DT-Web

DB00727 - Nitroglycerin


Identification
Name Nitroglycerin
Accession Number DB00727 (APRD00153)
Type small molecule
Description A volatile vasodilator which relieves angina pectoris by stimulating guanylate cyclase and lowering cytosolic calcium. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 227.0865
Groups approved
Monoisotopic Weight 227.002578773
Pharmacology
Indication For the prevention of angina
Mechanism of action Similar to other nitrites and organic nitrates, nitroglycerin is converted to nitric oxide (NO), an active intermediate compound which activates the enzyme guanylate cyclase. This stimulates the synthesis of cyclic guanosine 3',5'-monophosphate (cGMP) which then activates a series of protein kinase-dependent phosphorylations in the smooth muscle cells, eventually resulting in the dephosphorylation of the myosin light chain of the smooth muscle fiber. The subsequent release of calcium ions results in the relaxation of the smooth muscle cells and vasodilation.
Absorption Not Available
Protein binding Not Available
Biotransformation Hepatic, cytochrome P450 (P450) is a key enzyme of organic nitrate biotransformation
Route of elimination Not Available
Toxicity Increased intracranial pressure, with any or all of persistent throbbing headache, confusion, and moderate fever; Vertigo; Palpitations; Visual disturbances; Nausea and vomiting (possibly with colic and even bloody diarrhea); Syncope (especially in the upright posture); Air hunger and dyspnea, later followed by reduced ventilatory effort; Diaphoresis, with the skin either flushed or cold and clammy; Heart block and bradycardia; Paralysis; Coma; Seizures; Death.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Alteplase IV nitroglycerin may decrease the effect of alteplase.
Avanafil Additive vasodilation. Concomitant therapy is contraindicated.
Azilsartan medoxomil Pharmacodynamic synergist- increases effects.
Dihydroergotamine Possible antagonism of action
Dihydroergotoxine Possible antagonism of action
Ergonovine Possible antagonism of action
Ergotamine Possible antagonism of action
Methylergonovine Possible antagonism of action
Methysergide Possible antagonism of action
Sildenafil Possible significant hypotension with this combination
Tadalafil The vasodilatory effects of Nitroglycerin may be increased by Tadalafil. Severe hypotension may occur. Concomitant therapy is contraindicated.
Treprostinil Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.
Udenafil The vasodilatory effects of Nitroglycerin may be increased by Udenafil. Severe hypotension may occur. Concomitant therapy is contraindicated.
Vardenafil The vasodilatory effects of Nitroglycerin may be increased by Vardenafil. Severe hypotension may occur. Concomitant therapy is contraindicated.
Food Interactions
  • Dissolve under the tongue.
  • Take on empty stomach: 1 hour before or 2 hours after meals.
  • Avoid alcohol.

Targets


Atrial natriuretic peptide receptor A
Name Atrial natriuretic peptide receptor A
Gene Name NPR1
Pharmacological action yes
Actions agonist
References
  • Madhani M, Scotland RS, MacAllister RJ, Hobbs AJ: Vascular natriuretic peptide receptor-linked particulate guanylate cyclases are modulated by nitric oxide-cyclic GMP signalling. Br J Pharmacol. 2003 Aug;139(7):1289-96. - Pubmed
  • Bauersachs J: Aminoethyl nitrate--the novel super nitrate? Br J Pharmacol. 2009 Sep;158(2):507-9. - Pubmed
DTHybrid score 0.8472

Enzymes


Aldehyde dehydrogenase, mitochondrial
Name Aldehyde dehydrogenase, mitochondrial
Gene Name ALDH2
Actions substrate
References
  • Badejo AM Jr, Hodnette C, Dhaliwal JS, Casey DB, Pankey E, Murthy SN, Nossaman BD, Hyman AL, Kadowitz PJ: Mitochondrial aldehyde dehydrogenase mediates vasodilator responses of glyceryl trinitrate and sodium nitrite in the pulmonary vascular bed of the rat. Am J Physiol Heart Circ Physiol. 2010 Sep;299(3):H819-26. Epub 2010 Jun 11. - Pubmed
DTHybrid score 0.6624

Predictions


Id Partner name Gene Name Score
1465 Atrial natriuretic peptide receptor B NPR2 0.2799
4193 Atrial natriuretic peptide clearance receptor NPR3 0.1178
6013 Cytochrome P450 2E1 CYP2E1 0.0546
4512 Cytochrome P450 3A4 CYP3A4 0.0511
4200 Cytochrome P450 1A2 CYP1A2 0.0499
6024 Cytochrome P450 1A1 CYP1A1 0.0458
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0374
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0316
6030 Cytochrome P450 2B6 CYP2B6 0.0224
153 Dopamine beta-hydroxylase DBH 0.0223
5126 Arginase rocF 0.0151
740 Argininosuccinate synthase ASS1 0.0141
865 Argininosuccinate synthase ASS1 0.0141
2680 Argininosuccinate synthase argG 0.0141
3194 Argininosuccinate synthase argG 0.0141
624 Guanidinoacetate N-methyltransferase GAMT 0.0122
4118 Cytochrome P450 3A5 CYP3A5 0.0107
4757 Cytochrome P450 2C9 CYP2C9 0.0097
5682 Ribonuclease pancreatic RNASE1 0.0088
2300 Lysozyme E 0.0086
3633 Lysozyme R 0.0086
5597 Lysozyme 17 0.0086
4924 Cytochrome P450 2C8 CYP2C8 0.0079
833 Organic cation/carnitine transporter 1 SLC22A4 0.0077
6147 Solute carrier family 22 member 3 SLC22A3 0.0076
4119 Cytochrome P450 2D6 CYP2D6 0.0071
118 Organic cation/carnitine transporter 2 SLC22A5 0.0067
6144 Solute carrier family 22 member 2 SLC22A2 0.0066
6145 Solute carrier family 22 member 1 SLC22A1 0.0064
6142 Solute carrier family 22 member 8 SLC22A8 0.0063
316 4-trimethylaminobutyraldehyde dehydrogenase ALDH9A1 0.0027
792 Aldehyde dehydrogenase, dimeric NADP-preferring ALDH3A1 0.0027
816 Biliverdin reductase A BLVRA 0.0027
579 Alcohol dehydrogenase class 4 mu/sigma chain ADH7 0.0027
646 Malate dehydrogenase, cytoplasmic MDH1 0.0024
350 3-hydroxyacyl-CoA dehydrogenase type-2 HSD17B10 0.0024
812 Dihydrolipoyl dehydrogenase, mitochondrial DLD 0.0024
178 NADH-cytochrome b5 reductase 3 CYB5R3 0.0024
454 Peroxisomal multifunctional enzyme type 2 HSD17B4 0.0024
597 Dihydropteridine reductase QDPR 0.0024
396 Alcohol dehydrogenase 4 ADH4 0.0024
328 Sorbitol dehydrogenase SORD 0.0024
363 NADP-dependent malic enzyme, mitochondrial ME3 0.0024
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.0023
419 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial HADH 0.0023
12 Alcohol dehydrogenase class 3 ADH5 0.0023
77 L-lactate dehydrogenase B chain LDHB 0.0022
569 Retinal dehydrogenase 2 ALDH1A2 0.0022
599 Glyceraldehyde-3-phosphate dehydrogenase GAPDH 0.0022
4426 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0022
4454 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0022
4489 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0022
473 L-lactate dehydrogenase A chain LDHA 0.0021
794 Glyceraldehyde-3-phosphate dehydrogenase, testis-specific GAPDHS 0.0021
611 Retinal dehydrogenase 1 ALDH1A1 0.0021
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0021
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0021
166 NAD-dependent malic enzyme, mitochondrial ME2 0.002
251 Alcohol dehydrogenase 1A ADH1A 0.0019
4423 Levodione reductase lvr 0.0019
4456 Inorganic polyphosphate/ATP-NAD kinase ppnK 0.0019
4428 Redox-sensing transcriptional repressor rex rex 0.0019
4447 Hypothetical protein yhfP yhfP 0.0019
4449 ADP-ribosyltransferase Not Available 0.0019
4475 Hypothetical protein Rv0046c/MT0052 ino1 0.0019
4455 Glycerol dehydrogenase gldA 0.0019
4495 3-oxoacyl-(Acyl carrier protein) reductase TM_1169 0.0019
4435 L-aspartate dehydrogenase nadX 0.0019
4466 Glutathione-independent formaldehyde dehydrogenase fdhA 0.0019
4446 3alpha-hydroxysteroid dehydrogenase/carbonyl reductase Not Available 0.0019
4487 Transcriptional regulator nadR nadR 0.0019
4505 Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase bphB 0.0019
3735 NAD(P) transhydrogenase subunit alpha part 1 pntAA 0.0019
4500 L-lactate dehydrogenase 2 ldh2 0.0019
4336 Glyceraldehyde 3-phosphate dehydrogenase Not Available 0.0019
4436 Glyceraldehyde 3-phosphate dehydrogenase tthHB8IM 0.0019
3381 Alcohol dehydrogenase Not Available 0.0019
4508 Alcohol dehydrogenase adhA 0.0019
4414 Dehydrogenase TT_P0035 0.0019
2350 3-isopropylmalate dehydrogenase leuB 0.0019
3092 3-isopropylmalate dehydrogenase leuB 0.0019
4471 CDP-D-glucose-4,6-dehydratase ascB 0.0019
4418 AGR_L_3209p AGR_L_3209 0.0019
4507 Alanine dehydrogenase ald 0.0019
4443 Quinate/shikimate dehydrogenase ydiB 0.0019
4497 Benzyl alcohol dehydrogenase xylB 0.0019
4506 Myo-inositol-1-phosphate synthase-related protein TM_1419 0.0019
4502 Formate dehydrogenase Not Available 0.0019
3729 Citrate synthase gltA 0.0019
4575 Citrate synthase cit 0.0019
4580 Citrate synthase gltA 0.0019
4451 Vip2Ac vip2Ac 0.0019
4472 Glucose 1-dehydrogenase Not Available 0.0019
4467 Alpha-glucosidase, putative TM_0752 0.0019
4448 L-2-hydroxyisocaproate dehydrogenase Not Available 0.0019
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0019
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0018
444 Alcohol dehydrogenase 1B ADH1B 0.0018
714 Glutathione reductase, mitochondrial GSR 0.0017
517 Alcohol dehydrogenase 1C ADH1C 0.0015
4484 2,5-diketo-D-gluconic acid reductase A dkgA 0.0015
4486 Phenol 2-hydroxylase component B pheA2 0.0015
4439 Ferredoxin reductase bphA4 0.0015
4477 Dihydrolipoyl dehydrogenase lpdV 0.0015
5077 Dihydrolipoyl dehydrogenase Not Available 0.0015
5117 Dihydrolipoyl dehydrogenase lpd 0.0015
3598 dTDP-4-dehydrorhamnose reductase rfbD 0.0015
4427 TDP-glucose-4,6-dehydratase desIV 0.0015
3177 dTDP-glucose 4,6-dehydratase rfbB 0.0015
4499 dTDP-glucose 4,6-dehydratase rmlB 0.0015
4503 NADPH-flavin oxidoreductase frp 0.0015
4482 UDP-galactose 4-epimerase galE 0.0015
2967 CDP-paratose 2-epimerase rfbE 0.0015
2507 Diphtheria toxin Not Available 0.0015
2538 6-phospho-beta-glucosidase bglT bglT 0.0015
2393 Maltose-6'-phosphate glucosidase glvA 0.0015
2018 Deoxyhypusine synthase DHPS 0.0015
4509 Acetoin(diacetyl) reductase budC 0.0015
3671 7-alpha-hydroxysteroid dehydrogenase hdhA 0.0015
2881 Gamma-aminobutyraldehyde dehydrogenase prr 0.0015
3401 D-2-hydroxyisocaproate dehydrogenase Not Available 0.0015
3081 3-dehydroquinate synthase aroB 0.0015
126 D-lactate dehydrogenase dld 0.0015
3545 D-lactate dehydrogenase Not Available 0.0015
4510 D-lactate dehydrogenase ldhA 0.0015
2591 Urocanate hydratase hutU 0.0015
3615 Dihydrodipicolinate reductase dapB 0.0015
3618 Dihydrodipicolinate reductase dapB 0.0015
4462 Dihydrodipicolinate reductase dapB 0.0015
4498 Ornithine cyclodeaminase PP3533 0.0015
2831 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase Not Available 0.0015
3059 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase fabG3 0.0015
2424 L-lactate dehydrogenase ldh 0.0015
2641 L-lactate dehydrogenase Not Available 0.0015
4437 L-lactate dehydrogenase ldh 0.0015
4442 L-lactate dehydrogenase ldh 0.0015
1199 GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1 ART1 0.0015
4450 Iota toxin component Ia Not Available 0.0015
6698 Dehydrogenase/reductase SDR family member 4-like 2 DHRS4L2 0.0015
3087 Nicotinate-nucleotide adenylyltransferase nadD 0.0015
4469 Nicotinate-nucleotide adenylyltransferase nadD 0.0015
4496 C-terminal-binding protein 1 CTBP1 0.0015
2336 2,3-diketo-L-gulonate reductase dlgD 0.0015
2683 Mono-ADP-ribosyltransferase C3 C3 0.0014
4476 Mannitol dehydrogenase mtlD 0.0014
63 Malate dehydrogenase mdh 0.0014
2329 Malate dehydrogenase mdh 0.0014
3445 Malate dehydrogenase mdh 0.0014
4420 Malate dehydrogenase mdh 0.0014
4438 Malate dehydrogenase mdh 0.0014
531 Aldehyde dehydrogenase X, mitochondrial ALDH1B1 0.0013
4504 WbpP Not Available 0.0013
3296 Nicotinamide mononucleotide adenylyltransferase 1 NMNAT1 0.0013
3367 GDP-mannose 6-dehydrogenase algD 0.0013
4318 Siroheme synthase cysG 0.0013
4440 NADH peroxidase npr 0.0013
3736 Glyceraldehyde-3-phosphate dehydrogenase A gapA 0.0013
2799 Glyceraldehyde-3-phosphate dehydrogenase, glycosomal Not Available 0.0013
4343 Alpha-glucosidase aglA 0.0013
2617 Nitric oxide synthase oxygenase nos 0.0013
2701 Nitric oxide synthase oxygenase nos 0.0013
247 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 NDUFA1 0.0012
662 Fatty aldehyde dehydrogenase ALDH3A2 0.0012
104 NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial NDUFS6 0.0012
190 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4 NDUFA4 0.0012
417 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 NDUFB6 0.0012
216 Aldehyde dehydrogenase 3B2 ALDH3B2 0.0012
607 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 NDUFA2 0.0012
300 NADH-ubiquinone oxidoreductase chain 4L MT-ND4L 0.0012
374 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 NDUFB1 0.0012
99 NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 NDUFS5 0.0012
30 NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial NDUFV3 0.0012
446 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 NDUFA7 0.0012
496 Aldehyde dehydrogenase 3B1 ALDH3B1 0.0012
324 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 NDUFB4 0.0012
258 Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial ALDH6A1 0.0012
343 NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial NDUFC1 0.0012
568 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 NDUFB7 0.0012
598 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 NDUFA11 0.0012
271 Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial ALDH4A1 0.0012
829 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 NDUFA12 0.0012
755 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 NDUFA3 0.0012
353 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 NDUFA4L2 0.0012
272 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 NDUFB10 0.0012
313 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 NDUFB3 0.0012
555 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial NDUFS4 0.0012
746 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial NDUFB8 0.0012
475 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial NDUFB2 0.0012
644 Heme oxygenase 2 HMOX2 0.0012
4982 Heme oxygenase 2 pbsA2 0.0012
525 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 NDUFA5 0.0012
219 NADH-ubiquinone oxidoreductase chain 3 MT-ND3 0.0012
41 NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial NDUFS8 0.0012
236 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 NDUFA6 0.0012
270 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial NDUFB5 0.0012
112 L-lactate dehydrogenase A-like 6B LDHAL6B 0.0012
152 NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial NDUFV2 0.0012
848 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial IDH3G 0.0012
582 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 NDUFA13 0.0012
196 D-beta-hydroxybutyrate dehydrogenase, mitochondrial BDH1 0.0012
327 Glutathione reductase gor 0.0012
5110 Glutathione reductase GR2 0.0012
602 Acyl carrier protein, mitochondrial NDUFAB1 0.0012
107 C-4 methylsterol oxidase SC4MOL 0.0012
608 NADH-ubiquinone oxidoreductase chain 4 MT-ND4 0.0012
405 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 NDUFA8 0.0012
384 NADH-ubiquinone oxidoreductase chain 6 MT-ND6 0.0012
372 Estradiol 17-beta-dehydrogenase 3 HSD17B3 0.0012
145 Corticosteroid 11-beta-dehydrogenase isozyme 2 HSD11B2 0.0012
656 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 NDUFB9 0.0012
729 GDP-L-fucose synthetase TSTA3 0.0012
3463 GDP-L-fucose synthetase fcl 0.0012
487 Aldo-keto reductase family 1 member C4 AKR1C4 0.0012
149 Alpha-aminoadipic semialdehyde dehydrogenase ALDH7A1 0.0012
167 L-lactate dehydrogenase C chain LDHC 0.0012
326 L-lactate dehydrogenase A-like 6A LDHAL6A 0.0012
141 3-hydroxyisobutyrate dehydrogenase, mitochondrial HIBADH 0.0012
180 D-3-phosphoglycerate dehydrogenase PHGDH 0.0012
3726 D-3-phosphoglycerate dehydrogenase serA 0.0012
4291 D-3-phosphoglycerate dehydrogenase serA 0.0012
206 3-keto-steroid reductase HSD17B7 0.0012
721 NADH-ubiquinone oxidoreductase chain 2 MT-ND2 0.0012
231 Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic GPD1 0.0012
91 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial NDUFA10 0.0012
14 Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial IDH3A 0.0012
50 Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating NSDHL 0.0012
335 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial NDUFA9 0.0012
616 Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial IDH3B 0.0012
9 Estradiol 17-beta-dehydrogenase 2 HSD17B2 0.0012
671 Pyruvate dehydrogenase E1 component alpha subunit, testis-specific form, mitochondrial PDHA2 0.0012
628 Pyruvate dehydrogenase E1 component alpha subunit, somatic form, mitochondrial PDHA1 0.0012
539 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial NDUFV1 0.0012
548 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial NDUFS1 0.0012
609 15-hydroxyprostaglandin dehydrogenase [NAD+] HPGD 0.0012
34 7-dehydrocholesterol reductase DHCR7 0.0012
711 UDP-glucose 6-dehydrogenase UGDH 0.0012
3672 UDP-glucose 6-dehydrogenase hasB 0.0012
637 NADH-ubiquinone oxidoreductase chain 5 MT-ND5 0.0012
643 Peroxisomal bifunctional enzyme EHHADH 0.0012
288 Trifunctional enzyme subunit alpha, mitochondrial HADHA 0.0012
393 GDH/6PGL endoplasmic bifunctional protein [Includes: Glucose 1-dehydrogenase H6PD 0.0012
1799 Glucose-6-phosphate 1-dehydrogenase G6PD 0.0012
2630 Glucose-6-phosphate 1-dehydrogenase zwf 0.0012
3333 Nicotinamide mononucleotide adenylyltransferase 3 NMNAT3 0.0012
2434 NH(3)-dependent NAD(+) synthetase nadE 0.0012
2910 NH(3)-dependent NAD(+) synthetase nadE 0.0012
3217 NH(3)-dependent NAD(+) synthetase nadE 0.0012
2826 Glucose--fructose oxidoreductase gfo 0.0012
3070 Adenosylhomocysteinase AHCY 0.0012
4424 Adenosylhomocysteinase PFE1050w 0.0012
6278 Adenosylhomocysteinase ahcY 0.0012
5325 2,4-dienoyl-CoA reductase, mitochondrial DECR1 0.0012
3191 Histidinol dehydrogenase hisD 0.0012
635 Estradiol 17-beta-dehydrogenase 8 HSD17B8 0.0012
666 NADP-dependent malic enzyme ME1 0.0012
857 Malate dehydrogenase, mitochondrial MDH2 0.0011
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0011
640 Aldehyde dehydrogenase 1A3 ALDH1A3 0.0011
11 NAD(P) transhydrogenase, mitochondrial NNT 0.0011
839 Short-chain specific acyl-CoA dehydrogenase, mitochondrial ACADS 0.0011
74 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial DLAT 0.0011
2286 Isocitrate dehydrogenase [NADP] icd 0.0011
2302 Isocitrate dehydrogenase [NADP] icd 0.0011
2771 Isocitrate dehydrogenase [NADP] icd 0.0011
4491 DNA ligase, NAD-dependent ligA 0.0011
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0011
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0011
296 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial MTHFD2 0.0011
6026 Alcohol dehydrogenase 6 ADH6 0.001
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.001
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.001
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.001
627 11-cis retinol dehydrogenase RDH5 0.001
626 Cysteine dioxygenase type 1 CDO1 0.001
110 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial PDHB 0.001
248 Pyrroline-5-carboxylate reductase 1 PYCR1 0.001
802 Pyrroline-5-carboxylate reductase 2 PYCR2 0.001
2762 UDP-glucose 4-epimerase GALE 0.001
3461 UDP-glucose 4-epimerase galE 0.001
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.001
13 Aminomethyltransferase, mitochondrial AMT 0.001
83 Alpha-aminoadipic semialdehyde synthase, mitochondrial AASS 0.001
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.001
679 C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 0.001
57 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I HSD3B1 0.0009
654 Flavin reductase BLVRB 0.0009
279 Tyrosinase TYR 0.0009
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0009
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0009
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0009
810 Heme oxygenase 1 HMOX1 0.0009
3391 Heme oxygenase 1 pbsA1 0.0009
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0009
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0009
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0009
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0009
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0008
380 Cytochrome P450 17A1 CYP17A1 0.0008
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0008
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0008
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0008
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0008
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0008
468 Cytochrome P450 4A11 CYP4A11 0.0008
6020 Aldehyde oxidase AOX1 0.0007
822 Aldose reductase AKR1B1 0.0007
365 Dihydrofolate reductase DHFR 0.0007
2381 Dihydrofolate reductase DFR1 0.0007
2833 Dihydrofolate reductase Not Available 0.0007
2931 Dihydrofolate reductase folA 0.0007
3544 Dihydrofolate reductase folA 0.0007
3682 Dihydrofolate reductase folA 0.0007
6642 Dihydrofolate reductase folA 0.0007
6756 Dihydrofolate reductase dfrA 0.0007
3947 Xanthine dehydrogenase/oxidase XDH 0.0007
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