DT-Web

DB00379 - Mexiletine


Identification
Name Mexiletine
Accession Number DB00379 (APRD00242)
Type small molecule
Description Antiarrhythmic agent pharmacologically similar to lidocaine. It may have some anticonvulsant properties. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 179.2588
Groups approved
Monoisotopic Weight 179.131014171
Pharmacology
Indication For the treatment of ventricular tachycardia and symptomatic premature ventricular beats, and prevention of ventricular fibrillation.
Mechanism of action Mexiletine, like lidocaine, inhibits the inward sodium current required for the initiation and conduction of impulses, thus reducing the rate of rise of the action potential, Phase 0. It achieves this reduced sodium current by inhibiting sodium channels. Mexiletine decreases the effective refractory period (ERP) in Purkinje fibers in the heart. The decrease in ERP is of lesser magnitude than the decrease in action potential duration (APD), which results in an increase in the ERP/APD ratio. It does not significantly affect resting membrane potential or sinus node automaticity, left ventricular function, systolic arterial blood pressure, atrioventricular (AV) conduction velocity, or QRS or QT intervals
Absorption Well absorbed (bioavailability 90%) from the gastrointenstinal tract.
Protein binding 50-60%
Biotransformation Primarily hepatic (85%) via CYP2D6 and CYP1A2 (primarily CYP2D6).
Route of elimination Approximately 10% is excreted unchanged by the kidney. The urinary excretion of N-methylmexiletine in man is less than 0.5%.
Toxicity Symptoms of overdose include nausea, hypotension, sinus bradycardia, paresthesia, seizures, bundle branch block, AV heart block, asystole, ventricular tachyarrythmia, including ventricular fibrillation, cardiovascular collapse, and coma.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Aminophylline Mexiletine increases the effect and toxicity of theophylline
Bendamustine Affects hepatic CYP1A2 metabolism, thus increasing bendamustine levels. Concentration of active metabolites may be decreased due to decreased conversion.
Dyphylline Mexiletine increases the effect and toxicity of theophylline
Eltrombopag Affects hepatic CYP1A2 metabolism, increases Eltrombopag level or affect.
Ethotoin The hydantoin decreases the effect of mexiletine
Etravirine Mexiletine, when used concomitantly with etravirine (a strong CYP3A4 inducer), may experience a decrease in serum concentration. It is recommended to monitor mexiletine therapy for reduced effectiveness.
Fluvoxamine Fluvoxamine may increase the therapeutic and adverse effects of mexiletine.
Fosphenytoin The hydantoin decreases the effect of mexiletine
Mephenytoin The hydantoin decreases the effect of mexiletine
Oxtriphylline Mexiletine increases the effect and toxicity of theophylline
Phenytoin The hydantoin decreases the effect of mexiletine
Propafenone Propafenone may increase the effect and toxicity of mexilitine.
Ramelteon Mexiletine increases levels/toxicity of ramelteon
Rifampin Rifampin decreases the effect of mexiletine
Tacrine The metabolism of Tacrine, a CYP1A2 substrate, may be reduced by strong CYP1A2 inhibitors such as Mexiletine. Consider modifying therapy to avoid Tacrine toxicity. Monitor the efficacy and toxicity of Tacrine if Mexiletine is initiated, discontinued or if the dose is changed.
Terbinafine Terbinafine may reduce the metabolism and clearance of Mexiletine. Consider alternate therapy or monitor for therapeutic/adverse effects of Mexiletine if Terbinafine is initiated, discontinued or dose changed.
Terfenadine Increased risk of cardiotoxicity and arrhythmias
Theophylline Mexiletine increases the effect and toxicity of theophylline
Thiothixene The strong CYP1A2 inhibitor, Mexiletine, may decrease the metabolism and clearance of Thiothixene, a CYP1A2 substrate. Consider alternate therapy or monitor for changes in Thiothixene therapeutic and adverse effects if Mexiletine is initiated, discontinued or dose changed.
Tizanidine Mexilitene may decrease the metabolism and clearance of Tizanidine. Consider alternate therapy or use caution during co-administration.
Vilazodone Monitor for increased serum concentrations/toxic effects of mexiletine if a selective serotonin reuptake inhibitor (SSRI) is initiated/dose increased, or decreased concentrations/effects if an SSRI is discontinued/dose decreased.
Food Interactions
  • Take with food to reduce irritation.

Targets


Sodium channel protein type 5 subunit alpha
Name Sodium channel protein type 5 subunit alpha
Gene Name SCN5A
Pharmacological action yes
Actions inhibitor
References
  • Valdivia CR, Ackerman MJ, Tester DJ, Wada T, McCormack J, Ye B, Makielski JC: A novel SCN5A arrhythmia mutation, M1766L, with expression defect rescued by mexiletine. Cardiovasc Res. 2002 Aug 1;55(2):279-89. - Pubmed
  • Chinushi M, Tagawa M, Sugiura H, Komura S, Hosaka Y, Washizuka T, Aizawa Y: Ventricular tachyarrhythmias in a canine model of LQT3: arrhythmogenic effects of sympathetic activity and therapeutic effects of mexiletine. Circ J. 2003 Mar;67(3):263-8. - Pubmed
  • Fabritz L, Kirchhof P, Franz MR, Nuyens D, Rossenbacker T, Ottenhof A, Haverkamp W, Breithardt G, Carmeliet E, Carmeliet P: Effect of pacing and mexiletine on dispersion of repolarisation and arrhythmias in DeltaKPQ SCN5A (long QT3) mice. Cardiovasc Res. 2003 Mar 15;57(4):1085-93. - Pubmed
  • Wang HW, Zheng YQ, Yang ZF, Li CZ, Liu YM: Effect of mexiletine on long QT syndrome model. Acta Pharmacol Sin. 2003 Apr;24(4):316-20. - Pubmed
  • Napolitano C, Bloise R, Priori SG: Gene-specific therapy for inherited arrhythmogenic diseases. Pharmacol Ther. 2006 Apr;110(1):1-13. Epub 2005 Sep 15. - Pubmed
  • Shimizu W, Antzelevitch C, Suyama K, Kurita T, Taguchi A, Aihara N, Takaki H, Sunagawa K, Kamakura S: Effect of sodium channel blockers on ST segment, QRS duration, and corrected QT interval in patients with Brugada syndrome. J Cardiovasc Electrophysiol. 2000 Dec;11(12):1320-9. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 0.5041
Aryl hydrocarbon receptor
Name Aryl hydrocarbon receptor
Gene Name AHR
Pharmacological action unknown
Actions agonist
References
  • Hu W, Sorrentino C, Denison MS, Kolaja K, Fielden MR: Induction of cyp1a1 is a nonspecific biomarker of aryl hydrocarbon receptor activation: results of large scale screening of pharmaceuticals and toxicants in vivo and in vitro. Mol Pharmacol. 2007 Jun;71(6):1475-86. Epub 2007 Feb 27. - Pubmed
DTHybrid score 0.2728

Enzymes


Cytochrome P450 1A2
Name Cytochrome P450 1A2
Gene Name CYP1A2
Actions substrate,inhibitor
References
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
  • Nakajima M, Kobayashi K, Shimada N, Tokudome S, Yamamoto T, Kuroiwa Y: Involvement of CYP1A2 in mexiletine metabolism. Br J Clin Pharmacol. 1998 Jul;46(1):55-62. - Pubmed
DTHybrid score 0.4465
Cytochrome P450 2D6
Name Cytochrome P450 2D6
Gene Name CYP2D6
Actions substrate
References
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
  • Nakajima M, Kobayashi K, Shimada N, Tokudome S, Yamamoto T, Kuroiwa Y: Involvement of CYP1A2 in mexiletine metabolism. Br J Clin Pharmacol. 1998 Jul;46(1):55-62. - Pubmed
DTHybrid score 0.4779
Cytochrome P450 2B6
Name Cytochrome P450 2B6
Gene Name CYP2B6
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3178
Cytochrome P450 2E1
Name Cytochrome P450 2E1
Gene Name CYP2E1
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.2886
Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.5728

Predictions


Id Partner name Gene Name Score
4757 Cytochrome P450 2C9 CYP2C9 0.273
6016 Cytochrome P450 2C19 CYP2C19 0.2621
4118 Cytochrome P450 3A5 CYP3A5 0.1825
4924 Cytochrome P450 2C8 CYP2C8 0.181
1588 Multidrug resistance protein 1 ABCB1 0.1804
1159 Interleukin-6 IL6 0.1354
6024 Cytochrome P450 1A1 CYP1A1 0.1343
6107 Cytochrome P450 3A7 CYP3A7 0.1207
5718 Cytochrome P450 2A6 CYP2A6 0.1011
587 Serum albumin ALB 0.0775
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.076
492 Histamine H1 receptor HRH1 0.0678
290 Prostaglandin G/H synthase 2 PTGS2 0.0669
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0649
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0607
824 Sodium-dependent serotonin transporter SLC6A4 0.0598
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0516
20 Prostaglandin G/H synthase 1 PTGS1 0.0488
1898 Cytochrome P450 1B1 CYP1B1 0.0486
502 5-hydroxytryptamine 2A receptor HTR2A 0.0469
556 Alpha-1A adrenergic receptor ADRA1A 0.0462
831 D(2) dopamine receptor DRD2 0.0459
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0458
6106 Cytochrome P450 2C18 CYP2C18 0.0451
465 Calmodulin CALM1 0.0449
3811 Cytochrome P450 19A1 CYP19A1 0.0426
992 Protein tyrosine kinase 2 beta PTK2B 0.0424
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0422
6145 Solute carrier family 22 member 1 SLC22A1 0.0421
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.04
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0396
6144 Solute carrier family 22 member 2 SLC22A2 0.0377
862 Multidrug resistance-associated protein 1 ABCC1 0.0377
318 Alpha-2A adrenergic receptor ADRA2A 0.0369
713 Sodium-dependent dopamine transporter SLC6A3 0.0355
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.035
118 Organic cation/carnitine transporter 2 SLC22A5 0.0345
51 Muscarinic acetylcholine receptor M3 CHRM3 0.034
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0334
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0329
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0325
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0324
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0321
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0316
3923 Cholinesterase BCHE 0.0314
590 5-hydroxytryptamine 2C receptor HTR2C 0.0309
23 D(1A) dopamine receptor DRD1 0.0303
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0301
320 5-hydroxytryptamine 1A receptor HTR1A 0.0294
766 Beta-2 adrenergic receptor ADRB2 0.0288
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0287
193 Beta-1 adrenergic receptor ADRB1 0.0279
3941 Amine oxidase [flavin-containing] A MAOA 0.0277
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0275
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0272
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0269
847 Mu-type opioid receptor OPRM1 0.0266
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0265
632 Alpha-1B adrenergic receptor ADRA1B 0.026
36 Insulin receptor INSR 0.0258
1729 Solute carrier family 22 member 6 SLC22A6 0.0257
146 Androgen receptor AR 0.0254
341 5-hydroxytryptamine 3 receptor HTR3A 0.0252
833 Organic cation/carnitine transporter 1 SLC22A4 0.0246
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0244
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0238
136 Estrogen receptor ESR1 0.0234
260 Cytochrome P450 51 ERG11 0.0233
761 Cytochrome P450 51 ERG11 0.0233
3163 Cytochrome P450 51 cyp51 0.0233
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0233
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0232
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0232
776 Bile salt export pump ABCB11 0.0229
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0227
731 HIV-1 protease HIV-1 protease 0.022
885 5-hydroxytryptamine 1B receptor HTR1B 0.0215
2164 Multidrug resistance-associated protein 4 ABCC4 0.0213
6147 Solute carrier family 22 member 3 SLC22A3 0.0212
871 Glucocorticoid receptor NR3C1 0.0211
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0211
638 D(3) dopamine receptor DRD3 0.0209
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0208
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0205
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0203
467 Delta-type opioid receptor OPRD1 0.0203
3939 Amine oxidase [flavin-containing] B MAOB 0.0201
468 Cytochrome P450 4A11 CYP4A11 0.02
817 DNA topoisomerase 2-alpha TOP2A 0.0195
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0194
696 Kappa-type opioid receptor OPRK1 0.0189
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0185
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0185
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0182
789 Alpha-1D adrenergic receptor ADRA1D 0.0179
737 Mineralocorticoid receptor NR3C2 0.0175
725 5-hydroxytryptamine 1D receptor HTR1D 0.0174
172 Potassium channel subfamily K member 1 KCNK1 0.0174
629 Alpha-2B adrenergic receptor ADRA2B 0.0174
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0172
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0169
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0167
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0167
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0161
378 Alpha-2C adrenergic receptor ADRA2C 0.016
16 Adenosine A1 receptor ADORA1 0.0157
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0156
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0155
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0155
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0153
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0153
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.015
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0149
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0149
432 D(4) dopamine receptor DRD4 0.0148
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0147
482 Glycine receptor subunit alpha-1 GLRA1 0.0147
6142 Solute carrier family 22 member 8 SLC22A8 0.0147
6031 Cytochrome P450 3A43 CYP3A43 0.0147
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0146
477 DNA topoisomerase 4 subunit A parC 0.0146
886 DNA topoisomerase 4 subunit A parC 0.0146
6226 DNA topoisomerase 4 subunit A parC 0.0146
404 DNA gyrase subunit A gyrA 0.0144
6224 DNA gyrase subunit A gyrA 0.0144
6136 Multidrug resistance-associated protein 5 ABCC5 0.0143
921 Glutamate receptor 2 GRIA2 0.0136
122 P2Y purinoceptor 12 P2RY12 0.0136
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0134
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0133
705 Glutamate receptor 1 GRIA1 0.0132
1178 Adenosine A2a receptor ADORA2A 0.0131
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0127
537 ATP synthase delta chain, mitochondrial ATP5D 0.0127
952 Dipeptidyl peptidase 4 DPP4 0.0123
436 5-hydroxytryptamine 2B receptor HTR2B 0.0122
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0121
818 50S ribosomal protein L10 rplJ 0.0121
442 Envelope glycoprotein gp41 0.012
4859 Envelope glycoprotein env 0.012
33 Cystine/glutamate transporter SLC7A11 0.0118
6143 Solute carrier family 22 member 7 SLC22A7 0.0117
777 Tumor necrosis factor TNF 0.0117
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0116
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0114
3947 Xanthine dehydrogenase/oxidase XDH 0.0113
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.0113
94 5-hydroxytryptamine 4 receptor HTR4 0.011
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0109
613 Atrial natriuretic peptide receptor A NPR1 0.0106
174 Sigma 1-type opioid receptor SIGMAR1 0.0105
1010 Cytochrome P450 51A1 CYP51A1 0.0104
716 5-hydroxytryptamine 7 receptor HTR7 0.0104
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0103
163 D(1B) dopamine receptor DRD5 0.0102
474 Acetylcholinesterase ACHE 0.0102
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0102
4604 Liver carboxylesterase 1 CES1 0.0101
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0101
6014 Cytochrome P450 2A13 CYP2A13 0.0101
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.01
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.01
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.01
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.01
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0099
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0097
958 Insulin-like growth factor 1 receptor IGF1R 0.0097
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0097
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0097
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0096
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0096
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0096
844 Epidermal growth factor receptor EGFR 0.0096
6148 Multidrug resistance-associated protein 7 ABCC10 0.0096
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0095
811 Translocator protein TSPO 0.0095
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0094
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0094
6020 Aldehyde oxidase AOX1 0.0093
232 Corticosteroid-binding globulin SERPINA6 0.0093
1757 Myeloperoxidase MPO 0.0091
1656 CYP2B protein CYP2B 0.0091
504 Mast/stem cell growth factor receptor KIT 0.0091
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0091
6182 Cytochrome P450 2J2 CYP2J2 0.0091
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0091
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0089
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0088
891 Dihydropteroate synthase folP 0.0088
5359 Dihydropteroate synthase folP 0.0088
7175 Dihydropteroate synthase sulI 0.0088
4122 Histone deacetylase 2 HDAC2 0.0088
4120 NADPH--cytochrome P450 reductase POR 0.0088
161 Tubulin beta chain TUBB 0.0087
312 Tubulin beta chain TUB2 0.0087
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0087
6102 Arylamine N-acetyltransferase 2 NAT2 0.0086
124 Histamine H2 receptor HRH2 0.0085
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0085
869 Estrogen receptor beta ESR2 0.0083
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0083
131 Synaptic vesicular amine transporter SLC18A2 0.008
565 Extracellular calcium-sensing receptor CASR 0.008
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0079
173 Toll-like receptor 7 TLR7 0.0079
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0078
295 Carbonic anhydrase 1 CA1 0.0076
614 Progesterone receptor PGR 0.0076
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0074
1256 5-hydroxytryptamine 6 receptor HTR6 0.0074
380 Cytochrome P450 17A1 CYP17A1 0.0073
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0073
4148 Serine/threonine-protein kinase mTOR MTOR 0.0073
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0072
790 DNA polymerase subunit alpha B POLA2 0.0071
592 Carbonic anhydrase 4 CA4 0.0071
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.007
6137 Multidrug resistance-associated protein 6 ABCC6 0.0069
29 Tubulin beta-1 chain TUBB1 0.0069
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0069
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0069
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0067
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0067
373 Transthyretin TTR 0.0066
3932 Glutathione S-transferase A2 GSTA2 0.0066
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0065
756 Sex hormone-binding globulin SHBG 0.0065
26 Vascular endothelial growth factor receptor 3 FLT4 0.0064
563 Thyroid peroxidase TPO 0.0064
407 Vascular endothelial growth factor receptor 2 KDR 0.0064
571 Melatonin receptor type 1A MTNR1A 0.0064
362 Melatonin receptor type 1B MTNR1B 0.0064
251 Alcohol dehydrogenase 1A ADH1A 0.0063
444 Alcohol dehydrogenase 1B ADH1B 0.0063
32 Vascular endothelial growth factor receptor 1 FLT1 0.0061
228 Beta platelet-derived growth factor receptor PDGFRB 0.0061
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0061
284 DNA-directed RNA polymerase beta chain rpoB 0.0061
5773 DNA-directed RNA polymerase beta chain rpoB 0.0061
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0061
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.006
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.006
1024 Solute carrier family 22 member 11 SLC22A11 0.006
6126 Carbonic anhydrase 7 CA7 0.006
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0059
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0059
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0059
6432 Transporter snf 0.0059
814 Ryanodine receptor 1 RYR1 0.0058
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0058
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0058
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0057
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0056
751 Potassium channel subfamily K member 6 KCNK6 0.0056
904 Glutathione S-transferase P GSTP1 0.0055
365 Dihydrofolate reductase DHFR 0.0055
2381 Dihydrofolate reductase DFR1 0.0055
2833 Dihydrofolate reductase Not Available 0.0055
2931 Dihydrofolate reductase folA 0.0055
3544 Dihydrofolate reductase folA 0.0055
3682 Dihydrofolate reductase folA 0.0055
6642 Dihydrofolate reductase folA 0.0055
6756 Dihydrofolate reductase dfrA 0.0055
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0055
6506 Stathmin-4 STMN4 0.0055
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0054
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0053
6138 Multidrug resistance protein 3 ABCB4 0.0053
390 Adenosine A3 receptor ADORA3 0.0053
5998 Toll-like receptor 8 TLR8 0.0053
357 Carbonic anhydrase 2 CA2 0.0053
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0052
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0052
427 Substance-P receptor TACR1 0.0052
712 Tubulin alpha chain TUB1 0.0052
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0052
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0052
3823 Cytokine receptor common gamma chain IL2RG 0.0051
856 Vitamin D3 receptor VDR 0.0051
2112 Toll-like receptor 9 TLR9 0.0051
518 Peroxidase/catalase T katG 0.005
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.005
6766 O-GlcNAcase BT_4395 BT_4395 0.0049
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0049
3404 Exotoxin A eta 0.0049
517 Alcohol dehydrogenase 1C ADH1C 0.0049
1517 Beta-3 adrenergic receptor ADRB3 0.0048
6141 Sodium/bile acid cotransporter SLC10A1 0.0048
1192 Sulfotransferase 1A1 SULT1A1 0.0048
153 Dopamine beta-hydroxylase DBH 0.0047
723 Cytosolic phospholipase A2 PLA2G4A 0.0047
511 5-hydroxytryptamine 1F receptor HTR1F 0.0046
4228 Keratin, type II cytoskeletal 7 KRT7 0.0046
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0046
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0046
4237 50S ribosomal protein L22 rplV 0.0046
2230 Catalase CAT 0.0045
3249 Catalase katA 0.0045
3625 Catalase katA 0.0045
4539 Catalase katA 0.0045
4941 Catalase katB 0.0045
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0045
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0045
1050 Bile salt sulfotransferase SULT2A1 0.0045
70 Type-1 angiotensin II receptor AGTR1 0.0045
724 Interleukin-2 receptor alpha chain IL2RA 0.0045
717 Interleukin-2 receptor subunit beta IL2RB 0.0045
2178 Metabotropic glutamate receptor 5 GRM5 0.0045
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0044
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0044
3937 Fatty-acid amide hydrolase FAAH 0.0044
4116 Dihydropteroate synthetase Not Available 0.0044
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0043
3810 Catechol O-methyltransferase COMT 0.0043
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0043
275 Arachidonate 5-lipoxygenase ALOX5 0.0043
823 Fibroblast growth factor receptor 2 FGFR2 0.0043
473 L-lactate dehydrogenase A chain LDHA 0.0042
1629 Transcription factor AP-1 JUN 0.0042
714 Glutathione reductase, mitochondrial GSR 0.0042
528 5-hydroxytryptamine 1E receptor HTR1E 0.0042
2449 Tubulin alpha-3 chain TUBA1A 0.0041
6043 Putative G-protein coupled receptor 44 GPR44 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
1618 High affinity nerve growth factor receptor NTRK1 0.004
273 Apoptosis regulator Bcl-2 BCL2 0.004
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.004
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.004
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.004
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0039
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0039
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0039
2290 ADP-ribosyl cyclase 2 BST1 0.0039
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
6146 High affinity copper uptake protein 1 SLC31A1 0.0039
319 Opioid receptor, sigma 1 OPRS1 0.0038
6131 Carbonic anhydrase 14 CA14 0.0038
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0038
605 Fumarate reductase flavoprotein subunit frdA 0.0038
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0038
3673 Fumarate reductase flavoprotein subunit fccA 0.0038
4912 Fumarate reductase flavoprotein subunit ifcA 0.0038
6549 Fumarate reductase flavoprotein subunit frdA 0.0038
1483 Membrane copper amine oxidase AOC3 0.0038
7 Nitric oxide synthase, inducible NOS2 0.0038
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0038
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0037
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0037
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0037
4311 tRNA TRDMT1 0.0037
4325 tRNA trmD 0.0037
4328 tRNA trmD 0.0037
908 Glutathione S-transferase theta-1 GSTT1 0.0037
581 Cytochrome P450 2R1 CYP2R1 0.0037
6044 Serum paraoxonase/lactonase 3 PON3 0.0036
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0036
3957 Adenosine deaminase ADA 0.0036
68 Cannabinoid receptor 1 CNR1 0.0036
6122 Carbonic anhydrase 3 CA3 0.0036
543 Penicillin-binding protein 1B mrcB 0.0035
6186 Penicillin-binding protein 1B ponB 0.0035
6822 Penicillin-binding protein 1b pbp1b 0.0035
6844 Penicillin-binding protein 1b pbp1b 0.0035
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0035
185 Vasopressin V1a receptor AVPR1A 0.0035
117 Sterol O-acyltransferase 1 SOAT1 0.0035
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0035
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0035
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0035
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0035
159 Penicillin-binding protein 2B penA 0.0035
6121 Penicillin-binding protein 2B penA 0.0035
939 50S ribosomal protein L3 rplC 0.0035
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0035
322 Vasopressin V2 receptor AVPR2 0.0034
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0034
2499 Tubulin beta-2C chain TUBB2C 0.0034
634 Squalene monooxygenase SQLE 0.0034
7196 Squalene monooxygenase ERG1 0.0034
84 Nuclear receptor 0B1 NR0B1 0.0033
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0033
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0033
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0033
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0032
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0032
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0032
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0032
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0032
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0032
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0032
820 Glycine receptor subunit alpha-2 GLRA2 0.0032
3090 Chitosanase csn 0.0031
4149 Nuclear factor NF-kappa-B p100 subunit NFKB2 0.0031
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
1636 Trace amine-associated receptor 1 TAAR1 0.0031
976 Platelet glycoprotein IX GP9 0.0031
1262 Corticotropin-lipotropin POMC 0.0031
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0031
1374 Natriuretic peptides B NPPB 0.0031
1827 Gap junction alpha-1 protein GJA1 0.0031
65 Matrix metalloproteinase-9 Not Available 0.0031
1908 Vascular cell adhesion protein 1 VCAM1 0.0031
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.003
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.003
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.003
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.003
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.003
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.003
2578 Tubulin beta-3 chain TUBB3 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.003
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.003
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.003
4203 Histamine N-methyltransferase HNMT 0.003
780 Retinoic acid receptor RXR-gamma RXRG 0.003
183 Vascular endothelial growth factor A VEGFA 0.0029
4238 50S ribosomal protein L4 rplD 0.0029
5578 50S ribosomal protein L4 rplD 0.0029
6173 50S ribosomal protein L4 rplD 0.0029
6219 50S ribosomal protein L4 rplD 0.0029
165 FL cytokine receptor FLT3 0.0029
3917 Methylenetetrahydrofolate reductase MTHFR 0.0029
738 Monocarboxylate transporter 1 SLC16A1 0.0029
512 DNA-directed RNA polymerase alpha chain rpoA 0.0029
5772 DNA-directed RNA polymerase alpha chain rpoA 0.0029
2298 Cytochrome P450-cam camC 0.0028
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0028
1253 Interferon gamma IFNG 0.0028
330 Spermidine synthase SRM 0.0028
3038 Spermidine synthase speE 0.0028
239 Coagulation factor X F10 0.0028
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0028
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0028
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0028
1360 Sphingomyelin phosphodiesterase SMPD1 0.0028
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
3856 Fibroblast growth factor receptor 3 FGFR3 0.0027
88 Retinoic acid receptor RXR-beta RXRB 0.0027
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0027
3007 Carbonic anhydrase 12 CA12 0.0027
4205 Carbonic anhydrase 9 CA9 0.0027
3849 Insulin-like growth factor-binding protein 7 IGFBP7 0.0027
2009 Protein NOV homolog NOV 0.0027
3847 Neuroendocrine convertase 2 PCSK2 0.0027
1949 Carboxypeptidase E CPE 0.0027
3850 Synaptotagmin-like protein 4 SYTL4 0.0027
3848 Neuroendocrine convertase 1 PCSK1 0.0027
3846 Retinoblastoma-associated protein RB1 0.0027
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0026
896 Glutathione S-transferase Mu 1 GSTM1 0.0026
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0026
268 Adenosine A2b receptor ADORA2B 0.0026
1648 Elastin ELN 0.0026
3809 Estrogen-related receptor gamma ESRRG 0.0026
6135 Sodium channel subunit beta-4 SCN4B 0.0026
6134 Sodium channel subunit beta-3 SCN3B 0.0026
6132 Sodium channel subunit beta-1 SCN1B 0.0026
6127 Carbonic anhydrase-related protein CA8 0.0026
6133 Sodium channel subunit beta-2 SCN2B 0.0026
6128 Carbonic anhydrase-related protein 10 CA10 0.0026
6129 Carbonic anhydrase-related protein 11 CA11 0.0026
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0026
49 Endothelin B receptor EDNRB 0.0026
4192 DNA topoisomerase 2-beta TOP2B 0.0025
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0025
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0025
1268 Neuropeptide S receptor NPSR1 0.0025
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0025
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0025
1992 Vitamin D-binding protein GC 0.0025
164 Histamine H4 receptor HRH4 0.0025
5880 Thrombopoietin receptor MPL 0.0025
768 FK506-binding protein 1A FKBP1A 0.0025
358 Cystathionine beta-synthase CBS 0.0025
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0025
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0024
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0024
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0024
578 Endothelin-1 receptor EDNRA 0.0024
334 S-adenosylmethionine synthetase isoform type-2 MAT2A 0.0024
291 Nitric-oxide synthase, endothelial NOS3 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
469 Annexin A1 ANXA1 0.0024
6070 Nischarin NISCH 0.0024
233 Potassium channel subfamily K member 2 KCNK2 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0023
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0023
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0023
1630 Integrin beta-2 ITGB2 0.0023
3086 Plasmepsin-2 Not Available 0.0023
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0023
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0023
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0023
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0023
1830 5'-nucleotidase NT5E 0.0023
6085 Fatty acid-binding protein, intestinal FABP2 0.0023
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.0023
6073 Potassium channel subfamily K member 9 KCNK9 0.0023
5787 Angiopoietin-1 receptor TEK 0.0023
6072 Potassium channel subfamily K member 3 KCNK3 0.0023
6163 Copper-transporting ATPase 2 ATP7B 0.0023
6165 Copper-transporting ATPase 1 ATP7A 0.0023
1353 DNA topoisomerase 1 TOP1 0.0023
3552 DNA topoisomerase 1 topA 0.0023
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0023
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0023
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0023
208 DNA-directed RNA polymerase beta' chain rpoC 0.0022
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0022
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0022
113 S-adenosylmethionine decarboxylase proenzyme AMD1 0.0022
6130 Carbonic anhydrase 13 CA13 0.0022
1275 Estrogen sulfotransferase SULT1E1 0.0022
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0022
411 Glycine N-methyltransferase GNMT 0.0022
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0022
2155 Insulin-degrading enzyme IDE 0.0022
298 Renin REN 0.0021
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0021
2091 Endoplasmin HSP90B1 0.0021
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.0021
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0021
2539 Tubulin alpha-1 chain TUBA4A 0.0021
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0021
63 Malate dehydrogenase mdh 0.0021
2329 Malate dehydrogenase mdh 0.0021
3445 Malate dehydrogenase mdh 0.0021
4420 Malate dehydrogenase mdh 0.0021
4438 Malate dehydrogenase mdh 0.0021
5934 Cytochrome P450 26A1 CYP26A1 0.0021
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0021
3601 Dihydropteroate synthase 1 folP1 0.0021
3807 Dihydropteroate synthase 1 folP1 0.0021
3808 Dihydropteroate synthase 2 folP2 0.0021
400 Coagulation factor IX F9 0.0021
5461 Coagulation factor IX F9 0.0021
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.002
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.002
1820 Beta-nerve growth factor NGF 0.002
936 Ephrin type-A receptor 2 EPHA2 0.002
2236 Casein kinase II subunit alpha CSNK2A1 0.0019
633 Penicillin-binding proteins 1A/1B pbpA 0.0019
3913 Glutamic acid decarboxylase GAD65 0.0019
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0019
718 Folate receptor gamma FOLR3 0.0019
299 Folate receptor beta FOLR2 0.0019
804 Mitochondrial folate transporter/carrier SLC25A32 0.0019
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0019
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0019
604 Vitamin K-dependent protein Z PROZ 0.0019
54 Prothrombin F2 0.0018
893 [Citrate [pro-3S]-lyase] ligase citC 0.0018
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
327 Glutathione reductase gor 0.0018
5110 Glutathione reductase GR2 0.0018
4103 Proteasome subunit beta type 2 PSMB2 0.0018
4102 Proteasome subunit beta type 5 PSMB5 0.0018
4101 Proteasome subunit beta type 1 PSMB1 0.0018
683 Potassium transporter GK0582 0.0018
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0018
162 Retinoic acid receptor gamma-1 RARG 0.0018
459 Retinoic acid receptor RXR-alpha RXRA 0.0018
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
2207 Rhodopsin RHO 0.0017
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0017
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0017
422 Vitamin K-dependent protein C PROC 0.0017
1245 Vitamin K-dependent protein S PROS1 0.0017
293 Gamma-glutamyl hydrolase GGH 0.0017
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0017
144 Hemoglobin subunit alpha HBA1 0.0016
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0016
4773 Deoxycytidine kinase DCK 0.0016
735 Alanine aminotransferase 1 GPT 0.0016
3904 Alanine aminotransferase 2 GPT2 0.0016
1243 Cathepsin D CTSD 0.0016
1039 Histone deacetylase 9 HDAC9 0.0016
1852 Microtubule-associated protein 2 MAP2 0.0016
3233 Bile acid receptor NR1H4 0.0015
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0015
2981 Phospholipase A2, membrane associated PLA2G2A 0.0015
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0015
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0015
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0015
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0015
1714 Mitogen-activated protein kinase 3 MAPK3 0.0015
828 Phenylalanine-4-hydroxylase PAH 0.0015
3109 Phenylalanine-4-hydroxylase phhA 0.0015
3844 HLA class II histocompatibility antigen, DQ(6) alpha chain HLA-DQA2 0.0015
1650 Heme carrier protein 1 SLC46A1 0.0015
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0015
719 Retinoic acid receptor responder protein 1 RARRES1 0.0014
770 Retinoic acid-induced protein 3 GPRC5A 0.0014
6824 Tyrosine-protein kinase Lyn LYN 0.0014
1541 Metalloproteinase mmp20 0.0014
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0014
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0014
6167 Organic solute transporter subunit beta OSTB 0.0014
6166 Organic solute transporter subunit alpha OSTA 0.0014
798 Osteocalcin BGLAP 0.0014
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0014
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0014
1341 Histamine H3 receptor HRH3 0.0014
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0014
6859 Protein S100-A4 S100A4 0.0014
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0013
1864 RET proto-oncogene RET 0.0013
5798 Mitogen-activated protein kinase 11 MAPK11 0.0013
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0013
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0013
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0013
244 Angiotensin-converting enzyme ACE 0.0013
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0013
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0013
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0013
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0013
6211 Tubulin epsilon chain TUBE1 0.0013
6212 Tubulin gamma-1 chain TUBG1 0.0013
6210 Tubulin delta chain TUBD1 0.0013
6168 Solute carrier family 22 member 16 SLC22A16 0.0013
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0013
569 Retinal dehydrogenase 2 ALDH1A2 0.0013
267 Plasminogen activator inhibitor 1 SERPINE1 0.0013
369 Coagulation factor VII F7 0.0013
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0013
860 Nicotinamide N-methyltransferase NNMT 0.0013
5626 Nucleoside diphosphate kinase B NME2 0.0013
699 Nicotinic acid receptor 1 GPR109A 0.0013
928 Nicotinic acid receptor 2 GPR109B 0.0013
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0013
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
760 Fibroblast growth factor 1 FGF1 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
85 Growth hormone receptor GHR 0.0012
2107 Microtubule-associated protein 1A MAP1A 0.0012
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
611 Retinal dehydrogenase 1 ALDH1A1 0.0012
1295 Fatty acid synthase FASN 0.0012
6221 Steroid hormone receptor ERR1 ESRRA 0.0012
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0011
1063 Signal transducer and activator of transcription 5B STAT5B 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
3221 Cytochrome c4 cc4 0.0011
24 Thymidylate synthase TMP1 0.0011
359 Thymidylate synthase TYMS 0.0011
2626 Thymidylate synthase thyA 0.0011
2729 Thymidylate synthase thyA 0.0011
5352 Thymidylate synthase THYA 0.0011
707 72 kDa type IV collagenase MMP2 0.0011
2300 Lysozyme E 0.001
3633 Lysozyme R 0.001
5597 Lysozyme 17 0.001
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
76 Nitric-oxide synthase, brain NOS1 0.001
3238 Multidrug resistance protein mexA mexA 0.001
3709 Glycerol uptake facilitator protein glpF 0.001
3116 Bacterioferritin bfr 0.001
4906 Bacterioferritin bfr 0.001
4965 Bacterioferritin bfr 0.001
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.001
3173 Enolase eno 0.001
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.001
3393 TGF-beta receptor type-2 TGFBR2 0.001
1144 Hepatocyte growth factor receptor MET 0.001
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
5294 Nucleoside diphosphate kinase A NME1 0.001
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.001
2216 Fibroblast growth factor receptor 4 FGFR4 0.001
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.001
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.001
5300 Antigen peptide transporter 1 TAP1 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
2268 Cholesterol oxidase choB 0.0009
2822 Cholesterol oxidase choA 0.0009
997 Protein kinase C beta type PRKCB 0.0009
484 Tyrosine-protein kinase ABL2 ABL2 0.0009
229 Retinoic acid receptor beta RARB 0.0009
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0009
730 Retinoic acid receptor alpha RARA 0.0009
1048 Protein S100-A13 S100A13 0.0009
2226 Protein S100-A12 S100A12 0.0009
6048 Troponin C, skeletal muscle TNNC2 0.0009
2852 DNA mismatch repair protein mutL mutL 0.0009
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0009
1770 Phospholipase C PLCL1 0.0009
2841 Phospholipase C plc 0.0009
6149 Solute carrier family 22 member 10 SLC22A10 0.0009
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0009
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0009
2283 Steroid Delta-isomerase ksi 0.0009
2920 Steroid Delta-isomerase ksi 0.0009
3191 Histidinol dehydrogenase hisD 0.0009
1970 Protein kinase C alpha type PRKCA 0.0009
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0009
2132 Protein S100-B S100B 0.0009
2408 Tyrosine-protein kinase SYK SYK 0.0009
740 Argininosuccinate synthase ASS1 0.0009
865 Argininosuccinate synthase ASS1 0.0009
2680 Argininosuccinate synthase argG 0.0009
3194 Argininosuccinate synthase argG 0.0009
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0008
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0008
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0008
3830 Calreticulin CALR 0.0008
6459 Glycodelin PAEP 0.0008
4692 A/G-specific adenine glycosylase mutY 0.0008
1867 Major prion protein PRNP 0.0008
572 Integrin alpha-L ITGAL 0.0008
2232 Interleukin-5 IL5 0.0008
1593 Mucin-2 MUC2 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0008
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0008
6034 Hydroxyindole O-methyltransferase ASMT 0.0008
500 Monocarboxylate transporter 4 SLC16A3 0.0008
6035 Nuclear receptor ROR-beta RORB 0.0008
6036 Eosinophil peroxidase EPX 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
1025 Aquaporin-1 AQP1 0.0008
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0007
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0007
4226 Uridine phosphorylase 2 UPP2 0.0007
461 Glycine receptor subunit alpha-3 GLRA3 0.0007
130 Prostacyclin synthase PTGIS 0.0007
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0007
6103 Arylamine N-acetyltransferase 1 NAT1 0.0007
2802 Endoglucanase G celCCG 0.0007
822 Aldose reductase AKR1B1 0.0007
6316 ADP-ribosylation factor 1 ARF1 0.0007
6228 Nuclear receptor coactivator 1 NCOA1 0.0007
6207 30S ribosomal protein S14 rpsN 0.0007
6209 30S ribosomal protein S19 rpsS 0.0007
6712 30S ribosomal protein S19 rpsS 0.0007
6726 30S ribosomal protein S19 rpsS 0.0007
6241 Nuclear receptor coactivator 2 NCOA2 0.0007
645 Penicillin-binding protein 1A mrcA 0.0007
5805 Penicillin-binding protein 1A ponA 0.0007
6185 Penicillin-binding protein 1A mrcA 0.0007
6799 Penicillin-binding protein 1A pbpA 0.0007
5924 Microtubule-associated protein 4 MAP4 0.0007
5923 Microtubule-associated protein tau MAPT 0.0007
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
765 Indoleamine 2,3-dioxygenase IDO1 0.0007
4225 Uridine phosphorylase 1 UPP1 0.0007
125 DNA polymerase beta POLB 0.0007
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0007
1123 Eosinophil cationic protein RNASE3 0.0007
2599 Tyrosine-protein kinase HCK HCK 0.0007
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0006
413 Amidophosphoribosyltransferase PPAT 0.0006
2515 Amidophosphoribosyltransferase purF 0.0006
3714 Amidophosphoribosyltransferase purF 0.0006
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0006
106 Cannabinoid receptor 2 CNR2 0.0006
6174 50S ribosomal protein L32 rpmF 0.0006
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0006
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0006
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0006
1196 Complement decay-accelerating factor CD55 0.0006
3426 Glutamine synthetase glnA 0.0006
3987 Glutamine synthetase GLUL 0.0006
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0006
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0006
3611 Cytidine deaminase cdd 0.0006
3707 Cytidine deaminase cdd 0.0006
4211 Cytidine deaminase CDA 0.0006
1291 cAMP response element-binding protein CREB1 0.0006
1569 G1/S-specific cyclin-D1 CCND1 0.0006
1525 Heparin-binding growth factor 2 FGF2 0.0006
4210 Toll-like receptor 4 TLR4 0.0005
2808 Chloramphenicol acetyltransferase 3 cat3 0.0005
1760 Aminopeptidase N ANPEP 0.0005
6843 Aminopeptidase N pepN 0.0005
3639 Thymidine phosphorylase deoA 0.0005
3936 Thymidine phosphorylase TYMP 0.0005
6151 Monocarboxylate transporter 10 SLC16A10 0.0005
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0005
2417 Chloramphenicol acetyltransferase cat 0.0005
3278 Chloramphenicol acetyltransferase cat 0.0005
2810 Dr hemagglutinin structural subunit draA 0.0005
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0005
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0005
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0004
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0004
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0004
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0004
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0004
4925 Cytochrome c-type protein SHP shp 0.0004
4954 Soluble cytochrome b558 Not Available 0.0004
4916 Cyanoglobin glbN 0.0004
4994 Hemoglobin-like protein HbO glbO 0.0004
4915 Cytochrome c-550 psbV 0.0004
4959 Cytochrome c-550 psbV 0.0004
5216 Cytochrome c-550 psbV 0.0004
4943 Cytochrome c6 petJ 0.0004
4984 Neuroglobin NGB 0.0004
4947 Bacterial hemoglobin vhb 0.0004
4975 Cytochrome c-556 RPA3973 0.0004
4934 Cytochrome c-551 nirM 0.0004
5218 Cytochrome c-551 nirM 0.0004
4936 Cytochrome c2 iso-2 Not Available 0.0004
4905 Cytochrome c2 Not Available 0.0004
4939 Cytochrome c2 cycA 0.0004
4964 Cytochrome c2 cycA 0.0004
4979 Cytochrome c2 cycA 0.0004
6673 Cytochrome c2 cycA 0.0004
4910 Cytoglobin CYGB 0.0004
4981 Iron-starvation protein PigA pigA 0.0004
4909 CooA protein cooA 0.0004
4907 Cytochrome c-L moxG 0.0004
6865 Cytochrome c-L moxG 0.0004
4998 Hemoglobin-like protein yjbI yjbI 0.0004
5000 HemO hemO 0.0004
4942 Diheme cytochrome c napB napB 0.0004
4935 Cytochrome c-554 cycA1 0.0004
644 Heme oxygenase 2 HMOX2 0.0004
4982 Heme oxygenase 2 pbsA2 0.0004
4972 P450cin cinA 0.0004
4904 Cytochrome c family protein GSU1996 0.0004
4971 Nonaheme cytochrome c hmcA 0.0004
4961 Hemophore HasA hasA 0.0004
4976 Apocytochrome f petA 0.0004
6407 Apocytochrome f petA 0.0004
4931 Cytochrome P450 167A1 CYP167A1 0.0004
4960 Putative cytochrome P450-family protein SCO7417 0.0004
4764 Cytochrome P450 165C4 CYP165C4 0.0004
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0004
4903 Methyl-accepting chemotaxis protein Tar4 0.0004
4926 Heme-based aerotactic transducer hemAT hemAT 0.0004
4999 Cytochrome P450 165B3 CYP165B3 0.0004
4993 Hydroxylamine oxidoreductase hao1 0.0004
4989 Cytochrome c551 peroxidase ccp 0.0004
5222 Cytochrome c551 peroxidase ccpA 0.0004
4937 Cytochrome oxidase subunit II rcoxA 0.0004
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0004
4922 Cytochrome c, putative SO_4144 0.0004
4952 Catalase/peroxidase katA 0.0004
3093 Catalase HPII katE 0.0004
4217 Telomerase reverse transcriptase TERT 0.0004
1176 Mitogen-activated protein kinase 1 MAPK1 0.0004
594 Thyroxine-binding globulin SERPINA7 0.0004
758 Thyroid hormone receptor alpha THRA 0.0003
2240 Cell division protein kinase 2 CDK2 0.0003
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0003
199 Monocarboxylate transporter 8 SLC16A2 0.0003
2320 Thymidine kinase, cytosolic TK1 0.0003
4920 Peroxidase/catalase katG 0.0003
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0003
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0003
4948 Cytochrome c-553 Not Available 0.0003
4923 Cytochrome c3 DvMF_2499 0.0003
4945 Cytochrome c3 Not Available 0.0003
4949 Cytochrome c3 DVU_3171 0.0003
4968 Cytochrome c3 cytc3 0.0003
4997 Cytochrome c3 SO_2727 0.0003
5219 Cytochrome c3 cyd 0.0003
4902 Nine-heme cytochrome c Ddes_2038 0.0003
2119 Cytochrome b5 CYB5A 0.0003
4990 PpcA ppcA 0.0003
3189 High-molecular-weight cytochrome c hmcA 0.0003
3375 Acidic cytochrome c3 Not Available 0.0003
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0003
4988 Sulfite oxidase, mitochondrial SUOX 0.0003
2915 Sensor protein fixL fixL 0.0003
4944 Sensor protein fixL fixL 0.0003
4385 Cytochrome c' Not Available 0.0003
4967 Cytochrome c' cycA 0.0003
5038 Cytochrome c' Not Available 0.0003
5223 Cytochrome c' cycP 0.0003
4813 Heme oxygenase hmuO 0.0003
5769 Heme oxygenase Not Available 0.0003
3570 Cytochrome P450 152A1 cypC 0.0003
4037 Hypothetical protein GPX1 0.0003
4297 Hypothetical protein SP_1951 0.0003
4521 Hypothetical protein BC_2969 0.0003
4540 Hypothetical protein TM_1070 0.0003
4555 Hypothetical protein MT1739 0.0003
4569 Hypothetical protein mshD 0.0003
4578 Hypothetical protein PA3270 0.0003
4747 Hypothetical protein PA3967 0.0003
5177 Hypothetical protein TM_0096 0.0003
5194 Hypothetical protein PA1204 0.0003
5240 Hypothetical protein Rv2991 0.0003
5370 Hypothetical protein TM_1158 0.0003
5710 Hypothetical protein Tb927.5.1360 0.0003
4289 Cytochrome P450 TT_P0059 0.0003
6262 Cytochrome P450 staP 0.0003
4992 Cytochrome c peroxidase Not Available 0.0003
346 Thyroid hormone receptor beta-1 THRB 0.0003
6218 Pannexin-1 PANX1 0.0003
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0003
3411 Cytochrome P450 121 cyp121 0.0003
3670 Soluble cytochrome b562 precursor cybC 0.0003
3291 Cytochrome c-552 cycA 0.0003
4927 Cytochrome c-552 nrfA 0.0003
4938 Cytochrome c-552 cycA 0.0003
4953 Cytochrome c-552 nrfA 0.0003
5217 Cytochrome c-552 cycM 0.0003
2617 Nitric oxide synthase oxygenase nos 0.0003
2701 Nitric oxide synthase oxygenase nos 0.0003
4386 Hemoglobin-like protein HbN glbN 0.0003
3102 Flavohemoprotein hmp 0.0003
4969 Flavohemoprotein hmp 0.0003
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0002
3127 Nitrite reductase nirS 0.0002
3284 Nitrite reductase nirS 0.0002
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0002
2972 6-deoxyerythronolide B hydroxylase eryF 0.0002
4608 Putative cytochrome P450 SCO1207 0.0002
4963 Putative cytochrome P450 SCO2884 0.0002
6254 Putative cytochrome P450 SCO6998 0.0002
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0002
1507 Cytochrome c CYCS 0.0002
693 Hemoglobin subunit beta HBB 0.0002
6268 Hydroxyacid oxidase 1 HAO1 0.0002
810 Heme oxygenase 1 HMOX1 0.0002
3391 Heme oxygenase 1 pbsA1 0.0002
489 Monocarboxylate transporter 2 SLC16A7 0.0002
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