DT-Web: DB01012

Identification

Name

Cinacalcet

Accession Number

DB01012 (APRD00872)

Type

small molecule

Description

Cinacalcet (INN) is a drug that acts as a calcimimetic (i.e. it mimics the action of calcium on tissues) by allosteric activation of the calcium-sensing receptor that is expressed in various human organ tissues. It is sold by Amgen under the trade name Sensipar(R) in North America and Australia and as Mimpara(R) in Europe. Cinacalcet is used to treat hyperparathyroidism (elevated parathyroid hormone levels), a consequence of parathyroid tumors and chronic renal failure.

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Calcimimetics

Molecular Weight

357.412

Groups

approved

Monoisotopic Weight

357.170434324

Pharmacology

Indication

For the treatment of secondary hyperparathyroidism in patients with Chronic Kidney Disease who are on hemodialysis or peritoneal dialysis. Also for the treatment of hypercalcemia in patients with parathyroid carcinoma.

Mechanism of action

The calcium-sensing receptors on the surface of the chief cell of the parathyroid gland is the principal regulator of parathyroid hormone secretion (PTH). Cinacalcet directly lowers parathyroid hormone levels by increasing the sensitivity of the calcium sensing receptors to activation by extracellular calcium, resulting in the inhibition of PTH secretion. The reduction in PTH is associated with a concomitant decrease in serum calcium levels.

Absorption

Rapidly absorbed following oral administration.

Protein binding

Approximately 93 to 97% bound to plasma proteins.

Biotransformation

Metabolism is hepatic by multiple enzymes, primarily CYP3A4, CYP2D6, and CYP1A2. After administration of a 75 mg radiolabeled dose to healthy volunteers, cinacalcet was rapidly and extensively metabolized via: 1) oxidative N-dealkylation to hydrocinnamic acid and hydroxy-hydrocinnamic acid, which are further metabolized via ß-oxidation and glycine conjugation; the oxidative N-dealkylation process also generates metabolites that contain the naphthalene ring; and 2) oxidation of the naphthalene ring on the parent drug to form dihydrodiols, which are further conjugated with glucuronic acid.

Route of elimination

Cinacalcet is metabolized by multiple enzymes, primarily CYP3A4, CYP2D6 and CYP1A2. Renal excretion of metabolites was the primary route of elimination of radioactivity.

Toxicity

Doses titrated up to 300 mg once daily have been safely administered to patients on dialysis. Overdosage of cinacalcet may lead to hypocalcemia.

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug	Mechanism of interaction
Erythromycin	The macrolide, erythromycin, may increase the serum concentration and toxicity of cinacalcet.
Itraconazole	Itraconazole may increase the effect and toxicity of cinacalcet.
Ketoconazole	Ketoconazole may increase the effect and toxicity of cinacalcet.
Tamoxifen	Cinacalcet may decrease the therapeutic effect of Tamoxifen by decreasing the production of active metabolites. Concomitant therapy should be avoided.
Tamsulosin	Cinacalcet, a CYP2D6 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP2D6 substrate. Monitor for changes in therapeutic/adverse effects of Tamsulosin if Cinacalcet is initiated, discontinued, or dose changed.
Telithromycin	Telithromycin may reduce clearance of Cinacalcet. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Cinacalcet if Telithromycin is initiated, discontinued or dose changed.
Tolterodine	Cinacalcet may decrease the metabolism and clearance of Tolterodine. Monitor for adverse/toxic effects of Tolterodine.
Tramadol	Cinacalcet may decrease the effect of Tramadol by decreasing active metabolite production.
Trimipramine	The strong CYP2D6 inhibitor, Cinacalcet, may decrease the metabolism and clearance of Trimipramine, a CYP2D6 substrate. Consider alternate therapy or monitor for changes in therapeutic and adverse effects of Trimipramine if Cinacalcet is initiated, discontinued or dose changed.
Venlafaxine	Cinacalcet, a CYP2D6 inhibitor, may decrease the metabolism and clearance of Venlafaxine, a CYP2D6 substrate. Monitor for changes in therapeutic/adverse effects of Venlafaxine if Cinacalcet is initiated, discontinued, or dose changed.
Voriconazole	Voriconazole, a strong CYP3A4 inhibitor, may increase the serum concentration of cinacalcet by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of cinacalcet if voriconazole is initiated, discontinued or dose changed.
Zuclopenthixol	Cinacalcet, a strong CYP2D6 inhibitor, may increase the serum concentration of zuclopenthixol by decreasing its metabolism. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of zuclopenthixol if cinacalcet is initiated, discontinued or dose changed.

Food Interactions

Food markedly increases product bioavailability.
Peak levels and area under curve (drug exposure) are increased (82% and 68% respectively) when product is taken with a lipid-rich meal.
Take with food or soon after a meal.

Extracellular calcium-sensing receptor
Name	Extracellular calcium-sensing receptor
Gene Name	CASR
Pharmacological action	yes
Actions	agonist
References	de Francisco AL: Cinacalcet HCl: a novel therapeutic for hyperparathyroidism. Expert Opin Pharmacother. 2005 Mar;6(3):441-52. - Pubmed Rothe HM, Shapiro WB, Sun WY, Chou SY: Calcium-sensing receptor gene polymorphism Arg990Gly and its possible effect on response to cinacalcet HCl. Pharmacogenet Genomics. 2005 Jan;15(1):29-34. - Pubmed Tasic V: Management of renal osteodystrophy in children. Turk J Pediatr. 2005;47 Suppl:13-8. - Pubmed Moe SM, Cunningham J, Bommer J, Adler S, Rosansky SJ, Urena-Torres P, Albizem MB, Guo MD, Zani VJ, Goodman WG, Sprague SM: Long-term treatment of secondary hyperparathyroidism with the calcimimetic cinacalcet HCl. Nephrol Dial Transplant. 2005 Oct;20(10):2186-93. Epub 2005 Jul 19. - Pubmed Cunningham J: Management of secondary hyperparathyroidism. Ther Apher Dial. 2005 Aug;9 Suppl 1:S35-40. - Pubmed Eriguchi R, Umakoshi J, Tominaga Y, Sato Y: Successful treatment of inoperable recurrent secondary hyperparathyroidism with cinacalcet HCl. NDT Plus. 2008 Aug;1(4):218-220. Epub 2008 May 25. - Pubmed Belozeroff V, Goodman WG, Ren L, Kalantar-Zadeh K: Cinacalcet lowers serum alkaline phosphatase in maintenance hemodialysis patients. Clin J Am Soc Nephrol. 2009 Mar;4(3):673-9. Epub 2009 Mar 4. - Pubmed Meola M, Petrucci I, Barsotti G: Long-term treatment with cinacalcet and conventional therapy reduces parathyroid hyperplasia in severe secondary hyperparathyroidism. Nephrol Dial Transplant. 2009 Mar;24(3):982-9. Epub 2009 Jan 30. - Pubmed Drueke TB, Ritz E: Treatment of secondary hyperparathyroidism in CKD patients with cinacalcet and/or vitamin D derivatives. Clin J Am Soc Nephrol. 2009 Jan;4(1):234-41. Epub 2008 Dec 3. - Pubmed Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score	0.508

Cytochrome P450 3A4
Name	Cytochrome P450 3A4
Gene Name	CYP3A4
Actions	substrate
References	Padhi D, Harris R: Clinical pharmacokinetic and pharmacodynamic profile of cinacalcet hydrochloride. Clin Pharmacokinet. 2009;48(5):303-11. - Pubmed Dong BJ: Cinacalcet: An oral calcimimetic agent for the management of hyperparathyroidism. Clin Ther. 2005 Nov;27(11):1725-51. - Pubmed
DTHybrid score	0.4616
Cytochrome P450 2D6
Name	Cytochrome P450 2D6
Gene Name	CYP2D6
Actions	inhibitor
References	Padhi D, Harris R: Clinical pharmacokinetic and pharmacodynamic profile of cinacalcet hydrochloride. Clin Pharmacokinet. 2009;48(5):303-11. - Pubmed Dong BJ: Cinacalcet: An oral calcimimetic agent for the management of hyperparathyroidism. Clin Ther. 2005 Nov;27(11):1725-51. - Pubmed Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
DTHybrid score	0.4088
Cytochrome P450 1A2
Name	Cytochrome P450 1A2
Gene Name	CYP1A2
Actions	substrate
References	Padhi D, Harris R: Clinical pharmacokinetic and pharmacodynamic profile of cinacalcet hydrochloride. Clin Pharmacokinet. 2009;48(5):303-11. - Pubmed Dong BJ: Cinacalcet: An oral calcimimetic agent for the management of hyperparathyroidism. Clin Ther. 2005 Nov;27(11):1725-51. - Pubmed
DTHybrid score	0.3821

Id	Partner name	Gene Name	Score
4757	Cytochrome P450 2C9	CYP2C9	0.1388
6016	Cytochrome P450 2C19	CYP2C19	0.1285
1588	Multidrug resistance protein 1	ABCB1	0.1161
4118	Cytochrome P450 3A5	CYP3A5	0.1022
4924	Cytochrome P450 2C8	CYP2C8	0.0918
6030	Cytochrome P450 2B6	CYP2B6	0.0815
6013	Cytochrome P450 2E1	CYP2E1	0.0783
6107	Cytochrome P450 3A7	CYP3A7	0.0742
6024	Cytochrome P450 1A1	CYP1A1	0.0718
492	Histamine H1 receptor	HRH1	0.0493
5718	Cytochrome P450 2A6	CYP2A6	0.0477
824	Sodium-dependent serotonin transporter	SLC6A4	0.0399
587	Serum albumin	ALB	0.0376
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.0368
831	D(2) dopamine receptor	DRD2	0.0364
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0363
556	Alpha-1A adrenergic receptor	ADRA1A	0.0351
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.0338
1181	Alpha-1-acid glycoprotein 1	ORM1	0.0317
20	Prostaglandin G/H synthase 1	PTGS1	0.0311
318	Alpha-2A adrenergic receptor	ADRA2A	0.0298
766	Beta-2 adrenergic receptor	ADRB2	0.0274
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0267
193	Beta-1 adrenergic receptor	ADRB1	0.0265
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0264
36	Insulin receptor	INSR	0.0258
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0257
6145	Solute carrier family 22 member 1	SLC22A1	0.0253
23	D(1A) dopamine receptor	DRD1	0.0247
3811	Cytochrome P450 19A1	CYP19A1	0.0241
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0241
713	Sodium-dependent dopamine transporter	SLC6A3	0.0238
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.0222
6106	Cytochrome P450 2C18	CYP2C18	0.0214
632	Alpha-1B adrenergic receptor	ADRA1B	0.0213
847	Mu-type opioid receptor	OPRM1	0.0211
118	Organic cation/carnitine transporter 2	SLC22A5	0.0209
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0206
862	Multidrug resistance-associated protein 1	ABCC1	0.0203
871	Glucocorticoid receptor	NR3C1	0.0203
1898	Cytochrome P450 1B1	CYP1B1	0.02
6144	Solute carrier family 22 member 2	SLC22A2	0.0197
1729	Solute carrier family 22 member 6	SLC22A6	0.0196
3941	Amine oxidase [flavin-containing] A	MAOA	0.019
885	5-hydroxytryptamine 1B receptor	HTR1B	0.019
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.0189
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0188
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0186
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0176
638	D(3) dopamine receptor	DRD3	0.0171
290	Prostaglandin G/H synthase 2	PTGS2	0.017
467	Delta-type opioid receptor	OPRD1	0.0167
629	Alpha-2B adrenergic receptor	ADRA2B	0.0166
817	DNA topoisomerase 2-alpha	TOP2A	0.0166
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.0165
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0161
731	HIV-1 protease	HIV-1 protease	0.016
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0159
136	Estrogen receptor	ESR1	0.0156
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0154
696	Kappa-type opioid receptor	OPRK1	0.0151
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0148
477	DNA topoisomerase 4 subunit A	parC	0.0146
886	DNA topoisomerase 4 subunit A	parC	0.0146
6226	DNA topoisomerase 4 subunit A	parC	0.0146
378	Alpha-2C adrenergic receptor	ADRA2C	0.0145
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0144
404	DNA gyrase subunit A	gyrA	0.0144
6224	DNA gyrase subunit A	gyrA	0.0144
789	Alpha-1D adrenergic receptor	ADRA1D	0.0142
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0141
3923	Cholinesterase	BCHE	0.0137
432	D(4) dopamine receptor	DRD4	0.0132
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0132
3939	Amine oxidase [flavin-containing] B	MAOB	0.0131
465	Calmodulin	CALM1	0.013
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0127
833	Organic cation/carnitine transporter 1	SLC22A4	0.0125
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0122
776	Bile salt export pump	ABCB11	0.0119
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0109
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0109
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0109
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0107
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0104
474	Acetylcholinesterase	ACHE	0.0102
6147	Solute carrier family 22 member 3	SLC22A3	0.0101
260	Cytochrome P450 51	ERG11	0.01
761	Cytochrome P450 51	ERG11	0.01
3163	Cytochrome P450 51	cyp51	0.01
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.01
958	Insulin-like growth factor 1 receptor	IGF1R	0.0097
163	D(1B) dopamine receptor	DRD5	0.0096
6142	Solute carrier family 22 member 8	SLC22A8	0.0096
232	Corticosteroid-binding globulin	SERPINA6	0.0093
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0091
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.009
6143	Solute carrier family 22 member 7	SLC22A7	0.009
818	50S ribosomal protein L10	rplJ	0.0089
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0088
16	Adenosine A1 receptor	ADORA1	0.0087
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0086
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0086
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0086
6031	Cytochrome P450 3A43	CYP3A43	0.0086
2164	Multidrug resistance-associated protein 4	ABCC4	0.0085
6220	Aryl hydrocarbon receptor	AHR	0.0083
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0083
1178	Adenosine A2a receptor	ADORA2A	0.0082
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0082
468	Cytochrome P450 4A11	CYP4A11	0.0081
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0081
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0079
173	Toll-like receptor 7	TLR7	0.0079
6182	Cytochrome P450 2J2	CYP2J2	0.0078
716	5-hydroxytryptamine 7 receptor	HTR7	0.0078
777	Tumor necrosis factor	TNF	0.0076
614	Progesterone receptor	PGR	0.0076
3947	Xanthine dehydrogenase/oxidase	XDH	0.0075
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0073
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0073
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0072
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0071
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0069
94	5-hydroxytryptamine 4 receptor	HTR4	0.0067
124	Histamine H2 receptor	HRH2	0.0066
6014	Cytochrome P450 2A13	CYP2A13	0.0065
571	Melatonin receptor type 1A	MTNR1A	0.0064
362	Melatonin receptor type 1B	MTNR1B	0.0064
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0063
504	Mast/stem cell growth factor receptor	KIT	0.0062
380	Cytochrome P450 17A1	CYP17A1	0.0061
122	P2Y purinoceptor 12	P2RY12	0.0061
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0061
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0061
952	Dipeptidyl peptidase 4	DPP4	0.0061
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0061
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0061
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0061
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.006
6148	Multidrug resistance-associated protein 7	ABCC10	0.006
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.006
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0059
131	Synaptic vesicular amine transporter	SLC18A2	0.0059
161	Tubulin beta chain	TUBB	0.0058
312	Tubulin beta chain	TUB2	0.0058
1656	CYP2B protein	CYP2B	0.0057
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0056
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0056
146	Androgen receptor	AR	0.0056
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0055
4122	Histone deacetylase 2	HDAC2	0.0055
6506	Stathmin-4	STMN4	0.0055
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0054
844	Epidermal growth factor receptor	EGFR	0.0054
6020	Aldehyde oxidase	AOX1	0.0053
5998	Toll-like receptor 8	TLR8	0.0053
407	Vascular endothelial growth factor receptor 2	KDR	0.0052
712	Tubulin alpha chain	TUB1	0.0052
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0052
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0052
2112	Toll-like receptor 9	TLR9	0.0051
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0051
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0051
4199	Sphingosine 1-phosphate receptor Edg-8	S1PR5	0.005
613	Atrial natriuretic peptide receptor A	NPR1	0.005
4604	Liver carboxylesterase 1	CES1	0.005
373	Transthyretin	TTR	0.0049
26	Vascular endothelial growth factor receptor 3	FLT4	0.0049
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0049
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0049
1517	Beta-3 adrenergic receptor	ADRB3	0.0048
284	DNA-directed RNA polymerase beta chain	rpoB	0.0048
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0048
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0047
32	Vascular endothelial growth factor receptor 1	FLT1	0.0047
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0047
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0047
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0046
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0046
1757	Myeloperoxidase	MPO	0.0046
4228	Keratin, type II cytoskeletal 7	KRT7	0.0046
814	Ryanodine receptor 1	RYR1	0.0046
869	Estrogen receptor beta	ESR2	0.0046
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0046
4237	50S ribosomal protein L22	rplV	0.0046
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0045
70	Type-1 angiotensin II receptor	AGTR1	0.0045
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0045
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0044
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0044
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0044
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.0044
6102	Arylamine N-acetyltransferase 2	NAT2	0.0044
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.0043
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0043
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0043
1629	Transcription factor AP-1	JUN	0.0042
811	Translocator protein	TSPO	0.0042
714	Glutathione reductase, mitochondrial	GSR	0.0042
1010	Cytochrome P450 51A1	CYP51A1	0.0042
1024	Solute carrier family 22 member 11	SLC22A11	0.0042
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0042
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0042
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0042
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0042
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0042
756	Sex hormone-binding globulin	SHBG	0.0041
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0041
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0041
2449	Tubulin alpha-3 chain	TUBA1A	0.0041
6043	Putative G-protein coupled receptor 44	GPR44	0.0041
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0041
3997	Cytochrome P450 24A1, mitochondrial	CYP24A1	0.0041
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.004
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.004
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.004
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.004
273	Apoptosis regulator Bcl-2	BCL2	0.004
856	Vitamin D3 receptor	VDR	0.004
29	Tubulin beta-1 chain	TUBB1	0.004
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.004
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.004
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.004
365	Dihydrofolate reductase	DHFR	0.004
2381	Dihydrofolate reductase	DFR1	0.004
2833	Dihydrofolate reductase	Not Available	0.004
2931	Dihydrofolate reductase	folA	0.004
3544	Dihydrofolate reductase	folA	0.004
3682	Dihydrofolate reductase	folA	0.004
6642	Dihydrofolate reductase	folA	0.004
6756	Dihydrofolate reductase	dfrA	0.004
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.004
295	Carbonic anhydrase 1	CA1	0.0039
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.0039
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0039
1129	C-C chemokine receptor type 5	CCR5	0.0039
6137	Multidrug resistance-associated protein 6	ABCC6	0.0038
592	Carbonic anhydrase 4	CA4	0.0038
605	Fumarate reductase flavoprotein subunit	frdA	0.0038
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0038
3673	Fumarate reductase flavoprotein subunit	fccA	0.0038
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0038
6549	Fumarate reductase flavoprotein subunit	frdA	0.0038
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0038
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0038
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0038
4120	NADPH--cytochrome P450 reductase	POR	0.0037
891	Dihydropteroate synthase	folP	0.0037
5359	Dihydropteroate synthase	folP	0.0037
7175	Dihydropteroate synthase	sulI	0.0037
705	Glutamate receptor 1	GRIA1	0.0037
1050	Bile salt sulfotransferase	SULT2A1	0.0036
6044	Serum paraoxonase/lactonase 3	PON3	0.0036
68	Cannabinoid receptor 1	CNR1	0.0036
543	Penicillin-binding protein 1B	mrcB	0.0035
6186	Penicillin-binding protein 1B	ponB	0.0035
6822	Penicillin-binding protein 1b	pbp1b	0.0035
6844	Penicillin-binding protein 1b	pbp1b	0.0035
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0035
185	Vasopressin V1a receptor	AVPR1A	0.0035
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0035
117	Sterol O-acyltransferase 1	SOAT1	0.0035
159	Penicillin-binding protein 2B	penA	0.0035
6121	Penicillin-binding protein 2B	penA	0.0035
939	50S ribosomal protein L3	rplC	0.0035
6432	Transporter	snf	0.0035
322	Vasopressin V2 receptor	AVPR2	0.0034
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0034
2499	Tubulin beta-2C chain	TUBB2C	0.0034
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0034
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.0033
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0033
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0033
737	Mineralocorticoid receptor	NR3C2	0.0033
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0032
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0032
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0032
275	Arachidonate 5-lipoxygenase	ALOX5	0.0032
140	30S ribosomal protein S9	rpsI	0.0031
6719	30S ribosomal protein S9	rpsI	0.0031
6725	30S ribosomal protein S9	rpsI	0.0031
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0031
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0031
1636	Trace amine-associated receptor 1	TAAR1	0.0031
482	Glycine receptor subunit alpha-1	GLRA1	0.0031
6136	Multidrug resistance-associated protein 5	ABCC5	0.0031
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0031
427	Substance-P receptor	TACR1	0.0031
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0031
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0031
2578	Tubulin beta-3 chain	TUBB3	0.003
904	Glutathione S-transferase P	GSTP1	0.003
2285	Streptogramin A acetyltransferase	vatD	0.003
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.003
4203	Histamine N-methyltransferase	HNMT	0.003
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.003
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.003
4238	50S ribosomal protein L4	rplD	0.0029
5578	50S ribosomal protein L4	rplD	0.0029
6173	50S ribosomal protein L4	rplD	0.0029
6219	50S ribosomal protein L4	rplD	0.0029
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0029
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0029
4311	tRNA	TRDMT1	0.0029
4325	tRNA	trmD	0.0029
4328	tRNA	trmD	0.0029
357	Carbonic anhydrase 2	CA2	0.0029
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0029
3957	Adenosine deaminase	ADA	0.0029
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0029
512	DNA-directed RNA polymerase alpha chain	rpoA	0.0029
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.0029
992	Protein tyrosine kinase 2 beta	PTK2B	0.0028
518	Peroxidase/catalase T	katG	0.0028
3932	Glutathione S-transferase A2	GSTA2	0.0028
723	Cytosolic phospholipase A2	PLA2G4A	0.0027
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0027
4173	Tyrosine-protein kinase JAK2	JAK2	0.0027
3856	Fibroblast growth factor receptor 3	FGFR3	0.0027
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0027
3849	Insulin-like growth factor-binding protein 7	IGFBP7	0.0027
2009	Protein NOV homolog	NOV	0.0027
3847	Neuroendocrine convertase 2	PCSK2	0.0027
1949	Carboxypeptidase E	CPE	0.0027
3850	Synaptotagmin-like protein 4	SYTL4	0.0027
3848	Neuroendocrine convertase 1	PCSK1	0.0027
3846	Retinoblastoma-associated protein	RB1	0.0027
921	Glutamate receptor 2	GRIA2	0.0027
6141	Sodium/bile acid cotransporter	SLC10A1	0.0026
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0026
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0026
563	Thyroid peroxidase	TPO	0.0026
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0026
790	DNA polymerase subunit alpha B	POLA2	0.0026
1648	Elastin	ELN	0.0026
49	Endothelin B receptor	EDNRB	0.0026
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0025
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0025
5880	Thrombopoietin receptor	MPL	0.0025
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0025
390	Adenosine A3 receptor	ADORA3	0.0025
768	FK506-binding protein 1A	FKBP1A	0.0025
634	Squalene monooxygenase	SQLE	0.0025
7196	Squalene monooxygenase	ERG1	0.0025
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0024
578	Endothelin-1 receptor	EDNRA	0.0024
544	Potassium voltage-gated channel subfamily E member 1	KCNE1	0.0024
1483	Membrane copper amine oxidase	AOC3	0.0024
6039	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	PDE11A	0.0024
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0024
738	Monocarboxylate transporter 1	SLC16A1	0.0024
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0024
6070	Nischarin	NISCH	0.0024
233	Potassium channel subfamily K member 2	KCNK2	0.0024
5852	Type-2 angiotensin II receptor	AGTR2	0.0024
174	Sigma 1-type opioid receptor	SIGMAR1	0.0024
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.0023
642	3-oxo-5-alpha-steroid 4-dehydrogenase 2	SRD5A2	0.0023
1192	Sulfotransferase 1A1	SULT1A1	0.0023
3086	Plasmepsin-2	Not Available	0.0023
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0023
550	Amiloride-sensitive sodium channel subunit delta	SCNN1D	0.0023
27	Amiloride-sensitive sodium channel subunit beta	SCNN1B	0.0023
552	Amiloride-sensitive sodium channel subunit gamma	SCNN1G	0.0023
213	Amiloride-sensitive sodium channel subunit alpha	SCNN1A	0.0023
1830	5'-nucleotidase	NT5E	0.0023
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0023
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.0023
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.0023
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0023
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0022
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0022
208	DNA-directed RNA polymerase beta' chain	rpoC	0.0022
5774	DNA-directed RNA polymerase beta' chain	rpoC	0.0022
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0022
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0022
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0022
6146	High affinity copper uptake protein 1	SLC31A1	0.0022
581	Cytochrome P450 2R1	CYP2R1	0.0022
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0022
239	Coagulation factor X	F10	0.0022
3404	Exotoxin A	eta	0.0022
780	Retinoic acid receptor RXR-gamma	RXRG	0.0022
2155	Insulin-degrading enzyme	IDE	0.0022
165	FL cytokine receptor	FLT3	0.0021
298	Renin	REN	0.0021
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.0021
33	Cystine/glutamate transporter	SLC7A11	0.0021
2091	Endoplasmin	HSP90B1	0.0021
1618	High affinity nerve growth factor receptor	NTRK1	0.0021
1244	Low-density lipoprotein receptor-related protein 2	LRP2	0.0021
2539	Tubulin alpha-1 chain	TUBA4A	0.0021
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0021
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0021
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0021
63	Malate dehydrogenase	mdh	0.0021
2329	Malate dehydrogenase	mdh	0.0021
3445	Malate dehydrogenase	mdh	0.0021
4420	Malate dehydrogenase	mdh	0.0021
4438	Malate dehydrogenase	mdh	0.0021
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0021
164	Histamine H4 receptor	HRH4	0.002
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.002
6126	Carbonic anhydrase 7	CA7	0.002
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.002
1820	Beta-nerve growth factor	NGF	0.002
88	Retinoic acid receptor RXR-beta	RXRB	0.002
633	Penicillin-binding proteins 1A/1B	pbpA	0.0019
183	Vascular endothelial growth factor A	VEGFA	0.0019
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0019
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0019
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0019
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0019
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0019
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0019
823	Fibroblast growth factor receptor 2	FGFR2	0.0019
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0019
473	L-lactate dehydrogenase A chain	LDHA	0.0019
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0019
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0019
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0019
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0019
153	Dopamine beta-hydroxylase	DBH	0.0018
893	[Citrate [pro-3S]-lyase] ligase	citC	0.0018
845	Pyruvate dehydrogenase [cytochrome]	poxB	0.0018
976	Platelet glycoprotein IX	GP9	0.0018
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0018
6766	O-GlcNAcase BT_4395	BT_4395	0.0018
1968	ATP-sensitive inward rectifier potassium channel 12	KCNJ12	0.0018
327	Glutathione reductase	gor	0.0018
5110	Glutathione reductase	GR2	0.0018
4103	Proteasome subunit beta type 2	PSMB2	0.0018
4102	Proteasome subunit beta type 5	PSMB5	0.0018
4101	Proteasome subunit beta type 1	PSMB1	0.0018
1374	Natriuretic peptides B	NPPB	0.0018
1827	Gap junction alpha-1 protein	GJA1	0.0018
1908	Vascular cell adhesion protein 1	VCAM1	0.0018
683	Potassium transporter	GK0582	0.0018
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.0018
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0018
459	Retinoic acid receptor RXR-alpha	RXRA	0.0018
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0017
621	Periplasmic [Fe] hydrogenase 1	Not Available	0.0017
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0017
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0017
2290	ADP-ribosyl cyclase 2	BST1	0.0017
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.0017
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0017
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0017
4192	DNA topoisomerase 2-beta	TOP2B	0.0017
144	Hemoglobin subunit alpha	HBA1	0.0016
4209	ATP-sensitive inward rectifier potassium channel 8	KCNJ8	0.0016
4773	Deoxycytidine kinase	DCK	0.0016
1243	Cathepsin D	CTSD	0.0016
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0016
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0016
1852	Microtubule-associated protein 2	MAP2	0.0016
3810	Catechol O-methyltransferase	COMT	0.0016
3233	Bile acid receptor	NR1H4	0.0015
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0015
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0015
5787	Angiopoietin-1 receptor	TEK	0.0015
3126	Poly [ADP-ribose] polymerase 1	PARP1	0.0015
6138	Multidrug resistance protein 3	ABCB4	0.0015
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0015
982	Cocaine- and amphetamine-regulated transcript protein	CARTPT	0.0015
268	Adenosine A2b receptor	ADORA2B	0.0015
3937	Fatty-acid amide hydrolase	FAAH	0.0015
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0015
1714	Mitogen-activated protein kinase 3	MAPK3	0.0015
828	Phenylalanine-4-hydroxylase	PAH	0.0015
3109	Phenylalanine-4-hydroxylase	phhA	0.0015
3844	HLA class II histocompatibility antigen, DQ(6) alpha chain	HLA-DQA2	0.0015
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.0015
6824	Tyrosine-protein kinase Lyn	LYN	0.0014
1541	Metalloproteinase	mmp20	0.0014
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0014
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0014
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0014
6167	Organic solute transporter subunit beta	OSTB	0.0014
6166	Organic solute transporter subunit alpha	OSTA	0.0014
1341	Histamine H3 receptor	HRH3	0.0014
1262	Corticotropin-lipotropin	POMC	0.0014
7	Nitric oxide synthase, inducible	NOS2	0.0014
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0014
6859	Protein S100-A4	S100A4	0.0014
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0013
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0013
54	Prothrombin	F2	0.0013
1864	RET proto-oncogene	RET	0.0013
1353	DNA topoisomerase 1	TOP1	0.0013
3552	DNA topoisomerase 1	topA	0.0013
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0013
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0013
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0013
244	Angiotensin-converting enzyme	ACE	0.0013
2236	Casein kinase II subunit alpha	CSNK2A1	0.0013
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0013
6211	Tubulin epsilon chain	TUBE1	0.0013
6212	Tubulin gamma-1 chain	TUBG1	0.0013
6210	Tubulin delta chain	TUBD1	0.0013
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0013
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0013
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0013
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0013
908	Glutathione S-transferase theta-1	GSTT1	0.0013
1275	Estrogen sulfotransferase	SULT1E1	0.0013
860	Nicotinamide N-methyltransferase	NNMT	0.0013
5626	Nucleoside diphosphate kinase B	NME2	0.0013
699	Nicotinic acid receptor 1	GPR109A	0.0013
928	Nicotinic acid receptor 2	GPR109B	0.0013
583	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	QPRT	0.0013
2442	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0013
2459	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0013
424	Dihydroorotate dehydrogenase, mitochondrial	DHODH	0.0013
6116	Gastric triacylglycerol lipase	LIPF	0.0012
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0012
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0012
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0012
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0012
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0012
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0012
760	Fibroblast growth factor 1	FGF1	0.0012
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0012
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0012
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0012
3823	Cytokine receptor common gamma chain	IL2RG	0.0012
85	Growth hormone receptor	GHR	0.0012
2107	Microtubule-associated protein 1A	MAP1A	0.0012
338	DNA polymerase	UL30	0.0012
379	DNA polymerase	UL54	0.0012
697	DNA polymerase	ORF28	0.0012
2482	DNA polymerase	43	0.0012
4104	DNA polymerase	BALF5	0.0012
896	Glutathione S-transferase Mu 1	GSTM1	0.0012
5934	Cytochrome P450 26A1	CYP26A1	0.0012
1295	Fatty acid synthase	FASN	0.0012
936	Ephrin type-A receptor 2	EPHA2	0.0012
751	Potassium channel subfamily K member 6	KCNK6	0.0012
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0012
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0011
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0011
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0011
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0011
1992	Vitamin D-binding protein	GC	0.0011
754	Pancreatic triacylglycerol lipase	PNLIP	0.0011
319	Opioid receptor, sigma 1	OPRS1	0.0011
24	Thymidylate synthase	TMP1	0.0011
359	Thymidylate synthase	TYMS	0.0011
2626	Thymidylate synthase	thyA	0.0011
2729	Thymidylate synthase	thyA	0.0011
5352	Thymidylate synthase	THYA	0.0011
707	72 kDa type IV collagenase	MMP2	0.0011
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0011
172	Potassium channel subfamily K member 1	KCNK1	0.0011
2178	Metabotropic glutamate receptor 5	GRM5	0.0011
724	Interleukin-2 receptor alpha chain	IL2RA	0.0011
717	Interleukin-2 receptor subunit beta	IL2RB	0.0011
162	Retinoic acid receptor gamma-1	RARG	0.001
2300	Lysozyme	E	0.001
3633	Lysozyme	R	0.001
5597	Lysozyme	17	0.001
1630	Integrin beta-2	ITGB2	0.001
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.001
251	Alcohol dehydrogenase 1A	ADH1A	0.001
1810	Protein S100-A1	S100A1	0.001
6097	Protein S100-A2	S100A2	0.001
4116	Dihydropteroate synthetase	Not Available	0.001
469	Annexin A1	ANXA1	0.001
1144	Hepatocyte growth factor receptor	MET	0.001
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.001
493	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	CYP27B1	0.001
5294	Nucleoside diphosphate kinase A	NME1	0.001
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.001
2216	Fibroblast growth factor receptor 4	FGFR4	0.001
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.001
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.001
5300	Antigen peptide transporter 1	TAP1	0.001
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.001
4041	Microsomal glutathione S-transferase 2	MGST2	0.001
291	Nitric-oxide synthase, endothelial	NOS3	0.001
820	Glycine receptor subunit alpha-2	GLRA2	0.001
2268	Cholesterol oxidase	choB	0.0009
2822	Cholesterol oxidase	choA	0.0009
484	Tyrosine-protein kinase ABL2	ABL2	0.0009
444	Alcohol dehydrogenase 1B	ADH1B	0.0009
229	Retinoic acid receptor beta	RARB	0.0009
1064	DNA (cytosine-5)-methyltransferase 1	DNMT1	0.0009
6105	3-oxo-5-beta-steroid 4-dehydrogenase	AKR1D1	0.0009
6085	Fatty acid-binding protein, intestinal	FABP2	0.0009
65	Matrix metalloproteinase-9	Not Available	0.0009
730	Retinoic acid receptor alpha	RARA	0.0009
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0009
1048	Protein S100-A13	S100A13	0.0009
2226	Protein S100-A12	S100A12	0.0009
6048	Troponin C, skeletal muscle	TNNC2	0.0009
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0009
1770	Phospholipase C	PLCL1	0.0009
2841	Phospholipase C	plc	0.0009
6149	Solute carrier family 22 member 10	SLC22A10	0.0009
84	Nuclear receptor 0B1	NR0B1	0.0009
6131	Carbonic anhydrase 14	CA14	0.0009
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0009
2283	Steroid Delta-isomerase	ksi	0.0009
2920	Steroid Delta-isomerase	ksi	0.0009
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0009
2132	Protein S100-B	S100B	0.0009
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0008
22	30S ribosomal protein S4	rpsD	0.0008
6714	30S ribosomal protein S4	rpsD	0.0008
6122	Carbonic anhydrase 3	CA3	0.0008
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0008
2325	Sulfotransferase family cytosolic 2B member 1	SULT2B1	0.0008
3830	Calreticulin	CALR	0.0008
1867	Major prion protein	PRNP	0.0008
517	Alcohol dehydrogenase 1C	ADH1C	0.0008
572	Integrin alpha-L	ITGAL	0.0008
2232	Interleukin-5	IL5	0.0008
1593	Mucin-2	MUC2	0.0008
4031	Glutathione S-transferase A1	GSTA1	0.0008
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0008
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0008
6034	Hydroxyindole O-methyltransferase	ASMT	0.0008
500	Monocarboxylate transporter 4	SLC16A3	0.0008
6035	Nuclear receptor ROR-beta	RORB	0.0008
6036	Eosinophil peroxidase	EPX	0.0008
1649	Small inducible cytokine A2	CCL2	0.0008
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0008
1025	Aquaporin-1	AQP1	0.0008
1039	Histone deacetylase 9	HDAC9	0.0008
400	Coagulation factor IX	F9	0.0008
5461	Coagulation factor IX	F9	0.0008
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.0007
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0007
866	Large neutral amino acids transporter small subunit 2	SLC7A8	0.0007
4226	Uridine phosphorylase 2	UPP2	0.0007
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0007
461	Glycine receptor subunit alpha-3	GLRA3	0.0007
130	Prostacyclin synthase	PTGIS	0.0007
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0007
6103	Arylamine N-acetyltransferase 1	NAT1	0.0007
822	Aldose reductase	AKR1B1	0.0007
1768	Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit	GNG2	0.0007
1268	Neuropeptide S receptor	NPSR1	0.0007
1571	G protein-activated inward rectifier potassium channel 1	KCNJ3	0.0007
1581	G protein-activated inward rectifier potassium channel 2	KCNJ6	0.0007
4081	Vitamin K epoxide reductase complex subunit 1-like protein 1	VKORC1L1	0.0007
604	Vitamin K-dependent protein Z	PROZ	0.0007
6228	Nuclear receptor coactivator 1	NCOA1	0.0007
6207	30S ribosomal protein S14	rpsN	0.0007
6209	30S ribosomal protein S19	rpsS	0.0007
6712	30S ribosomal protein S19	rpsS	0.0007
6726	30S ribosomal protein S19	rpsS	0.0007
6241	Nuclear receptor coactivator 2	NCOA2	0.0007
645	Penicillin-binding protein 1A	mrcA	0.0007
5805	Penicillin-binding protein 1A	ponA	0.0007
6185	Penicillin-binding protein 1A	mrcA	0.0007
6799	Penicillin-binding protein 1A	pbpA	0.0007
5924	Microtubule-associated protein 4	MAP4	0.0007
5923	Microtubule-associated protein tau	MAPT	0.0007
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.0007
2298	Cytochrome P450-cam	camC	0.0007
226	Gonadotropin-releasing hormone receptor	GNRHR	0.0007
765	Indoleamine 2,3-dioxygenase	IDO1	0.0007
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0007
4225	Uridine phosphorylase 1	UPP1	0.0007
125	DNA polymerase beta	POLB	0.0007
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0007
1123	Eosinophil cationic protein	RNASE3	0.0007
2599	Tyrosine-protein kinase HCK	HCK	0.0007
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0007
6073	Potassium channel subfamily K member 9	KCNK9	0.0006
6072	Potassium channel subfamily K member 3	KCNK3	0.0006
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0006
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0006
1245	Vitamin K-dependent protein S	PROS1	0.0006
413	Amidophosphoribosyltransferase	PPAT	0.0006
2515	Amidophosphoribosyltransferase	purF	0.0006
3714	Amidophosphoribosyltransferase	purF	0.0006
422	Vitamin K-dependent protein C	PROC	0.0006
106	Cannabinoid receptor 2	CNR2	0.0006
6174	50S ribosomal protein L32	rpmF	0.0006
3809	Estrogen-related receptor gamma	ESRRG	0.0006
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0006
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0006
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0006
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0006
1196	Complement decay-accelerating factor	CD55	0.0006
3426	Glutamine synthetase	glnA	0.0006
3987	Glutamine synthetase	GLUL	0.0006
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0006
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0006
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0006
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0006
6168	Solute carrier family 22 member 16	SLC22A16	0.0006
3611	Cytidine deaminase	cdd	0.0006
3707	Cytidine deaminase	cdd	0.0006
4211	Cytidine deaminase	CDA	0.0006
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0006
1291	cAMP response element-binding protein	CREB1	0.0006
6163	Copper-transporting ATPase 2	ATP7B	0.0006
6165	Copper-transporting ATPase 1	ATP7A	0.0006
448	Vitamin K-dependent gamma-carboxylase	GGCX	0.0006
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0006
1569	G1/S-specific cyclin-D1	CCND1	0.0006
1525	Heparin-binding growth factor 2	FGF2	0.0006
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0006
4210	Toll-like receptor 4	TLR4	0.0005
2808	Chloramphenicol acetyltransferase 3	cat3	0.0005
1760	Aminopeptidase N	ANPEP	0.0005
6843	Aminopeptidase N	pepN	0.0005
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0005
3639	Thymidine phosphorylase	deoA	0.0005
3936	Thymidine phosphorylase	TYMP	0.0005
798	Osteocalcin	BGLAP	0.0005
6151	Monocarboxylate transporter 10	SLC16A10	0.0005
2207	Rhodopsin	RHO	0.0005
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0005
2417	Chloramphenicol acetyltransferase	cat	0.0005
3278	Chloramphenicol acetyltransferase	cat	0.0005
2810	Dr hemagglutinin structural subunit	draA	0.0005
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0005
3601	Dihydropteroate synthase 1	folP1	0.0005
3807	Dihydropteroate synthase 1	folP1	0.0005
3808	Dihydropteroate synthase 2	folP2	0.0005
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0005
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.0005
369	Coagulation factor VII	F7	0.0005
3913	Glutamic acid decarboxylase	GAD65	0.0005
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0004
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0004
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0004
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0004
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.0004
76	Nitric-oxide synthase, brain	NOS1	0.0004
4217	Telomerase reverse transcriptase	TERT	0.0004
735	Alanine aminotransferase 1	GPT	0.0004
3904	Alanine aminotransferase 2	GPT2	0.0004
1176	Mitogen-activated protein kinase 1	MAPK1	0.0004
594	Thyroxine-binding globulin	SERPINA7	0.0004
719	Retinoic acid receptor responder protein 1	RARRES1	0.0003
770	Retinoic acid-induced protein 3	GPRC5A	0.0003
758	Thyroid hormone receptor alpha	THRA	0.0003
2240	Cell division protein kinase 2	CDK2	0.0003
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0003
5798	Mitogen-activated protein kinase 11	MAPK11	0.0003
199	Monocarboxylate transporter 8	SLC16A2	0.0003
2320	Thymidine kinase, cytosolic	TK1	0.0003
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0003
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0003
569	Retinal dehydrogenase 2	ALDH1A2	0.0003
267	Plasminogen activator inhibitor 1	SERPINE1	0.0003
346	Thyroid hormone receptor beta-1	THRB	0.0003
611	Retinal dehydrogenase 1	ALDH1A1	0.0003
6221	Steroid hormone receptor ERR1	ESRRA	0.0003
6218	Pannexin-1	PANX1	0.0003
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0003
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0002
6135	Sodium channel subunit beta-4	SCN4B	0.0002
6134	Sodium channel subunit beta-3	SCN3B	0.0002
6132	Sodium channel subunit beta-1	SCN1B	0.0002
6127	Carbonic anhydrase-related protein	CA8	0.0002
6128	Carbonic anhydrase-related protein 10	CA10	0.0002
6133	Sodium channel subunit beta-2	SCN2B	0.0002
6129	Carbonic anhydrase-related protein 11	CA11	0.0002
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0002
3803	Sodium channel protein type 3 subunit alpha	SCN3A	0.0002
6130	Carbonic anhydrase 13	CA13	0.0002
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0002
489	Monocarboxylate transporter 2	SLC16A7	0.0002
3007	Carbonic anhydrase 12	CA12	0.0002
4205	Carbonic anhydrase 9	CA9	0.0002
4936	Cytochrome c2 iso-2	Not Available	0.0001
4916	Cyanoglobin	glbN	0.0001
4994	Hemoglobin-like protein HbO	glbO	0.0001
4915	Cytochrome c-550	psbV	0.0001
4959	Cytochrome c-550	psbV	0.0001
5216	Cytochrome c-550	psbV	0.0001
4925	Cytochrome c-type protein SHP	shp	0.0001
4904	Cytochrome c family protein	GSU1996	0.0001
4943	Cytochrome c6	petJ	0.0001
3116	Bacterioferritin	bfr	0.0001
4906	Bacterioferritin	bfr	0.0001
4965	Bacterioferritin	bfr	0.0001
4954	Soluble cytochrome b558	Not Available	0.0001
4934	Cytochrome c-551	nirM	0.0001
5218	Cytochrome c-551	nirM	0.0001
4905	Cytochrome c2	Not Available	0.0001
4939	Cytochrome c2	cycA	0.0001
4964	Cytochrome c2	cycA	0.0001
4979	Cytochrome c2	cycA	0.0001
6673	Cytochrome c2	cycA	0.0001
4910	Cytoglobin	CYGB	0.0001
4984	Neuroglobin	NGB	0.0001
4981	Iron-starvation protein PigA	pigA	0.0001
4909	CooA protein	cooA	0.0001
4998	Hemoglobin-like protein yjbI	yjbI	0.0001
4935	Cytochrome c-554	cycA1	0.0001
4947	Bacterial hemoglobin	vhb	0.0001
4975	Cytochrome c-556	RPA3973	0.0001
4942	Diheme cytochrome c napB	napB	0.0001
4931	Cytochrome P450 167A1	CYP167A1	0.0001
5000	HemO	hemO	0.0001
4972	P450cin	cinA	0.0001
4960	Putative cytochrome P450-family protein	SCO7417	0.0001
4971	Nonaheme cytochrome c	hmcA	0.0001
4989	Cytochrome c551 peroxidase	ccp	0.0001
5222	Cytochrome c551 peroxidase	ccpA	0.0001
4961	Hemophore HasA	hasA	0.0001
4976	Apocytochrome f	petA	0.0001
6407	Apocytochrome f	petA	0.0001
4907	Cytochrome c-L	moxG	0.0001
6865	Cytochrome c-L	moxG	0.0001
4993	Hydroxylamine oxidoreductase	hao1	0.0001
4764	Cytochrome P450 165C4	CYP165C4	0.0001
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0001
644	Heme oxygenase 2	HMOX2	0.0001
4982	Heme oxygenase 2	pbsA2	0.0001
4952	Catalase/peroxidase	katA	0.0001
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0001
4937	Cytochrome oxidase subunit II	rcoxA	0.0001
4903	Methyl-accepting chemotaxis protein	Tar4	0.0001
4999	Cytochrome P450 165B3	CYP165B3	0.0001
3093	Catalase HPII	katE	0.0001
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0001
4922	Cytochrome c, putative	SO_4144	0.0001
4920	Peroxidase/catalase	katG	0.0001
4990	PpcA	ppcA	0.0001
4948	Cytochrome c-553	Not Available	0.0001
4923	Cytochrome c3	DvMF_2499	0.0001
4945	Cytochrome c3	Not Available	0.0001
4949	Cytochrome c3	DVU_3171	0.0001
4968	Cytochrome c3	cytc3	0.0001
4997	Cytochrome c3	SO_2727	0.0001
5219	Cytochrome c3	cyd	0.0001
2119	Cytochrome b5	CYB5A	0.0001
4902	Nine-heme cytochrome c	Ddes_2038	0.0001
3189	High-molecular-weight cytochrome c	hmcA	0.0001
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0001
3375	Acidic cytochrome c3	Not Available	0.0001
4988	Sulfite oxidase, mitochondrial	SUOX	0.0001
2915	Sensor protein fixL	fixL	0.0001
4944	Sensor protein fixL	fixL	0.0001
4813	Heme oxygenase	hmuO	0.0001
5769	Heme oxygenase	Not Available	0.0001
3570	Cytochrome P450 152A1	cypC	0.0001
4385	Cytochrome c'	Not Available	0.0001
4967	Cytochrome c'	cycA	0.0001
5038	Cytochrome c'	Not Available	0.0001
5223	Cytochrome c'	cycP	0.0001
4037	Hypothetical protein	GPX1	0.0001
4297	Hypothetical protein	SP_1951	0.0001
4521	Hypothetical protein	BC_2969	0.0001
4540	Hypothetical protein	TM_1070	0.0001
4555	Hypothetical protein	MT1739	0.0001
4569	Hypothetical protein	mshD	0.0001
4578	Hypothetical protein	PA3270	0.0001
4747	Hypothetical protein	PA3967	0.0001
5177	Hypothetical protein	TM_0096	0.0001
5194	Hypothetical protein	PA1204	0.0001
5240	Hypothetical protein	Rv2991	0.0001
5370	Hypothetical protein	TM_1158	0.0001
5710	Hypothetical protein	Tb927.5.1360	0.0001
4289	Cytochrome P450	TT_P0059	0.0001
6262	Cytochrome P450	staP	0.0001
4992	Cytochrome c peroxidase	Not Available	0.0001
2230	Catalase	CAT	0.0001
3249	Catalase	katA	0.0001
3625	Catalase	katA	0.0001
4539	Catalase	katA	0.0001
4941	Catalase	katB	0.0001
3670	Soluble cytochrome b562 precursor	cybC	0.0001
3411	Cytochrome P450 121	cyp121	0.0001
3291	Cytochrome c-552	cycA	0.0001
4927	Cytochrome c-552	nrfA	0.0001
4938	Cytochrome c-552	cycA	0.0001
4953	Cytochrome c-552	nrfA	0.0001
5217	Cytochrome c-552	cycM	0.0001
2617	Nitric oxide synthase oxygenase	nos	0.0001
2701	Nitric oxide synthase oxygenase	nos	0.0001
3102	Flavohemoprotein	hmp	0.0001
4969	Flavohemoprotein	hmp	0.0001
4386	Hemoglobin-like protein HbN	glbN	0.0001
3127	Nitrite reductase	nirS	0.0001
3284	Nitrite reductase	nirS	0.0001
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0001
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0001
3221	Cytochrome c4	cc4	0.0001
4608	Putative cytochrome P450	SCO1207	0.0001
4963	Putative cytochrome P450	SCO2884	0.0001
6254	Putative cytochrome P450	SCO6998	0.0001
358	Cystathionine beta-synthase	CBS	0
1507	Cytochrome c	CYCS	0
693	Hemoglobin subunit beta	HBB	0
6268	Hydroxyacid oxidase 1	HAO1	0
810	Heme oxygenase 1	HMOX1	0
3391	Heme oxygenase 1	pbsA1	0

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB01012 - Cinacalcet

Targets

Enzymes

Predictions