3823	Cytokine receptor common gamma chain	IL2RG	0.0012
85	Growth hormone receptor	GHR	0.0012
6126	Carbonic anhydrase 7	CA7	0.0012
1714	Mitogen-activated protein kinase 3	MAPK3	0.0012
571	Melatonin receptor type 1A	MTNR1A	0.0012
362	Melatonin receptor type 1B	MTNR1B	0.0012
1295	Fatty acid synthase	FASN	0.0012
3957	Adenosine deaminase	ADA	0.0012
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0012
482	Glycine receptor subunit alpha-1	GLRA1	0.0012
6859	Protein S100-A4	S100A4	0.0012
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0011
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0011
707	72 kDa type IV collagenase	MMP2	0.0011
754	Pancreatic triacylglycerol lipase	PNLIP	0.0011
2300	Lysozyme	E	0.0011
3633	Lysozyme	R	0.0011
5597	Lysozyme	17	0.0011
6459	Glycodelin	PAEP	0.0011
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0011
6500	Phospholipase A2	PLA2G1B	0.0011
2178	Metabotropic glutamate receptor 5	GRM5	0.0011
896	Glutathione S-transferase Mu 1	GSTM1	0.0011
724	Interleukin-2 receptor alpha chain	IL2RA	0.0011
717	Interleukin-2 receptor subunit beta	IL2RB	0.0011
1374	Natriuretic peptides B	NPPB	0.001
1827	Gap junction alpha-1 protein	GJA1	0.001
1908	Vascular cell adhesion protein 1	VCAM1	0.001
1810	Protein S100-A1	S100A1	0.001
6097	Protein S100-A2	S100A2	0.001
4116	Dihydropteroate synthetase	Not Available	0.001
4228	Keratin, type II cytoskeletal 7	KRT7	0.001
4217	Telomerase reverse transcriptase	TERT	0.001
1144	Hepatocyte growth factor receptor	MET	0.001
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.001
493	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	0.001
2404	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PIK3CG	0.001
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.001
512	DNA-directed RNA polymerase alpha chain	rpoA	0.001
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.001
4041	Microsomal glutathione S-transferase 2	MGST2	0.001
1176	Mitogen-activated protein kinase 1	MAPK1	0.001
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.001
2473	Tyrosine-protein kinase CSK	CSK	0.001
2398	Tyrosine-protein kinase ZAP-70	ZAP70	0.001
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.001
65	Matrix metalloproteinase-9	Not Available	0.001
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0009
1039	Histone deacetylase 9	HDAC9	0.0009
164	Histamine H4 receptor	HRH4	0.0009
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0009
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0009
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.0009
1048	Protein S100-A13	S100A13	0.0009
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0009
2226	Protein S100-A12	S100A12	0.0009
1648	Elastin	ELN	0.0009
2347	Proto-oncogene serine/threonine-protein kinase Pim-1	PIM1	0.0009
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0009
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0009
6131	Carbonic anhydrase 14	CA14	0.0009
992	Protein tyrosine kinase 2 beta	PTK2B	0.0009
390	Adenosine A3 receptor	ADORA3	0.0009
6171	Solute carrier family 28 member 3	SLC28A3	0.0009
2132	Protein S100-B	S100B	0.0009
489	Monocarboxylate transporter 2	SLC16A7	0.0009
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0008
3404	Exotoxin A	eta	0.0008
22	30S ribosomal protein S4	rpsD	0.0008
6714	30S ribosomal protein S4	rpsD	0.0008
6122	Carbonic anhydrase 3	CA3	0.0008
3616	Fatty acid-binding protein, epidermal	FABP5	0.0008
5433	UPF0230 protein TM_1468	TM_1468	0.0008
5430	Hepatocyte nuclear factor 4-gamma	HNF4G	0.0008
5431	Lipid binding protein	Not Available	0.0008
5798	Mitogen-activated protein kinase 11	MAPK11	0.0008
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0008
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0008
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0008
2320	Thymidine kinase, cytosolic	TK1	0.0008
229	Retinoic acid receptor beta	RARB	0.0008
1867	Major prion protein	PRNP	0.0008
2232	Interleukin-5	IL5	0.0008
1593	Mucin-2	MUC2	0.0008
4031	Glutathione S-transferase A1	GSTA1	0.0008
730	Retinoic acid receptor alpha	RARA	0.0008
1649	Small inducible cytokine A2	CCL2	0.0008
2530	Protein kinase C theta type	PRKCQ	0.0008
1025	Aquaporin-1	AQP1	0.0008
1275	Estrogen sulfotransferase	SULT1E1	0.0008
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0008
2091	Endoplasmin	HSP90B1	0.0008
291	Nitric-oxide synthase, endothelial	NOS3	0.0008
473	L-lactate dehydrogenase A chain	LDHA	0.0007
6146	High affinity copper uptake protein 1	SLC31A1	0.0007
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0007
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0007
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0007
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0007
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0007
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0007
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0007
130	Prostacyclin synthase	PTGIS	0.0007
6103	Arylamine N-acetyltransferase 1	NAT1	0.0007
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0007
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0007
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.0007
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0007
2207	Rhodopsin	RHO	0.0007
6218	Pannexin-1	PANX1	0.0007
6207	30S ribosomal protein S14	rpsN	0.0007
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0007
6209	30S ribosomal protein S19	rpsS	0.0007
6712	30S ribosomal protein S19	rpsS	0.0007
6726	30S ribosomal protein S19	rpsS	0.0007
283	SEC14-like protein 2	SEC14L2	0.0007
645	Penicillin-binding protein 1A	mrcA	0.0007
5805	Penicillin-binding protein 1A	ponA	0.0007
6185	Penicillin-binding protein 1A	mrcA	0.0007
6799	Penicillin-binding protein 1A	pbpA	0.0007
2408	Tyrosine-protein kinase SYK	SYK	0.0007
2511	MAP kinase-activated protein kinase 2	MAPKAPK2	0.0007
2298	Cytochrome P450-cam	camC	0.0007
518	Peroxidase/catalase T	katG	0.0007
2290	ADP-ribosyl cyclase 2	BST1	0.0007
226	Gonadotropin-releasing hormone receptor	GNRHR	0.0007
1830	5'-nucleotidase	NT5E	0.0007
6836	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	HIBCH	0.0007
6837	Serine/threonine-protein kinase 17B	STK17B	0.0007
444	Alcohol dehydrogenase 1B	ADH1B	0.0007
125	DNA polymerase beta	POLB	0.0007
2211	Fatty acid-binding protein, heart	FABP3	0.0007
1123	Eosinophil cationic protein	RNASE3	0.0007
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0007
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0006
3937	Fatty-acid amide hydrolase	FAAH	0.0006
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0006
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0006
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0006
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0006
6677	Myelin P2 protein	PMP2	0.0006
6241	Nuclear receptor coactivator 2	NCOA2	0.0006
342	P protein [Includes: DNA-directed DNA polymerase	P	0.0006
612	P protein [Includes: DNA-directed DNA polymerase	P	0.0006
677	Choline-phosphate cytidylyltransferase A	PCYT1A	0.0006
3426	Glutamine synthetase	glnA	0.0006
3987	Glutamine synthetase	GLUL	0.0006
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0006
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0006
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0006
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0006
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0006
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0006
6656	UDP-glucuronosyltransferase 3A1	UGT3A1	0.0006
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0006
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0006
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0006
634	Squalene monooxygenase	SQLE	0.0006
7196	Squalene monooxygenase	ERG1	0.0006
5626	Nucleoside diphosphate kinase B	NME2	0.0005
1721	Glycogen synthase kinase-3 beta	GSK3B	0.0005
1341	Histamine H3 receptor	HRH3	0.0005
3238	Multidrug resistance protein mexA	mexA	0.0005
3116	Bacterioferritin	bfr	0.0005
4906	Bacterioferritin	bfr	0.0005
4965	Bacterioferritin	bfr	0.0005
3173	Enolase	eno	0.0005
3709	Glycerol uptake facilitator protein	glpF	0.0005
3336	C4-dicarboxylate transport transcriptional regulatory protein dctD	dctD	0.0005
3393	TGF-beta receptor type-2	TGFBR2	0.0005
5489	Ribonucleoside-diphosphate reductase 1 subunit beta	nrdB	0.0005
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0005
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0005
2021	Thrombomodulin	THBD	0.0005
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0005
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0005
3221	Cytochrome c4	cc4	0.0005
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0005
6344	ATP synthase subunit gamma, mitochondrial	ATP5C1	0.0005
6343	ATP synthase subunit beta, mitochondrial	ATP5B	0.0005
6342	ATP synthase subunit alpha, mitochondrial	ATP5A1	0.0005
2852	DNA mismatch repair protein mutL	mutL	0.0005
2236	Casein kinase II subunit alpha	CSNK2A1	0.0005
5278	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1	PAPSS1	0.0005
3191	Histidinol dehydrogenase	hisD	0.0005
5294	Nucleoside diphosphate kinase A	NME1	0.0005
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0004
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0004
1992	Vitamin D-binding protein	GC	0.0004
76	Nitric-oxide synthase, brain	NOS1	0.0004
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0004
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0004
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0004
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0004
6259	(3R)-hydroxymyristoyl-acyl carrier protein dehydratase	fabZ	0.0004
4692	A/G-specific adenine glycosylase	mutY	0.0004
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0004
6042	Prostaglandin reductase 2	PTGR2	0.0004
6163	Copper-transporting ATPase 2	ATP7B	0.0004
6165	Copper-transporting ATPase 1	ATP7A	0.0004
2802	Endoglucanase G	celCCG	0.0004
340	Apoptotic protease-activating factor 1	APAF1	0.0004
251	Alcohol dehydrogenase 1A	ADH1A	0.0004
1792	Tissue-type plasminogen activator	PLAT	0.0004
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0004
820	Glycine receptor subunit alpha-2	GLRA2	0.0003
2101	Glutathione-requiring prostaglandin D synthase	HPGDS	0.0003
268	Adenosine A2b receptor	ADORA2B	0.0003
828	Phenylalanine-4-hydroxylase	PAH	0.0003
3109	Phenylalanine-4-hydroxylase	phhA	0.0003
825	Arsenical pump-driving ATPase	ASNA1	0.0003
3435	Arsenical pump-driving ATPase	arsA	0.0003
486	Serine/threonine-protein kinase ALS2CR7	CDK15	0.0003
2105	ATP-binding cassette sub-family G member 1	ABCG1	0.0003
377	Beta-adrenergic receptor kinase 1	ADRBK1	0.0003
510	Serine/threonine-protein kinase receptor R3	ACVRL1	0.0003
733	Activin receptor type 1B	ACVR1B	0.0003
225	NEDD8-activating enzyme E1 regulatory subunit	NAE1	0.0003
745	Anti-Muellerian hormone type-2 receptor	AMHR2	0.0003
483	A-Raf proto-oncogene serine/threonine-protein kinase	ARAF	0.0003
21	Beta-adrenergic receptor kinase 2	ADRBK2	0.0003
154	AFG3-like protein 2	AFG3L2	0.0003
395	ALK tyrosine kinase receptor	Not Available	0.0003
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.0003
849	Activated CDC42 kinase 1	TNK2	0.0003
1313	Lactoylglutathione lyase	GLO1	0.0003
704	Long-chain-fatty-acid--CoA ligase 1	ACSL1	0.0003
821	Acetyl-coenzyme A synthetase 2-like, mitochondrial	ACSS1	0.0003
386	Acetyl-coenzyme A synthetase, cytoplasmic	ACSS2	0.0003
297	Adenylate cyclase type 1	ADCY1	0.0003
289	Cytosolic purine 5'-nucleotidase	NT5C2	0.0003
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0003
1268	Neuropeptide S receptor	NPSR1	0.0003
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0003
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0003
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.0003
6073	Potassium channel subfamily K member 9	KCNK9	0.0003
6072	Potassium channel subfamily K member 3	KCNK3	0.0003
740	Argininosuccinate synthase	ASS1	0.0002
865	Argininosuccinate synthase	ASS1	0.0002
2680	Argininosuccinate synthase	argG	0.0002
3194	Argininosuccinate synthase	argG	0.0002
661	ADP/ATP translocase 1	SLC25A4	0.0002
6021	Adenosine kinase	ADK	0.0002
242	Asparagine synthetase [glutamine-hydrolyzing]	ASNS	0.0002
6135	Sodium channel subunit beta-4	SCN4B	0.0002
6134	Sodium channel subunit beta-3	SCN3B	0.0002
6132	Sodium channel subunit beta-1	SCN1B	0.0002
6127	Carbonic anhydrase-related protein	CA8	0.0002
6128	Carbonic anhydrase-related protein 10	CA10	0.0002
6133	Sodium channel subunit beta-2	SCN2B	0.0002
6129	Carbonic anhydrase-related protein 11	CA11	0.0002
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0002
6130	Carbonic anhydrase 13	CA13	0.0002
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0002
3007	Carbonic anhydrase 12	CA12	0.0002
4205	Carbonic anhydrase 9	CA9	0.0002
4936	Cytochrome c2 iso-2	Not Available	0.0001
4916	Cyanoglobin	glbN	0.0001
4994	Hemoglobin-like protein HbO	glbO	0.0001
4915	Cytochrome c-550	psbV	0.0001
4959	Cytochrome c-550	psbV	0.0001
5216	Cytochrome c-550	psbV	0.0001
4925	Cytochrome c-type protein SHP	shp	0.0001
4904	Cytochrome c family protein	GSU1996	0.0001
4943	Cytochrome c6	petJ	0.0001
4954	Soluble cytochrome b558	Not Available	0.0001
4934	Cytochrome c-551	nirM	0.0001
5218	Cytochrome c-551	nirM	0.0001
4905	Cytochrome c2	Not Available	0.0001
4939	Cytochrome c2	cycA	0.0001
4964	Cytochrome c2	cycA	0.0001
4979	Cytochrome c2	cycA	0.0001
6673	Cytochrome c2	cycA	0.0001
4910	Cytoglobin	CYGB	0.0001
4984	Neuroglobin	NGB	0.0001
4981	Iron-starvation protein PigA	pigA	0.0001
4909	CooA protein	cooA	0.0001
4998	Hemoglobin-like protein yjbI	yjbI	0.0001
4935	Cytochrome c-554	cycA1	0.0001
4947	Bacterial hemoglobin	vhb	0.0001
4975	Cytochrome c-556	RPA3973	0.0001
4942	Diheme cytochrome c napB	napB	0.0001
4931	Cytochrome P450 167A1	CYP167A1	0.0001
5000	HemO	hemO	0.0001
4972	P450cin	cinA	0.0001
4960	Putative cytochrome P450-family protein	SCO7417	0.0001
4971	Nonaheme cytochrome c	hmcA	0.0001
4989	Cytochrome c551 peroxidase	ccp	0.0001
5222	Cytochrome c551 peroxidase	ccpA	0.0001
4961	Hemophore HasA	hasA	0.0001
4976	Apocytochrome f	petA	0.0001
6407	Apocytochrome f	petA	0.0001
4907	Cytochrome c-L	moxG	0.0001
6865	Cytochrome c-L	moxG	0.0001
4993	Hydroxylamine oxidoreductase	hao1	0.0001
4764	Cytochrome P450 165C4	CYP165C4	0.0001
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0001
644	Heme oxygenase 2	HMOX2	0.0001
4982	Heme oxygenase 2	pbsA2	0.0001
4952	Catalase/peroxidase	katA	0.0001
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0001
4937	Cytochrome oxidase subunit II	rcoxA	0.0001
4903	Methyl-accepting chemotaxis protein	Tar4	0.0001
4999	Cytochrome P450 165B3	CYP165B3	0.0001
3093	Catalase HPII	katE	0.0001
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0001
4922	Cytochrome c, putative	SO_4144	0.0001
4920	Peroxidase/catalase	katG	0.0001
4990	PpcA	ppcA	0.0001
4948	Cytochrome c-553	Not Available	0.0001
4923	Cytochrome c3	DvMF_2499	0.0001
4945	Cytochrome c3	Not Available	0.0001
4949	Cytochrome c3	DVU_3171	0.0001
4968	Cytochrome c3	cytc3	0.0001
4997	Cytochrome c3	SO_2727	0.0001
5219	Cytochrome c3	cyd	0.0001
2119	Cytochrome b5	CYB5A	0.0001
4902	Nine-heme cytochrome c	Ddes_2038	0.0001
3189	High-molecular-weight cytochrome c	hmcA	0.0001
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0001
3375	Acidic cytochrome c3	Not Available	0.0001
4988	Sulfite oxidase, mitochondrial	SUOX	0.0001
2915	Sensor protein fixL	fixL	0.0001
4944	Sensor protein fixL	fixL	0.0001
4813	Heme oxygenase	hmuO	0.0001
5769	Heme oxygenase	Not Available	0.0001
3570	Cytochrome P450 152A1	cypC	0.0001
4385	Cytochrome c'	Not Available	0.0001
4967	Cytochrome c'	cycA	0.0001
5038	Cytochrome c'	Not Available	0.0001
5223	Cytochrome c'	cycP	0.0001
4037	Hypothetical protein	GPX1	0.0001
4297	Hypothetical protein	SP_1951	0.0001
4521	Hypothetical protein	BC_2969	0.0001
4540	Hypothetical protein	TM_1070	0.0001
4555	Hypothetical protein	MT1739	0.0001
4569	Hypothetical protein	mshD	0.0001
4578	Hypothetical protein	PA3270	0.0001
4747	Hypothetical protein	PA3967	0.0001
5177	Hypothetical protein	TM_0096	0.0001
5194	Hypothetical protein	PA1204	0.0001
5240	Hypothetical protein	Rv2991	0.0001
5370	Hypothetical protein	TM_1158	0.0001
5710	Hypothetical protein	Tb927.5.1360	0.0001
4289	Cytochrome P450	TT_P0059	0.0001
6262	Cytochrome P450	staP	0.0001
4992	Cytochrome c peroxidase	Not Available	0.0001
2230	Catalase	CAT	0.0001
3249	Catalase	katA	0.0001
3625	Catalase	katA	0.0001
4539	Catalase	katA	0.0001
4941	Catalase	katB	0.0001
3670	Soluble cytochrome b562 precursor	cybC	0.0001
3411	Cytochrome P450 121	cyp121	0.0001
3291	Cytochrome c-552	cycA	0.0001
4927	Cytochrome c-552	nrfA	0.0001
4938	Cytochrome c-552	cycA	0.0001
4953	Cytochrome c-552	nrfA	0.0001
5217	Cytochrome c-552	cycM	0.0001
2617	Nitric oxide synthase oxygenase	nos	0.0001
2701	Nitric oxide synthase oxygenase	nos	0.0001
3102	Flavohemoprotein	hmp	0.0001
4969	Flavohemoprotein	hmp	0.0001
4386	Hemoglobin-like protein HbN	glbN	0.0001
3127	Nitrite reductase	nirS	0.0001
3284	Nitrite reductase	nirS	0.0001
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0001
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0001
4608	Putative cytochrome P450	SCO1207	0.0001
4963	Putative cytochrome P450	SCO2884	0.0001
6254	Putative cytochrome P450	SCO6998	0.0001
358	Cystathionine beta-synthase	CBS	0
1507	Cytochrome c	CYCS	0
693	Hemoglobin subunit beta	HBB	0
6268	Hydroxyacid oxidase 1	HAO1	0
810	Heme oxygenase 1	HMOX1	0
3391	Heme oxygenase 1	pbsA1	0

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB00877 - Sirolimus

Targets

Enzymes

Transporters

Predictions